-- dump date   	20140618_205457
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1118963000001	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1118963000002	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1118963000003	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1118963000004	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1118963000005	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1118963000006	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1118963000007	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1118963000008	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1118963000009	catalytic loop [active]
1118963000010	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1118963000011	iron binding site [ion binding]; other site
1118963000012	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1118963000013	FAD binding domain; Region: FAD_binding_4; cl19922
1118963000014	xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971
1118963000015	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1118963000016	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1118963000017	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1118963000018	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1118963000019	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1118963000020	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963000021	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963000022	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963000023	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963000024	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1118963000025	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963000026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963000027	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963000028	putative substrate translocation pore; other site
1118963000029	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1118963000030	Ligand binding site; other site
1118963000031	metal-binding site
1118963000032	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1118963000033	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1118963000034	FeS/SAM binding site; other site
1118963000035	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1118963000036	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1118963000037	MoaE homodimer interface [polypeptide binding]; other site
1118963000038	MoaD interaction [polypeptide binding]; other site
1118963000039	active site residues [active]
1118963000040	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1118963000041	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1118963000042	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1118963000043	adenylate kinase; Reviewed; Region: adk; PRK00279
1118963000044	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1118963000045	AMP-binding site [chemical binding]; other site
1118963000046	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1118963000047	Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327
1118963000048	PaaX-like protein; Region: PaaX; pfam07848
1118963000049	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1118963000050	Putative transmembrane protein precursor; Region: Tmpp129; pfam10272
1118963000051	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1118963000052	homotrimer interaction site [polypeptide binding]; other site
1118963000053	putative active site [active]
1118963000054	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1118963000055	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1118963000056	Cupin domain; Region: Cupin_2; cl17218
1118963000057	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1118963000058	acyl-CoA thioesterase II; Region: tesB; TIGR00189
1118963000059	active site
1118963000060	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1118963000061	catalytic triad [active]
1118963000062	dimer interface [polypeptide binding]; other site
1118963000063	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1118963000064	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1118963000065	acyl-activating enzyme (AAE) consensus motif; other site
1118963000066	AMP binding site [chemical binding]; other site
1118963000067	active site
1118963000068	CoA binding site [chemical binding]; other site
1118963000069	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
1118963000070	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963000071	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1118963000072	active site
1118963000073	FMN binding site [chemical binding]; other site
1118963000074	substrate binding site [chemical binding]; other site
1118963000075	homotetramer interface [polypeptide binding]; other site
1118963000076	catalytic residue [active]
1118963000077	PaaX-like protein; Region: PaaX; pfam07848
1118963000078	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
1118963000079	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1118963000080	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1118963000081	active site
1118963000082	TIR domain; Region: TIR_2; pfam13676
1118963000083	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1118963000084	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
1118963000085	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1118963000086	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1118963000087	generic binding surface II; other site
1118963000088	generic binding surface I; other site
1118963000089	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1118963000090	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
1118963000091	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963000092	active site
1118963000093	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1118963000094	Catalytic site [active]
1118963000095	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
1118963000096	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1118963000097	active site
1118963000098	DNA binding site [nucleotide binding]
1118963000099	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1118963000100	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1118963000101	catalytic residues [active]
1118963000102	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963000103	Walker A motif; other site
1118963000104	ATP binding site [chemical binding]; other site
1118963000105	Walker B motif; other site
1118963000106	arginine finger; other site
1118963000107	HprK-related kinase A; Region: HprK_rel_A; TIGR04352
1118963000108	Zeta toxin; Region: Zeta_toxin; pfam06414
1118963000109	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1118963000110	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1118963000111	Peptidase family M23; Region: Peptidase_M23; pfam01551
1118963000112	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1118963000113	NlpC/P60 family; Region: NLPC_P60; cl17555
1118963000114	Arsenite-resistance protein 2; Region: ARS2; pfam04959
1118963000115	AAA-like domain; Region: AAA_10; pfam12846
1118963000116	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1118963000117	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1118963000118	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1118963000119	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
1118963000120	MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685
1118963000121	TIGR02687 family protein; Region: TIGR02687
1118963000122	PglZ domain; Region: PglZ; pfam08665
1118963000123	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
1118963000124	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
1118963000125	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
1118963000126	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1118963000127	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1118963000128	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1118963000129	P-loop; other site
1118963000130	Magnesium ion binding site [ion binding]; other site
1118963000131	Predicted membrane protein [Function unknown]; Region: COG5373
1118963000132	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1118963000133	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1118963000134	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1118963000135	Walker A motif; other site
1118963000136	ATP binding site [chemical binding]; other site
1118963000137	Walker B motif; other site
1118963000138	Type II secretion system (T2SS), protein F; Region: T2SF; cl19503
1118963000139	TadE-like protein; Region: TadE; pfam07811
1118963000140	TadE-like protein; Region: TadE; pfam07811
1118963000141	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
1118963000142	Lysosome-associated membrane glycoprotein (Lamp); Region: Lamp; pfam01299
1118963000143	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
1118963000144	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1118963000145	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1118963000146	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
1118963000147	CHC2 zinc finger; Region: zf-CHC2; cl17510
1118963000148	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1118963000149	active site
1118963000150	metal binding site [ion binding]; metal-binding site
1118963000151	interdomain interaction site; other site
1118963000152	Domain of unknown function (DUF927); Region: DUF927; cl12098
1118963000153	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963000154	non-specific DNA binding site [nucleotide binding]; other site
1118963000155	sequence-specific DNA binding site [nucleotide binding]; other site
1118963000156	salt bridge; other site
1118963000157	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
1118963000158	MerR family regulatory protein; Region: MerR; pfam00376
1118963000159	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1118963000160	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963000161	Walker A motif; other site
1118963000162	ATP binding site [chemical binding]; other site
1118963000163	Walker B motif; other site
1118963000164	arginine finger; other site
1118963000165	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1118963000166	DnaA box-binding interface [nucleotide binding]; other site
1118963000167	DNA polymerase III subunit beta; Validated; Region: PRK07761
1118963000168	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1118963000169	putative DNA binding surface [nucleotide binding]; other site
1118963000170	dimer interface [polypeptide binding]; other site
1118963000171	beta-clamp/clamp loader binding surface; other site
1118963000172	beta-clamp/translesion DNA polymerase binding surface; other site
1118963000173	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1118963000174	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1118963000175	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1118963000176	recombination protein F; Reviewed; Region: recF; PRK00064
1118963000177	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963000178	Walker A/P-loop; other site
1118963000179	ATP binding site [chemical binding]; other site
1118963000180	Q-loop/lid; other site
1118963000181	ABC transporter signature motif; other site
1118963000182	Walker B; other site
1118963000183	D-loop; other site
1118963000184	H-loop/switch region; other site
1118963000185	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1118963000186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963000187	ATP binding site [chemical binding]; other site
1118963000188	Mg2+ binding site [ion binding]; other site
1118963000189	G-X-G motif; other site
1118963000190	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1118963000191	anchoring element; other site
1118963000192	dimer interface [polypeptide binding]; other site
1118963000193	ATP binding site [chemical binding]; other site
1118963000194	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1118963000195	active site
1118963000196	putative metal-binding site [ion binding]; other site
1118963000197	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1118963000198	DNA gyrase subunit A; Validated; Region: PRK05560
1118963000199	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1118963000200	CAP-like domain; other site
1118963000201	active site
1118963000202	primary dimer interface [polypeptide binding]; other site
1118963000203	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1118963000204	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1118963000205	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1118963000206	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1118963000207	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1118963000208	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1118963000209	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
1118963000210	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1118963000211	EamA-like transporter family; Region: EamA; pfam00892
1118963000212	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1118963000213	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1118963000214	active site
1118963000215	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1118963000216	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
1118963000217	active site
1118963000218	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cd00021
1118963000219	Zn2+ binding site [ion binding]; other site
1118963000220	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1118963000221	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1118963000222	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1118963000223	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
1118963000224	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1118963000225	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1118963000226	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1118963000227	DNA binding site [nucleotide binding]
1118963000228	active site
1118963000229	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1118963000230	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963000231	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1118963000232	DNA binding residues [nucleotide binding]
1118963000233	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1118963000234	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1118963000235	DNA binding site [nucleotide binding]
1118963000236	active site
1118963000237	Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781
1118963000238	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
1118963000239	active site
1118963000240	catalytic site [active]
1118963000241	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1118963000242	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1118963000243	glutamine binding [chemical binding]; other site
1118963000244	catalytic triad [active]
1118963000245	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1118963000246	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1118963000247	active site
1118963000248	ATP binding site [chemical binding]; other site
1118963000249	substrate binding site [chemical binding]; other site
1118963000250	activation loop (A-loop); other site
1118963000251	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1118963000252	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1118963000253	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1118963000254	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1118963000255	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1118963000256	active site
1118963000257	ATP binding site [chemical binding]; other site
1118963000258	substrate binding site [chemical binding]; other site
1118963000259	activation loop (A-loop); other site
1118963000260	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1118963000261	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1118963000262	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1118963000263	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1118963000264	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1118963000265	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1118963000266	active site
1118963000267	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1118963000268	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1118963000269	phosphopeptide binding site; other site
1118963000270	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
1118963000271	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1118963000272	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1118963000273	phosphopeptide binding site; other site
1118963000274	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1118963000275	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963000276	DNA-binding site [nucleotide binding]; DNA binding site
1118963000277	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1118963000278	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1118963000279	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1118963000280	active site pocket [active]
1118963000281	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
1118963000282	mannose binding site [chemical binding]; other site
1118963000283	dimerization interface [polypeptide binding]; other site
1118963000284	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1118963000285	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963000286	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1118963000287	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1118963000288	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
1118963000289	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963000290	Ligand Binding Site [chemical binding]; other site
1118963000291	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963000292	Ligand Binding Site [chemical binding]; other site
1118963000293	Amino acid permease; Region: AA_permease_2; pfam13520
1118963000294	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1118963000295	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1118963000296	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
1118963000297	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963000298	DNA-binding site [nucleotide binding]; DNA binding site
1118963000299	FCD domain; Region: FCD; pfam07729
1118963000300	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1118963000301	putative active site [active]
1118963000302	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963000303	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963000304	putative substrate translocation pore; other site
1118963000305	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1118963000306	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1118963000307	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1118963000308	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1118963000309	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1118963000310	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1118963000311	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1118963000312	carboxyltransferase (CT) interaction site; other site
1118963000313	biotinylation site [posttranslational modification]; other site
1118963000314	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
1118963000315	FAD binding domain; Region: FAD_binding_4; pfam01565
1118963000316	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1118963000317	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963000318	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963000319	DNA binding site [nucleotide binding]
1118963000320	domain linker motif; other site
1118963000321	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963000322	dimerization interface [polypeptide binding]; other site
1118963000323	ligand binding site [chemical binding]; other site
1118963000324	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1118963000325	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1118963000326	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1118963000327	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1118963000328	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1118963000329	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1118963000330	synthetase active site [active]
1118963000331	NTP binding site [chemical binding]; other site
1118963000332	metal binding site [ion binding]; metal-binding site
1118963000333	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963000334	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963000335	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1118963000336	putative substrate binding site [chemical binding]; other site
1118963000337	putative ATP binding site [chemical binding]; other site
1118963000338	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1118963000339	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1118963000340	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1118963000341	putative dimer interface [polypeptide binding]; other site
1118963000342	N-terminal domain interface [polypeptide binding]; other site
1118963000343	putative substrate binding pocket (H-site) [chemical binding]; other site
1118963000344	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963000345	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1118963000346	active site
1118963000347	motif I; other site
1118963000348	motif II; other site
1118963000349	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1118963000350	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1118963000351	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963000352	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963000353	NAD(P) binding site [chemical binding]; other site
1118963000354	active site
1118963000355	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
1118963000356	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1118963000357	putative active site [active]
1118963000358	catalytic site [active]
1118963000359	putative metal binding site [ion binding]; other site
1118963000360	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1118963000361	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1118963000362	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1118963000363	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
1118963000364	dimerization interface [polypeptide binding]; other site
1118963000365	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1118963000366	NAD binding site [chemical binding]; other site
1118963000367	ligand binding site [chemical binding]; other site
1118963000368	catalytic site [active]
1118963000369	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1118963000370	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
1118963000371	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
1118963000372	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1118963000373	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963000374	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963000375	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963000376	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963000377	putative substrate translocation pore; other site
1118963000378	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963000379	putative DNA binding site [nucleotide binding]; other site
1118963000380	putative Zn2+ binding site [ion binding]; other site
1118963000381	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1118963000382	Tachylectin; Region: Tachylectin; pfam14517
1118963000383	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963000384	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963000385	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963000386	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1118963000387	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1118963000388	proposed catalytic triad [active]
1118963000389	conserved cys residue [active]
1118963000390	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
1118963000391	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963000392	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963000393	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963000394	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963000395	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963000396	DNA binding site [nucleotide binding]
1118963000397	domain linker motif; other site
1118963000398	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
1118963000399	putative dimerization interface [polypeptide binding]; other site
1118963000400	putative ligand binding site [chemical binding]; other site
1118963000401	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1118963000402	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
1118963000403	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963000404	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963000405	dimer interface [polypeptide binding]; other site
1118963000406	conserved gate region; other site
1118963000407	putative PBP binding loops; other site
1118963000408	ABC-ATPase subunit interface; other site
1118963000409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963000410	dimer interface [polypeptide binding]; other site
1118963000411	conserved gate region; other site
1118963000412	ABC-ATPase subunit interface; other site
1118963000413	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963000414	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963000415	CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans.  CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412
1118963000416	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1118963000417	active site
1118963000418	S-layer homology domain; Region: SLH; pfam00395
1118963000419	S-layer homology domain; Region: SLH; pfam00395
1118963000420	Sulfate transporter family; Region: Sulfate_transp; cl19250
1118963000421	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
1118963000422	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1118963000423	OpgC protein; Region: OpgC_C; pfam10129
1118963000424	malonic semialdehyde reductase; Provisional; Region: PRK05365
1118963000425	FMN binding site [chemical binding]; other site
1118963000426	dimer interface [polypeptide binding]; other site
1118963000427	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1118963000428	phosphoglucomutase; Validated; Region: PRK07564
1118963000429	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1118963000430	active site
1118963000431	substrate binding site [chemical binding]; other site
1118963000432	metal binding site [ion binding]; metal-binding site
1118963000433	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1118963000434	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963000435	NAD(P) binding site [chemical binding]; other site
1118963000436	active site
1118963000437	Junctional protein associated with coronary artery disease; Region: JCAD; pfam15351
1118963000438	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
1118963000439	POT family; Region: PTR2; cl17359
1118963000440	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1118963000441	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963000442	putative substrate translocation pore; other site
1118963000443	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1118963000444	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
1118963000445	active site pocket [active]
1118963000446	oxyanion hole [active]
1118963000447	catalytic triad [active]
1118963000448	active site nucleophile [active]
1118963000449	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1118963000450	active site residue [active]
1118963000451	prephenate dehydratase; Provisional; Region: PRK11898
1118963000452	Prephenate dehydratase; Region: PDT; pfam00800
1118963000453	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1118963000454	putative L-Phe binding site [chemical binding]; other site
1118963000455	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1118963000456	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1118963000457	seryl-tRNA synthetase; Provisional; Region: PRK05431
1118963000458	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1118963000459	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1118963000460	dimer interface [polypeptide binding]; other site
1118963000461	active site
1118963000462	motif 1; other site
1118963000463	motif 2; other site
1118963000464	motif 3; other site
1118963000465	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1118963000466	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1118963000467	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963000468	active site
1118963000469	motif I; other site
1118963000470	motif II; other site
1118963000471	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1118963000472	Helix-turn-helix domain; Region: HTH_18; pfam12833
1118963000473	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
1118963000474	GAF domain; Region: GAF; cl17456
1118963000475	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1118963000476	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
1118963000477	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963000478	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1118963000479	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
1118963000480	DNA binding residues [nucleotide binding]
1118963000481	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1118963000482	putative active site [active]
1118963000483	hypothetical protein; Validated; Region: PRK06769
1118963000484	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963000485	active site
1118963000486	motif I; other site
1118963000487	motif II; other site
1118963000488	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1118963000489	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1118963000490	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1118963000491	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1118963000492	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1118963000493	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1118963000494	putative ADP-binding pocket [chemical binding]; other site
1118963000495	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1118963000496	dimer interface [polypeptide binding]; other site
1118963000497	active site
1118963000498	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
1118963000499	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1118963000500	substrate binding site [chemical binding]; other site
1118963000501	ATP binding site [chemical binding]; other site
1118963000502	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1118963000503	active site
1118963000504	HIGH motif; other site
1118963000505	nucleotide binding site [chemical binding]; other site
1118963000506	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1118963000507	classical (c) SDRs; Region: SDR_c; cd05233
1118963000508	NAD(P) binding site [chemical binding]; other site
1118963000509	active site
1118963000510	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1118963000511	putative active site [active]
1118963000512	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
1118963000513	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1118963000514	substrate binding site [chemical binding]; other site
1118963000515	ATP binding site [chemical binding]; other site
1118963000516	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1118963000517	active site
1118963000518	nucleotide binding site [chemical binding]; other site
1118963000519	HIGH motif; other site
1118963000520	KMSKS motif; other site
1118963000521	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963000522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963000523	NAD(P) binding site [chemical binding]; other site
1118963000524	active site
1118963000525	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1118963000526	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1118963000527	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
1118963000528	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1118963000529	dimer interface [polypeptide binding]; other site
1118963000530	substrate binding site [chemical binding]; other site
1118963000531	metal binding sites [ion binding]; metal-binding site
1118963000532	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
1118963000533	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1118963000534	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
1118963000535	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1118963000536	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1118963000537	Ligand Binding Site [chemical binding]; other site
1118963000538	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1118963000539	active site
1118963000540	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1118963000541	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1118963000542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963000543	Walker A motif; other site
1118963000544	ATP binding site [chemical binding]; other site
1118963000545	Walker B motif; other site
1118963000546	arginine finger; other site
1118963000547	Peptidase family M41; Region: Peptidase_M41; pfam01434
1118963000548	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1118963000549	active site
1118963000550	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
1118963000551	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1118963000552	substrate binding pocket [chemical binding]; other site
1118963000553	dimer interface [polypeptide binding]; other site
1118963000554	inhibitor binding site; inhibition site
1118963000555	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1118963000556	homooctamer interface [polypeptide binding]; other site
1118963000557	active site
1118963000558	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1118963000559	catalytic center binding site [active]
1118963000560	ATP binding site [chemical binding]; other site
1118963000561	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
1118963000562	Bacterial PH domain; Region: bPH_2; cl01348
1118963000563	Predicted membrane protein [Function unknown]; Region: COG3428
1118963000564	Bacterial PH domain; Region: bPH_2; pfam03703
1118963000565	Bacterial PH domain; Region: bPH_2; pfam03703
1118963000566	Bacterial PH domain; Region: bPH_2; pfam03703
1118963000567	Rossmann-like domain; Region: Rossmann-like; pfam10727
1118963000568	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1118963000569	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1118963000570	active site
1118963000571	ATP-binding site [chemical binding]; other site
1118963000572	pantoate-binding site; other site
1118963000573	HXXH motif; other site
1118963000574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963000575	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963000576	putative substrate translocation pore; other site
1118963000577	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066
1118963000578	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963000579	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
1118963000580	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1118963000581	dimerization interface [polypeptide binding]; other site
1118963000582	Sulfatase; Region: Sulfatase; cl19157
1118963000583	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1118963000584	EamA-like transporter family; Region: EamA; pfam00892
1118963000585	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963000586	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963000587	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963000588	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963000589	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963000590	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963000591	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1118963000592	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1118963000593	dimer interface [polypeptide binding]; other site
1118963000594	putative anticodon binding site; other site
1118963000595	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1118963000596	motif 1; other site
1118963000597	dimer interface [polypeptide binding]; other site
1118963000598	active site
1118963000599	motif 2; other site
1118963000600	motif 3; other site
1118963000601	Lsr2; Region: Lsr2; pfam11774
1118963000602	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1118963000603	Clp amino terminal domain; Region: Clp_N; pfam02861
1118963000604	Clp amino terminal domain; Region: Clp_N; pfam02861
1118963000605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963000606	Walker A motif; other site
1118963000607	ATP binding site [chemical binding]; other site
1118963000608	Walker B motif; other site
1118963000609	arginine finger; other site
1118963000610	UvrB/uvrC motif; Region: UVR; pfam02151
1118963000611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963000612	Walker A motif; other site
1118963000613	ATP binding site [chemical binding]; other site
1118963000614	Walker B motif; other site
1118963000615	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1118963000616	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1118963000617	homodimer interface [polypeptide binding]; other site
1118963000618	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1118963000619	active site
1118963000620	TDP-binding site; other site
1118963000621	acceptor substrate-binding pocket; other site
1118963000622	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1118963000623	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1118963000624	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963000625	Coenzyme A binding pocket [chemical binding]; other site
1118963000626	FAD binding domain; Region: FAD_binding_4; pfam01565
1118963000627	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1118963000628	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1118963000629	DAK2 domain; Region: Dak2; cl03685
1118963000630	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1118963000631	active site
1118963000632	active pocket/dimerization site; other site
1118963000633	phosphorylation site [posttranslational modification]
1118963000634	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1118963000635	dimerization domain swap beta strand [polypeptide binding]; other site
1118963000636	regulatory protein interface [polypeptide binding]; other site
1118963000637	active site
1118963000638	regulatory phosphorylation site [posttranslational modification]; other site
1118963000639	CsbD-like; Region: CsbD; pfam05532
1118963000640	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
1118963000641	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1118963000642	active site
1118963000643	metal binding site [ion binding]; metal-binding site
1118963000644	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1118963000645	putative dimer interface [polypeptide binding]; other site
1118963000646	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963000647	Helix-turn-helix domain; Region: HTH_18; pfam12833
1118963000648	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1118963000649	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1118963000650	minor groove reading motif; other site
1118963000651	helix-hairpin-helix signature motif; other site
1118963000652	substrate binding pocket [chemical binding]; other site
1118963000653	active site
1118963000654	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1118963000655	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
1118963000656	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1118963000657	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1118963000658	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1118963000659	allophanate hydrolase; Provisional; Region: PRK08186
1118963000660	urea carboxylase; Region: urea_carbox; TIGR02712
1118963000661	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1118963000662	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1118963000663	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1118963000664	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1118963000665	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1118963000666	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1118963000667	carboxyltransferase (CT) interaction site; other site
1118963000668	biotinylation site [posttranslational modification]; other site
1118963000669	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1118963000670	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
1118963000671	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
1118963000672	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963000673	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963000674	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963000675	DNA repair protein RadA; Provisional; Region: PRK11823
1118963000676	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1118963000677	Walker A motif; other site
1118963000678	ATP binding site [chemical binding]; other site
1118963000679	Walker B motif; other site
1118963000680	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1118963000681	Predicted membrane protein [Function unknown]; Region: COG4129
1118963000682	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1118963000683	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1118963000684	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1118963000685	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1118963000686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963000687	dimer interface [polypeptide binding]; other site
1118963000688	conserved gate region; other site
1118963000689	putative PBP binding loops; other site
1118963000690	ABC-ATPase subunit interface; other site
1118963000691	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1118963000692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963000693	dimer interface [polypeptide binding]; other site
1118963000694	conserved gate region; other site
1118963000695	putative PBP binding loops; other site
1118963000696	ABC-ATPase subunit interface; other site
1118963000697	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
1118963000698	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1118963000699	Walker A/P-loop; other site
1118963000700	ATP binding site [chemical binding]; other site
1118963000701	Q-loop/lid; other site
1118963000702	ABC transporter signature motif; other site
1118963000703	Walker B; other site
1118963000704	D-loop; other site
1118963000705	H-loop/switch region; other site
1118963000706	Phosphate transporter family; Region: PHO4; pfam01384
1118963000707	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1118963000708	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1118963000709	Sugar-binding cellulase-like; Region: Cellulase-like; cl19200
1118963000710	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1118963000711	GAF domain; Region: GAF_2; pfam13185
1118963000712	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1118963000713	GAF domain; Region: GAF_2; pfam13185
1118963000714	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1118963000715	GAF domain; Region: GAF; pfam01590
1118963000716	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1118963000717	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963000718	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963000719	DNA binding site [nucleotide binding]
1118963000720	domain linker motif; other site
1118963000721	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963000722	dimerization interface [polypeptide binding]; other site
1118963000723	ligand binding site [chemical binding]; other site
1118963000724	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1118963000725	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
1118963000726	dimer interface [polypeptide binding]; other site
1118963000727	active site
1118963000728	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1118963000729	substrate binding site [chemical binding]; other site
1118963000730	catalytic residue [active]
1118963000731	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
1118963000732	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1118963000733	alpha-gamma subunit interface [polypeptide binding]; other site
1118963000734	beta-gamma subunit interface [polypeptide binding]; other site
1118963000735	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1118963000736	gamma-beta subunit interface [polypeptide binding]; other site
1118963000737	alpha-beta subunit interface [polypeptide binding]; other site
1118963000738	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1118963000739	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1118963000740	subunit interactions [polypeptide binding]; other site
1118963000741	active site
1118963000742	flap region; other site
1118963000743	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1118963000744	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1118963000745	dimer interface [polypeptide binding]; other site
1118963000746	catalytic residues [active]
1118963000747	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1118963000748	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1118963000749	UreD urease accessory protein; Region: UreD; cl00530
1118963000750	High-affinity nickel-transport protein; Region: NicO; cl00964
1118963000751	Beta-lactamase; Region: Beta-lactamase; pfam00144
1118963000752	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1118963000753	Catalytic site [active]
1118963000754	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1118963000755	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1118963000756	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963000757	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1118963000758	DNA binding residues [nucleotide binding]
1118963000759	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
1118963000760	Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
1118963000761	active site
1118963000762	catalytic site [active]
1118963000763	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
1118963000764	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
1118963000765	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1118963000766	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963000767	active site
1118963000768	catalytic tetrad [active]
1118963000769	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963000770	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963000771	NAD(P) binding site [chemical binding]; other site
1118963000772	active site
1118963000773	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963000774	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963000775	active site
1118963000776	catalytic tetrad [active]
1118963000777	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963000778	active site
1118963000779	catalytic tetrad [active]
1118963000780	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963000781	salt bridge; other site
1118963000782	non-specific DNA binding site [nucleotide binding]; other site
1118963000783	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1118963000784	sequence-specific DNA binding site [nucleotide binding]; other site
1118963000785	Dodecin; Region: Dodecin; pfam07311
1118963000786	oxidoreductase; Provisional; Region: PRK12743
1118963000787	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963000788	NAD(P) binding site [chemical binding]; other site
1118963000789	active site
1118963000790	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963000791	Ligand Binding Site [chemical binding]; other site
1118963000792	Pectate lyase; Region: Pec_lyase_C; cl01593
1118963000793	Right handed beta helix region; Region: Beta_helix; pfam13229
1118963000794	Pectinesterase; Region: Pectinesterase; cl01911
1118963000795	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1118963000796	Amb_all domain; Region: Amb_all; smart00656
1118963000797	Pectinesterase; Region: Pectinesterase; cl01911
1118963000798	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963000799	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963000800	dimer interface [polypeptide binding]; other site
1118963000801	conserved gate region; other site
1118963000802	putative PBP binding loops; other site
1118963000803	ABC-ATPase subunit interface; other site
1118963000804	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963000805	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963000806	dimer interface [polypeptide binding]; other site
1118963000807	putative PBP binding loops; other site
1118963000808	ABC-ATPase subunit interface; other site
1118963000809	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963000810	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963000811	Methane oxygenase PmoA; Region: PmoA; pfam14100
1118963000812	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
1118963000813	active site
1118963000814	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963000815	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963000816	DNA binding site [nucleotide binding]
1118963000817	Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296
1118963000818	putative dimerization interface [polypeptide binding]; other site
1118963000819	putative ligand binding site [chemical binding]; other site
1118963000820	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1118963000821	dimer interface [polypeptide binding]; other site
1118963000822	PYR/PP interface [polypeptide binding]; other site
1118963000823	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1118963000824	TPP binding site [chemical binding]; other site
1118963000825	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1118963000826	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1118963000827	TPP-binding site [chemical binding]; other site
1118963000828	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1118963000829	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1118963000830	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1118963000831	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963000832	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963000833	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1118963000834	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1118963000835	short chain dehydrogenase; Provisional; Region: PRK08265
1118963000836	classical (c) SDRs; Region: SDR_c; cd05233
1118963000837	NAD(P) binding site [chemical binding]; other site
1118963000838	active site
1118963000839	AraC-binding-like domain; Region: AraC_binding_2; pfam14525
1118963000840	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963000841	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1118963000842	MarR family; Region: MarR_2; cl17246
1118963000843	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1118963000844	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963000845	DNA-binding site [nucleotide binding]; DNA binding site
1118963000846	FCD domain; Region: FCD; pfam07729
1118963000847	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963000848	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1118963000849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1118963000850	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1118963000851	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1118963000852	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
1118963000853	putative transporter; Provisional; Region: PRK09821
1118963000854	GntP family permease; Region: GntP_permease; pfam02447
1118963000855	Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116
1118963000856	active site
1118963000857	intersubunit interface [polypeptide binding]; other site
1118963000858	zinc binding site [ion binding]; other site
1118963000859	Na+ binding site [ion binding]; other site
1118963000860	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1118963000861	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1118963000862	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1118963000863	GCN5-related N-acetyl-transferase; Region: Acetyltransf_CG; pfam14542
1118963000864	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1118963000865	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963000866	Putative zinc-finger; Region: zf-HC2; pfam13490
1118963000867	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1118963000868	Domain of unknown function DUF11; Region: DUF11; cl17728
1118963000869	envelope glycoprotein I; Provisional; Region: PHA03292
1118963000870	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1118963000871	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963000872	catalytic residue [active]
1118963000873	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
1118963000874	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963000875	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1118963000876	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1118963000877	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1118963000878	IucA / IucC family; Region: IucA_IucC; pfam04183
1118963000879	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1118963000880	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1118963000881	classical (c) SDRs; Region: SDR_c; cd05233
1118963000882	NAD(P) binding site [chemical binding]; other site
1118963000883	active site
1118963000884	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1118963000885	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
1118963000886	putative hydrophobic ligand binding site [chemical binding]; other site
1118963000887	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963000888	Coenzyme A binding pocket [chemical binding]; other site
1118963000889	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1118963000890	putative dimer interface [polypeptide binding]; other site
1118963000891	ligand binding site [chemical binding]; other site
1118963000892	Zn binding site [ion binding]; other site
1118963000893	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
1118963000894	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1118963000895	EamA-like transporter family; Region: EamA; pfam00892
1118963000896	EamA-like transporter family; Region: EamA; pfam00892
1118963000897	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1118963000898	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963000899	DNA-binding site [nucleotide binding]; DNA binding site
1118963000900	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963000901	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963000902	homodimer interface [polypeptide binding]; other site
1118963000903	catalytic residue [active]
1118963000904	proline/glycine betaine transporter; Provisional; Region: PRK10642
1118963000905	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963000906	putative substrate translocation pore; other site
1118963000907	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1118963000908	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963000909	S-adenosylmethionine binding site [chemical binding]; other site
1118963000910	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
1118963000911	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
1118963000912	nucleotide binding site [chemical binding]; other site
1118963000913	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
1118963000914	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1118963000915	active site
1118963000916	DNA binding site [nucleotide binding]
1118963000917	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1118963000918	DNA binding site [nucleotide binding]
1118963000919	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
1118963000920	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1118963000921	putative DNA binding site [nucleotide binding]; other site
1118963000922	putative homodimer interface [polypeptide binding]; other site
1118963000923	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1118963000924	Ferritin-like domain; Region: Ferritin; pfam00210
1118963000925	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1118963000926	dimerization interface [polypeptide binding]; other site
1118963000927	DPS ferroxidase diiron center [ion binding]; other site
1118963000928	ion pore; other site
1118963000929	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
1118963000930	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
1118963000931	active site
1118963000932	DNA binding site [nucleotide binding]
1118963000933	Int/Topo IB signature motif; other site
1118963000934	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1118963000935	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1118963000936	dimerization domain swap beta strand [polypeptide binding]; other site
1118963000937	regulatory protein interface [polypeptide binding]; other site
1118963000938	active site
1118963000939	regulatory phosphorylation site [posttranslational modification]; other site
1118963000940	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1118963000941	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1118963000942	active site
1118963000943	phosphorylation site [posttranslational modification]
1118963000944	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1118963000945	active site
1118963000946	P-loop; other site
1118963000947	phosphorylation site [posttranslational modification]
1118963000948	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1118963000949	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1118963000950	putative substrate binding site [chemical binding]; other site
1118963000951	putative ATP binding site [chemical binding]; other site
1118963000952	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1118963000953	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1118963000954	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1118963000955	GAF domain; Region: GAF; pfam01590
1118963000956	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1118963000957	carboxylate-amine ligase; Provisional; Region: PRK13517
1118963000958	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1118963000959	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963000960	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1118963000961	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963000962	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963000963	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1118963000964	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963000965	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963000966	DNA binding site [nucleotide binding]
1118963000967	domain linker motif; other site
1118963000968	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963000969	dimerization interface [polypeptide binding]; other site
1118963000970	ligand binding site [chemical binding]; other site
1118963000971	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1118963000972	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1118963000973	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963000974	motif II; other site
1118963000975	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1118963000976	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1118963000977	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1118963000978	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1118963000979	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963000980	putative transporter; Provisional; Region: PRK10504
1118963000981	putative substrate translocation pore; other site
1118963000982	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963000983	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963000984	putative Zn2+ binding site [ion binding]; other site
1118963000985	putative DNA binding site [nucleotide binding]; other site
1118963000986	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1118963000987	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963000988	S-adenosylmethionine binding site [chemical binding]; other site
1118963000989	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1118963000990	active site
1118963000991	dimer interface [polypeptide binding]; other site
1118963000992	motif 2; other site
1118963000993	motif 3; other site
1118963000994	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
1118963000995	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1118963000996	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963000997	active site
1118963000998	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963000999	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963001000	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
1118963001001	UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_4; cd13966
1118963001002	putative active site [active]
1118963001003	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
1118963001004	phytoene desaturase; Region: crtI_fam; TIGR02734
1118963001005	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1118963001006	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1118963001007	substrate binding pocket [chemical binding]; other site
1118963001008	substrate-Mg2+ binding site; other site
1118963001009	aspartate-rich region 1; other site
1118963001010	aspartate-rich region 2; other site
1118963001011	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1118963001012	substrate binding pocket [chemical binding]; other site
1118963001013	chain length determination region; other site
1118963001014	substrate-Mg2+ binding site; other site
1118963001015	catalytic residues [active]
1118963001016	aspartate-rich region 1; other site
1118963001017	active site lid residues [active]
1118963001018	aspartate-rich region 2; other site
1118963001019	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
1118963001020	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1118963001021	active site
1118963001022	metal binding site [ion binding]; metal-binding site
1118963001023	nudix motif; other site
1118963001024	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963001025	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963001026	CAAX protease self-immunity; Region: Abi; pfam02517
1118963001027	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1118963001028	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1118963001029	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1118963001030	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1118963001031	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
1118963001032	active site
1118963001033	catalytic triad [active]
1118963001034	oxyanion hole [active]
1118963001035	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
1118963001036	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963001037	non-specific DNA binding site [nucleotide binding]; other site
1118963001038	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1118963001039	sequence-specific DNA binding site [nucleotide binding]; other site
1118963001040	salt bridge; other site
1118963001041	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1118963001042	thiamine pyrophosphate protein; Provisional; Region: PRK08273
1118963001043	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1118963001044	PYR/PP interface [polypeptide binding]; other site
1118963001045	dimer interface [polypeptide binding]; other site
1118963001046	tetramer interface [polypeptide binding]; other site
1118963001047	TPP binding site [chemical binding]; other site
1118963001048	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1118963001049	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1118963001050	TPP-binding site [chemical binding]; other site
1118963001051	GAF domain; Region: GAF_2; pfam13185
1118963001052	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1118963001053	META domain; Region: META; cl01245
1118963001054	glutaminase; Reviewed; Region: PRK12356
1118963001055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963001056	H+ Antiporter protein; Region: 2A0121; TIGR00900
1118963001057	putative substrate translocation pore; other site
1118963001058	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1118963001059	putative active site [active]
1118963001060	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
1118963001061	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1118963001062	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
1118963001063	putative dimer interface [polypeptide binding]; other site
1118963001064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827
1118963001065	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1118963001066	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1118963001067	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1118963001068	active site
1118963001069	catalytic site [active]
1118963001070	Predicted membrane protein [Function unknown]; Region: COG4270
1118963001071	AzlC protein; Region: AzlC; pfam03591
1118963001072	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963001073	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963001074	Domain of unknown function DUF77; Region: DUF77; pfam01910
1118963001075	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1118963001076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963001077	S-adenosylmethionine binding site [chemical binding]; other site
1118963001078	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1118963001079	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963001080	Coenzyme A binding pocket [chemical binding]; other site
1118963001081	Cupin-like domain; Region: Cupin_8; cl19305
1118963001082	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1118963001083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1118963001084	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1118963001085	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1118963001086	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963001087	Walker A/P-loop; other site
1118963001088	ATP binding site [chemical binding]; other site
1118963001089	Q-loop/lid; other site
1118963001090	ABC transporter signature motif; other site
1118963001091	Walker B; other site
1118963001092	D-loop; other site
1118963001093	H-loop/switch region; other site
1118963001094	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1118963001095	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1118963001096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963001097	Q-loop/lid; other site
1118963001098	ABC transporter signature motif; other site
1118963001099	Walker B; other site
1118963001100	D-loop; other site
1118963001101	H-loop/switch region; other site
1118963001102	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1118963001103	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963001104	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1118963001105	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1118963001106	intersubunit interface [polypeptide binding]; other site
1118963001107	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1118963001108	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1118963001109	FAD binding pocket [chemical binding]; other site
1118963001110	FAD binding motif [chemical binding]; other site
1118963001111	phosphate binding motif [ion binding]; other site
1118963001112	NAD binding pocket [chemical binding]; other site
1118963001113	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1118963001114	ABC-ATPase subunit  interface; other site
1118963001115	dimer interface [polypeptide binding]; other site
1118963001116	putative PBP binding regions; other site
1118963001117	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1118963001118	ABC-ATPase subunit  interface; other site
1118963001119	dimer interface [polypeptide binding]; other site
1118963001120	putative PBP binding regions; other site
1118963001121	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1118963001122	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1118963001123	Walker A/P-loop; other site
1118963001124	ATP binding site [chemical binding]; other site
1118963001125	Q-loop/lid; other site
1118963001126	ABC transporter signature motif; other site
1118963001127	Walker B; other site
1118963001128	D-loop; other site
1118963001129	H-loop/switch region; other site
1118963001130	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963001131	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963001132	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1118963001133	dimerization interface [polypeptide binding]; other site
1118963001134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963001135	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963001136	putative substrate translocation pore; other site
1118963001137	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963001138	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
1118963001139	NAD(P) binding site [chemical binding]; other site
1118963001140	active site
1118963001141	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1118963001142	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963001143	active site
1118963001144	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1118963001145	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963001146	Short repeats of unknown function; Region: ALF; pfam03752
1118963001147	Short repeats of unknown function; Region: ALF; pfam03752
1118963001148	Short repeats of unknown function; Region: ALF; pfam03752
1118963001149	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963001150	putative DNA binding site [nucleotide binding]; other site
1118963001151	dimerization interface [polypeptide binding]; other site
1118963001152	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963001153	putative Zn2+ binding site [ion binding]; other site
1118963001154	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963001155	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1118963001156	putative hydrophobic ligand binding site [chemical binding]; other site
1118963001157	urocanate hydratase; Provisional; Region: PRK05414
1118963001158	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
1118963001159	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1118963001160	active sites [active]
1118963001161	tetramer interface [polypeptide binding]; other site
1118963001162	NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902
1118963001163	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1118963001164	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1118963001165	CopC domain; Region: CopC; pfam04234
1118963001166	NlpC/P60 family; Region: NLPC_P60; cl17555
1118963001167	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963001168	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1118963001169	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963001170	Ligand Binding Site [chemical binding]; other site
1118963001171	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963001172	Ligand Binding Site [chemical binding]; other site
1118963001173	phosphoenolpyruvate synthase; Validated; Region: PRK06241
1118963001174	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1118963001175	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1118963001176	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1118963001177	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
1118963001178	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1118963001179	putative substrate binding site [chemical binding]; other site
1118963001180	putative ATP binding site [chemical binding]; other site
1118963001181	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1118963001182	EamA-like transporter family; Region: EamA; pfam00892
1118963001183	EamA-like transporter family; Region: EamA; pfam00892
1118963001184	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1118963001185	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
1118963001186	DsrE/DsrF-like family; Region: DrsE; cl00672
1118963001187	Domain of unknown function DUF302; Region: DUF302; pfam03625
1118963001188	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1118963001189	putative homodimer interface [polypeptide binding]; other site
1118963001190	putative homotetramer interface [polypeptide binding]; other site
1118963001191	putative allosteric switch controlling residues; other site
1118963001192	putative metal binding site [ion binding]; other site
1118963001193	putative homodimer-homodimer interface [polypeptide binding]; other site
1118963001194	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1118963001195	active site residue [active]
1118963001196	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1118963001197	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1118963001198	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1118963001199	active site residue [active]
1118963001200	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1118963001201	active site residue [active]
1118963001202	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1118963001203	catalytic residues [active]
1118963001204	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1118963001205	active site residue [active]
1118963001206	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1118963001207	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1118963001208	active site residue [active]
1118963001209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963001210	putative substrate translocation pore; other site
1118963001211	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963001212	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
1118963001213	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1118963001214	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1118963001215	putative active site [active]
1118963001216	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1118963001217	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1118963001218	substrate binding site [chemical binding]; other site
1118963001219	ATP binding site [chemical binding]; other site
1118963001220	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963001221	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963001222	DNA binding site [nucleotide binding]
1118963001223	domain linker motif; other site
1118963001224	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963001225	dimerization interface [polypeptide binding]; other site
1118963001226	ligand binding site [chemical binding]; other site
1118963001227	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963001228	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963001229	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963001230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001231	dimer interface [polypeptide binding]; other site
1118963001232	conserved gate region; other site
1118963001233	putative PBP binding loops; other site
1118963001234	ABC-ATPase subunit interface; other site
1118963001235	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963001236	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001237	dimer interface [polypeptide binding]; other site
1118963001238	conserved gate region; other site
1118963001239	putative PBP binding loops; other site
1118963001240	ABC-ATPase subunit interface; other site
1118963001241	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
1118963001242	Asp23 family; Region: Asp23; pfam03780
1118963001243	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
1118963001244	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
1118963001245	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
1118963001246	active site
1118963001247	putative catalytic site [active]
1118963001248	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1118963001249	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963001250	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1118963001251	DNA binding residues [nucleotide binding]
1118963001252	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1118963001253	active site
1118963001254	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1118963001255	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963001256	non-specific DNA binding site [nucleotide binding]; other site
1118963001257	salt bridge; other site
1118963001258	sequence-specific DNA binding site [nucleotide binding]; other site
1118963001259	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963001260	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963001261	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963001262	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001263	dimer interface [polypeptide binding]; other site
1118963001264	conserved gate region; other site
1118963001265	putative PBP binding loops; other site
1118963001266	ABC-ATPase subunit interface; other site
1118963001267	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963001268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001269	dimer interface [polypeptide binding]; other site
1118963001270	conserved gate region; other site
1118963001271	putative PBP binding loops; other site
1118963001272	ABC-ATPase subunit interface; other site
1118963001273	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963001274	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963001275	DNA binding site [nucleotide binding]
1118963001276	domain linker motif; other site
1118963001277	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963001278	dimerization interface [polypeptide binding]; other site
1118963001279	ligand binding site [chemical binding]; other site
1118963001280	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1118963001281	putative catalytic site [active]
1118963001282	putative phosphate binding site [ion binding]; other site
1118963001283	active site
1118963001284	metal binding site A [ion binding]; metal-binding site
1118963001285	DNA binding site [nucleotide binding]
1118963001286	putative AP binding site [nucleotide binding]; other site
1118963001287	putative metal binding site B [ion binding]; other site
1118963001288	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1118963001289	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963001290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963001291	active site
1118963001292	phosphorylation site [posttranslational modification]
1118963001293	intermolecular recognition site; other site
1118963001294	dimerization interface [polypeptide binding]; other site
1118963001295	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963001296	DNA binding residues [nucleotide binding]
1118963001297	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1118963001298	Histidine kinase; Region: HisKA_3; pfam07730
1118963001299	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963001300	ATP binding site [chemical binding]; other site
1118963001301	G-X-G motif; other site
1118963001302	Domain of unknown function (DUF336); Region: DUF336; pfam03928
1118963001303	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1118963001304	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1118963001305	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1118963001306	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
1118963001307	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1118963001308	active site
1118963001309	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1118963001310	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1118963001311	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963001312	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963001313	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963001314	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963001315	Coenzyme A binding pocket [chemical binding]; other site
1118963001316	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1118963001317	Fasciclin domain; Region: Fasciclin; pfam02469
1118963001318	BCCT family transporter; Region: BCCT; pfam02028
1118963001319	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963001320	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963001321	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963001322	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1118963001323	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1118963001324	dimer interface [polypeptide binding]; other site
1118963001325	putative functional site; other site
1118963001326	putative MPT binding site; other site
1118963001327	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
1118963001328	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
1118963001329	NAD binding site [chemical binding]; other site
1118963001330	catalytic Zn binding site [ion binding]; other site
1118963001331	structural Zn binding site [ion binding]; other site
1118963001332	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1118963001333	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1118963001334	putative molybdopterin cofactor binding site [chemical binding]; other site
1118963001335	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1118963001336	putative molybdopterin cofactor binding site; other site
1118963001337	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1118963001338	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
1118963001339	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1118963001340	homodimer interface [polypeptide binding]; other site
1118963001341	NADP binding site [chemical binding]; other site
1118963001342	substrate binding site [chemical binding]; other site
1118963001343	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
1118963001344	FAD dependent oxidoreductase; Region: DAO; pfam01266
1118963001345	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
1118963001346	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963001347	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1118963001348	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1118963001349	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1118963001350	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1118963001351	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1118963001352	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1118963001353	putative active site [active]
1118963001354	putative substrate binding site [chemical binding]; other site
1118963001355	putative cosubstrate binding site; other site
1118963001356	catalytic site [active]
1118963001357	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1118963001358	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963001359	DNA-binding site [nucleotide binding]; DNA binding site
1118963001360	FCD domain; Region: FCD; pfam07729
1118963001361	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1118963001362	active site
1118963001363	multimer interface [polypeptide binding]; other site
1118963001364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963001365	benzoate transport; Region: 2A0115; TIGR00895
1118963001366	putative substrate translocation pore; other site
1118963001367	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963001368	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963001369	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1118963001370	putative dimerization interface [polypeptide binding]; other site
1118963001371	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1118963001372	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1118963001373	[2Fe-2S] cluster binding site [ion binding]; other site
1118963001374	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
1118963001375	putative alpha subunit interface [polypeptide binding]; other site
1118963001376	putative active site [active]
1118963001377	putative substrate binding site [chemical binding]; other site
1118963001378	Fe binding site [ion binding]; other site
1118963001379	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1118963001380	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1118963001381	FAD binding pocket [chemical binding]; other site
1118963001382	FAD binding motif [chemical binding]; other site
1118963001383	phosphate binding motif [ion binding]; other site
1118963001384	beta-alpha-beta structure motif; other site
1118963001385	NAD binding pocket [chemical binding]; other site
1118963001386	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1118963001387	catalytic loop [active]
1118963001388	iron binding site [ion binding]; other site
1118963001389	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1118963001390	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963001391	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963001392	DNA binding residues [nucleotide binding]
1118963001393	dimerization interface [polypeptide binding]; other site
1118963001394	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1118963001395	tetramer interface [polypeptide binding]; other site
1118963001396	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1118963001397	active site
1118963001398	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1118963001399	active site
1118963001400	dimer interface [polypeptide binding]; other site
1118963001401	magnesium binding site [ion binding]; other site
1118963001402	N-terminal domain of (some) glycogen debranching enzymes; Region: GDE_N_bis; pfam14742
1118963001403	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1118963001404	Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168
1118963001405	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1118963001406	DNA photolyase; Region: DNA_photolyase; pfam00875
1118963001407	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
1118963001408	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1118963001409	tetrameric interface [polypeptide binding]; other site
1118963001410	NAD binding site [chemical binding]; other site
1118963001411	catalytic residues [active]
1118963001412	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1118963001413	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1118963001414	substrate binding site [chemical binding]; other site
1118963001415	oxyanion hole (OAH) forming residues; other site
1118963001416	trimer interface [polypeptide binding]; other site
1118963001417	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1118963001418	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1118963001419	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1118963001420	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
1118963001421	enoyl-CoA hydratase; Provisional; Region: PRK05862
1118963001422	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1118963001423	substrate binding site [chemical binding]; other site
1118963001424	oxyanion hole (OAH) forming residues; other site
1118963001425	trimer interface [polypeptide binding]; other site
1118963001426	RibD C-terminal domain; Region: RibD_C; cl17279
1118963001427	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1118963001428	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963001429	Ligand Binding Site [chemical binding]; other site
1118963001430	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963001431	Ligand Binding Site [chemical binding]; other site
1118963001432	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1118963001433	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963001434	active site
1118963001435	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963001436	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1118963001437	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1118963001438	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1118963001439	acyl-activating enzyme (AAE) consensus motif; other site
1118963001440	AMP binding site [chemical binding]; other site
1118963001441	active site
1118963001442	CoA binding site [chemical binding]; other site
1118963001443	acyl-coenzyme A oxidase; Region: PLN02526
1118963001444	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1118963001445	active site
1118963001446	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
1118963001447	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963001448	choline dehydrogenase; Validated; Region: PRK02106
1118963001449	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963001450	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1118963001451	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1118963001452	NAD(P) binding site [chemical binding]; other site
1118963001453	catalytic residues [active]
1118963001454	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1118963001455	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1118963001456	Moco binding site; other site
1118963001457	metal coordination site [ion binding]; other site
1118963001458	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963001459	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963001460	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1118963001461	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1118963001462	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1118963001463	DNA binding residues [nucleotide binding]
1118963001464	dimer interface [polypeptide binding]; other site
1118963001465	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1118963001466	Predicted transcriptional regulators [Transcription]; Region: COG1695
1118963001467	dimerization interface [polypeptide binding]; other site
1118963001468	putative DNA binding site [nucleotide binding]; other site
1118963001469	putative Zn2+ binding site [ion binding]; other site
1118963001470	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1118963001471	homodimer interface [polypeptide binding]; other site
1118963001472	NAD binding pocket [chemical binding]; other site
1118963001473	ATP binding pocket [chemical binding]; other site
1118963001474	Mg binding site [ion binding]; other site
1118963001475	active-site loop [active]
1118963001476	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963001477	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963001478	DNA binding site [nucleotide binding]
1118963001479	domain linker motif; other site
1118963001480	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963001481	ligand binding site [chemical binding]; other site
1118963001482	dimerization interface [polypeptide binding]; other site
1118963001483	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963001484	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963001485	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1118963001486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001487	dimer interface [polypeptide binding]; other site
1118963001488	conserved gate region; other site
1118963001489	putative PBP binding loops; other site
1118963001490	ABC-ATPase subunit interface; other site
1118963001491	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963001492	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001493	dimer interface [polypeptide binding]; other site
1118963001494	conserved gate region; other site
1118963001495	putative PBP binding loops; other site
1118963001496	ABC-ATPase subunit interface; other site
1118963001497	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963001498	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963001499	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963001500	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963001501	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963001502	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963001503	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963001504	glucuronate isomerase; Reviewed; Region: PRK02925
1118963001505	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1118963001506	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1118963001507	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1118963001508	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
1118963001509	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1118963001510	metal binding site [ion binding]; metal-binding site
1118963001511	substrate binding pocket [chemical binding]; other site
1118963001512	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1118963001513	AAA domain; Region: AAA_33; pfam13671
1118963001514	ATP-binding site [chemical binding]; other site
1118963001515	Gluconate-6-phosphate binding site [chemical binding]; other site
1118963001516	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1118963001517	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1118963001518	putative ligand binding site [chemical binding]; other site
1118963001519	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1118963001520	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1118963001521	Walker A/P-loop; other site
1118963001522	ATP binding site [chemical binding]; other site
1118963001523	Q-loop/lid; other site
1118963001524	ABC transporter signature motif; other site
1118963001525	Walker B; other site
1118963001526	D-loop; other site
1118963001527	H-loop/switch region; other site
1118963001528	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1118963001529	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1118963001530	TM-ABC transporter signature motif; other site
1118963001531	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963001532	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963001533	DNA binding site [nucleotide binding]
1118963001534	domain linker motif; other site
1118963001535	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
1118963001536	ligand binding site [chemical binding]; other site
1118963001537	dimerization interface (open form) [polypeptide binding]; other site
1118963001538	dimerization interface (closed form) [polypeptide binding]; other site
1118963001539	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1118963001540	active site
1118963001541	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963001542	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963001543	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1118963001544	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963001545	Walker A/P-loop; other site
1118963001546	ATP binding site [chemical binding]; other site
1118963001547	Q-loop/lid; other site
1118963001548	ABC transporter signature motif; other site
1118963001549	Walker B; other site
1118963001550	D-loop; other site
1118963001551	H-loop/switch region; other site
1118963001552	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1118963001553	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1118963001554	active site
1118963001555	ATP binding site [chemical binding]; other site
1118963001556	Phosphotransferase enzyme family; Region: APH; pfam01636
1118963001557	Flavoprotein; Region: Flavoprotein; pfam02441
1118963001558	Phosphotransferase enzyme family; Region: APH; pfam01636
1118963001559	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1118963001560	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1118963001561	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963001562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963001563	active site
1118963001564	phosphorylation site [posttranslational modification]
1118963001565	intermolecular recognition site; other site
1118963001566	dimerization interface [polypeptide binding]; other site
1118963001567	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963001568	DNA binding residues [nucleotide binding]
1118963001569	dimerization interface [polypeptide binding]; other site
1118963001570	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1118963001571	Histidine kinase; Region: HisKA_3; pfam07730
1118963001572	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1118963001573	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1118963001574	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963001575	UMP phosphatase; Provisional; Region: PRK10444
1118963001576	active site
1118963001577	motif I; other site
1118963001578	motif II; other site
1118963001579	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1118963001580	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1118963001581	active site
1118963001582	intersubunit interface [polypeptide binding]; other site
1118963001583	zinc binding site [ion binding]; other site
1118963001584	Na+ binding site [ion binding]; other site
1118963001585	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
1118963001586	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1118963001587	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1118963001588	Walker A/P-loop; other site
1118963001589	ATP binding site [chemical binding]; other site
1118963001590	Q-loop/lid; other site
1118963001591	ABC transporter signature motif; other site
1118963001592	Walker B; other site
1118963001593	D-loop; other site
1118963001594	H-loop/switch region; other site
1118963001595	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1118963001596	ABC-ATPase subunit  interface; other site
1118963001597	dimer interface [polypeptide binding]; other site
1118963001598	putative PBP binding regions; other site
1118963001599	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1118963001600	ABC-ATPase subunit  interface; other site
1118963001601	dimer interface [polypeptide binding]; other site
1118963001602	putative PBP binding regions; other site
1118963001603	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1118963001604	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1118963001605	siderophore binding site; other site
1118963001606	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1118963001607	ligand binding site [chemical binding]; other site
1118963001608	active site
1118963001609	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1118963001610	GDP-binding site [chemical binding]; other site
1118963001611	ACT binding site; other site
1118963001612	IMP binding site; other site
1118963001613	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
1118963001614	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1118963001615	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963001616	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1118963001617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963001618	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963001619	putative substrate translocation pore; other site
1118963001620	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1118963001621	Strictosidine synthase; Region: Str_synth; cl19733
1118963001622	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263
1118963001623	L-aspartate oxidase; Provisional; Region: PRK06175
1118963001624	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1118963001625	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963001626	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963001627	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1118963001628	dimerization interface [polypeptide binding]; other site
1118963001629	malate dehydrogenase; Provisional; Region: PRK05442
1118963001630	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1118963001631	NAD(P) binding site [chemical binding]; other site
1118963001632	dimer interface [polypeptide binding]; other site
1118963001633	malate binding site [chemical binding]; other site
1118963001634	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1118963001635	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963001636	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1118963001637	Aspartase; Region: Aspartase; cd01357
1118963001638	active sites [active]
1118963001639	tetramer interface [polypeptide binding]; other site
1118963001640	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1118963001641	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1118963001642	metal binding site [ion binding]; metal-binding site
1118963001643	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
1118963001644	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1118963001645	homotrimer interaction site [polypeptide binding]; other site
1118963001646	putative active site [active]
1118963001647	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963001648	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963001649	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
1118963001650	putative substrate binding pocket [chemical binding]; other site
1118963001651	dimerization interface [polypeptide binding]; other site
1118963001652	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963001653	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963001654	putative substrate translocation pore; other site
1118963001655	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1118963001656	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963001657	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1118963001658	tyramine oxidase; Provisional; Region: tynA; PRK11504
1118963001659	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
1118963001660	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
1118963001661	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
1118963001662	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1118963001663	NAD(P) binding site [chemical binding]; other site
1118963001664	catalytic residues [active]
1118963001665	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963001666	Amino acid permease; Region: AA_permease_2; pfam13520
1118963001667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963001668	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963001669	putative substrate translocation pore; other site
1118963001670	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963001671	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963001672	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
1118963001673	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963001674	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963001675	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1118963001676	Protein of unknown function (DUF3494); Region: DUF3494; pfam11999
1118963001677	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
1118963001678	active site
1118963001679	catalytic site [active]
1118963001680	Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl19874
1118963001681	CAAX protease self-immunity; Region: Abi; pfam02517
1118963001682	PHP domain; Region: PHP; pfam02811
1118963001683	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
1118963001684	active site
1118963001685	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963001686	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963001687	DNA binding site [nucleotide binding]
1118963001688	domain linker motif; other site
1118963001689	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963001690	dimerization interface [polypeptide binding]; other site
1118963001691	ligand binding site [chemical binding]; other site
1118963001692	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1118963001693	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1118963001694	substrate binding pocket [chemical binding]; other site
1118963001695	membrane-bound complex binding site; other site
1118963001696	hinge residues; other site
1118963001697	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1118963001698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001699	dimer interface [polypeptide binding]; other site
1118963001700	conserved gate region; other site
1118963001701	putative PBP binding loops; other site
1118963001702	ABC-ATPase subunit interface; other site
1118963001703	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1118963001704	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1118963001705	Walker A/P-loop; other site
1118963001706	ATP binding site [chemical binding]; other site
1118963001707	Q-loop/lid; other site
1118963001708	ABC transporter signature motif; other site
1118963001709	Walker B; other site
1118963001710	D-loop; other site
1118963001711	H-loop/switch region; other site
1118963001712	putative oxidoreductase; Provisional; Region: PRK11579
1118963001713	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963001714	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963001715	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1118963001716	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963001717	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1118963001718	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1118963001719	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1118963001720	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963001721	NAD(P) binding site [chemical binding]; other site
1118963001722	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963001723	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
1118963001724	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
1118963001725	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963001726	active site
1118963001727	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1118963001728	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963001729	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1118963001730	DNA binding residues [nucleotide binding]
1118963001731	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
1118963001732	CoA binding domain; Region: CoA_binding; cl17356
1118963001733	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1118963001734	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1118963001735	NodB motif; other site
1118963001736	active site
1118963001737	catalytic site [active]
1118963001738	metal binding site [ion binding]; metal-binding site
1118963001739	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1118963001740	carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851
1118963001741	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963001742	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963001743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001744	dimer interface [polypeptide binding]; other site
1118963001745	conserved gate region; other site
1118963001746	putative PBP binding loops; other site
1118963001747	ABC-ATPase subunit interface; other site
1118963001748	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963001749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001750	dimer interface [polypeptide binding]; other site
1118963001751	conserved gate region; other site
1118963001752	putative PBP binding loops; other site
1118963001753	ABC-ATPase subunit interface; other site
1118963001754	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1118963001755	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
1118963001756	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1118963001757	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
1118963001758	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1118963001759	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
1118963001760	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1118963001761	putative active site [active]
1118963001762	catalytic triad [active]
1118963001763	putative dimer interface [polypeptide binding]; other site
1118963001764	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963001765	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963001766	putative substrate translocation pore; other site
1118963001767	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1118963001768	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1118963001769	DNA-binding site [nucleotide binding]; DNA binding site
1118963001770	FCD domain; Region: FCD; pfam07729
1118963001771	Protein of unknown function (DUF503); Region: DUF503; pfam04456
1118963001772	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963001773	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
1118963001774	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963001775	homodimer interface [polypeptide binding]; other site
1118963001776	catalytic residue [active]
1118963001777	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1118963001778	metal binding site [ion binding]; metal-binding site
1118963001779	active site
1118963001780	I-site; other site
1118963001781	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1118963001782	metal binding site [ion binding]; metal-binding site
1118963001783	active site
1118963001784	I-site; other site
1118963001785	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1118963001786	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1118963001787	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1118963001788	dimerization interface [polypeptide binding]; other site
1118963001789	ATP binding site [chemical binding]; other site
1118963001790	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1118963001791	dimerization interface [polypeptide binding]; other site
1118963001792	ATP binding site [chemical binding]; other site
1118963001793	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1118963001794	putative active site [active]
1118963001795	catalytic triad [active]
1118963001796	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1118963001797	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1118963001798	dimanganese center [ion binding]; other site
1118963001799	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_3; cd12160
1118963001800	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1118963001801	putative ligand binding site [chemical binding]; other site
1118963001802	putative NAD binding site [chemical binding]; other site
1118963001803	catalytic site [active]
1118963001804	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
1118963001805	catalytic site [active]
1118963001806	BNR repeat-like domain; Region: BNR_2; pfam13088
1118963001807	Asp-box motif; other site
1118963001808	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
1118963001809	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1118963001810	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1118963001811	active site
1118963001812	catalytic residues [active]
1118963001813	PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120
1118963001814	PA/protease or protease-like domain interface [polypeptide binding]; other site
1118963001815	Subtilisin inhibitor-like; Region: SSI; cl11594
1118963001816	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1118963001817	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963001818	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963001819	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963001820	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963001821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001822	dimer interface [polypeptide binding]; other site
1118963001823	conserved gate region; other site
1118963001824	putative PBP binding loops; other site
1118963001825	ABC-ATPase subunit interface; other site
1118963001826	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1118963001827	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963001828	Walker A/P-loop; other site
1118963001829	ATP binding site [chemical binding]; other site
1118963001830	Q-loop/lid; other site
1118963001831	ABC transporter signature motif; other site
1118963001832	Walker B; other site
1118963001833	D-loop; other site
1118963001834	H-loop/switch region; other site
1118963001835	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1118963001836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001837	dimer interface [polypeptide binding]; other site
1118963001838	conserved gate region; other site
1118963001839	putative PBP binding loops; other site
1118963001840	ABC-ATPase subunit interface; other site
1118963001841	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1118963001842	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
1118963001843	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1118963001844	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1118963001845	active site pocket [active]
1118963001846	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1118963001847	NAD(P) binding site [chemical binding]; other site
1118963001848	catalytic residues [active]
1118963001849	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1118963001850	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1118963001851	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
1118963001852	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1118963001853	active site
1118963001854	NAD binding site [chemical binding]; other site
1118963001855	metal binding site [ion binding]; metal-binding site
1118963001856	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1118963001857	tetramerization interface [polypeptide binding]; other site
1118963001858	NAD(P) binding site [chemical binding]; other site
1118963001859	catalytic residues [active]
1118963001860	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1118963001861	classical (c) SDRs; Region: SDR_c; cd05233
1118963001862	NAD(P) binding site [chemical binding]; other site
1118963001863	active site
1118963001864	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1118963001865	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1118963001866	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1118963001867	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1118963001868	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963001869	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963001870	putative substrate translocation pore; other site
1118963001871	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963001872	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963001873	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1118963001874	aspartate kinase; Reviewed; Region: PRK06635
1118963001875	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1118963001876	putative nucleotide binding site [chemical binding]; other site
1118963001877	putative catalytic residues [active]
1118963001878	putative Mg ion binding site [ion binding]; other site
1118963001879	putative aspartate binding site [chemical binding]; other site
1118963001880	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1118963001881	putative allosteric regulatory site; other site
1118963001882	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
1118963001883	Domain of unknown function (DUF427); Region: DUF427; pfam04248
1118963001884	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
1118963001885	NADP+ binding site [chemical binding]; other site
1118963001886	folate binding site [chemical binding]; other site
1118963001887	recombination protein RecR; Reviewed; Region: recR; PRK00076
1118963001888	RecR protein; Region: RecR; pfam02132
1118963001889	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1118963001890	putative active site [active]
1118963001891	putative metal-binding site [ion binding]; other site
1118963001892	tetramer interface [polypeptide binding]; other site
1118963001893	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
1118963001894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963001895	Walker A motif; other site
1118963001896	ATP binding site [chemical binding]; other site
1118963001897	Walker B motif; other site
1118963001898	arginine finger; other site
1118963001899	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1118963001900	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
1118963001901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1118963001902	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
1118963001903	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963001904	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963001905	putative DNA binding site [nucleotide binding]; other site
1118963001906	dimerization interface [polypeptide binding]; other site
1118963001907	putative Zn2+ binding site [ion binding]; other site
1118963001908	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963001909	dimerization interface [polypeptide binding]; other site
1118963001910	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1118963001911	Proline dehydrogenase; Region: Pro_dh; pfam01619
1118963001912	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1118963001913	NAD(P) binding site [chemical binding]; other site
1118963001914	catalytic residues [active]
1118963001915	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
1118963001916	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963001917	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963001918	putative substrate translocation pore; other site
1118963001919	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963001920	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963001921	dimerization interface [polypeptide binding]; other site
1118963001922	putative Zn2+ binding site [ion binding]; other site
1118963001923	putative DNA binding site [nucleotide binding]; other site
1118963001924	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1118963001925	Peptidase family M23; Region: Peptidase_M23; pfam01551
1118963001926	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1118963001927	catalytic residues [active]
1118963001928	dimer interface [polypeptide binding]; other site
1118963001929	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1118963001930	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1118963001931	active site
1118963001932	metal binding site [ion binding]; metal-binding site
1118963001933	hexamer interface [polypeptide binding]; other site
1118963001934	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
1118963001935	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
1118963001936	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1118963001937	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1118963001938	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963001939	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963001940	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963001941	DNA binding site [nucleotide binding]
1118963001942	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963001943	domain linker motif; other site
1118963001944	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963001945	dimerization interface [polypeptide binding]; other site
1118963001946	ligand binding site [chemical binding]; other site
1118963001947	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963001948	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1118963001949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001950	dimer interface [polypeptide binding]; other site
1118963001951	conserved gate region; other site
1118963001952	putative PBP binding loops; other site
1118963001953	ABC-ATPase subunit interface; other site
1118963001954	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963001955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001956	dimer interface [polypeptide binding]; other site
1118963001957	conserved gate region; other site
1118963001958	putative PBP binding loops; other site
1118963001959	ABC-ATPase subunit interface; other site
1118963001960	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1118963001961	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1118963001962	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1118963001963	catalytic residues [active]
1118963001964	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1118963001965	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1118963001966	putative ADP-binding pocket [chemical binding]; other site
1118963001967	N-terminal domain of (some) glycogen debranching enzymes; Region: GDE_N_bis; pfam14742
1118963001968	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1118963001969	Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168
1118963001970	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1118963001971	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963001972	Coenzyme A binding pocket [chemical binding]; other site
1118963001973	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1118963001974	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1118963001975	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1118963001976	substrate binding [chemical binding]; other site
1118963001977	active site
1118963001978	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1118963001979	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1118963001980	putative substrate binding site [chemical binding]; other site
1118963001981	putative ATP binding site [chemical binding]; other site
1118963001982	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963001983	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963001984	DNA binding site [nucleotide binding]
1118963001985	domain linker motif; other site
1118963001986	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
1118963001987	putative dimerization interface [polypeptide binding]; other site
1118963001988	putative ligand binding site [chemical binding]; other site
1118963001989	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
1118963001990	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963001991	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001992	dimer interface [polypeptide binding]; other site
1118963001993	conserved gate region; other site
1118963001994	putative PBP binding loops; other site
1118963001995	ABC-ATPase subunit interface; other site
1118963001996	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963001997	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963001998	dimer interface [polypeptide binding]; other site
1118963001999	conserved gate region; other site
1118963002000	putative PBP binding loops; other site
1118963002001	ABC-ATPase subunit interface; other site
1118963002002	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963002003	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963002004	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
1118963002005	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963002006	Ligand Binding Site [chemical binding]; other site
1118963002007	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
1118963002008	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1118963002009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1118963002010	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1118963002011	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
1118963002012	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1118963002013	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
1118963002014	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963002015	ATP binding site [chemical binding]; other site
1118963002016	Mg2+ binding site [ion binding]; other site
1118963002017	G-X-G motif; other site
1118963002018	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1118963002019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963002020	active site
1118963002021	phosphorylation site [posttranslational modification]
1118963002022	intermolecular recognition site; other site
1118963002023	dimerization interface [polypeptide binding]; other site
1118963002024	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1118963002025	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1118963002026	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1118963002027	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1118963002028	Domain of unknown function (DUF336); Region: DUF336; cl01249
1118963002029	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963002030	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963002031	translocation protein TolB; Provisional; Region: tolB; PRK02889
1118963002032	translocation protein TolB; Provisional; Region: tolB; PRK02889
1118963002033	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963002034	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963002035	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1118963002036	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963002037	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963002038	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963002039	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963002040	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963002041	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963002042	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963002043	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1118963002044	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963002045	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1118963002046	nucleotide binding site [chemical binding]; other site
1118963002047	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963002048	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1118963002049	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963002050	putative substrate translocation pore; other site
1118963002051	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
1118963002052	active site
1118963002053	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1118963002054	tetramer interface [polypeptide binding]; other site
1118963002055	active site
1118963002056	Mg2+/Mn2+ binding site [ion binding]; other site
1118963002057	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1118963002058	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963002059	non-specific DNA binding site [nucleotide binding]; other site
1118963002060	salt bridge; other site
1118963002061	sequence-specific DNA binding site [nucleotide binding]; other site
1118963002062	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1118963002063	Domain of unknown function (DUF955); Region: DUF955; cl01076
1118963002064	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
1118963002065	reactive center loop; other site
1118963002066	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963002067	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963002068	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
1118963002069	Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292
1118963002070	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1118963002071	dimer interface [polypeptide binding]; other site
1118963002072	substrate binding site [chemical binding]; other site
1118963002073	ATP binding site [chemical binding]; other site
1118963002074	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1118963002075	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1118963002076	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1118963002077	dimerization interface [polypeptide binding]; other site
1118963002078	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1118963002079	dimer interface [polypeptide binding]; other site
1118963002080	phosphorylation site [posttranslational modification]
1118963002081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963002082	ATP binding site [chemical binding]; other site
1118963002083	Mg2+ binding site [ion binding]; other site
1118963002084	G-X-G motif; other site
1118963002085	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1118963002086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963002087	active site
1118963002088	dimerization interface [polypeptide binding]; other site
1118963002089	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1118963002090	DNA binding site [nucleotide binding]
1118963002091	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1118963002092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963002093	putative substrate translocation pore; other site
1118963002094	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963002095	TIGR01777 family protein; Region: yfcH
1118963002096	NAD(P) binding site [chemical binding]; other site
1118963002097	active site
1118963002098	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963002099	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963002100	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
1118963002101	Queuine tRNA-ribosyltransferase; Region: TGT; cl19224
1118963002102	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1118963002103	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1118963002104	putative hydrophobic ligand binding site [chemical binding]; other site
1118963002105	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_long; TIGR01348
1118963002106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1118963002107	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1118963002108	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1118963002109	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1118963002110	Walker A/P-loop; other site
1118963002111	ATP binding site [chemical binding]; other site
1118963002112	Q-loop/lid; other site
1118963002113	ABC transporter signature motif; other site
1118963002114	Walker B; other site
1118963002115	D-loop; other site
1118963002116	H-loop/switch region; other site
1118963002117	TOBE domain; Region: TOBE_2; pfam08402
1118963002118	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1118963002119	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963002120	dimer interface [polypeptide binding]; other site
1118963002121	conserved gate region; other site
1118963002122	putative PBP binding loops; other site
1118963002123	ABC-ATPase subunit interface; other site
1118963002124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963002125	dimer interface [polypeptide binding]; other site
1118963002126	conserved gate region; other site
1118963002127	putative PBP binding loops; other site
1118963002128	ABC-ATPase subunit interface; other site
1118963002129	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1118963002130	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
1118963002131	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
1118963002132	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963002133	NAD(P) binding site [chemical binding]; other site
1118963002134	active site
1118963002135	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
1118963002136	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1118963002137	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963002138	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1118963002139	Putative zinc-finger; Region: zf-HC2; pfam13490
1118963002140	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
1118963002141	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963002142	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1118963002143	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
1118963002144	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1118963002145	DXD motif; other site
1118963002146	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1118963002147	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
1118963002148	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1118963002149	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
1118963002150	putative ADP-ribose binding site [chemical binding]; other site
1118963002151	putative active site [active]
1118963002152	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1118963002153	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1118963002154	active site
1118963002155	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963002156	putative DNA binding site [nucleotide binding]; other site
1118963002157	Winged helix-turn helix; Region: HTH_29; pfam13551
1118963002158	putative Zn2+ binding site [ion binding]; other site
1118963002159	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1118963002160	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963002161	WHG domain; Region: WHG; pfam13305
1118963002162	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
1118963002163	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1118963002164	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963002165	DNA-binding site [nucleotide binding]; DNA binding site
1118963002166	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963002167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963002168	homodimer interface [polypeptide binding]; other site
1118963002169	catalytic residue [active]
1118963002170	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1118963002171	Predicted membrane protein [Function unknown]; Region: COG2364
1118963002172	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1118963002173	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1118963002174	anti sigma factor interaction site; other site
1118963002175	regulatory phosphorylation site [posttranslational modification]; other site
1118963002176	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1118963002177	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1118963002178	DXD motif; other site
1118963002179	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1118963002180	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1118963002181	active site
1118963002182	catalytic residues [active]
1118963002183	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1118963002184	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1118963002185	putative sugar binding sites [chemical binding]; other site
1118963002186	Q-X-W motif; other site
1118963002187	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1118963002188	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
1118963002189	putative DNA binding site [nucleotide binding]; other site
1118963002190	catalytic residue [active]
1118963002191	putative H2TH interface [polypeptide binding]; other site
1118963002192	putative catalytic residues [active]
1118963002193	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1118963002194	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1118963002195	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963002196	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
1118963002197	ATP binding site [chemical binding]; other site
1118963002198	putative Mg++ binding site [ion binding]; other site
1118963002199	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963002200	nucleotide binding region [chemical binding]; other site
1118963002201	ATP-binding site [chemical binding]; other site
1118963002202	DEAD/H associated; Region: DEAD_assoc; pfam08494
1118963002203	Winged helix DNA-binding domain; Region: HTH_42; cl19833
1118963002204	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
1118963002205	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1118963002206	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824
1118963002207	putative hydrophobic ligand binding site [chemical binding]; other site
1118963002208	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
1118963002209	putative NAD(P) binding site [chemical binding]; other site
1118963002210	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1118963002211	active site
1118963002212	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1118963002213	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1118963002214	Winged helix DNA-binding domain; Region: HTH_42; cl19833
1118963002215	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
1118963002216	metal binding site [ion binding]; metal-binding site
1118963002217	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1118963002218	nucleoside/Zn binding site; other site
1118963002219	dimer interface [polypeptide binding]; other site
1118963002220	catalytic motif [active]
1118963002221	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1118963002222	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1118963002223	active site
1118963002224	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1118963002225	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1118963002226	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1118963002227	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963002228	active site
1118963002229	motif I; other site
1118963002230	motif II; other site
1118963002231	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
1118963002232	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963002233	catalytic residue [active]
1118963002234	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
1118963002235	Ligand binding site; other site
1118963002236	Ligand binding site; other site
1118963002237	Ligand binding site; other site
1118963002238	Putative Catalytic site; other site
1118963002239	DXD motif; other site
1118963002240	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1118963002241	catalytic residue [active]
1118963002242	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1118963002243	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
1118963002244	HAMP domain; Region: HAMP; pfam00672
1118963002245	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1118963002246	dimer interface [polypeptide binding]; other site
1118963002247	phosphorylation site [posttranslational modification]
1118963002248	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963002249	ATP binding site [chemical binding]; other site
1118963002250	Mg2+ binding site [ion binding]; other site
1118963002251	G-X-G motif; other site
1118963002252	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1118963002253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963002254	active site
1118963002255	phosphorylation site [posttranslational modification]
1118963002256	intermolecular recognition site; other site
1118963002257	dimerization interface [polypeptide binding]; other site
1118963002258	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1118963002259	DNA binding site [nucleotide binding]
1118963002260	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1118963002261	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1118963002262	DNA binding site [nucleotide binding]
1118963002263	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1118963002264	catalytic core [active]
1118963002265	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963002266	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963002267	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963002268	dimerization interface [polypeptide binding]; other site
1118963002269	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1118963002270	EamA-like transporter family; Region: EamA; pfam00892
1118963002271	EamA-like transporter family; Region: EamA; pfam00892
1118963002272	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
1118963002273	NAD(P) binding site [chemical binding]; other site
1118963002274	catalytic residues [active]
1118963002275	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1118963002276	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963002277	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1118963002278	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1118963002279	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1118963002280	active site
1118963002281	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1118963002282	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1118963002283	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1118963002284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963002285	dimer interface [polypeptide binding]; other site
1118963002286	conserved gate region; other site
1118963002287	putative PBP binding loops; other site
1118963002288	ABC-ATPase subunit interface; other site
1118963002289	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1118963002290	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1118963002291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963002292	dimer interface [polypeptide binding]; other site
1118963002293	conserved gate region; other site
1118963002294	putative PBP binding loops; other site
1118963002295	ABC-ATPase subunit interface; other site
1118963002296	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1118963002297	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963002298	Walker A/P-loop; other site
1118963002299	ATP binding site [chemical binding]; other site
1118963002300	Q-loop/lid; other site
1118963002301	ABC transporter signature motif; other site
1118963002302	Walker B; other site
1118963002303	D-loop; other site
1118963002304	H-loop/switch region; other site
1118963002305	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963002306	Walker A/P-loop; other site
1118963002307	ATP binding site [chemical binding]; other site
1118963002308	Q-loop/lid; other site
1118963002309	ABC transporter signature motif; other site
1118963002310	Walker B; other site
1118963002311	D-loop; other site
1118963002312	H-loop/switch region; other site
1118963002313	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1118963002314	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1118963002315	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1118963002316	Protein of unknown function (DUF2890); Region: DUF2890; pfam11081
1118963002317	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963002318	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963002319	Predicted membrane protein [Function unknown]; Region: COG1511
1118963002320	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1118963002321	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1118963002322	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1118963002323	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963002324	Walker A/P-loop; other site
1118963002325	ATP binding site [chemical binding]; other site
1118963002326	Q-loop/lid; other site
1118963002327	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1118963002328	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963002329	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1118963002330	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1118963002331	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1118963002332	active site residue [active]
1118963002333	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1118963002334	active site residue [active]
1118963002335	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1118963002336	putative active site cavity [active]
1118963002337	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963002338	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1118963002339	nucleotide binding site [chemical binding]; other site
1118963002340	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1118963002341	inhibitor site; inhibition site
1118963002342	active site
1118963002343	dimer interface [polypeptide binding]; other site
1118963002344	catalytic residue [active]
1118963002345	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1118963002346	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963002347	Walker A/P-loop; other site
1118963002348	ATP binding site [chemical binding]; other site
1118963002349	Q-loop/lid; other site
1118963002350	ABC transporter signature motif; other site
1118963002351	Walker B; other site
1118963002352	D-loop; other site
1118963002353	H-loop/switch region; other site
1118963002354	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1118963002355	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1118963002356	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1118963002357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963002358	dimer interface [polypeptide binding]; other site
1118963002359	conserved gate region; other site
1118963002360	putative PBP binding loops; other site
1118963002361	ABC-ATPase subunit interface; other site
1118963002362	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1118963002363	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963002364	Walker A/P-loop; other site
1118963002365	ATP binding site [chemical binding]; other site
1118963002366	Q-loop/lid; other site
1118963002367	ABC transporter signature motif; other site
1118963002368	Walker B; other site
1118963002369	D-loop; other site
1118963002370	H-loop/switch region; other site
1118963002371	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1118963002372	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1118963002373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963002374	dimer interface [polypeptide binding]; other site
1118963002375	conserved gate region; other site
1118963002376	putative PBP binding loops; other site
1118963002377	ABC-ATPase subunit interface; other site
1118963002378	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1118963002379	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1118963002380	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1118963002381	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963002382	DNA-binding site [nucleotide binding]; DNA binding site
1118963002383	FCD domain; Region: FCD; pfam07729
1118963002384	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1118963002385	active site
1118963002386	substrate-binding site [chemical binding]; other site
1118963002387	metal-binding site [ion binding]
1118963002388	GTP binding site [chemical binding]; other site
1118963002389	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1118963002390	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1118963002391	heme-binding site [chemical binding]; other site
1118963002392	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1118963002393	FAD binding pocket [chemical binding]; other site
1118963002394	FAD binding motif [chemical binding]; other site
1118963002395	phosphate binding motif [ion binding]; other site
1118963002396	beta-alpha-beta structure motif; other site
1118963002397	NAD binding pocket [chemical binding]; other site
1118963002398	Heme binding  pocket [chemical binding]; other site
1118963002399	Predicted transcriptional regulator [Transcription]; Region: COG1959
1118963002400	Rrf2 family protein; Region: rrf2_super; TIGR00738
1118963002401	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
1118963002402	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1118963002403	active site
1118963002404	substrate binding site [chemical binding]; other site
1118963002405	metal binding site [ion binding]; metal-binding site
1118963002406	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1118963002407	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963002408	ATP binding site [chemical binding]; other site
1118963002409	putative Mg++ binding site [ion binding]; other site
1118963002410	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963002411	nucleotide binding region [chemical binding]; other site
1118963002412	ATP-binding site [chemical binding]; other site
1118963002413	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1118963002414	active site
1118963002415	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963002416	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963002417	putative substrate translocation pore; other site
1118963002418	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1118963002419	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1118963002420	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1118963002421	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1118963002422	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963002423	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
1118963002424	Lamin Tail Domain; Region: LTD; pfam00932
1118963002425	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1118963002426	generic binding surface II; other site
1118963002427	generic binding surface I; other site
1118963002428	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
1118963002429	putative active site [active]
1118963002430	putative catalytic site [active]
1118963002431	putative Mg binding site IVb [ion binding]; other site
1118963002432	putative phosphate binding site [ion binding]; other site
1118963002433	putative DNA binding site [nucleotide binding]; other site
1118963002434	putative Mg binding site IVa [ion binding]; other site
1118963002435	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1118963002436	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1118963002437	putative active site [active]
1118963002438	putative metal binding site [ion binding]; other site
1118963002439	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1118963002440	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1118963002441	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1118963002442	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1118963002443	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1118963002444	NAD(P) binding site [chemical binding]; other site
1118963002445	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1118963002446	carbon starvation protein A; Provisional; Region: PRK15015
1118963002447	Carbon starvation protein CstA; Region: CstA; pfam02554
1118963002448	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1118963002449	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1118963002450	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
1118963002451	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1118963002452	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963002453	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963002454	active site
1118963002455	catalytic tetrad [active]
1118963002456	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963002457	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1118963002458	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963002459	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963002460	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
1118963002461	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
1118963002462	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1118963002463	metal binding site [ion binding]; metal-binding site
1118963002464	putative dimer interface [polypeptide binding]; other site
1118963002465	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1118963002466	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1118963002467	tetramerization interface [polypeptide binding]; other site
1118963002468	NAD(P) binding site [chemical binding]; other site
1118963002469	catalytic residues [active]
1118963002470	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1118963002471	TPP-binding site [chemical binding]; other site
1118963002472	dimer interface [polypeptide binding]; other site
1118963002473	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1118963002474	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1118963002475	PYR/PP interface [polypeptide binding]; other site
1118963002476	dimer interface [polypeptide binding]; other site
1118963002477	TPP binding site [chemical binding]; other site
1118963002478	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1118963002479	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1118963002480	putative substrate binding site [chemical binding]; other site
1118963002481	putative ATP binding site [chemical binding]; other site
1118963002482	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1118963002483	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
1118963002484	NAD(P) binding site [chemical binding]; other site
1118963002485	active site
1118963002486	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963002487	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963002488	NAD(P) binding site [chemical binding]; other site
1118963002489	active site
1118963002490	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1118963002491	short chain dehydrogenase; Provisional; Region: PRK06523
1118963002492	classical (c) SDRs; Region: SDR_c; cd05233
1118963002493	NAD(P) binding site [chemical binding]; other site
1118963002494	active site
1118963002495	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963002496	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963002497	NAD(P) binding site [chemical binding]; other site
1118963002498	active site
1118963002499	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963002500	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963002501	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1118963002502	dimerization interface [polypeptide binding]; other site
1118963002503	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963002504	NifU-like domain; Region: NifU; cl00484
1118963002505	short chain dehydrogenase; Provisional; Region: PRK06114
1118963002506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963002507	NAD(P) binding site [chemical binding]; other site
1118963002508	active site
1118963002509	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1118963002510	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1118963002511	ligand binding site [chemical binding]; other site
1118963002512	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1118963002513	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1118963002514	Walker A/P-loop; other site
1118963002515	ATP binding site [chemical binding]; other site
1118963002516	Q-loop/lid; other site
1118963002517	ABC transporter signature motif; other site
1118963002518	Walker B; other site
1118963002519	D-loop; other site
1118963002520	H-loop/switch region; other site
1118963002521	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1118963002522	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1118963002523	TM-ABC transporter signature motif; other site
1118963002524	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1118963002525	classical (c) SDRs; Region: SDR_c; cd05233
1118963002526	NAD(P) binding site [chemical binding]; other site
1118963002527	active site
1118963002528	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963002529	classical (c) SDRs; Region: SDR_c; cd05233
1118963002530	NAD(P) binding site [chemical binding]; other site
1118963002531	active site
1118963002532	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
1118963002533	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1118963002534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963002535	putative substrate translocation pore; other site
1118963002536	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963002537	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963002538	GAF domain; Region: GAF; pfam01590
1118963002539	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1118963002540	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1118963002541	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1118963002542	potential catalytic triad [active]
1118963002543	conserved cys residue [active]
1118963002544	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963002545	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963002546	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1118963002547	dimerization interface [polypeptide binding]; other site
1118963002548	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1118963002549	phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351
1118963002550	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963002551	motif II; other site
1118963002552	TAP-like protein; Region: Abhydrolase_4; pfam08386
1118963002553	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963002554	DNA polymerase III subunit delta'; Validated; Region: PRK07940
1118963002555	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1118963002556	thymidylate kinase; Validated; Region: tmk; PRK00698
1118963002557	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1118963002558	TMP-binding site; other site
1118963002559	ATP-binding site [chemical binding]; other site
1118963002560	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1118963002561	homodimer interface [polypeptide binding]; other site
1118963002562	substrate-cofactor binding pocket; other site
1118963002563	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963002564	catalytic residue [active]
1118963002565	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
1118963002566	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1118963002567	catalytic core [active]
1118963002568	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1118963002569	PhoU domain; Region: PhoU; pfam01895
1118963002570	PhoU domain; Region: PhoU; pfam01895
1118963002571	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1118963002572	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1118963002573	dimer interface [polypeptide binding]; other site
1118963002574	phosphorylation site [posttranslational modification]
1118963002575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963002576	ATP binding site [chemical binding]; other site
1118963002577	Mg2+ binding site [ion binding]; other site
1118963002578	G-X-G motif; other site
1118963002579	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1118963002580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963002581	active site
1118963002582	phosphorylation site [posttranslational modification]
1118963002583	intermolecular recognition site; other site
1118963002584	dimerization interface [polypeptide binding]; other site
1118963002585	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1118963002586	DNA binding site [nucleotide binding]
1118963002587	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
1118963002588	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1118963002589	substrate binding site; other site
1118963002590	dimer interface; other site
1118963002591	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1118963002592	homotrimer interaction site [polypeptide binding]; other site
1118963002593	zinc binding site [ion binding]; other site
1118963002594	CDP-binding sites; other site
1118963002595	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1118963002596	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1118963002597	active site
1118963002598	HIGH motif; other site
1118963002599	KMSKS motif; other site
1118963002600	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1118963002601	tRNA binding surface [nucleotide binding]; other site
1118963002602	anticodon binding site; other site
1118963002603	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1118963002604	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1118963002605	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1118963002606	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1118963002607	putative active site [active]
1118963002608	catalytic triad [active]
1118963002609	putative dimer interface [polypeptide binding]; other site
1118963002610	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1118963002611	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1118963002612	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1118963002613	active site
1118963002614	catalytic site [active]
1118963002615	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
1118963002616	active site
1118963002617	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
1118963002618	RNAase interaction site [polypeptide binding]; other site
1118963002619	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1118963002620	putative homodimer interface [polypeptide binding]; other site
1118963002621	putative active site pocket [active]
1118963002622	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1118963002623	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1118963002624	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
1118963002625	Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
1118963002626	active site
1118963002627	homodimer interface [polypeptide binding]; other site
1118963002628	catalytic site [active]
1118963002629	acceptor binding site [chemical binding]; other site
1118963002630	trehalose synthase; Region: treS_nterm; TIGR02456
1118963002631	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1118963002632	active site
1118963002633	catalytic site [active]
1118963002634	glycogen branching enzyme; Provisional; Region: PRK14705
1118963002635	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl19286
1118963002636	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1118963002637	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1118963002638	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1118963002639	active site
1118963002640	catalytic site [active]
1118963002641	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1118963002642	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1118963002643	hydrophobic ligand binding site; other site
1118963002644	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1118963002645	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963002646	Coenzyme A binding pocket [chemical binding]; other site
1118963002647	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1118963002648	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
1118963002649	active site
1118963002650	catalytic site [active]
1118963002651	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1118963002652	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1118963002653	maltose transporter membrane protein; Provisional; Region: malF; PRK10999
1118963002654	Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785
1118963002655	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963002656	dimer interface [polypeptide binding]; other site
1118963002657	conserved gate region; other site
1118963002658	putative PBP binding loops; other site
1118963002659	ABC-ATPase subunit interface; other site
1118963002660	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963002661	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963002662	dimer interface [polypeptide binding]; other site
1118963002663	conserved gate region; other site
1118963002664	putative PBP binding loops; other site
1118963002665	ABC-ATPase subunit interface; other site
1118963002666	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1118963002667	homodimer interface [polypeptide binding]; other site
1118963002668	maltodextrin glucosidase; Provisional; Region: PRK10785
1118963002669	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1118963002670	active site
1118963002671	homodimer interface [polypeptide binding]; other site
1118963002672	catalytic site [active]
1118963002673	FAD binding domain; Region: FAD_binding_4; pfam01565
1118963002674	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1118963002675	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
1118963002676	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1118963002677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963002678	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1118963002679	cytosine deaminase; Provisional; Region: PRK05985
1118963002680	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963002681	active site
1118963002682	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1118963002683	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963002684	DNA-binding site [nucleotide binding]; DNA binding site
1118963002685	FCD domain; Region: FCD; pfam07729
1118963002686	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
1118963002687	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
1118963002688	A subgroup of  the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568
1118963002689	active site
1118963002690	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1118963002691	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1118963002692	Walker A/P-loop; other site
1118963002693	ATP binding site [chemical binding]; other site
1118963002694	Q-loop/lid; other site
1118963002695	ABC transporter signature motif; other site
1118963002696	Walker B; other site
1118963002697	D-loop; other site
1118963002698	H-loop/switch region; other site
1118963002699	TOBE domain; Region: TOBE_2; pfam08402
1118963002700	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1118963002701	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
1118963002702	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1118963002703	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1118963002704	active site
1118963002705	homotetramer interface [polypeptide binding]; other site
1118963002706	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1118963002707	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1118963002708	catalytic residues [active]
1118963002709	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1118963002710	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1118963002711	putative Zn2+ binding site [ion binding]; other site
1118963002712	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
1118963002713	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1118963002714	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1118963002715	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
1118963002716	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1118963002717	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963002718	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963002719	DNA binding site [nucleotide binding]
1118963002720	domain linker motif; other site
1118963002721	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
1118963002722	putative ligand binding site [chemical binding]; other site
1118963002723	putative dimerization interface [polypeptide binding]; other site
1118963002724	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963002725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963002726	dimer interface [polypeptide binding]; other site
1118963002727	conserved gate region; other site
1118963002728	putative PBP binding loops; other site
1118963002729	ABC-ATPase subunit interface; other site
1118963002730	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963002731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963002732	dimer interface [polypeptide binding]; other site
1118963002733	conserved gate region; other site
1118963002734	putative PBP binding loops; other site
1118963002735	ABC-ATPase subunit interface; other site
1118963002736	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963002737	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963002738	Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995
1118963002739	active site
1118963002740	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1118963002741	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1118963002742	substrate binding [chemical binding]; other site
1118963002743	active site
1118963002744	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1118963002745	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
1118963002746	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1118963002747	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963002748	ATP binding site [chemical binding]; other site
1118963002749	putative Mg++ binding site [ion binding]; other site
1118963002750	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963002751	nucleotide binding region [chemical binding]; other site
1118963002752	ATP-binding site [chemical binding]; other site
1118963002753	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1118963002754	putative substrate binding site [chemical binding]; other site
1118963002755	putative ATP binding site [chemical binding]; other site
1118963002756	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1118963002757	catalytic core [active]
1118963002758	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1118963002759	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963002760	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963002761	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
1118963002762	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
1118963002763	Protein of unknown function DUF72; Region: DUF72; pfam01904
1118963002764	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963002765	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963002766	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963002767	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963002768	NAD(P) binding site [chemical binding]; other site
1118963002769	active site
1118963002770	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
1118963002771	active site
1118963002772	acyl-coenzyme A oxidase; Region: PLN02526
1118963002773	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1118963002774	active site
1118963002775	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1118963002776	putative active site [active]
1118963002777	putative catalytic site [active]
1118963002778	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963002779	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963002780	putative substrate translocation pore; other site
1118963002781	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1118963002782	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1118963002783	acyl-activating enzyme (AAE) consensus motif; other site
1118963002784	putative AMP binding site [chemical binding]; other site
1118963002785	putative active site [active]
1118963002786	putative CoA binding site [chemical binding]; other site
1118963002787	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1118963002788	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1118963002789	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1118963002790	CAAX protease self-immunity; Region: Abi; pfam02517
1118963002791	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1118963002792	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963002793	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
1118963002794	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1118963002795	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963002796	active site
1118963002797	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1118963002798	active site
1118963002799	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1118963002800	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963002801	non-specific DNA binding site [nucleotide binding]; other site
1118963002802	salt bridge; other site
1118963002803	sequence-specific DNA binding site [nucleotide binding]; other site
1118963002804	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1118963002805	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963002806	non-specific DNA binding site [nucleotide binding]; other site
1118963002807	salt bridge; other site
1118963002808	sequence-specific DNA binding site [nucleotide binding]; other site
1118963002809	Cupin domain; Region: Cupin_2; pfam07883
1118963002810	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1118963002811	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1118963002812	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
1118963002813	metal binding site [ion binding]; metal-binding site
1118963002814	putative dimer interface [polypeptide binding]; other site
1118963002815	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
1118963002816	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1118963002817	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963002818	putative substrate translocation pore; other site
1118963002819	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963002820	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963002821	glycine dehydrogenase; Provisional; Region: PRK05367
1118963002822	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1118963002823	tetramer interface [polypeptide binding]; other site
1118963002824	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963002825	catalytic residue [active]
1118963002826	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
1118963002827	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963002828	catalytic residue [active]
1118963002829	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1118963002830	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1118963002831	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1118963002832	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1118963002833	lipoyl attachment site [posttranslational modification]; other site
1118963002834	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1118963002835	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1118963002836	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1118963002837	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1118963002838	active site
1118963002839	substrate binding site [chemical binding]; other site
1118963002840	Mg2+ binding site [ion binding]; other site
1118963002841	FemAB family; Region: FemAB; pfam02388
1118963002842	FemAB family; Region: FemAB; pfam02388
1118963002843	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1118963002844	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1118963002845	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
1118963002846	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1118963002847	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1118963002848	FAD binding pocket [chemical binding]; other site
1118963002849	FAD binding motif [chemical binding]; other site
1118963002850	phosphate binding motif [ion binding]; other site
1118963002851	NAD binding pocket [chemical binding]; other site
1118963002852	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1118963002853	ligand binding site [chemical binding]; other site
1118963002854	active site
1118963002855	UGI interface [polypeptide binding]; other site
1118963002856	catalytic site [active]
1118963002857	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
1118963002858	Merozoite surface antigen 2c; Region: MSA-2c; pfam12238
1118963002859	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1118963002860	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1118963002861	DNA-binding site [nucleotide binding]; DNA binding site
1118963002862	RNA-binding motif; other site
1118963002863	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
1118963002864	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1118963002865	ring oligomerisation interface [polypeptide binding]; other site
1118963002866	ATP/Mg binding site [chemical binding]; other site
1118963002867	stacking interactions; other site
1118963002868	hinge regions; other site
1118963002869	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1118963002870	RNA/DNA hybrid binding site [nucleotide binding]; other site
1118963002871	active site
1118963002872	Domain of unknown function (DUF4440); Region: DUF4440; pfam14534
1118963002873	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1118963002874	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1118963002875	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1118963002876	dimerization interface [polypeptide binding]; other site
1118963002877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1118963002878	dimer interface [polypeptide binding]; other site
1118963002879	phosphorylation site [posttranslational modification]
1118963002880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963002881	ATP binding site [chemical binding]; other site
1118963002882	Mg2+ binding site [ion binding]; other site
1118963002883	G-X-G motif; other site
1118963002884	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1118963002885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963002886	active site
1118963002887	phosphorylation site [posttranslational modification]
1118963002888	intermolecular recognition site; other site
1118963002889	dimerization interface [polypeptide binding]; other site
1118963002890	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1118963002891	DNA binding site [nucleotide binding]
1118963002892	Lysine efflux permease [General function prediction only]; Region: COG1279
1118963002893	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1118963002894	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963002895	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963002896	dimerization interface [polypeptide binding]; other site
1118963002897	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1118963002898	Cupredoxin domain 1 of laccase-like multicopper oxidases; including laccase, CueO, spore coat protein A, ascorbate oxidase and similar proteins; Region: CuRO_1_LCC_like; cd04206
1118963002899	Domain 2 interface [polypeptide binding]; other site
1118963002900	Domain 3 interface [polypeptide binding]; other site
1118963002901	trinuclear Cu binding site [ion binding]; other site
1118963002902	Cupredoxin superfamily; Region: Cupredoxin; cl19115
1118963002903	The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202
1118963002904	trimer interface [polypeptide binding]; other site
1118963002905	trinuclear Cu binding site [ion binding]; other site
1118963002906	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1118963002907	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1118963002908	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963002909	ATP binding site [chemical binding]; other site
1118963002910	putative Mg++ binding site [ion binding]; other site
1118963002911	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963002912	nucleotide binding region [chemical binding]; other site
1118963002913	ATP-binding site [chemical binding]; other site
1118963002914	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1118963002915	WYL domain; Region: WYL; cl14852
1118963002916	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
1118963002917	H+ Antiporter protein; Region: 2A0121; TIGR00900
1118963002918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963002919	putative substrate translocation pore; other site
1118963002920	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
1118963002921	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963002922	catalytic residue [active]
1118963002923	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1118963002924	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1118963002925	Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
1118963002926	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1118963002927	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1118963002928	Peptidase family M23; Region: Peptidase_M23; pfam01551
1118963002929	NlpC/P60 family; Region: NLPC_P60; cl17555
1118963002930	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963002931	active site
1118963002932	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1118963002933	active site
1118963002934	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1118963002935	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1118963002936	dimer interface [polypeptide binding]; other site
1118963002937	putative functional site; other site
1118963002938	putative MPT binding site; other site
1118963002939	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1118963002940	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1118963002941	putative molybdopterin cofactor binding site [chemical binding]; other site
1118963002942	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1118963002943	putative molybdopterin cofactor binding site; other site
1118963002944	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1118963002945	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
1118963002946	alpha-mannosidase; Provisional; Region: PRK09819
1118963002947	active site
1118963002948	catalytic site [active]
1118963002949	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
1118963002950	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
1118963002951	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1118963002952	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1118963002953	Walker A/P-loop; other site
1118963002954	ATP binding site [chemical binding]; other site
1118963002955	Q-loop/lid; other site
1118963002956	ABC transporter signature motif; other site
1118963002957	Walker B; other site
1118963002958	D-loop; other site
1118963002959	H-loop/switch region; other site
1118963002960	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1118963002961	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963002962	dimer interface [polypeptide binding]; other site
1118963002963	conserved gate region; other site
1118963002964	putative PBP binding loops; other site
1118963002965	ABC-ATPase subunit interface; other site
1118963002966	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1118963002967	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1118963002968	substrate binding pocket [chemical binding]; other site
1118963002969	membrane-bound complex binding site; other site
1118963002970	hinge residues; other site
1118963002971	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1118963002972	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963002973	ABC transporter; Region: ABC_tran_2; pfam12848
1118963002974	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963002975	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1118963002976	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1118963002977	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963002978	Walker A/P-loop; other site
1118963002979	ATP binding site [chemical binding]; other site
1118963002980	Q-loop/lid; other site
1118963002981	ABC transporter signature motif; other site
1118963002982	Walker B; other site
1118963002983	D-loop; other site
1118963002984	H-loop/switch region; other site
1118963002985	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1118963002986	nudix motif; other site
1118963002987	Protein of unknown function (DUF998); Region: DUF998; pfam06197
1118963002988	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1118963002989	active site
1118963002990	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1118963002991	Part of AAA domain; Region: AAA_19; pfam13245
1118963002992	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
1118963002993	Predicted membrane-bound mannosyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG4745
1118963002994	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1118963002995	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1118963002996	CoA-ligase; Region: Ligase_CoA; pfam00549
1118963002997	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1118963002998	CoA binding domain; Region: CoA_binding; smart00881
1118963002999	CoA binding domain; Region: CoA_binding; cl17356
1118963003000	CoA-ligase; Region: Ligase_CoA; pfam00549
1118963003001	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1118963003002	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1118963003003	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1118963003004	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
1118963003005	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
1118963003006	Fn3 associated; Region: Fn3_assoc; pfam13287
1118963003007	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963003008	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963003009	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963003010	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963003011	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963003012	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1118963003013	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1118963003014	catalytic triad [active]
1118963003015	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
1118963003016	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1118963003017	fragilysin; Region: fragilysin; TIGR03935
1118963003018	active site
1118963003019	fragilysin; Region: fragilysin; TIGR03935
1118963003020	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1118963003021	dinuclear metal binding motif [ion binding]; other site
1118963003022	CCC1-related family of proteins; Region: CCC1_like; cl00278
1118963003023	hypothetical protein; Provisional; Region: PRK06851
1118963003024	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479
1118963003025	Na binding site [ion binding]; other site
1118963003026	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1118963003027	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963003028	non-specific DNA binding site [nucleotide binding]; other site
1118963003029	salt bridge; other site
1118963003030	sequence-specific DNA binding site [nucleotide binding]; other site
1118963003031	Cupin domain; Region: Cupin_2; pfam07883
1118963003032	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1118963003033	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1118963003034	putative active site [active]
1118963003035	Amino acid permease; Region: AA_permease_2; pfam13520
1118963003036	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1118963003037	oligomer interface [polypeptide binding]; other site
1118963003038	putative active site [active]
1118963003039	Mn binding site [ion binding]; other site
1118963003040	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1118963003041	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1118963003042	PYR/PP interface [polypeptide binding]; other site
1118963003043	dimer interface [polypeptide binding]; other site
1118963003044	TPP binding site [chemical binding]; other site
1118963003045	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1118963003046	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1118963003047	TPP-binding site [chemical binding]; other site
1118963003048	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963003049	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963003050	putative DNA binding site [nucleotide binding]; other site
1118963003051	putative Zn2+ binding site [ion binding]; other site
1118963003052	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1118963003053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963003054	putative substrate translocation pore; other site
1118963003055	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
1118963003056	Protein of unknown function (DUF2664); Region: DUF2664; pfam10867
1118963003057	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1118963003058	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1118963003059	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963003060	Walker A/P-loop; other site
1118963003061	ATP binding site [chemical binding]; other site
1118963003062	Q-loop/lid; other site
1118963003063	ABC transporter signature motif; other site
1118963003064	Walker B; other site
1118963003065	D-loop; other site
1118963003066	H-loop/switch region; other site
1118963003067	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1118963003068	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1118963003069	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1118963003070	Walker A/P-loop; other site
1118963003071	ATP binding site [chemical binding]; other site
1118963003072	Q-loop/lid; other site
1118963003073	ABC transporter signature motif; other site
1118963003074	Walker B; other site
1118963003075	D-loop; other site
1118963003076	H-loop/switch region; other site
1118963003077	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1118963003078	active site
1118963003079	Class I aldolases; Region: Aldolase_Class_I; cd00945
1118963003080	catalytic residue [active]
1118963003081	Replication initiator protein A; Region: RPA; cl19398
1118963003082	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
1118963003083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963003084	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1118963003085	Walker A motif; other site
1118963003086	ATP binding site [chemical binding]; other site
1118963003087	Walker B motif; other site
1118963003088	arginine finger; other site
1118963003089	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
1118963003090	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1118963003091	PAS fold; Region: PAS_4; pfam08448
1118963003092	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1118963003093	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1118963003094	dimer interface [polypeptide binding]; other site
1118963003095	phosphorylation site [posttranslational modification]
1118963003096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963003097	ATP binding site [chemical binding]; other site
1118963003098	Mg2+ binding site [ion binding]; other site
1118963003099	G-X-G motif; other site
1118963003100	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1118963003101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963003102	active site
1118963003103	phosphorylation site [posttranslational modification]
1118963003104	intermolecular recognition site; other site
1118963003105	dimerization interface [polypeptide binding]; other site
1118963003106	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1118963003107	DNA binding site [nucleotide binding]
1118963003108	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
1118963003109	Ferredoxin [Energy production and conversion]; Region: COG1146
1118963003110	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1118963003111	NAD(P) binding site [chemical binding]; other site
1118963003112	catalytic residues [active]
1118963003113	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1118963003114	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1118963003115	putative NAD(P) binding site [chemical binding]; other site
1118963003116	putative active site [active]
1118963003117	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1118963003118	inhibitor site; inhibition site
1118963003119	active site
1118963003120	dimer interface [polypeptide binding]; other site
1118963003121	catalytic residue [active]
1118963003122	enoyl-CoA hydratase; Provisional; Region: PRK06494
1118963003123	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1118963003124	substrate binding site [chemical binding]; other site
1118963003125	oxyanion hole (OAH) forming residues; other site
1118963003126	trimer interface [polypeptide binding]; other site
1118963003127	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1118963003128	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1118963003129	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963003130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963003131	putative substrate translocation pore; other site
1118963003132	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1118963003133	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963003134	non-specific DNA binding site [nucleotide binding]; other site
1118963003135	salt bridge; other site
1118963003136	sequence-specific DNA binding site [nucleotide binding]; other site
1118963003137	Cupin domain; Region: Cupin_2; pfam07883
1118963003138	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
1118963003139	additional DNA contacts [nucleotide binding]; other site
1118963003140	mismatch recognition site; other site
1118963003141	active site
1118963003142	zinc binding site [ion binding]; other site
1118963003143	DNA intercalation site [nucleotide binding]; other site
1118963003144	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1118963003145	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1118963003146	AAA domain; Region: AAA_26; pfam13500
1118963003147	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1118963003148	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
1118963003149	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963003150	catalytic residue [active]
1118963003151	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1118963003152	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1118963003153	inhibitor-cofactor binding pocket; inhibition site
1118963003154	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963003155	catalytic residue [active]
1118963003156	biotin synthase; Validated; Region: PRK06256
1118963003157	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1118963003158	FeS/SAM binding site; other site
1118963003159	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1118963003160	Na binding site [ion binding]; other site
1118963003161	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1118963003162	CsbD-like; Region: CsbD; pfam05532
1118963003163	oxidoreductase; Provisional; Region: PRK06128
1118963003164	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1118963003165	NAD binding site [chemical binding]; other site
1118963003166	metal binding site [ion binding]; metal-binding site
1118963003167	active site
1118963003168	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1118963003169	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1118963003170	NAD binding site [chemical binding]; other site
1118963003171	catalytic Zn binding site [ion binding]; other site
1118963003172	structural Zn binding site [ion binding]; other site
1118963003173	transcription termination factor Rho; Provisional; Region: PRK12678
1118963003174	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1118963003175	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1118963003176	FMN binding site [chemical binding]; other site
1118963003177	active site
1118963003178	substrate binding site [chemical binding]; other site
1118963003179	catalytic residue [active]
1118963003180	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1118963003181	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963003182	DNA-binding site [nucleotide binding]; DNA binding site
1118963003183	FCD domain; Region: FCD; pfam07729
1118963003184	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963003185	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963003186	dihydroxyacetone kinase; Provisional; Region: PRK14479
1118963003187	Dak1 domain; Region: Dak1; cl10557
1118963003188	DAK2 domain; Region: Dak2; pfam02734
1118963003189	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
1118963003190	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1118963003191	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1118963003192	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1118963003193	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1118963003194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963003195	NAD(P) binding site [chemical binding]; other site
1118963003196	active site
1118963003197	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1118963003198	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963003199	putative substrate translocation pore; other site
1118963003200	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1118963003201	substrate binding site [chemical binding]; other site
1118963003202	dimer interface [polypeptide binding]; other site
1118963003203	catalytic triad [active]
1118963003204	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
1118963003205	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
1118963003206	RNase_H superfamily; Region: RNase_H_2; pfam13482
1118963003207	AAA domain; Region: AAA_30; pfam13604
1118963003208	AAA domain; Region: AAA_11; pfam13086
1118963003209	AAA domain; Region: AAA_12; pfam13087
1118963003210	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1118963003211	nucleoside/Zn binding site; other site
1118963003212	dimer interface [polypeptide binding]; other site
1118963003213	catalytic motif [active]
1118963003214	single-stranded DNA-binding protein; Region: PHA00458
1118963003215	FOG: CBS domain [General function prediction only]; Region: COG0517
1118963003216	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1118963003217	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
1118963003218	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1118963003219	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1118963003220	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1118963003221	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1118963003222	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1118963003223	RNA binding site [nucleotide binding]; other site
1118963003224	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1118963003225	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1118963003226	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
1118963003227	cell division protein FtsN; Region: ftsN; TIGR02223
1118963003228	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1118963003229	active site
1118963003230	purine riboside binding site [chemical binding]; other site
1118963003231	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
1118963003232	acylphosphatase; Provisional; Region: PRK14427
1118963003233	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963003234	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963003235	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963003236	Male sterility protein; Region: NAD_binding_4; pfam07993
1118963003237	NAD(P) binding site [chemical binding]; other site
1118963003238	active site
1118963003239	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1118963003240	substrate binding site [chemical binding]; other site
1118963003241	dimer interface [polypeptide binding]; other site
1118963003242	ATP binding site [chemical binding]; other site
1118963003243	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1118963003244	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1118963003245	DNA-binding site [nucleotide binding]; DNA binding site
1118963003246	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1118963003247	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1118963003248	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963003249	putative substrate translocation pore; other site
1118963003250	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
1118963003251	active site
1118963003252	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963003253	dimerization interface [polypeptide binding]; other site
1118963003254	putative DNA binding site [nucleotide binding]; other site
1118963003255	putative Zn2+ binding site [ion binding]; other site
1118963003256	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
1118963003257	putative hydrophobic ligand binding site [chemical binding]; other site
1118963003258	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1118963003259	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1118963003260	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1118963003261	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1118963003262	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963003263	dimer interface [polypeptide binding]; other site
1118963003264	conserved gate region; other site
1118963003265	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1118963003266	ABC-ATPase subunit interface; other site
1118963003267	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963003268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963003269	dimer interface [polypeptide binding]; other site
1118963003270	ABC-ATPase subunit interface; other site
1118963003271	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963003272	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963003273	Protein of unknown function, DUF624; Region: DUF624; pfam04854
1118963003274	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963003275	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1118963003276	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963003277	active site
1118963003278	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1118963003279	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963003280	active site
1118963003281	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1118963003282	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
1118963003283	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1118963003284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1118963003285	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
1118963003286	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1118963003287	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1118963003288	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1118963003289	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963003290	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963003291	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963003292	Methane oxygenase PmoA; Region: PmoA; pfam14100
1118963003293	Cupin domain; Region: Cupin_2; pfam07883
1118963003294	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963003295	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963003296	DNA binding site [nucleotide binding]
1118963003297	domain linker motif; other site
1118963003298	Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296
1118963003299	putative dimerization interface [polypeptide binding]; other site
1118963003300	putative ligand binding site [chemical binding]; other site
1118963003301	GAF domain; Region: GAF_2; pfam13185
1118963003302	ANTAR domain; Region: ANTAR; pfam03861
1118963003303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963003304	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963003305	putative substrate translocation pore; other site
1118963003306	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963003307	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1118963003308	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1118963003309	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1118963003310	putative NAD(P) binding site [chemical binding]; other site
1118963003311	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963003312	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1118963003313	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963003314	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963003315	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1118963003316	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
1118963003317	PLD-like domain; Region: PLDc_2; pfam13091
1118963003318	putative homodimer interface [polypeptide binding]; other site
1118963003319	putative active site [active]
1118963003320	catalytic site [active]
1118963003321	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1118963003322	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963003323	ATP binding site [chemical binding]; other site
1118963003324	putative Mg++ binding site [ion binding]; other site
1118963003325	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963003326	nucleotide binding region [chemical binding]; other site
1118963003327	ATP-binding site [chemical binding]; other site
1118963003328	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1118963003329	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963003330	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963003331	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1118963003332	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963003333	NAD(P) binding site [chemical binding]; other site
1118963003334	active site
1118963003335	TfoX N-terminal domain; Region: TfoX_N; cl17592
1118963003336	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1118963003337	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963003338	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1118963003339	DNA-binding site [nucleotide binding]; DNA binding site
1118963003340	RNA-binding motif; other site
1118963003341	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1118963003342	AAA ATPase domain; Region: AAA_16; pfam13191
1118963003343	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1118963003344	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963003345	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963003346	DNA binding residues [nucleotide binding]
1118963003347	dimerization interface [polypeptide binding]; other site
1118963003348	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963003349	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963003350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963003351	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963003352	putative substrate translocation pore; other site
1118963003353	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1118963003354	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963003355	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1118963003356	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
1118963003357	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1118963003358	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1118963003359	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1118963003360	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1118963003361	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1118963003362	Excalibur calcium-binding domain; Region: Excalibur; smart00894
1118963003363	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1118963003364	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1118963003365	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1118963003366	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1118963003367	DNA binding residues [nucleotide binding]
1118963003368	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1118963003369	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1118963003370	putative dimer interface [polypeptide binding]; other site
1118963003371	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1118963003372	putative dimer interface [polypeptide binding]; other site
1118963003373	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1118963003374	putative dimer interface [polypeptide binding]; other site
1118963003375	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
1118963003376	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1118963003377	active site
1118963003378	substrate binding site [chemical binding]; other site
1118963003379	cosubstrate binding site; other site
1118963003380	catalytic site [active]
1118963003381	benzoate transport; Region: 2A0115; TIGR00895
1118963003382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963003383	putative substrate translocation pore; other site
1118963003384	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
1118963003385	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1118963003386	putative active site [active]
1118963003387	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1118963003388	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1118963003389	putative active site [active]
1118963003390	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1118963003391	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1118963003392	purine monophosphate binding site [chemical binding]; other site
1118963003393	dimer interface [polypeptide binding]; other site
1118963003394	putative catalytic residues [active]
1118963003395	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1118963003396	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1118963003397	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1118963003398	catalytic triad [active]
1118963003399	conserved cis-peptide bond; other site
1118963003400	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1118963003401	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1118963003402	conserved cys residue [active]
1118963003403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963003404	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963003405	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1118963003406	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963003407	FAD dependent oxidoreductase; Region: DAO; pfam01266
1118963003408	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1118963003409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963003410	dimer interface [polypeptide binding]; other site
1118963003411	conserved gate region; other site
1118963003412	putative PBP binding loops; other site
1118963003413	ABC-ATPase subunit interface; other site
1118963003414	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1118963003415	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1118963003416	Walker A/P-loop; other site
1118963003417	ATP binding site [chemical binding]; other site
1118963003418	Q-loop/lid; other site
1118963003419	ABC transporter signature motif; other site
1118963003420	Walker B; other site
1118963003421	D-loop; other site
1118963003422	H-loop/switch region; other site
1118963003423	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1118963003424	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1118963003425	substrate binding pocket [chemical binding]; other site
1118963003426	membrane-bound complex binding site; other site
1118963003427	hinge residues; other site
1118963003428	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
1118963003429	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963003430	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1118963003431	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963003432	DNA-binding site [nucleotide binding]; DNA binding site
1118963003433	UTRA domain; Region: UTRA; pfam07702
1118963003434	phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351
1118963003435	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963003436	motif II; other site
1118963003437	Predicted membrane protein [Function unknown]; Region: COG2259
1118963003438	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963003439	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963003440	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963003441	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1118963003442	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1118963003443	Walker A/P-loop; other site
1118963003444	ATP binding site [chemical binding]; other site
1118963003445	Q-loop/lid; other site
1118963003446	ABC transporter signature motif; other site
1118963003447	Walker B; other site
1118963003448	D-loop; other site
1118963003449	H-loop/switch region; other site
1118963003450	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1118963003451	FtsX-like permease family; Region: FtsX; pfam02687
1118963003452	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1118963003453	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1118963003454	putative ligand binding site [chemical binding]; other site
1118963003455	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1118963003456	TM-ABC transporter signature motif; other site
1118963003457	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1118963003458	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1118963003459	Walker A/P-loop; other site
1118963003460	ATP binding site [chemical binding]; other site
1118963003461	Q-loop/lid; other site
1118963003462	ABC transporter signature motif; other site
1118963003463	Walker B; other site
1118963003464	D-loop; other site
1118963003465	H-loop/switch region; other site
1118963003466	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1118963003467	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963003468	dimerization interface [polypeptide binding]; other site
1118963003469	putative DNA binding site [nucleotide binding]; other site
1118963003470	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963003471	putative Zn2+ binding site [ion binding]; other site
1118963003472	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963003473	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1118963003474	nucleotide binding site [chemical binding]; other site
1118963003475	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963003476	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
1118963003477	putative active site [active]
1118963003478	catalytic triad [active]
1118963003479	putative dimer interface [polypeptide binding]; other site
1118963003480	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1118963003481	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
1118963003482	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1118963003483	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1118963003484	alanine racemase; Reviewed; Region: alr; PRK00053
1118963003485	active site
1118963003486	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1118963003487	dimer interface [polypeptide binding]; other site
1118963003488	substrate binding site [chemical binding]; other site
1118963003489	catalytic residues [active]
1118963003490	amino acid transporter; Region: 2A0306; TIGR00909
1118963003491	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963003492	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1118963003493	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1118963003494	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
1118963003495	Predicted transcriptional regulators [Transcription]; Region: COG1695
1118963003496	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1118963003497	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1118963003498	trimer interface [polypeptide binding]; other site
1118963003499	putative metal binding site [ion binding]; other site
1118963003500	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963003501	S-adenosylmethionine binding site [chemical binding]; other site
1118963003502	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1118963003503	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1118963003504	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1118963003505	putative active site [active]
1118963003506	putative substrate binding site [chemical binding]; other site
1118963003507	putative cosubstrate binding site; other site
1118963003508	catalytic site [active]
1118963003509	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1118963003510	dimer interface [polypeptide binding]; other site
1118963003511	active site
1118963003512	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1118963003513	folate binding site [chemical binding]; other site
1118963003514	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
1118963003515	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1118963003516	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1118963003517	homodimer interface [polypeptide binding]; other site
1118963003518	NADP binding site [chemical binding]; other site
1118963003519	substrate binding site [chemical binding]; other site
1118963003520	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1118963003521	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963003522	Walker A/P-loop; other site
1118963003523	ATP binding site [chemical binding]; other site
1118963003524	Q-loop/lid; other site
1118963003525	ABC transporter signature motif; other site
1118963003526	Walker B; other site
1118963003527	D-loop; other site
1118963003528	H-loop/switch region; other site
1118963003529	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1118963003530	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1118963003531	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1118963003532	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1118963003533	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963003534	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963003535	putative substrate translocation pore; other site
1118963003536	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1118963003537	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963003538	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963003539	DNA binding site [nucleotide binding]
1118963003540	domain linker motif; other site
1118963003541	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1118963003542	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
1118963003543	putative active site [active]
1118963003544	putative catalytic site [active]
1118963003545	putative DNA binding site [nucleotide binding]; other site
1118963003546	putative phosphate binding site [ion binding]; other site
1118963003547	metal binding site A [ion binding]; metal-binding site
1118963003548	putative AP binding site [nucleotide binding]; other site
1118963003549	putative metal binding site B [ion binding]; other site
1118963003550	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
1118963003551	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1118963003552	active site
1118963003553	HIGH motif; other site
1118963003554	dimer interface [polypeptide binding]; other site
1118963003555	KMSKS motif; other site
1118963003556	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1118963003557	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1118963003558	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1118963003559	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1118963003560	Glycosyl hydrolase family 43; Region: GH43_2; cd08981
1118963003561	active site
1118963003562	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963003563	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963003564	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963003565	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1118963003566	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1118963003567	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1118963003568	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
1118963003569	L-aspartate oxidase; Provisional; Region: PRK06175
1118963003570	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1118963003571	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
1118963003572	putative Iron-sulfur protein interface [polypeptide binding]; other site
1118963003573	putative proximal heme binding site [chemical binding]; other site
1118963003574	putative SdhC-like subunit interface [polypeptide binding]; other site
1118963003575	putative distal heme binding site [chemical binding]; other site
1118963003576	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
1118963003577	putative Iron-sulfur protein interface [polypeptide binding]; other site
1118963003578	putative proximal heme binding site [chemical binding]; other site
1118963003579	putative SdhD-like interface [polypeptide binding]; other site
1118963003580	putative distal heme binding site [chemical binding]; other site
1118963003581	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
1118963003582	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1118963003583	active site
1118963003584	Cupin domain; Region: Cupin_2; cl17218
1118963003585	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1118963003586	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
1118963003587	metal binding site [ion binding]; metal-binding site
1118963003588	putative dimer interface [polypeptide binding]; other site
1118963003589	CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655
1118963003590	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963003591	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963003592	putative Zn2+ binding site [ion binding]; other site
1118963003593	putative DNA binding site [nucleotide binding]; other site
1118963003594	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1118963003595	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1118963003596	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1118963003597	NAD(P) binding site [chemical binding]; other site
1118963003598	substrate binding site [chemical binding]; other site
1118963003599	dimer interface [polypeptide binding]; other site
1118963003600	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1118963003601	ligand binding site [chemical binding]; other site
1118963003602	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1118963003603	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1118963003604	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1118963003605	Walker A/P-loop; other site
1118963003606	ATP binding site [chemical binding]; other site
1118963003607	Q-loop/lid; other site
1118963003608	ABC transporter signature motif; other site
1118963003609	Walker B; other site
1118963003610	D-loop; other site
1118963003611	H-loop/switch region; other site
1118963003612	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1118963003613	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1118963003614	TM-ABC transporter signature motif; other site
1118963003615	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1118963003616	TM-ABC transporter signature motif; other site
1118963003617	Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295
1118963003618	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1118963003619	active site
1118963003620	catalytic motif [active]
1118963003621	Zn binding site [ion binding]; other site
1118963003622	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1118963003623	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1118963003624	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1118963003625	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1118963003626	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1118963003627	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1118963003628	adenosine deaminase; Provisional; Region: PRK09358
1118963003629	active site
1118963003630	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1118963003631	homodimer interface [polypeptide binding]; other site
1118963003632	metal binding site [ion binding]; metal-binding site
1118963003633	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1118963003634	enolase; Provisional; Region: eno; PRK00077
1118963003635	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1118963003636	dimer interface [polypeptide binding]; other site
1118963003637	metal binding site [ion binding]; metal-binding site
1118963003638	substrate binding pocket [chemical binding]; other site
1118963003639	Septum formation initiator; Region: DivIC; pfam04977
1118963003640	Protein of unknown function (DUF501); Region: DUF501; pfam04417
1118963003641	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1118963003642	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483
1118963003643	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1118963003644	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1118963003645	active site
1118963003646	catalytic residues [active]
1118963003647	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1118963003648	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963003649	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
1118963003650	ACT domain; Region: ACT_3; pfam10000
1118963003651	ACT domain; Region: ACT_7; pfam13840
1118963003652	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963003653	Coenzyme A binding pocket [chemical binding]; other site
1118963003654	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1118963003655	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
1118963003656	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1118963003657	putative lipid kinase; Reviewed; Region: PRK13057
1118963003658	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1118963003659	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1118963003660	Walker A/P-loop; other site
1118963003661	ATP binding site [chemical binding]; other site
1118963003662	Q-loop/lid; other site
1118963003663	ABC transporter signature motif; other site
1118963003664	Walker B; other site
1118963003665	D-loop; other site
1118963003666	H-loop/switch region; other site
1118963003667	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1118963003668	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1118963003669	Walker A/P-loop; other site
1118963003670	ATP binding site [chemical binding]; other site
1118963003671	Q-loop/lid; other site
1118963003672	ABC transporter signature motif; other site
1118963003673	Walker B; other site
1118963003674	D-loop; other site
1118963003675	H-loop/switch region; other site
1118963003676	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1118963003677	TM-ABC transporter signature motif; other site
1118963003678	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1118963003679	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1118963003680	TM-ABC transporter signature motif; other site
1118963003681	Bax inhibitor 1 like; Region: BaxI_1; cl17691
1118963003682	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
1118963003683	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1118963003684	dimer interface [polypeptide binding]; other site
1118963003685	active site
1118963003686	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
1118963003687	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1118963003688	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1118963003689	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1118963003690	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
1118963003691	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1118963003692	nucleotide binding site/active site [active]
1118963003693	HIT family signature motif; other site
1118963003694	catalytic residue [active]
1118963003695	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
1118963003696	active site
1118963003697	catalytic residues [active]
1118963003698	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1118963003699	threonine dehydratase; Provisional; Region: PRK08198
1118963003700	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1118963003701	tetramer interface [polypeptide binding]; other site
1118963003702	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963003703	catalytic residue [active]
1118963003704	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
1118963003705	Rhomboid family; Region: Rhomboid; cl11446
1118963003706	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1118963003707	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1118963003708	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1118963003709	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
1118963003710	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1118963003711	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1118963003712	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
1118963003713	catalytic residues [active]
1118963003714	Haemolysin-III related; Region: HlyIII; cl03831
1118963003715	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
1118963003716	active site
1118963003717	dimer interface [polypeptide binding]; other site
1118963003718	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1118963003719	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1118963003720	putative active site [active]
1118963003721	PhoH-like protein; Region: PhoH; pfam02562
1118963003722	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1118963003723	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1118963003724	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1118963003725	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
1118963003726	nudix motif; other site
1118963003727	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1118963003728	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963003729	putative substrate translocation pore; other site
1118963003730	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1118963003731	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963003732	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1118963003733	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1118963003734	tetramer interface [polypeptide binding]; other site
1118963003735	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1118963003736	active site clefts [active]
1118963003737	zinc binding site [ion binding]; other site
1118963003738	dimer interface [polypeptide binding]; other site
1118963003739	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
1118963003740	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1118963003741	putative active site [active]
1118963003742	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151
1118963003743	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057
1118963003744	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1118963003745	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1118963003746	AIR carboxylase; Region: AIRC; pfam00731
1118963003747	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1118963003748	LabA_like proteins; Region: LabA_like/DUF88; cl10034
1118963003749	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1118963003750	GtrA-like protein; Region: GtrA; pfam04138
1118963003751	TIGR03089 family protein; Region: TIGR03089
1118963003752	Transcription factor WhiB; Region: Whib; pfam02467
1118963003753	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1118963003754	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1118963003755	active site
1118963003756	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1118963003757	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
1118963003758	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
1118963003759	Trm112p-like protein; Region: Trm112p; cl01066
1118963003760	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1118963003761	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1118963003762	homotetramer interface [polypeptide binding]; other site
1118963003763	ligand binding site [chemical binding]; other site
1118963003764	catalytic site [active]
1118963003765	NAD binding site [chemical binding]; other site
1118963003766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1118963003767	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1118963003768	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1118963003769	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1118963003770	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1118963003771	RDD family; Region: RDD; pfam06271
1118963003772	Integral membrane protein DUF95; Region: DUF95; pfam01944
1118963003773	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
1118963003774	Horizontally Transferred TransMembrane Domain; Region: HTTM; cl02773
1118963003775	antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034
1118963003776	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
1118963003777	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1118963003778	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1118963003779	acyl-activating enzyme (AAE) consensus motif; other site
1118963003780	putative AMP binding site [chemical binding]; other site
1118963003781	putative active site [active]
1118963003782	putative CoA binding site [chemical binding]; other site
1118963003783	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
1118963003784	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
1118963003785	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1118963003786	putative SAM binding site [chemical binding]; other site
1118963003787	putative homodimer interface [polypeptide binding]; other site
1118963003788	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1118963003789	tetramerization interface [polypeptide binding]; other site
1118963003790	NAD(P) binding site [chemical binding]; other site
1118963003791	catalytic residues [active]
1118963003792	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1118963003793	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1118963003794	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1118963003795	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1118963003796	Protein of unknown function DUF58; Region: DUF58; pfam01882
1118963003797	MoxR-like ATPases [General function prediction only]; Region: COG0714
1118963003798	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963003799	Walker A motif; other site
1118963003800	ATP binding site [chemical binding]; other site
1118963003801	Walker B motif; other site
1118963003802	arginine finger; other site
1118963003803	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1118963003804	active site
1118963003805	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1118963003806	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1118963003807	G5 domain; Region: G5; pfam07501
1118963003808	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1118963003809	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1118963003810	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
1118963003811	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1118963003812	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1118963003813	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1118963003814	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963003815	ABC transporter; Region: ABC_tran_2; pfam12848
1118963003816	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963003817	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1118963003818	dimer interface [polypeptide binding]; other site
1118963003819	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963003820	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963003821	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
1118963003822	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1118963003823	Substrate binding site; other site
1118963003824	Mg++ binding site; other site
1118963003825	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1118963003826	active site
1118963003827	substrate binding site [chemical binding]; other site
1118963003828	CoA binding site [chemical binding]; other site
1118963003829	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1118963003830	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
1118963003831	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1118963003832	active site
1118963003833	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1118963003834	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1118963003835	5S rRNA interface [nucleotide binding]; other site
1118963003836	CTC domain interface [polypeptide binding]; other site
1118963003837	L16 interface [polypeptide binding]; other site
1118963003838	Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693
1118963003839	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1118963003840	putative active site [active]
1118963003841	catalytic residue [active]
1118963003842	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963003843	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963003844	DNA binding residues [nucleotide binding]
1118963003845	dimerization interface [polypeptide binding]; other site
1118963003846	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963003847	Walker A motif; other site
1118963003848	ATP binding site [chemical binding]; other site
1118963003849	Walker B motif; other site
1118963003850	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963003851	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963003852	DNA binding residues [nucleotide binding]
1118963003853	AAA ATPase domain; Region: AAA_16; pfam13191
1118963003854	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1118963003855	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1118963003856	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963003857	catalytic residue [active]
1118963003858	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1118963003859	trimerization site [polypeptide binding]; other site
1118963003860	active site
1118963003861	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
1118963003862	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1118963003863	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1118963003864	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963003865	NAD(P) binding site [chemical binding]; other site
1118963003866	active site
1118963003867	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
1118963003868	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1118963003869	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1118963003870	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963003871	ATP binding site [chemical binding]; other site
1118963003872	putative Mg++ binding site [ion binding]; other site
1118963003873	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963003874	nucleotide binding region [chemical binding]; other site
1118963003875	ATP-binding site [chemical binding]; other site
1118963003876	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1118963003877	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1118963003878	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1118963003879	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1118963003880	intersubunit interface [polypeptide binding]; other site
1118963003881	active site
1118963003882	catalytic residue [active]
1118963003883	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1118963003884	RibD C-terminal domain; Region: RibD_C; cl17279
1118963003885	Cation efflux family; Region: Cation_efflux; cl00316
1118963003886	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1118963003887	Thioredoxin; Region: Thioredoxin_4; pfam13462
1118963003888	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1118963003889	Catalytic site [active]
1118963003890	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963003891	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963003892	DNA binding site [nucleotide binding]
1118963003893	domain linker motif; other site
1118963003894	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963003895	ligand binding site [chemical binding]; other site
1118963003896	dimerization interface [polypeptide binding]; other site
1118963003897	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1118963003898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963003899	putative substrate translocation pore; other site
1118963003900	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
1118963003901	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
1118963003902	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1118963003903	active site
1118963003904	DNA binding site [nucleotide binding]
1118963003905	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1118963003906	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
1118963003907	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1118963003908	active site
1118963003909	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1118963003910	DNA binding site [nucleotide binding]
1118963003911	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1118963003912	active site
1118963003913	SAM binding site [chemical binding]; other site
1118963003914	homodimer interface [polypeptide binding]; other site
1118963003915	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1118963003916	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963003917	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1118963003918	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1118963003919	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1118963003920	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
1118963003921	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1118963003922	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1118963003923	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1118963003924	active site
1118963003925	substrate binding site [chemical binding]; other site
1118963003926	metal binding site [ion binding]; metal-binding site
1118963003927	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1118963003928	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1118963003929	substrate binding [chemical binding]; other site
1118963003930	active site
1118963003931	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1118963003932	Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997
1118963003933	active site
1118963003934	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1118963003935	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
1118963003936	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
1118963003937	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963003938	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963003939	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1118963003940	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1118963003941	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1118963003942	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1118963003943	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1118963003944	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1118963003945	molybdopterin cofactor binding site; other site
1118963003946	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1118963003947	molybdopterin cofactor binding site; other site
1118963003948	lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150
1118963003949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963003950	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963003951	putative substrate translocation pore; other site
1118963003952	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1118963003953	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1118963003954	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1118963003955	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1118963003956	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1118963003957	carboxyltransferase (CT) interaction site; other site
1118963003958	biotinylation site [posttranslational modification]; other site
1118963003959	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1118963003960	active site
1118963003961	dimer interface [polypeptide binding]; other site
1118963003962	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1118963003963	MMPL family; Region: MMPL; cl14618
1118963003964	MMPL family; Region: MMPL; cl14618
1118963003965	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1118963003966	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963003967	Putative heavy-metal-binding; Region: YbjQ_1; pfam01906
1118963003968	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1118963003969	Bacterial protein of unknown function (DUF885); Region: DUF885; cl19872
1118963003970	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
1118963003971	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1118963003972	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
1118963003973	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
1118963003974	short chain dehydrogenase; Provisional; Region: PRK08278
1118963003975	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963003976	NAD(P) binding site [chemical binding]; other site
1118963003977	active site
1118963003978	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1118963003979	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1118963003980	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1118963003981	Bacterial PH domain; Region: bPH_2; pfam03703
1118963003982	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1118963003983	cyclase homology domain; Region: CHD; cd07302
1118963003984	nucleotidyl binding site; other site
1118963003985	metal binding site [ion binding]; metal-binding site
1118963003986	dimer interface [polypeptide binding]; other site
1118963003987	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1118963003988	Interdomain contacts; other site
1118963003989	Cytokine receptor motif; other site
1118963003990	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1118963003991	Interdomain contacts; other site
1118963003992	Cytokine receptor motif; other site
1118963003993	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1118963003994	Interdomain contacts; other site
1118963003995	Cytokine receptor motif; other site
1118963003996	MoxR-like ATPases [General function prediction only]; Region: COG0714
1118963003997	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963003998	Walker A motif; other site
1118963003999	ATP binding site [chemical binding]; other site
1118963004000	Walker B motif; other site
1118963004001	arginine finger; other site
1118963004002	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1118963004003	Protein of unknown function DUF58; Region: DUF58; pfam01882
1118963004004	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1118963004005	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1118963004006	Double zinc ribbon; Region: DZR; pfam12773
1118963004007	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1118963004008	RDD family; Region: RDD; pfam06271
1118963004009	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1118963004010	phosphopeptide binding site; other site
1118963004011	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1118963004012	active site
1118963004013	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1118963004014	FHA domain; Region: FHA; pfam00498
1118963004015	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1118963004016	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1118963004017	active site
1118963004018	ATP binding site [chemical binding]; other site
1118963004019	substrate binding site [chemical binding]; other site
1118963004020	activation loop (A-loop); other site
1118963004021	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1118963004022	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1118963004023	phosphopeptide binding site; other site
1118963004024	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1118963004025	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1118963004026	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1118963004027	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1118963004028	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1118963004029	nucleotide binding pocket [chemical binding]; other site
1118963004030	K-X-D-G motif; other site
1118963004031	catalytic site [active]
1118963004032	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1118963004033	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1118963004034	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
1118963004035	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1118963004036	Dimer interface [polypeptide binding]; other site
1118963004037	BRCT sequence motif; other site
1118963004038	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1118963004039	active site
1118963004040	Predicted ATPase [General function prediction only]; Region: COG4637
1118963004041	AAA domain; Region: AAA_23; pfam13476
1118963004042	Walker A/P-loop; other site
1118963004043	ATP binding site [chemical binding]; other site
1118963004044	AAA domain; Region: AAA_21; pfam13304
1118963004045	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963004046	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963004047	active site
1118963004048	catalytic tetrad [active]
1118963004049	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1118963004050	active site
1118963004051	non-prolyl cis peptide bond; other site
1118963004052	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1118963004053	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963004054	Walker A/P-loop; other site
1118963004055	ATP binding site [chemical binding]; other site
1118963004056	Q-loop/lid; other site
1118963004057	ABC transporter signature motif; other site
1118963004058	Walker B; other site
1118963004059	D-loop; other site
1118963004060	H-loop/switch region; other site
1118963004061	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1118963004062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963004063	dimer interface [polypeptide binding]; other site
1118963004064	conserved gate region; other site
1118963004065	putative PBP binding loops; other site
1118963004066	ABC-ATPase subunit interface; other site
1118963004067	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1118963004068	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1118963004069	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1118963004070	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963004071	Coenzyme A binding pocket [chemical binding]; other site
1118963004072	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
1118963004073	homotrimer interaction site [polypeptide binding]; other site
1118963004074	putative active site [active]
1118963004075	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1118963004076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963004077	active site
1118963004078	phosphorylation site [posttranslational modification]
1118963004079	intermolecular recognition site; other site
1118963004080	dimerization interface [polypeptide binding]; other site
1118963004081	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
1118963004082	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1118963004083	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
1118963004084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1118963004085	putative active site [active]
1118963004086	heme pocket [chemical binding]; other site
1118963004087	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
1118963004088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963004089	ATP binding site [chemical binding]; other site
1118963004090	Mg2+ binding site [ion binding]; other site
1118963004091	G-X-G motif; other site
1118963004092	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1118963004093	Citrate transporter; Region: CitMHS; pfam03600
1118963004094	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1118963004095	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1118963004096	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1118963004097	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1118963004098	GatB domain; Region: GatB_Yqey; smart00845
1118963004099	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1118963004100	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781
1118963004101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963004102	dimer interface [polypeptide binding]; other site
1118963004103	conserved gate region; other site
1118963004104	putative PBP binding loops; other site
1118963004105	ABC-ATPase subunit interface; other site
1118963004106	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963004107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963004108	dimer interface [polypeptide binding]; other site
1118963004109	conserved gate region; other site
1118963004110	putative PBP binding loops; other site
1118963004111	ABC-ATPase subunit interface; other site
1118963004112	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963004113	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963004114	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963004115	DNA binding site [nucleotide binding]
1118963004116	domain linker motif; other site
1118963004117	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963004118	dimerization interface [polypeptide binding]; other site
1118963004119	ligand binding site [chemical binding]; other site
1118963004120	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963004121	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963004122	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963004123	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963004124	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963004125	dimerization interface [polypeptide binding]; other site
1118963004126	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1118963004127	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1118963004128	NAD(P) binding site [chemical binding]; other site
1118963004129	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
1118963004130	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1118963004131	substrate-cofactor binding pocket; other site
1118963004132	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963004133	catalytic residue [active]
1118963004134	FAD dependent oxidoreductase; Region: DAO; pfam01266
1118963004135	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963004136	imidazolonepropionase; Provisional; Region: PRK14085
1118963004137	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963004138	active site
1118963004139	Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905
1118963004140	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
1118963004141	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
1118963004142	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
1118963004143	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1118963004144	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1118963004145	dimer interface [polypeptide binding]; other site
1118963004146	active site
1118963004147	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1118963004148	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963004149	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1118963004150	nucleotide binding site [chemical binding]; other site
1118963004151	Butyrate kinase [Energy production and conversion]; Region: COG3426
1118963004152	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1118963004153	ATP binding site [chemical binding]; other site
1118963004154	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1118963004155	intersubunit interface [polypeptide binding]; other site
1118963004156	active site
1118963004157	zinc binding site [ion binding]; other site
1118963004158	Na+ binding site [ion binding]; other site
1118963004159	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1118963004160	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1118963004161	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1118963004162	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1118963004163	catalytic core [active]
1118963004164	CAAX protease self-immunity; Region: Abi; pfam02517
1118963004165	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1118963004166	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1118963004167	homodimer interface [polypeptide binding]; other site
1118963004168	substrate-cofactor binding pocket; other site
1118963004169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963004170	catalytic residue [active]
1118963004171	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1118963004172	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1118963004173	Winged helix DNA-binding domain; Region: HTH_42; pfam06224
1118963004174	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
1118963004175	active site
1118963004176	catalytic triad [active]
1118963004177	oxyanion hole [active]
1118963004178	Predicted esterase [General function prediction only]; Region: COG0400
1118963004179	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963004180	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1118963004181	RNA binding surface [nucleotide binding]; other site
1118963004182	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1118963004183	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1118963004184	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1118963004185	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1118963004186	dimer interface [polypeptide binding]; other site
1118963004187	motif 1; other site
1118963004188	active site
1118963004189	motif 2; other site
1118963004190	motif 3; other site
1118963004191	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1118963004192	anticodon binding site; other site
1118963004193	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1118963004194	FAD binding domain; Region: FAD_binding_4; pfam01565
1118963004195	Berberine and berberine like; Region: BBE; pfam08031
1118963004196	YibE/F-like protein; Region: YibE_F; pfam07907
1118963004197	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1118963004198	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1118963004199	FMN binding site [chemical binding]; other site
1118963004200	active site
1118963004201	catalytic residues [active]
1118963004202	substrate binding site [chemical binding]; other site
1118963004203	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
1118963004204	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1118963004205	Zn2+ binding site [ion binding]; other site
1118963004206	Mg2+ binding site [ion binding]; other site
1118963004207	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1118963004208	DNA primase; Validated; Region: dnaG; PRK05667
1118963004209	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1118963004210	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1118963004211	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1118963004212	active site
1118963004213	metal binding site [ion binding]; metal-binding site
1118963004214	interdomain interaction site; other site
1118963004215	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1118963004216	Acyltransferase family; Region: Acyl_transf_3; cl19154
1118963004217	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
1118963004218	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1118963004219	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1118963004220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963004221	putative substrate translocation pore; other site
1118963004222	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1118963004223	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1118963004224	Multidrug resistance efflux transporter; Region: EmrE; cl19304
1118963004225	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
1118963004226	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1118963004227	putative ADP-binding pocket [chemical binding]; other site
1118963004228	Part of AAA domain; Region: AAA_19; pfam13245
1118963004229	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1118963004230	AAA domain; Region: AAA_12; pfam13087
1118963004231	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
1118963004232	acyl-coenzyme A oxidase; Region: PLN02526
1118963004233	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1118963004234	active site
1118963004235	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1118963004236	rRNA interaction site [nucleotide binding]; other site
1118963004237	S8 interaction site; other site
1118963004238	putative laminin-1 binding site; other site
1118963004239	elongation factor Ts; Provisional; Region: tsf; PRK09377
1118963004240	UBA/TS-N domain; Region: UBA; pfam00627
1118963004241	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1118963004242	putative nucleotide binding site [chemical binding]; other site
1118963004243	uridine monophosphate binding site [chemical binding]; other site
1118963004244	homohexameric interface [polypeptide binding]; other site
1118963004245	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1118963004246	hinge region; other site
1118963004247	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1118963004248	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
1118963004249	DivIVA domain; Region: DivI1A_domain; TIGR03544
1118963004250	DivIVA domain; Region: DivI1A_domain; TIGR03544
1118963004251	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1118963004252	Na binding site [ion binding]; other site
1118963004253	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1118963004254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963004255	active site
1118963004256	phosphorylation site [posttranslational modification]
1118963004257	intermolecular recognition site; other site
1118963004258	dimerization interface [polypeptide binding]; other site
1118963004259	LytTr DNA-binding domain; Region: LytTR; smart00850
1118963004260	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1118963004261	Histidine kinase; Region: His_kinase; pfam06580
1118963004262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963004263	ATP binding site [chemical binding]; other site
1118963004264	Mg2+ binding site [ion binding]; other site
1118963004265	G-X-G motif; other site
1118963004266	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1118963004267	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1118963004268	Na binding site [ion binding]; other site
1118963004269	hypothetical protein; Provisional; Region: PRK07945
1118963004270	Helix-hairpin-helix domain; Region: HHH_8; pfam14716
1118963004271	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1118963004272	active site
1118963004273	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
1118963004274	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
1118963004275	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963004276	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963004277	putative DNA binding site [nucleotide binding]; other site
1118963004278	putative Zn2+ binding site [ion binding]; other site
1118963004279	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1118963004280	tetramer interface [polypeptide binding]; other site
1118963004281	TPP-binding site [chemical binding]; other site
1118963004282	heterodimer interface [polypeptide binding]; other site
1118963004283	phosphorylation loop region [posttranslational modification]
1118963004284	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1118963004285	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1118963004286	alpha subunit interface [polypeptide binding]; other site
1118963004287	TPP binding site [chemical binding]; other site
1118963004288	heterodimer interface [polypeptide binding]; other site
1118963004289	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1118963004290	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1118963004291	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1118963004292	E3 interaction surface; other site
1118963004293	lipoyl attachment site [posttranslational modification]; other site
1118963004294	e3 binding domain; Region: E3_binding; pfam02817
1118963004295	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1118963004296	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963004297	extended (e) SDRs; Region: SDR_e; cd08946
1118963004298	NAD(P) binding site [chemical binding]; other site
1118963004299	active site
1118963004300	substrate binding site [chemical binding]; other site
1118963004301	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1118963004302	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963004303	active site
1118963004304	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963004305	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963004306	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1118963004307	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
1118963004308	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
1118963004309	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1118963004310	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1118963004311	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1118963004312	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1118963004313	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1118963004314	carboxyltransferase (CT) interaction site; other site
1118963004315	biotinylation site [posttranslational modification]; other site
1118963004316	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1118963004317	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1118963004318	active site
1118963004319	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1118963004320	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1118963004321	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1118963004322	putative active site [active]
1118963004323	putative catalytic site [active]
1118963004324	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1118963004325	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963004326	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963004327	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963004328	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1118963004329	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963004330	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963004331	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963004332	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963004333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963004334	dimer interface [polypeptide binding]; other site
1118963004335	conserved gate region; other site
1118963004336	putative PBP binding loops; other site
1118963004337	ABC-ATPase subunit interface; other site
1118963004338	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1118963004339	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963004340	dimer interface [polypeptide binding]; other site
1118963004341	conserved gate region; other site
1118963004342	putative PBP binding loops; other site
1118963004343	ABC-ATPase subunit interface; other site
1118963004344	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963004345	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1118963004346	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963004347	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963004348	DNA binding site [nucleotide binding]
1118963004349	Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296
1118963004350	putative dimerization interface [polypeptide binding]; other site
1118963004351	putative ligand binding site [chemical binding]; other site
1118963004352	Lipase maturation factor; Region: LMF1; pfam06762
1118963004353	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1118963004354	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1118963004355	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1118963004356	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1118963004357	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1118963004358	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1118963004359	active site
1118963004360	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1118963004361	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1118963004362	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1118963004363	putative substrate binding region [chemical binding]; other site
1118963004364	putative substrate binding region [chemical binding]; other site
1118963004365	YCII-related domain; Region: YCII; cl00999
1118963004366	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1118963004367	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
1118963004368	Predicted acetyltransferase [General function prediction only]; Region: COG3393
1118963004369	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
1118963004370	hypothetical protein; Provisional; Region: PRK11615
1118963004371	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963004372	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963004373	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1118963004374	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1118963004375	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1118963004376	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1118963004377	Walker A/P-loop; other site
1118963004378	ATP binding site [chemical binding]; other site
1118963004379	Q-loop/lid; other site
1118963004380	ABC transporter signature motif; other site
1118963004381	Walker B; other site
1118963004382	D-loop; other site
1118963004383	H-loop/switch region; other site
1118963004384	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1118963004385	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1118963004386	dimer interface [polypeptide binding]; other site
1118963004387	motif 1; other site
1118963004388	active site
1118963004389	motif 2; other site
1118963004390	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1118963004391	putative deacylase active site [active]
1118963004392	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1118963004393	active site
1118963004394	motif 3; other site
1118963004395	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1118963004396	anticodon binding site; other site
1118963004397	hypothetical protein; Provisional; Region: PRK10621
1118963004398	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
1118963004399	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1118963004400	Domain of unknown function (DUF4439); Region: DUF4439; pfam14530
1118963004401	Sm and related proteins; Region: Sm_like; cl00259
1118963004402	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1118963004403	putative oligomer interface [polypeptide binding]; other site
1118963004404	putative RNA binding site [nucleotide binding]; other site
1118963004405	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1118963004406	NusA N-terminal domain; Region: NusA_N; pfam08529
1118963004407	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1118963004408	RNA binding site [nucleotide binding]; other site
1118963004409	homodimer interface [polypeptide binding]; other site
1118963004410	NusA-like KH domain; Region: KH_5; pfam13184
1118963004411	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1118963004412	G-X-X-G motif; other site
1118963004413	Protein of unknown function (DUF448); Region: DUF448; pfam04296
1118963004414	putative RNA binding cleft [nucleotide binding]; other site
1118963004415	translation initiation factor IF-2; Validated; Region: infB; PRK05306
1118963004416	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1118963004417	Arsenite-resistance protein 2; Region: ARS2; pfam04959
1118963004418	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1118963004419	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1118963004420	G1 box; other site
1118963004421	putative GEF interaction site [polypeptide binding]; other site
1118963004422	GTP/Mg2+ binding site [chemical binding]; other site
1118963004423	Switch I region; other site
1118963004424	G2 box; other site
1118963004425	G3 box; other site
1118963004426	Switch II region; other site
1118963004427	G4 box; other site
1118963004428	G5 box; other site
1118963004429	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1118963004430	Translation-initiation factor 2; Region: IF-2; pfam11987
1118963004431	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1118963004432	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1118963004433	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1118963004434	nucleoside/Zn binding site; other site
1118963004435	dimer interface [polypeptide binding]; other site
1118963004436	catalytic motif [active]
1118963004437	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1118963004438	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963004439	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963004440	homodimer interface [polypeptide binding]; other site
1118963004441	catalytic residue [active]
1118963004442	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
1118963004443	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1118963004444	RNA binding site [nucleotide binding]; other site
1118963004445	active site
1118963004446	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
1118963004447	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1118963004448	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1118963004449	active site
1118963004450	Riboflavin kinase; Region: Flavokinase; smart00904
1118963004451	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1118963004452	16S/18S rRNA binding site [nucleotide binding]; other site
1118963004453	S13e-L30e interaction site [polypeptide binding]; other site
1118963004454	25S rRNA binding site [nucleotide binding]; other site
1118963004455	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
1118963004456	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1118963004457	oligomer interface [polypeptide binding]; other site
1118963004458	RNA binding site [nucleotide binding]; other site
1118963004459	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1118963004460	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1118963004461	RNase E interface [polypeptide binding]; other site
1118963004462	trimer interface [polypeptide binding]; other site
1118963004463	active site
1118963004464	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1118963004465	putative nucleic acid binding region [nucleotide binding]; other site
1118963004466	G-X-X-G motif; other site
1118963004467	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1118963004468	RNA binding site [nucleotide binding]; other site
1118963004469	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1118963004470	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1118963004471	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1118963004472	Ubiquitin-like proteins; Region: UBQ; cl00155
1118963004473	charged pocket; other site
1118963004474	hydrophobic patch; other site
1118963004475	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1118963004476	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1118963004477	FeS/SAM binding site; other site
1118963004478	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1118963004479	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1118963004480	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963004481	active site
1118963004482	phosphorylation site [posttranslational modification]
1118963004483	intermolecular recognition site; other site
1118963004484	dimerization interface [polypeptide binding]; other site
1118963004485	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1118963004486	DNA binding site [nucleotide binding]
1118963004487	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1118963004488	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1118963004489	dimer interface [polypeptide binding]; other site
1118963004490	phosphorylation site [posttranslational modification]
1118963004491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963004492	ATP binding site [chemical binding]; other site
1118963004493	Mg2+ binding site [ion binding]; other site
1118963004494	G-X-G motif; other site
1118963004495	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1118963004496	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1118963004497	Moco binding site; other site
1118963004498	metal coordination site [ion binding]; other site
1118963004499	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1118963004500	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1118963004501	dimer interface [polypeptide binding]; other site
1118963004502	putative functional site; other site
1118963004503	putative MPT binding site; other site
1118963004504	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1118963004505	trimer interface [polypeptide binding]; other site
1118963004506	dimer interface [polypeptide binding]; other site
1118963004507	putative active site [active]
1118963004508	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1118963004509	MPT binding site; other site
1118963004510	trimer interface [polypeptide binding]; other site
1118963004511	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1118963004512	MoaE homodimer interface [polypeptide binding]; other site
1118963004513	MoaD interaction [polypeptide binding]; other site
1118963004514	active site residues [active]
1118963004515	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1118963004516	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1118963004517	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1118963004518	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
1118963004519	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1118963004520	dimer interface [polypeptide binding]; other site
1118963004521	active site
1118963004522	catalytic residue [active]
1118963004523	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1118963004524	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1118963004525	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
1118963004526	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1118963004527	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1118963004528	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1118963004529	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1118963004530	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1118963004531	Competence-damaged protein; Region: CinA; pfam02464
1118963004532	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963004533	non-specific DNA binding site [nucleotide binding]; other site
1118963004534	salt bridge; other site
1118963004535	sequence-specific DNA binding site [nucleotide binding]; other site
1118963004536	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963004537	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963004538	putative Zn2+ binding site [ion binding]; other site
1118963004539	putative DNA binding site [nucleotide binding]; other site
1118963004540	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1118963004541	recombinase A; Provisional; Region: recA; PRK09354
1118963004542	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1118963004543	hexamer interface [polypeptide binding]; other site
1118963004544	Walker A motif; other site
1118963004545	ATP binding site [chemical binding]; other site
1118963004546	Walker B motif; other site
1118963004547	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1118963004548	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
1118963004549	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1118963004550	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1118963004551	FeS/SAM binding site; other site
1118963004552	TRAM domain; Region: TRAM; cl01282
1118963004553	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1118963004554	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1118963004555	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1118963004556	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
1118963004557	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963004558	S-adenosylmethionine binding site [chemical binding]; other site
1118963004559	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1118963004560	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1118963004561	HflX GTPase family; Region: HflX; cd01878
1118963004562	G1 box; other site
1118963004563	GTP/Mg2+ binding site [chemical binding]; other site
1118963004564	Switch I region; other site
1118963004565	G2 box; other site
1118963004566	G3 box; other site
1118963004567	Switch II region; other site
1118963004568	G4 box; other site
1118963004569	G5 box; other site
1118963004570	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1118963004571	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708
1118963004572	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1118963004573	LexA repressor; Validated; Region: PRK00215
1118963004574	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1118963004575	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1118963004576	Catalytic site [active]
1118963004577	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1118963004578	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1118963004579	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
1118963004580	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963004581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963004582	homodimer interface [polypeptide binding]; other site
1118963004583	catalytic residue [active]
1118963004584	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1118963004585	putative active site pocket [active]
1118963004586	4-fold oligomerization interface [polypeptide binding]; other site
1118963004587	metal binding residues [ion binding]; metal-binding site
1118963004588	3-fold/trimer interface [polypeptide binding]; other site
1118963004589	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1118963004590	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
1118963004591	putative active site [active]
1118963004592	oxyanion strand; other site
1118963004593	catalytic triad [active]
1118963004594	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1118963004595	catalytic residues [active]
1118963004596	SseB protein N-terminal domain; Region: SseB; pfam07179
1118963004597	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963004598	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963004599	translation initiation factor IF-3; Region: infC; TIGR00168
1118963004600	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1118963004601	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1118963004602	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1118963004603	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1118963004604	23S rRNA binding site [nucleotide binding]; other site
1118963004605	L21 binding site [polypeptide binding]; other site
1118963004606	L13 binding site [polypeptide binding]; other site
1118963004607	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
1118963004608	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1118963004609	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1118963004610	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1118963004611	Cation efflux family; Region: Cation_efflux; pfam01545
1118963004612	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1118963004613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963004614	putative substrate translocation pore; other site
1118963004615	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1118963004616	active site
1118963004617	8-oxo-dGMP binding site [chemical binding]; other site
1118963004618	nudix motif; other site
1118963004619	metal binding site [ion binding]; metal-binding site
1118963004620	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1118963004621	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1118963004622	FeS/SAM binding site; other site
1118963004623	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1118963004624	putative substrate binding pocket [chemical binding]; other site
1118963004625	AC domain interface; other site
1118963004626	catalytic triad [active]
1118963004627	AB domain interface; other site
1118963004628	interchain disulfide; other site
1118963004629	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1118963004630	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1118963004631	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1118963004632	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1118963004633	dimer interface [polypeptide binding]; other site
1118963004634	motif 1; other site
1118963004635	active site
1118963004636	motif 2; other site
1118963004637	motif 3; other site
1118963004638	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1118963004639	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1118963004640	putative tRNA-binding site [nucleotide binding]; other site
1118963004641	B3/4 domain; Region: B3_4; pfam03483
1118963004642	tRNA synthetase B5 domain; Region: B5; pfam03484
1118963004643	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1118963004644	dimer interface [polypeptide binding]; other site
1118963004645	motif 1; other site
1118963004646	motif 3; other site
1118963004647	motif 2; other site
1118963004648	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1118963004649	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1118963004650	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1118963004651	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
1118963004652	Zn binding site [ion binding]; other site
1118963004653	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1118963004654	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1118963004655	acyl-activating enzyme (AAE) consensus motif; other site
1118963004656	AMP binding site [chemical binding]; other site
1118963004657	active site
1118963004658	CoA binding site [chemical binding]; other site
1118963004659	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1118963004660	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
1118963004661	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1118963004662	putative trimer interface [polypeptide binding]; other site
1118963004663	putative CoA binding site [chemical binding]; other site
1118963004664	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1118963004665	putative CoA binding site [chemical binding]; other site
1118963004666	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1118963004667	putative trimer interface [polypeptide binding]; other site
1118963004668	putative CoA binding site [chemical binding]; other site
1118963004669	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1118963004670	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1118963004671	NADP binding site [chemical binding]; other site
1118963004672	dimer interface [polypeptide binding]; other site
1118963004673	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1118963004674	putative di-iron ligands [ion binding]; other site
1118963004675	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1118963004676	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1118963004677	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
1118963004678	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1118963004679	heterotetramer interface [polypeptide binding]; other site
1118963004680	active site pocket [active]
1118963004681	cleavage site
1118963004682	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1118963004683	feedback inhibition sensing region; other site
1118963004684	homohexameric interface [polypeptide binding]; other site
1118963004685	nucleotide binding site [chemical binding]; other site
1118963004686	N-acetyl-L-glutamate binding site [chemical binding]; other site
1118963004687	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1118963004688	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1118963004689	inhibitor-cofactor binding pocket; inhibition site
1118963004690	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963004691	catalytic residue [active]
1118963004692	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1118963004693	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1118963004694	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1118963004695	arginine repressor; Provisional; Region: PRK03341
1118963004696	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1118963004697	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1118963004698	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1118963004699	ANP binding site [chemical binding]; other site
1118963004700	Substrate Binding Site II [chemical binding]; other site
1118963004701	Substrate Binding Site I [chemical binding]; other site
1118963004702	argininosuccinate lyase; Provisional; Region: PRK00855
1118963004703	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1118963004704	active sites [active]
1118963004705	tetramer interface [polypeptide binding]; other site
1118963004706	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
1118963004707	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1118963004708	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1118963004709	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1118963004710	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1118963004711	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1118963004712	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1118963004713	minor groove reading motif; other site
1118963004714	helix-hairpin-helix signature motif; other site
1118963004715	substrate binding pocket [chemical binding]; other site
1118963004716	active site
1118963004717	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1118963004718	active site
1118963004719	DNA binding site [nucleotide binding]
1118963004720	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1118963004721	Part of AAA domain; Region: AAA_19; pfam13245
1118963004722	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
1118963004723	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1118963004724	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1118963004725	active site
1118963004726	HIGH motif; other site
1118963004727	dimer interface [polypeptide binding]; other site
1118963004728	KMSKS motif; other site
1118963004729	S4 RNA-binding domain; Region: S4; smart00363
1118963004730	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1118963004731	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1118963004732	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963004733	active site
1118963004734	motif I; other site
1118963004735	motif II; other site
1118963004736	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1118963004737	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1118963004738	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1118963004739	RNA binding surface [nucleotide binding]; other site
1118963004740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963004741	S-adenosylmethionine binding site [chemical binding]; other site
1118963004742	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
1118963004743	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1118963004744	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1118963004745	Walker A/P-loop; other site
1118963004746	ATP binding site [chemical binding]; other site
1118963004747	Q-loop/lid; other site
1118963004748	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1118963004749	ABC transporter signature motif; other site
1118963004750	Walker B; other site
1118963004751	D-loop; other site
1118963004752	H-loop/switch region; other site
1118963004753	CTP synthetase; Validated; Region: pyrG; PRK05380
1118963004754	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1118963004755	Catalytic site [active]
1118963004756	active site
1118963004757	UTP binding site [chemical binding]; other site
1118963004758	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1118963004759	active site
1118963004760	putative oxyanion hole; other site
1118963004761	catalytic triad [active]
1118963004762	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1118963004763	dimer interface [polypeptide binding]; other site
1118963004764	ADP-ribose binding site [chemical binding]; other site
1118963004765	active site
1118963004766	nudix motif; other site
1118963004767	metal binding site [ion binding]; metal-binding site
1118963004768	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1118963004769	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1118963004770	active site
1118963004771	Int/Topo IB signature motif; other site
1118963004772	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1118963004773	nudix motif; other site
1118963004774	citrate synthase; Provisional; Region: PRK14033
1118963004775	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1118963004776	oxalacetate binding site [chemical binding]; other site
1118963004777	citrylCoA binding site [chemical binding]; other site
1118963004778	coenzyme A binding site [chemical binding]; other site
1118963004779	catalytic triad [active]
1118963004780	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1118963004781	tetramer interface [polypeptide binding]; other site
1118963004782	active site
1118963004783	Mg2+/Mn2+ binding site [ion binding]; other site
1118963004784	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1118963004785	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1118963004786	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963004787	DNA-binding site [nucleotide binding]; DNA binding site
1118963004788	FCD domain; Region: FCD; pfam07729
1118963004789	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1118963004790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963004791	S-adenosylmethionine binding site [chemical binding]; other site
1118963004792	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963004793	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963004794	DNA binding residues [nucleotide binding]
1118963004795	dimerization interface [polypeptide binding]; other site
1118963004796	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1118963004797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963004798	active site
1118963004799	phosphorylation site [posttranslational modification]
1118963004800	intermolecular recognition site; other site
1118963004801	dimerization interface [polypeptide binding]; other site
1118963004802	FaeA-like protein; Region: FaeA; pfam04703
1118963004803	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1118963004804	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
1118963004805	PAS domain; Region: PAS_8; pfam13188
1118963004806	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
1118963004807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963004808	ATP binding site [chemical binding]; other site
1118963004809	Mg2+ binding site [ion binding]; other site
1118963004810	G-X-G motif; other site
1118963004811	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1118963004812	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1118963004813	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1118963004814	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1118963004815	P-loop; other site
1118963004816	Magnesium ion binding site [ion binding]; other site
1118963004817	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1118963004818	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1118963004819	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1118963004820	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1118963004821	RNA binding surface [nucleotide binding]; other site
1118963004822	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1118963004823	active site
1118963004824	prephenate dehydrogenase; Validated; Region: PRK06545
1118963004825	prephenate dehydrogenase; Validated; Region: PRK08507
1118963004826	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1118963004827	cytidylate kinase; Provisional; Region: cmk; PRK00023
1118963004828	Cytidylate kinase; Region: Cytidylate_kin; pfam02224
1118963004829	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1118963004830	putative acyl-acceptor binding pocket; other site
1118963004831	GTP-binding protein Der; Reviewed; Region: PRK03003
1118963004832	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1118963004833	G1 box; other site
1118963004834	GTP/Mg2+ binding site [chemical binding]; other site
1118963004835	Switch I region; other site
1118963004836	G2 box; other site
1118963004837	Switch II region; other site
1118963004838	G3 box; other site
1118963004839	G4 box; other site
1118963004840	G5 box; other site
1118963004841	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1118963004842	G1 box; other site
1118963004843	GTP/Mg2+ binding site [chemical binding]; other site
1118963004844	Switch I region; other site
1118963004845	G2 box; other site
1118963004846	G3 box; other site
1118963004847	Switch II region; other site
1118963004848	G4 box; other site
1118963004849	G5 box; other site
1118963004850	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
1118963004851	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963004852	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963004853	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1118963004854	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963004855	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1118963004856	lipoyl attachment site [posttranslational modification]; other site
1118963004857	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1118963004858	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1118963004859	phosphopeptide binding site; other site
1118963004860	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1118963004861	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1118963004862	DNA binding residues [nucleotide binding]
1118963004863	Bifunctional nuclease; Region: DNase-RNase; pfam02577
1118963004864	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1118963004865	DNA binding residues [nucleotide binding]
1118963004866	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1118963004867	putative dimer interface [polypeptide binding]; other site
1118963004868	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1118963004869	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1118963004870	P-loop; other site
1118963004871	Magnesium ion binding site [ion binding]; other site
1118963004872	pyruvate carboxylase; Reviewed; Region: PRK12999
1118963004873	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1118963004874	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1118963004875	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1118963004876	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1118963004877	active site
1118963004878	catalytic residues [active]
1118963004879	metal binding site [ion binding]; metal-binding site
1118963004880	homodimer binding site [polypeptide binding]; other site
1118963004881	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
1118963004882	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1118963004883	carboxyltransferase (CT) interaction site; other site
1118963004884	biotinylation site [posttranslational modification]; other site
1118963004885	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1118963004886	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1118963004887	acyl-activating enzyme (AAE) consensus motif; other site
1118963004888	putative AMP binding site [chemical binding]; other site
1118963004889	putative active site [active]
1118963004890	putative CoA binding site [chemical binding]; other site
1118963004891	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1118963004892	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1118963004893	nucleotide binding site [chemical binding]; other site
1118963004894	Esterase/lipase [General function prediction only]; Region: COG1647
1118963004895	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963004896	Esterase/lipase [General function prediction only]; Region: COG1647
1118963004897	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963004898	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1118963004899	putative acyl-acceptor binding pocket; other site
1118963004900	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1118963004901	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1118963004902	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1118963004903	active site
1118963004904	ATP binding site [chemical binding]; other site
1118963004905	substrate binding site [chemical binding]; other site
1118963004906	activation loop (A-loop); other site
1118963004907	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1118963004908	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1118963004909	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1118963004910	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1118963004911	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1118963004912	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1118963004913	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1118963004914	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1118963004915	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1118963004916	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1118963004917	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1118963004918	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1118963004919	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1118963004920	catalytic residue [active]
1118963004921	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1118963004922	substrate binding pocket [chemical binding]; other site
1118963004923	chain length determination region; other site
1118963004924	substrate-Mg2+ binding site; other site
1118963004925	catalytic residues [active]
1118963004926	aspartate-rich region 1; other site
1118963004927	active site lid residues [active]
1118963004928	aspartate-rich region 2; other site
1118963004929	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1118963004930	active site
1118963004931	DNA polymerase IV; Validated; Region: PRK02406
1118963004932	DNA binding site [nucleotide binding]
1118963004933	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
1118963004934	cell division protein MraZ; Reviewed; Region: PRK00326
1118963004935	MraZ protein; Region: MraZ; pfam02381
1118963004936	MraZ protein; Region: MraZ; pfam02381
1118963004937	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1118963004938	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1118963004939	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
1118963004940	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1118963004941	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1118963004942	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1118963004943	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1118963004944	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1118963004945	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1118963004946	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1118963004947	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1118963004948	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1118963004949	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1118963004950	Mg++ binding site [ion binding]; other site
1118963004951	putative catalytic motif [active]
1118963004952	putative substrate binding site [chemical binding]; other site
1118963004953	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
1118963004954	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125
1118963004955	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1118963004956	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1118963004957	cell division protein FtsW; Region: ftsW; TIGR02614
1118963004958	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1118963004959	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1118963004960	active site
1118963004961	homodimer interface [polypeptide binding]; other site
1118963004962	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1118963004963	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1118963004964	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1118963004965	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1118963004966	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1118963004967	Cell division protein FtsQ; Region: FtsQ; pfam03799
1118963004968	cell division protein FtsZ; Validated; Region: PRK09330
1118963004969	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1118963004970	nucleotide binding site [chemical binding]; other site
1118963004971	SulA interaction site; other site
1118963004972	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1118963004973	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1118963004974	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1118963004975	catalytic residue [active]
1118963004976	Protein of unknown function (DUF552); Region: DUF552; pfam04472
1118963004977	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
1118963004978	lipoprotein signal peptidase; Provisional; Region: PRK14772
1118963004979	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1118963004980	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1118963004981	active site
1118963004982	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1118963004983	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1118963004984	active site
1118963004985	PHP Thumb interface [polypeptide binding]; other site
1118963004986	metal binding site [ion binding]; metal-binding site
1118963004987	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1118963004988	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
1118963004989	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1118963004990	generic binding surface II; other site
1118963004991	generic binding surface I; other site
1118963004992	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1118963004993	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
1118963004994	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1118963004995	histidinol dehydrogenase; Region: hisD; TIGR00069
1118963004996	NAD binding site [chemical binding]; other site
1118963004997	dimerization interface [polypeptide binding]; other site
1118963004998	product binding site; other site
1118963004999	substrate binding site [chemical binding]; other site
1118963005000	zinc binding site [ion binding]; other site
1118963005001	catalytic residues [active]
1118963005002	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1118963005003	ATP cone domain; Region: ATP-cone; pfam03477
1118963005004	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963005005	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1118963005006	NAD(P) binding site [chemical binding]; other site
1118963005007	active site
1118963005008	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1118963005009	nucleotide binding site [chemical binding]; other site
1118963005010	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963005011	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1118963005012	active site
1118963005013	Sporulation related domain; Region: SPOR; pfam05036
1118963005014	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1118963005015	oligomerization interface [polypeptide binding]; other site
1118963005016	active site
1118963005017	metal binding site [ion binding]; metal-binding site
1118963005018	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1118963005019	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1118963005020	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1118963005021	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
1118963005022	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1118963005023	metal binding triad; other site
1118963005024	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1118963005025	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1118963005026	metal binding triad; other site
1118963005027	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1118963005028	arylsulfatase; Provisional; Region: PRK13759
1118963005029	Sulfatase; Region: Sulfatase; pfam00884
1118963005030	glutamine synthetase, type I; Region: GlnA; TIGR00653
1118963005031	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1118963005032	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1118963005033	RDD family; Region: RDD; pfam06271
1118963005034	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
1118963005035	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1118963005036	lipoyl synthase; Provisional; Region: PRK05481
1118963005037	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1118963005038	FeS/SAM binding site; other site
1118963005039	lipoate-protein ligase B; Provisional; Region: PRK14345
1118963005040	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1118963005041	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1118963005042	active site
1118963005043	ATP binding site [chemical binding]; other site
1118963005044	substrate binding site [chemical binding]; other site
1118963005045	activation loop (A-loop); other site
1118963005046	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963005047	TIGR01777 family protein; Region: yfcH
1118963005048	NAD(P) binding site [chemical binding]; other site
1118963005049	active site
1118963005050	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
1118963005051	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1118963005052	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
1118963005053	Domain interface; other site
1118963005054	Active site tetrad [active]
1118963005055	Peptide binding site; other site
1118963005056	Tricorn protease PDZ domain; Region: Tricorn_PDZ; pfam14685
1118963005057	protein binding site [polypeptide binding]; other site
1118963005058	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
1118963005059	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1118963005060	active site
1118963005061	metal binding site [ion binding]; metal-binding site
1118963005062	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927
1118963005063	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1118963005064	E3 interaction surface; other site
1118963005065	lipoyl attachment site [posttranslational modification]; other site
1118963005066	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1118963005067	E3 interaction surface; other site
1118963005068	lipoyl attachment site [posttranslational modification]; other site
1118963005069	e3 binding domain; Region: E3_binding; pfam02817
1118963005070	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1118963005071	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1118963005072	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963005073	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963005074	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1118963005075	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1118963005076	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1118963005077	interface (dimer of trimers) [polypeptide binding]; other site
1118963005078	Substrate-binding/catalytic site; other site
1118963005079	Zn-binding sites [ion binding]; other site
1118963005080	PAC2 family; Region: PAC2; pfam09754
1118963005081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005082	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963005083	putative substrate translocation pore; other site
1118963005084	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1118963005085	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
1118963005086	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1118963005087	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1118963005088	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963005089	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1118963005090	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1118963005091	DNA binding residues [nucleotide binding]
1118963005092	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1118963005093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963005094	ATP binding site [chemical binding]; other site
1118963005095	Mg2+ binding site [ion binding]; other site
1118963005096	G-X-G motif; other site
1118963005097	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1118963005098	anchoring element; other site
1118963005099	dimer interface [polypeptide binding]; other site
1118963005100	ATP binding site [chemical binding]; other site
1118963005101	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1118963005102	active site
1118963005103	metal binding site [ion binding]; metal-binding site
1118963005104	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1118963005105	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005106	putative substrate translocation pore; other site
1118963005107	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963005108	Peptidase family M48; Region: Peptidase_M48; cl12018
1118963005109	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
1118963005110	Penicillinase repressor; Region: Penicillinase_R; cl17580
1118963005111	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1118963005112	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1118963005113	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1118963005114	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
1118963005115	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963005116	Walker A/P-loop; other site
1118963005117	ATP binding site [chemical binding]; other site
1118963005118	Q-loop/lid; other site
1118963005119	ABC transporter signature motif; other site
1118963005120	Walker B; other site
1118963005121	D-loop; other site
1118963005122	H-loop/switch region; other site
1118963005123	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1118963005124	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963005125	Walker A/P-loop; other site
1118963005126	ATP binding site [chemical binding]; other site
1118963005127	Q-loop/lid; other site
1118963005128	ABC transporter signature motif; other site
1118963005129	Walker B; other site
1118963005130	D-loop; other site
1118963005131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1118963005132	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1118963005133	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963005134	Coenzyme A binding pocket [chemical binding]; other site
1118963005135	DinB superfamily; Region: DinB_2; pfam12867
1118963005136	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1118963005137	active site
1118963005138	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1118963005139	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1118963005140	CAP-like domain; other site
1118963005141	active site
1118963005142	primary dimer interface [polypeptide binding]; other site
1118963005143	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1118963005144	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1118963005145	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963005146	Coenzyme A binding pocket [chemical binding]; other site
1118963005147	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
1118963005148	CoA binding domain; Region: CoA_binding_2; pfam13380
1118963005149	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1118963005150	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1118963005151	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
1118963005152	thymidine kinase; Provisional; Region: PRK04296
1118963005153	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
1118963005154	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1118963005155	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
1118963005156	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1118963005157	trimer interface [polypeptide binding]; other site
1118963005158	active site
1118963005159	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
1118963005160	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
1118963005161	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1118963005162	TrkA-N domain; Region: TrkA_N; pfam02254
1118963005163	TrkA-C domain; Region: TrkA_C; pfam02080
1118963005164	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1118963005165	TrkA-N domain; Region: TrkA_N; pfam02254
1118963005166	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963005167	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
1118963005168	TRAM domain; Region: TRAM; cl01282
1118963005169	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1118963005170	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963005171	S-adenosylmethionine binding site [chemical binding]; other site
1118963005172	aconitate hydratase; Validated; Region: PRK09277
1118963005173	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1118963005174	substrate binding site [chemical binding]; other site
1118963005175	ligand binding site [chemical binding]; other site
1118963005176	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1118963005177	substrate binding site [chemical binding]; other site
1118963005178	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1118963005179	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1118963005180	TPP-binding site; other site
1118963005181	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1118963005182	PYR/PP interface [polypeptide binding]; other site
1118963005183	dimer interface [polypeptide binding]; other site
1118963005184	TPP binding site [chemical binding]; other site
1118963005185	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1118963005186	Protein of unknown function (DUF402); Region: DUF402; cl00979
1118963005187	Protein of unknown function (DUF402); Region: DUF402; cl00979
1118963005188	hypothetical protein; Provisional; Region: PRK07758
1118963005189	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963005190	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963005191	active site
1118963005192	catalytic tetrad [active]
1118963005193	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1118963005194	substrate binding site [chemical binding]; other site
1118963005195	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1118963005196	oxyanion hole (OAH) forming residues; other site
1118963005197	trimer interface [polypeptide binding]; other site
1118963005198	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1118963005199	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1118963005200	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1118963005201	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1118963005202	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
1118963005203	dimer interface [polypeptide binding]; other site
1118963005204	active site
1118963005205	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1118963005206	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1118963005207	catalytic site [active]
1118963005208	putative active site [active]
1118963005209	putative substrate binding site [chemical binding]; other site
1118963005210	HRDC domain; Region: HRDC; cl02578
1118963005211	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
1118963005212	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1118963005213	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
1118963005214	tetramer interface [polypeptide binding]; other site
1118963005215	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963005216	catalytic residue [active]
1118963005217	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1118963005218	classical (c) SDRs; Region: SDR_c; cd05233
1118963005219	NAD(P) binding site [chemical binding]; other site
1118963005220	active site
1118963005221	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1118963005222	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963005223	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963005224	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1118963005225	putative deacylase active site [active]
1118963005226	Fe-S metabolizm associated domain; Region: SufE; cl00951
1118963005227	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1118963005228	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1118963005229	active site residue [active]
1118963005230	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1118963005231	active site residue [active]
1118963005232	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
1118963005233	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
1118963005234	Sulfate transporter family; Region: Sulfate_transp; cl19250
1118963005235	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
1118963005236	amino acid transporter; Region: 2A0306; TIGR00909
1118963005237	Spore germination protein; Region: Spore_permease; cl17796
1118963005238	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1118963005239	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1118963005240	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1118963005241	active site
1118963005242	catalytic residues [active]
1118963005243	metal binding site [ion binding]; metal-binding site
1118963005244	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1118963005245	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1118963005246	putative active site [active]
1118963005247	substrate binding site [chemical binding]; other site
1118963005248	putative cosubstrate binding site; other site
1118963005249	catalytic site [active]
1118963005250	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1118963005251	substrate binding site [chemical binding]; other site
1118963005252	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1118963005253	putative RNA binding site [nucleotide binding]; other site
1118963005254	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1118963005255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963005256	S-adenosylmethionine binding site [chemical binding]; other site
1118963005257	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1118963005258	substrate binding site [chemical binding]; other site
1118963005259	hexamer interface [polypeptide binding]; other site
1118963005260	metal binding site [ion binding]; metal-binding site
1118963005261	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
1118963005262	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
1118963005263	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1118963005264	active site
1118963005265	Zn binding site [ion binding]; other site
1118963005266	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1118963005267	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1118963005268	Lumazine binding domain; Region: Lum_binding; pfam00677
1118963005269	Lumazine binding domain; Region: Lum_binding; pfam00677
1118963005270	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1118963005271	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1118963005272	dimerization interface [polypeptide binding]; other site
1118963005273	active site
1118963005274	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1118963005275	homopentamer interface [polypeptide binding]; other site
1118963005276	active site
1118963005277	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
1118963005278	homodimer interface [polypeptide binding]; other site
1118963005279	putative metal binding site [ion binding]; other site
1118963005280	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1118963005281	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1118963005282	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1118963005283	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1118963005284	substrate binding site [chemical binding]; other site
1118963005285	glutamase interaction surface [polypeptide binding]; other site
1118963005286	TIGR03085 family protein; Region: TIGR03085
1118963005287	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1118963005288	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1118963005289	anthranilate synthase component I; Provisional; Region: PRK13571
1118963005290	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1118963005291	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1118963005292	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850
1118963005293	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1118963005294	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1118963005295	active site
1118963005296	ribulose/triose binding site [chemical binding]; other site
1118963005297	phosphate binding site [ion binding]; other site
1118963005298	substrate (anthranilate) binding pocket [chemical binding]; other site
1118963005299	product (indole) binding pocket [chemical binding]; other site
1118963005300	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1118963005301	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963005302	catalytic residue [active]
1118963005303	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1118963005304	substrate binding site [chemical binding]; other site
1118963005305	active site
1118963005306	catalytic residues [active]
1118963005307	heterodimer interface [polypeptide binding]; other site
1118963005308	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1118963005309	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1118963005310	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1118963005311	active site
1118963005312	dimer interface [polypeptide binding]; other site
1118963005313	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1118963005314	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1118963005315	active site
1118963005316	FMN binding site [chemical binding]; other site
1118963005317	substrate binding site [chemical binding]; other site
1118963005318	3Fe-4S cluster binding site [ion binding]; other site
1118963005319	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1118963005320	domain interface; other site
1118963005321	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1118963005322	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
1118963005323	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963005324	pyruvate kinase; Provisional; Region: PRK06247
1118963005325	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
1118963005326	active site
1118963005327	domain interfaces; other site
1118963005328	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1118963005329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963005330	active site
1118963005331	phosphorylation site [posttranslational modification]
1118963005332	intermolecular recognition site; other site
1118963005333	dimerization interface [polypeptide binding]; other site
1118963005334	ANTAR domain; Region: ANTAR; pfam03861
1118963005335	Microtubule associated protein (MAP65/ASE1 family); Region: MAP65_ASE1; pfam03999
1118963005336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
1118963005337	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1118963005338	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1118963005339	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1118963005340	binding surface
1118963005341	TPR motif; other site
1118963005342	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1118963005343	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1118963005344	binding surface
1118963005345	TPR motif; other site
1118963005346	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1118963005347	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1118963005348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1118963005349	binding surface
1118963005350	TPR motif; other site
1118963005351	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1118963005352	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1118963005353	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1118963005354	PLD-like domain; Region: PLDc_2; pfam13091
1118963005355	putative active site [active]
1118963005356	catalytic site [active]
1118963005357	Domain of unknown function (DUF4209); Region: DUF4209; pfam13910
1118963005358	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963005359	active site
1118963005360	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963005361	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963005362	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1118963005363	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963005364	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963005365	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963005366	dimerization interface [polypeptide binding]; other site
1118963005367	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963005368	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963005369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963005370	dimer interface [polypeptide binding]; other site
1118963005371	conserved gate region; other site
1118963005372	putative PBP binding loops; other site
1118963005373	ABC-ATPase subunit interface; other site
1118963005374	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963005375	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963005376	dimer interface [polypeptide binding]; other site
1118963005377	conserved gate region; other site
1118963005378	putative PBP binding loops; other site
1118963005379	ABC-ATPase subunit interface; other site
1118963005380	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1118963005381	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1118963005382	pyranose oxidase; Region: pyranose_ox; TIGR02462
1118963005383	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1118963005384	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963005385	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963005386	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963005387	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963005388	SnoaL-like domain; Region: SnoaL_4; pfam13577
1118963005389	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963005390	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963005391	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963005392	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963005393	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963005394	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1118963005395	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963005396	classical (c) SDRs; Region: SDR_c; cd05233
1118963005397	NAD(P) binding site [chemical binding]; other site
1118963005398	active site
1118963005399	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1118963005400	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963005401	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1118963005402	nucleotide binding site [chemical binding]; other site
1118963005403	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963005404	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963005405	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963005406	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
1118963005407	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1118963005408	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
1118963005409	active site
1118963005410	metal binding site [ion binding]; metal-binding site
1118963005411	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1118963005412	active site
1118963005413	metal binding site [ion binding]; metal-binding site
1118963005414	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1118963005415	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1118963005416	Putative cyclase; Region: Cyclase; pfam04199
1118963005417	hypothetical protein; Provisional; Region: PRK06847
1118963005418	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963005419	Amidohydrolase; Region: Amidohydro_2; pfam04909
1118963005420	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1118963005421	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1118963005422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005423	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963005424	putative substrate translocation pore; other site
1118963005425	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1118963005426	pyranose oxidase; Region: pyranose_ox; TIGR02462
1118963005427	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1118963005428	YciI-like protein; Reviewed; Region: PRK12866
1118963005429	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1118963005430	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963005431	Coenzyme A binding pocket [chemical binding]; other site
1118963005432	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963005433	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963005434	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1118963005435	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1118963005436	dimer interface [polypeptide binding]; other site
1118963005437	active site
1118963005438	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963005439	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963005440	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963005441	non-specific DNA binding site [nucleotide binding]; other site
1118963005442	salt bridge; other site
1118963005443	sequence-specific DNA binding site [nucleotide binding]; other site
1118963005444	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963005445	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963005446	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1118963005447	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
1118963005448	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1118963005449	C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299
1118963005450	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1118963005451	ligand binding site [chemical binding]; other site
1118963005452	NAD binding site [chemical binding]; other site
1118963005453	catalytic site [active]
1118963005454	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
1118963005455	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1118963005456	inhibitor-cofactor binding pocket; inhibition site
1118963005457	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963005458	catalytic residue [active]
1118963005459	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1118963005460	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1118963005461	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1118963005462	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1118963005463	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1118963005464	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816
1118963005465	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963005466	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963005467	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963005468	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1118963005469	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1118963005470	PYR/PP interface [polypeptide binding]; other site
1118963005471	dimer interface [polypeptide binding]; other site
1118963005472	TPP binding site [chemical binding]; other site
1118963005473	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1118963005474	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1118963005475	TPP-binding site [chemical binding]; other site
1118963005476	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1118963005477	NAD(P) binding site [chemical binding]; other site
1118963005478	catalytic residues [active]
1118963005479	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963005480	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963005481	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963005482	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963005483	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963005484	NAD(P) binding site [chemical binding]; other site
1118963005485	active site
1118963005486	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1118963005487	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1118963005488	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
1118963005489	NAD binding site [chemical binding]; other site
1118963005490	ligand binding site [chemical binding]; other site
1118963005491	catalytic site [active]
1118963005492	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963005493	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963005494	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963005495	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963005496	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963005497	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1118963005498	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1118963005499	Walker A/P-loop; other site
1118963005500	ATP binding site [chemical binding]; other site
1118963005501	Q-loop/lid; other site
1118963005502	ABC transporter signature motif; other site
1118963005503	Walker B; other site
1118963005504	D-loop; other site
1118963005505	H-loop/switch region; other site
1118963005506	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1118963005507	TM-ABC transporter signature motif; other site
1118963005508	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1118963005509	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1118963005510	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1118963005511	FAD binding domain; Region: FAD_binding_4; pfam01565
1118963005512	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
1118963005513	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1118963005514	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1118963005515	Allophanate hydrolase subunit 1; Region: AHS1; cl19310
1118963005516	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963005517	Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382
1118963005518	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963005519	TrwC relaxase; Region: TrwC; cl19905
1118963005520	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
1118963005521	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
1118963005522	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1118963005523	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1118963005524	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963005525	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963005526	Reductase C-terminal; Region: Reductase_C; pfam14759
1118963005527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005528	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963005529	putative substrate translocation pore; other site
1118963005530	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1118963005531	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963005532	short chain dehydrogenase; Provisional; Region: PRK06138
1118963005533	classical (c) SDRs; Region: SDR_c; cd05233
1118963005534	NAD(P) binding site [chemical binding]; other site
1118963005535	active site
1118963005536	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1118963005537	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1118963005538	NAD(P) binding site [chemical binding]; other site
1118963005539	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1118963005540	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1118963005541	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1118963005542	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1118963005543	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963005544	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963005545	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963005546	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963005547	classical (c) SDRs; Region: SDR_c; cd05233
1118963005548	NAD(P) binding site [chemical binding]; other site
1118963005549	active site
1118963005550	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1118963005551	FAD binding domain; Region: FAD_binding_4; pfam01565
1118963005552	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
1118963005553	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1118963005554	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
1118963005555	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1118963005556	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
1118963005557	active site
1118963005558	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1118963005559	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1118963005560	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1118963005561	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1118963005562	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1118963005563	Filamin/ABP280 repeat; Region: Filamin; cl19759
1118963005564	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
1118963005565	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963005566	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
1118963005567	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963005568	dimerization interface [polypeptide binding]; other site
1118963005569	ligand binding site [chemical binding]; other site
1118963005570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963005571	dimer interface [polypeptide binding]; other site
1118963005572	conserved gate region; other site
1118963005573	putative PBP binding loops; other site
1118963005574	ABC-ATPase subunit interface; other site
1118963005575	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963005576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963005577	dimer interface [polypeptide binding]; other site
1118963005578	conserved gate region; other site
1118963005579	putative PBP binding loops; other site
1118963005580	ABC-ATPase subunit interface; other site
1118963005581	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963005582	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963005583	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963005584	Q-loop/lid; other site
1118963005585	ABC transporter signature motif; other site
1118963005586	Walker B; other site
1118963005587	D-loop; other site
1118963005588	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1118963005589	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1118963005590	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1118963005591	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005592	putative substrate translocation pore; other site
1118963005593	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
1118963005594	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963005595	classical (c) SDRs; Region: SDR_c; cd05233
1118963005596	NAD(P) binding site [chemical binding]; other site
1118963005597	active site
1118963005598	MFS/sugar transport protein; Region: MFS_2; pfam13347
1118963005599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005600	putative substrate translocation pore; other site
1118963005601	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963005602	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963005603	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1118963005604	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1118963005605	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
1118963005606	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963005607	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963005608	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1118963005609	substrate binding site [chemical binding]; other site
1118963005610	dimer interface [polypeptide binding]; other site
1118963005611	catalytic triad [active]
1118963005612	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
1118963005613	dihydroxyacetone kinase; Provisional; Region: PRK14479
1118963005614	Dak1 domain; Region: Dak1; cl10557
1118963005615	DAK2 domain; Region: Dak2; pfam02734
1118963005616	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1118963005617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005618	putative substrate translocation pore; other site
1118963005619	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1118963005620	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963005621	DNA-binding site [nucleotide binding]; DNA binding site
1118963005622	FCD domain; Region: FCD; pfam07729
1118963005623	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963005624	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963005625	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1118963005626	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963005627	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005628	putative substrate translocation pore; other site
1118963005629	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963005630	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963005631	NAD(P) binding site [chemical binding]; other site
1118963005632	active site
1118963005633	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1118963005634	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1118963005635	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1118963005636	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
1118963005637	active site
1118963005638	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1118963005639	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1118963005640	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1118963005641	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1118963005642	substrate binding site [chemical binding]; other site
1118963005643	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1118963005644	short chain dehydrogenase; Provisional; Region: PRK08263
1118963005645	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1118963005646	NADP binding site [chemical binding]; other site
1118963005647	active site
1118963005648	steroid binding site; other site
1118963005649	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1118963005650	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963005651	enoyl-CoA hydratase; Provisional; Region: PRK06142
1118963005652	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1118963005653	substrate binding site [chemical binding]; other site
1118963005654	oxyanion hole (OAH) forming residues; other site
1118963005655	trimer interface [polypeptide binding]; other site
1118963005656	lipid-transfer protein; Provisional; Region: PRK07855
1118963005657	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1118963005658	active site
1118963005659	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963005660	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963005661	PrpF protein; Region: PrpF; cl19418
1118963005662	aldehyde dehydrogenase family 2 member; Region: PLN02466
1118963005663	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1118963005664	NAD(P) binding site [chemical binding]; other site
1118963005665	catalytic residues [active]
1118963005666	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1118963005667	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1118963005668	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963005669	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963005670	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963005671	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963005672	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1118963005673	classical (c) SDRs; Region: SDR_c; cd05233
1118963005674	NAD(P) binding site [chemical binding]; other site
1118963005675	active site
1118963005676	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1118963005677	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963005678	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963005679	Reductase C-terminal; Region: Reductase_C; pfam14759
1118963005680	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1118963005681	lipid-transfer protein; Provisional; Region: PRK07855
1118963005682	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1118963005683	active site
1118963005684	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
1118963005685	DUF35 OB-fold domain; Region: DUF35; pfam01796
1118963005686	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963005687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963005688	NAD(P) binding site [chemical binding]; other site
1118963005689	active site
1118963005690	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963005691	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
1118963005692	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1118963005693	active site
1118963005694	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
1118963005695	DUF35 OB-fold domain; Region: DUF35; pfam01796
1118963005696	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1118963005697	enoyl-CoA hydratase; Provisional; Region: PRK06494
1118963005698	substrate binding site [chemical binding]; other site
1118963005699	oxyanion hole (OAH) forming residues; other site
1118963005700	trimer interface [polypeptide binding]; other site
1118963005701	Mu-like prophage FluMu protein gp41 [Function unknown]; Region: COG4518
1118963005702	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1118963005703	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1118963005704	Q-loop/lid; other site
1118963005705	ABC transporter signature motif; other site
1118963005706	Walker B; other site
1118963005707	D-loop; other site
1118963005708	H-loop/switch region; other site
1118963005709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005710	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963005711	putative substrate translocation pore; other site
1118963005712	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1118963005713	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1118963005714	Protein of unknown function (DUF1255); Region: DUF1255; cl01202
1118963005715	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963005716	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1118963005717	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963005718	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1118963005719	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
1118963005720	putative metal binding site [ion binding]; other site
1118963005721	Putative cyclase; Region: Cyclase; pfam04199
1118963005722	DctM-like transporters; Region: DctM; pfam06808
1118963005723	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1118963005724	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1118963005725	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
1118963005726	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
1118963005727	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
1118963005728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1118963005729	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
1118963005730	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1118963005731	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963005732	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963005733	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963005734	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963005735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963005736	dimer interface [polypeptide binding]; other site
1118963005737	conserved gate region; other site
1118963005738	putative PBP binding loops; other site
1118963005739	ABC-ATPase subunit interface; other site
1118963005740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963005741	dimer interface [polypeptide binding]; other site
1118963005742	conserved gate region; other site
1118963005743	putative PBP binding loops; other site
1118963005744	ABC-ATPase subunit interface; other site
1118963005745	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1118963005746	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1118963005747	hexamer interface [polypeptide binding]; other site
1118963005748	active site
1118963005749	metal binding site [ion binding]; metal-binding site
1118963005750	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1118963005751	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1118963005752	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963005753	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963005754	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1118963005755	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1118963005756	Walker A/P-loop; other site
1118963005757	ATP binding site [chemical binding]; other site
1118963005758	Q-loop/lid; other site
1118963005759	ABC transporter signature motif; other site
1118963005760	Walker B; other site
1118963005761	D-loop; other site
1118963005762	H-loop/switch region; other site
1118963005763	TOBE domain; Region: TOBE_2; pfam08402
1118963005764	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1118963005765	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1118963005766	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1118963005767	putative active site [active]
1118963005768	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1118963005769	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963005770	Walker A/P-loop; other site
1118963005771	ATP binding site [chemical binding]; other site
1118963005772	Q-loop/lid; other site
1118963005773	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1118963005774	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
1118963005775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963005776	Walker A/P-loop; other site
1118963005777	ATP binding site [chemical binding]; other site
1118963005778	Q-loop/lid; other site
1118963005779	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963005780	Ligand Binding Site [chemical binding]; other site
1118963005781	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1118963005782	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
1118963005783	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
1118963005784	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
1118963005785	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
1118963005786	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
1118963005787	putative NAD(P) binding site [chemical binding]; other site
1118963005788	putative substrate binding site [chemical binding]; other site
1118963005789	catalytic Zn binding site [ion binding]; other site
1118963005790	structural Zn binding site [ion binding]; other site
1118963005791	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963005792	Ligand Binding Site [chemical binding]; other site
1118963005793	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1118963005794	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963005795	Ligand Binding Site [chemical binding]; other site
1118963005796	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963005797	Ligand Binding Site [chemical binding]; other site
1118963005798	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1118963005799	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1118963005800	Beta-Casp domain; Region: Beta-Casp; pfam10996
1118963005801	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
1118963005802	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963005803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963005804	active site
1118963005805	phosphorylation site [posttranslational modification]
1118963005806	intermolecular recognition site; other site
1118963005807	dimerization interface [polypeptide binding]; other site
1118963005808	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963005809	DNA binding residues [nucleotide binding]
1118963005810	dimerization interface [polypeptide binding]; other site
1118963005811	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1118963005812	GAF domain; Region: GAF_3; pfam13492
1118963005813	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1118963005814	Histidine kinase; Region: HisKA_3; pfam07730
1118963005815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963005816	ATP binding site [chemical binding]; other site
1118963005817	Mg2+ binding site [ion binding]; other site
1118963005818	G-X-G motif; other site
1118963005819	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1118963005820	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1118963005821	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1118963005822	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
1118963005823	catalytic Zn binding site [ion binding]; other site
1118963005824	structural Zn binding site [ion binding]; other site
1118963005825	NAD(P) binding site [chemical binding]; other site
1118963005826	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1118963005827	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1118963005828	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1118963005829	phosphate acetyltransferase; Reviewed; Region: PRK05632
1118963005830	DRTGG domain; Region: DRTGG; pfam07085
1118963005831	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1118963005832	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963005833	Ligand Binding Site [chemical binding]; other site
1118963005834	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1118963005835	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1118963005836	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1118963005837	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963005838	Ligand Binding Site [chemical binding]; other site
1118963005839	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963005840	Ligand Binding Site [chemical binding]; other site
1118963005841	Acetokinase family; Region: Acetate_kinase; cl17229
1118963005842	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963005843	putative phosphoketolase; Provisional; Region: PRK05261
1118963005844	XFP N-terminal domain; Region: XFP_N; pfam09364
1118963005845	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1118963005846	XFP C-terminal domain; Region: XFP_C; pfam09363
1118963005847	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1118963005848	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1118963005849	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1118963005850	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963005851	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963005852	putative DNA binding site [nucleotide binding]; other site
1118963005853	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1118963005854	putative dimerization interface [polypeptide binding]; other site
1118963005855	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963005856	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963005857	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963005858	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963005859	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005860	putative substrate translocation pore; other site
1118963005861	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963005862	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1118963005863	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1118963005864	metal binding site [ion binding]; metal-binding site
1118963005865	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1118963005866	classical (c) SDRs; Region: SDR_c; cd05233
1118963005867	NAD(P) binding site [chemical binding]; other site
1118963005868	active site
1118963005869	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963005870	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963005871	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005872	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963005873	putative substrate translocation pore; other site
1118963005874	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1118963005875	AAA domain; Region: AAA_17; cl19128
1118963005876	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1118963005877	Entner-Doudoroff aldolase; Region: eda; TIGR01182
1118963005878	active site
1118963005879	intersubunit interface [polypeptide binding]; other site
1118963005880	catalytic residue [active]
1118963005881	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963005882	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
1118963005883	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963005884	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963005885	DNA binding site [nucleotide binding]
1118963005886	domain linker motif; other site
1118963005887	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963005888	dimerization interface [polypeptide binding]; other site
1118963005889	ligand binding site [chemical binding]; other site
1118963005890	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1118963005891	active site
1118963005892	metal binding site [ion binding]; metal-binding site
1118963005893	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963005894	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963005895	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1118963005896	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963005897	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963005898	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963005899	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1118963005900	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963005901	putative substrate translocation pore; other site
1118963005902	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963005903	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
1118963005904	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963005905	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963005906	classical (c) SDRs; Region: SDR_c; cd05233
1118963005907	NAD(P) binding site [chemical binding]; other site
1118963005908	active site
1118963005909	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963005910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963005911	dimer interface [polypeptide binding]; other site
1118963005912	conserved gate region; other site
1118963005913	putative PBP binding loops; other site
1118963005914	ABC-ATPase subunit interface; other site
1118963005915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963005916	dimer interface [polypeptide binding]; other site
1118963005917	conserved gate region; other site
1118963005918	putative PBP binding loops; other site
1118963005919	ABC-ATPase subunit interface; other site
1118963005920	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963005921	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963005922	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
1118963005923	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1118963005924	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1118963005925	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1118963005926	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1118963005927	substrate binding site [chemical binding]; other site
1118963005928	THF binding site; other site
1118963005929	zinc-binding site [ion binding]; other site
1118963005930	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
1118963005931	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963005932	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963005933	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963005934	dimerization interface [polypeptide binding]; other site
1118963005935	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963005936	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963005937	active site
1118963005938	catalytic tetrad [active]
1118963005939	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
1118963005940	hydroperoxidase II; Provisional; Region: katE; PRK11249
1118963005941	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1118963005942	heme binding pocket [chemical binding]; other site
1118963005943	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1118963005944	domain interactions; other site
1118963005945	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1118963005946	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1118963005947	NAD binding site [chemical binding]; other site
1118963005948	catalytic Zn binding site [ion binding]; other site
1118963005949	structural Zn binding site [ion binding]; other site
1118963005950	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
1118963005951	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
1118963005952	NAD binding site [chemical binding]; other site
1118963005953	catalytic Zn binding site [ion binding]; other site
1118963005954	structural Zn binding site [ion binding]; other site
1118963005955	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1118963005956	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1118963005957	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1118963005958	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1118963005959	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1118963005960	ligand binding site [chemical binding]; other site
1118963005961	flexible hinge region; other site
1118963005962	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1118963005963	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963005964	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963005965	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1118963005966	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1118963005967	nucleotide binding site [chemical binding]; other site
1118963005968	NEF interaction site [polypeptide binding]; other site
1118963005969	SBD interface [polypeptide binding]; other site
1118963005970	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1118963005971	dimer interface [polypeptide binding]; other site
1118963005972	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1118963005973	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
1118963005974	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1118963005975	HSP70 interaction site [polypeptide binding]; other site
1118963005976	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1118963005977	substrate binding site [polypeptide binding]; other site
1118963005978	dimer interface [polypeptide binding]; other site
1118963005979	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1118963005980	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1118963005981	Clp amino terminal domain; Region: Clp_N; pfam02861
1118963005982	Clp amino terminal domain; Region: Clp_N; pfam02861
1118963005983	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963005984	Walker A motif; other site
1118963005985	ATP binding site [chemical binding]; other site
1118963005986	Walker B motif; other site
1118963005987	arginine finger; other site
1118963005988	Centrosome localisation domain of PPC89; Region: Cep57_CLD_2; pfam14197
1118963005989	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963005990	Walker A motif; other site
1118963005991	ATP binding site [chemical binding]; other site
1118963005992	Walker B motif; other site
1118963005993	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1118963005994	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
1118963005995	thioredoxin 2; Provisional; Region: PRK10996
1118963005996	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1118963005997	catalytic residues [active]
1118963005998	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1118963005999	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1118963006000	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1118963006001	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963006002	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1118963006003	nucleotide binding site [chemical binding]; other site
1118963006004	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963006005	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963006006	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963006007	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963006008	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963006009	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963006010	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1118963006011	TM-ABC transporter signature motif; other site
1118963006012	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1118963006013	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1118963006014	ligand binding site [chemical binding]; other site
1118963006015	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963006016	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963006017	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963006018	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963006019	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1118963006020	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1118963006021	Walker A/P-loop; other site
1118963006022	ATP binding site [chemical binding]; other site
1118963006023	Q-loop/lid; other site
1118963006024	ABC transporter signature motif; other site
1118963006025	Walker B; other site
1118963006026	D-loop; other site
1118963006027	H-loop/switch region; other site
1118963006028	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1118963006029	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963006030	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963006031	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1118963006032	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1118963006033	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1118963006034	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1118963006035	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1118963006036	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1118963006037	Fic/DOC family; Region: Fic; cl00960
1118963006038	AraC-binding-like domain; Region: AraC_binding_2; pfam14525
1118963006039	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1118963006040	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963006041	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
1118963006042	putative active site [active]
1118963006043	catalytic triad [active]
1118963006044	putative dimer interface [polypeptide binding]; other site
1118963006045	Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816
1118963006046	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1118963006047	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1118963006048	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1118963006049	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
1118963006050	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1118963006051	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1118963006052	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1118963006053	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1118963006054	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1118963006055	NAD(P) binding site [chemical binding]; other site
1118963006056	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1118963006057	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
1118963006058	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
1118963006059	dimer interface [polypeptide binding]; other site
1118963006060	catalytic residue [active]
1118963006061	metal binding site [ion binding]; metal-binding site
1118963006062	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
1118963006063	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1118963006064	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963006065	DNA-binding site [nucleotide binding]; DNA binding site
1118963006066	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1118963006067	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1118963006068	Domain of unknown function DUF11; Region: DUF11; cl17728
1118963006069	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1118963006070	Cna protein B-type domain; Region: Cna_B; pfam05738
1118963006071	Cna protein B-type domain; Region: Cna_B; pfam05738
1118963006072	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1118963006073	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1118963006074	active site
1118963006075	catalytic site [active]
1118963006076	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1118963006077	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963006078	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1118963006079	DNA binding residues [nucleotide binding]
1118963006080	Putative zinc-finger; Region: zf-HC2; pfam13490
1118963006081	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1118963006082	transketolase; Reviewed; Region: PRK05899
1118963006083	TPP-binding site [chemical binding]; other site
1118963006084	PYR/PP interface [polypeptide binding]; other site
1118963006085	dimer interface [polypeptide binding]; other site
1118963006086	TPP binding site [chemical binding]; other site
1118963006087	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
1118963006088	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1118963006089	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963006090	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1118963006091	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963006092	active site
1118963006093	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
1118963006094	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
1118963006095	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963006096	catalytic residue [active]
1118963006097	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1118963006098	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963006099	Walker A/P-loop; other site
1118963006100	ATP binding site [chemical binding]; other site
1118963006101	Q-loop/lid; other site
1118963006102	ABC transporter signature motif; other site
1118963006103	Walker B; other site
1118963006104	D-loop; other site
1118963006105	H-loop/switch region; other site
1118963006106	TOBE domain; Region: TOBE_2; pfam08402
1118963006107	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1118963006108	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963006109	dimer interface [polypeptide binding]; other site
1118963006110	conserved gate region; other site
1118963006111	putative PBP binding loops; other site
1118963006112	ABC-ATPase subunit interface; other site
1118963006113	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963006114	dimer interface [polypeptide binding]; other site
1118963006115	conserved gate region; other site
1118963006116	putative PBP binding loops; other site
1118963006117	ABC-ATPase subunit interface; other site
1118963006118	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1118963006119	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963006120	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963006121	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963006122	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963006123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963006124	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963006125	putative substrate translocation pore; other site
1118963006126	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1118963006127	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1118963006128	FAD binding domain; Region: FAD_binding_4; cl19922
1118963006129	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1118963006130	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1118963006131	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1118963006132	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1118963006133	catalytic loop [active]
1118963006134	iron binding site [ion binding]; other site
1118963006135	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1118963006136	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1118963006137	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1118963006138	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1118963006139	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1118963006140	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1118963006141	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1118963006142	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
1118963006143	NAD(P) binding site [chemical binding]; other site
1118963006144	catalytic residues [active]
1118963006145	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1118963006146	homotrimer interaction site [polypeptide binding]; other site
1118963006147	putative active site [active]
1118963006148	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1118963006149	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1118963006150	FMN-binding pocket [chemical binding]; other site
1118963006151	flavin binding motif; other site
1118963006152	phosphate binding motif [ion binding]; other site
1118963006153	beta-alpha-beta structure motif; other site
1118963006154	NAD binding pocket [chemical binding]; other site
1118963006155	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1118963006156	catalytic loop [active]
1118963006157	iron binding site [ion binding]; other site
1118963006158	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1118963006159	active site
1118963006160	metal binding site [ion binding]; metal-binding site
1118963006161	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
1118963006162	C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239
1118963006163	putative active site [active]
1118963006164	Mn binding site [ion binding]; other site
1118963006165	putative oligomer interface [polypeptide binding]; other site
1118963006166	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963006167	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963006168	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963006169	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1118963006170	classical (c) SDRs; Region: SDR_c; cd05233
1118963006171	NAD(P) binding site [chemical binding]; other site
1118963006172	active site
1118963006173	short chain dehydrogenase; Provisional; Region: PRK07062
1118963006174	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963006175	NAD(P) binding site [chemical binding]; other site
1118963006176	active site
1118963006177	hypothetical protein; Provisional; Region: PRK07064
1118963006178	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1118963006179	PYR/PP interface [polypeptide binding]; other site
1118963006180	dimer interface [polypeptide binding]; other site
1118963006181	TPP binding site [chemical binding]; other site
1118963006182	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1118963006183	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1118963006184	TPP-binding site [chemical binding]; other site
1118963006185	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963006186	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1118963006187	iron-sulfur cluster [ion binding]; other site
1118963006188	[2Fe-2S] cluster binding site [ion binding]; other site
1118963006189	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1118963006190	hydrophobic ligand binding site; other site
1118963006191	Cupin domain; Region: Cupin_2; pfam07883
1118963006192	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963006193	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1118963006194	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1118963006195	Domain of unknown function DUF108; Region: DUF108; pfam01958
1118963006196	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1118963006197	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1118963006198	inhibitor-cofactor binding pocket; inhibition site
1118963006199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963006200	catalytic residue [active]
1118963006201	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1118963006202	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1118963006203	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1118963006204	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1118963006205	tetrameric interface [polypeptide binding]; other site
1118963006206	NAD binding site [chemical binding]; other site
1118963006207	catalytic residues [active]
1118963006208	mycothione reductase; Region: mycothione_red; TIGR03452
1118963006209	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963006210	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963006211	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1118963006212	conserved hypothetical protein; Region: TIGR03843
1118963006213	conserved hypothetical protein; Region: TIGR03847
1118963006214	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1118963006215	catalytic core [active]
1118963006216	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963006217	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1118963006218	Walker A motif; other site
1118963006219	ATP binding site [chemical binding]; other site
1118963006220	Walker B motif; other site
1118963006221	arginine finger; other site
1118963006222	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1118963006223	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1118963006224	dimerization interface [polypeptide binding]; other site
1118963006225	ligand binding site [chemical binding]; other site
1118963006226	NADP binding site [chemical binding]; other site
1118963006227	catalytic site [active]
1118963006228	aspartate aminotransferase; Provisional; Region: PRK05764
1118963006229	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963006230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963006231	homodimer interface [polypeptide binding]; other site
1118963006232	catalytic residue [active]
1118963006233	Protein of unknown function (DUF808); Region: DUF808; cl01002
1118963006234	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1118963006235	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1118963006236	potential catalytic triad [active]
1118963006237	conserved cys residue [active]
1118963006238	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963006239	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963006240	DNA binding site [nucleotide binding]
1118963006241	domain linker motif; other site
1118963006242	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
1118963006243	putative dimerization interface [polypeptide binding]; other site
1118963006244	putative ligand binding site [chemical binding]; other site
1118963006245	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1118963006246	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
1118963006247	substrate binding site [chemical binding]; other site
1118963006248	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1118963006249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963006250	dimer interface [polypeptide binding]; other site
1118963006251	conserved gate region; other site
1118963006252	putative PBP binding loops; other site
1118963006253	ABC-ATPase subunit interface; other site
1118963006254	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1118963006255	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1118963006256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963006257	dimer interface [polypeptide binding]; other site
1118963006258	conserved gate region; other site
1118963006259	putative PBP binding loops; other site
1118963006260	ABC-ATPase subunit interface; other site
1118963006261	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1118963006262	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963006263	Walker A/P-loop; other site
1118963006264	ATP binding site [chemical binding]; other site
1118963006265	Q-loop/lid; other site
1118963006266	ABC transporter signature motif; other site
1118963006267	Walker B; other site
1118963006268	D-loop; other site
1118963006269	H-loop/switch region; other site
1118963006270	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1118963006271	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1118963006272	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963006273	Walker A/P-loop; other site
1118963006274	ATP binding site [chemical binding]; other site
1118963006275	Q-loop/lid; other site
1118963006276	ABC transporter signature motif; other site
1118963006277	Walker B; other site
1118963006278	D-loop; other site
1118963006279	H-loop/switch region; other site
1118963006280	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1118963006281	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1118963006282	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1118963006283	substrate binding [chemical binding]; other site
1118963006284	active site
1118963006285	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1118963006286	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
1118963006287	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1118963006288	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1118963006289	substrate binding [chemical binding]; other site
1118963006290	active site
1118963006291	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1118963006292	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1118963006293	putative substrate binding site [chemical binding]; other site
1118963006294	putative ATP binding site [chemical binding]; other site
1118963006295	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1118963006296	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963006297	Walker A/P-loop; other site
1118963006298	ATP binding site [chemical binding]; other site
1118963006299	Q-loop/lid; other site
1118963006300	ABC transporter signature motif; other site
1118963006301	Walker B; other site
1118963006302	D-loop; other site
1118963006303	H-loop/switch region; other site
1118963006304	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1118963006305	ABC-ATPase subunit  interface; other site
1118963006306	dimer interface [polypeptide binding]; other site
1118963006307	putative PBP binding regions; other site
1118963006308	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1118963006309	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1118963006310	intersubunit interface [polypeptide binding]; other site
1118963006311	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
1118963006312	Citrate transporter; Region: CitMHS; pfam03600
1118963006313	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1118963006314	transmembrane helices; other site
1118963006315	PrpF protein; Region: PrpF; cl19418
1118963006316	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963006317	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963006318	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1118963006319	putative dimerization interface [polypeptide binding]; other site
1118963006320	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1118963006321	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963006322	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963006323	dimerization interface [polypeptide binding]; other site
1118963006324	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
1118963006325	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
1118963006326	acyl-activating enzyme (AAE) consensus motif; other site
1118963006327	putative AMP binding site [chemical binding]; other site
1118963006328	putative active site [active]
1118963006329	putative CoA binding site [chemical binding]; other site
1118963006330	thiolase; Provisional; Region: PRK06158
1118963006331	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1118963006332	active site
1118963006333	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963006334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963006335	putative substrate translocation pore; other site
1118963006336	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1118963006337	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1118963006338	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1118963006339	dimer interface [polypeptide binding]; other site
1118963006340	PYR/PP interface [polypeptide binding]; other site
1118963006341	TPP binding site [chemical binding]; other site
1118963006342	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1118963006343	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1118963006344	TPP-binding site [chemical binding]; other site
1118963006345	N-terminal domain of (some) glycogen debranching enzymes; Region: GDE_N_bis; pfam14742
1118963006346	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1118963006347	Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168
1118963006348	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
1118963006349	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1118963006350	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963006351	DNA-binding site [nucleotide binding]; DNA binding site
1118963006352	FCD domain; Region: FCD; pfam07729
1118963006353	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1118963006354	tetramerization interface [polypeptide binding]; other site
1118963006355	NAD(P) binding site [chemical binding]; other site
1118963006356	catalytic residues [active]
1118963006357	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1118963006358	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1118963006359	inhibitor-cofactor binding pocket; inhibition site
1118963006360	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963006361	catalytic residue [active]
1118963006362	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963006363	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1118963006364	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1118963006365	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1118963006366	Walker A/P-loop; other site
1118963006367	ATP binding site [chemical binding]; other site
1118963006368	Q-loop/lid; other site
1118963006369	ABC transporter signature motif; other site
1118963006370	Walker B; other site
1118963006371	D-loop; other site
1118963006372	H-loop/switch region; other site
1118963006373	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1118963006374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963006375	dimer interface [polypeptide binding]; other site
1118963006376	conserved gate region; other site
1118963006377	putative PBP binding loops; other site
1118963006378	ABC-ATPase subunit interface; other site
1118963006379	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1118963006380	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1118963006381	substrate binding pocket [chemical binding]; other site
1118963006382	membrane-bound complex binding site; other site
1118963006383	hinge residues; other site
1118963006384	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1118963006385	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
1118963006386	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1118963006387	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1118963006388	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1118963006389	NAD(P) binding site [chemical binding]; other site
1118963006390	catalytic residues [active]
1118963006391	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1118963006392	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
1118963006393	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1118963006394	NAD binding site [chemical binding]; other site
1118963006395	ligand binding site [chemical binding]; other site
1118963006396	catalytic site [active]
1118963006397	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1118963006398	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1118963006399	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1118963006400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963006401	dimer interface [polypeptide binding]; other site
1118963006402	conserved gate region; other site
1118963006403	putative PBP binding loops; other site
1118963006404	ABC-ATPase subunit interface; other site
1118963006405	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
1118963006406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963006407	dimer interface [polypeptide binding]; other site
1118963006408	conserved gate region; other site
1118963006409	putative PBP binding loops; other site
1118963006410	ABC-ATPase subunit interface; other site
1118963006411	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1118963006412	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963006413	Walker A/P-loop; other site
1118963006414	ATP binding site [chemical binding]; other site
1118963006415	Q-loop/lid; other site
1118963006416	ABC transporter signature motif; other site
1118963006417	Walker B; other site
1118963006418	D-loop; other site
1118963006419	H-loop/switch region; other site
1118963006420	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1118963006421	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963006422	Walker A/P-loop; other site
1118963006423	ATP binding site [chemical binding]; other site
1118963006424	Q-loop/lid; other site
1118963006425	ABC transporter signature motif; other site
1118963006426	Walker B; other site
1118963006427	D-loop; other site
1118963006428	H-loop/switch region; other site
1118963006429	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1118963006430	putative di-iron ligands [ion binding]; other site
1118963006431	GAF domain; Region: GAF_2; pfam13185
1118963006432	ANTAR domain; Region: ANTAR; pfam03861
1118963006433	GAF domain; Region: GAF; cl17456
1118963006434	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1118963006435	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1118963006436	Tautomerase enzyme; Region: Tautomerase_2; pfam14552
1118963006437	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1118963006438	substrate binding site [chemical binding]; other site
1118963006439	ATP binding site [chemical binding]; other site
1118963006440	Class I aldolases; Region: Aldolase_Class_I; cl17187
1118963006441	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1118963006442	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1118963006443	PYR/PP interface [polypeptide binding]; other site
1118963006444	dimer interface [polypeptide binding]; other site
1118963006445	TPP binding site [chemical binding]; other site
1118963006446	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1118963006447	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1118963006448	TPP-binding site [chemical binding]; other site
1118963006449	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1118963006450	tetrameric interface [polypeptide binding]; other site
1118963006451	NAD binding site [chemical binding]; other site
1118963006452	catalytic residues [active]
1118963006453	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963006454	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963006455	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963006456	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963006457	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963006458	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963006459	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963006460	putative oxidoreductase; Provisional; Region: PRK11579
1118963006461	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963006462	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963006463	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963006464	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963006465	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963006466	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963006467	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963006468	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963006469	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963006470	DNA binding site [nucleotide binding]
1118963006471	domain linker motif; other site
1118963006472	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963006473	ligand binding site [chemical binding]; other site
1118963006474	dimerization interface [polypeptide binding]; other site
1118963006475	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
1118963006476	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1118963006477	putative ligand binding site [chemical binding]; other site
1118963006478	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1118963006479	TM-ABC transporter signature motif; other site
1118963006480	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1118963006481	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1118963006482	Walker A/P-loop; other site
1118963006483	ATP binding site [chemical binding]; other site
1118963006484	Q-loop/lid; other site
1118963006485	ABC transporter signature motif; other site
1118963006486	Walker B; other site
1118963006487	D-loop; other site
1118963006488	H-loop/switch region; other site
1118963006489	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963006490	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963006491	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963006492	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963006493	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963006494	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963006495	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963006496	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963006497	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963006498	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963006499	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963006500	KduI/IolB family; Region: KduI; pfam04962
1118963006501	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1118963006502	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963006503	DNA-binding site [nucleotide binding]; DNA binding site
1118963006504	UTRA domain; Region: UTRA; pfam07702
1118963006505	ChaB; Region: ChaB; pfam06150
1118963006506	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
1118963006507	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1118963006508	dimer interface [polypeptide binding]; other site
1118963006509	active site
1118963006510	CoA binding pocket [chemical binding]; other site
1118963006511	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963006512	peptide synthase; Provisional; Region: PRK09274
1118963006513	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
1118963006514	acyl-activating enzyme (AAE) consensus motif; other site
1118963006515	putative AMP binding site [chemical binding]; other site
1118963006516	putative active site [active]
1118963006517	putative CoA binding site [chemical binding]; other site
1118963006518	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963006519	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963006520	NAD(P) binding site [chemical binding]; other site
1118963006521	active site
1118963006522	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963006523	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963006524	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1118963006525	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
1118963006526	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1118963006527	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1118963006528	DNA-binding site [nucleotide binding]; DNA binding site
1118963006529	RNA-binding motif; other site
1118963006530	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1118963006531	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
1118963006532	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
1118963006533	nucleotide binding site [chemical binding]; other site
1118963006534	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
1118963006535	pyruvate dehydrogenase; Provisional; Region: PRK06546
1118963006536	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1118963006537	PYR/PP interface [polypeptide binding]; other site
1118963006538	dimer interface [polypeptide binding]; other site
1118963006539	tetramer interface [polypeptide binding]; other site
1118963006540	TPP binding site [chemical binding]; other site
1118963006541	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1118963006542	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1118963006543	TPP-binding site [chemical binding]; other site
1118963006544	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1118963006545	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963006546	Walker A/P-loop; other site
1118963006547	ATP binding site [chemical binding]; other site
1118963006548	Q-loop/lid; other site
1118963006549	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963006550	ABC transporter signature motif; other site
1118963006551	Walker B; other site
1118963006552	D-loop; other site
1118963006553	H-loop/switch region; other site
1118963006554	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963006555	Walker A/P-loop; other site
1118963006556	ATP binding site [chemical binding]; other site
1118963006557	Q-loop/lid; other site
1118963006558	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048
1118963006559	ABC transporter signature motif; other site
1118963006560	Walker B; other site
1118963006561	D-loop; other site
1118963006562	H-loop/switch region; other site
1118963006563	SnoaL-like domain; Region: SnoaL_2; pfam12680
1118963006564	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1118963006565	homotrimer interaction site [polypeptide binding]; other site
1118963006566	putative active site [active]
1118963006567	hypothetical protein; Provisional; Region: PRK09256
1118963006568	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1118963006569	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1118963006570	Walker A/P-loop; other site
1118963006571	ATP binding site [chemical binding]; other site
1118963006572	Q-loop/lid; other site
1118963006573	ABC transporter signature motif; other site
1118963006574	Walker B; other site
1118963006575	D-loop; other site
1118963006576	H-loop/switch region; other site
1118963006577	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1118963006578	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1118963006579	siderophore binding site; other site
1118963006580	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1118963006581	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1118963006582	ABC-ATPase subunit  interface; other site
1118963006583	dimer interface [polypeptide binding]; other site
1118963006584	putative PBP binding regions; other site
1118963006585	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1118963006586	ABC-ATPase subunit  interface; other site
1118963006587	dimer interface [polypeptide binding]; other site
1118963006588	putative PBP binding regions; other site
1118963006589	putative ATPase RIL; Provisional; Region: PRK13409
1118963006590	RibD C-terminal domain; Region: RibD_C; cl17279
1118963006591	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1118963006592	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1118963006593	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1118963006594	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1118963006595	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1118963006596	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1118963006597	NADP+ binding site [chemical binding]; other site
1118963006598	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963006599	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963006600	putative substrate translocation pore; other site
1118963006601	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
1118963006602	metal ion-dependent adhesion site (MIDAS); other site
1118963006603	MoxR-like ATPases [General function prediction only]; Region: COG0714
1118963006604	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963006605	Walker A motif; other site
1118963006606	ATP binding site [chemical binding]; other site
1118963006607	Walker B motif; other site
1118963006608	arginine finger; other site
1118963006609	SWIM zinc finger; Region: SWIM; pfam04434
1118963006610	phenol 2-monooxygenase; Provisional; Region: PRK08294
1118963006611	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963006612	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
1118963006613	dimer interface [polypeptide binding]; other site
1118963006614	5'-3' exonuclease; Region: 53EXOc; smart00475
1118963006615	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1118963006616	active site
1118963006617	metal binding site 1 [ion binding]; metal-binding site
1118963006618	putative 5' ssDNA interaction site; other site
1118963006619	metal binding site 3; metal-binding site
1118963006620	metal binding site 2 [ion binding]; metal-binding site
1118963006621	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1118963006622	putative DNA binding site [nucleotide binding]; other site
1118963006623	putative metal binding site [ion binding]; other site
1118963006624	YCII-related domain; Region: YCII; cl00999
1118963006625	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1118963006626	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963006627	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1118963006628	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1118963006629	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1118963006630	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963006631	active site
1118963006632	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963006633	salt bridge; other site
1118963006634	non-specific DNA binding site [nucleotide binding]; other site
1118963006635	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1118963006636	sequence-specific DNA binding site [nucleotide binding]; other site
1118963006637	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1118963006638	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1118963006639	putative NAD(P) binding site [chemical binding]; other site
1118963006640	putative substrate binding site [chemical binding]; other site
1118963006641	catalytic Zn binding site [ion binding]; other site
1118963006642	structural Zn binding site [ion binding]; other site
1118963006643	dimer interface [polypeptide binding]; other site
1118963006644	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
1118963006645	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963006646	ATP binding site [chemical binding]; other site
1118963006647	putative Mg++ binding site [ion binding]; other site
1118963006648	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963006649	nucleotide binding region [chemical binding]; other site
1118963006650	ATP-binding site [chemical binding]; other site
1118963006651	Helicase associated domain (HA2); Region: HA2; pfam04408
1118963006652	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1118963006653	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1118963006654	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1118963006655	active site
1118963006656	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963006657	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1118963006658	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963006659	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1118963006660	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1118963006661	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1118963006662	elongation factor G; Reviewed; Region: PRK12740
1118963006663	G1 box; other site
1118963006664	GTP/Mg2+ binding site [chemical binding]; other site
1118963006665	G2 box; other site
1118963006666	Switch I region; other site
1118963006667	G3 box; other site
1118963006668	Switch II region; other site
1118963006669	G4 box; other site
1118963006670	G5 box; other site
1118963006671	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1118963006672	Elongation Factor G, domain II; Region: EFG_II; pfam14492
1118963006673	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1118963006674	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1118963006675	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963006676	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1118963006677	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
1118963006678	nucleotide binding site [chemical binding]; other site
1118963006679	Beta-lactamase; Region: Beta-lactamase; pfam00144
1118963006680	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1118963006681	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1118963006682	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1118963006683	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963006684	Walker A/P-loop; other site
1118963006685	ATP binding site [chemical binding]; other site
1118963006686	Q-loop/lid; other site
1118963006687	ABC transporter signature motif; other site
1118963006688	Walker B; other site
1118963006689	D-loop; other site
1118963006690	H-loop/switch region; other site
1118963006691	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192
1118963006692	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1118963006693	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1118963006694	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1118963006695	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963006696	DNA-binding site [nucleotide binding]; DNA binding site
1118963006697	UTRA domain; Region: UTRA; pfam07702
1118963006698	Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327
1118963006699	PaaX-like protein; Region: PaaX; pfam07848
1118963006700	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1118963006701	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
1118963006702	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963006703	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963006704	catalytic residue [active]
1118963006705	catalytic residue [active]
1118963006706	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
1118963006707	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1118963006708	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1118963006709	NADP+ binding site [chemical binding]; other site
1118963006710	folate binding site [chemical binding]; other site
1118963006711	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1118963006712	CoenzymeA binding site [chemical binding]; other site
1118963006713	subunit interaction site [polypeptide binding]; other site
1118963006714	PHB binding site; other site
1118963006715	DNA polymerase I; Provisional; Region: PRK05755
1118963006716	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1118963006717	active site
1118963006718	putative 5' ssDNA interaction site; other site
1118963006719	metal binding site 3; metal-binding site
1118963006720	metal binding site 1 [ion binding]; metal-binding site
1118963006721	metal binding site 2 [ion binding]; metal-binding site
1118963006722	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1118963006723	putative DNA binding site [nucleotide binding]; other site
1118963006724	putative metal binding site [ion binding]; other site
1118963006725	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1118963006726	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1118963006727	active site
1118963006728	DNA binding site [nucleotide binding]
1118963006729	catalytic site [active]
1118963006730	hypothetical protein; Provisional; Region: PRK01346
1118963006731	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
1118963006732	Sterol carrier protein domain; Region: SCP2_2; pfam13530
1118963006733	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1118963006734	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1118963006735	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
1118963006736	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1118963006737	RNA binding site [nucleotide binding]; other site
1118963006738	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1118963006739	RNA binding site [nucleotide binding]; other site
1118963006740	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1118963006741	RNA binding site [nucleotide binding]; other site
1118963006742	S1 RNA binding domain; Region: S1; pfam00575
1118963006743	RNA binding site [nucleotide binding]; other site
1118963006744	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1118963006745	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1118963006746	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1118963006747	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
1118963006748	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1118963006749	CoA-binding site [chemical binding]; other site
1118963006750	ATP-binding [chemical binding]; other site
1118963006751	GrpB protein; Region: GrpB; pfam04229
1118963006752	excinuclease ABC subunit B; Provisional; Region: PRK05298
1118963006753	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963006754	ATP binding site [chemical binding]; other site
1118963006755	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963006756	nucleotide binding region [chemical binding]; other site
1118963006757	ATP-binding site [chemical binding]; other site
1118963006758	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1118963006759	UvrB/uvrC motif; Region: UVR; pfam02151
1118963006760	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1118963006761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963006762	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963006763	putative substrate translocation pore; other site
1118963006764	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963006765	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1118963006766	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963006767	Coenzyme A binding pocket [chemical binding]; other site
1118963006768	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963006769	ATP binding site [chemical binding]; other site
1118963006770	putative Mg++ binding site [ion binding]; other site
1118963006771	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963006772	nucleotide binding region [chemical binding]; other site
1118963006773	ATP-binding site [chemical binding]; other site
1118963006774	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
1118963006775	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1118963006776	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963006777	S-adenosylmethionine binding site [chemical binding]; other site
1118963006778	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963006779	DNA-binding site [nucleotide binding]; DNA binding site
1118963006780	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1118963006781	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1118963006782	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1118963006783	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1118963006784	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1118963006785	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963006786	active site
1118963006787	motif I; other site
1118963006788	motif II; other site
1118963006789	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1118963006790	putative acyl-acceptor binding pocket; other site
1118963006791	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1118963006792	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1118963006793	GIY-YIG motif/motif A; other site
1118963006794	active site
1118963006795	catalytic site [active]
1118963006796	putative DNA binding site [nucleotide binding]; other site
1118963006797	metal binding site [ion binding]; metal-binding site
1118963006798	UvrB/uvrC motif; Region: UVR; pfam02151
1118963006799	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1118963006800	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
1118963006801	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1118963006802	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1118963006803	phosphate binding site [ion binding]; other site
1118963006804	putative substrate binding pocket [chemical binding]; other site
1118963006805	dimer interface [polypeptide binding]; other site
1118963006806	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1118963006807	WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298
1118963006808	WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527
1118963006809	WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650
1118963006810	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1118963006811	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1118963006812	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1118963006813	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1118963006814	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1118963006815	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1118963006816	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1118963006817	substrate binding site [chemical binding]; other site
1118963006818	hinge regions; other site
1118963006819	ADP binding site [chemical binding]; other site
1118963006820	catalytic site [active]
1118963006821	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1118963006822	substrate binding site [chemical binding]; other site
1118963006823	dimer interface [polypeptide binding]; other site
1118963006824	catalytic triad [active]
1118963006825	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1118963006826	putative active site [active]
1118963006827	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
1118963006828	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
1118963006829	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1118963006830	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1118963006831	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1118963006832	Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: Pgi; COG0166
1118963006833	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1118963006834	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1118963006835	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1118963006836	putative active site [active]
1118963006837	catalytic residue [active]
1118963006838	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1118963006839	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1118963006840	TPP-binding site [chemical binding]; other site
1118963006841	dimer interface [polypeptide binding]; other site
1118963006842	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1118963006843	PYR/PP interface [polypeptide binding]; other site
1118963006844	dimer interface [polypeptide binding]; other site
1118963006845	TPP binding site [chemical binding]; other site
1118963006846	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1118963006847	Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957
1118963006848	putative active site [active]
1118963006849	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1118963006850	active site
1118963006851	metal binding site [ion binding]; metal-binding site
1118963006852	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1118963006853	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1118963006854	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1118963006855	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1118963006856	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1118963006857	Walker A/P-loop; other site
1118963006858	ATP binding site [chemical binding]; other site
1118963006859	Q-loop/lid; other site
1118963006860	ABC transporter signature motif; other site
1118963006861	Walker B; other site
1118963006862	D-loop; other site
1118963006863	H-loop/switch region; other site
1118963006864	Predicted transcriptional regulator [Transcription]; Region: COG2345
1118963006865	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963006866	putative DNA binding site [nucleotide binding]; other site
1118963006867	putative Zn2+ binding site [ion binding]; other site
1118963006868	FeS assembly protein SufB; Region: sufB; TIGR01980
1118963006869	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1118963006870	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1118963006871	FeS assembly protein SufD; Region: sufD; TIGR01981
1118963006872	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1118963006873	[2Fe-2S] cluster binding site [ion binding]; other site
1118963006874	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1118963006875	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1118963006876	Walker A/P-loop; other site
1118963006877	ATP binding site [chemical binding]; other site
1118963006878	Q-loop/lid; other site
1118963006879	ABC transporter signature motif; other site
1118963006880	Walker B; other site
1118963006881	D-loop; other site
1118963006882	H-loop/switch region; other site
1118963006883	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1118963006884	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825
1118963006885	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1118963006886	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1118963006887	AMP binding site [chemical binding]; other site
1118963006888	active site
1118963006889	acyl-activating enzyme (AAE) consensus motif; other site
1118963006890	CoA binding site [chemical binding]; other site
1118963006891	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1118963006892	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
1118963006893	dimer interface [polypeptide binding]; other site
1118963006894	active site
1118963006895	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1118963006896	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1118963006897	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1118963006898	Walker A/P-loop; other site
1118963006899	ATP binding site [chemical binding]; other site
1118963006900	Q-loop/lid; other site
1118963006901	ABC transporter signature motif; other site
1118963006902	Walker B; other site
1118963006903	D-loop; other site
1118963006904	H-loop/switch region; other site
1118963006905	BioY family; Region: BioY; pfam02632
1118963006906	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1118963006907	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963006908	ABC transporter; Region: ABC_tran_2; pfam12848
1118963006909	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963006910	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1118963006911	putative deacylase active site [active]
1118963006912	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1118963006913	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
1118963006914	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1118963006915	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1118963006916	NAD(P) binding site [chemical binding]; other site
1118963006917	homotetramer interface [polypeptide binding]; other site
1118963006918	homodimer interface [polypeptide binding]; other site
1118963006919	active site
1118963006920	short chain dehydrogenase; Provisional; Region: PRK07806
1118963006921	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
1118963006922	NAD(P) binding site [chemical binding]; other site
1118963006923	active site
1118963006924	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1118963006925	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963006926	Walker A/P-loop; other site
1118963006927	ATP binding site [chemical binding]; other site
1118963006928	Q-loop/lid; other site
1118963006929	ABC transporter signature motif; other site
1118963006930	Walker B; other site
1118963006931	D-loop; other site
1118963006932	H-loop/switch region; other site
1118963006933	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1118963006934	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1118963006935	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963006936	motif II; other site
1118963006937	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1118963006938	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1118963006939	Walker A/P-loop; other site
1118963006940	ATP binding site [chemical binding]; other site
1118963006941	Q-loop/lid; other site
1118963006942	ABC transporter signature motif; other site
1118963006943	Walker B; other site
1118963006944	D-loop; other site
1118963006945	H-loop/switch region; other site
1118963006946	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1118963006947	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1118963006948	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1118963006949	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1118963006950	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1118963006951	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1118963006952	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
1118963006953	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
1118963006954	Zn binding site [ion binding]; other site
1118963006955	ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838
1118963006956	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
1118963006957	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1118963006958	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1118963006959	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1118963006960	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1118963006961	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1118963006962	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963006963	NAD(P) binding site [chemical binding]; other site
1118963006964	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963006965	active site
1118963006966	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
1118963006967	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1118963006968	ligand binding site; other site
1118963006969	oligomer interface; other site
1118963006970	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1118963006971	dimer interface [polypeptide binding]; other site
1118963006972	N-terminal domain interface [polypeptide binding]; other site
1118963006973	sulfate 1 binding site; other site
1118963006974	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1118963006975	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1118963006976	acyl-coenzyme A oxidase; Region: PLN02636
1118963006977	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1118963006978	active site
1118963006979	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963006980	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963006981	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
1118963006982	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1118963006983	dimer interface [polypeptide binding]; other site
1118963006984	active site
1118963006985	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
1118963006986	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963006987	NAD(P) binding site [chemical binding]; other site
1118963006988	active site
1118963006989	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1118963006990	active site 2 [active]
1118963006991	active site 1 [active]
1118963006992	hypothetical protein; Provisional; Region: PRK07906
1118963006993	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
1118963006994	putative metal binding site [ion binding]; other site
1118963006995	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1118963006996	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932
1118963006997	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1118963006998	active site
1118963006999	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1118963007000	CoA binding domain; Region: CoA_binding; cl17356
1118963007001	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1118963007002	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963007003	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963007004	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963007005	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963007006	NAD(P) binding site [chemical binding]; other site
1118963007007	active site
1118963007008	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1118963007009	inhibitor-cofactor binding pocket; inhibition site
1118963007010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963007011	catalytic residue [active]
1118963007012	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1118963007013	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1118963007014	putative trimer interface [polypeptide binding]; other site
1118963007015	putative CoA binding site [chemical binding]; other site
1118963007016	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1118963007017	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1118963007018	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1118963007019	colanic acid exporter; Provisional; Region: PRK10459
1118963007020	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1118963007021	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1118963007022	active site
1118963007023	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1118963007024	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1118963007025	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1118963007026	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1118963007027	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
1118963007028	putative ADP-binding pocket [chemical binding]; other site
1118963007029	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1118963007030	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1118963007031	active site
1118963007032	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1118963007033	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1118963007034	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1118963007035	Probable Catalytic site; other site
1118963007036	metal-binding site
1118963007037	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1118963007038	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
1118963007039	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1118963007040	NADP binding site [chemical binding]; other site
1118963007041	active site
1118963007042	putative substrate binding site [chemical binding]; other site
1118963007043	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1118963007044	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1118963007045	NAD binding site [chemical binding]; other site
1118963007046	substrate binding site [chemical binding]; other site
1118963007047	homodimer interface [polypeptide binding]; other site
1118963007048	active site
1118963007049	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1118963007050	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1118963007051	substrate binding site; other site
1118963007052	tetramer interface; other site
1118963007053	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963007054	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963007055	active site
1118963007056	catalytic tetrad [active]
1118963007057	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
1118963007058	cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447
1118963007059	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1118963007060	active site
1118963007061	nucleotide binding site [chemical binding]; other site
1118963007062	HIGH motif; other site
1118963007063	KMSKS motif; other site
1118963007064	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1118963007065	tRNA binding surface [nucleotide binding]; other site
1118963007066	anticodon binding site; other site
1118963007067	PAC2 family; Region: PAC2; pfam09754
1118963007068	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1118963007069	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1118963007070	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963007071	active site
1118963007072	motif I; other site
1118963007073	motif II; other site
1118963007074	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
1118963007075	Peptidase family M50; Region: Peptidase_M50; pfam02163
1118963007076	active site
1118963007077	putative substrate binding region [chemical binding]; other site
1118963007078	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1118963007079	tRNA methyltransferase complex GCD14 subunit N-term; Region: GCD14_N; pfam14801
1118963007080	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1118963007081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963007082	S-adenosylmethionine binding site [chemical binding]; other site
1118963007083	proteasome ATPase; Region: pup_AAA; TIGR03689
1118963007084	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963007085	Walker A motif; other site
1118963007086	ATP binding site [chemical binding]; other site
1118963007087	Walker B motif; other site
1118963007088	arginine finger; other site
1118963007089	Pup-ligase protein; Region: Pup_ligase; pfam03136
1118963007090	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
1118963007091	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1118963007092	active site
1118963007093	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
1118963007094	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1118963007095	active site
1118963007096	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
1118963007097	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1118963007098	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1118963007099	WYL domain; Region: WYL; pfam13280
1118963007100	Predicted transcriptional regulator [Transcription]; Region: COG2378
1118963007101	WYL domain; Region: WYL; pfam13280
1118963007102	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
1118963007103	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
1118963007104	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
1118963007105	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963007106	ATP binding site [chemical binding]; other site
1118963007107	putative Mg++ binding site [ion binding]; other site
1118963007108	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963007109	nucleotide binding region [chemical binding]; other site
1118963007110	ATP-binding site [chemical binding]; other site
1118963007111	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
1118963007112	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1118963007113	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1118963007114	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963007115	active site
1118963007116	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1118963007117	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1118963007118	Ligand binding site; other site
1118963007119	Putative Catalytic site; other site
1118963007120	DXD motif; other site
1118963007121	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
1118963007122	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1118963007123	Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829
1118963007124	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
1118963007125	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1118963007126	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963007127	S-adenosylmethionine binding site [chemical binding]; other site
1118963007128	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1118963007129	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1118963007130	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1118963007131	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1118963007132	active site
1118963007133	catalytic residues [active]
1118963007134	metal binding site [ion binding]; metal-binding site
1118963007135	SnoaL-like domain; Region: SnoaL_2; pfam12680
1118963007136	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1118963007137	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963007138	Squalene epoxidase; Region: SE; cl17314
1118963007139	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963007140	S-adenosylmethionine binding site [chemical binding]; other site
1118963007141	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1118963007142	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1118963007143	malonyl-CoA binding site [chemical binding]; other site
1118963007144	dimer interface [polypeptide binding]; other site
1118963007145	active site
1118963007146	product binding site; other site
1118963007147	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1118963007148	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963007149	Walker A/P-loop; other site
1118963007150	ATP binding site [chemical binding]; other site
1118963007151	Q-loop/lid; other site
1118963007152	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963007153	Q-loop/lid; other site
1118963007154	ABC transporter signature motif; other site
1118963007155	Walker B; other site
1118963007156	D-loop; other site
1118963007157	H-loop/switch region; other site
1118963007158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963007159	Walker A/P-loop; other site
1118963007160	ATP binding site [chemical binding]; other site
1118963007161	Q-loop/lid; other site
1118963007162	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048
1118963007163	ABC transporter signature motif; other site
1118963007164	Walker B; other site
1118963007165	D-loop; other site
1118963007166	H-loop/switch region; other site
1118963007167	Immunoglobulin domain; Region: Ig; cl11960
1118963007168	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1118963007169	dimer interface [polypeptide binding]; other site
1118963007170	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1118963007171	dimer interface [polypeptide binding]; other site
1118963007172	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1118963007173	active site
1118963007174	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
1118963007175	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963007176	AsnC family; Region: AsnC_trans_reg; pfam01037
1118963007177	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1118963007178	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1118963007179	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1118963007180	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1118963007181	Subunit I/III interface [polypeptide binding]; other site
1118963007182	Cytochrome c; Region: Cytochrom_C; pfam00034
1118963007183	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1118963007184	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1118963007185	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1118963007186	iron-sulfur cluster [ion binding]; other site
1118963007187	[2Fe-2S] cluster binding site [ion binding]; other site
1118963007188	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1118963007189	heme bH binding site [chemical binding]; other site
1118963007190	Qi binding site; other site
1118963007191	intrachain domain interface; other site
1118963007192	heme bL binding site [chemical binding]; other site
1118963007193	interchain domain interface [polypeptide binding]; other site
1118963007194	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
1118963007195	Qo binding site; other site
1118963007196	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1118963007197	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963007198	DNA-binding site [nucleotide binding]; DNA binding site
1118963007199	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1118963007200	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
1118963007201	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
1118963007202	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1118963007203	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1118963007204	D-pathway; other site
1118963007205	Putative ubiquinol binding site [chemical binding]; other site
1118963007206	Low-spin heme (heme b) binding site [chemical binding]; other site
1118963007207	Putative water exit pathway; other site
1118963007208	Binuclear center (heme o3/CuB) [ion binding]; other site
1118963007209	K-pathway; other site
1118963007210	Putative proton exit pathway; other site
1118963007211	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
1118963007212	Uncharacterized subfamily with similarity to Heme-copper oxidase subunit II cupredoxin domain; Region: CuRO_HCO_II_like_5; cd13919
1118963007213	CuA binuclear center [ion binding]; other site
1118963007214	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1118963007215	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
1118963007216	hypothetical protein; Provisional; Region: PRK08201
1118963007217	active site
1118963007218	metal binding site [ion binding]; metal-binding site
1118963007219	dimer interface [polypeptide binding]; other site
1118963007220	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
1118963007221	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1118963007222	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1118963007223	quinone interaction residues [chemical binding]; other site
1118963007224	active site
1118963007225	catalytic residues [active]
1118963007226	FMN binding site [chemical binding]; other site
1118963007227	substrate binding site [chemical binding]; other site
1118963007228	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1118963007229	Predicted oxidoreductase [General function prediction only]; Region: COG3573
1118963007230	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963007231	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963007232	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963007233	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963007234	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
1118963007235	active site
1118963007236	dimer interface [polypeptide binding]; other site
1118963007237	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1118963007238	Recombination protein O N terminal; Region: RecO_N; pfam11967
1118963007239	Recombination protein O C terminal; Region: RecO_C; pfam02565
1118963007240	2-isopropylmalate synthase; Validated; Region: PRK03739
1118963007241	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1118963007242	active site
1118963007243	catalytic residues [active]
1118963007244	metal binding site [ion binding]; metal-binding site
1118963007245	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1118963007246	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1118963007247	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1118963007248	active site
1118963007249	Zn binding site [ion binding]; other site
1118963007250	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
1118963007251	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1118963007252	GTPase Era; Reviewed; Region: era; PRK00089
1118963007253	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1118963007254	G1 box; other site
1118963007255	GTP/Mg2+ binding site [chemical binding]; other site
1118963007256	Switch I region; other site
1118963007257	G2 box; other site
1118963007258	Switch II region; other site
1118963007259	G3 box; other site
1118963007260	G4 box; other site
1118963007261	G5 box; other site
1118963007262	KH domain; Region: KH_2; pfam07650
1118963007263	Domain of unknown function DUF21; Region: DUF21; pfam01595
1118963007264	FOG: CBS domain [General function prediction only]; Region: COG0517
1118963007265	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1118963007266	Transporter associated domain; Region: CorC_HlyC; smart01091
1118963007267	metal-binding heat shock protein; Provisional; Region: PRK00016
1118963007268	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1118963007269	PhoH-like protein; Region: PhoH; pfam02562
1118963007270	Sporulation and spore germination; Region: Germane; pfam10646
1118963007271	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1118963007272	chaperone protein DnaJ; Provisional; Region: PRK14278
1118963007273	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1118963007274	HSP70 interaction site [polypeptide binding]; other site
1118963007275	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1118963007276	substrate binding site [polypeptide binding]; other site
1118963007277	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1118963007278	Zn binding sites [ion binding]; other site
1118963007279	dimer interface [polypeptide binding]; other site
1118963007280	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1118963007281	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1118963007282	HrcA protein C terminal domain; Region: HrcA; pfam01628
1118963007283	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
1118963007284	Tic20-like protein; Region: Tic20; pfam09685
1118963007285	coproporphyrinogen III oxidase; Validated; Region: PRK05628
1118963007286	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1118963007287	FeS/SAM binding site; other site
1118963007288	GTP-binding protein LepA; Provisional; Region: PRK05433
1118963007289	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1118963007290	G1 box; other site
1118963007291	putative GEF interaction site [polypeptide binding]; other site
1118963007292	GTP/Mg2+ binding site [chemical binding]; other site
1118963007293	Switch I region; other site
1118963007294	G2 box; other site
1118963007295	G3 box; other site
1118963007296	Switch II region; other site
1118963007297	G4 box; other site
1118963007298	G5 box; other site
1118963007299	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1118963007300	Elongation Factor G, domain II; Region: EFG_II; pfam14492
1118963007301	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1118963007302	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1118963007303	PemK-like protein; Region: PemK; pfam02452
1118963007304	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1118963007305	hypothetical protein; Reviewed; Region: PRK07914
1118963007306	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912
1118963007307	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1118963007308	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1118963007309	Competence protein; Region: Competence; pfam03772
1118963007310	SLBB domain; Region: SLBB; pfam10531
1118963007311	comEA protein; Region: comE; TIGR01259
1118963007312	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1118963007313	EDD domain protein, DegV family; Region: DegV; TIGR00762
1118963007314	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1118963007315	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1118963007316	active site
1118963007317	HIGH motif; other site
1118963007318	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1118963007319	KMSKS motif; other site
1118963007320	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1118963007321	tRNA binding surface [nucleotide binding]; other site
1118963007322	glycerol kinase; Region: glycerol_kin; TIGR01311
1118963007323	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963007324	nucleotide binding site [chemical binding]; other site
1118963007325	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1118963007326	amphipathic channel; other site
1118963007327	Asn-Pro-Ala signature motifs; other site
1118963007328	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1118963007329	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963007330	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1118963007331	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1118963007332	DNA binding residues [nucleotide binding]
1118963007333	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1118963007334	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963007335	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963007336	active site
1118963007337	catalytic tetrad [active]
1118963007338	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
1118963007339	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963007340	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963007341	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1118963007342	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1118963007343	benzoate transport; Region: 2A0115; TIGR00895
1118963007344	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963007345	putative substrate translocation pore; other site
1118963007346	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1118963007347	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1118963007348	FMN-binding pocket [chemical binding]; other site
1118963007349	flavin binding motif; other site
1118963007350	phosphate binding motif [ion binding]; other site
1118963007351	beta-alpha-beta structure motif; other site
1118963007352	NAD binding pocket [chemical binding]; other site
1118963007353	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1118963007354	catalytic loop [active]
1118963007355	iron binding site [ion binding]; other site
1118963007356	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1118963007357	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1118963007358	iron-sulfur cluster [ion binding]; other site
1118963007359	[2Fe-2S] cluster binding site [ion binding]; other site
1118963007360	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1118963007361	alpha subunit interface [polypeptide binding]; other site
1118963007362	active site
1118963007363	substrate binding site [chemical binding]; other site
1118963007364	Fe binding site [ion binding]; other site
1118963007365	Predicted transcriptional regulators [Transcription]; Region: COG1695
1118963007366	primosome assembly protein PriA; Provisional; Region: PRK14873
1118963007367	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1118963007368	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1118963007369	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1118963007370	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1118963007371	Flavoprotein; Region: Flavoprotein; cl19190
1118963007372	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1118963007373	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
1118963007374	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1118963007375	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1118963007376	Guanylate kinase; Region: Guanylate_kin; pfam00625
1118963007377	catalytic site [active]
1118963007378	G-X2-G-X-G-K; other site
1118963007379	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1118963007380	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1118963007381	active site
1118963007382	dimer interface [polypeptide binding]; other site
1118963007383	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1118963007384	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1118963007385	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1118963007386	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
1118963007387	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1118963007388	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1118963007389	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1118963007390	IMP binding site; other site
1118963007391	dimer interface [polypeptide binding]; other site
1118963007392	interdomain contacts; other site
1118963007393	partial ornithine binding site; other site
1118963007394	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1118963007395	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1118963007396	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1118963007397	catalytic site [active]
1118963007398	subunit interface [polypeptide binding]; other site
1118963007399	dihydroorotase; Validated; Region: pyrC; PRK09357
1118963007400	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963007401	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1118963007402	active site
1118963007403	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1118963007404	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1118963007405	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1118963007406	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1118963007407	active site
1118963007408	Protease prsW family; Region: PrsW-protease; pfam13367
1118963007409	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1118963007410	putative RNA binding site [nucleotide binding]; other site
1118963007411	elongation factor P; Validated; Region: PRK00529
1118963007412	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1118963007413	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1118963007414	RNA binding site [nucleotide binding]; other site
1118963007415	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1118963007416	RNA binding site [nucleotide binding]; other site
1118963007417	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1118963007418	TPR motif; other site
1118963007419	binding surface
1118963007420	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1118963007421	active site
1118963007422	dimer interface [polypeptide binding]; other site
1118963007423	metal binding site [ion binding]; metal-binding site
1118963007424	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1118963007425	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1118963007426	ADP binding site [chemical binding]; other site
1118963007427	magnesium binding site [ion binding]; other site
1118963007428	putative shikimate binding site; other site
1118963007429	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1118963007430	Tetramer interface [polypeptide binding]; other site
1118963007431	active site
1118963007432	FMN-binding site [chemical binding]; other site
1118963007433	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1118963007434	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1118963007435	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1118963007436	shikimate binding site; other site
1118963007437	NAD(P) binding site [chemical binding]; other site
1118963007438	YceG-like family; Region: YceG; pfam02618
1118963007439	dimerization interface [polypeptide binding]; other site
1118963007440	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
1118963007441	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1118963007442	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1118963007443	motif 1; other site
1118963007444	active site
1118963007445	motif 2; other site
1118963007446	motif 3; other site
1118963007447	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
1118963007448	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
1118963007449	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1118963007450	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1118963007451	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1118963007452	RNA binding surface [nucleotide binding]; other site
1118963007453	recombination factor protein RarA; Reviewed; Region: PRK13342
1118963007454	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963007455	Walker A motif; other site
1118963007456	ATP binding site [chemical binding]; other site
1118963007457	Walker B motif; other site
1118963007458	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1118963007459	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963007460	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1118963007461	Coenzyme A binding pocket [chemical binding]; other site
1118963007462	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1118963007463	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1118963007464	dimer interface [polypeptide binding]; other site
1118963007465	anticodon binding site; other site
1118963007466	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1118963007467	homodimer interface [polypeptide binding]; other site
1118963007468	motif 1; other site
1118963007469	active site
1118963007470	motif 2; other site
1118963007471	GAD domain; Region: GAD; pfam02938
1118963007472	motif 3; other site
1118963007473	histidyl-tRNA synthetase; Region: hisS; TIGR00442
1118963007474	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1118963007475	dimer interface [polypeptide binding]; other site
1118963007476	motif 1; other site
1118963007477	active site
1118963007478	motif 2; other site
1118963007479	motif 3; other site
1118963007480	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
1118963007481	anticodon binding site; other site
1118963007482	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1118963007483	active site
1118963007484	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1118963007485	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1118963007486	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1118963007487	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1118963007488	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1118963007489	Zn2+ binding site [ion binding]; other site
1118963007490	Mg2+ binding site [ion binding]; other site
1118963007491	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1118963007492	synthetase active site [active]
1118963007493	NTP binding site [chemical binding]; other site
1118963007494	metal binding site [ion binding]; metal-binding site
1118963007495	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1118963007496	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1118963007497	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1118963007498	Protein export membrane protein; Region: SecD_SecF; pfam02355
1118963007499	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1118963007500	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1118963007501	Preprotein translocase subunit; Region: YajC; pfam02699
1118963007502	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1118963007503	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963007504	Walker A motif; other site
1118963007505	ATP binding site [chemical binding]; other site
1118963007506	Walker B motif; other site
1118963007507	arginine finger; other site
1118963007508	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1118963007509	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1118963007510	RuvA N terminal domain; Region: RuvA_N; pfam01330
1118963007511	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
1118963007512	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1118963007513	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
1118963007514	putative DNA-binding cleft [nucleotide binding]; other site
1118963007515	dimer interface [polypeptide binding]; other site
1118963007516	active site
1118963007517	hypothetical protein; Validated; Region: PRK00110
1118963007518	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1118963007519	predicted active site [active]
1118963007520	catalytic triad [active]
1118963007521	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1118963007522	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1118963007523	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1118963007524	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1118963007525	catalytic triad [active]
1118963007526	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1118963007527	putative active site [active]
1118963007528	putative metal binding site [ion binding]; other site
1118963007529	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1118963007530	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1118963007531	active site
1118963007532	Zn binding site [ion binding]; other site
1118963007533	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1118963007534	active site
1118963007535	multimer interface [polypeptide binding]; other site
1118963007536	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1118963007537	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1118963007538	nucleotide binding site/active site [active]
1118963007539	HIT family signature motif; other site
1118963007540	catalytic residue [active]
1118963007541	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1118963007542	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1118963007543	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1118963007544	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1118963007545	active site
1118963007546	dimer interface [polypeptide binding]; other site
1118963007547	motif 1; other site
1118963007548	motif 2; other site
1118963007549	motif 3; other site
1118963007550	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1118963007551	anticodon binding site; other site
1118963007552	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1118963007553	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1118963007554	active site
1118963007555	PHP Thumb interface [polypeptide binding]; other site
1118963007556	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1118963007557	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
1118963007558	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1118963007559	generic binding surface II; other site
1118963007560	generic binding surface I; other site
1118963007561	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963007562	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1118963007563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1118963007564	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1118963007565	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1118963007566	catalytic residues [active]
1118963007567	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
1118963007568	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1118963007569	NAD(P) binding site [chemical binding]; other site
1118963007570	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1118963007571	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1118963007572	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1118963007573	putative molybdopterin cofactor binding site [chemical binding]; other site
1118963007574	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1118963007575	putative molybdopterin cofactor binding site; other site
1118963007576	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1118963007577	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1118963007578	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1118963007579	MAEBL; Provisional; Region: PTZ00121
1118963007580	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963007581	FAD dependent oxidoreductase; Region: DAO; pfam01266
1118963007582	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963007583	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1118963007584	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1118963007585	iron-sulfur cluster [ion binding]; other site
1118963007586	[2Fe-2S] cluster binding site [ion binding]; other site
1118963007587	A new structural DNA glycosylase; Region: AlkD_like; cl11434
1118963007588	Protein of unknown function (DUF1016); Region: DUF1016; cl19557
1118963007589	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1118963007590	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1118963007591	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963007592	Walker A/P-loop; other site
1118963007593	ATP binding site [chemical binding]; other site
1118963007594	Q-loop/lid; other site
1118963007595	ABC transporter signature motif; other site
1118963007596	Walker B; other site
1118963007597	D-loop; other site
1118963007598	H-loop/switch region; other site
1118963007599	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1118963007600	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1118963007601	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963007602	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1118963007603	NAD(P) binding site [chemical binding]; other site
1118963007604	active site
1118963007605	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1118963007606	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1118963007607	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1118963007608	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1118963007609	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1118963007610	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1118963007611	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1118963007612	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1118963007613	dimer interface [polypeptide binding]; other site
1118963007614	active site
1118963007615	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1118963007616	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1118963007617	active site
1118963007618	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1118963007619	dimer interface [polypeptide binding]; other site
1118963007620	putative radical transfer pathway; other site
1118963007621	diiron center [ion binding]; other site
1118963007622	tyrosyl radical; other site
1118963007623	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1118963007624	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1118963007625	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1118963007626	active site
1118963007627	dimer interface [polypeptide binding]; other site
1118963007628	catalytic residues [active]
1118963007629	effector binding site; other site
1118963007630	R2 peptide binding site; other site
1118963007631	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1118963007632	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1118963007633	catalytic residues [active]
1118963007634	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963007635	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963007636	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963007637	dimerization interface [polypeptide binding]; other site
1118963007638	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
1118963007639	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1118963007640	metal ion-dependent adhesion site (MIDAS); other site
1118963007641	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1118963007642	metal ion-dependent adhesion site (MIDAS); other site
1118963007643	Protein of unknown function DUF58; Region: DUF58; pfam01882
1118963007644	MoxR-like ATPases [General function prediction only]; Region: COG0714
1118963007645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963007646	Walker A motif; other site
1118963007647	ATP binding site [chemical binding]; other site
1118963007648	Walker B motif; other site
1118963007649	arginine finger; other site
1118963007650	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963007651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963007652	dimer interface [polypeptide binding]; other site
1118963007653	conserved gate region; other site
1118963007654	putative PBP binding loops; other site
1118963007655	ABC-ATPase subunit interface; other site
1118963007656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963007657	dimer interface [polypeptide binding]; other site
1118963007658	conserved gate region; other site
1118963007659	putative PBP binding loops; other site
1118963007660	ABC-ATPase subunit interface; other site
1118963007661	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963007662	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963007663	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963007664	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963007665	putative DNA binding site [nucleotide binding]; other site
1118963007666	putative Zn2+ binding site [ion binding]; other site
1118963007667	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963007668	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963007669	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1118963007670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963007671	S-adenosylmethionine binding site [chemical binding]; other site
1118963007672	Cupin domain; Region: Cupin_2; cl17218
1118963007673	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963007674	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963007675	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1118963007676	DNA topoisomerase 2; Provisional; Region: PLN03237
1118963007677	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1118963007678	active site
1118963007679	(T/H)XGH motif; other site
1118963007680	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1118963007681	putative catalytic cysteine [active]
1118963007682	gamma-glutamyl kinase; Provisional; Region: PRK05429
1118963007683	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1118963007684	nucleotide binding site [chemical binding]; other site
1118963007685	homotetrameric interface [polypeptide binding]; other site
1118963007686	putative phosphate binding site [ion binding]; other site
1118963007687	putative allosteric binding site; other site
1118963007688	PUA domain; Region: PUA; pfam01472
1118963007689	GTPase CgtA; Reviewed; Region: obgE; PRK12296
1118963007690	GTP1/OBG; Region: GTP1_OBG; pfam01018
1118963007691	Obg GTPase; Region: Obg; cd01898
1118963007692	G1 box; other site
1118963007693	GTP/Mg2+ binding site [chemical binding]; other site
1118963007694	Switch I region; other site
1118963007695	G2 box; other site
1118963007696	G3 box; other site
1118963007697	Switch II region; other site
1118963007698	G4 box; other site
1118963007699	G5 box; other site
1118963007700	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1118963007701	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1118963007702	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1118963007703	multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713
1118963007704	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1118963007705	dimer interface [polypeptide binding]; other site
1118963007706	substrate binding site [chemical binding]; other site
1118963007707	ATP binding site [chemical binding]; other site
1118963007708	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1118963007709	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1118963007710	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1118963007711	homodimer interface [polypeptide binding]; other site
1118963007712	oligonucleotide binding site [chemical binding]; other site
1118963007713	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
1118963007714	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
1118963007715	putative active site [active]
1118963007716	redox center [active]
1118963007717	Nucleoside diphosphate kinase; Region: NDK; pfam00334
1118963007718	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1118963007719	active site
1118963007720	multimer interface [polypeptide binding]; other site
1118963007721	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
1118963007722	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1118963007723	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1118963007724	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1118963007725	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1118963007726	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1118963007727	active site
1118963007728	HIGH motif; other site
1118963007729	nucleotide binding site [chemical binding]; other site
1118963007730	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1118963007731	active site
1118963007732	KMSKS motif; other site
1118963007733	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1118963007734	tRNA binding surface [nucleotide binding]; other site
1118963007735	anticodon binding site; other site
1118963007736	Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372
1118963007737	putative catalytic site [active]
1118963007738	putative metal binding site [ion binding]; other site
1118963007739	putative phosphate binding site [ion binding]; other site
1118963007740	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1118963007741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963007742	NAD(P) binding site [chemical binding]; other site
1118963007743	active site
1118963007744	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
1118963007745	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1118963007746	active site
1118963007747	nucleotide binding site [chemical binding]; other site
1118963007748	HIGH motif; other site
1118963007749	KMSKS motif; other site
1118963007750	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1118963007751	tRNA binding surface [nucleotide binding]; other site
1118963007752	anticodon binding site; other site
1118963007753	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1118963007754	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
1118963007755	putative DNA binding site [nucleotide binding]; other site
1118963007756	catalytic residue [active]
1118963007757	putative H2TH interface [polypeptide binding]; other site
1118963007758	putative catalytic residues [active]
1118963007759	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1118963007760	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1118963007761	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1118963007762	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1118963007763	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1118963007764	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1118963007765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963007766	Walker A motif; other site
1118963007767	ATP binding site [chemical binding]; other site
1118963007768	Walker B motif; other site
1118963007769	arginine finger; other site
1118963007770	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1118963007771	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1118963007772	oligomer interface [polypeptide binding]; other site
1118963007773	active site residues [active]
1118963007774	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1118963007775	oligomer interface [polypeptide binding]; other site
1118963007776	active site residues [active]
1118963007777	trigger factor; Provisional; Region: tig; PRK01490
1118963007778	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
1118963007779	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1118963007780	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1118963007781	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1118963007782	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
1118963007783	putative DNA binding site [nucleotide binding]; other site
1118963007784	catalytic residue [active]
1118963007785	putative H2TH interface [polypeptide binding]; other site
1118963007786	putative catalytic residues [active]
1118963007787	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1118963007788	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1118963007789	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
1118963007790	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
1118963007791	Zn binding site [ion binding]; other site
1118963007792	ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838
1118963007793	OsmC-like protein; Region: OsmC; cl00767
1118963007794	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963007795	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1118963007796	NAD(P) binding site [chemical binding]; other site
1118963007797	active site
1118963007798	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1118963007799	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1118963007800	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1118963007801	apolar tunnel; other site
1118963007802	heme binding site [chemical binding]; other site
1118963007803	dimerization interface [polypeptide binding]; other site
1118963007804	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1118963007805	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1118963007806	active site
1118963007807	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1118963007808	catalytic triad [active]
1118963007809	dimer interface [polypeptide binding]; other site
1118963007810	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1118963007811	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963007812	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963007813	Walker A/P-loop; other site
1118963007814	ATP binding site [chemical binding]; other site
1118963007815	Q-loop/lid; other site
1118963007816	ABC transporter signature motif; other site
1118963007817	Walker B; other site
1118963007818	D-loop; other site
1118963007819	ABC transporter; Region: ABC_tran_2; pfam12848
1118963007820	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963007821	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
1118963007822	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1118963007823	putative hydrophobic ligand binding site [chemical binding]; other site
1118963007824	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1118963007825	dimer interface [polypeptide binding]; other site
1118963007826	ssDNA binding site [nucleotide binding]; other site
1118963007827	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1118963007828	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1118963007829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963007830	Coenzyme A binding pocket [chemical binding]; other site
1118963007831	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1118963007832	active site
1118963007833	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
1118963007834	active site
1118963007835	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1118963007836	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1118963007837	putative active site [active]
1118963007838	putative substrate binding site [chemical binding]; other site
1118963007839	dimer interface [polypeptide binding]; other site
1118963007840	catalytic site [active]
1118963007841	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1118963007842	active site
1118963007843	catalytic residues [active]
1118963007844	metal binding site [ion binding]; metal-binding site
1118963007845	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1118963007846	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
1118963007847	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1118963007848	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1118963007849	hypothetical protein; Validated; Region: PRK02101
1118963007850	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1118963007851	Putative zinc ribbon domain; Region: DUF164; pfam02591
1118963007852	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1118963007853	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1118963007854	cysteine synthase; Region: PLN02565
1118963007855	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1118963007856	dimer interface [polypeptide binding]; other site
1118963007857	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963007858	catalytic residue [active]
1118963007859	serine O-acetyltransferase; Region: cysE; TIGR01172
1118963007860	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1118963007861	trimer interface [polypeptide binding]; other site
1118963007862	active site
1118963007863	substrate binding site [chemical binding]; other site
1118963007864	CoA binding site [chemical binding]; other site
1118963007865	short chain dehydrogenase; Validated; Region: PRK06182
1118963007866	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1118963007867	NADP binding site [chemical binding]; other site
1118963007868	active site
1118963007869	steroid binding site; other site
1118963007870	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1118963007871	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1118963007872	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1118963007873	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1118963007874	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963007875	DNA-binding site [nucleotide binding]; DNA binding site
1118963007876	FCD domain; Region: FCD; pfam07729
1118963007877	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
1118963007878	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
1118963007879	putative NAD(P) binding site [chemical binding]; other site
1118963007880	catalytic Zn binding site [ion binding]; other site
1118963007881	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
1118963007882	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1118963007883	NADP binding site [chemical binding]; other site
1118963007884	homodimer interface [polypeptide binding]; other site
1118963007885	active site
1118963007886	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1118963007887	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1118963007888	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
1118963007889	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
1118963007890	NAD binding site [chemical binding]; other site
1118963007891	ligand binding site [chemical binding]; other site
1118963007892	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1118963007893	catalytic site [active]
1118963007894	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1118963007895	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963007896	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963007897	putative substrate translocation pore; other site
1118963007898	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963007899	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963007900	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963007901	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1118963007902	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1118963007903	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
1118963007904	dimer interface [polypeptide binding]; other site
1118963007905	catalytic triad [active]
1118963007906	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
1118963007907	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1118963007908	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1118963007909	dimer interface [polypeptide binding]; other site
1118963007910	TPP-binding site [chemical binding]; other site
1118963007911	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1118963007912	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1118963007913	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1118963007914	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1118963007915	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1118963007916	dimer interface [polypeptide binding]; other site
1118963007917	active site
1118963007918	CoA binding pocket [chemical binding]; other site
1118963007919	acyl carrier protein; Provisional; Region: acpP; PRK00982
1118963007920	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1118963007921	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1118963007922	dimer interface [polypeptide binding]; other site
1118963007923	active site
1118963007924	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
1118963007925	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1118963007926	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1118963007927	active site
1118963007928	DNA binding site [nucleotide binding]
1118963007929	Int/Topo IB signature motif; other site
1118963007930	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1118963007931	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1118963007932	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1118963007933	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1118963007934	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963007935	Walker A motif; other site
1118963007936	ATP binding site [chemical binding]; other site
1118963007937	Walker B motif; other site
1118963007938	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1118963007939	hypothetical protein; Reviewed; Region: PRK12497
1118963007940	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
1118963007941	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1118963007942	RNA/DNA hybrid binding site [nucleotide binding]; other site
1118963007943	active site
1118963007944	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1118963007945	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1118963007946	Catalytic site [active]
1118963007947	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
1118963007948	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1118963007949	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1118963007950	Catalytic site [active]
1118963007951	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1118963007952	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1118963007953	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1118963007954	RimM N-terminal domain; Region: RimM; pfam01782
1118963007955	hypothetical protein; Provisional; Region: PRK02821
1118963007956	G-X-X-G motif; other site
1118963007957	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
1118963007958	ribosomal protein S16; Region: S16; TIGR00002
1118963007959	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1118963007960	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1118963007961	putative metal binding site [ion binding]; other site
1118963007962	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1118963007963	active site
1118963007964	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963007965	Amidohydrolase; Region: Amidohydro_4; pfam13147
1118963007966	active site
1118963007967	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1118963007968	ThiC-associated domain; Region: ThiC-associated; pfam13667
1118963007969	ThiC family; Region: ThiC; pfam01964
1118963007970	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963007971	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1118963007972	catalytic site [active]
1118963007973	signal recognition particle protein; Provisional; Region: PRK10867
1118963007974	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1118963007975	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1118963007976	P loop; other site
1118963007977	GTP binding site [chemical binding]; other site
1118963007978	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1118963007979	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
1118963007980	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1118963007981	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1118963007982	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1118963007983	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1118963007984	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1118963007985	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963007986	putative substrate translocation pore; other site
1118963007987	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1118963007988	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1118963007989	SRP54-type protein, GTPase domain; Region: SRP54; pfam00448
1118963007990	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1118963007991	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1118963007992	Walker A/P-loop; other site
1118963007993	ATP binding site [chemical binding]; other site
1118963007994	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1118963007995	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1118963007996	ABC transporter signature motif; other site
1118963007997	Walker B; other site
1118963007998	D-loop; other site
1118963007999	H-loop/switch region; other site
1118963008000	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1118963008001	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
1118963008002	Bacterial Ig-like domain; Region: Big_5; pfam13205
1118963008003	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
1118963008004	Bacterial Ig-like domain; Region: Big_5; pfam13205
1118963008005	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
1118963008006	Bacterial Ig-like domain; Region: Big_5; pfam13205
1118963008007	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
1118963008008	translocation protein TolB; Provisional; Region: tolB; PRK03629
1118963008009	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963008010	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963008011	putative substrate translocation pore; other site
1118963008012	Merozoite surface antigen 2c; Region: MSA-2c; pfam12238
1118963008013	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1118963008014	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1118963008015	DNA binding site [nucleotide binding]
1118963008016	catalytic residue [active]
1118963008017	H2TH interface [polypeptide binding]; other site
1118963008018	putative catalytic residues [active]
1118963008019	turnover-facilitating residue; other site
1118963008020	intercalation triad [nucleotide binding]; other site
1118963008021	8OG recognition residue [nucleotide binding]; other site
1118963008022	putative reading head residues; other site
1118963008023	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1118963008024	ribonuclease III; Reviewed; Region: rnc; PRK00102
1118963008025	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1118963008026	dimerization interface [polypeptide binding]; other site
1118963008027	active site
1118963008028	metal binding site [ion binding]; metal-binding site
1118963008029	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1118963008030	dsRNA binding site [nucleotide binding]; other site
1118963008031	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1118963008032	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
1118963008033	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1118963008034	active site
1118963008035	(T/H)XGH motif; other site
1118963008036	aminotransferase; Validated; Region: PRK07777
1118963008037	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963008038	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963008039	homodimer interface [polypeptide binding]; other site
1118963008040	catalytic residue [active]
1118963008041	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1118963008042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963008043	S-adenosylmethionine binding site [chemical binding]; other site
1118963008044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963008045	S-adenosylmethionine binding site [chemical binding]; other site
1118963008046	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1118963008047	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1118963008048	generic binding surface II; other site
1118963008049	ssDNA binding site; other site
1118963008050	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963008051	ATP binding site [chemical binding]; other site
1118963008052	putative Mg++ binding site [ion binding]; other site
1118963008053	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963008054	nucleotide binding region [chemical binding]; other site
1118963008055	ATP-binding site [chemical binding]; other site
1118963008056	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
1118963008057	DAK2 domain; Region: Dak2; pfam02734
1118963008058	Uncharacterized protein, DegV family COG1307; Region: DegV; cl19360
1118963008059	thiamine monophosphate kinase; Provisional; Region: PRK05731
1118963008060	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1118963008061	ATP binding site [chemical binding]; other site
1118963008062	dimerization interface [polypeptide binding]; other site
1118963008063	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1118963008064	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1118963008065	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1118963008066	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1118963008067	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1118963008068	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1118963008069	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1118963008070	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1118963008071	putative acyl-acceptor binding pocket; other site
1118963008072	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
1118963008073	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1118963008074	hinge; other site
1118963008075	active site
1118963008076	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1118963008077	substrate binding site [chemical binding]; other site
1118963008078	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1118963008079	substrate binding site [chemical binding]; other site
1118963008080	ligand binding site [chemical binding]; other site
1118963008081	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963008082	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963008083	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963008084	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
1118963008085	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1118963008086	G1 box; other site
1118963008087	GTP/Mg2+ binding site [chemical binding]; other site
1118963008088	G2 box; other site
1118963008089	Switch I region; other site
1118963008090	G3 box; other site
1118963008091	Switch II region; other site
1118963008092	G4 box; other site
1118963008093	G5 box; other site
1118963008094	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1118963008095	G1 box; other site
1118963008096	GTP/Mg2+ binding site [chemical binding]; other site
1118963008097	G2 box; other site
1118963008098	Switch I region; other site
1118963008099	G3 box; other site
1118963008100	Switch II region; other site
1118963008101	G5 box; other site
1118963008102	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1118963008103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963008104	motif II; other site
1118963008105	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1118963008106	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1118963008107	active site
1118963008108	HIGH motif; other site
1118963008109	KMSKS motif; other site
1118963008110	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1118963008111	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1118963008112	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1118963008113	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1118963008114	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1118963008115	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1118963008116	homodimer interface [polypeptide binding]; other site
1118963008117	substrate-cofactor binding pocket; other site
1118963008118	catalytic residue [active]
1118963008119	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
1118963008120	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1118963008121	Histidine kinase; Region: HisKA_3; pfam07730
1118963008122	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1118963008123	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963008124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963008125	active site
1118963008126	phosphorylation site [posttranslational modification]
1118963008127	intermolecular recognition site; other site
1118963008128	dimerization interface [polypeptide binding]; other site
1118963008129	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963008130	DNA binding residues [nucleotide binding]
1118963008131	dimerization interface [polypeptide binding]; other site
1118963008132	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1118963008133	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1118963008134	Walker A/P-loop; other site
1118963008135	ATP binding site [chemical binding]; other site
1118963008136	Q-loop/lid; other site
1118963008137	ABC transporter signature motif; other site
1118963008138	Walker B; other site
1118963008139	D-loop; other site
1118963008140	H-loop/switch region; other site
1118963008141	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1118963008142	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1118963008143	FtsX-like permease family; Region: FtsX; pfam02687
1118963008144	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1118963008145	FtsX-like permease family; Region: FtsX; pfam02687
1118963008146	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
1118963008147	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1118963008148	active site
1118963008149	HIGH motif; other site
1118963008150	KMSKS motif; other site
1118963008151	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1118963008152	tRNA binding surface [nucleotide binding]; other site
1118963008153	anticodon binding site; other site
1118963008154	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963008155	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1118963008156	Walker A/P-loop; other site
1118963008157	ATP binding site [chemical binding]; other site
1118963008158	Q-loop/lid; other site
1118963008159	ABC transporter signature motif; other site
1118963008160	Walker B; other site
1118963008161	D-loop; other site
1118963008162	H-loop/switch region; other site
1118963008163	FtsX-like permease family; Region: FtsX; pfam02687
1118963008164	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1118963008165	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1118963008166	ligand binding site [chemical binding]; other site
1118963008167	NAD binding site [chemical binding]; other site
1118963008168	dimerization interface [polypeptide binding]; other site
1118963008169	catalytic site [active]
1118963008170	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1118963008171	putative L-serine binding site [chemical binding]; other site
1118963008172	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1118963008173	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1118963008174	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1118963008175	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1118963008176	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1118963008177	putative valine binding site [chemical binding]; other site
1118963008178	dimer interface [polypeptide binding]; other site
1118963008179	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1118963008180	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
1118963008181	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1118963008182	PYR/PP interface [polypeptide binding]; other site
1118963008183	dimer interface [polypeptide binding]; other site
1118963008184	TPP binding site [chemical binding]; other site
1118963008185	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1118963008186	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1118963008187	TPP-binding site [chemical binding]; other site
1118963008188	dimer interface [polypeptide binding]; other site
1118963008189	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1118963008190	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963008191	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963008192	putative DNA binding site [nucleotide binding]; other site
1118963008193	putative Zn2+ binding site [ion binding]; other site
1118963008194	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963008195	dimerization interface [polypeptide binding]; other site
1118963008196	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
1118963008197	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
1118963008198	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1118963008199	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963008200	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963008201	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1118963008202	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1118963008203	catalytic triad [active]
1118963008204	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1118963008205	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1118963008206	peptide binding site [polypeptide binding]; other site
1118963008207	malate:quinone oxidoreductase; Validated; Region: PRK05257
1118963008208	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1118963008209	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1118963008210	MMPL family; Region: MMPL; cl14618
1118963008211	MMPL family; Region: MMPL; cl14618
1118963008212	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1118963008213	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963008214	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963008215	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1118963008216	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1118963008217	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907
1118963008218	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
1118963008219	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1118963008220	transmembrane helices; other site
1118963008221	Electron transfer DM13; Region: DM13; pfam10517
1118963008222	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1118963008223	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1118963008224	GtrA-like protein; Region: GtrA; pfam04138
1118963008225	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1118963008226	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963008227	catalytic residue [active]
1118963008228	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543
1118963008229	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1118963008230	dimerization interface [polypeptide binding]; other site
1118963008231	active site
1118963008232	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
1118963008233	L-aspartate oxidase; Provisional; Region: PRK06175
1118963008234	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1118963008235	quinolinate synthetase; Provisional; Region: PRK09375
1118963008236	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1118963008237	nudix motif; other site
1118963008238	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963008239	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963008240	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1118963008241	Spore germination protein; Region: Spore_permease; cl17796
1118963008242	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1118963008243	tetramer interface [polypeptide binding]; other site
1118963008244	TPP-binding site [chemical binding]; other site
1118963008245	heterodimer interface [polypeptide binding]; other site
1118963008246	phosphorylation loop region [posttranslational modification]
1118963008247	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1118963008248	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1118963008249	alpha subunit interface [polypeptide binding]; other site
1118963008250	TPP binding site [chemical binding]; other site
1118963008251	heterodimer interface [polypeptide binding]; other site
1118963008252	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1118963008253	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1118963008254	E3 interaction surface; other site
1118963008255	lipoyl attachment site [posttranslational modification]; other site
1118963008256	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1118963008257	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963008258	catalytic site [active]
1118963008259	Retinoic acid induced 16-like protein; Region: RAI16-like; pfam10257
1118963008260	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1118963008261	active site
1118963008262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963008263	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963008264	putative substrate translocation pore; other site
1118963008265	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963008266	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963008267	putative DNA binding site [nucleotide binding]; other site
1118963008268	dimerization interface [polypeptide binding]; other site
1118963008269	putative Zn2+ binding site [ion binding]; other site
1118963008270	Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703
1118963008271	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963008272	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
1118963008273	AraC-binding-like domain; Region: AraC_binding_2; pfam14525
1118963008274	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963008275	arylsulfatase; Provisional; Region: PRK13759
1118963008276	Sulfatase; Region: Sulfatase; pfam00884
1118963008277	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1118963008278	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1118963008279	Walker A/P-loop; other site
1118963008280	ATP binding site [chemical binding]; other site
1118963008281	Q-loop/lid; other site
1118963008282	ABC transporter signature motif; other site
1118963008283	Walker B; other site
1118963008284	D-loop; other site
1118963008285	H-loop/switch region; other site
1118963008286	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1118963008287	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963008288	dimer interface [polypeptide binding]; other site
1118963008289	conserved gate region; other site
1118963008290	putative PBP binding loops; other site
1118963008291	ABC-ATPase subunit interface; other site
1118963008292	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1118963008293	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1118963008294	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1118963008295	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1118963008296	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1118963008297	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1118963008298	active site
1118963008299	TetR family transcriptional regulator; Provisional; Region: PRK14996
1118963008300	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963008301	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1118963008302	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963008303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963008304	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1118963008305	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963008306	Walker A/P-loop; other site
1118963008307	ATP binding site [chemical binding]; other site
1118963008308	Q-loop/lid; other site
1118963008309	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1118963008310	ABC transporter signature motif; other site
1118963008311	Walker B; other site
1118963008312	D-loop; other site
1118963008313	H-loop/switch region; other site
1118963008314	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1118963008315	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1118963008316	active site
1118963008317	metal binding site [ion binding]; metal-binding site
1118963008318	DNA binding site [nucleotide binding]
1118963008319	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1118963008320	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
1118963008321	amphipathic channel; other site
1118963008322	Asn-Pro-Ala signature motifs; other site
1118963008323	Domain of unknown function (DUF202); Region: DUF202; pfam02656
1118963008324	Domain of unknown function (DUF202); Region: DUF202; cl09954
1118963008325	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1118963008326	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
1118963008327	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
1118963008328	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1118963008329	active site
1118963008330	catalytic site [active]
1118963008331	substrate binding site [chemical binding]; other site
1118963008332	BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533
1118963008333	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1118963008334	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1118963008335	Walker A/P-loop; other site
1118963008336	ATP binding site [chemical binding]; other site
1118963008337	Q-loop/lid; other site
1118963008338	ABC transporter signature motif; other site
1118963008339	Walker B; other site
1118963008340	D-loop; other site
1118963008341	H-loop/switch region; other site
1118963008342	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1118963008343	DNA-binding site [nucleotide binding]; DNA binding site
1118963008344	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1118963008345	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1118963008346	active site
1118963008347	dimerization interface [polypeptide binding]; other site
1118963008348	ribonuclease PH; Reviewed; Region: rph; PRK00173
1118963008349	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1118963008350	hexamer interface [polypeptide binding]; other site
1118963008351	active site
1118963008352	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1118963008353	glutamate racemase; Provisional; Region: PRK00865
1118963008354	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
1118963008355	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
1118963008356	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1118963008357	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
1118963008358	active site
1118963008359	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1118963008360	catalytic triad [active]
1118963008361	conserved cis-peptide bond; other site
1118963008362	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
1118963008363	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963008364	ATP binding site [chemical binding]; other site
1118963008365	putative Mg++ binding site [ion binding]; other site
1118963008366	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
1118963008367	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1118963008368	active site
1118963008369	trimer interface [polypeptide binding]; other site
1118963008370	allosteric site; other site
1118963008371	active site lid [active]
1118963008372	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1118963008373	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
1118963008374	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1118963008375	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1118963008376	Walker A/P-loop; other site
1118963008377	ATP binding site [chemical binding]; other site
1118963008378	Q-loop/lid; other site
1118963008379	ABC transporter signature motif; other site
1118963008380	Walker B; other site
1118963008381	D-loop; other site
1118963008382	H-loop/switch region; other site
1118963008383	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1118963008384	phosphate binding site [ion binding]; other site
1118963008385	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1118963008386	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1118963008387	Tetratricopeptide repeat; Region: TPR_20; pfam14561
1118963008388	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1118963008389	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963008390	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1118963008391	hypothetical protein; Provisional; Region: PRK03298
1118963008392	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1118963008393	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963008394	active site
1118963008395	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1118963008396	DNA-binding site [nucleotide binding]; DNA binding site
1118963008397	RNA-binding motif; other site
1118963008398	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1118963008399	Putative esterase; Region: Esterase; pfam00756
1118963008400	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
1118963008401	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
1118963008402	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1118963008403	gamma subunit interface [polypeptide binding]; other site
1118963008404	epsilon subunit interface [polypeptide binding]; other site
1118963008405	LBP interface [polypeptide binding]; other site
1118963008406	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1118963008407	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1118963008408	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1118963008409	alpha subunit interaction interface [polypeptide binding]; other site
1118963008410	Walker A motif; other site
1118963008411	ATP binding site [chemical binding]; other site
1118963008412	Walker B motif; other site
1118963008413	inhibitor binding site; inhibition site
1118963008414	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1118963008415	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1118963008416	core domain interface [polypeptide binding]; other site
1118963008417	delta subunit interface [polypeptide binding]; other site
1118963008418	epsilon subunit interface [polypeptide binding]; other site
1118963008419	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1118963008420	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1118963008421	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1118963008422	beta subunit interaction interface [polypeptide binding]; other site
1118963008423	Walker A motif; other site
1118963008424	ATP binding site [chemical binding]; other site
1118963008425	Walker B motif; other site
1118963008426	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1118963008427	ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210
1118963008428	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1118963008429	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
1118963008430	ATP synthase subunit C; Region: ATP-synt_C; cl00466
1118963008431	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1118963008432	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1118963008433	Mg++ binding site [ion binding]; other site
1118963008434	putative catalytic motif [active]
1118963008435	substrate binding site [chemical binding]; other site
1118963008436	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1118963008437	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1118963008438	active site
1118963008439	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1118963008440	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1118963008441	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1118963008442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963008443	S-adenosylmethionine binding site [chemical binding]; other site
1118963008444	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1118963008445	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1118963008446	RF-1 domain; Region: RF-1; pfam00472
1118963008447	transcription termination factor Rho; Provisional; Region: PRK12678
1118963008448	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1118963008449	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1118963008450	RNA binding site [nucleotide binding]; other site
1118963008451	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1118963008452	multimer interface [polypeptide binding]; other site
1118963008453	Walker A motif; other site
1118963008454	ATP binding site [chemical binding]; other site
1118963008455	Walker B motif; other site
1118963008456	homoserine kinase; Provisional; Region: PRK01212
1118963008457	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1118963008458	homodimer interface [polypeptide binding]; other site
1118963008459	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963008460	catalytic residue [active]
1118963008461	homoserine dehydrogenase; Provisional; Region: PRK06349
1118963008462	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1118963008463	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1118963008464	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1118963008465	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1118963008466	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1118963008467	active site
1118963008468	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1118963008469	substrate binding site [chemical binding]; other site
1118963008470	catalytic residues [active]
1118963008471	dimer interface [polypeptide binding]; other site
1118963008472	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1118963008473	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1118963008474	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1118963008475	active site
1118963008476	HIGH motif; other site
1118963008477	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1118963008478	KMSK motif region; other site
1118963008479	tRNA binding surface [nucleotide binding]; other site
1118963008480	DALR anticodon binding domain; Region: DALR_1; smart00836
1118963008481	anticodon binding site; other site
1118963008482	FMN-binding domain; Region: FMN_bind; cl01081
1118963008483	ApbE family; Region: ApbE; pfam02424
1118963008484	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
1118963008485	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
1118963008486	FAD binding pocket [chemical binding]; other site
1118963008487	conserved FAD binding motif [chemical binding]; other site
1118963008488	phosphate binding motif [ion binding]; other site
1118963008489	beta-alpha-beta structure motif; other site
1118963008490	NAD binding pocket [chemical binding]; other site
1118963008491	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1118963008492	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1118963008493	active site
1118963008494	Zn binding site [ion binding]; other site
1118963008495	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1118963008496	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1118963008497	conserved cys residue [active]
1118963008498	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963008499	Predicted transcriptional regulator [Transcription]; Region: COG2378
1118963008500	HTH domain; Region: HTH_11; pfam08279
1118963008501	WYL domain; Region: WYL; pfam13280
1118963008502	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
1118963008503	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963008504	ATP binding site [chemical binding]; other site
1118963008505	putative Mg++ binding site [ion binding]; other site
1118963008506	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963008507	nucleotide binding region [chemical binding]; other site
1118963008508	ATP-binding site [chemical binding]; other site
1118963008509	Helicase associated domain (HA2); Region: HA2; pfam04408
1118963008510	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1118963008511	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1118963008512	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1118963008513	nucleotide binding site/active site [active]
1118963008514	HIT family signature motif; other site
1118963008515	catalytic residue [active]
1118963008516	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1118963008517	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1118963008518	putative NAD(P) binding site [chemical binding]; other site
1118963008519	putative substrate binding site [chemical binding]; other site
1118963008520	catalytic Zn binding site [ion binding]; other site
1118963008521	structural Zn binding site [ion binding]; other site
1118963008522	dimer interface [polypeptide binding]; other site
1118963008523	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1118963008524	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1118963008525	active site residue [active]
1118963008526	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1118963008527	active site residue [active]
1118963008528	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1118963008529	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963008530	catalytic residue [active]
1118963008531	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1118963008532	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1118963008533	metal binding site 2 [ion binding]; metal-binding site
1118963008534	putative DNA binding helix; other site
1118963008535	metal binding site 1 [ion binding]; metal-binding site
1118963008536	dimer interface [polypeptide binding]; other site
1118963008537	structural Zn2+ binding site [ion binding]; other site
1118963008538	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1118963008539	dimer interface [polypeptide binding]; other site
1118963008540	putative PBP binding regions; other site
1118963008541	ABC-ATPase subunit  interface; other site
1118963008542	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1118963008543	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1118963008544	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1118963008545	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1118963008546	intersubunit interface [polypeptide binding]; other site
1118963008547	Domain of unknown function DUF21; Region: DUF21; pfam01595
1118963008548	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1118963008549	FOG: CBS domain [General function prediction only]; Region: COG0517
1118963008550	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1118963008551	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1118963008552	Domain of unknown function DUF21; Region: DUF21; pfam01595
1118963008553	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1118963008554	Transporter associated domain; Region: CorC_HlyC; smart01091
1118963008555	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
1118963008556	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1118963008557	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1118963008558	TPP-binding site [chemical binding]; other site
1118963008559	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1118963008560	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1118963008561	active site
1118963008562	catalytic triad [active]
1118963008563	oxyanion hole [active]
1118963008564	Beta-lactamase; Region: Beta-lactamase; pfam00144
1118963008565	Uncharacterized conserved protein [Function unknown]; Region: COG3595
1118963008566	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1118963008567	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1118963008568	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
1118963008569	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
1118963008570	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963008571	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1118963008572	DNA binding residues [nucleotide binding]
1118963008573	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1118963008574	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1118963008575	hinge; other site
1118963008576	active site
1118963008577	Predicted GTPases [General function prediction only]; Region: COG1162
1118963008578	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1118963008579	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1118963008580	GTP/Mg2+ binding site [chemical binding]; other site
1118963008581	G4 box; other site
1118963008582	G5 box; other site
1118963008583	G1 box; other site
1118963008584	Switch I region; other site
1118963008585	G2 box; other site
1118963008586	G3 box; other site
1118963008587	Switch II region; other site
1118963008588	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1118963008589	active site
1118963008590	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
1118963008591	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963008592	catalytic residue [active]
1118963008593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1118963008594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963008595	S-adenosylmethionine binding site [chemical binding]; other site
1118963008596	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1118963008597	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1118963008598	Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
1118963008599	FeoA domain; Region: FeoA; pfam04023
1118963008600	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963008601	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963008602	putative substrate translocation pore; other site
1118963008603	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1118963008604	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1118963008605	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1118963008606	protein binding site [polypeptide binding]; other site
1118963008607	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1118963008608	SmpB-tmRNA interface; other site
1118963008609	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
1118963008610	Peptidase family M23; Region: Peptidase_M23; pfam01551
1118963008611	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1118963008612	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1118963008613	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1118963008614	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963008615	Walker A/P-loop; other site
1118963008616	ATP binding site [chemical binding]; other site
1118963008617	Q-loop/lid; other site
1118963008618	ABC transporter signature motif; other site
1118963008619	Walker B; other site
1118963008620	D-loop; other site
1118963008621	H-loop/switch region; other site
1118963008622	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1118963008623	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1118963008624	RF-1 domain; Region: RF-1; pfam00472
1118963008625	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1118963008626	TadE-like protein; Region: TadE; pfam07811
1118963008627	Type II secretion system (T2SS), protein F; Region: T2SF; cl19503
1118963008628	Type II secretion system (T2SS), protein F; Region: T2SF; cl19503
1118963008629	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1118963008630	Walker A motif; other site
1118963008631	ATP binding site [chemical binding]; other site
1118963008632	Walker B motif; other site
1118963008633	Type III secretion protein (HpaP); Region: HpaP; cl17849
1118963008634	CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans.  CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412
1118963008635	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1118963008636	active site
1118963008637	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963008638	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963008639	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13906
1118963008640	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1118963008641	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
1118963008642	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
1118963008643	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963008644	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963008645	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963008646	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963008647	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1118963008648	active site
1118963008649	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1118963008650	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
1118963008651	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
1118963008652	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1118963008653	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1118963008654	Walker A/P-loop; other site
1118963008655	ATP binding site [chemical binding]; other site
1118963008656	Q-loop/lid; other site
1118963008657	ABC transporter signature motif; other site
1118963008658	Walker B; other site
1118963008659	D-loop; other site
1118963008660	H-loop/switch region; other site
1118963008661	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1118963008662	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1118963008663	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1118963008664	active site
1118963008665	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1118963008666	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1118963008667	UDP-galactopyranose mutase; Region: GLF; pfam03275
1118963008668	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963008669	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963008670	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963008671	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1118963008672	inhibitor-cofactor binding pocket; inhibition site
1118963008673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963008674	catalytic residue [active]
1118963008675	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1118963008676	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1118963008677	putative trimer interface [polypeptide binding]; other site
1118963008678	putative CoA binding site [chemical binding]; other site
1118963008679	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
1118963008680	putative trimer interface [polypeptide binding]; other site
1118963008681	putative active site [active]
1118963008682	putative substrate binding site [chemical binding]; other site
1118963008683	putative CoA binding site [chemical binding]; other site
1118963008684	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1118963008685	phosphopeptide binding site; other site
1118963008686	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1118963008687	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1118963008688	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1118963008689	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
1118963008690	PAS fold; Region: PAS_4; pfam08448
1118963008691	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1118963008692	Histidine kinase; Region: HisKA_2; pfam07568
1118963008693	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963008694	ATP binding site [chemical binding]; other site
1118963008695	Mg2+ binding site [ion binding]; other site
1118963008696	G-X-G motif; other site
1118963008697	NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902
1118963008698	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1118963008699	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1118963008700	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1118963008701	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1118963008702	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1118963008703	Helix-turn-helix domain; Region: HTH_17; pfam12728
1118963008704	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1118963008705	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1118963008706	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1118963008707	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1118963008708	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963008709	nucleotide binding region [chemical binding]; other site
1118963008710	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
1118963008711	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1118963008712	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1118963008713	30S subunit binding site; other site
1118963008714	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
1118963008715	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1118963008716	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1118963008717	active site
1118963008718	lipoprotein LpqB; Provisional; Region: PRK13614
1118963008719	Sporulation and spore germination; Region: Germane; pfam10646
1118963008720	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1118963008721	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1118963008722	dimerization interface [polypeptide binding]; other site
1118963008723	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1118963008724	dimer interface [polypeptide binding]; other site
1118963008725	phosphorylation site [posttranslational modification]
1118963008726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963008727	ATP binding site [chemical binding]; other site
1118963008728	Mg2+ binding site [ion binding]; other site
1118963008729	G-X-G motif; other site
1118963008730	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1118963008731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963008732	active site
1118963008733	phosphorylation site [posttranslational modification]
1118963008734	intermolecular recognition site; other site
1118963008735	dimerization interface [polypeptide binding]; other site
1118963008736	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1118963008737	DNA binding site [nucleotide binding]
1118963008738	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
1118963008739	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1118963008740	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
1118963008741	MoxR-like ATPases [General function prediction only]; Region: COG0714
1118963008742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963008743	Walker A motif; other site
1118963008744	ATP binding site [chemical binding]; other site
1118963008745	Walker B motif; other site
1118963008746	arginine finger; other site
1118963008747	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
1118963008748	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1118963008749	Protein of unknown function DUF58; Region: DUF58; pfam01882
1118963008750	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
1118963008751	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1118963008752	chorismate mutase; Provisional; Region: PRK09239
1118963008753	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1118963008754	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963008755	Walker A/P-loop; other site
1118963008756	ATP binding site [chemical binding]; other site
1118963008757	Q-loop/lid; other site
1118963008758	ABC transporter signature motif; other site
1118963008759	Walker B; other site
1118963008760	D-loop; other site
1118963008761	H-loop/switch region; other site
1118963008762	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963008763	Walker A/P-loop; other site
1118963008764	ATP binding site [chemical binding]; other site
1118963008765	Q-loop/lid; other site
1118963008766	ABC transporter signature motif; other site
1118963008767	Walker B; other site
1118963008768	D-loop; other site
1118963008769	H-loop/switch region; other site
1118963008770	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1118963008771	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1118963008772	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963008773	dimer interface [polypeptide binding]; other site
1118963008774	conserved gate region; other site
1118963008775	putative PBP binding loops; other site
1118963008776	ABC-ATPase subunit interface; other site
1118963008777	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1118963008778	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963008779	dimer interface [polypeptide binding]; other site
1118963008780	conserved gate region; other site
1118963008781	putative PBP binding loops; other site
1118963008782	ABC-ATPase subunit interface; other site
1118963008783	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1118963008784	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1118963008785	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1118963008786	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1118963008787	Ligand Binding Site [chemical binding]; other site
1118963008788	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1118963008789	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963008790	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963008791	Reductase C-terminal; Region: Reductase_C; pfam14759
1118963008792	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1118963008793	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963008794	catalytic residue [active]
1118963008795	Predicted transcriptional regulator [Transcription]; Region: COG2345
1118963008796	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963008797	putative DNA binding site [nucleotide binding]; other site
1118963008798	dimerization interface [polypeptide binding]; other site
1118963008799	putative Zn2+ binding site [ion binding]; other site
1118963008800	diacylglycerol kinase; Reviewed; Region: PRK11914
1118963008801	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1118963008802	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1118963008803	HSP70 interaction site [polypeptide binding]; other site
1118963008804	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1118963008805	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
1118963008806	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963008807	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1118963008808	DNA binding residues [nucleotide binding]
1118963008809	putative anti-sigmaE protein; Provisional; Region: PRK13920
1118963008810	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1118963008811	GntP family permease; Region: GntP_permease; pfam02447
1118963008812	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1118963008813	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1118963008814	AAA domain; Region: AAA_33; pfam13671
1118963008815	ATP-binding site [chemical binding]; other site
1118963008816	Gluconate-6-phosphate binding site [chemical binding]; other site
1118963008817	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
1118963008818	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1118963008819	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1118963008820	Ligand Binding Site [chemical binding]; other site
1118963008821	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1118963008822	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1118963008823	Ligand binding site [chemical binding]; other site
1118963008824	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1118963008825	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1118963008826	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1118963008827	protein binding site [polypeptide binding]; other site
1118963008828	TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535
1118963008829	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1118963008830	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
1118963008831	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1118963008832	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963008833	DNA-binding site [nucleotide binding]; DNA binding site
1118963008834	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1118963008835	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
1118963008836	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1118963008837	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1118963008838	GET complex subunit GET2; Region: GET2; pfam08690
1118963008839	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
1118963008840	Protein of unknown function DUF45; Region: DUF45; pfam01863
1118963008841	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1118963008842	Part of AAA domain; Region: AAA_19; pfam13245
1118963008843	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
1118963008844	HRDC domain; Region: HRDC; pfam00570
1118963008845	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1118963008846	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1118963008847	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1118963008848	putative NADH binding site [chemical binding]; other site
1118963008849	putative active site [active]
1118963008850	nudix motif; other site
1118963008851	putative metal binding site [ion binding]; other site
1118963008852	Phosphotransferase enzyme family; Region: APH; pfam01636
1118963008853	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1118963008854	active site
1118963008855	ATP binding site [chemical binding]; other site
1118963008856	substrate binding site [chemical binding]; other site
1118963008857	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1118963008858	Part of AAA domain; Region: AAA_19; pfam13245
1118963008859	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
1118963008860	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1118963008861	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1118963008862	Part of AAA domain; Region: AAA_19; pfam13245
1118963008863	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1118963008864	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1118963008865	DNA binding site [nucleotide binding]
1118963008866	active site
1118963008867	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1118963008868	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
1118963008869	active site
1118963008870	catalytic site [active]
1118963008871	substrate binding site [chemical binding]; other site
1118963008872	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1118963008873	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1118963008874	substrate binding pocket [chemical binding]; other site
1118963008875	membrane-bound complex binding site; other site
1118963008876	hinge residues; other site
1118963008877	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1118963008878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963008879	dimer interface [polypeptide binding]; other site
1118963008880	conserved gate region; other site
1118963008881	putative PBP binding loops; other site
1118963008882	ABC-ATPase subunit interface; other site
1118963008883	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1118963008884	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1118963008885	Walker A/P-loop; other site
1118963008886	ATP binding site [chemical binding]; other site
1118963008887	Q-loop/lid; other site
1118963008888	ABC transporter signature motif; other site
1118963008889	Walker B; other site
1118963008890	D-loop; other site
1118963008891	H-loop/switch region; other site
1118963008892	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1118963008893	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1118963008894	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1118963008895	inhibitor-cofactor binding pocket; inhibition site
1118963008896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963008897	catalytic residue [active]
1118963008898	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1118963008899	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1118963008900	dimer interface [polypeptide binding]; other site
1118963008901	active site
1118963008902	Schiff base residues; other site
1118963008903	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1118963008904	active site
1118963008905	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1118963008906	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1118963008907	domain interfaces; other site
1118963008908	active site
1118963008909	ferrochelatase; Reviewed; Region: hemH; PRK00035
1118963008910	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1118963008911	C-terminal domain interface [polypeptide binding]; other site
1118963008912	active site
1118963008913	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1118963008914	active site
1118963008915	N-terminal domain interface [polypeptide binding]; other site
1118963008916	Chlorite dismutase; Region: Chlor_dismutase; cl01280
1118963008917	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1118963008918	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1118963008919	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1118963008920	substrate binding site [chemical binding]; other site
1118963008921	active site
1118963008922	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1118963008923	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1118963008924	NAD(P) binding pocket [chemical binding]; other site
1118963008925	Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745
1118963008926	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
1118963008927	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1118963008928	ATP binding site [chemical binding]; other site
1118963008929	substrate interface [chemical binding]; other site
1118963008930	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1118963008931	active site residue [active]
1118963008932	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963008933	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963008934	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
1118963008935	Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329
1118963008936	DCoH dimer interaction site [polypeptide binding]; other site
1118963008937	substrate binding site [chemical binding]; other site
1118963008938	aromatic arch; other site
1118963008939	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1118963008940	ThiS interaction site; other site
1118963008941	putative active site [active]
1118963008942	tetramer interface [polypeptide binding]; other site
1118963008943	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1118963008944	thiS-thiF/thiG interaction site; other site
1118963008945	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1118963008946	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963008947	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1118963008948	thiamine phosphate binding site [chemical binding]; other site
1118963008949	active site
1118963008950	pyrophosphate binding site [ion binding]; other site
1118963008951	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794
1118963008952	TM2 domain; Region: TM2; pfam05154
1118963008953	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1118963008954	RNB domain; Region: RNB; pfam00773
1118963008955	helicase 45; Provisional; Region: PTZ00424
1118963008956	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1118963008957	ATP binding site [chemical binding]; other site
1118963008958	Mg++ binding site [ion binding]; other site
1118963008959	motif III; other site
1118963008960	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963008961	nucleotide binding region [chemical binding]; other site
1118963008962	ATP-binding site [chemical binding]; other site
1118963008963	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1118963008964	DNA methylase; Region: N6_N4_Mtase; pfam01555
1118963008965	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
1118963008966	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
1118963008967	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1118963008968	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1118963008969	active site
1118963008970	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
1118963008971	proline aminopeptidase P II; Provisional; Region: PRK10879
1118963008972	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1118963008973	active site
1118963008974	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1118963008975	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1118963008976	PRC-barrel domain; Region: PRC; pfam05239
1118963008977	MgtE intracellular N domain; Region: MgtE_N; smart00924
1118963008978	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1118963008979	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
1118963008980	Domain of unknown function DUF59; Region: DUF59; cl00941
1118963008981	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1118963008982	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1118963008983	Walker A motif; other site
1118963008984	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1118963008985	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
1118963008986	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
1118963008987	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963008988	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1118963008989	DNA binding residues [nucleotide binding]
1118963008990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963008991	S-adenosylmethionine binding site [chemical binding]; other site
1118963008992	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1118963008993	DivIVA domain; Region: DivI1A_domain; TIGR03544
1118963008994	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1118963008995	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1118963008996	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1118963008997	Walker A/P-loop; other site
1118963008998	ATP binding site [chemical binding]; other site
1118963008999	Q-loop/lid; other site
1118963009000	ABC transporter signature motif; other site
1118963009001	Walker B; other site
1118963009002	D-loop; other site
1118963009003	H-loop/switch region; other site
1118963009004	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1118963009005	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1118963009006	substrate binding pocket [chemical binding]; other site
1118963009007	membrane-bound complex binding site; other site
1118963009008	hinge residues; other site
1118963009009	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1118963009010	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009011	dimer interface [polypeptide binding]; other site
1118963009012	conserved gate region; other site
1118963009013	putative PBP binding loops; other site
1118963009014	ABC-ATPase subunit interface; other site
1118963009015	ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160
1118963009016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009017	dimer interface [polypeptide binding]; other site
1118963009018	conserved gate region; other site
1118963009019	putative PBP binding loops; other site
1118963009020	ABC-ATPase subunit interface; other site
1118963009021	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
1118963009022	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
1118963009023	metal binding site [ion binding]; metal-binding site
1118963009024	putative dimer interface [polypeptide binding]; other site
1118963009025	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1118963009026	Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789
1118963009027	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
1118963009028	putative trimer interface [polypeptide binding]; other site
1118963009029	putative CoA binding site [chemical binding]; other site
1118963009030	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963009031	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1118963009032	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1118963009033	UDP-glucose 4-epimerase; Region: PLN02240
1118963009034	NAD binding site [chemical binding]; other site
1118963009035	homodimer interface [polypeptide binding]; other site
1118963009036	active site
1118963009037	substrate binding site [chemical binding]; other site
1118963009038	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1118963009039	dimer interface [polypeptide binding]; other site
1118963009040	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1118963009041	active site
1118963009042	citrylCoA binding site [chemical binding]; other site
1118963009043	NADH binding [chemical binding]; other site
1118963009044	cationic pore residues; other site
1118963009045	oxalacetate/citrate binding site [chemical binding]; other site
1118963009046	coenzyme A binding site [chemical binding]; other site
1118963009047	catalytic triad [active]
1118963009048	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
1118963009049	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963009050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963009051	homodimer interface [polypeptide binding]; other site
1118963009052	catalytic residue [active]
1118963009053	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1118963009054	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
1118963009055	G1 box; other site
1118963009056	putative GEF interaction site [polypeptide binding]; other site
1118963009057	GTP/Mg2+ binding site [chemical binding]; other site
1118963009058	Switch I region; other site
1118963009059	G2 box; other site
1118963009060	G3 box; other site
1118963009061	Switch II region; other site
1118963009062	G4 box; other site
1118963009063	G5 box; other site
1118963009064	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1118963009065	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1118963009066	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1118963009067	active site
1118963009068	catalytic triad [active]
1118963009069	oxyanion hole [active]
1118963009070	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1118963009071	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963009072	Walker A/P-loop; other site
1118963009073	ATP binding site [chemical binding]; other site
1118963009074	Q-loop/lid; other site
1118963009075	ABC transporter signature motif; other site
1118963009076	Walker B; other site
1118963009077	D-loop; other site
1118963009078	H-loop/switch region; other site
1118963009079	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1118963009080	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963009081	Walker A/P-loop; other site
1118963009082	ATP binding site [chemical binding]; other site
1118963009083	Q-loop/lid; other site
1118963009084	ABC transporter signature motif; other site
1118963009085	Walker B; other site
1118963009086	D-loop; other site
1118963009087	H-loop/switch region; other site
1118963009088	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1118963009089	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1118963009090	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1118963009091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009092	dimer interface [polypeptide binding]; other site
1118963009093	conserved gate region; other site
1118963009094	putative PBP binding loops; other site
1118963009095	ABC-ATPase subunit interface; other site
1118963009096	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1118963009097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009098	dimer interface [polypeptide binding]; other site
1118963009099	conserved gate region; other site
1118963009100	putative PBP binding loops; other site
1118963009101	ABC-ATPase subunit interface; other site
1118963009102	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1118963009103	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1118963009104	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
1118963009105	GTP/Mg2+ binding site [chemical binding]; other site
1118963009106	G5 box; other site
1118963009107	GTP-binding protein YchF; Reviewed; Region: PRK09601
1118963009108	YchF GTPase; Region: YchF; cd01900
1118963009109	G1 box; other site
1118963009110	G1 box; other site
1118963009111	GTP/Mg2+ binding site [chemical binding]; other site
1118963009112	Switch I region; other site
1118963009113	G2 box; other site
1118963009114	Switch II region; other site
1118963009115	G3 box; other site
1118963009116	G4 box; other site
1118963009117	G5 box; other site
1118963009118	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1118963009119	RmuC family; Region: RmuC; pfam02646
1118963009120	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
1118963009121	Fe-S cluster binding site [ion binding]; other site
1118963009122	substrate binding site [chemical binding]; other site
1118963009123	catalytic site [active]
1118963009124	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
1118963009125	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
1118963009126	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1118963009127	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1118963009128	generic binding surface II; other site
1118963009129	generic binding surface I; other site
1118963009130	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1118963009131	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
1118963009132	aminotransferase AlaT; Validated; Region: PRK09265
1118963009133	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963009134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963009135	homodimer interface [polypeptide binding]; other site
1118963009136	catalytic residue [active]
1118963009137	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1118963009138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009139	dimer interface [polypeptide binding]; other site
1118963009140	conserved gate region; other site
1118963009141	putative PBP binding loops; other site
1118963009142	ABC-ATPase subunit interface; other site
1118963009143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009144	dimer interface [polypeptide binding]; other site
1118963009145	conserved gate region; other site
1118963009146	putative PBP binding loops; other site
1118963009147	ABC-ATPase subunit interface; other site
1118963009148	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1118963009149	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963009150	Walker A/P-loop; other site
1118963009151	ATP binding site [chemical binding]; other site
1118963009152	Q-loop/lid; other site
1118963009153	ABC transporter signature motif; other site
1118963009154	Walker B; other site
1118963009155	D-loop; other site
1118963009156	H-loop/switch region; other site
1118963009157	Dehydratase medium subunit; Region: Dehydratase_MU; cl17703
1118963009158	GTPase RsgA; Reviewed; Region: PRK01889
1118963009159	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1118963009160	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1118963009161	GTP/Mg2+ binding site [chemical binding]; other site
1118963009162	G4 box; other site
1118963009163	G5 box; other site
1118963009164	G1 box; other site
1118963009165	Switch I region; other site
1118963009166	G2 box; other site
1118963009167	G3 box; other site
1118963009168	Switch II region; other site
1118963009169	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1118963009170	nudix motif; other site
1118963009171	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
1118963009172	Pirin-related protein [General function prediction only]; Region: COG1741
1118963009173	Pirin; Region: Pirin; pfam02678
1118963009174	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1118963009175	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963009176	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1118963009177	Nitronate monooxygenase; Region: NMO; pfam03060
1118963009178	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1118963009179	FMN binding site [chemical binding]; other site
1118963009180	substrate binding site [chemical binding]; other site
1118963009181	putative catalytic residue [active]
1118963009182	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963009183	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963009184	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1118963009185	putative dimerization interface [polypeptide binding]; other site
1118963009186	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963009187	putative substrate translocation pore; other site
1118963009188	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1118963009189	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
1118963009190	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963009191	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1118963009192	putative DNA binding site [nucleotide binding]; other site
1118963009193	putative Zn2+ binding site [ion binding]; other site
1118963009194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963009195	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963009196	putative substrate translocation pore; other site
1118963009197	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963009198	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963009199	dimerization interface [polypeptide binding]; other site
1118963009200	putative DNA binding site [nucleotide binding]; other site
1118963009201	putative Zn2+ binding site [ion binding]; other site
1118963009202	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
1118963009203	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1118963009204	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1118963009205	oligomer interface [polypeptide binding]; other site
1118963009206	metal binding site [ion binding]; metal-binding site
1118963009207	metal binding site [ion binding]; metal-binding site
1118963009208	putative Cl binding site [ion binding]; other site
1118963009209	basic sphincter; other site
1118963009210	hydrophobic gate; other site
1118963009211	periplasmic entrance; other site
1118963009212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963009213	Walker A motif; other site
1118963009214	ATP binding site [chemical binding]; other site
1118963009215	Walker B motif; other site
1118963009216	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1118963009217	Ferritin-like domain; Region: Ferritin; pfam00210
1118963009218	ferroxidase diiron center [ion binding]; other site
1118963009219	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1118963009220	CrcB-like protein; Region: CRCB; pfam02537
1118963009221	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963009222	Ligand Binding Site [chemical binding]; other site
1118963009223	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1118963009224	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1118963009225	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963009226	putative DNA binding site [nucleotide binding]; other site
1118963009227	putative Zn2+ binding site [ion binding]; other site
1118963009228	Predicted transcriptional regulators [Transcription]; Region: COG1695
1118963009229	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
1118963009230	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
1118963009231	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1118963009232	Catalytic site [active]
1118963009233	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1118963009234	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963009235	NAD(P) binding site [chemical binding]; other site
1118963009236	active site
1118963009237	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1118963009238	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1118963009239	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1118963009240	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1118963009241	active site
1118963009242	tetramer interface; other site
1118963009243	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
1118963009244	Zinc ribbon domain; Region: Zn-ribbon_8; cl00993
1118963009245	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1118963009246	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
1118963009247	Part of AAA domain; Region: AAA_19; pfam13245
1118963009248	GMP synthase; Reviewed; Region: guaA; PRK00074
1118963009249	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1118963009250	AMP/PPi binding site [chemical binding]; other site
1118963009251	candidate oxyanion hole; other site
1118963009252	catalytic triad [active]
1118963009253	potential glutamine specificity residues [chemical binding]; other site
1118963009254	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1118963009255	ATP Binding subdomain [chemical binding]; other site
1118963009256	Ligand Binding sites [chemical binding]; other site
1118963009257	Dimerization subdomain; other site
1118963009258	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1118963009259	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1118963009260	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1118963009261	active site
1118963009262	phosphorylation site [posttranslational modification]
1118963009263	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1118963009264	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963009265	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1118963009266	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
1118963009267	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1118963009268	active site
1118963009269	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1118963009270	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963009271	Walker A/P-loop; other site
1118963009272	ATP binding site [chemical binding]; other site
1118963009273	Q-loop/lid; other site
1118963009274	ABC transporter signature motif; other site
1118963009275	Walker B; other site
1118963009276	D-loop; other site
1118963009277	H-loop/switch region; other site
1118963009278	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1118963009279	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1118963009280	active site
1118963009281	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1118963009282	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1118963009283	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1118963009284	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1118963009285	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1118963009286	Uncharacterized conserved protein [Function unknown]; Region: COG4095
1118963009287	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963009288	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963009289	DNA binding residues [nucleotide binding]
1118963009290	dimerization interface [polypeptide binding]; other site
1118963009291	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
1118963009292	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1118963009293	ring oligomerisation interface [polypeptide binding]; other site
1118963009294	ATP/Mg binding site [chemical binding]; other site
1118963009295	stacking interactions; other site
1118963009296	hinge regions; other site
1118963009297	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1118963009298	oligomerisation interface [polypeptide binding]; other site
1118963009299	mobile loop; other site
1118963009300	roof hairpin; other site
1118963009301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963009302	S-adenosylmethionine binding site [chemical binding]; other site
1118963009303	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
1118963009304	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1118963009305	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1118963009306	shikimate binding site; other site
1118963009307	NAD(P) binding site [chemical binding]; other site
1118963009308	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1118963009309	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1118963009310	carboxylate-amine ligase; Provisional; Region: PRK13517
1118963009311	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1118963009312	UGMP family protein; Validated; Region: PRK09604
1118963009313	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1118963009314	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1118963009315	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963009316	Coenzyme A binding pocket [chemical binding]; other site
1118963009317	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1118963009318	Glycoprotease family; Region: Peptidase_M22; pfam00814
1118963009319	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
1118963009320	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1118963009321	alanine racemase; Reviewed; Region: alr; PRK00053
1118963009322	active site
1118963009323	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1118963009324	dimer interface [polypeptide binding]; other site
1118963009325	substrate binding site [chemical binding]; other site
1118963009326	catalytic residues [active]
1118963009327	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1118963009328	substrate binding site [chemical binding]; other site
1118963009329	ATP binding site [chemical binding]; other site
1118963009330	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1118963009331	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
1118963009332	NAD binding site [chemical binding]; other site
1118963009333	sugar binding site [chemical binding]; other site
1118963009334	divalent metal binding site [ion binding]; other site
1118963009335	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1118963009336	dimer interface [polypeptide binding]; other site
1118963009337	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1118963009338	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1118963009339	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1118963009340	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1118963009341	putative ADP-binding pocket [chemical binding]; other site
1118963009342	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1118963009343	Potassium binding sites [ion binding]; other site
1118963009344	Cesium cation binding sites [ion binding]; other site
1118963009345	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
1118963009346	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963009347	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963009348	active site
1118963009349	catalytic tetrad [active]
1118963009350	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
1118963009351	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1118963009352	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1118963009353	catalytic site [active]
1118963009354	active site
1118963009355	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1118963009356	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
1118963009357	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1118963009358	active site
1118963009359	catalytic site [active]
1118963009360	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1118963009361	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1118963009362	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1118963009363	active site
1118963009364	catalytic site [active]
1118963009365	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1118963009366	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1118963009367	putative substrate binding site [chemical binding]; other site
1118963009368	putative ATP binding site [chemical binding]; other site
1118963009369	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1118963009370	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1118963009371	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1118963009372	glutaminase active site [active]
1118963009373	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1118963009374	dimer interface [polypeptide binding]; other site
1118963009375	active site
1118963009376	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1118963009377	dimer interface [polypeptide binding]; other site
1118963009378	active site
1118963009379	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1118963009380	ATP-binding site [chemical binding]; other site
1118963009381	CoA-binding site [chemical binding]; other site
1118963009382	Mg2+-binding site [ion binding]; other site
1118963009383	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1118963009384	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
1118963009385	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1118963009386	active site
1118963009387	substrate binding site [chemical binding]; other site
1118963009388	metal binding site [ion binding]; metal-binding site
1118963009389	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1118963009390	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1118963009391	23S rRNA interface [nucleotide binding]; other site
1118963009392	L3 interface [polypeptide binding]; other site
1118963009393	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1118963009394	TadE-like protein; Region: TadE; pfam07811
1118963009395	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1118963009396	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
1118963009397	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
1118963009398	cell division inhibitor MinD; Provisional; Region: PRK10818
1118963009399	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1118963009400	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1118963009401	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1118963009402	ATP binding site [chemical binding]; other site
1118963009403	Walker A motif; other site
1118963009404	hexamer interface [polypeptide binding]; other site
1118963009405	Walker B motif; other site
1118963009406	Type II secretion system (T2SS), protein F; Region: T2SF; cl19503
1118963009407	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1118963009408	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1118963009409	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1118963009410	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1118963009411	dimerization interface 3.5A [polypeptide binding]; other site
1118963009412	active site
1118963009413	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1118963009414	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1118963009415	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1118963009416	alphaNTD homodimer interface [polypeptide binding]; other site
1118963009417	alphaNTD - beta interaction site [polypeptide binding]; other site
1118963009418	alphaNTD - beta' interaction site [polypeptide binding]; other site
1118963009419	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1118963009420	30S ribosomal protein S11; Validated; Region: PRK05309
1118963009421	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1118963009422	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1118963009423	rRNA binding site [nucleotide binding]; other site
1118963009424	predicted 30S ribosome binding site; other site
1118963009425	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1118963009426	putative active site pocket [active]
1118963009427	cleavage site
1118963009428	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963009429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009430	dimer interface [polypeptide binding]; other site
1118963009431	conserved gate region; other site
1118963009432	putative PBP binding loops; other site
1118963009433	ABC-ATPase subunit interface; other site
1118963009434	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963009435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009436	dimer interface [polypeptide binding]; other site
1118963009437	conserved gate region; other site
1118963009438	putative PBP binding loops; other site
1118963009439	ABC-ATPase subunit interface; other site
1118963009440	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963009441	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1118963009442	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1118963009443	active site
1118963009444	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1118963009445	adenylate kinase; Reviewed; Region: adk; PRK00279
1118963009446	AMP-binding site [chemical binding]; other site
1118963009447	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1118963009448	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1118963009449	SecY translocase; Region: SecY; pfam00344
1118963009450	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1118963009451	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1118963009452	23S rRNA binding site [nucleotide binding]; other site
1118963009453	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1118963009454	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1118963009455	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1118963009456	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1118963009457	23S rRNA interface [nucleotide binding]; other site
1118963009458	L21e interface [polypeptide binding]; other site
1118963009459	5S rRNA interface [nucleotide binding]; other site
1118963009460	L27 interface [polypeptide binding]; other site
1118963009461	L5 interface [polypeptide binding]; other site
1118963009462	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1118963009463	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1118963009464	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1118963009465	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1118963009466	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1118963009467	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1118963009468	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1118963009469	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1118963009470	RNA binding site [nucleotide binding]; other site
1118963009471	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1118963009472	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1118963009473	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1118963009474	23S rRNA interface [nucleotide binding]; other site
1118963009475	putative translocon interaction site; other site
1118963009476	signal recognition particle (SRP54) interaction site; other site
1118963009477	L23 interface [polypeptide binding]; other site
1118963009478	trigger factor interaction site; other site
1118963009479	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1118963009480	23S rRNA interface [nucleotide binding]; other site
1118963009481	5S rRNA interface [nucleotide binding]; other site
1118963009482	putative antibiotic binding site [chemical binding]; other site
1118963009483	L25 interface [polypeptide binding]; other site
1118963009484	L27 interface [polypeptide binding]; other site
1118963009485	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1118963009486	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1118963009487	G-X-X-G motif; other site
1118963009488	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1118963009489	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1118963009490	putative translocon binding site; other site
1118963009491	protein-rRNA interface [nucleotide binding]; other site
1118963009492	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1118963009493	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1118963009494	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1118963009495	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1118963009496	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1118963009497	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1118963009498	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1118963009499	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1118963009500	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1118963009501	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
1118963009502	elongation factor Tu; Reviewed; Region: PRK00049
1118963009503	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1118963009504	G1 box; other site
1118963009505	GEF interaction site [polypeptide binding]; other site
1118963009506	GTP/Mg2+ binding site [chemical binding]; other site
1118963009507	Switch I region; other site
1118963009508	G2 box; other site
1118963009509	G3 box; other site
1118963009510	Switch II region; other site
1118963009511	G4 box; other site
1118963009512	G5 box; other site
1118963009513	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1118963009514	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1118963009515	Antibiotic Binding Site [chemical binding]; other site
1118963009516	elongation factor G; Reviewed; Region: PRK00007
1118963009517	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1118963009518	G1 box; other site
1118963009519	putative GEF interaction site [polypeptide binding]; other site
1118963009520	GTP/Mg2+ binding site [chemical binding]; other site
1118963009521	Switch I region; other site
1118963009522	G2 box; other site
1118963009523	G3 box; other site
1118963009524	Switch II region; other site
1118963009525	G4 box; other site
1118963009526	G5 box; other site
1118963009527	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1118963009528	Elongation Factor G, domain II; Region: EFG_II; pfam14492
1118963009529	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1118963009530	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1118963009531	30S ribosomal protein S7; Validated; Region: PRK05302
1118963009532	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1118963009533	S17 interaction site [polypeptide binding]; other site
1118963009534	S8 interaction site; other site
1118963009535	16S rRNA interaction site [nucleotide binding]; other site
1118963009536	streptomycin interaction site [chemical binding]; other site
1118963009537	23S rRNA interaction site [nucleotide binding]; other site
1118963009538	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1118963009539	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1118963009540	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
1118963009541	beta and beta' interface [polypeptide binding]; other site
1118963009542	beta' and sigma factor interface [polypeptide binding]; other site
1118963009543	Zn-binding [ion binding]; other site
1118963009544	active site region [active]
1118963009545	catalytic site [active]
1118963009546	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1118963009547	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1118963009548	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1118963009549	G-loop; other site
1118963009550	DNA binding site [nucleotide binding]
1118963009551	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1118963009552	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1118963009553	RPB12 interaction site [polypeptide binding]; other site
1118963009554	RPB1 interaction site [polypeptide binding]; other site
1118963009555	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
1118963009556	RPB10 interaction site [polypeptide binding]; other site
1118963009557	RPB11 interaction site [polypeptide binding]; other site
1118963009558	RPB3 interaction site [polypeptide binding]; other site
1118963009559	putative acyltransferase; Provisional; Region: PRK05790
1118963009560	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1118963009561	dimer interface [polypeptide binding]; other site
1118963009562	active site
1118963009563	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
1118963009564	putative deacylase active site [active]
1118963009565	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1118963009566	core dimer interface [polypeptide binding]; other site
1118963009567	peripheral dimer interface [polypeptide binding]; other site
1118963009568	L10 interface [polypeptide binding]; other site
1118963009569	L11 interface [polypeptide binding]; other site
1118963009570	putative EF-Tu interaction site [polypeptide binding]; other site
1118963009571	putative EF-G interaction site [polypeptide binding]; other site
1118963009572	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1118963009573	23S rRNA interface [nucleotide binding]; other site
1118963009574	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1118963009575	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1118963009576	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963009577	Coenzyme A binding pocket [chemical binding]; other site
1118963009578	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963009579	Coenzyme A binding pocket [chemical binding]; other site
1118963009580	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1118963009581	mRNA/rRNA interface [nucleotide binding]; other site
1118963009582	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1118963009583	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1118963009584	23S rRNA interface [nucleotide binding]; other site
1118963009585	L7/L12 interface [polypeptide binding]; other site
1118963009586	putative thiostrepton binding site; other site
1118963009587	L25 interface [polypeptide binding]; other site
1118963009588	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1118963009589	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1118963009590	putative homodimer interface [polypeptide binding]; other site
1118963009591	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1118963009592	heterodimer interface [polypeptide binding]; other site
1118963009593	homodimer interface [polypeptide binding]; other site
1118963009594	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1118963009595	aspartate aminotransferase; Provisional; Region: PRK05764
1118963009596	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963009597	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963009598	homodimer interface [polypeptide binding]; other site
1118963009599	catalytic residue [active]
1118963009600	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963009601	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963009602	active site
1118963009603	phosphorylation site [posttranslational modification]
1118963009604	intermolecular recognition site; other site
1118963009605	dimerization interface [polypeptide binding]; other site
1118963009606	UDP-glycosyltransferase family protein; Region: PLN02554
1118963009607	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963009608	DNA binding residues [nucleotide binding]
1118963009609	dimerization interface [polypeptide binding]; other site
1118963009610	PspC domain; Region: PspC; pfam04024
1118963009611	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1118963009612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963009613	ATP binding site [chemical binding]; other site
1118963009614	Mg2+ binding site [ion binding]; other site
1118963009615	G-X-G motif; other site
1118963009616	PspC domain; Region: PspC; pfam04024
1118963009617	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753
1118963009618	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1118963009619	PspC domain; Region: PspC; pfam04024
1118963009620	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
1118963009621	active site
1118963009622	ADP/pyrophosphate binding site [chemical binding]; other site
1118963009623	dimerization interface [polypeptide binding]; other site
1118963009624	allosteric effector site; other site
1118963009625	fructose-1,6-bisphosphate binding site; other site
1118963009626	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1118963009627	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963009628	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963009629	putative substrate translocation pore; other site
1118963009630	Predicted transcriptional regulators [Transcription]; Region: COG1695
1118963009631	putative Zn2+ binding site [ion binding]; other site
1118963009632	putative DNA binding site [nucleotide binding]; other site
1118963009633	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1118963009634	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1118963009635	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1118963009636	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1118963009637	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1118963009638	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1118963009639	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1118963009640	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1118963009641	heme-binding site [chemical binding]; other site
1118963009642	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1118963009643	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1118963009644	DNA binding site [nucleotide binding]
1118963009645	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1118963009646	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963009647	Coenzyme A binding pocket [chemical binding]; other site
1118963009648	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963009649	Coenzyme A binding pocket [chemical binding]; other site
1118963009650	polyphosphate kinase; Provisional; Region: PRK05443
1118963009651	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1118963009652	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1118963009653	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1118963009654	putative domain interface [polypeptide binding]; other site
1118963009655	putative active site [active]
1118963009656	catalytic site [active]
1118963009657	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1118963009658	putative domain interface [polypeptide binding]; other site
1118963009659	putative active site [active]
1118963009660	catalytic site [active]
1118963009661	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1118963009662	active site
1118963009663	Ap6A binding site [chemical binding]; other site
1118963009664	nudix motif; other site
1118963009665	metal binding site [ion binding]; metal-binding site
1118963009666	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1118963009667	catalytic core [active]
1118963009668	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1118963009669	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1118963009670	dimerization interface [polypeptide binding]; other site
1118963009671	active site
1118963009672	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1118963009673	folate binding site [chemical binding]; other site
1118963009674	NADP+ binding site [chemical binding]; other site
1118963009675	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1118963009676	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
1118963009677	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
1118963009678	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1118963009679	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1118963009680	putative active site [active]
1118963009681	Winged helix DNA-binding domain; Region: HTH_42; pfam06224
1118963009682	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
1118963009683	FAD binding domain; Region: FAD_binding_4; pfam01565
1118963009684	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1118963009685	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963009686	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963009687	putative substrate translocation pore; other site
1118963009688	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
1118963009689	active site
1118963009690	catalytic site [active]
1118963009691	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1118963009692	active site
1118963009693	catalytic site [active]
1118963009694	Protein of unknown function (DUF3188); Region: DUF3188; pfam11384
1118963009695	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
1118963009696	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1118963009697	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1118963009698	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1118963009699	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1118963009700	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1118963009701	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1118963009702	Walker A/P-loop; other site
1118963009703	ATP binding site [chemical binding]; other site
1118963009704	Q-loop/lid; other site
1118963009705	ABC transporter signature motif; other site
1118963009706	Walker B; other site
1118963009707	D-loop; other site
1118963009708	H-loop/switch region; other site
1118963009709	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1118963009710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009711	dimer interface [polypeptide binding]; other site
1118963009712	conserved gate region; other site
1118963009713	putative PBP binding loops; other site
1118963009714	ABC-ATPase subunit interface; other site
1118963009715	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1118963009716	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1118963009717	active site
1118963009718	iron coordination sites [ion binding]; other site
1118963009719	substrate binding pocket [chemical binding]; other site
1118963009720	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963009721	active site
1118963009722	catalytic tetrad [active]
1118963009723	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1118963009724	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
1118963009725	active site
1118963009726	catalytic site [active]
1118963009727	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963009728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009729	dimer interface [polypeptide binding]; other site
1118963009730	conserved gate region; other site
1118963009731	putative PBP binding loops; other site
1118963009732	ABC-ATPase subunit interface; other site
1118963009733	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963009734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009735	dimer interface [polypeptide binding]; other site
1118963009736	conserved gate region; other site
1118963009737	putative PBP binding loops; other site
1118963009738	ABC-ATPase subunit interface; other site
1118963009739	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963009740	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963009741	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963009742	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1118963009743	nucleotide binding site [chemical binding]; other site
1118963009744	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1118963009745	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1118963009746	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1118963009747	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963009748	NAD(P) binding site [chemical binding]; other site
1118963009749	putative active site [active]
1118963009750	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1118963009751	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1118963009752	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
1118963009753	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1118963009754	ATP binding site [chemical binding]; other site
1118963009755	Mg++ binding site [ion binding]; other site
1118963009756	motif III; other site
1118963009757	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963009758	nucleotide binding region [chemical binding]; other site
1118963009759	ATP-binding site [chemical binding]; other site
1118963009760	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1118963009761	putative RNA binding site [nucleotide binding]; other site
1118963009762	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1118963009763	MOSC domain; Region: MOSC; pfam03473
1118963009764	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1118963009765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963009766	active site
1118963009767	phosphorylation site [posttranslational modification]
1118963009768	intermolecular recognition site; other site
1118963009769	dimerization interface [polypeptide binding]; other site
1118963009770	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1118963009771	DNA binding site [nucleotide binding]
1118963009772	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1118963009773	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1118963009774	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1118963009775	dimer interface [polypeptide binding]; other site
1118963009776	phosphorylation site [posttranslational modification]
1118963009777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963009778	ATP binding site [chemical binding]; other site
1118963009779	Mg2+ binding site [ion binding]; other site
1118963009780	G-X-G motif; other site
1118963009781	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1118963009782	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963009783	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1118963009784	acyl-coenzyme A oxidase; Region: PLN02526
1118963009785	active site
1118963009786	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963009787	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963009788	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1118963009789	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963009790	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963009791	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
1118963009792	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009793	dimer interface [polypeptide binding]; other site
1118963009794	conserved gate region; other site
1118963009795	putative PBP binding loops; other site
1118963009796	ABC-ATPase subunit interface; other site
1118963009797	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963009798	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009799	dimer interface [polypeptide binding]; other site
1118963009800	conserved gate region; other site
1118963009801	putative PBP binding loops; other site
1118963009802	ABC-ATPase subunit interface; other site
1118963009803	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
1118963009804	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1118963009805	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1118963009806	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1118963009807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963009808	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963009809	putative substrate translocation pore; other site
1118963009810	Predicted transcriptional regulators [Transcription]; Region: COG1733
1118963009811	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
1118963009812	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1118963009813	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1118963009814	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1118963009815	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1118963009816	homodimer interface [polypeptide binding]; other site
1118963009817	substrate-cofactor binding pocket; other site
1118963009818	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963009819	catalytic residue [active]
1118963009820	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
1118963009821	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1118963009822	dimer interface [polypeptide binding]; other site
1118963009823	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963009824	catalytic residue [active]
1118963009825	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
1118963009826	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1118963009827	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066
1118963009828	minor groove reading motif; other site
1118963009829	helix-hairpin-helix signature motif; other site
1118963009830	substrate binding pocket [chemical binding]; other site
1118963009831	active site
1118963009832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963009833	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1118963009834	Walker A/P-loop; other site
1118963009835	ATP binding site [chemical binding]; other site
1118963009836	Q-loop/lid; other site
1118963009837	ABC transporter signature motif; other site
1118963009838	Walker B; other site
1118963009839	D-loop; other site
1118963009840	H-loop/switch region; other site
1118963009841	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1118963009842	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1118963009843	AMP-binding domain protein; Validated; Region: PRK08315
1118963009844	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1118963009845	acyl-activating enzyme (AAE) consensus motif; other site
1118963009846	putative AMP binding site [chemical binding]; other site
1118963009847	putative active site [active]
1118963009848	putative CoA binding site [chemical binding]; other site
1118963009849	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1118963009850	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1118963009851	catalytic residues [active]
1118963009852	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963009853	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1118963009854	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1118963009855	Walker A/P-loop; other site
1118963009856	ATP binding site [chemical binding]; other site
1118963009857	Q-loop/lid; other site
1118963009858	ABC transporter signature motif; other site
1118963009859	Walker B; other site
1118963009860	D-loop; other site
1118963009861	H-loop/switch region; other site
1118963009862	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1118963009863	active site
1118963009864	Ion channel; Region: Ion_trans_2; pfam07885
1118963009865	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1118963009866	heat shock protein HtpX; Provisional; Region: PRK03072
1118963009867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963009868	H+ Antiporter protein; Region: 2A0121; TIGR00900
1118963009869	putative substrate translocation pore; other site
1118963009870	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1118963009871	metal binding site 2 [ion binding]; metal-binding site
1118963009872	putative DNA binding helix; other site
1118963009873	metal binding site 1 [ion binding]; metal-binding site
1118963009874	structural Zn2+ binding site [ion binding]; other site
1118963009875	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1118963009876	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1118963009877	tetramer interface [polypeptide binding]; other site
1118963009878	heme binding pocket [chemical binding]; other site
1118963009879	NADPH binding site [chemical binding]; other site
1118963009880	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
1118963009881	cationic amino acid transport permease; Region: 2A0303; TIGR00906
1118963009882	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963009883	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1118963009884	Protein of unknown function (DUF779); Region: DUF779; pfam05610
1118963009885	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1118963009886	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1118963009887	NAD binding site [chemical binding]; other site
1118963009888	substrate binding site [chemical binding]; other site
1118963009889	catalytic Zn binding site [ion binding]; other site
1118963009890	tetramer interface [polypeptide binding]; other site
1118963009891	structural Zn binding site [ion binding]; other site
1118963009892	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559
1118963009893	NAD(P) binding site [chemical binding]; other site
1118963009894	catalytic residues [active]
1118963009895	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1118963009896	ferredoxin-NADP+ reductase; Region: PLN02852
1118963009897	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963009898	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1118963009899	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1118963009900	EamA-like transporter family; Region: EamA; cl17759
1118963009901	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1118963009902	substrate binding site [chemical binding]; other site
1118963009903	catalytic residues [active]
1118963009904	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1118963009905	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1118963009906	inhibitor-cofactor binding pocket; inhibition site
1118963009907	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963009908	catalytic residue [active]
1118963009909	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
1118963009910	tetrameric interface [polypeptide binding]; other site
1118963009911	NAD binding site [chemical binding]; other site
1118963009912	catalytic residues [active]
1118963009913	substrate binding site [chemical binding]; other site
1118963009914	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1118963009915	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1118963009916	Class I aldolases; Region: Aldolase_Class_I; cl17187
1118963009917	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1118963009918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963009919	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1118963009920	putative substrate translocation pore; other site
1118963009921	transcriptional regulator NanR; Provisional; Region: PRK03837
1118963009922	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963009923	DNA-binding site [nucleotide binding]; DNA binding site
1118963009924	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1118963009925	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1118963009926	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1118963009927	active site residue [active]
1118963009928	ferredoxin-NADP+ reductase; Region: PLN02852
1118963009929	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963009930	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1118963009931	siroheme synthase; Provisional; Region: cysG; PRK10637
1118963009932	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1118963009933	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1118963009934	active site
1118963009935	SAM binding site [chemical binding]; other site
1118963009936	homodimer interface [polypeptide binding]; other site
1118963009937	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1118963009938	active site
1118963009939	glutaminase; Provisional; Region: PRK00971
1118963009940	HB1, ASXL, restriction endonuclease HTH domain; Region: HARE-HTH; pfam05066
1118963009941	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1118963009942	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1118963009943	RibD C-terminal domain; Region: RibD_C; cl17279
1118963009944	Domain of unknown function (DUF305); Region: DUF305; pfam03713
1118963009945	lipoprotein LpqB; Provisional; Region: PRK13616
1118963009946	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1118963009947	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963009948	dimer interface [polypeptide binding]; other site
1118963009949	conserved gate region; other site
1118963009950	putative PBP binding loops; other site
1118963009951	ABC-ATPase subunit interface; other site
1118963009952	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1118963009953	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1118963009954	Walker A/P-loop; other site
1118963009955	ATP binding site [chemical binding]; other site
1118963009956	Q-loop/lid; other site
1118963009957	ABC transporter signature motif; other site
1118963009958	Walker B; other site
1118963009959	D-loop; other site
1118963009960	H-loop/switch region; other site
1118963009961	NMT1-like family; Region: NMT1_2; pfam13379
1118963009962	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1118963009963	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
1118963009964	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1118963009965	CysD dimerization site [polypeptide binding]; other site
1118963009966	G1 box; other site
1118963009967	putative GEF interaction site [polypeptide binding]; other site
1118963009968	GTP/Mg2+ binding site [chemical binding]; other site
1118963009969	Switch I region; other site
1118963009970	G2 box; other site
1118963009971	G3 box; other site
1118963009972	Switch II region; other site
1118963009973	G4 box; other site
1118963009974	G5 box; other site
1118963009975	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1118963009976	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1118963009977	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1118963009978	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1118963009979	Active Sites [active]
1118963009980	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1118963009981	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1118963009982	Active Sites [active]
1118963009983	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1118963009984	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1118963009985	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
1118963009986	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1118963009987	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
1118963009988	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1118963009989	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1118963009990	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1118963009991	putative active site [active]
1118963009992	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1118963009993	active site
1118963009994	Predicted membrane protein [Function unknown]; Region: COG2860
1118963009995	UPF0126 domain; Region: UPF0126; pfam03458
1118963009996	UPF0126 domain; Region: UPF0126; pfam03458
1118963009997	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1118963009998	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1118963009999	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1118963010000	substrate binding pocket [chemical binding]; other site
1118963010001	chain length determination region; other site
1118963010002	substrate-Mg2+ binding site; other site
1118963010003	catalytic residues [active]
1118963010004	aspartate-rich region 1; other site
1118963010005	active site lid residues [active]
1118963010006	aspartate-rich region 2; other site
1118963010007	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1118963010008	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963010009	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1118963010010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963010011	S-adenosylmethionine binding site [chemical binding]; other site
1118963010012	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
1118963010013	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1118963010014	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1118963010015	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1118963010016	substrate binding pocket [chemical binding]; other site
1118963010017	membrane-bound complex binding site; other site
1118963010018	hinge residues; other site
1118963010019	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1118963010020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963010021	dimer interface [polypeptide binding]; other site
1118963010022	conserved gate region; other site
1118963010023	putative PBP binding loops; other site
1118963010024	ABC-ATPase subunit interface; other site
1118963010025	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1118963010026	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1118963010027	Walker A/P-loop; other site
1118963010028	ATP binding site [chemical binding]; other site
1118963010029	Q-loop/lid; other site
1118963010030	ABC transporter signature motif; other site
1118963010031	Walker B; other site
1118963010032	D-loop; other site
1118963010033	H-loop/switch region; other site
1118963010034	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1118963010035	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1118963010036	dimer interface [polypeptide binding]; other site
1118963010037	tetramer interface [polypeptide binding]; other site
1118963010038	PYR/PP interface [polypeptide binding]; other site
1118963010039	TPP binding site [chemical binding]; other site
1118963010040	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1118963010041	TPP-binding site; other site
1118963010042	SOUL heme-binding protein; Region: SOUL; pfam04832
1118963010043	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
1118963010044	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1118963010045	O-succinylbenzoate synthase; Provisional; Region: PRK02901
1118963010046	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1118963010047	active site
1118963010048	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
1118963010049	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963010050	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963010051	DNA binding site [nucleotide binding]
1118963010052	domain linker motif; other site
1118963010053	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
1118963010054	putative dimerization interface [polypeptide binding]; other site
1118963010055	putative ligand binding site [chemical binding]; other site
1118963010056	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1118963010057	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1118963010058	substrate binding [chemical binding]; other site
1118963010059	active site
1118963010060	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963010061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963010062	dimer interface [polypeptide binding]; other site
1118963010063	conserved gate region; other site
1118963010064	putative PBP binding loops; other site
1118963010065	ABC-ATPase subunit interface; other site
1118963010066	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963010067	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963010068	dimer interface [polypeptide binding]; other site
1118963010069	putative PBP binding loops; other site
1118963010070	ABC-ATPase subunit interface; other site
1118963010071	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963010072	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963010073	PAP2 superfamily; Region: PAP2; pfam01569
1118963010074	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1118963010075	Subtilase family; Region: Peptidase_S8; pfam00082
1118963010076	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
1118963010077	active site
1118963010078	catalytic triad [active]
1118963010079	S-layer homology domain; Region: SLH; pfam00395
1118963010080	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963010081	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963010082	putative substrate translocation pore; other site
1118963010083	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1118963010084	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1118963010085	S-layer homology domain; Region: SLH; pfam00395
1118963010086	S-layer homology domain; Region: SLH; pfam00395
1118963010087	Putative Ig domain; Region: He_PIG; pfam05345
1118963010088	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
1118963010089	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1118963010090	O-Antigen ligase; Region: Wzy_C; pfam04932
1118963010091	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1118963010092	TPR motif; other site
1118963010093	binding surface
1118963010094	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1118963010095	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1118963010096	S-layer homology domain; Region: SLH; pfam00395
1118963010097	S-layer homology domain; Region: SLH; pfam00395
1118963010098	S-layer homology domain; Region: SLH; pfam00395
1118963010099	Cation efflux family; Region: Cation_efflux; cl00316
1118963010100	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963010101	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1118963010102	Domain of unknown function DUF21; Region: DUF21; pfam01595
1118963010103	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1118963010104	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1118963010105	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1118963010106	Domain of unknown function DUF21; Region: DUF21; pfam01595
1118963010107	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1118963010108	S-layer homology domain; Region: SLH; pfam00395
1118963010109	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010110	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1118963010111	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010112	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1118963010113	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010114	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1118963010115	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010116	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010117	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1118963010118	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
1118963010119	Subtilase family; Region: Peptidase_S8; pfam00082
1118963010120	active site
1118963010121	catalytic triad [active]
1118963010122	S-layer homology domain; Region: SLH; pfam00395
1118963010123	S-layer homology domain; Region: SLH; pfam00395
1118963010124	S-layer homology domain; Region: SLH; pfam00395
1118963010125	S-layer homology domain; Region: SLH; pfam00395
1118963010126	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010127	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1118963010128	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010129	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1118963010130	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010131	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010132	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1118963010133	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010134	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010135	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1118963010136	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1118963010137	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
1118963010138	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1118963010139	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1118963010140	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963010141	proteins similar to Escherichia coli yceG; Region: yceG_like; cl18961
1118963010142	Predicted transcriptional regulators [Transcription]; Region: COG1733
1118963010143	dimerization interface [polypeptide binding]; other site
1118963010144	putative DNA binding site [nucleotide binding]; other site
1118963010145	putative Zn2+ binding site [ion binding]; other site
1118963010146	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1118963010147	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1118963010148	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1118963010149	E3 interaction surface; other site
1118963010150	lipoyl attachment site [posttranslational modification]; other site
1118963010151	e3 binding domain; Region: E3_binding; pfam02817
1118963010152	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1118963010153	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1118963010154	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1118963010155	alpha subunit interface [polypeptide binding]; other site
1118963010156	TPP binding site [chemical binding]; other site
1118963010157	heterodimer interface [polypeptide binding]; other site
1118963010158	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1118963010159	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1118963010160	tetramer interface [polypeptide binding]; other site
1118963010161	TPP-binding site [chemical binding]; other site
1118963010162	heterodimer interface [polypeptide binding]; other site
1118963010163	phosphorylation loop region [posttranslational modification]
1118963010164	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963010165	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1118963010166	putative DNA binding site [nucleotide binding]; other site
1118963010167	putative Zn2+ binding site [ion binding]; other site
1118963010168	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1118963010169	putative active site [active]
1118963010170	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1118963010171	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1118963010172	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1118963010173	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1118963010174	Chain length determinant protein; Region: Wzz; pfam02706
1118963010175	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1118963010176	AAA domain; Region: AAA_31; pfam13614
1118963010177	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1118963010178	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
1118963010179	FMN binding site [chemical binding]; other site
1118963010180	dimer interface [polypeptide binding]; other site
1118963010181	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1118963010182	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1118963010183	serine O-acetyltransferase; Region: cysE; TIGR01172
1118963010184	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1118963010185	trimer interface [polypeptide binding]; other site
1118963010186	active site
1118963010187	substrate binding site [chemical binding]; other site
1118963010188	CoA binding site [chemical binding]; other site
1118963010189	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1118963010190	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1118963010191	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1118963010192	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1118963010193	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1118963010194	NADP-binding site; other site
1118963010195	homotetramer interface [polypeptide binding]; other site
1118963010196	substrate binding site [chemical binding]; other site
1118963010197	homodimer interface [polypeptide binding]; other site
1118963010198	active site
1118963010199	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1118963010200	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1118963010201	NADP binding site [chemical binding]; other site
1118963010202	active site
1118963010203	putative substrate binding site [chemical binding]; other site
1118963010204	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1118963010205	CoA binding domain; Region: CoA_binding; cl17356
1118963010206	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1118963010207	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1118963010208	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
1118963010209	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1118963010210	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1118963010211	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
1118963010212	VanZ like family; Region: VanZ; cl01971
1118963010213	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1118963010214	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1118963010215	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1118963010216	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1118963010217	active site
1118963010218	catalytic triad [active]
1118963010219	oxyanion hole [active]
1118963010220	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963010221	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963010222	Helix-turn-helix domain; Region: HTH_17; pfam12728
1118963010223	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1118963010224	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1118963010225	putative di-iron ligands [ion binding]; other site
1118963010226	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1118963010227	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1118963010228	FAD binding pocket [chemical binding]; other site
1118963010229	FAD binding motif [chemical binding]; other site
1118963010230	phosphate binding motif [ion binding]; other site
1118963010231	beta-alpha-beta structure motif; other site
1118963010232	NAD binding pocket [chemical binding]; other site
1118963010233	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1118963010234	catalytic loop [active]
1118963010235	iron binding site [ion binding]; other site
1118963010236	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963010237	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963010238	S-layer homology domain; Region: SLH; pfam00395
1118963010239	Putative Ig domain; Region: He_PIG; pfam05345
1118963010240	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1118963010241	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010242	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010243	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010244	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010245	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010246	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1118963010247	Outer membrane lipoprotein LolB; Region: LolB; cl19307
1118963010248	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1118963010249	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1118963010250	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963010251	Coenzyme A binding pocket [chemical binding]; other site
1118963010252	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
1118963010253	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
1118963010254	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963010255	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963010256	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963010257	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1118963010258	hypothetical protein; Validated; Region: PRK00029
1118963010259	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1118963010260	S-layer homology domain; Region: SLH; pfam00395
1118963010261	S-layer homology domain; Region: SLH; pfam00395
1118963010262	Excalibur calcium-binding domain; Region: Excalibur; smart00894
1118963010263	S-layer homology domain; Region: SLH; pfam00395
1118963010264	S-layer homology domain; Region: SLH; pfam00395
1118963010265	S-layer homology domain; Region: SLH; pfam00395
1118963010266	S-layer homology domain; Region: SLH; pfam00395
1118963010267	S-layer homology domain; Region: SLH; pfam00395
1118963010268	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1118963010269	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
1118963010270	active site
1118963010271	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1118963010272	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1118963010273	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1118963010274	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1118963010275	PQQ-like domain; Region: PQQ_2; pfam13360
1118963010276	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1118963010277	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1118963010278	substrate binding site [chemical binding]; other site
1118963010279	oxyanion hole (OAH) forming residues; other site
1118963010280	trimer interface [polypeptide binding]; other site
1118963010281	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1118963010282	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1118963010283	FAD binding pocket [chemical binding]; other site
1118963010284	FAD binding motif [chemical binding]; other site
1118963010285	phosphate binding motif [ion binding]; other site
1118963010286	beta-alpha-beta structure motif; other site
1118963010287	NAD(p) ribose binding residues [chemical binding]; other site
1118963010288	NAD binding pocket [chemical binding]; other site
1118963010289	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1118963010290	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1118963010291	catalytic loop [active]
1118963010292	iron binding site [ion binding]; other site
1118963010293	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1118963010294	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
1118963010295	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
1118963010296	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
1118963010297	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
1118963010298	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1118963010299	active site
1118963010300	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1118963010301	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1118963010302	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
1118963010303	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1118963010304	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1118963010305	Catalytic site [active]
1118963010306	VanZ like family; Region: VanZ; cl01971
1118963010307	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1118963010308	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1118963010309	putative active site [active]
1118963010310	heme pocket [chemical binding]; other site
1118963010311	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1118963010312	dimer interface [polypeptide binding]; other site
1118963010313	phosphorylation site [posttranslational modification]
1118963010314	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963010315	ATP binding site [chemical binding]; other site
1118963010316	Mg2+ binding site [ion binding]; other site
1118963010317	G-X-G motif; other site
1118963010318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963010319	active site
1118963010320	phosphorylation site [posttranslational modification]
1118963010321	intermolecular recognition site; other site
1118963010322	dimerization interface [polypeptide binding]; other site
1118963010323	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963010324	active site
1118963010325	phosphorylation site [posttranslational modification]
1118963010326	intermolecular recognition site; other site
1118963010327	dimerization interface [polypeptide binding]; other site
1118963010328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963010329	active site
1118963010330	phosphorylation site [posttranslational modification]
1118963010331	intermolecular recognition site; other site
1118963010332	dimerization interface [polypeptide binding]; other site
1118963010333	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1118963010334	metal binding site [ion binding]; metal-binding site
1118963010335	active site
1118963010336	I-site; other site
1118963010337	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1118963010338	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1118963010339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963010340	S-adenosylmethionine binding site [chemical binding]; other site
1118963010341	SpoIIAA-like; Region: SpoIIAA-like; pfam11964
1118963010342	GAF domain; Region: GAF; pfam01590
1118963010343	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1118963010344	dimer interface [polypeptide binding]; other site
1118963010345	phosphorylation site [posttranslational modification]
1118963010346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963010347	ATP binding site [chemical binding]; other site
1118963010348	Mg2+ binding site [ion binding]; other site
1118963010349	G-X-G motif; other site
1118963010350	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1118963010351	metal binding site [ion binding]; metal-binding site
1118963010352	active site
1118963010353	I-site; other site
1118963010354	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1118963010355	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1118963010356	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1118963010357	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1118963010358	CoenzymeA binding site [chemical binding]; other site
1118963010359	subunit interaction site [polypeptide binding]; other site
1118963010360	PHB binding site; other site
1118963010361	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1118963010362	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
1118963010363	acyl-activating enzyme (AAE) consensus motif; other site
1118963010364	AMP binding site [chemical binding]; other site
1118963010365	active site
1118963010366	CoA binding site [chemical binding]; other site
1118963010367	VirC2 protein; Region: VirC2; cl06281
1118963010368	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963010369	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963010370	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
1118963010371	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
1118963010372	substrate binding site [chemical binding]; other site
1118963010373	dimer interface [polypeptide binding]; other site
1118963010374	NADP binding site [chemical binding]; other site
1118963010375	catalytic residues [active]
1118963010376	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1118963010377	active site 2 [active]
1118963010378	active site 1 [active]
1118963010379	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cl18200
1118963010380	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1118963010381	S-layer homology domain; Region: SLH; pfam00395
1118963010382	S-layer homology domain; Region: SLH; pfam00395
1118963010383	S-layer homology domain; Region: SLH; pfam00395
1118963010384	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1118963010385	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1118963010386	active site
1118963010387	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1118963010388	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963010389	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963010390	DNA binding site [nucleotide binding]
1118963010391	domain linker motif; other site
1118963010392	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1118963010393	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963010394	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1118963010395	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963010396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963010397	dimer interface [polypeptide binding]; other site
1118963010398	conserved gate region; other site
1118963010399	putative PBP binding loops; other site
1118963010400	ABC-ATPase subunit interface; other site
1118963010401	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963010402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963010403	dimer interface [polypeptide binding]; other site
1118963010404	conserved gate region; other site
1118963010405	putative PBP binding loops; other site
1118963010406	ABC-ATPase subunit interface; other site
1118963010407	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1118963010408	conserved cys residue [active]
1118963010409	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963010410	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963010411	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963010412	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
1118963010413	active site
1118963010414	catalytic triad [active]
1118963010415	oxyanion hole [active]
1118963010416	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1118963010417	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1118963010418	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1118963010419	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1118963010420	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1118963010421	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1118963010422	substrate binding site [chemical binding]; other site
1118963010423	oxyanion hole (OAH) forming residues; other site
1118963010424	trimer interface [polypeptide binding]; other site
1118963010425	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1118963010426	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1118963010427	dimer interface [polypeptide binding]; other site
1118963010428	active site
1118963010429	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1118963010430	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1118963010431	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1118963010432	hydrophobic ligand binding site; other site
1118963010433	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1118963010434	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1118963010435	iron-sulfur cluster [ion binding]; other site
1118963010436	[2Fe-2S] cluster binding site [ion binding]; other site
1118963010437	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1118963010438	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963010439	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1118963010440	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1118963010441	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
1118963010442	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1118963010443	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963010444	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963010445	Domain of unknown function (DUF4098); Region: DUF4098; cl19992
1118963010446	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1118963010447	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1118963010448	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1118963010449	ABC-ATPase subunit  interface; other site
1118963010450	dimer interface [polypeptide binding]; other site
1118963010451	putative PBP binding regions; other site
1118963010452	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1118963010453	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1118963010454	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1118963010455	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1118963010456	metal binding site [ion binding]; metal-binding site
1118963010457	CAAX protease self-immunity; Region: Abi; pfam02517
1118963010458	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1118963010459	active site
1118963010460	metal binding site [ion binding]; metal-binding site
1118963010461	Dihydroxynaphthoic acid synthase [Coenzyme metabolism]; Region: MenB; COG0447
1118963010462	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1118963010463	substrate binding site [chemical binding]; other site
1118963010464	oxyanion hole (OAH) forming residues; other site
1118963010465	trimer interface [polypeptide binding]; other site
1118963010466	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
1118963010467	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1118963010468	acyl-activating enzyme (AAE) consensus motif; other site
1118963010469	AMP binding site [chemical binding]; other site
1118963010470	active site
1118963010471	CoA binding site [chemical binding]; other site
1118963010472	1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962
1118963010473	putative active site [active]
1118963010474	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
1118963010475	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1118963010476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416
1118963010477	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1118963010478	G1 box; other site
1118963010479	GTP/Mg2+ binding site [chemical binding]; other site
1118963010480	G2 box; other site
1118963010481	Switch I region; other site
1118963010482	G3 box; other site
1118963010483	Switch II region; other site
1118963010484	G4 box; other site
1118963010485	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1118963010486	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1118963010487	G1 box; other site
1118963010488	G1 box; other site
1118963010489	GTP/Mg2+ binding site [chemical binding]; other site
1118963010490	GTP/Mg2+ binding site [chemical binding]; other site
1118963010491	G2 box; other site
1118963010492	G2 box; other site
1118963010493	Switch I region; other site
1118963010494	Switch I region; other site
1118963010495	G3 box; other site
1118963010496	G3 box; other site
1118963010497	Switch II region; other site
1118963010498	Switch II region; other site
1118963010499	G4 box; other site
1118963010500	G5 box; other site
1118963010501	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1118963010502	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963010503	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963010504	DNA binding residues [nucleotide binding]
1118963010505	dimerization interface [polypeptide binding]; other site
1118963010506	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
1118963010507	cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904
1118963010508	nucleotide binding site [chemical binding]; other site
1118963010509	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1118963010510	SBD interface [polypeptide binding]; other site
1118963010511	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1118963010512	ResB-like family; Region: ResB; pfam05140
1118963010513	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1118963010514	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1118963010515	catalytic residues [active]
1118963010516	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1118963010517	catalytic core [active]
1118963010518	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1118963010519	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1118963010520	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1118963010521	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1118963010522	CoA binding domain; Region: CoA_binding; pfam02629
1118963010523	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1118963010524	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1118963010525	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963010526	motif II; other site
1118963010527	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1118963010528	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1118963010529	putative active site [active]
1118963010530	DNA binding domain, excisionase family; Region: excise; TIGR01764
1118963010531	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1118963010532	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1118963010533	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963010534	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963010535	Methane oxygenase PmoA; Region: PmoA; pfam14100
1118963010536	H+ Antiporter protein; Region: 2A0121; TIGR00900
1118963010537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963010538	putative substrate translocation pore; other site
1118963010539	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963010540	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963010541	dimer interface [polypeptide binding]; other site
1118963010542	conserved gate region; other site
1118963010543	putative PBP binding loops; other site
1118963010544	ABC-ATPase subunit interface; other site
1118963010545	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963010546	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963010547	dimer interface [polypeptide binding]; other site
1118963010548	putative PBP binding loops; other site
1118963010549	ABC-ATPase subunit interface; other site
1118963010550	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963010551	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963010552	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1118963010553	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1118963010554	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1118963010555	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1118963010556	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963010557	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963010558	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963010559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963010560	dimer interface [polypeptide binding]; other site
1118963010561	conserved gate region; other site
1118963010562	putative PBP binding loops; other site
1118963010563	ABC-ATPase subunit interface; other site
1118963010564	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963010565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963010566	dimer interface [polypeptide binding]; other site
1118963010567	conserved gate region; other site
1118963010568	putative PBP binding loops; other site
1118963010569	ABC-ATPase subunit interface; other site
1118963010570	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1118963010571	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963010572	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963010573	Methane oxygenase PmoA; Region: PmoA; pfam14100
1118963010574	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1118963010575	active site
1118963010576	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1118963010577	dimer interface [polypeptide binding]; other site
1118963010578	NADP binding site [chemical binding]; other site
1118963010579	catalytic residues [active]
1118963010580	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1118963010581	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1118963010582	active site pocket [active]
1118963010583	5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620
1118963010584	catalytic residue [active]
1118963010585	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963010586	extended (e) SDRs; Region: SDR_e; cd08946
1118963010587	NAD(P) binding site [chemical binding]; other site
1118963010588	active site
1118963010589	substrate binding site [chemical binding]; other site
1118963010590	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963010591	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963010592	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963010593	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963010594	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963010595	DNA binding site [nucleotide binding]
1118963010596	domain linker motif; other site
1118963010597	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963010598	dimerization interface [polypeptide binding]; other site
1118963010599	ligand binding site [chemical binding]; other site
1118963010600	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1118963010601	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963010602	DNA-binding site [nucleotide binding]; DNA binding site
1118963010603	FCD domain; Region: FCD; pfam07729
1118963010604	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1118963010605	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1118963010606	active site
1118963010607	substrate binding site [chemical binding]; other site
1118963010608	FMN binding site [chemical binding]; other site
1118963010609	putative catalytic residues [active]
1118963010610	glutamate dehydrogenase; Provisional; Region: PRK09414
1118963010611	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
1118963010612	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1118963010613	NAD(P) binding site [chemical binding]; other site
1118963010614	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963010615	dimerization interface [polypeptide binding]; other site
1118963010616	putative DNA binding site [nucleotide binding]; other site
1118963010617	putative Zn2+ binding site [ion binding]; other site
1118963010618	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1118963010619	active site
1118963010620	Zn binding site [ion binding]; other site
1118963010621	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1118963010622	Cation transport protein; Region: TrkH; cl17365
1118963010623	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1118963010624	TrkA-N domain; Region: TrkA_N; pfam02254
1118963010625	TrkA-C domain; Region: TrkA_C; pfam02080
1118963010626	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1118963010627	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1118963010628	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
1118963010629	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963010630	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963010631	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1118963010632	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483
1118963010633	SseB protein N-terminal domain; Region: SseB; pfam07179
1118963010634	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1118963010635	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1118963010636	active site
1118963010637	interdomain interaction site; other site
1118963010638	putative metal-binding site [ion binding]; other site
1118963010639	nucleotide binding site [chemical binding]; other site
1118963010640	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1118963010641	domain I; other site
1118963010642	DNA binding groove [nucleotide binding]
1118963010643	phosphate binding site [ion binding]; other site
1118963010644	domain II; other site
1118963010645	domain III; other site
1118963010646	nucleotide binding site [chemical binding]; other site
1118963010647	catalytic site [active]
1118963010648	domain IV; other site
1118963010649	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1118963010650	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1118963010651	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1118963010652	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963010653	dimerization interface [polypeptide binding]; other site
1118963010654	putative DNA binding site [nucleotide binding]; other site
1118963010655	putative Zn2+ binding site [ion binding]; other site
1118963010656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963010657	S-adenosylmethionine binding site [chemical binding]; other site
1118963010658	Src homology 2 (SH2) domain; Region: SH2; cl15255
1118963010659	phosphotyrosine binding pocket [polypeptide binding]; other site
1118963010660	hydrophobic binding pocket [polypeptide binding]; other site
1118963010661	hypothetical protein; Validated; Region: PRK01415
1118963010662	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1118963010663	active site residue [active]
1118963010664	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963010665	Coenzyme A binding pocket [chemical binding]; other site
1118963010666	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
1118963010667	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963010668	ATP binding site [chemical binding]; other site
1118963010669	putative Mg++ binding site [ion binding]; other site
1118963010670	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963010671	nucleotide binding region [chemical binding]; other site
1118963010672	ATP-binding site [chemical binding]; other site
1118963010673	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1118963010674	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
1118963010675	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
1118963010676	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1118963010677	Type II secretion system (T2SS), protein F; Region: T2SF; cl19503
1118963010678	helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819
1118963010679	Walker A motif; other site
1118963010680	ATP binding site [chemical binding]; other site
1118963010681	Walker B motif; other site
1118963010682	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
1118963010683	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
1118963010684	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444
1118963010685	active site
1118963010686	DNA binding site [nucleotide binding]
1118963010687	catalytic site [active]
1118963010688	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
1118963010689	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1118963010690	putative active site [active]
1118963010691	putative CoA binding site [chemical binding]; other site
1118963010692	nudix motif; other site
1118963010693	metal binding site [ion binding]; metal-binding site
1118963010694	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1118963010695	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1118963010696	minor groove reading motif; other site
1118963010697	helix-hairpin-helix signature motif; other site
1118963010698	substrate binding pocket [chemical binding]; other site
1118963010699	active site
1118963010700	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1118963010701	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
1118963010702	acetyl-CoA synthetase; Provisional; Region: PRK00174
1118963010703	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1118963010704	active site
1118963010705	CoA binding site [chemical binding]; other site
1118963010706	acyl-activating enzyme (AAE) consensus motif; other site
1118963010707	AMP binding site [chemical binding]; other site
1118963010708	acetate binding site [chemical binding]; other site
1118963010709	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1118963010710	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1118963010711	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1118963010712	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1118963010713	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1118963010714	Walker A/P-loop; other site
1118963010715	ATP binding site [chemical binding]; other site
1118963010716	Q-loop/lid; other site
1118963010717	ABC transporter signature motif; other site
1118963010718	Walker B; other site
1118963010719	D-loop; other site
1118963010720	H-loop/switch region; other site
1118963010721	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963010722	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963010723	DNA binding site [nucleotide binding]
1118963010724	domain linker motif; other site
1118963010725	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963010726	dimerization interface [polypeptide binding]; other site
1118963010727	ligand binding site [chemical binding]; other site
1118963010728	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963010729	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963010730	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963010731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963010732	dimer interface [polypeptide binding]; other site
1118963010733	conserved gate region; other site
1118963010734	putative PBP binding loops; other site
1118963010735	ABC-ATPase subunit interface; other site
1118963010736	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963010737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963010738	dimer interface [polypeptide binding]; other site
1118963010739	conserved gate region; other site
1118963010740	putative PBP binding loops; other site
1118963010741	ABC-ATPase subunit interface; other site
1118963010742	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963010743	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963010744	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1118963010745	Melibiase; Region: Melibiase; pfam02065
1118963010746	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1118963010747	trimer interface [polypeptide binding]; other site
1118963010748	active site
1118963010749	dimer interface [polypeptide binding]; other site
1118963010750	Colicin V production protein; Region: Colicin_V; pfam02674
1118963010751	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1118963010752	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1118963010753	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1118963010754	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1118963010755	ligand binding site [chemical binding]; other site
1118963010756	flexible hinge region; other site
1118963010757	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1118963010758	putative switch regulator; other site
1118963010759	non-specific DNA interactions [nucleotide binding]; other site
1118963010760	DNA binding site [nucleotide binding]
1118963010761	sequence specific DNA binding site [nucleotide binding]; other site
1118963010762	putative cAMP binding site [chemical binding]; other site
1118963010763	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1118963010764	nudix motif; other site
1118963010765	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1118963010766	homotrimer interaction site [polypeptide binding]; other site
1118963010767	putative active site [active]
1118963010768	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1118963010769	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1118963010770	Transglycosylase; Region: Transgly; pfam00912
1118963010771	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1118963010772	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1118963010773	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1118963010774	putative active site [active]
1118963010775	putative metal binding site [ion binding]; other site
1118963010776	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1118963010777	MMPL family; Region: MMPL; cl14618
1118963010778	MMPL family; Region: MMPL; cl14618
1118963010779	hypothetical protein; Validated; Region: PRK06840
1118963010780	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1118963010781	active site
1118963010782	hypothetical protein; Provisional; Region: PRK06184
1118963010783	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963010784	A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756
1118963010785	A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756
1118963010786	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963010787	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963010788	active site
1118963010789	catalytic tetrad [active]
1118963010790	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1118963010791	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1118963010792	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963010793	Walker A/P-loop; other site
1118963010794	ATP binding site [chemical binding]; other site
1118963010795	Q-loop/lid; other site
1118963010796	ABC transporter signature motif; other site
1118963010797	Walker B; other site
1118963010798	D-loop; other site
1118963010799	H-loop/switch region; other site
1118963010800	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1118963010801	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1118963010802	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963010803	Walker A/P-loop; other site
1118963010804	ATP binding site [chemical binding]; other site
1118963010805	Q-loop/lid; other site
1118963010806	ABC transporter signature motif; other site
1118963010807	Walker B; other site
1118963010808	D-loop; other site
1118963010809	H-loop/switch region; other site
1118963010810	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1118963010811	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963010812	non-specific DNA binding site [nucleotide binding]; other site
1118963010813	salt bridge; other site
1118963010814	sequence-specific DNA binding site [nucleotide binding]; other site
1118963010815	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1118963010816	ATP binding site [chemical binding]; other site
1118963010817	active site
1118963010818	phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959
1118963010819	substrate binding site [chemical binding]; other site
1118963010820	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1118963010821	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1118963010822	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1118963010823	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1118963010824	L-asparaginase II; Region: Asparaginase_II; pfam06089
1118963010825	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1118963010826	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1118963010827	classical (c) SDRs; Region: SDR_c; cd05233
1118963010828	NAD(P) binding site [chemical binding]; other site
1118963010829	active site
1118963010830	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1118963010831	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
1118963010832	Na binding site [ion binding]; other site
1118963010833	putative substrate binding site [chemical binding]; other site
1118963010834	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1118963010835	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1118963010836	dimer interface [polypeptide binding]; other site
1118963010837	TPP-binding site [chemical binding]; other site
1118963010838	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
1118963010839	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1118963010840	Ligand binding site; other site
1118963010841	metal-binding site
1118963010842	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1118963010843	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963010844	Coenzyme A binding pocket [chemical binding]; other site
1118963010845	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
1118963010846	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1118963010847	catalytic loop [active]
1118963010848	iron binding site [ion binding]; other site
1118963010849	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1118963010850	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
1118963010851	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1118963010852	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1118963010853	FAD binding domain; Region: FAD_binding_4; cl19922
1118963010854	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1118963010855	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1118963010856	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1118963010857	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1118963010858	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1118963010859	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1118963010860	nucleoside/Zn binding site; other site
1118963010861	dimer interface [polypeptide binding]; other site
1118963010862	catalytic motif [active]
1118963010863	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
1118963010864	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1118963010865	active site
1118963010866	putative substrate binding pocket [chemical binding]; other site
1118963010867	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1118963010868	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1118963010869	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1118963010870	putative active site [active]
1118963010871	urate oxidase; Region: urate_oxi; TIGR03383
1118963010872	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1118963010873	active site
1118963010874	Sulfate transporter family; Region: Sulfate_transp; cl19250
1118963010875	xanthine permease; Region: pbuX; TIGR03173
1118963010876	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
1118963010877	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963010878	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963010879	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963010880	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1118963010881	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1118963010882	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1118963010883	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1118963010884	putative NAD(P) binding site [chemical binding]; other site
1118963010885	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
1118963010886	active site
1118963010887	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1118963010888	hypothetical protein; Provisional; Region: PRK11171
1118963010889	Cupin domain; Region: Cupin_2; pfam07883
1118963010890	Cupin domain; Region: Cupin_2; pfam07883
1118963010891	YjbR; Region: YjbR; pfam04237
1118963010892	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1118963010893	benzoate transport; Region: 2A0115; TIGR00895
1118963010894	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963010895	putative substrate translocation pore; other site
1118963010896	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1118963010897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963010898	ATP binding site [chemical binding]; other site
1118963010899	Mg2+ binding site [ion binding]; other site
1118963010900	G-X-G motif; other site
1118963010901	Transglycosylase; Region: Transgly; pfam00912
1118963010902	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1118963010903	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1118963010904	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1118963010905	catalytic triad [active]
1118963010906	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1118963010907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963010908	putative substrate translocation pore; other site
1118963010909	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1118963010910	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
1118963010911	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1118963010912	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1118963010913	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1118963010914	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
1118963010915	active site clefts [active]
1118963010916	zinc binding site [ion binding]; other site
1118963010917	dimer interface [polypeptide binding]; other site
1118963010918	FG-GAP repeat; Region: FG-GAP; pfam01839
1118963010919	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1118963010920	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1118963010921	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1118963010922	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1118963010923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963010924	S-adenosylmethionine binding site [chemical binding]; other site
1118963010925	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1118963010926	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1118963010927	active site
1118963010928	adenylate kinase; Reviewed; Region: adk; PRK00279
1118963010929	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1118963010930	AMP-binding site [chemical binding]; other site
1118963010931	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1118963010932	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1118963010933	putative hydrophobic ligand binding site [chemical binding]; other site
1118963010934	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963010935	dimerization interface [polypeptide binding]; other site
1118963010936	putative DNA binding site [nucleotide binding]; other site
1118963010937	putative Zn2+ binding site [ion binding]; other site
1118963010938	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1118963010939	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1118963010940	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1118963010941	putative active site [active]
1118963010942	benzoate transport; Region: 2A0115; TIGR00895
1118963010943	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963010944	putative substrate translocation pore; other site
1118963010945	GAF domain; Region: GAF; cl17456
1118963010946	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1118963010947	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963010948	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1118963010949	active site
1118963010950	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
1118963010951	putative hydrophobic ligand binding site [chemical binding]; other site
1118963010952	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1118963010953	metal binding site [ion binding]; metal-binding site
1118963010954	active site
1118963010955	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1118963010956	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1118963010957	DXD motif; other site
1118963010958	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1118963010959	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
1118963010960	active site
1118963010961	catalytic residues [active]
1118963010962	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1118963010963	nudix motif; other site
1118963010964	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1118963010965	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963010966	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963010967	MOSC domain; Region: MOSC; pfam03473
1118963010968	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1118963010969	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1118963010970	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1118963010971	Walker A/P-loop; other site
1118963010972	ATP binding site [chemical binding]; other site
1118963010973	Q-loop/lid; other site
1118963010974	ABC transporter signature motif; other site
1118963010975	Walker B; other site
1118963010976	D-loop; other site
1118963010977	H-loop/switch region; other site
1118963010978	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1118963010979	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1118963010980	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963010981	Walker A/P-loop; other site
1118963010982	ATP binding site [chemical binding]; other site
1118963010983	Q-loop/lid; other site
1118963010984	ABC transporter signature motif; other site
1118963010985	Walker B; other site
1118963010986	D-loop; other site
1118963010987	H-loop/switch region; other site
1118963010988	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1118963010989	Predicted transcriptional regulators [Transcription]; Region: COG1733
1118963010990	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963010991	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963010992	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
1118963010993	putative active site; other site
1118963010994	putative metal binding residues [ion binding]; other site
1118963010995	signature motif; other site
1118963010996	putative triphosphate binding site [ion binding]; other site
1118963010997	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
1118963010998	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
1118963010999	putative hydrophobic ligand binding site [chemical binding]; other site
1118963011000	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963011001	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963011002	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963011003	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1118963011004	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1118963011005	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1118963011006	substrate binding site [chemical binding]; other site
1118963011007	oxyanion hole (OAH) forming residues; other site
1118963011008	trimer interface [polypeptide binding]; other site
1118963011009	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1118963011010	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1118963011011	active site
1118963011012	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1118963011013	nudix motif; other site
1118963011014	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1118963011015	SPFH domain / Band 7 family; Region: Band_7; pfam01145
1118963011016	NADH kinase; Region: PLN02929
1118963011017	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1118963011018	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1118963011019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963011020	Walker A/P-loop; other site
1118963011021	ATP binding site [chemical binding]; other site
1118963011022	Q-loop/lid; other site
1118963011023	ABC transporter signature motif; other site
1118963011024	Walker B; other site
1118963011025	D-loop; other site
1118963011026	H-loop/switch region; other site
1118963011027	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1118963011028	Peptidase family M50; Region: Peptidase_M50; pfam02163
1118963011029	active site
1118963011030	putative substrate binding region [chemical binding]; other site
1118963011031	YcaO-like family; Region: YcaO; pfam02624
1118963011032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963011033	S-adenosylmethionine binding site [chemical binding]; other site
1118963011034	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1118963011035	active site
1118963011036	NAD binding site [chemical binding]; other site
1118963011037	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1118963011038	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
1118963011039	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963011040	catalytic residue [active]
1118963011041	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1118963011042	conserved cys residue [active]
1118963011043	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963011044	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963011045	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963011046	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963011047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963011048	dimer interface [polypeptide binding]; other site
1118963011049	conserved gate region; other site
1118963011050	putative PBP binding loops; other site
1118963011051	ABC-ATPase subunit interface; other site
1118963011052	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1118963011053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963011054	dimer interface [polypeptide binding]; other site
1118963011055	conserved gate region; other site
1118963011056	putative PBP binding loops; other site
1118963011057	ABC-ATPase subunit interface; other site
1118963011058	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963011059	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963011060	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963011061	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963011062	DNA binding site [nucleotide binding]
1118963011063	domain linker motif; other site
1118963011064	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1118963011065	ligand binding site [chemical binding]; other site
1118963011066	dimerization interface [polypeptide binding]; other site
1118963011067	sporadically distributed protein, TIGR04141 family; Region: TIGR04141
1118963011068	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1118963011069	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963011070	non-specific DNA binding site [nucleotide binding]; other site
1118963011071	salt bridge; other site
1118963011072	sequence-specific DNA binding site [nucleotide binding]; other site
1118963011073	Domain of unknown function (DUF955); Region: DUF955; cl01076
1118963011074	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1118963011075	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1118963011076	EcsC protein family; Region: EcsC; pfam12787
1118963011077	Pleckstrin homology-like domain; Region: PH-like; cl17171
1118963011078	TM2 domain; Region: TM2; pfam05154
1118963011079	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1118963011080	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1118963011081	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1118963011082	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1118963011083	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
1118963011084	glyoxylate carboligase; Provisional; Region: PRK11269
1118963011085	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1118963011086	PYR/PP interface [polypeptide binding]; other site
1118963011087	dimer interface [polypeptide binding]; other site
1118963011088	TPP binding site [chemical binding]; other site
1118963011089	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1118963011090	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1118963011091	TPP-binding site [chemical binding]; other site
1118963011092	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1118963011093	allantoinase; Region: allantoinase; TIGR03178
1118963011094	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963011095	active site
1118963011096	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1118963011097	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1118963011098	DNA binding site [nucleotide binding]
1118963011099	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1118963011100	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1118963011101	catalytic triad [active]
1118963011102	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1118963011103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963011104	active site
1118963011105	phosphorylation site [posttranslational modification]
1118963011106	intermolecular recognition site; other site
1118963011107	dimerization interface [polypeptide binding]; other site
1118963011108	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1118963011109	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1118963011110	DXD motif; other site
1118963011111	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1118963011112	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1118963011113	anti sigma factor interaction site; other site
1118963011114	regulatory phosphorylation site [posttranslational modification]; other site
1118963011115	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1118963011116	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1118963011117	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963011118	catalytic residue [active]
1118963011119	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1118963011120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963011121	putative substrate translocation pore; other site
1118963011122	Predicted transcriptional regulators [Transcription]; Region: COG1733
1118963011123	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1118963011124	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1118963011125	active site
1118963011126	OHCU decarboxylase; Region: UraD_2; TIGR03180
1118963011127	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1118963011128	active site
1118963011129	homotetramer interface [polypeptide binding]; other site
1118963011130	amidophosphoribosyltransferase; Provisional; Region: PRK07847
1118963011131	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1118963011132	active site
1118963011133	tetramer interface [polypeptide binding]; other site
1118963011134	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1118963011135	active site
1118963011136	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1118963011137	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1118963011138	dimerization interface [polypeptide binding]; other site
1118963011139	putative ATP binding site [chemical binding]; other site
1118963011140	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1118963011141	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1118963011142	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1118963011143	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1118963011144	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
1118963011145	YppG-like protein; Region: YppG; pfam14179
1118963011146	Septum formation; Region: Septum_form; pfam13845
1118963011147	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1118963011148	Clp amino terminal domain; Region: Clp_N; pfam02861
1118963011149	Clp amino terminal domain; Region: Clp_N; pfam02861
1118963011150	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963011151	Walker A motif; other site
1118963011152	ATP binding site [chemical binding]; other site
1118963011153	Walker B motif; other site
1118963011154	arginine finger; other site
1118963011155	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963011156	Walker A motif; other site
1118963011157	ATP binding site [chemical binding]; other site
1118963011158	Walker B motif; other site
1118963011159	arginine finger; other site
1118963011160	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1118963011161	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1118963011162	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
1118963011163	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1118963011164	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963011165	Walker A/P-loop; other site
1118963011166	ATP binding site [chemical binding]; other site
1118963011167	Q-loop/lid; other site
1118963011168	ABC transporter signature motif; other site
1118963011169	Walker B; other site
1118963011170	D-loop; other site
1118963011171	H-loop/switch region; other site
1118963011172	TOBE domain; Region: TOBE; pfam03459
1118963011173	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1118963011174	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963011175	dimer interface [polypeptide binding]; other site
1118963011176	conserved gate region; other site
1118963011177	putative PBP binding loops; other site
1118963011178	ABC-ATPase subunit interface; other site
1118963011179	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1118963011180	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1118963011181	DNA binding residues [nucleotide binding]
1118963011182	TOBE domain; Region: TOBE; cl01440
1118963011183	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1118963011184	FAD binding domain; Region: FAD_binding_4; pfam01565
1118963011185	Berberine and berberine like; Region: BBE; pfam08031
1118963011186	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
1118963011187	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1118963011188	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
1118963011189	catalytic site [active]
1118963011190	BNR repeat-like domain; Region: BNR_2; pfam13088
1118963011191	Asp-box motif; other site
1118963011192	hypothetical protein; Provisional; Region: PRK11770
1118963011193	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1118963011194	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1118963011195	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1118963011196	putative hydrophobic ligand binding site [chemical binding]; other site
1118963011197	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1118963011198	active site
1118963011199	HutD; Region: HutD; pfam05962
1118963011200	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1118963011201	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1118963011202	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963011203	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963011204	active site
1118963011205	catalytic tetrad [active]
1118963011206	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1118963011207	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1118963011208	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1118963011209	ATP binding site [chemical binding]; other site
1118963011210	putative Mg++ binding site [ion binding]; other site
1118963011211	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963011212	nucleotide binding region [chemical binding]; other site
1118963011213	ATP-binding site [chemical binding]; other site
1118963011214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963011215	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963011216	putative substrate translocation pore; other site
1118963011217	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
1118963011218	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
1118963011219	DNA binding residues [nucleotide binding]
1118963011220	dimer interface [polypeptide binding]; other site
1118963011221	[2Fe-2S] cluster binding site [ion binding]; other site
1118963011222	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963011223	S-adenosylmethionine binding site [chemical binding]; other site
1118963011224	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963011225	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1118963011226	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963011227	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963011228	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1118963011229	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1118963011230	metal binding site [ion binding]; metal-binding site
1118963011231	dimer interface [polypeptide binding]; other site
1118963011232	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963011233	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963011234	putative substrate translocation pore; other site
1118963011235	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1118963011236	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963011237	putative substrate translocation pore; other site
1118963011238	quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907
1118963011239	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1118963011240	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1118963011241	hydrophobic ligand binding site; other site
1118963011242	Putative zinc-finger; Region: zf-HC2; pfam13490
1118963011243	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
1118963011244	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963011245	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1118963011246	DNA binding residues [nucleotide binding]
1118963011247	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1118963011248	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1118963011249	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1118963011250	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1118963011251	putative active site [active]
1118963011252	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1118963011253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963011254	Walker A/P-loop; other site
1118963011255	ATP binding site [chemical binding]; other site
1118963011256	Q-loop/lid; other site
1118963011257	ABC transporter signature motif; other site
1118963011258	Walker B; other site
1118963011259	D-loop; other site
1118963011260	H-loop/switch region; other site
1118963011261	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1118963011262	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1118963011263	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
1118963011264	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1118963011265	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963011266	ATP binding site [chemical binding]; other site
1118963011267	putative Mg++ binding site [ion binding]; other site
1118963011268	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963011269	nucleotide binding region [chemical binding]; other site
1118963011270	ATP-binding site [chemical binding]; other site
1118963011271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963011272	putative substrate translocation pore; other site
1118963011273	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963011274	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1118963011275	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963011276	DNA-binding site [nucleotide binding]; DNA binding site
1118963011277	FCD domain; Region: FCD; pfam07729
1118963011278	amidase; Validated; Region: PRK06565
1118963011279	Amidinotransferase; Region: Amidinotransf; cl19186
1118963011280	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963011281	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963011282	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1118963011283	glycogen branching enzyme; Provisional; Region: PRK14705
1118963011284	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
1118963011285	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963011286	dimerization interface [polypeptide binding]; other site
1118963011287	putative DNA binding site [nucleotide binding]; other site
1118963011288	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963011289	putative Zn2+ binding site [ion binding]; other site
1118963011290	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963011291	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963011292	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963011293	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963011294	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1118963011295	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1118963011296	NAD(P) binding site [chemical binding]; other site
1118963011297	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1118963011298	TPP-binding site [chemical binding]; other site
1118963011299	dimer interface [polypeptide binding]; other site
1118963011300	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1118963011301	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1118963011302	PYR/PP interface [polypeptide binding]; other site
1118963011303	dimer interface [polypeptide binding]; other site
1118963011304	TPP binding site [chemical binding]; other site
1118963011305	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1118963011306	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1118963011307	ATP binding site [chemical binding]; other site
1118963011308	substrate binding site [chemical binding]; other site
1118963011309	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963011310	classical (c) SDRs; Region: SDR_c; cd05233
1118963011311	NAD(P) binding site [chemical binding]; other site
1118963011312	active site
1118963011313	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1118963011314	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1118963011315	NAD(P) binding site [chemical binding]; other site
1118963011316	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963011317	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963011318	putative substrate translocation pore; other site
1118963011319	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1118963011320	classical (c) SDRs; Region: SDR_c; cd05233
1118963011321	NAD(P) binding site [chemical binding]; other site
1118963011322	active site
1118963011323	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
1118963011324	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1118963011325	DNA binding residues [nucleotide binding]
1118963011326	putative dimer interface [polypeptide binding]; other site
1118963011327	chaperone protein DnaJ; Provisional; Region: PRK14295
1118963011328	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1118963011329	HSP70 interaction site [polypeptide binding]; other site
1118963011330	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1118963011331	substrate binding site [polypeptide binding]; other site
1118963011332	dimer interface [polypeptide binding]; other site
1118963011333	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1118963011334	dimer interface [polypeptide binding]; other site
1118963011335	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1118963011336	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1118963011337	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963011338	nucleotide binding site [chemical binding]; other site
1118963011339	Protein of unknown function (DUF817); Region: DUF817; pfam05675
1118963011340	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
1118963011341	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963011342	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963011343	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963011344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963011345	NAD(P) binding site [chemical binding]; other site
1118963011346	active site
1118963011347	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1118963011348	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1118963011349	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1118963011350	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963011351	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963011352	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963011353	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
1118963011354	putative ligand binding site [chemical binding]; other site
1118963011355	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1118963011356	putative NAD binding site [chemical binding]; other site
1118963011357	catalytic site [active]
1118963011358	Sulfatase; Region: Sulfatase; pfam00884
1118963011359	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1118963011360	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963011361	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1118963011362	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1118963011363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963011364	dimer interface [polypeptide binding]; other site
1118963011365	conserved gate region; other site
1118963011366	putative PBP binding loops; other site
1118963011367	ABC-ATPase subunit interface; other site
1118963011368	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963011369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963011370	dimer interface [polypeptide binding]; other site
1118963011371	conserved gate region; other site
1118963011372	putative PBP binding loops; other site
1118963011373	ABC-ATPase subunit interface; other site
1118963011374	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963011375	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
1118963011376	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
1118963011377	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1118963011378	active site
1118963011379	trimer interface [polypeptide binding]; other site
1118963011380	allosteric site; other site
1118963011381	active site lid [active]
1118963011382	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1118963011383	CAAX protease self-immunity; Region: Abi; pfam02517
1118963011384	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1118963011385	Protein of unknown function (DUF1016); Region: DUF1016; cl19557
1118963011386	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1118963011387	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1118963011388	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963011389	dimerization interface [polypeptide binding]; other site
1118963011390	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1118963011391	ligand binding site [chemical binding]; other site
1118963011392	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1118963011393	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1118963011394	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963011395	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963011396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963011397	dimer interface [polypeptide binding]; other site
1118963011398	conserved gate region; other site
1118963011399	putative PBP binding loops; other site
1118963011400	ABC-ATPase subunit interface; other site
1118963011401	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963011402	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963011403	dimer interface [polypeptide binding]; other site
1118963011404	conserved gate region; other site
1118963011405	putative PBP binding loops; other site
1118963011406	ABC-ATPase subunit interface; other site
1118963011407	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
1118963011408	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1118963011409	putative ligand binding site [chemical binding]; other site
1118963011410	putative NAD binding site [chemical binding]; other site
1118963011411	catalytic site [active]
1118963011412	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1118963011413	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1118963011414	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963011415	motif II; other site
1118963011416	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1118963011417	PhoD-like phosphatase; Region: PhoD; pfam09423
1118963011418	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1118963011419	putative active site [active]
1118963011420	putative metal binding site [ion binding]; other site
1118963011421	aminotransferase AlaT; Validated; Region: PRK09265
1118963011422	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963011423	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963011424	homodimer interface [polypeptide binding]; other site
1118963011425	catalytic residue [active]
1118963011426	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1118963011427	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
1118963011428	putative NAD(P) binding site [chemical binding]; other site
1118963011429	catalytic Zn binding site [ion binding]; other site
1118963011430	structural Zn binding site [ion binding]; other site
1118963011431	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1118963011432	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1118963011433	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1118963011434	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963011435	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1118963011436	DNA binding residues [nucleotide binding]
1118963011437	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1118963011438	tyramine oxidase; Provisional; Region: tynA; PRK11504
1118963011439	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
1118963011440	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
1118963011441	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963011442	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1118963011443	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1118963011444	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
1118963011445	NAD(P) binding site [chemical binding]; other site
1118963011446	catalytic residues [active]
1118963011447	prephenate dehydratase; Provisional; Region: PRK11899
1118963011448	Prephenate dehydratase; Region: PDT; pfam00800
1118963011449	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1118963011450	putative L-Phe binding site [chemical binding]; other site
1118963011451	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1118963011452	active site
1118963011453	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1118963011454	active site
1118963011455	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
1118963011456	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1118963011457	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1118963011458	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963011459	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963011460	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1118963011461	active site
1118963011462	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963011463	putative DNA binding site [nucleotide binding]; other site
1118963011464	dimerization interface [polypeptide binding]; other site
1118963011465	putative Zn2+ binding site [ion binding]; other site
1118963011466	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1118963011467	active site
1118963011468	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1118963011469	amphipathic channel; other site
1118963011470	Asn-Pro-Ala signature motifs; other site
1118963011471	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963011472	dimerization interface [polypeptide binding]; other site
1118963011473	putative DNA binding site [nucleotide binding]; other site
1118963011474	putative Zn2+ binding site [ion binding]; other site
1118963011475	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1118963011476	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963011477	Coenzyme A binding pocket [chemical binding]; other site
1118963011478	Transport protein; Region: actII; TIGR00833
1118963011479	MMPL family; Region: MMPL; pfam03176
1118963011480	MMPL family; Region: MMPL; cl14618
1118963011481	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963011482	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963011483	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1118963011484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963011485	S-adenosylmethionine binding site [chemical binding]; other site
1118963011486	YCII-related domain; Region: YCII; cl00999
1118963011487	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963011488	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1118963011489	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1118963011490	DNA binding residues [nucleotide binding]
1118963011491	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963011492	active site
1118963011493	catalytic tetrad [active]
1118963011494	DNA polymerase IV; Validated; Region: PRK03352
1118963011495	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1118963011496	active site
1118963011497	DNA binding site [nucleotide binding]
1118963011498	LysE type translocator; Region: LysE; cl00565
1118963011499	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963011500	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963011501	DNA binding site [nucleotide binding]
1118963011502	domain linker motif; other site
1118963011503	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963011504	dimerization interface [polypeptide binding]; other site
1118963011505	ligand binding site [chemical binding]; other site
1118963011506	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1118963011507	active site
1118963011508	tetramer interface [polypeptide binding]; other site
1118963011509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963011510	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963011511	putative substrate translocation pore; other site
1118963011512	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1118963011513	substrate binding site [chemical binding]; other site
1118963011514	dimer interface [polypeptide binding]; other site
1118963011515	ATP binding site [chemical binding]; other site
1118963011516	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963011517	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963011518	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1118963011519	active site
1118963011520	hypothetical protein; Provisional; Region: PRK06547
1118963011521	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1118963011522	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1118963011523	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1118963011524	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1118963011525	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1118963011526	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1118963011527	putative active site [active]
1118963011528	catalytic site [active]
1118963011529	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
1118963011530	putative active site [active]
1118963011531	catalytic site [active]
1118963011532	4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07849
1118963011533	homodimer interface [polypeptide binding]; other site
1118963011534	substrate-cofactor binding pocket; other site
1118963011535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963011536	catalytic residue [active]
1118963011537	S-methylmethionine transporter; Provisional; Region: PRK11387
1118963011538	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963011539	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1118963011540	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1118963011541	cysteine synthase; Region: PLN02565
1118963011542	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1118963011543	dimer interface [polypeptide binding]; other site
1118963011544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963011545	catalytic residue [active]
1118963011546	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
1118963011547	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1118963011548	active sites [active]
1118963011549	tetramer interface [polypeptide binding]; other site
1118963011550	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
1118963011551	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1118963011552	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1118963011553	Sulfate transporter family; Region: Sulfate_transp; cl19250
1118963011554	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1118963011555	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
1118963011556	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1118963011557	active site residue [active]
1118963011558	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1118963011559	homodimer interface [polypeptide binding]; other site
1118963011560	substrate-cofactor binding pocket; other site
1118963011561	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963011562	catalytic residue [active]
1118963011563	carboxylate-amine ligase; Provisional; Region: PRK13517
1118963011564	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963011565	non-specific DNA binding site [nucleotide binding]; other site
1118963011566	salt bridge; other site
1118963011567	sequence-specific DNA binding site [nucleotide binding]; other site
1118963011568	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
1118963011569	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
1118963011570	putative active site [active]
1118963011571	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1118963011572	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1118963011573	FAD binding pocket [chemical binding]; other site
1118963011574	FAD binding motif [chemical binding]; other site
1118963011575	phosphate binding motif [ion binding]; other site
1118963011576	NAD binding pocket [chemical binding]; other site
1118963011577	Penicillin amidase; Region: Penicil_amidase; pfam01804
1118963011578	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1118963011579	active site
1118963011580	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1118963011581	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1118963011582	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1118963011583	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1118963011584	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1118963011585	Walker A/P-loop; other site
1118963011586	ATP binding site [chemical binding]; other site
1118963011587	Q-loop/lid; other site
1118963011588	ABC transporter signature motif; other site
1118963011589	Walker B; other site
1118963011590	D-loop; other site
1118963011591	H-loop/switch region; other site
1118963011592	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1118963011593	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1118963011594	Walker A/P-loop; other site
1118963011595	ATP binding site [chemical binding]; other site
1118963011596	Q-loop/lid; other site
1118963011597	ABC transporter signature motif; other site
1118963011598	Walker B; other site
1118963011599	D-loop; other site
1118963011600	H-loop/switch region; other site
1118963011601	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
1118963011602	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1118963011603	nudix motif; other site
1118963011604	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1118963011605	nudix motif; other site
1118963011606	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
1118963011607	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
1118963011608	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1118963011609	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
1118963011610	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1118963011611	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
1118963011612	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
1118963011613	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1118963011614	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1118963011615	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1118963011616	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1118963011617	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1118963011618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963011619	putative substrate translocation pore; other site
1118963011620	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1118963011621	TrkA-C domain; Region: TrkA_C; pfam02080
1118963011622	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1118963011623	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1118963011624	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1118963011625	putative active site [active]
1118963011626	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1118963011627	trimer interface [polypeptide binding]; other site
1118963011628	active site
1118963011629	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1118963011630	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1118963011631	hydrophobic ligand binding site; other site
1118963011632	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1118963011633	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1118963011634	SnoaL-like domain; Region: SnoaL_2; pfam12680
1118963011635	N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181
1118963011636	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1118963011637	putative active site [active]
1118963011638	putative ligand binding site [chemical binding]; other site
1118963011639	putative NAD(P) binding site [chemical binding]; other site
1118963011640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963011641	H+ Antiporter protein; Region: 2A0121; TIGR00900
1118963011642	putative substrate translocation pore; other site
1118963011643	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963011644	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963011645	dimerization interface [polypeptide binding]; other site
1118963011646	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1118963011647	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963011648	Coenzyme A binding pocket [chemical binding]; other site
1118963011649	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963011650	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963011651	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1118963011652	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963011653	lac repressor; Reviewed; Region: lacI; PRK09526
1118963011654	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963011655	DNA binding site [nucleotide binding]
1118963011656	domain linker motif; other site
1118963011657	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963011658	dimerization interface [polypeptide binding]; other site
1118963011659	ligand binding site [chemical binding]; other site
1118963011660	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1118963011661	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963011662	Protein of unknown function (DUF993); Region: DUF993; pfam06187
1118963011663	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963011664	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963011665	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094
1118963011666	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1118963011667	Transcriptional regulator; Region: Rrf2; cl17282
1118963011668	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963011669	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963011670	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963011671	xylose isomerase; Provisional; Region: PRK12677
1118963011672	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963011673	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963011674	D-xylulose kinase; Region: XylB; TIGR01312
1118963011675	nucleotide binding site [chemical binding]; other site
1118963011676	lac repressor; Reviewed; Region: lacI; PRK09526
1118963011677	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963011678	DNA binding site [nucleotide binding]
1118963011679	domain linker motif; other site
1118963011680	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
1118963011681	ligand binding site [chemical binding]; other site
1118963011682	dimerization interface (open form) [polypeptide binding]; other site
1118963011683	dimerization interface (closed form) [polypeptide binding]; other site
1118963011684	ribulokinase; Provisional; Region: PRK04123
1118963011685	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1118963011686	N- and C-terminal domain interface [polypeptide binding]; other site
1118963011687	active site
1118963011688	MgATP binding site [chemical binding]; other site
1118963011689	catalytic site [active]
1118963011690	metal binding site [ion binding]; metal-binding site
1118963011691	carbohydrate binding site [chemical binding]; other site
1118963011692	homodimer interface [polypeptide binding]; other site
1118963011693	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
1118963011694	intersubunit interface [polypeptide binding]; other site
1118963011695	active site
1118963011696	Zn2+ binding site [ion binding]; other site
1118963011697	L-arabinose isomerase; Provisional; Region: PRK02929
1118963011698	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
1118963011699	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
1118963011700	trimer interface [polypeptide binding]; other site
1118963011701	putative substrate binding site [chemical binding]; other site
1118963011702	putative metal binding site [ion binding]; other site
1118963011703	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
1118963011704	active site
1118963011705	catalytic residues [active]
1118963011706	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963011707	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963011708	DNA binding site [nucleotide binding]
1118963011709	domain linker motif; other site
1118963011710	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963011711	dimerization interface [polypeptide binding]; other site
1118963011712	ligand binding site [chemical binding]; other site
1118963011713	Domain of unknown function (DUF718); Region: DUF718; pfam05336
1118963011714	L-rhamnose isomerase (RhaA); Region: RhaA; cl19165
1118963011715	short chain dehydrogenase; Validated; Region: PRK08324
1118963011716	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
1118963011717	active site
1118963011718	intersubunit interface [polypeptide binding]; other site
1118963011719	Zn2+ binding site [ion binding]; other site
1118963011720	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963011721	NAD(P) binding site [chemical binding]; other site
1118963011722	active site
1118963011723	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
1118963011724	N- and C-terminal domain interface [polypeptide binding]; other site
1118963011725	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
1118963011726	active site
1118963011727	putative catalytic site [active]
1118963011728	metal binding site [ion binding]; metal-binding site
1118963011729	ATP binding site [chemical binding]; other site
1118963011730	carbohydrate binding site [chemical binding]; other site
1118963011731	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963011732	non-specific DNA binding site [nucleotide binding]; other site
1118963011733	salt bridge; other site
1118963011734	sequence-specific DNA binding site [nucleotide binding]; other site
1118963011735	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1118963011736	tetramerization interface [polypeptide binding]; other site
1118963011737	active site
1118963011738	Predicted permeases [General function prediction only]; Region: COG0679
1118963011739	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1118963011740	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1118963011741	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1118963011742	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1118963011743	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1118963011744	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1118963011745	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1118963011746	substrate binding pocket [chemical binding]; other site
1118963011747	membrane-bound complex binding site; other site
1118963011748	hinge residues; other site
1118963011749	threonine dehydratase; Provisional; Region: PRK08246
1118963011750	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963011751	catalytic residue [active]
1118963011752	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1118963011753	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963011754	Coenzyme A binding pocket [chemical binding]; other site
1118963011755	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1118963011756	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963011757	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963011758	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
1118963011759	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
1118963011760	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
1118963011761	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
1118963011762	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1118963011763	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1118963011764	substrate binding pocket [chemical binding]; other site
1118963011765	membrane-bound complex binding site; other site
1118963011766	hinge residues; other site
1118963011767	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1118963011768	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1118963011769	Walker A/P-loop; other site
1118963011770	ATP binding site [chemical binding]; other site
1118963011771	Q-loop/lid; other site
1118963011772	ABC transporter signature motif; other site
1118963011773	Walker B; other site
1118963011774	D-loop; other site
1118963011775	H-loop/switch region; other site
1118963011776	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1118963011777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963011778	dimer interface [polypeptide binding]; other site
1118963011779	conserved gate region; other site
1118963011780	putative PBP binding loops; other site
1118963011781	ABC-ATPase subunit interface; other site
1118963011782	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1118963011783	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963011784	Coenzyme A binding pocket [chemical binding]; other site
1118963011785	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1118963011786	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1118963011787	Walker A motif; other site
1118963011788	ATP binding site [chemical binding]; other site
1118963011789	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1118963011790	putative active site [active]
1118963011791	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1118963011792	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
1118963011793	Copper resistance protein D; Region: CopD; cl00563
1118963011794	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1118963011795	Bacteriophage SPO1-encoded TF1 binds and bends DNA; Region: SPO1_TF1_like; cd14435
1118963011796	putative DNA binding site [nucleotide binding]; other site
1118963011797	dimer interface [polypeptide binding]; other site
1118963011798	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1118963011799	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1118963011800	Patatin-like phospholipase; Region: Patatin; pfam01734
1118963011801	active site
1118963011802	nucleophile elbow; other site
1118963011803	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963011804	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963011805	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1118963011806	DNA binding site [nucleotide binding]
1118963011807	Bacterial transcriptional activator domain; Region: BTAD; smart01043
1118963011808	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1118963011809	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1118963011810	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1118963011811	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
1118963011812	active site
1118963011813	catalytic triad [active]
1118963011814	oxyanion hole [active]
1118963011815	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963011816	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963011817	YCII-related domain; Region: YCII; cl00999
1118963011818	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
1118963011819	active site
1118963011820	catalytic triad [active]
1118963011821	oxyanion hole [active]
1118963011822	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
1118963011823	active site
1118963011824	catalytic triad [active]
1118963011825	oxyanion hole [active]
1118963011826	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1118963011827	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1118963011828	FAD binding pocket [chemical binding]; other site
1118963011829	FAD binding motif [chemical binding]; other site
1118963011830	phosphate binding motif [ion binding]; other site
1118963011831	NAD binding pocket [chemical binding]; other site
1118963011832	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1118963011833	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1118963011834	Walker A/P-loop; other site
1118963011835	ATP binding site [chemical binding]; other site
1118963011836	Q-loop/lid; other site
1118963011837	ABC transporter signature motif; other site
1118963011838	Walker B; other site
1118963011839	D-loop; other site
1118963011840	H-loop/switch region; other site
1118963011841	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1118963011842	ABC-ATPase subunit  interface; other site
1118963011843	dimer interface [polypeptide binding]; other site
1118963011844	putative PBP binding regions; other site
1118963011845	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1118963011846	ABC-ATPase subunit  interface; other site
1118963011847	dimer interface [polypeptide binding]; other site
1118963011848	putative PBP binding regions; other site
1118963011849	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1118963011850	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1118963011851	siderophore binding site; other site
1118963011852	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
1118963011853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
1118963011854	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
1118963011855	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
1118963011856	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
1118963011857	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
1118963011858	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1118963011859	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1118963011860	active site
1118963011861	SEC-C motif; Region: SEC-C; cl19389
1118963011862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012
1118963011863	Chromatin assembly factor complex 1 subunit p60, C-terminal; Region: CAF-1_p60_C; pfam15512
1118963011864	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
1118963011865	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963011866	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963011867	active site
1118963011868	catalytic tetrad [active]
1118963011869	sulfite oxidase; Provisional; Region: PLN00177
1118963011870	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
1118963011871	Moco binding site; other site
1118963011872	metal coordination site [ion binding]; other site
1118963011873	dimerization interface [polypeptide binding]; other site
1118963011874	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963011875	active site
1118963011876	catalytic tetrad [active]
1118963011877	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1118963011878	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1118963011879	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963011880	NAD(P) binding site [chemical binding]; other site
1118963011881	active site
1118963011882	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1118963011883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963011884	S-adenosylmethionine binding site [chemical binding]; other site
1118963011885	PQQ-like domain; Region: PQQ_2; pfam13360
1118963011886	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1118963011887	active site
1118963011888	Trp docking motif [polypeptide binding]; other site
1118963011889	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1118963011890	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1118963011891	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1118963011892	Arginase family; Region: Arginase; pfam00491
1118963011893	active site
1118963011894	metal binding site [ion binding]; metal-binding site
1118963011895	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1118963011896	RNA binding surface [nucleotide binding]; other site
1118963011897	UV excision repair protein Rad23; Region: rad23; TIGR00601
1118963011898	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1118963011899	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1118963011900	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963011901	DNA-binding site [nucleotide binding]; DNA binding site
1118963011902	FCD domain; Region: FCD; pfam07729
1118963011903	L-asparaginase II; Region: Asparaginase_II; pfam06089
1118963011904	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1118963011905	Aspartase; Region: Aspartase; cd01357
1118963011906	active sites [active]
1118963011907	tetramer interface [polypeptide binding]; other site
1118963011908	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1118963011909	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1118963011910	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963011911	DNA-binding site [nucleotide binding]; DNA binding site
1118963011912	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1118963011913	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963011914	active site
1118963011915	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1118963011916	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
1118963011917	active site
1118963011918	catalytic tetrad [active]
1118963011919	Domain of unknown function (DUF718); Region: DUF718; pfam05336
1118963011920	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
1118963011921	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
1118963011922	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
1118963011923	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1118963011924	putative active site pocket [active]
1118963011925	metal binding site [ion binding]; metal-binding site
1118963011926	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1118963011927	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1118963011928	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963011929	classical (c) SDRs; Region: SDR_c; cd05233
1118963011930	NAD(P) binding site [chemical binding]; other site
1118963011931	active site
1118963011932	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963011933	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963011934	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963011935	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963011936	Coenzyme A binding pocket [chemical binding]; other site
1118963011937	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1118963011938	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963011939	Walker A motif; other site
1118963011940	ATP binding site [chemical binding]; other site
1118963011941	Walker B motif; other site
1118963011942	arginine finger; other site
1118963011943	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
1118963011944	HD domain; Region: HD_4; pfam13328
1118963011945	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1118963011946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963011947	NAD(P) binding site [chemical binding]; other site
1118963011948	active site
1118963011949	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963011950	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963011951	WHG domain; Region: WHG; pfam13305
1118963011952	Beta-lactamase; Region: Beta-lactamase; pfam00144
1118963011953	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1118963011954	active site
1118963011955	nucleotide binding site [chemical binding]; other site
1118963011956	HIGH motif; other site
1118963011957	KMSKS motif; other site
1118963011958	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963011959	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963011960	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1118963011961	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963011962	putative DNA binding site [nucleotide binding]; other site
1118963011963	putative Zn2+ binding site [ion binding]; other site
1118963011964	AsnC family; Region: AsnC_trans_reg; pfam01037
1118963011965	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1118963011966	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1118963011967	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
1118963011968	putative hydrophobic ligand binding site [chemical binding]; other site
1118963011969	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963011970	dimerization interface [polypeptide binding]; other site
1118963011971	putative DNA binding site [nucleotide binding]; other site
1118963011972	putative Zn2+ binding site [ion binding]; other site
1118963011973	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
1118963011974	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963011975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963011976	active site
1118963011977	phosphorylation site [posttranslational modification]
1118963011978	intermolecular recognition site; other site
1118963011979	dimerization interface [polypeptide binding]; other site
1118963011980	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963011981	DNA binding residues [nucleotide binding]
1118963011982	dimerization interface [polypeptide binding]; other site
1118963011983	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1118963011984	Histidine kinase; Region: HisKA_3; pfam07730
1118963011985	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963011986	ATP binding site [chemical binding]; other site
1118963011987	Mg2+ binding site [ion binding]; other site
1118963011988	G-X-G motif; other site
1118963011989	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963011990	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963011991	putative Zn2+ binding site [ion binding]; other site
1118963011992	putative DNA binding site [nucleotide binding]; other site
1118963011993	dimerization interface [polypeptide binding]; other site
1118963011994	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963011995	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1118963011996	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1118963011997	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1118963011998	active site
1118963011999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012000	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963012001	putative substrate translocation pore; other site
1118963012002	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1118963012003	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963012004	DNA-binding site [nucleotide binding]; DNA binding site
1118963012005	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1118963012006	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1118963012007	dimer interface [polypeptide binding]; other site
1118963012008	active site
1118963012009	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1118963012010	folate binding site [chemical binding]; other site
1118963012011	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
1118963012012	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1118963012013	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963012014	sarcosine oxidase, delta subunit family, heterotetrameric form; Region: soxD; TIGR01374
1118963012015	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
1118963012016	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1118963012017	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1118963012018	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1118963012019	Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893
1118963012020	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1118963012021	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1118963012022	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1118963012023	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1118963012024	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1118963012025	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1118963012026	putative active site [active]
1118963012027	putative substrate binding site [chemical binding]; other site
1118963012028	putative cosubstrate binding site; other site
1118963012029	catalytic site [active]
1118963012030	Protein of unknown function (DUF456); Region: DUF456; pfam04306
1118963012031	Sulfatase; Region: Sulfatase; cl19157
1118963012032	Sulfatase; Region: Sulfatase; cl19157
1118963012033	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1118963012034	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1118963012035	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1118963012036	NAD(P) binding pocket [chemical binding]; other site
1118963012037	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963012038	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963012039	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012040	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012041	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012042	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012043	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012044	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012045	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012046	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012047	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012048	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963012049	putative substrate translocation pore; other site
1118963012050	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1118963012051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012052	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963012053	putative substrate translocation pore; other site
1118963012054	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
1118963012055	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1118963012056	active sites [active]
1118963012057	tetramer interface [polypeptide binding]; other site
1118963012058	urocanate hydratase; Provisional; Region: PRK05414
1118963012059	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1118963012060	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963012061	dimer interface [polypeptide binding]; other site
1118963012062	conserved gate region; other site
1118963012063	putative PBP binding loops; other site
1118963012064	ABC-ATPase subunit interface; other site
1118963012065	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963012066	dimer interface [polypeptide binding]; other site
1118963012067	conserved gate region; other site
1118963012068	putative PBP binding loops; other site
1118963012069	ABC-ATPase subunit interface; other site
1118963012070	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1118963012071	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963012072	Walker A/P-loop; other site
1118963012073	ATP binding site [chemical binding]; other site
1118963012074	Q-loop/lid; other site
1118963012075	ABC transporter signature motif; other site
1118963012076	Walker B; other site
1118963012077	D-loop; other site
1118963012078	H-loop/switch region; other site
1118963012079	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1118963012080	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963012081	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963012082	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963012083	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1118963012084	allantoate amidohydrolase; Reviewed; Region: PRK09290
1118963012085	active site
1118963012086	metal binding site [ion binding]; metal-binding site
1118963012087	dimer interface [polypeptide binding]; other site
1118963012088	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
1118963012089	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963012090	active site
1118963012091	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1118963012092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012093	putative substrate translocation pore; other site
1118963012094	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1118963012095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012096	putative substrate translocation pore; other site
1118963012097	MarR family; Region: MarR_2; cl17246
1118963012098	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963012099	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963012100	putative DNA binding site [nucleotide binding]; other site
1118963012101	putative Zn2+ binding site [ion binding]; other site
1118963012102	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1118963012103	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963012104	Coenzyme A binding pocket [chemical binding]; other site
1118963012105	Predicted transcriptional regulators [Transcription]; Region: COG1695
1118963012106	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1118963012107	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1118963012108	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963012109	Walker A/P-loop; other site
1118963012110	ATP binding site [chemical binding]; other site
1118963012111	Q-loop/lid; other site
1118963012112	ABC transporter signature motif; other site
1118963012113	Walker B; other site
1118963012114	D-loop; other site
1118963012115	H-loop/switch region; other site
1118963012116	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1118963012117	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1118963012118	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1118963012119	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963012120	Predicted membrane protein [Function unknown]; Region: COG1470
1118963012121	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1118963012122	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1118963012123	Walker A/P-loop; other site
1118963012124	ATP binding site [chemical binding]; other site
1118963012125	Q-loop/lid; other site
1118963012126	ABC transporter signature motif; other site
1118963012127	Walker B; other site
1118963012128	D-loop; other site
1118963012129	H-loop/switch region; other site
1118963012130	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1118963012131	ABC-ATPase subunit  interface; other site
1118963012132	dimer interface [polypeptide binding]; other site
1118963012133	putative PBP binding regions; other site
1118963012134	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1118963012135	ABC-ATPase subunit  interface; other site
1118963012136	dimer interface [polypeptide binding]; other site
1118963012137	putative PBP binding regions; other site
1118963012138	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1118963012139	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1118963012140	putative ligand binding residues [chemical binding]; other site
1118963012141	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1118963012142	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1118963012143	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1118963012144	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
1118963012145	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1118963012146	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1118963012147	active site
1118963012148	P-loop; other site
1118963012149	phosphorylation site [posttranslational modification]
1118963012150	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1118963012151	active site
1118963012152	phosphorylation site [posttranslational modification]
1118963012153	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963012154	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963012155	WHG domain; Region: WHG; pfam13305
1118963012156	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
1118963012157	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1118963012158	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1118963012159	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1118963012160	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1118963012161	dimerization domain swap beta strand [polypeptide binding]; other site
1118963012162	regulatory protein interface [polypeptide binding]; other site
1118963012163	active site
1118963012164	regulatory phosphorylation site [posttranslational modification]; other site
1118963012165	Helix-turn-helix domain; Region: HTH_17; pfam12728
1118963012166	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1118963012167	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1118963012168	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963012169	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963012170	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
1118963012171	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
1118963012172	active site
1118963012173	DNA binding site [nucleotide binding]
1118963012174	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
1118963012175	DNA binding site [nucleotide binding]
1118963012176	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
1118963012177	GAF domain; Region: GAF_3; pfam13492
1118963012178	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1118963012179	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1118963012180	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1118963012181	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1118963012182	hexamer interface [polypeptide binding]; other site
1118963012183	ligand binding site [chemical binding]; other site
1118963012184	putative active site [active]
1118963012185	NAD(P) binding site [chemical binding]; other site
1118963012186	superantigen-like protein; Reviewed; Region: PRK13042
1118963012187	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1118963012188	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1118963012189	DNA binding residues [nucleotide binding]
1118963012190	putative oxidoreductase; Provisional; Region: PRK11579
1118963012191	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1118963012192	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1118963012193	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1118963012194	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1118963012195	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1118963012196	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963012197	Walker A/P-loop; other site
1118963012198	ATP binding site [chemical binding]; other site
1118963012199	Q-loop/lid; other site
1118963012200	ABC transporter signature motif; other site
1118963012201	Walker B; other site
1118963012202	D-loop; other site
1118963012203	H-loop/switch region; other site
1118963012204	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1118963012205	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963012206	Walker A/P-loop; other site
1118963012207	ATP binding site [chemical binding]; other site
1118963012208	Q-loop/lid; other site
1118963012209	ABC transporter signature motif; other site
1118963012210	Walker B; other site
1118963012211	D-loop; other site
1118963012212	H-loop/switch region; other site
1118963012213	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1118963012214	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1118963012215	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1118963012216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963012217	dimer interface [polypeptide binding]; other site
1118963012218	conserved gate region; other site
1118963012219	putative PBP binding loops; other site
1118963012220	ABC-ATPase subunit interface; other site
1118963012221	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1118963012222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963012223	dimer interface [polypeptide binding]; other site
1118963012224	conserved gate region; other site
1118963012225	putative PBP binding loops; other site
1118963012226	ABC-ATPase subunit interface; other site
1118963012227	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963012228	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963012229	Predicted flavoprotein [General function prediction only]; Region: COG0431
1118963012230	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
1118963012231	Sporulation and spore germination; Region: Germane; pfam10646
1118963012232	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
1118963012233	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1118963012234	tetramer interface [polypeptide binding]; other site
1118963012235	active site
1118963012236	Mg2+/Mn2+ binding site [ion binding]; other site
1118963012237	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1118963012238	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963012239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963012240	homodimer interface [polypeptide binding]; other site
1118963012241	catalytic residue [active]
1118963012242	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963012243	Ligand Binding Site [chemical binding]; other site
1118963012244	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963012245	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963012246	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963012247	Amidohydrolase; Region: Amidohydro_4; pfam13147
1118963012248	active site
1118963012249	PAP2 superfamily; Region: PAP2; pfam01569
1118963012250	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1118963012251	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1118963012252	E3 interaction surface; other site
1118963012253	lipoyl attachment site [posttranslational modification]; other site
1118963012254	e3 binding domain; Region: E3_binding; pfam02817
1118963012255	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1118963012256	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1118963012257	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1118963012258	alpha subunit interface [polypeptide binding]; other site
1118963012259	TPP binding site [chemical binding]; other site
1118963012260	heterodimer interface [polypeptide binding]; other site
1118963012261	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1118963012262	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1118963012263	tetramer interface [polypeptide binding]; other site
1118963012264	TPP-binding site [chemical binding]; other site
1118963012265	heterodimer interface [polypeptide binding]; other site
1118963012266	phosphorylation loop region [posttranslational modification]
1118963012267	putative aminotransferase; Provisional; Region: PRK03321
1118963012268	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963012269	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963012270	homodimer interface [polypeptide binding]; other site
1118963012271	catalytic residue [active]
1118963012272	Membrane protein of unknown function; Region: DUF360; pfam04020
1118963012273	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1118963012274	nucleophilic elbow; other site
1118963012275	catalytic triad; other site
1118963012276	adenylosuccinate lyase; Provisional; Region: PRK09285
1118963012277	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1118963012278	tetramer interface [polypeptide binding]; other site
1118963012279	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1118963012280	catalytic core [active]
1118963012281	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963012282	Coenzyme A binding pocket [chemical binding]; other site
1118963012283	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1118963012284	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1118963012285	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963012286	NAD(P) binding site [chemical binding]; other site
1118963012287	active site
1118963012288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012289	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963012290	putative substrate translocation pore; other site
1118963012291	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
1118963012292	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1118963012293	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1118963012294	putative active site [active]
1118963012295	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
1118963012296	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963012297	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1118963012298	putative dimerization interface [polypeptide binding]; other site
1118963012299	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
1118963012300	aspartate aminotransferase; Provisional; Region: PRK06107
1118963012301	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1118963012302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963012303	homodimer interface [polypeptide binding]; other site
1118963012304	catalytic residue [active]
1118963012305	SnoaL-like domain; Region: SnoaL_2; pfam12680
1118963012306	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1118963012307	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1118963012308	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
1118963012309	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
1118963012310	tetramer interface [polypeptide binding]; other site
1118963012311	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
1118963012312	tetramer interface [polypeptide binding]; other site
1118963012313	active site
1118963012314	metal binding site [ion binding]; metal-binding site
1118963012315	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
1118963012316	NAD binding site [chemical binding]; other site
1118963012317	catalytic residues [active]
1118963012318	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1118963012319	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963012320	DNA-binding site [nucleotide binding]; DNA binding site
1118963012321	FCD domain; Region: FCD; pfam07729
1118963012322	hypothetical protein; Provisional; Region: PRK12764
1118963012323	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1118963012324	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
1118963012325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1118963012326	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1118963012327	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963012328	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1118963012329	catalytic site [active]
1118963012330	CsbD-like; Region: CsbD; pfam05532
1118963012331	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1118963012332	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1118963012333	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1118963012334	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1118963012335	catalytic triad [active]
1118963012336	conserved cis-peptide bond; other site
1118963012337	oxidoreductase; Provisional; Region: PRK06128
1118963012338	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963012339	NAD(P) binding site [chemical binding]; other site
1118963012340	active site
1118963012341	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1118963012342	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1118963012343	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1118963012344	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
1118963012345	Asp23 family; Region: Asp23; pfam03780
1118963012346	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1118963012347	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1118963012348	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1118963012349	DNA binding residues [nucleotide binding]
1118963012350	Asp23 family; Region: Asp23; pfam03780
1118963012351	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1118963012352	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1118963012353	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1118963012354	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1118963012355	dimerization interface [polypeptide binding]; other site
1118963012356	ligand binding site [chemical binding]; other site
1118963012357	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963012358	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963012359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963012360	dimer interface [polypeptide binding]; other site
1118963012361	conserved gate region; other site
1118963012362	putative PBP binding loops; other site
1118963012363	ABC-ATPase subunit interface; other site
1118963012364	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963012365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963012366	dimer interface [polypeptide binding]; other site
1118963012367	conserved gate region; other site
1118963012368	putative PBP binding loops; other site
1118963012369	ABC-ATPase subunit interface; other site
1118963012370	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
1118963012371	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1118963012372	putative ligand binding site [chemical binding]; other site
1118963012373	putative NAD binding site [chemical binding]; other site
1118963012374	catalytic site [active]
1118963012375	SpoIIAA-like; Region: SpoIIAA-like; pfam11964
1118963012376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012377	H+ Antiporter protein; Region: 2A0121; TIGR00900
1118963012378	putative substrate translocation pore; other site
1118963012379	GAF domain; Region: GAF; pfam01590
1118963012380	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1118963012381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1118963012382	dimer interface [polypeptide binding]; other site
1118963012383	phosphorylation site [posttranslational modification]
1118963012384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963012385	ATP binding site [chemical binding]; other site
1118963012386	Mg2+ binding site [ion binding]; other site
1118963012387	G-X-G motif; other site
1118963012388	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1118963012389	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1118963012390	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1118963012391	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1118963012392	active site
1118963012393	ATP binding site [chemical binding]; other site
1118963012394	substrate binding site [chemical binding]; other site
1118963012395	activation loop (A-loop); other site
1118963012396	TetR family transcriptional regulator; Provisional; Region: PRK14996
1118963012397	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963012398	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1118963012399	Na binding site [ion binding]; other site
1118963012400	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1118963012401	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1118963012402	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1118963012403	active site
1118963012404	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963012405	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963012406	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1118963012407	catalytic core [active]
1118963012408	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1118963012409	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1118963012410	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1118963012411	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1118963012412	active site
1118963012413	catalytic triad [active]
1118963012414	dimer interface [polypeptide binding]; other site
1118963012415	ZIP Zinc transporter; Region: Zip; cl00437
1118963012416	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1118963012417	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963012418	NAD(P) binding site [chemical binding]; other site
1118963012419	putative active site [active]
1118963012420	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1118963012421	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963012422	non-specific DNA binding site [nucleotide binding]; other site
1118963012423	salt bridge; other site
1118963012424	sequence-specific DNA binding site [nucleotide binding]; other site
1118963012425	Cupin domain; Region: Cupin_2; pfam07883
1118963012426	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
1118963012427	EamA-like transporter family; Region: EamA; pfam00892
1118963012428	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1118963012429	inhibitor site; inhibition site
1118963012430	active site
1118963012431	dimer interface [polypeptide binding]; other site
1118963012432	catalytic residue [active]
1118963012433	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1118963012434	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
1118963012435	putative NAD(P) binding site [chemical binding]; other site
1118963012436	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1118963012437	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963012438	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1118963012439	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1118963012440	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1118963012441	PRC-barrel domain; Region: PRC; pfam05239
1118963012442	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
1118963012443	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1118963012444	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1118963012445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963012446	catalytic residue [active]
1118963012447	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1118963012448	putative dimer interface [polypeptide binding]; other site
1118963012449	putative active site [active]
1118963012450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012451	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963012452	putative substrate translocation pore; other site
1118963012453	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1118963012454	salt bridge; other site
1118963012455	non-specific DNA binding site [nucleotide binding]; other site
1118963012456	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1118963012457	sequence-specific DNA binding site [nucleotide binding]; other site
1118963012458	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1118963012459	active site
1118963012460	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1118963012461	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1118963012462	DNA binding residues [nucleotide binding]
1118963012463	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1118963012464	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1118963012465	active site
1118963012466	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1118963012467	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
1118963012468	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963012469	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963012470	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963012471	benzoate transport; Region: 2A0115; TIGR00895
1118963012472	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012473	putative substrate translocation pore; other site
1118963012474	Hpt domain; Region: Hpt; pfam01627
1118963012475	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1118963012476	Catalytic site [active]
1118963012477	Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780
1118963012478	ZIP Zinc transporter; Region: Zip; cl00437
1118963012479	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1118963012480	Short C-terminal domain; Region: SHOCT; pfam09851
1118963012481	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1118963012482	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1118963012483	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1118963012484	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
1118963012485	putative active site [active]
1118963012486	catalytic site [active]
1118963012487	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
1118963012488	putative active site [active]
1118963012489	catalytic site [active]
1118963012490	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1118963012491	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1118963012492	AAA domain; Region: AAA_22; pfam13401
1118963012493	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1118963012494	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1118963012495	active site
1118963012496	ATP binding site [chemical binding]; other site
1118963012497	substrate binding site [chemical binding]; other site
1118963012498	activation loop (A-loop); other site
1118963012499	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963012500	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1118963012501	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1118963012502	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1118963012503	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1118963012504	lipoyl synthase; Provisional; Region: PRK05481
1118963012505	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1118963012506	FeS/SAM binding site; other site
1118963012507	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1118963012508	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1118963012509	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1118963012510	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1118963012511	dimer interface [polypeptide binding]; other site
1118963012512	active site
1118963012513	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1118963012514	folate binding site [chemical binding]; other site
1118963012515	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1118963012516	lipoyl attachment site [posttranslational modification]; other site
1118963012517	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1118963012518	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1118963012519	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1118963012520	glycine dehydrogenase; Provisional; Region: PRK05367
1118963012521	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1118963012522	tetramer interface [polypeptide binding]; other site
1118963012523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1118963012524	catalytic residue [active]
1118963012525	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
1118963012526	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1118963012527	catalytic residue [active]
1118963012528	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1118963012529	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1118963012530	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1118963012531	oligomer interface [polypeptide binding]; other site
1118963012532	putative active site [active]
1118963012533	Mn binding site [ion binding]; other site
1118963012534	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1118963012535	Na binding site [ion binding]; other site
1118963012536	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1118963012537	NAD(P) binding site [chemical binding]; other site
1118963012538	catalytic residues [active]
1118963012539	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
1118963012540	FAD binding domain; Region: FAD_binding_4; pfam01565
1118963012541	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1118963012542	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1118963012543	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
1118963012544	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1118963012545	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
1118963012546	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1118963012547	NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566
1118963012548	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1118963012549	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1118963012550	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1118963012551	homodimer interface [polypeptide binding]; other site
1118963012552	ligand binding site [chemical binding]; other site
1118963012553	NAD(P) binding site [chemical binding]; other site
1118963012554	trimer interface B [polypeptide binding]; other site
1118963012555	trimer interface A [polypeptide binding]; other site
1118963012556	Predicted flavoprotein [General function prediction only]; Region: COG0431
1118963012557	superantigen-like protein; Reviewed; Region: PRK13042
1118963012558	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1118963012559	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963012560	active site
1118963012561	motif I; other site
1118963012562	motif II; other site
1118963012563	galactonate dehydratase; Provisional; Region: PRK14017
1118963012564	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1118963012565	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
1118963012566	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1118963012567	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1118963012568	PaaX-like protein; Region: PaaX; pfam07848
1118963012569	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1118963012570	microcin C ABC transporter permease; Provisional; Region: PRK15021
1118963012571	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1118963012572	active site
1118963012573	benzoate transport; Region: 2A0115; TIGR00895
1118963012574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012575	putative substrate translocation pore; other site
1118963012576	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
1118963012577	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963012578	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1118963012579	active site
1118963012580	FMN binding site [chemical binding]; other site
1118963012581	substrate binding site [chemical binding]; other site
1118963012582	homotetramer interface [polypeptide binding]; other site
1118963012583	catalytic residue [active]
1118963012584	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1118963012585	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1118963012586	acyl-activating enzyme (AAE) consensus motif; other site
1118963012587	AMP binding site [chemical binding]; other site
1118963012588	active site
1118963012589	CoA binding site [chemical binding]; other site
1118963012590	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1118963012591	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1118963012592	active site
1118963012593	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1118963012594	catalytic triad [active]
1118963012595	dimer interface [polypeptide binding]; other site
1118963012596	Cupin domain; Region: Cupin_2; cl17218
1118963012597	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1118963012598	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1118963012599	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1118963012600	homotrimer interaction site [polypeptide binding]; other site
1118963012601	putative active site [active]
1118963012602	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1118963012603	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1118963012604	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1118963012605	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963012606	Coenzyme A transferase; Region: CoA_trans; cl17247
1118963012607	Coenzyme A transferase; Region: CoA_trans; cl17247
1118963012608	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1118963012609	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1118963012610	dimer interface [polypeptide binding]; other site
1118963012611	active site
1118963012612	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1118963012613	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963012614	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963012615	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
1118963012616	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1118963012617	tetramer interface [polypeptide binding]; other site
1118963012618	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
1118963012619	heterodimer interface [polypeptide binding]; other site
1118963012620	active site
1118963012621	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
1118963012622	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
1118963012623	active site
1118963012624	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963012625	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963012626	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1118963012627	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1118963012628	active site
1118963012629	metal binding site [ion binding]; metal-binding site
1118963012630	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1118963012631	active site
1118963012632	Fe binding site [ion binding]; other site
1118963012633	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
1118963012634	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1118963012635	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1118963012636	shikimate binding site; other site
1118963012637	NAD(P) binding site [chemical binding]; other site
1118963012638	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963012639	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963012640	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963012641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012642	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963012643	putative substrate translocation pore; other site
1118963012644	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012645	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012646	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012647	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012648	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012649	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012650	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963012651	Ubiquitin-like proteins; Region: UBQ; cl00155
1118963012652	charged pocket; other site
1118963012653	hydrophobic patch; other site
1118963012654	VPS10 domain; Region: VPS10; smart00602
1118963012655	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1118963012656	metal binding site [ion binding]; metal-binding site
1118963012657	active site
1118963012658	I-site; other site
1118963012659	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1118963012660	tetramer interface [polypeptide binding]; other site
1118963012661	active site
1118963012662	Mg2+/Mn2+ binding site [ion binding]; other site
1118963012663	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1118963012664	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1118963012665	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1118963012666	dimerization interface [polypeptide binding]; other site
1118963012667	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1118963012668	Ligand Binding Site [chemical binding]; other site
1118963012669	GntP family permease; Region: GntP_permease; pfam02447
1118963012670	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1118963012671	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1118963012672	Entner-Doudoroff aldolase; Region: eda; TIGR01182
1118963012673	active site
1118963012674	intersubunit interface [polypeptide binding]; other site
1118963012675	catalytic residue [active]
1118963012676	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
1118963012677	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1118963012678	active site
1118963012679	putative substrate binding pocket [chemical binding]; other site
1118963012680	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1118963012681	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1118963012682	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1118963012683	catalytic residue [active]
1118963012684	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1118963012685	substrate binding site [chemical binding]; other site
1118963012686	ATP binding site [chemical binding]; other site
1118963012687	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963012688	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963012689	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963012690	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1118963012691	homotrimer interaction site [polypeptide binding]; other site
1118963012692	putative active site [active]
1118963012693	Predicted permeases [General function prediction only]; Region: COG0679
1118963012694	LssY C-terminus; Region: LssY_C; pfam14067
1118963012695	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1118963012696	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963012697	NAD(P) binding site [chemical binding]; other site
1118963012698	active site
1118963012699	trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455
1118963012700	Homeodomain-like domain; Region: HTH_23; cl17451
1118963012701	Integrase core domain; Region: rve; pfam00665
1118963012702	Integrase core domain; Region: rve_3; pfam13683
1118963012703	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1118963012704	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1118963012705	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1118963012706	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1118963012707	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1118963012708	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1118963012709	putative active site [active]
1118963012710	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
1118963012711	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1118963012712	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459
1118963012713	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1118963012714	putative active site [active]
1118963012715	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1118963012716	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1118963012717	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1118963012718	DNA binding site [nucleotide binding]
1118963012719	domain linker motif; other site
1118963012720	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
1118963012721	putative dimerization interface [polypeptide binding]; other site
1118963012722	putative ligand binding site [chemical binding]; other site
1118963012723	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963012724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963012725	dimer interface [polypeptide binding]; other site
1118963012726	conserved gate region; other site
1118963012727	putative PBP binding loops; other site
1118963012728	ABC-ATPase subunit interface; other site
1118963012729	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1118963012730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963012731	dimer interface [polypeptide binding]; other site
1118963012732	conserved gate region; other site
1118963012733	putative PBP binding loops; other site
1118963012734	ABC-ATPase subunit interface; other site
1118963012735	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963012736	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963012737	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1118963012738	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1118963012739	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1118963012740	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1118963012741	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
1118963012742	Helix-turn-helix domain; Region: HTH_18; pfam12833
1118963012743	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963012744	Probable pheophorbidase; Region: PLN02965; cl17657
1118963012745	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1118963012746	active site residue [active]
1118963012747	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963012748	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1118963012749	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963012750	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
1118963012751	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
1118963012752	active site
1118963012753	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963012754	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963012755	dimer interface [polypeptide binding]; other site
1118963012756	conserved gate region; other site
1118963012757	putative PBP binding loops; other site
1118963012758	ABC-ATPase subunit interface; other site
1118963012759	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1118963012760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963012761	dimer interface [polypeptide binding]; other site
1118963012762	conserved gate region; other site
1118963012763	putative PBP binding loops; other site
1118963012764	ABC-ATPase subunit interface; other site
1118963012765	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1118963012766	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1118963012767	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1118963012768	putative homodimer interface [polypeptide binding]; other site
1118963012769	putative homotetramer interface [polypeptide binding]; other site
1118963012770	putative allosteric switch controlling residues; other site
1118963012771	putative metal binding site [ion binding]; other site
1118963012772	putative homodimer-homodimer interface [polypeptide binding]; other site
1118963012773	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1118963012774	metal-binding site [ion binding]
1118963012775	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1118963012776	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1118963012777	metal-binding site [ion binding]
1118963012778	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1118963012779	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1118963012780	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
1118963012781	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1118963012782	EamA-like transporter family; Region: EamA; pfam00892
1118963012783	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1118963012784	EamA-like transporter family; Region: EamA; pfam00892
1118963012785	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1118963012786	CGNR zinc finger; Region: zf-CGNR; pfam11706
1118963012787	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1118963012788	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1118963012789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
1118963012790	Predicted membrane protein [Function unknown]; Region: COG2259
1118963012791	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1118963012792	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1118963012793	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1118963012794	AAA domain; Region: AAA_22; pfam13401
1118963012795	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1118963012796	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963012797	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963012798	DNA binding residues [nucleotide binding]
1118963012799	dimerization interface [polypeptide binding]; other site
1118963012800	RatA-like protein; Provisional; Region: PRK15316
1118963012801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
1118963012802	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1118963012803	Walker A motif; other site
1118963012804	ATP binding site [chemical binding]; other site
1118963012805	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1118963012806	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963012807	DNA-binding site [nucleotide binding]; DNA binding site
1118963012808	FCD domain; Region: FCD; pfam07729
1118963012809	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1118963012810	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1118963012811	PYR/PP interface [polypeptide binding]; other site
1118963012812	dimer interface [polypeptide binding]; other site
1118963012813	TPP binding site [chemical binding]; other site
1118963012814	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1118963012815	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1118963012816	TPP-binding site [chemical binding]; other site
1118963012817	dimer interface [polypeptide binding]; other site
1118963012818	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963012819	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012820	putative substrate translocation pore; other site
1118963012821	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1118963012822	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1118963012823	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963012824	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1118963012825	NAD(P) binding site [chemical binding]; other site
1118963012826	active site
1118963012827	dihydroxyacetone kinase; Provisional; Region: PRK14479
1118963012828	Dak1 domain; Region: Dak1; cl10557
1118963012829	DAK2 domain; Region: Dak2; pfam02734
1118963012830	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
1118963012831	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1118963012832	replicative DNA helicase; Region: DnaB; TIGR00665
1118963012833	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1118963012834	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1118963012835	Walker A motif; other site
1118963012836	ATP binding site [chemical binding]; other site
1118963012837	Walker B motif; other site
1118963012838	DNA binding loops [nucleotide binding]
1118963012839	hypothetical protein; Provisional; Region: PRK06771
1118963012840	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1118963012841	active site
1118963012842	MepB protein; Region: MepB; cl01985
1118963012843	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
1118963012844	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1118963012845	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
1118963012846	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1118963012847	GntP family permease; Region: GntP_permease; pfam02447
1118963012848	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1118963012849	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962
1118963012850	active site
1118963012851	catalytic residues [active]
1118963012852	metal binding site [ion binding]; metal-binding site
1118963012853	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1118963012854	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1118963012855	dimerization interface [polypeptide binding]; other site
1118963012856	ligand binding site [chemical binding]; other site
1118963012857	NADP binding site [chemical binding]; other site
1118963012858	catalytic site [active]
1118963012859	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1118963012860	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1118963012861	hydrophobic ligand binding site; other site
1118963012862	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
1118963012863	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1118963012864	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1118963012865	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
1118963012866	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1118963012867	S-adenosylmethionine binding site [chemical binding]; other site
1118963012868	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1118963012869	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1118963012870	Bacterial transcriptional regulator; Region: IclR; pfam01614
1118963012871	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1118963012872	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1118963012873	Walker A/P-loop; other site
1118963012874	ATP binding site [chemical binding]; other site
1118963012875	Q-loop/lid; other site
1118963012876	ABC transporter signature motif; other site
1118963012877	Walker B; other site
1118963012878	D-loop; other site
1118963012879	H-loop/switch region; other site
1118963012880	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1118963012881	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
1118963012882	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1118963012883	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1118963012884	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1118963012885	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1118963012886	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1118963012887	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1118963012888	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1118963012889	dimer interface [polypeptide binding]; other site
1118963012890	ssDNA binding site [nucleotide binding]; other site
1118963012891	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1118963012892	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1118963012893	hypothetical protein; Provisional; Region: PRK02237
1118963012894	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1118963012895	Spore germination protein; Region: Spore_permease; cl17796
1118963012896	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
1118963012897	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1118963012898	active site
1118963012899	metal binding site [ion binding]; metal-binding site
1118963012900	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
1118963012901	putative active site [active]
1118963012902	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963012903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963012904	active site
1118963012905	phosphorylation site [posttranslational modification]
1118963012906	intermolecular recognition site; other site
1118963012907	dimerization interface [polypeptide binding]; other site
1118963012908	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963012909	DNA binding residues [nucleotide binding]
1118963012910	dimerization interface [polypeptide binding]; other site
1118963012911	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1118963012912	Histidine kinase; Region: HisKA_3; pfam07730
1118963012913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963012914	ATP binding site [chemical binding]; other site
1118963012915	Mg2+ binding site [ion binding]; other site
1118963012916	G-X-G motif; other site
1118963012917	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1118963012918	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1118963012919	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1118963012920	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1118963012921	Walker A/P-loop; other site
1118963012922	ATP binding site [chemical binding]; other site
1118963012923	Q-loop/lid; other site
1118963012924	ABC transporter signature motif; other site
1118963012925	Walker B; other site
1118963012926	D-loop; other site
1118963012927	H-loop/switch region; other site
1118963012928	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1118963012929	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1118963012930	active site
1118963012931	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
1118963012932	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1118963012933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963012934	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963012935	putative substrate translocation pore; other site
1118963012936	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1118963012937	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1118963012938	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1118963012939	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1118963012940	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963012941	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1118963012942	Beta-lactamase; Region: Beta-lactamase; pfam00144
1118963012943	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1118963012944	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1118963012945	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
1118963012946	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1118963012947	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1118963012948	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
1118963012949	CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596
1118963012950	putative active site [active]
1118963012951	putative catalytic site [active]
1118963012952	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
1118963012953	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
1118963012954	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963012955	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1118963012956	active site
1118963012957	phosphorylation site [posttranslational modification]
1118963012958	intermolecular recognition site; other site
1118963012959	dimerization interface [polypeptide binding]; other site
1118963012960	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963012961	DNA binding residues [nucleotide binding]
1118963012962	dimerization interface [polypeptide binding]; other site
1118963012963	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1118963012964	Histidine kinase; Region: HisKA_3; pfam07730
1118963012965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1118963012966	ATP binding site [chemical binding]; other site
1118963012967	G-X-G motif; other site
1118963012968	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1118963012969	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1118963012970	FtsX-like permease family; Region: FtsX; pfam02687
1118963012971	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1118963012972	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1118963012973	Walker A/P-loop; other site
1118963012974	ATP binding site [chemical binding]; other site
1118963012975	Q-loop/lid; other site
1118963012976	ABC transporter signature motif; other site
1118963012977	Walker B; other site
1118963012978	D-loop; other site
1118963012979	H-loop/switch region; other site
1118963012980	Predicted transcriptional regulators [Transcription]; Region: COG1733
1118963012981	dimerization interface [polypeptide binding]; other site
1118963012982	putative DNA binding site [nucleotide binding]; other site
1118963012983	putative Zn2+ binding site [ion binding]; other site
1118963012984	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1118963012985	NAD(P) binding site [chemical binding]; other site
1118963012986	active site
1118963012987	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1118963012988	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1118963012989	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963012990	Predicted integral membrane protein [Function unknown]; Region: COG5650
1118963012991	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1118963012992	catalytic core [active]
1118963012993	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1118963012994	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
1118963012995	active site
1118963012996	NTP binding site [chemical binding]; other site
1118963012997	metal binding triad [ion binding]; metal-binding site
1118963012998	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1118963012999	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1118963013000	Zn2+ binding site [ion binding]; other site
1118963013001	Mg2+ binding site [ion binding]; other site
1118963013002	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1118963013003	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1118963013004	active site
1118963013005	Ap6A binding site [chemical binding]; other site
1118963013006	nudix motif; other site
1118963013007	metal binding site [ion binding]; metal-binding site
1118963013008	integral membrane protein MviN; Region: mviN; TIGR01695
1118963013009	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1118963013010	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067
1118963013011	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1118963013012	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963013013	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963013014	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1118963013015	catalytic residues [active]
1118963013016	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1118963013017	ParB-like nuclease domain; Region: ParBc; pfam02195
1118963013018	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1118963013019	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1118963013020	nitrogenase reductase; Reviewed; Region: nifH; PRK13233
1118963013021	P-loop; other site
1118963013022	Magnesium ion binding site [ion binding]; other site
1118963013023	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1118963013024	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
1118963013025	G-X-X-G motif; other site
1118963013026	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1118963013027	RxxxH motif; other site
1118963013028	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1118963013029	Haemolytic domain; Region: Haemolytic; pfam01809
1118963013030	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1118963013031	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1118963013032	P-loop; other site
1118963013033	Magnesium ion binding site [ion binding]; other site
1118963013034	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1118963013035	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1118963013036	catalytic residues [active]
1118963013037	catalytic nucleophile [active]
1118963013038	Presynaptic Site I dimer interface [polypeptide binding]; other site
1118963013039	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1118963013040	Synaptic Flat tetramer interface [polypeptide binding]; other site
1118963013041	Synaptic Site I dimer interface [polypeptide binding]; other site
1118963013042	DNA binding site [nucleotide binding]
1118963013043	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
1118963013044	DNA-binding interface [nucleotide binding]; DNA binding site
1118963013045	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
1118963013046	putative hydrophobic ligand binding site [chemical binding]; other site
1118963013047	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151
1118963013048	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1118963013049	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1118963013050	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1118963013051	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1118963013052	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
1118963013053	Domain of unknown function (DUF305); Region: DUF305; pfam03713
1118963013054	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
1118963013055	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
1118963013056	dimerization interface [polypeptide binding]; other site
1118963013057	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1118963013058	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1118963013059	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1118963013060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963013061	putative substrate translocation pore; other site
1118963013062	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1118963013063	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1118963013064	Rhodanese Homology Domain; Region: RHOD; smart00450
1118963013065	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1118963013066	active site residue [active]
1118963013067	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1118963013068	catalytic residues [active]
1118963013069	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1118963013070	active site residue [active]
1118963013071	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1118963013072	active site residue [active]
1118963013073	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1118963013074	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1118963013075	putative homotetramer interface [polypeptide binding]; other site
1118963013076	putative homodimer interface [polypeptide binding]; other site
1118963013077	putative allosteric switch controlling residues; other site
1118963013078	putative metal binding site [ion binding]; other site
1118963013079	putative homodimer-homodimer interface [polypeptide binding]; other site
1118963013080	Domain of unknown function DUF302; Region: DUF302; cl01364
1118963013081	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1118963013082	The first cupredoxin domain of the bacterial laccases similar to Tth-MCO from Thermus Thermophilus; Region: CuRO_1_Tth-MCO_like; cd13853
1118963013083	Domain 2 interface [polypeptide binding]; other site
1118963013084	Domain 3 interface [polypeptide binding]; other site
1118963013085	trinuclear Cu binding site [ion binding]; other site
1118963013086	The second cupredoxin domain of a multicopper oxidase McoC and similar proteins; Region: CuRO_2_McoC_like; cd13881
1118963013087	Domain 1 interface [polypeptide binding]; other site
1118963013088	Domain 3 interface [polypeptide binding]; other site
1118963013089	The third cupredoxin domain of the bacterial laccases similar to Tth-MCO from Thermus Thermophilus; Region: CuRO_3_Tth-MCO_like; cd13900
1118963013090	Domain 2 interface [polypeptide binding]; other site
1118963013091	Domain 1 interface [polypeptide binding]; other site
1118963013092	Type 1 (T1) Cu binding site [ion binding]; other site
1118963013093	trinuclear Cu binding site [ion binding]; other site
1118963013094	H+ Antiporter protein; Region: 2A0121; TIGR00900
1118963013095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963013096	putative substrate translocation pore; other site
1118963013097	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963013098	dimerization interface [polypeptide binding]; other site
1118963013099	putative DNA binding site [nucleotide binding]; other site
1118963013100	putative Zn2+ binding site [ion binding]; other site
1118963013101	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1118963013102	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1118963013103	catalytic residues [active]
1118963013104	catalytic nucleophile [active]
1118963013105	Presynaptic Site I dimer interface [polypeptide binding]; other site
1118963013106	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1118963013107	Synaptic Flat tetramer interface [polypeptide binding]; other site
1118963013108	Synaptic Site I dimer interface [polypeptide binding]; other site
1118963013109	DNA binding site [nucleotide binding]
1118963013110	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
1118963013111	DNA-binding interface [nucleotide binding]; DNA binding site
1118963013112	AAA ATPase domain; Region: AAA_16; pfam13191
1118963013113	Walker A motif; other site
1118963013114	ATP binding site [chemical binding]; other site
1118963013115	translocation protein TolB; Provisional; Region: tolB; PRK03629
1118963013116	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1118963013117	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
1118963013118	Bacterial Ig-like domain; Region: Big_5; pfam13205
1118963013119	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
1118963013120	Bacterial Ig-like domain; Region: Big_5; pfam13205
1118963013121	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
1118963013122	Bacterial Ig-like domain; Region: Big_5; pfam13205
1118963013123	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
1118963013124	CopC domain; Region: CopC; pfam04234
1118963013125	Thioredoxin; Region: Thioredoxin_4; cl17273
1118963013126	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1118963013127	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963013128	dimerization interface [polypeptide binding]; other site
1118963013129	putative DNA binding site [nucleotide binding]; other site
1118963013130	putative Zn2+ binding site [ion binding]; other site
1118963013131	Copper resistance protein D; Region: CopD; pfam05425
1118963013132	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1118963013133	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963013134	putative DNA binding site [nucleotide binding]; other site
1118963013135	putative Zn2+ binding site [ion binding]; other site
1118963013136	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1118963013137	ResB-like family; Region: ResB; pfam05140
1118963013138	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1118963013139	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1118963013140	Peptidase family M23; Region: Peptidase_M23; pfam01551
1118963013141	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1118963013142	Cation transport protein; Region: TrkH; cl17365
1118963013143	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
1118963013144	putative active site [active]
1118963013145	redox center [active]
1118963013146	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1118963013147	catalytic residues [active]
1118963013148	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1118963013149	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
1118963013150	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1118963013151	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1118963013152	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1118963013153	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
1118963013154	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963013155	putative DNA binding site [nucleotide binding]; other site
1118963013156	dimerization interface [polypeptide binding]; other site
1118963013157	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1118963013158	putative Zn2+ binding site [ion binding]; other site
1118963013159	ZIP Zinc transporter; Region: Zip; cl00437
1118963013160	The cupredoxin domain 1 of a two-domain laccase related to nitrite reductase; Region: CuRO_1_2DMCO_NIR_like; cd11024
1118963013161	Domain 2 interface [polypeptide binding]; other site
1118963013162	Type 1 (T1) Cu binding site [ion binding]; other site
1118963013163	trimer interface [polypeptide binding]; other site
1118963013164	trinuclear Cu binding site [ion binding]; other site
1118963013165	Cupredoxin superfamily; Region: Cupredoxin; cl19115
1118963013166	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1118963013167	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1118963013168	Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
1118963013169	FeoA domain; Region: FeoA; pfam04023
1118963013170	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1118963013171	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1118963013172	Domain of unknown function DUF21; Region: DUF21; pfam01595
1118963013173	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1118963013174	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1118963013175	Domain of unknown function DUF21; Region: DUF21; pfam01595
1118963013176	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1118963013177	Transporter associated domain; Region: CorC_HlyC; pfam03471
1118963013178	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1118963013179	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1118963013180	catalytic residues [active]
1118963013181	catalytic nucleophile [active]
1118963013182	Presynaptic Site I dimer interface [polypeptide binding]; other site
1118963013183	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1118963013184	Synaptic Flat tetramer interface [polypeptide binding]; other site
1118963013185	Synaptic Site I dimer interface [polypeptide binding]; other site
1118963013186	DNA binding site [nucleotide binding]
1118963013187	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
1118963013188	DNA-binding interface [nucleotide binding]; DNA binding site
1118963013189	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
1118963013190	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1118963013191	catalytic residues [active]
1118963013192	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1118963013193	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963013194	dimerization interface [polypeptide binding]; other site
1118963013195	putative DNA binding site [nucleotide binding]; other site
1118963013196	putative Zn2+ binding site [ion binding]; other site
1118963013197	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1118963013198	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1118963013199	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963013200	motif II; other site
1118963013201	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
1118963013202	Cadmium resistance transporter; Region: Cad; cl19409
1118963013203	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1118963013204	Thioredoxin; Region: Thioredoxin_4; pfam13462
1118963013205	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
1118963013206	dimerization interface [polypeptide binding]; other site
1118963013207	VPS10 domain; Region: VPS10; smart00602
1118963013208	Domain of unknown function (DUF305); Region: DUF305; pfam03713
1118963013209	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1118963013210	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1118963013211	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1118963013212	active site
1118963013213	motif I; other site
1118963013214	motif II; other site
1118963013215	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1118963013216	mercuric reductase; Region: MerA; TIGR02053
1118963013217	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1118963013218	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
1118963013219	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
1118963013220	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
1118963013221	DNA binding residues [nucleotide binding]
1118963013222	dimer interface [polypeptide binding]; other site
1118963013223	metal binding site [ion binding]; metal-binding site
1118963013224	DinB superfamily; Region: DinB_2; pfam12867
1118963013225	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1118963013226	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1118963013227	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1118963013228	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1118963013229	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
1118963013230	ParB-like nuclease domain; Region: ParBc; pfam02195
1118963013231	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517
1118963013232	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1118963013233	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1118963013234	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1118963013235	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1118963013236	catalytic residues [active]
1118963013237	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1118963013238	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1118963013239	dimer interface [polypeptide binding]; other site
1118963013240	ssDNA binding site [nucleotide binding]; other site
1118963013241	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1118963013242	Staphylococcal nuclease homologues; Region: SNc; smart00318
1118963013243	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1118963013244	Catalytic site; other site
1118963013245	putative transposase OrfB; Reviewed; Region: PHA02517
1118963013246	HTH-like domain; Region: HTH_21; pfam13276
1118963013247	Integrase core domain; Region: rve; pfam00665
1118963013248	Integrase core domain; Region: rve_2; pfam13333
1118963013249	Helix-turn-helix domain; Region: HTH_28; pfam13518
1118963013250	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1118963013251	TrwC relaxase; Region: TrwC; pfam08751
1118963013252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1118963013253	Walker A motif; other site
1118963013254	ATP binding site [chemical binding]; other site
1118963013255	Walker B motif; other site
1118963013256	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
1118963013257	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1118963013258	AAA ATPase domain; Region: AAA_16; pfam13191
1118963013259	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1118963013260	Resolvase, N terminal domain; Region: Resolvase; pfam00239
1118963013261	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1118963013262	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781
1118963013263	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1118963013264	putative DNA binding site [nucleotide binding]; other site
1118963013265	putative Zn2+ binding site [ion binding]; other site
1118963013266	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963013267	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963013268	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1118963013269	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1118963013270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963013271	dimer interface [polypeptide binding]; other site
1118963013272	conserved gate region; other site
1118963013273	putative PBP binding loops; other site
1118963013274	ABC-ATPase subunit interface; other site
1118963013275	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1118963013276	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1118963013277	Walker A/P-loop; other site
1118963013278	ATP binding site [chemical binding]; other site
1118963013279	Q-loop/lid; other site
1118963013280	ABC transporter signature motif; other site
1118963013281	Walker B; other site
1118963013282	D-loop; other site
1118963013283	H-loop/switch region; other site
1118963013284	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1118963013285	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
1118963013286	arylsulfatase; Provisional; Region: PRK13759
1118963013287	Sulfatase; Region: Sulfatase; pfam00884
1118963013288	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1118963013289	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1118963013290	dimer interface [polypeptide binding]; other site
1118963013291	active site
1118963013292	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1118963013293	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1118963013294	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1118963013295	nucleotide binding site [chemical binding]; other site
1118963013296	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1118963013297	substrate binding site [chemical binding]; other site
1118963013298	ATP binding site [chemical binding]; other site
1118963013299	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1118963013300	intersubunit interface [polypeptide binding]; other site
1118963013301	active site
1118963013302	zinc binding site [ion binding]; other site
1118963013303	Na+ binding site [ion binding]; other site
1118963013304	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1118963013305	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1118963013306	Coenzyme A binding pocket [chemical binding]; other site
1118963013307	hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687
1118963013308	Proline racemase; Region: Pro_racemase; pfam05544
1118963013309	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
1118963013310	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1118963013311	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1118963013312	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1118963013313	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1118963013314	DNA binding residues [nucleotide binding]
1118963013315	dimerization interface [polypeptide binding]; other site
1118963013316	Polysaccharide lyase family 8, N terminal alpha-helical domain; Region: Lyase_8_N; pfam08124
1118963013317	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1118963013318	arylsulfatase; Provisional; Region: PRK13759
1118963013319	Homeodomain-like domain; Region: HTH_23; cl17451
1118963013320	Integrase core domain; Region: rve; pfam00665
1118963013321	Integrase core domain; Region: rve_3; pfam13683
1118963013322	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1118963013323	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
1118963013324	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1118963013325	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963013326	FAD dependent oxidoreductase; Region: DAO; pfam01266
1118963013327	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
1118963013328	hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687
1118963013329	Proline racemase; Region: Pro_racemase; pfam05544
1118963013330	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1118963013331	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1118963013332	DNA-binding site [nucleotide binding]; DNA binding site
1118963013333	FCD domain; Region: FCD; pfam07729
1118963013334	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1118963013335	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1118963013336	Walker A/P-loop; other site
1118963013337	ATP binding site [chemical binding]; other site
1118963013338	Q-loop/lid; other site
1118963013339	ABC transporter signature motif; other site
1118963013340	Walker B; other site
1118963013341	D-loop; other site
1118963013342	H-loop/switch region; other site
1118963013343	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1118963013344	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963013345	dimer interface [polypeptide binding]; other site
1118963013346	conserved gate region; other site
1118963013347	putative PBP binding loops; other site
1118963013348	ABC-ATPase subunit interface; other site
1118963013349	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
1118963013350	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963013351	dimer interface [polypeptide binding]; other site
1118963013352	conserved gate region; other site
1118963013353	putative PBP binding loops; other site
1118963013354	ABC-ATPase subunit interface; other site
1118963013355	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1118963013356	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1118963013357	substrate binding pocket [chemical binding]; other site
1118963013358	membrane-bound complex binding site; other site
1118963013359	hinge residues; other site
1118963013360	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1118963013361	inhibitor site; inhibition site
1118963013362	active site
1118963013363	dimer interface [polypeptide binding]; other site
1118963013364	catalytic residue [active]
1118963013365	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1118963013366	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124
1118963013367	metabolite-proton symporter; Region: 2A0106; TIGR00883
1118963013368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963013369	putative substrate translocation pore; other site
1118963013370	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1118963013371	dimer interface [polypeptide binding]; other site
1118963013372	NADP binding site [chemical binding]; other site
1118963013373	catalytic residues [active]
1118963013374	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
1118963013375	proline aminopeptidase P II; Provisional; Region: PRK10879
1118963013376	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1118963013377	active site
1118963013378	Putative lysophospholipase; Region: Hydrolase_4; cl19140
1118963013379	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1118963013380	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963013381	dimer interface [polypeptide binding]; other site
1118963013382	conserved gate region; other site
1118963013383	putative PBP binding loops; other site
1118963013384	ABC-ATPase subunit interface; other site
1118963013385	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1118963013386	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1118963013387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1118963013388	dimer interface [polypeptide binding]; other site
1118963013389	conserved gate region; other site
1118963013390	putative PBP binding loops; other site
1118963013391	ABC-ATPase subunit interface; other site
1118963013392	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1118963013393	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963013394	Walker A/P-loop; other site
1118963013395	ATP binding site [chemical binding]; other site
1118963013396	Q-loop/lid; other site
1118963013397	ABC transporter signature motif; other site
1118963013398	Walker B; other site
1118963013399	D-loop; other site
1118963013400	H-loop/switch region; other site
1118963013401	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1118963013402	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1118963013403	Walker A/P-loop; other site
1118963013404	ATP binding site [chemical binding]; other site
1118963013405	Q-loop/lid; other site
1118963013406	ABC transporter signature motif; other site
1118963013407	Walker B; other site
1118963013408	D-loop; other site
1118963013409	H-loop/switch region; other site
1118963013410	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1118963013411	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
1118963013412	peptide binding site [polypeptide binding]; other site
1118963013413	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1118963013414	Protein of unknown function (DUF917); Region: DUF917; pfam06032
1118963013415	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1118963013416	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1118963013417	benzoate transport; Region: 2A0115; TIGR00895
1118963013418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1118963013419	putative substrate translocation pore; other site
1118963013420	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1118963013421	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1118963013422	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1118963013423	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816
1118963013424	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1118963013425	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1118963013426	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1118963013427	active site
1118963013428	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
1118963013429	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
1118963013430	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1118963013431	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1118963013432	MepB protein; Region: MepB; cl01985
1118963013433	AAA ATPase domain; Region: AAA_16; pfam13191
1118963013434	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1118963013435	active site
1118963013436	Int/Topo IB signature motif; other site
1118963013437	DNA binding site [nucleotide binding]
1118963013438	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1118963013439	integron integrase; Region: integrase_gron; TIGR02249
1118963013440	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1118963013441	active site
1118963013442	DNA binding site [nucleotide binding]
1118963013443	Int/Topo IB signature motif; other site
1118963013444	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1118963013445	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1118963013446	active site
1118963013447	DNA binding site [nucleotide binding]
1118963013448	Int/Topo IB signature motif; other site
1118963013449	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1118963013450	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1118963013451	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963013452	ATP binding site [chemical binding]; other site
1118963013453	putative Mg++ binding site [ion binding]; other site
1118963013454	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963013455	nucleotide binding region [chemical binding]; other site
1118963013456	ATP-binding site [chemical binding]; other site
1118963013457	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1118963013458	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1118963013459	ATP binding site [chemical binding]; other site
1118963013460	putative Mg++ binding site [ion binding]; other site
1118963013461	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1118963013462	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1118963013463	nucleotide binding region [chemical binding]; other site
1118963013464	ATP-binding site [chemical binding]; other site
1118963013465	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
1118963013466	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
1118963013467	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
1118963013468	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
1118963013469	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
1118963013470	Abi-like protein; Region: Abi_2; pfam07751
1118963013471	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1118963013472	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1118963013473	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1118963013474	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
1118963013475	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1118963013476	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1118963013477	active site
1118963013478	catalytic site [active]
1118963013479	substrate binding site [chemical binding]; other site
1118963013480	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1118963013481	Walker A motif; other site
1118963013482	ATP binding site [chemical binding]; other site
1118963013483	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1118963013484	Walker B motif; other site
1118963013485	AAA-like domain; Region: AAA_10; pfam12846
1118963013486	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1118963013487	NAD binding site [chemical binding]; other site
1118963013488	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1118963013489	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1118963013490	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1118963013491	Peptidase family M23; Region: Peptidase_M23; pfam01551