-- dump date 20140618_205544 -- class Genbank::misc_feature -- table misc_feature_note -- id note 930171000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 930171000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171000003 Walker A motif; other site 930171000004 ATP binding site [chemical binding]; other site 930171000005 Walker B motif; other site 930171000006 arginine finger; other site 930171000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 930171000008 DnaA box-binding interface [nucleotide binding]; other site 930171000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 930171000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 930171000011 putative DNA binding surface [nucleotide binding]; other site 930171000012 dimer interface [polypeptide binding]; other site 930171000013 beta-clamp/clamp loader binding surface; other site 930171000014 beta-clamp/translesion DNA polymerase binding surface; other site 930171000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930171000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 930171000017 recombination protein F; Reviewed; Region: recF; PRK00064 930171000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 930171000019 Walker A/P-loop; other site 930171000020 ATP binding site [chemical binding]; other site 930171000021 Q-loop/lid; other site 930171000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171000023 ABC transporter signature motif; other site 930171000024 Walker B; other site 930171000025 D-loop; other site 930171000026 H-loop/switch region; other site 930171000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 930171000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 930171000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 930171000030 anchoring element; other site 930171000031 dimer interface [polypeptide binding]; other site 930171000032 ATP binding site [chemical binding]; other site 930171000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 930171000034 active site 930171000035 putative metal-binding site [ion binding]; other site 930171000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 930171000037 DNA gyrase subunit A; Validated; Region: PRK05560 930171000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 930171000039 CAP-like domain; other site 930171000040 active site 930171000041 primary dimer interface [polypeptide binding]; other site 930171000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930171000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930171000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930171000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930171000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930171000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930171000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 930171000049 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930171000050 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930171000051 active site 930171000052 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 930171000053 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 930171000054 active site 930171000055 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 930171000056 Zn2+ binding site [ion binding]; other site 930171000057 Rhomboid family; Region: Rhomboid; pfam01694 930171000058 Uncharacterized conserved protein [Function unknown]; Region: COG2128 930171000059 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 930171000060 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 930171000061 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 930171000062 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 930171000063 active site 930171000064 catalytic site [active] 930171000065 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 930171000066 Glutamine amidotransferase class-I; Region: GATase; pfam00117 930171000067 glutamine binding [chemical binding]; other site 930171000068 catalytic triad [active] 930171000069 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 930171000070 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930171000071 active site 930171000072 ATP binding site [chemical binding]; other site 930171000073 substrate binding site [chemical binding]; other site 930171000074 activation loop (A-loop); other site 930171000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930171000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930171000077 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930171000078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930171000079 Catalytic domain of Protein Kinases; Region: PKc; cd00180 930171000080 active site 930171000081 ATP binding site [chemical binding]; other site 930171000082 substrate binding site [chemical binding]; other site 930171000083 activation loop (A-loop); other site 930171000084 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 930171000085 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930171000086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930171000087 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 930171000088 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 930171000089 active site 930171000090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 930171000091 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 930171000092 phosphopeptide binding site; other site 930171000093 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 930171000094 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 930171000095 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 930171000096 phosphopeptide binding site; other site 930171000097 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930171000098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171000099 DNA-binding site [nucleotide binding]; DNA binding site 930171000100 FCD domain; Region: FCD; pfam07729 930171000101 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 930171000102 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 930171000103 active site pocket [active] 930171000104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171000105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171000106 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 930171000107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930171000108 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 930171000109 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 930171000110 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 930171000111 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 930171000112 [4Fe-4S] binding site [ion binding]; other site 930171000113 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 930171000114 molybdopterin cofactor binding site; other site 930171000115 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 930171000116 molybdopterin cofactor binding site; other site 930171000117 membrane protein FdrA; Validated; Region: PRK06091 930171000118 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171000119 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 930171000120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 930171000121 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 930171000122 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 930171000123 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930171000124 MarR family; Region: MarR; pfam01047 930171000125 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 930171000126 FAD binding domain; Region: FAD_binding_4; pfam01565 930171000127 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 930171000128 amidase; Validated; Region: PRK06565 930171000129 Amidase; Region: Amidase; cl11426 930171000130 Amidase; Region: Amidase; cl11426 930171000131 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 930171000132 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 930171000133 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171000134 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 930171000135 Na2 binding site [ion binding]; other site 930171000136 putative substrate binding site 1 [chemical binding]; other site 930171000137 Na binding site 1 [ion binding]; other site 930171000138 putative substrate binding site 2 [chemical binding]; other site 930171000139 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171000140 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171000141 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 930171000142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000143 putative PBP binding loops; other site 930171000144 dimer interface [polypeptide binding]; other site 930171000145 ABC-ATPase subunit interface; other site 930171000146 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171000147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000148 dimer interface [polypeptide binding]; other site 930171000149 conserved gate region; other site 930171000150 putative PBP binding loops; other site 930171000151 ABC-ATPase subunit interface; other site 930171000152 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 930171000153 beta-galactosidase; Region: BGL; TIGR03356 930171000154 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171000155 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171000156 DNA binding site [nucleotide binding] 930171000157 domain linker motif; other site 930171000158 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 930171000159 putative dimerization interface [polypeptide binding]; other site 930171000160 putative ligand binding site [chemical binding]; other site 930171000161 ribosome small subunit-dependent GTPase A; Region: TIGR00157 930171000162 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 930171000163 GTPase/Zn-binding domain interface [polypeptide binding]; other site 930171000164 GTP/Mg2+ binding site [chemical binding]; other site 930171000165 G4 box; other site 930171000166 G5 box; other site 930171000167 G1 box; other site 930171000168 Switch I region; other site 930171000169 G2 box; other site 930171000170 G3 box; other site 930171000171 Switch II region; other site 930171000172 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 930171000173 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 930171000174 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930171000175 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930171000176 metal binding site [ion binding]; metal-binding site 930171000177 active site 930171000178 I-site; other site 930171000179 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 930171000180 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 930171000181 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930171000182 E3 interaction surface; other site 930171000183 lipoyl attachment site [posttranslational modification]; other site 930171000184 e3 binding domain; Region: E3_binding; pfam02817 930171000185 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930171000186 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 930171000187 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 930171000188 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 930171000189 alpha subunit interface [polypeptide binding]; other site 930171000190 TPP binding site [chemical binding]; other site 930171000191 heterodimer interface [polypeptide binding]; other site 930171000192 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930171000193 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 930171000194 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 930171000195 tetramer interface [polypeptide binding]; other site 930171000196 TPP-binding site [chemical binding]; other site 930171000197 heterodimer interface [polypeptide binding]; other site 930171000198 phosphorylation loop region [posttranslational modification] 930171000199 acetyl-CoA synthetase; Provisional; Region: PRK04319 930171000200 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 930171000201 active site 930171000202 acyl-activating enzyme (AAE) consensus motif; other site 930171000203 putative CoA binding site [chemical binding]; other site 930171000204 AMP binding site [chemical binding]; other site 930171000205 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930171000206 active site 930171000207 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 930171000208 Erythromycin esterase; Region: Erythro_esteras; pfam05139 930171000209 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 930171000210 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 930171000211 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 930171000212 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 930171000213 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171000214 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171000215 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 930171000216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 930171000217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 930171000218 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 930171000219 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 930171000220 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 930171000221 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 930171000222 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 930171000223 Putative cyclase; Region: Cyclase; pfam04199 930171000224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171000225 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 930171000226 NAD(P) binding site [chemical binding]; other site 930171000227 active site 930171000228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171000229 metabolite-proton symporter; Region: 2A0106; TIGR00883 930171000230 putative substrate translocation pore; other site 930171000231 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930171000232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171000233 DNA-binding site [nucleotide binding]; DNA binding site 930171000234 FCD domain; Region: FCD; pfam07729 930171000235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171000236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171000237 MOSC domain; Region: MOSC; pfam03473 930171000238 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 930171000239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171000240 Walker A/P-loop; other site 930171000241 ATP binding site [chemical binding]; other site 930171000242 Q-loop/lid; other site 930171000243 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930171000244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171000245 Walker A/P-loop; other site 930171000246 ATP binding site [chemical binding]; other site 930171000247 Q-loop/lid; other site 930171000248 ABC transporter signature motif; other site 930171000249 Walker B; other site 930171000250 D-loop; other site 930171000251 H-loop/switch region; other site 930171000252 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 930171000253 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171000254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930171000255 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930171000256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930171000257 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171000258 Coenzyme A binding pocket [chemical binding]; other site 930171000259 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930171000260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171000261 DNA-binding site [nucleotide binding]; DNA binding site 930171000262 FCD domain; Region: FCD; pfam07729 930171000263 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 930171000264 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930171000265 ABC transporter signature motif; other site 930171000266 Walker B; other site 930171000267 D-loop; other site 930171000268 H-loop/switch region; other site 930171000269 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930171000270 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 930171000271 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930171000272 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930171000273 TM-ABC transporter signature motif; other site 930171000274 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930171000275 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930171000276 TM-ABC transporter signature motif; other site 930171000277 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 930171000278 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 930171000279 putative ligand binding site [chemical binding]; other site 930171000280 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 930171000281 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930171000282 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 930171000283 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 930171000284 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 930171000285 NAD(P) binding site [chemical binding]; other site 930171000286 catalytic residues [active] 930171000287 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171000288 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171000289 Protein of unknown function (DUF993); Region: DUF993; pfam06187 930171000290 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 930171000291 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 930171000292 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 930171000293 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 930171000294 active site 930171000295 catalytic residues [active] 930171000296 DNA binding site [nucleotide binding] 930171000297 Int/Topo IB signature motif; other site 930171000298 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 930171000299 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930171000300 META domain; Region: META; pfam03724 930171000301 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 930171000302 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 930171000303 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 930171000304 catalytic residues [active] 930171000305 catalytic nucleophile [active] 930171000306 Presynaptic Site I dimer interface [polypeptide binding]; other site 930171000307 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 930171000308 Synaptic Flat tetramer interface [polypeptide binding]; other site 930171000309 Synaptic Site I dimer interface [polypeptide binding]; other site 930171000310 DNA binding site [nucleotide binding] 930171000311 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 930171000312 DNA-binding interface [nucleotide binding]; DNA binding site 930171000313 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 930171000314 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 930171000315 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 930171000316 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 930171000317 DctM-like transporters; Region: DctM; pfam06808 930171000318 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 930171000319 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 930171000320 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 930171000321 metal binding site [ion binding]; metal-binding site 930171000322 substrate binding pocket [chemical binding]; other site 930171000323 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 930171000324 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 930171000325 dimer interface [polypeptide binding]; other site 930171000326 NADP binding site [chemical binding]; other site 930171000327 catalytic residues [active] 930171000328 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 930171000329 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930171000330 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930171000331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171000332 DNA-binding site [nucleotide binding]; DNA binding site 930171000333 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 930171000334 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 930171000335 classical (c) SDRs; Region: SDR_c; cd05233 930171000336 NAD(P) binding site [chemical binding]; other site 930171000337 active site 930171000338 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 930171000339 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930171000340 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171000341 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171000342 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171000343 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 930171000344 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930171000345 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 930171000346 Metal-binding active site; metal-binding site 930171000347 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 930171000348 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171000349 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171000350 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171000351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000352 dimer interface [polypeptide binding]; other site 930171000353 conserved gate region; other site 930171000354 putative PBP binding loops; other site 930171000355 ABC-ATPase subunit interface; other site 930171000356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000357 dimer interface [polypeptide binding]; other site 930171000358 conserved gate region; other site 930171000359 putative PBP binding loops; other site 930171000360 ABC-ATPase subunit interface; other site 930171000361 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171000362 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171000363 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171000364 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171000365 DNA binding site [nucleotide binding] 930171000366 domain linker motif; other site 930171000367 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 930171000368 putative ligand binding site [chemical binding]; other site 930171000369 putative dimerization interface [polypeptide binding]; other site 930171000370 galactonate dehydratase; Provisional; Region: PRK14017 930171000371 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 930171000372 active site pocket [active] 930171000373 Hemerythrin-like domain; Region: Hr-like; cd12108 930171000374 Fe binding site [ion binding]; other site 930171000375 Helix-turn-helix domain; Region: HTH_31; pfam13560 930171000376 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 930171000377 phosphoenolpyruvate synthase; Validated; Region: PRK06464 930171000378 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 930171000379 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930171000380 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 930171000381 PEP synthetase regulatory protein; Provisional; Region: PRK05339 930171000382 MarR family; Region: MarR_2; pfam12802 930171000383 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930171000384 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930171000385 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 930171000386 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 930171000387 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 930171000388 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 930171000389 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 930171000390 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171000391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000392 dimer interface [polypeptide binding]; other site 930171000393 conserved gate region; other site 930171000394 putative PBP binding loops; other site 930171000395 ABC-ATPase subunit interface; other site 930171000396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000397 dimer interface [polypeptide binding]; other site 930171000398 conserved gate region; other site 930171000399 putative PBP binding loops; other site 930171000400 ABC-ATPase subunit interface; other site 930171000401 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171000402 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171000403 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 930171000404 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 930171000405 synthetase active site [active] 930171000406 NTP binding site [chemical binding]; other site 930171000407 metal binding site [ion binding]; metal-binding site 930171000408 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171000409 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171000410 DNA binding site [nucleotide binding] 930171000411 domain linker motif; other site 930171000412 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171000413 dimerization interface [polypeptide binding]; other site 930171000414 ligand binding site [chemical binding]; other site 930171000415 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 930171000416 EamA-like transporter family; Region: EamA; pfam00892 930171000417 B3/4 domain; Region: B3_4; pfam03483 930171000418 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930171000419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171000420 non-specific DNA binding site [nucleotide binding]; other site 930171000421 salt bridge; other site 930171000422 sequence-specific DNA binding site [nucleotide binding]; other site 930171000423 Cupin domain; Region: Cupin_2; pfam07883 930171000424 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 930171000425 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 930171000426 NAD(P) binding site [chemical binding]; other site 930171000427 catalytic residues [active] 930171000428 GYD domain; Region: GYD; pfam08734 930171000429 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171000430 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930171000431 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 930171000432 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930171000433 putative substrate binding site [chemical binding]; other site 930171000434 putative ATP binding site [chemical binding]; other site 930171000435 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 930171000436 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930171000437 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930171000438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171000439 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 930171000440 dimerization interface [polypeptide binding]; other site 930171000441 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171000442 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171000443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000444 dimer interface [polypeptide binding]; other site 930171000445 conserved gate region; other site 930171000446 putative PBP binding loops; other site 930171000447 ABC-ATPase subunit interface; other site 930171000448 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171000449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000450 dimer interface [polypeptide binding]; other site 930171000451 conserved gate region; other site 930171000452 putative PBP binding loops; other site 930171000453 ABC-ATPase subunit interface; other site 930171000454 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 930171000455 pyranose oxidase; Region: pyranose_ox; TIGR02462 930171000456 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 930171000457 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 930171000458 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930171000459 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 930171000460 SnoaL-like domain; Region: SnoaL_4; pfam13577 930171000461 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171000462 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171000463 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171000464 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930171000465 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 930171000466 Metal-binding active site; metal-binding site 930171000467 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 930171000468 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 930171000469 Helix-turn-helix domain; Region: HTH_38; pfam13936 930171000470 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171000471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171000472 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171000473 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 930171000474 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930171000475 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930171000476 nucleotide binding site [chemical binding]; other site 930171000477 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171000478 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171000479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171000480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171000481 pyranose oxidase; Region: pyranose_ox; TIGR02462 930171000482 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 930171000483 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 930171000484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171000485 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 930171000486 substrate binding pocket [chemical binding]; other site 930171000487 dimerization interface [polypeptide binding]; other site 930171000488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 930171000489 classical (c) SDRs; Region: SDR_c; cd05233 930171000490 NAD(P) binding site [chemical binding]; other site 930171000491 active site 930171000492 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 930171000493 classical (c) SDRs; Region: SDR_c; cd05233 930171000494 NAD(P) binding site [chemical binding]; other site 930171000495 active site 930171000496 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930171000497 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 930171000498 Amidohydrolase; Region: Amidohydro_2; pfam04909 930171000499 hypothetical protein; Provisional; Region: PRK06847 930171000500 hypothetical protein; Provisional; Region: PRK07236 930171000501 Putative cyclase; Region: Cyclase; pfam04199 930171000502 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 930171000503 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930171000504 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 930171000505 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 930171000506 active site 930171000507 metal binding site [ion binding]; metal-binding site 930171000508 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 930171000509 active site 930171000510 metal binding site [ion binding]; metal-binding site 930171000511 NMT1-like family; Region: NMT1_2; pfam13379 930171000512 NMT1/THI5 like; Region: NMT1; pfam09084 930171000513 substrate binding pocket [chemical binding]; other site 930171000514 membrane-bound complex binding site; other site 930171000515 hinge residues; other site 930171000516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171000517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171000518 choline dehydrogenase; Validated; Region: PRK02106 930171000519 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 930171000520 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 930171000521 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930171000522 NAD(P) binding site [chemical binding]; other site 930171000523 catalytic residues [active] 930171000524 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 930171000525 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 930171000526 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 930171000527 active site 930171000528 DNA binding site [nucleotide binding] 930171000529 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 930171000530 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 930171000531 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 930171000532 Catalytic site [active] 930171000533 Nucleoside Triphosphate Pyrophosphohydrolase EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u6; cd11543 930171000534 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 930171000535 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 930171000536 active site 930171000537 catalytic site [active] 930171000538 Zn binding site [ion binding]; other site 930171000539 tetramer interface [polypeptide binding]; other site 930171000540 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 930171000541 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 930171000542 Na binding site [ion binding]; other site 930171000543 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 930171000544 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930171000545 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 930171000546 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 930171000547 putative active site [active] 930171000548 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 930171000549 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 930171000550 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 930171000551 putative active site [active] 930171000552 putative substrate binding site [chemical binding]; other site 930171000553 putative cosubstrate binding site; other site 930171000554 catalytic site [active] 930171000555 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 930171000556 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 930171000557 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 930171000558 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 930171000559 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 930171000560 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 930171000561 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 930171000562 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 930171000563 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 930171000564 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 930171000565 hydroxyglutarate oxidase; Provisional; Region: PRK11728 930171000566 hydroxyglutarate oxidase; Provisional; Region: PRK11728 930171000567 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 930171000568 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 930171000569 dimer interface [polypeptide binding]; other site 930171000570 active site 930171000571 glycine-pyridoxal phosphate binding site [chemical binding]; other site 930171000572 folate binding site [chemical binding]; other site 930171000573 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930171000574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171000575 DNA-binding site [nucleotide binding]; DNA binding site 930171000576 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 930171000577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 930171000578 putative substrate translocation pore; other site 930171000579 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 930171000580 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930171000581 putative active site [active] 930171000582 putative metal binding site [ion binding]; other site 930171000583 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 930171000584 active site 930171000585 dimer interface [polypeptide binding]; other site 930171000586 magnesium binding site [ion binding]; other site 930171000587 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 930171000588 tetramer interface [polypeptide binding]; other site 930171000589 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930171000590 active site 930171000591 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171000592 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171000593 DNA binding residues [nucleotide binding] 930171000594 dimerization interface [polypeptide binding]; other site 930171000595 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 930171000596 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171000597 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171000598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930171000599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171000600 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 930171000601 putative dimerization interface [polypeptide binding]; other site 930171000602 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 930171000603 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 930171000604 [2Fe-2S] cluster binding site [ion binding]; other site 930171000605 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 930171000606 putative alpha subunit interface [polypeptide binding]; other site 930171000607 putative active site [active] 930171000608 putative substrate binding site [chemical binding]; other site 930171000609 Fe binding site [ion binding]; other site 930171000610 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 930171000611 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 930171000612 FAD binding pocket [chemical binding]; other site 930171000613 FAD binding motif [chemical binding]; other site 930171000614 phosphate binding motif [ion binding]; other site 930171000615 beta-alpha-beta structure motif; other site 930171000616 NAD binding pocket [chemical binding]; other site 930171000617 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 930171000618 catalytic loop [active] 930171000619 iron binding site [ion binding]; other site 930171000620 BCCT family transporter; Region: BCCT; pfam02028 930171000621 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 930171000622 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 930171000623 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 930171000624 putative active site [active] 930171000625 putative substrate binding site [chemical binding]; other site 930171000626 putative cosubstrate binding site; other site 930171000627 catalytic site [active] 930171000628 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930171000629 hydroxyglutarate oxidase; Provisional; Region: PRK11728 930171000630 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 930171000631 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 930171000632 Domain of unknown function (DUF222); Region: DUF222; pfam02720 930171000633 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171000634 active site 930171000635 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 930171000636 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 930171000637 putative molybdopterin cofactor binding site [chemical binding]; other site 930171000638 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 930171000639 putative molybdopterin cofactor binding site; other site 930171000640 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930171000641 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 930171000642 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 930171000643 NAD binding site [chemical binding]; other site 930171000644 catalytic Zn binding site [ion binding]; other site 930171000645 substrate binding site [chemical binding]; other site 930171000646 structural Zn binding site [ion binding]; other site 930171000647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171000648 metabolite-proton symporter; Region: 2A0106; TIGR00883 930171000649 putative substrate translocation pore; other site 930171000650 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 930171000651 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 930171000652 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 930171000653 active site 930171000654 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171000655 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 930171000656 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171000657 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 930171000658 dimerization interface [polypeptide binding]; other site 930171000659 active site 930171000660 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930171000661 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 930171000662 active site 930171000663 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171000664 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930171000665 active site 930171000666 motif I; other site 930171000667 motif II; other site 930171000668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171000669 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 930171000670 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 930171000671 putative active site [active] 930171000672 catalytic site [active] 930171000673 putative metal binding site [ion binding]; other site 930171000674 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930171000675 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930171000676 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930171000677 metal binding site [ion binding]; metal-binding site 930171000678 active site 930171000679 I-site; other site 930171000680 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930171000681 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 930171000682 GAF domain; Region: GAF_3; pfam13492 930171000683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930171000684 dimer interface [polypeptide binding]; other site 930171000685 phosphorylation site [posttranslational modification] 930171000686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171000687 ATP binding site [chemical binding]; other site 930171000688 Mg2+ binding site [ion binding]; other site 930171000689 G-X-G motif; other site 930171000690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 930171000691 oxidoreductase; Provisional; Region: PRK12743 930171000692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171000693 NAD(P) binding site [chemical binding]; other site 930171000694 active site 930171000695 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 930171000696 short chain dehydrogenase; Provisional; Region: PRK06701 930171000697 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 930171000698 NAD binding site [chemical binding]; other site 930171000699 metal binding site [ion binding]; metal-binding site 930171000700 active site 930171000701 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930171000702 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930171000703 active site 930171000704 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 930171000705 GAF domain; Region: GAF; pfam01590 930171000706 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 930171000707 active site 930171000708 catalytic triad [active] 930171000709 oxyanion hole [active] 930171000710 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 930171000711 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 930171000712 putative FMN binding site [chemical binding]; other site 930171000713 phosphoglucomutase; Validated; Region: PRK07564 930171000714 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 930171000715 active site 930171000716 substrate binding site [chemical binding]; other site 930171000717 metal binding site [ion binding]; metal-binding site 930171000718 Nuclease-related domain; Region: NERD; pfam08378 930171000719 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 930171000720 FAD binding domain; Region: FAD_binding_4; pfam01565 930171000721 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 930171000722 Berberine and berberine like; Region: BBE; pfam08031 930171000723 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 930171000724 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 930171000725 Amidase; Region: Amidase; cl11426 930171000726 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930171000727 active site residue [active] 930171000728 prephenate dehydratase; Provisional; Region: PRK11898 930171000729 Prephenate dehydratase; Region: PDT; pfam00800 930171000730 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 930171000731 putative L-Phe binding site [chemical binding]; other site 930171000732 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 930171000733 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 930171000734 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 930171000735 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 930171000736 seryl-tRNA synthetase; Provisional; Region: PRK05431 930171000737 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 930171000738 dimer interface [polypeptide binding]; other site 930171000739 active site 930171000740 motif 1; other site 930171000741 motif 2; other site 930171000742 motif 3; other site 930171000743 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 930171000744 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 930171000745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171000746 active site 930171000747 motif I; other site 930171000748 motif II; other site 930171000749 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930171000750 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930171000751 catalytic core [active] 930171000752 putative phosphoketolase; Provisional; Region: PRK05261 930171000753 XFP N-terminal domain; Region: XFP_N; pfam09364 930171000754 XFP C-terminal domain; Region: XFP_C; pfam09363 930171000755 Protein of unknown function (DUF429); Region: DUF429; pfam04250 930171000756 Carboxylesterase family; Region: COesterase; pfam00135 930171000757 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930171000758 substrate binding pocket [chemical binding]; other site 930171000759 catalytic triad [active] 930171000760 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 930171000761 dimer interface [polypeptide binding]; other site 930171000762 substrate binding site [chemical binding]; other site 930171000763 metal binding sites [ion binding]; metal-binding site 930171000764 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 930171000765 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 930171000766 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 930171000767 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 930171000768 putative hydrolase; Region: TIGR03624 930171000769 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 930171000770 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 930171000771 Ligand Binding Site [chemical binding]; other site 930171000772 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930171000773 active site 930171000774 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171000775 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171000776 DNA binding site [nucleotide binding] 930171000777 domain linker motif; other site 930171000778 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 930171000779 putative dimerization interface [polypeptide binding]; other site 930171000780 putative ligand binding site [chemical binding]; other site 930171000781 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 930171000782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171000783 Walker A motif; other site 930171000784 ATP binding site [chemical binding]; other site 930171000785 Walker B motif; other site 930171000786 arginine finger; other site 930171000787 Peptidase family M41; Region: Peptidase_M41; pfam01434 930171000788 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 930171000789 homodecamer interface [polypeptide binding]; other site 930171000790 GTP cyclohydrolase I; Provisional; Region: PLN03044 930171000791 active site 930171000792 putative catalytic site residues [active] 930171000793 zinc binding site [ion binding]; other site 930171000794 GTP-CH-I/GFRP interaction surface; other site 930171000795 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 930171000796 dihydropteroate synthase; Region: DHPS; TIGR01496 930171000797 substrate binding pocket [chemical binding]; other site 930171000798 dimer interface [polypeptide binding]; other site 930171000799 inhibitor binding site; inhibition site 930171000800 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 930171000801 active site 930171000802 homooctamer interface [polypeptide binding]; other site 930171000803 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 930171000804 catalytic center binding site [active] 930171000805 ATP binding site [chemical binding]; other site 930171000806 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 930171000807 Bacterial PH domain; Region: DUF304; cl01348 930171000808 Bacterial PH domain; Region: DUF304; pfam03703 930171000809 Bacterial PH domain; Region: DUF304; pfam03703 930171000810 Bacterial PH domain; Region: DUF304; pfam03703 930171000811 Rossmann-like domain; Region: Rossmann-like; pfam10727 930171000812 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 930171000813 pantoate--beta-alanine ligase; Region: panC; TIGR00018 930171000814 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 930171000815 active site 930171000816 nucleotide binding site [chemical binding]; other site 930171000817 HIGH motif; other site 930171000818 KMSKS motif; other site 930171000819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171000820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171000821 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171000822 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171000823 DNA binding site [nucleotide binding] 930171000824 domain linker motif; other site 930171000825 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171000826 dimerization interface [polypeptide binding]; other site 930171000827 ligand binding site [chemical binding]; other site 930171000828 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 930171000829 active site 930171000830 catalytic site [active] 930171000831 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171000832 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 930171000833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000834 dimer interface [polypeptide binding]; other site 930171000835 conserved gate region; other site 930171000836 ABC-ATPase subunit interface; other site 930171000837 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171000838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000839 dimer interface [polypeptide binding]; other site 930171000840 conserved gate region; other site 930171000841 putative PBP binding loops; other site 930171000842 ABC-ATPase subunit interface; other site 930171000843 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 930171000844 intracellular protease, PfpI family; Region: PfpI; TIGR01382 930171000845 proposed catalytic triad [active] 930171000846 conserved cys residue [active] 930171000847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171000848 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 930171000849 putative substrate translocation pore; other site 930171000850 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171000851 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171000852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171000853 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 930171000854 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 930171000855 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 930171000856 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 930171000857 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 930171000858 urea carboxylase; Region: urea_carbox; TIGR02712 930171000859 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930171000860 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930171000861 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 930171000862 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 930171000863 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 930171000864 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930171000865 carboxyltransferase (CT) interaction site; other site 930171000866 biotinylation site [posttranslational modification]; other site 930171000867 allophanate hydrolase; Provisional; Region: PRK08186 930171000868 Amidase; Region: Amidase; cl11426 930171000869 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930171000870 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 930171000871 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 930171000872 dimer interface [polypeptide binding]; other site 930171000873 putative anticodon binding site; other site 930171000874 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 930171000875 motif 1; other site 930171000876 dimer interface [polypeptide binding]; other site 930171000877 active site 930171000878 motif 2; other site 930171000879 motif 3; other site 930171000880 Lsr2; Region: Lsr2; pfam11774 930171000881 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 930171000882 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 930171000883 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930171000884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171000885 Coenzyme A binding pocket [chemical binding]; other site 930171000886 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 930171000887 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 930171000888 DAK2 domain; Region: Dak2; cl03685 930171000889 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 930171000890 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 930171000891 dimerization domain swap beta strand [polypeptide binding]; other site 930171000892 regulatory protein interface [polypeptide binding]; other site 930171000893 active site 930171000894 regulatory phosphorylation site [posttranslational modification]; other site 930171000895 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 930171000896 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 930171000897 minor groove reading motif; other site 930171000898 helix-hairpin-helix signature motif; other site 930171000899 active site 930171000900 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 930171000901 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 930171000902 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 930171000903 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 930171000904 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 930171000905 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 930171000906 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 930171000907 G1 box; other site 930171000908 putative GEF interaction site [polypeptide binding]; other site 930171000909 GTP/Mg2+ binding site [chemical binding]; other site 930171000910 Switch I region; other site 930171000911 G2 box; other site 930171000912 G3 box; other site 930171000913 Switch II region; other site 930171000914 G4 box; other site 930171000915 G5 box; other site 930171000916 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 930171000917 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 930171000918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171000919 putative substrate translocation pore; other site 930171000920 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 930171000921 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 930171000922 active site 930171000923 tetramer interface [polypeptide binding]; other site 930171000924 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 930171000925 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 930171000926 dimer interface [polypeptide binding]; other site 930171000927 NADP binding site [chemical binding]; other site 930171000928 catalytic residues [active] 930171000929 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 930171000930 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 930171000931 putative active site [active] 930171000932 catalytic residue [active] 930171000933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171000934 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 930171000935 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 930171000936 putative dimerization interface [polypeptide binding]; other site 930171000937 putative substrate binding pocket [chemical binding]; other site 930171000938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 930171000939 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 930171000940 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 930171000941 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171000942 Ligand Binding Site [chemical binding]; other site 930171000943 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 930171000944 nudix motif; other site 930171000945 DNA repair protein RadA; Provisional; Region: PRK11823 930171000946 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 930171000947 Walker A motif; other site 930171000948 ATP binding site [chemical binding]; other site 930171000949 Walker B motif; other site 930171000950 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 930171000951 Predicted membrane protein [Function unknown]; Region: COG4129 930171000952 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 930171000953 PBP superfamily domain; Region: PBP_like_2; cl17296 930171000954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000955 dimer interface [polypeptide binding]; other site 930171000956 conserved gate region; other site 930171000957 putative PBP binding loops; other site 930171000958 ABC-ATPase subunit interface; other site 930171000959 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 930171000960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171000961 dimer interface [polypeptide binding]; other site 930171000962 conserved gate region; other site 930171000963 putative PBP binding loops; other site 930171000964 ABC-ATPase subunit interface; other site 930171000965 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 930171000966 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 930171000967 Walker A/P-loop; other site 930171000968 ATP binding site [chemical binding]; other site 930171000969 Q-loop/lid; other site 930171000970 ABC transporter signature motif; other site 930171000971 Walker B; other site 930171000972 D-loop; other site 930171000973 H-loop/switch region; other site 930171000974 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 930171000975 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 930171000976 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171000977 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171000978 DNA binding site [nucleotide binding] 930171000979 domain linker motif; other site 930171000980 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 930171000981 ligand binding site [chemical binding]; other site 930171000982 dimerization interface (open form) [polypeptide binding]; other site 930171000983 dimerization interface (closed form) [polypeptide binding]; other site 930171000984 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 930171000985 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 930171000986 active site 930171000987 catalytic site [active] 930171000988 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 930171000989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930171000990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930171000991 DNA binding residues [nucleotide binding] 930171000992 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 930171000993 ribulokinase; Provisional; Region: PRK04123 930171000994 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 930171000995 N- and C-terminal domain interface [polypeptide binding]; other site 930171000996 active site 930171000997 MgATP binding site [chemical binding]; other site 930171000998 catalytic site [active] 930171000999 metal binding site [ion binding]; metal-binding site 930171001000 carbohydrate binding site [chemical binding]; other site 930171001001 homodimer interface [polypeptide binding]; other site 930171001002 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 930171001003 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 930171001004 intersubunit interface [polypeptide binding]; other site 930171001005 active site 930171001006 Zn2+ binding site [ion binding]; other site 930171001007 L-arabinose isomerase; Provisional; Region: PRK02929 930171001008 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 930171001009 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930171001010 trimer interface [polypeptide binding]; other site 930171001011 substrate binding site [chemical binding]; other site 930171001012 Mn binding site [ion binding]; other site 930171001013 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171001014 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 930171001015 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 930171001016 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 930171001017 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171001018 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171001019 DNA binding site [nucleotide binding] 930171001020 domain linker motif; other site 930171001021 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171001022 dimerization interface [polypeptide binding]; other site 930171001023 ligand binding site [chemical binding]; other site 930171001024 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 930171001025 Isochorismatase family; Region: Isochorismatase; pfam00857 930171001026 catalytic triad [active] 930171001027 conserved cis-peptide bond; other site 930171001028 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 930171001029 alpha-gamma subunit interface [polypeptide binding]; other site 930171001030 beta-gamma subunit interface [polypeptide binding]; other site 930171001031 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 930171001032 gamma-beta subunit interface [polypeptide binding]; other site 930171001033 alpha-beta subunit interface [polypeptide binding]; other site 930171001034 urease subunit alpha; Reviewed; Region: ureC; PRK13207 930171001035 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 930171001036 subunit interactions [polypeptide binding]; other site 930171001037 active site 930171001038 flap region; other site 930171001039 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 930171001040 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 930171001041 dimer interface [polypeptide binding]; other site 930171001042 catalytic residues [active] 930171001043 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 930171001044 UreF; Region: UreF; pfam01730 930171001045 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930171001046 UreD urease accessory protein; Region: UreD; cl00530 930171001047 High-affinity nickel-transport protein; Region: NicO; cl00964 930171001048 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 930171001049 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171001050 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930171001051 DNA-binding site [nucleotide binding]; DNA binding site 930171001052 FCD domain; Region: FCD; pfam07729 930171001053 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 930171001054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171001055 putative substrate translocation pore; other site 930171001056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171001057 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 930171001058 NAD(P) binding site [chemical binding]; other site 930171001059 active site 930171001060 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 930171001061 putative hydrophobic ligand binding site [chemical binding]; other site 930171001062 GAF domain; Region: GAF; pfam01590 930171001063 GAF domain; Region: GAF_2; pfam13185 930171001064 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171001065 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 930171001066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171001067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171001068 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930171001069 EamA-like transporter family; Region: EamA; pfam00892 930171001070 Protein of unknown function, DUF488; Region: DUF488; pfam04343 930171001071 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 930171001072 GAF domain; Region: GAF_2; pfam13185 930171001073 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171001074 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 930171001075 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 930171001076 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 930171001077 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 930171001078 NAD(P) binding site [chemical binding]; other site 930171001079 putative active site [active] 930171001080 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 930171001081 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 930171001082 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 930171001083 active site 930171001084 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 930171001085 active site 930171001086 catalytic site [active] 930171001087 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 930171001088 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 930171001089 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 930171001090 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 930171001091 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 930171001092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171001093 S-adenosylmethionine binding site [chemical binding]; other site 930171001094 Domain of unknown function (DUF222); Region: DUF222; pfam02720 930171001095 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171001096 active site 930171001097 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171001098 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171001099 active site 930171001100 catalytic tetrad [active] 930171001101 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 930171001102 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 930171001103 metal binding site [ion binding]; metal-binding site 930171001104 active site 930171001105 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 930171001106 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930171001107 putative NAD(P) binding site [chemical binding]; other site 930171001108 active site 930171001109 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171001110 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171001111 active site 930171001112 catalytic tetrad [active] 930171001113 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171001114 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171001115 active site 930171001116 catalytic tetrad [active] 930171001117 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930171001118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171001119 salt bridge; other site 930171001120 non-specific DNA binding site [nucleotide binding]; other site 930171001121 sequence-specific DNA binding site [nucleotide binding]; other site 930171001122 Dodecin; Region: Dodecin; pfam07311 930171001123 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930171001124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171001125 DNA-binding site [nucleotide binding]; DNA binding site 930171001126 FCD domain; Region: FCD; pfam07729 930171001127 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 930171001128 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 930171001129 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930171001130 putative transporter; Provisional; Region: PRK09821 930171001131 GntP family permease; Region: GntP_permease; pfam02447 930171001132 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 930171001133 active site 930171001134 intersubunit interface [polypeptide binding]; other site 930171001135 zinc binding site [ion binding]; other site 930171001136 Na+ binding site [ion binding]; other site 930171001137 Acyltransferase family; Region: Acyl_transf_3; pfam01757 930171001138 Predicted acetyltransferase [General function prediction only]; Region: COG2388 930171001139 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 930171001140 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 930171001141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171001142 catalytic residue [active] 930171001143 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 930171001144 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930171001145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 930171001146 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 930171001147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930171001148 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 930171001149 IucA / IucC family; Region: IucA_IucC; pfam04183 930171001150 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 930171001151 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 930171001152 classical (c) SDRs; Region: SDR_c; cd05233 930171001153 NAD(P) binding site [chemical binding]; other site 930171001154 active site 930171001155 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 930171001156 proline/glycine betaine transporter; Provisional; Region: PRK10642 930171001157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171001158 putative substrate translocation pore; other site 930171001159 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 930171001160 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 930171001161 nucleotide binding site [chemical binding]; other site 930171001162 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 930171001163 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 930171001164 active site 930171001165 DNA binding site [nucleotide binding] 930171001166 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 930171001167 DNA binding site [nucleotide binding] 930171001168 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 930171001169 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 930171001170 putative DNA binding site [nucleotide binding]; other site 930171001171 putative homodimer interface [polypeptide binding]; other site 930171001172 Methyltransferase domain; Region: Methyltransf_11; pfam08241 930171001173 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 930171001174 dimerization domain swap beta strand [polypeptide binding]; other site 930171001175 regulatory protein interface [polypeptide binding]; other site 930171001176 active site 930171001177 regulatory phosphorylation site [posttranslational modification]; other site 930171001178 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 930171001179 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930171001180 active site 930171001181 phosphorylation site [posttranslational modification] 930171001182 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 930171001183 active site 930171001184 P-loop; other site 930171001185 phosphorylation site [posttranslational modification] 930171001186 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 930171001187 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 930171001188 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 930171001189 putative substrate binding site [chemical binding]; other site 930171001190 putative ATP binding site [chemical binding]; other site 930171001191 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930171001192 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930171001193 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930171001194 putative hydrolase; Provisional; Region: PRK11460 930171001195 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 930171001196 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 930171001197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171001198 motif II; other site 930171001199 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 930171001200 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 930171001201 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 930171001202 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 930171001203 H+ Antiporter protein; Region: 2A0121; TIGR00900 930171001204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171001205 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 930171001206 putative active site [active] 930171001207 Protein of unknown function (DUF445); Region: DUF445; pfam04286 930171001208 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 930171001209 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 930171001210 active site 930171001211 catalytic site [active] 930171001212 Predicted membrane protein [Function unknown]; Region: COG4270 930171001213 AzlC protein; Region: AzlC; pfam03591 930171001214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171001215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171001216 Domain of unknown function DUF77; Region: DUF77; pfam01910 930171001217 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 930171001218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 930171001219 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 930171001220 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 930171001221 dimerization interface [polypeptide binding]; other site 930171001222 DPS ferroxidase diiron center [ion binding]; other site 930171001223 ion pore; other site 930171001224 CsbD-like; Region: CsbD; cl17424 930171001225 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 930171001226 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 930171001227 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 930171001228 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930171001229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171001230 NAD(P) binding site [chemical binding]; other site 930171001231 active site 930171001232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930171001233 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 930171001234 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930171001235 DNA binding residues [nucleotide binding] 930171001236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171001237 active site 930171001238 motif I; other site 930171001239 motif II; other site 930171001240 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 930171001241 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 930171001242 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 930171001243 putative active site [active] 930171001244 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930171001245 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 930171001246 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 930171001247 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 930171001248 putative ADP-binding pocket [chemical binding]; other site 930171001249 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 930171001250 active site 930171001251 dimer interface [polypeptide binding]; other site 930171001252 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 930171001253 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 930171001254 substrate binding site [chemical binding]; other site 930171001255 ATP binding site [chemical binding]; other site 930171001256 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 930171001257 active site 930171001258 HIGH motif; other site 930171001259 nucleotide binding site [chemical binding]; other site 930171001260 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 930171001261 classical (c) SDRs; Region: SDR_c; cd05233 930171001262 NAD(P) binding site [chemical binding]; other site 930171001263 active site 930171001264 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 930171001265 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 930171001266 NAD(P) binding site [chemical binding]; other site 930171001267 catalytic residues [active] 930171001268 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 930171001269 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 930171001270 substrate binding site [chemical binding]; other site 930171001271 ATP binding site [chemical binding]; other site 930171001272 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 930171001273 active site 930171001274 nucleotide binding site [chemical binding]; other site 930171001275 HIGH motif; other site 930171001276 KMSKS motif; other site 930171001277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 930171001278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930171001279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171001280 LysR substrate binding domain; Region: LysR_substrate; pfam03466 930171001281 dimerization interface [polypeptide binding]; other site 930171001282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171001283 metabolite-proton symporter; Region: 2A0106; TIGR00883 930171001284 putative substrate translocation pore; other site 930171001285 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 930171001286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171001287 NAD(P) binding site [chemical binding]; other site 930171001288 active site 930171001289 Predicted transcriptional regulators [Transcription]; Region: COG1733 930171001290 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 930171001291 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 930171001292 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 930171001293 NADP binding site [chemical binding]; other site 930171001294 putative proline-specific permease; Provisional; Region: proY; PRK10580 930171001295 Spore germination protein; Region: Spore_permease; cl17796 930171001296 hypothetical protein; Provisional; Region: PRK07758 930171001297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171001298 putative DNA binding site [nucleotide binding]; other site 930171001299 dimerization interface [polypeptide binding]; other site 930171001300 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171001301 putative Zn2+ binding site [ion binding]; other site 930171001302 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171001303 urocanate hydratase; Provisional; Region: PRK05414 930171001304 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 930171001305 active sites [active] 930171001306 tetramer interface [polypeptide binding]; other site 930171001307 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 930171001308 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930171001309 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171001310 Ligand Binding Site [chemical binding]; other site 930171001311 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 930171001312 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 930171001313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 930171001314 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 930171001315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930171001316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171001317 ATP binding site [chemical binding]; other site 930171001318 Mg2+ binding site [ion binding]; other site 930171001319 G-X-G motif; other site 930171001320 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 930171001321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171001322 active site 930171001323 phosphorylation site [posttranslational modification] 930171001324 intermolecular recognition site; other site 930171001325 dimerization interface [polypeptide binding]; other site 930171001326 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 930171001327 putative active site [active] 930171001328 putative metal binding site [ion binding]; other site 930171001329 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 930171001330 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930171001331 CopC domain; Region: CopC; pfam04234 930171001332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930171001333 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171001334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171001335 Ligand Binding Site [chemical binding]; other site 930171001336 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 930171001337 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930171001338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171001339 Walker A/P-loop; other site 930171001340 ATP binding site [chemical binding]; other site 930171001341 Q-loop/lid; other site 930171001342 ABC transporter signature motif; other site 930171001343 Walker B; other site 930171001344 D-loop; other site 930171001345 H-loop/switch region; other site 930171001346 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 930171001347 NlpC/P60 family; Region: NLPC_P60; pfam00877 930171001348 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 930171001349 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 930171001350 EamA-like transporter family; Region: EamA; pfam00892 930171001351 EamA-like transporter family; Region: EamA; pfam00892 930171001352 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 930171001353 Thioredoxin; Region: Thioredoxin_4; cl17273 930171001354 hypothetical protein; Provisional; Region: PRK07945 930171001355 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 930171001356 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 930171001357 active site 930171001358 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 930171001359 active site 930171001360 Asp23 family; Region: Asp23; pfam03780 930171001361 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 930171001362 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 930171001363 active site 930171001364 catalytic site [active] 930171001365 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171001366 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 930171001367 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 930171001368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171001369 dimer interface [polypeptide binding]; other site 930171001370 conserved gate region; other site 930171001371 putative PBP binding loops; other site 930171001372 ABC-ATPase subunit interface; other site 930171001373 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171001374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171001375 dimer interface [polypeptide binding]; other site 930171001376 conserved gate region; other site 930171001377 putative PBP binding loops; other site 930171001378 ABC-ATPase subunit interface; other site 930171001379 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171001380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171001381 DNA binding site [nucleotide binding] 930171001382 domain linker motif; other site 930171001383 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171001384 dimerization interface [polypeptide binding]; other site 930171001385 ligand binding site [chemical binding]; other site 930171001386 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 930171001387 active site 930171001388 metal binding site A [ion binding]; metal-binding site 930171001389 DNA binding site [nucleotide binding] 930171001390 putative catalytic site [active] 930171001391 putative phosphate binding site [ion binding]; other site 930171001392 putative AP binding site [nucleotide binding]; other site 930171001393 putative metal binding site B [ion binding]; other site 930171001394 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 930171001395 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 930171001396 tetrameric interface [polypeptide binding]; other site 930171001397 NAD binding site [chemical binding]; other site 930171001398 catalytic residues [active] 930171001399 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 930171001400 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930171001401 substrate binding site [chemical binding]; other site 930171001402 oxyanion hole (OAH) forming residues; other site 930171001403 trimer interface [polypeptide binding]; other site 930171001404 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 930171001405 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930171001406 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 930171001407 enoyl-CoA hydratase; Provisional; Region: PRK05862 930171001408 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930171001409 substrate binding site [chemical binding]; other site 930171001410 oxyanion hole (OAH) forming residues; other site 930171001411 trimer interface [polypeptide binding]; other site 930171001412 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 930171001413 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 930171001414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171001415 non-specific DNA binding site [nucleotide binding]; other site 930171001416 salt bridge; other site 930171001417 sequence-specific DNA binding site [nucleotide binding]; other site 930171001418 Cupin domain; Region: Cupin_2; pfam07883 930171001419 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930171001420 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930171001421 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930171001422 MarR family; Region: MarR; pfam01047 930171001423 acyl-coenzyme A oxidase; Region: PLN02526 930171001424 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930171001425 active site 930171001426 short chain dehydrogenase; Provisional; Region: PRK06139 930171001427 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 930171001428 putative NAD(P) binding site [chemical binding]; other site 930171001429 active site 930171001430 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 930171001431 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930171001432 DNA binding residues [nucleotide binding] 930171001433 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 930171001434 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930171001435 DNA-binding site [nucleotide binding]; DNA binding site 930171001436 RNA-binding motif; other site 930171001437 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171001438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171001439 active site 930171001440 phosphorylation site [posttranslational modification] 930171001441 intermolecular recognition site; other site 930171001442 dimerization interface [polypeptide binding]; other site 930171001443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171001444 DNA binding residues [nucleotide binding] 930171001445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930171001446 Histidine kinase; Region: HisKA_3; pfam07730 930171001447 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 930171001448 ATP binding site [chemical binding]; other site 930171001449 G-X-G motif; other site 930171001450 Domain of unknown function (DUF336); Region: DUF336; pfam03928 930171001451 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 930171001452 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 930171001453 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 930171001454 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 930171001455 active site 930171001456 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 930171001457 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 930171001458 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171001459 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 930171001460 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171001461 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 930171001462 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 930171001463 homodimer interface [polypeptide binding]; other site 930171001464 NAD binding pocket [chemical binding]; other site 930171001465 ATP binding pocket [chemical binding]; other site 930171001466 Mg binding site [ion binding]; other site 930171001467 active-site loop [active] 930171001468 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 930171001469 active site 930171001470 GAF domain; Region: GAF_2; pfam13185 930171001471 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171001472 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 930171001473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171001474 UMP phosphatase; Provisional; Region: PRK10444 930171001475 active site 930171001476 motif I; other site 930171001477 motif II; other site 930171001478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171001479 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 930171001480 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 930171001481 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 930171001482 active site 930171001483 intersubunit interface [polypeptide binding]; other site 930171001484 zinc binding site [ion binding]; other site 930171001485 Na+ binding site [ion binding]; other site 930171001486 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 930171001487 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 930171001488 putative uracil binding site [chemical binding]; other site 930171001489 putative active site [active] 930171001490 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 930171001491 putative active site [active] 930171001492 Zn binding site [ion binding]; other site 930171001493 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 930171001494 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 930171001495 GDP-binding site [chemical binding]; other site 930171001496 ACT binding site; other site 930171001497 IMP binding site; other site 930171001498 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 930171001499 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 930171001500 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930171001501 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930171001502 DNA binding residues [nucleotide binding] 930171001503 CoA binding domain; Region: CoA_binding; cl17356 930171001504 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 930171001505 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 930171001506 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 930171001507 Protein of unknown function (DUF419); Region: DUF419; pfam04237 930171001508 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 930171001509 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930171001510 Protein of unknown function (DUF503); Region: DUF503; pfam04456 930171001511 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 930171001512 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 930171001513 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 930171001514 dimerization interface [polypeptide binding]; other site 930171001515 ATP binding site [chemical binding]; other site 930171001516 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 930171001517 dimerization interface [polypeptide binding]; other site 930171001518 ATP binding site [chemical binding]; other site 930171001519 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 930171001520 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 930171001521 putative active site [active] 930171001522 catalytic triad [active] 930171001523 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 930171001524 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 930171001525 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 930171001526 active site 930171001527 catalytic residues [active] 930171001528 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 930171001529 PA/protease or protease-like domain interface [polypeptide binding]; other site 930171001530 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 930171001531 catalytic residues [active] 930171001532 Subtilisin inhibitor-like; Region: SSI; cl11594 930171001533 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930171001534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171001535 putative DNA binding site [nucleotide binding]; other site 930171001536 putative Zn2+ binding site [ion binding]; other site 930171001537 aspartate kinase; Reviewed; Region: PRK06635 930171001538 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 930171001539 putative nucleotide binding site [chemical binding]; other site 930171001540 putative catalytic residues [active] 930171001541 putative Mg ion binding site [ion binding]; other site 930171001542 putative aspartate binding site [chemical binding]; other site 930171001543 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 930171001544 putative allosteric regulatory site; other site 930171001545 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 930171001546 putative allosteric regulatory residue; other site 930171001547 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930171001548 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930171001549 Walker A/P-loop; other site 930171001550 ATP binding site [chemical binding]; other site 930171001551 Q-loop/lid; other site 930171001552 ABC transporter signature motif; other site 930171001553 Walker B; other site 930171001554 D-loop; other site 930171001555 H-loop/switch region; other site 930171001556 recombination protein RecR; Reviewed; Region: recR; PRK00076 930171001557 RecR protein; Region: RecR; pfam02132 930171001558 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 930171001559 putative active site [active] 930171001560 putative metal-binding site [ion binding]; other site 930171001561 tetramer interface [polypeptide binding]; other site 930171001562 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 930171001563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171001564 Walker A motif; other site 930171001565 ATP binding site [chemical binding]; other site 930171001566 Walker B motif; other site 930171001567 arginine finger; other site 930171001568 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 930171001569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 930171001570 potential frameshift: common BLAST hit: gi|68536441|ref|YP_251146.1| transposase for IS3514b 930171001571 Integrase core domain; Region: rve_3; pfam13683 930171001572 Winged helix-turn helix; Region: HTH_29; pfam13551 930171001573 Homeodomain-like domain; Region: HTH_32; pfam13565 930171001574 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 930171001575 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 930171001576 catalytic residues [active] 930171001577 dimer interface [polypeptide binding]; other site 930171001578 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 930171001579 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 930171001580 active site 930171001581 metal binding site [ion binding]; metal-binding site 930171001582 hexamer interface [polypeptide binding]; other site 930171001583 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 930171001584 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 930171001585 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 930171001586 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 930171001587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171001588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171001589 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 930171001590 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 930171001591 catalytic residues [active] 930171001592 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930171001593 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 930171001594 putative ADP-binding pocket [chemical binding]; other site 930171001595 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 930171001596 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 930171001597 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 930171001598 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930171001599 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930171001600 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 930171001601 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171001602 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171001603 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171001604 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171001605 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171001606 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 930171001607 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 930171001608 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930171001609 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930171001610 nucleotide binding site [chemical binding]; other site 930171001611 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 930171001612 dimerization interface [polypeptide binding]; other site 930171001613 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 930171001614 NAD binding site [chemical binding]; other site 930171001615 ligand binding site [chemical binding]; other site 930171001616 catalytic site [active] 930171001617 cyanate transporter; Region: CynX; TIGR00896 930171001618 malate synthase A; Region: malate_syn_A; TIGR01344 930171001619 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 930171001620 active site 930171001621 isocitrate lyase; Provisional; Region: PRK15063 930171001622 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 930171001623 tetramer interface [polypeptide binding]; other site 930171001624 active site 930171001625 Mg2+/Mn2+ binding site [ion binding]; other site 930171001626 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930171001627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171001628 non-specific DNA binding site [nucleotide binding]; other site 930171001629 salt bridge; other site 930171001630 sequence-specific DNA binding site [nucleotide binding]; other site 930171001631 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 930171001632 Domain of unknown function (DUF955); Region: DUF955; pfam06114 930171001633 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 930171001634 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 930171001635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930171001636 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 930171001637 dimer interface [polypeptide binding]; other site 930171001638 phosphorylation site [posttranslational modification] 930171001639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171001640 ATP binding site [chemical binding]; other site 930171001641 Mg2+ binding site [ion binding]; other site 930171001642 G-X-G motif; other site 930171001643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930171001644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171001645 active site 930171001646 phosphorylation site [posttranslational modification] 930171001647 intermolecular recognition site; other site 930171001648 dimerization interface [polypeptide binding]; other site 930171001649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930171001650 DNA binding site [nucleotide binding] 930171001651 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 930171001652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171001653 putative substrate translocation pore; other site 930171001654 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 930171001655 reactive center loop; other site 930171001656 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 930171001657 dimer interface [polypeptide binding]; other site 930171001658 substrate binding site [chemical binding]; other site 930171001659 ATP binding site [chemical binding]; other site 930171001660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171001661 TIGR01777 family protein; Region: yfcH 930171001662 NAD(P) binding site [chemical binding]; other site 930171001663 active site 930171001664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171001665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171001666 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 930171001667 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 930171001668 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 930171001669 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 930171001670 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 930171001671 hydrophobic ligand binding site; other site 930171001672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 930171001673 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 930171001674 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 930171001675 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 930171001676 substrate binding [chemical binding]; other site 930171001677 active site 930171001678 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 930171001679 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 930171001680 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 930171001681 Walker A/P-loop; other site 930171001682 ATP binding site [chemical binding]; other site 930171001683 Q-loop/lid; other site 930171001684 ABC transporter signature motif; other site 930171001685 Walker B; other site 930171001686 D-loop; other site 930171001687 H-loop/switch region; other site 930171001688 TOBE domain; Region: TOBE_2; pfam08402 930171001689 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 930171001690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171001691 dimer interface [polypeptide binding]; other site 930171001692 conserved gate region; other site 930171001693 putative PBP binding loops; other site 930171001694 ABC-ATPase subunit interface; other site 930171001695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171001696 dimer interface [polypeptide binding]; other site 930171001697 conserved gate region; other site 930171001698 putative PBP binding loops; other site 930171001699 ABC-ATPase subunit interface; other site 930171001700 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 930171001701 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 930171001702 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 930171001703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171001704 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 930171001705 NAD(P) binding site [chemical binding]; other site 930171001706 active site 930171001707 acyl-coenzyme A oxidase; Region: PLN02526 930171001708 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930171001709 active site 930171001710 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 930171001711 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 930171001712 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 930171001713 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 930171001714 Helix-turn-helix domain; Region: HTH_28; pfam13518 930171001715 HTH-like domain; Region: HTH_21; pfam13276 930171001716 Integrase core domain; Region: rve; pfam00665 930171001717 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171001718 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171001719 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171001720 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171001721 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171001722 Integrase core domain; Region: rve_2; pfam13333 930171001723 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930171001724 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 930171001725 Bacterial transcriptional activator domain; Region: BTAD; smart01043 930171001726 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 930171001727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171001728 Walker A motif; other site 930171001729 ATP binding site [chemical binding]; other site 930171001730 Walker B motif; other site 930171001731 potential frameshift: common BLAST hit: gi|239917719|ref|YP_002957277.1| transposase 930171001732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 930171001733 Integrase core domain; Region: rve; pfam00665 930171001734 AAA domain; Region: AAA_31; pfam13614 930171001735 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 930171001736 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 930171001737 probable active site [active] 930171001738 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171001739 putative DNA binding site [nucleotide binding]; other site 930171001740 putative Zn2+ binding site [ion binding]; other site 930171001741 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 930171001742 hydrophobic ligand binding site; other site 930171001743 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 930171001744 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 930171001745 putative DNA binding site [nucleotide binding]; other site 930171001746 catalytic residue [active] 930171001747 putative H2TH interface [polypeptide binding]; other site 930171001748 putative catalytic residues [active] 930171001749 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 930171001750 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171001751 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 930171001752 ATP binding site [chemical binding]; other site 930171001753 putative Mg++ binding site [ion binding]; other site 930171001754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171001755 nucleotide binding region [chemical binding]; other site 930171001756 ATP-binding site [chemical binding]; other site 930171001757 DEAD/H associated; Region: DEAD_assoc; pfam08494 930171001758 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930171001759 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 930171001760 iron-sulfur cluster [ion binding]; other site 930171001761 [2Fe-2S] cluster binding site [ion binding]; other site 930171001762 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 930171001763 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 930171001764 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 930171001765 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 930171001766 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 930171001767 hypothetical protein; Provisional; Region: PRK05463 930171001768 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930171001769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171001770 DNA-binding site [nucleotide binding]; DNA binding site 930171001771 FCD domain; Region: FCD; pfam07729 930171001772 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 930171001773 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930171001774 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 930171001775 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 930171001776 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930171001777 carboxyltransferase (CT) interaction site; other site 930171001778 biotinylation site [posttranslational modification]; other site 930171001779 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 930171001780 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 930171001781 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 930171001782 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 930171001783 putative active site [active] 930171001784 Glutaminase; Region: Glutaminase; cl00907 930171001785 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 930171001786 Glutaminase; Region: Glutaminase; cl00907 930171001787 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930171001788 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171001789 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171001790 DNA binding site [nucleotide binding] 930171001791 domain linker motif; other site 930171001792 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171001793 ligand binding site [chemical binding]; other site 930171001794 dimerization interface [polypeptide binding]; other site 930171001795 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 930171001796 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171001797 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171001798 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171001799 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 930171001800 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 930171001801 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930171001802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171001803 dimer interface [polypeptide binding]; other site 930171001804 conserved gate region; other site 930171001805 putative PBP binding loops; other site 930171001806 ABC-ATPase subunit interface; other site 930171001807 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930171001808 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 930171001809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171001810 dimer interface [polypeptide binding]; other site 930171001811 conserved gate region; other site 930171001812 putative PBP binding loops; other site 930171001813 ABC-ATPase subunit interface; other site 930171001814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171001815 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 930171001816 Walker A/P-loop; other site 930171001817 ATP binding site [chemical binding]; other site 930171001818 Q-loop/lid; other site 930171001819 ABC transporter signature motif; other site 930171001820 Walker B; other site 930171001821 D-loop; other site 930171001822 H-loop/switch region; other site 930171001823 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171001824 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 930171001825 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171001826 Walker A/P-loop; other site 930171001827 ATP binding site [chemical binding]; other site 930171001828 Q-loop/lid; other site 930171001829 ABC transporter signature motif; other site 930171001830 Walker B; other site 930171001831 D-loop; other site 930171001832 H-loop/switch region; other site 930171001833 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171001834 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 930171001835 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171001836 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171001837 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171001838 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171001839 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171001840 DNA binding site [nucleotide binding] 930171001841 domain linker motif; other site 930171001842 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171001843 ligand binding site [chemical binding]; other site 930171001844 dimerization interface [polypeptide binding]; other site 930171001845 glucuronate isomerase; Reviewed; Region: PRK02925 930171001846 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 930171001847 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 930171001848 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 930171001849 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 930171001850 glucuronide transporter; Provisional; Region: PRK09848 930171001851 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 930171001852 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 930171001853 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 930171001854 metal binding site [ion binding]; metal-binding site 930171001855 substrate binding pocket [chemical binding]; other site 930171001856 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 930171001857 ATP-binding site [chemical binding]; other site 930171001858 Gluconate-6-phosphate binding site [chemical binding]; other site 930171001859 Shikimate kinase; Region: SKI; pfam01202 930171001860 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 930171001861 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 930171001862 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 930171001863 potential frameshift: common BLAST hit: gi|220914532|ref|YP_002489841.1| LacI family transcriptional regulator 930171001864 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171001865 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171001866 DNA binding site [nucleotide binding] 930171001867 domain linker motif; other site 930171001868 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 930171001869 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 930171001870 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171001871 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 930171001872 substrate binding site [chemical binding]; other site 930171001873 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 930171001874 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930171001875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171001876 dimer interface [polypeptide binding]; other site 930171001877 conserved gate region; other site 930171001878 putative PBP binding loops; other site 930171001879 ABC-ATPase subunit interface; other site 930171001880 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930171001881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171001882 dimer interface [polypeptide binding]; other site 930171001883 conserved gate region; other site 930171001884 putative PBP binding loops; other site 930171001885 ABC-ATPase subunit interface; other site 930171001886 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 930171001887 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171001888 Walker A/P-loop; other site 930171001889 ATP binding site [chemical binding]; other site 930171001890 Q-loop/lid; other site 930171001891 ABC transporter signature motif; other site 930171001892 Walker B; other site 930171001893 D-loop; other site 930171001894 H-loop/switch region; other site 930171001895 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171001896 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 930171001897 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171001898 Walker A/P-loop; other site 930171001899 ATP binding site [chemical binding]; other site 930171001900 Q-loop/lid; other site 930171001901 ABC transporter signature motif; other site 930171001902 Walker B; other site 930171001903 D-loop; other site 930171001904 H-loop/switch region; other site 930171001905 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 930171001906 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 930171001907 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 930171001908 substrate binding [chemical binding]; other site 930171001909 active site 930171001910 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 930171001911 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 930171001912 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 930171001913 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 930171001914 active site 930171001915 substrate binding [chemical binding]; other site 930171001916 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 930171001917 Domain of unknown function (DUF222); Region: DUF222; pfam02720 930171001918 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171001919 active site 930171001920 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 930171001921 putative NAD(P) binding site [chemical binding]; other site 930171001922 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 930171001923 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 930171001924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930171001925 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 930171001926 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 930171001927 nucleoside/Zn binding site; other site 930171001928 dimer interface [polypeptide binding]; other site 930171001929 catalytic motif [active] 930171001930 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 930171001931 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 930171001932 active site 930171001933 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930171001934 active site 930171001935 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 930171001936 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171001937 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 930171001938 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 930171001939 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 930171001940 N-acetyl-D-glucosamine binding site [chemical binding]; other site 930171001941 catalytic residue [active] 930171001942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930171001943 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 930171001944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930171001945 dimer interface [polypeptide binding]; other site 930171001946 phosphorylation site [posttranslational modification] 930171001947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171001948 ATP binding site [chemical binding]; other site 930171001949 Mg2+ binding site [ion binding]; other site 930171001950 G-X-G motif; other site 930171001951 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930171001952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171001953 active site 930171001954 phosphorylation site [posttranslational modification] 930171001955 intermolecular recognition site; other site 930171001956 dimerization interface [polypeptide binding]; other site 930171001957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930171001958 DNA binding site [nucleotide binding] 930171001959 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930171001960 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930171001961 DNA binding site [nucleotide binding] 930171001962 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930171001963 catalytic core [active] 930171001964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171001965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171001966 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 930171001967 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 930171001968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171001969 Walker A/P-loop; other site 930171001970 ATP binding site [chemical binding]; other site 930171001971 Q-loop/lid; other site 930171001972 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 930171001973 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171001974 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930171001975 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 930171001976 active site 930171001977 substrate-binding site [chemical binding]; other site 930171001978 metal-binding site [ion binding] 930171001979 GTP binding site [chemical binding]; other site 930171001980 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 930171001981 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 930171001982 heme-binding site [chemical binding]; other site 930171001983 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 930171001984 FAD binding pocket [chemical binding]; other site 930171001985 FAD binding motif [chemical binding]; other site 930171001986 phosphate binding motif [ion binding]; other site 930171001987 beta-alpha-beta structure motif; other site 930171001988 NAD binding pocket [chemical binding]; other site 930171001989 Heme binding pocket [chemical binding]; other site 930171001990 Transcriptional regulator; Region: Rrf2; cl17282 930171001991 Rrf2 family protein; Region: rrf2_super; TIGR00738 930171001992 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 930171001993 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 930171001994 active site 930171001995 substrate binding site [chemical binding]; other site 930171001996 metal binding site [ion binding]; metal-binding site 930171001997 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 930171001998 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171001999 ATP binding site [chemical binding]; other site 930171002000 putative Mg++ binding site [ion binding]; other site 930171002001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171002002 nucleotide binding region [chemical binding]; other site 930171002003 ATP-binding site [chemical binding]; other site 930171002004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002005 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171002006 putative substrate translocation pore; other site 930171002007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002008 Homeodomain-like domain; Region: HTH_23; pfam13384 930171002009 Winged helix-turn helix; Region: HTH_29; pfam13551 930171002010 Homeodomain-like domain; Region: HTH_32; pfam13565 930171002011 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 930171002012 Integrase core domain; Region: rve; pfam00665 930171002013 Integrase core domain; Region: rve_3; pfam13683 930171002014 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930171002015 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 930171002016 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930171002017 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 930171002018 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171002019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171002020 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171002021 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 930171002022 Helix-turn-helix domain; Region: HTH_38; pfam13936 930171002023 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 930171002024 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 930171002025 generic binding surface II; other site 930171002026 generic binding surface I; other site 930171002027 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 930171002028 putative active site [active] 930171002029 putative catalytic site [active] 930171002030 putative Mg binding site IVb [ion binding]; other site 930171002031 putative phosphate binding site [ion binding]; other site 930171002032 putative DNA binding site [nucleotide binding]; other site 930171002033 putative Mg binding site IVa [ion binding]; other site 930171002034 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 930171002035 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 930171002036 putative active site [active] 930171002037 putative metal binding site [ion binding]; other site 930171002038 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 930171002039 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 930171002040 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 930171002041 NAD(P) binding site [chemical binding]; other site 930171002042 Predicted transcriptional regulators [Transcription]; Region: COG1695 930171002043 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930171002044 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 930171002045 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 930171002046 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 930171002047 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 930171002048 Carbon starvation protein CstA; Region: CstA; pfam02554 930171002049 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 930171002050 Protein of unknown function (DUF466); Region: DUF466; pfam04328 930171002051 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 930171002052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171002053 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171002054 active site 930171002055 catalytic tetrad [active] 930171002056 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 930171002057 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171002058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171002059 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171002060 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 930171002061 TAP-like protein; Region: Abhydrolase_4; pfam08386 930171002062 DNA polymerase III subunit delta'; Validated; Region: PRK07940 930171002063 DNA polymerase III subunit delta'; Validated; Region: PRK08485 930171002064 thymidylate kinase; Validated; Region: tmk; PRK00698 930171002065 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 930171002066 TMP-binding site; other site 930171002067 ATP-binding site [chemical binding]; other site 930171002068 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 930171002069 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930171002070 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930171002071 catalytic residue [active] 930171002072 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 930171002073 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930171002074 catalytic core [active] 930171002075 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 930171002076 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 930171002077 PhoU domain; Region: PhoU; pfam01895 930171002078 PhoU domain; Region: PhoU; pfam01895 930171002079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930171002080 dimer interface [polypeptide binding]; other site 930171002081 phosphorylation site [posttranslational modification] 930171002082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171002083 ATP binding site [chemical binding]; other site 930171002084 Mg2+ binding site [ion binding]; other site 930171002085 G-X-G motif; other site 930171002086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930171002087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171002088 active site 930171002089 phosphorylation site [posttranslational modification] 930171002090 intermolecular recognition site; other site 930171002091 dimerization interface [polypeptide binding]; other site 930171002092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930171002093 DNA binding site [nucleotide binding] 930171002094 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 930171002095 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 930171002096 substrate binding site; other site 930171002097 dimer interface; other site 930171002098 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 930171002099 homotrimer interaction site [polypeptide binding]; other site 930171002100 zinc binding site [ion binding]; other site 930171002101 CDP-binding sites; other site 930171002102 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 930171002103 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930171002104 active site 930171002105 HIGH motif; other site 930171002106 nucleotide binding site [chemical binding]; other site 930171002107 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 930171002108 KMSKS motif; other site 930171002109 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 930171002110 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 930171002111 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 930171002112 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 930171002113 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 930171002114 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 930171002115 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 930171002116 active site 930171002117 catalytic site [active] 930171002118 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 930171002119 active site 930171002120 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 930171002121 putative RNAase interaction site [polypeptide binding]; other site 930171002122 thiamine pyrophosphate protein; Provisional; Region: PRK08273 930171002123 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 930171002124 PYR/PP interface [polypeptide binding]; other site 930171002125 dimer interface [polypeptide binding]; other site 930171002126 tetramer interface [polypeptide binding]; other site 930171002127 TPP binding site [chemical binding]; other site 930171002128 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930171002129 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 930171002130 TPP-binding site [chemical binding]; other site 930171002131 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 930171002132 putative homodimer interface [polypeptide binding]; other site 930171002133 putative active site pocket [active] 930171002134 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 930171002135 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 930171002136 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 930171002137 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 930171002138 active site 930171002139 homodimer interface [polypeptide binding]; other site 930171002140 catalytic site [active] 930171002141 acceptor binding site [chemical binding]; other site 930171002142 trehalose synthase; Region: treS_nterm; TIGR02456 930171002143 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 930171002144 active site 930171002145 catalytic site [active] 930171002146 glycogen branching enzyme; Provisional; Region: PRK14705 930171002147 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 930171002148 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 930171002149 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 930171002150 active site 930171002151 catalytic site [active] 930171002152 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 930171002153 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 930171002154 hydrophobic ligand binding site; other site 930171002155 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 930171002156 FAD binding domain; Region: FAD_binding_4; pfam01565 930171002157 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 930171002158 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 930171002159 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 930171002160 Walker A/P-loop; other site 930171002161 ATP binding site [chemical binding]; other site 930171002162 Q-loop/lid; other site 930171002163 ABC transporter signature motif; other site 930171002164 Walker B; other site 930171002165 D-loop; other site 930171002166 H-loop/switch region; other site 930171002167 TOBE domain; Region: TOBE; pfam03459 930171002168 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 930171002169 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 930171002170 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 930171002171 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 930171002172 active site 930171002173 homotetramer interface [polypeptide binding]; other site 930171002174 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 930171002175 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 930171002176 catalytic residues [active] 930171002177 ChaB; Region: ChaB; pfam06150 930171002178 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 930171002179 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 930171002180 elongation factor G; Reviewed; Region: PRK12740 930171002181 G1 box; other site 930171002182 putative GEF interaction site [polypeptide binding]; other site 930171002183 GTP/Mg2+ binding site [chemical binding]; other site 930171002184 Switch I region; other site 930171002185 G2 box; other site 930171002186 G3 box; other site 930171002187 Switch II region; other site 930171002188 G4 box; other site 930171002189 G5 box; other site 930171002190 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 930171002191 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 930171002192 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 930171002193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171002195 putative substrate translocation pore; other site 930171002196 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 930171002197 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 930171002198 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 930171002199 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 930171002200 dimerization interface [polypeptide binding]; other site 930171002201 DPS ferroxidase diiron center [ion binding]; other site 930171002202 ion pore; other site 930171002203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002204 putative substrate translocation pore; other site 930171002205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171002206 glycine dehydrogenase; Provisional; Region: PRK05367 930171002207 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 930171002208 tetramer interface [polypeptide binding]; other site 930171002209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171002210 catalytic residue [active] 930171002211 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 930171002212 tetramer interface [polypeptide binding]; other site 930171002213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171002214 catalytic residue [active] 930171002215 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 930171002216 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 930171002217 putative transposase OrfB; Reviewed; Region: PHA02517 930171002218 HTH-like domain; Region: HTH_21; pfam13276 930171002219 Integrase core domain; Region: rve; pfam00665 930171002220 Integrase core domain; Region: rve_3; pfam13683 930171002221 Transposase; Region: HTH_Tnp_1; pfam01527 930171002222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930171002223 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 930171002224 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 930171002225 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 930171002226 TspO/MBR family; Region: TspO_MBR; pfam03073 930171002227 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 930171002228 FemAB family; Region: FemAB; pfam02388 930171002229 Uncharacterized conserved protein [Function unknown]; Region: COG2966 930171002230 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 930171002231 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 930171002232 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 930171002233 FAD binding pocket [chemical binding]; other site 930171002234 FAD binding motif [chemical binding]; other site 930171002235 phosphate binding motif [ion binding]; other site 930171002236 NAD binding pocket [chemical binding]; other site 930171002237 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 930171002238 ligand binding site [chemical binding]; other site 930171002239 active site 930171002240 UGI interface [polypeptide binding]; other site 930171002241 catalytic site [active] 930171002242 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 930171002243 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 930171002244 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930171002245 DNA-binding site [nucleotide binding]; DNA binding site 930171002246 RNA-binding motif; other site 930171002247 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 930171002248 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 930171002249 ligand binding site [chemical binding]; other site 930171002250 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 930171002251 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 930171002252 ring oligomerisation interface [polypeptide binding]; other site 930171002253 ATP/Mg binding site [chemical binding]; other site 930171002254 stacking interactions; other site 930171002255 hinge regions; other site 930171002256 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171002257 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171002258 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 930171002259 RNA/DNA hybrid binding site [nucleotide binding]; other site 930171002260 active site 930171002261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 930171002262 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 930171002263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930171002264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930171002265 dimerization interface [polypeptide binding]; other site 930171002266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930171002267 dimer interface [polypeptide binding]; other site 930171002268 phosphorylation site [posttranslational modification] 930171002269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171002270 ATP binding site [chemical binding]; other site 930171002271 Mg2+ binding site [ion binding]; other site 930171002272 G-X-G motif; other site 930171002273 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930171002274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171002275 active site 930171002276 phosphorylation site [posttranslational modification] 930171002277 intermolecular recognition site; other site 930171002278 dimerization interface [polypeptide binding]; other site 930171002279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930171002280 DNA binding site [nucleotide binding] 930171002281 Domain of unknown function (DUF427); Region: DUF427; cl00998 930171002282 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 930171002283 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 930171002284 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 930171002285 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171002286 ATP binding site [chemical binding]; other site 930171002287 putative Mg++ binding site [ion binding]; other site 930171002288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171002289 nucleotide binding region [chemical binding]; other site 930171002290 ATP-binding site [chemical binding]; other site 930171002291 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 930171002292 WYL domain; Region: WYL; cl14852 930171002293 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930171002294 DNA-binding site [nucleotide binding]; DNA binding site 930171002295 RNA-binding motif; other site 930171002296 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 930171002297 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930171002298 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930171002299 catalytic residue [active] 930171002300 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 930171002301 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 930171002302 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 930171002303 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 930171002304 ydaO-yuaA leader 930171002305 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930171002306 Peptidase family M23; Region: Peptidase_M23; pfam01551 930171002307 ydaO-yuaA leader 930171002308 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 930171002309 NlpC/P60 family; Region: NLPC_P60; pfam00877 930171002310 NlpC/P60 family; Region: NLPC_P60; cl17555 930171002311 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 930171002312 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171002313 active site 930171002314 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 930171002315 GTP binding site; other site 930171002316 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 930171002317 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 930171002318 dimer interface [polypeptide binding]; other site 930171002319 putative functional site; other site 930171002320 putative MPT binding site; other site 930171002321 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 930171002322 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 930171002323 active site 930171002324 catalytic site [active] 930171002325 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 930171002326 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 930171002327 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930171002328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171002329 Walker A/P-loop; other site 930171002330 ATP binding site [chemical binding]; other site 930171002331 Q-loop/lid; other site 930171002332 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930171002333 ABC transporter signature motif; other site 930171002334 Walker B; other site 930171002335 D-loop; other site 930171002336 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930171002337 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930171002338 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930171002339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171002340 Walker A/P-loop; other site 930171002341 ATP binding site [chemical binding]; other site 930171002342 Q-loop/lid; other site 930171002343 ABC transporter signature motif; other site 930171002344 Walker B; other site 930171002345 D-loop; other site 930171002346 H-loop/switch region; other site 930171002347 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 930171002348 nudix motif; other site 930171002349 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 930171002350 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 930171002351 active site 930171002352 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 930171002353 Part of AAA domain; Region: AAA_19; pfam13245 930171002354 Family description; Region: UvrD_C_2; pfam13538 930171002355 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 930171002356 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 930171002357 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 930171002358 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 930171002359 CoA-ligase; Region: Ligase_CoA; pfam00549 930171002360 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 930171002361 CoA binding domain; Region: CoA_binding; smart00881 930171002362 CoA binding domain; Region: CoA_binding; cl17356 930171002363 CoA-ligase; Region: Ligase_CoA; pfam00549 930171002364 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 930171002365 putative hydrophobic ligand binding site [chemical binding]; other site 930171002366 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171002367 dimerization interface [polypeptide binding]; other site 930171002368 putative DNA binding site [nucleotide binding]; other site 930171002369 putative Zn2+ binding site [ion binding]; other site 930171002370 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 930171002371 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 930171002372 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930171002373 substrate binding site [chemical binding]; other site 930171002374 ATP binding site [chemical binding]; other site 930171002375 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 930171002376 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930171002377 PYR/PP interface [polypeptide binding]; other site 930171002378 dimer interface [polypeptide binding]; other site 930171002379 TPP binding site [chemical binding]; other site 930171002380 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930171002381 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 930171002382 TPP-binding site; other site 930171002383 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 930171002384 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 930171002385 tetrameric interface [polypeptide binding]; other site 930171002386 NAD binding site [chemical binding]; other site 930171002387 catalytic residues [active] 930171002388 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930171002389 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171002390 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171002391 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171002392 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930171002393 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 930171002394 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 930171002395 putative ligand binding site [chemical binding]; other site 930171002396 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930171002397 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930171002398 TM-ABC transporter signature motif; other site 930171002399 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930171002400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171002401 Walker A/P-loop; other site 930171002402 ATP binding site [chemical binding]; other site 930171002403 Q-loop/lid; other site 930171002404 ABC transporter signature motif; other site 930171002405 Walker B; other site 930171002406 D-loop; other site 930171002407 H-loop/switch region; other site 930171002408 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171002409 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171002410 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171002411 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 930171002412 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171002413 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171002414 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171002415 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930171002416 MarR family; Region: MarR; pfam01047 930171002417 MFS transport protein AraJ; Provisional; Region: PRK10091 930171002418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002419 KduI/IolB family; Region: KduI; pfam04962 930171002420 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930171002421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171002422 DNA-binding site [nucleotide binding]; DNA binding site 930171002423 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930171002424 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 930171002425 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 930171002426 active site 930171002427 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 930171002428 Na binding site [ion binding]; other site 930171002429 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 930171002430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171002431 non-specific DNA binding site [nucleotide binding]; other site 930171002432 salt bridge; other site 930171002433 sequence-specific DNA binding site [nucleotide binding]; other site 930171002434 Cupin domain; Region: Cupin_2; pfam07883 930171002435 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 930171002436 agmatinase; Region: agmatinase; TIGR01230 930171002437 oligomer interface [polypeptide binding]; other site 930171002438 putative active site [active] 930171002439 Mn binding site [ion binding]; other site 930171002440 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 930171002441 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930171002442 PYR/PP interface [polypeptide binding]; other site 930171002443 dimer interface [polypeptide binding]; other site 930171002444 TPP binding site [chemical binding]; other site 930171002445 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930171002446 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 930171002447 TPP-binding site [chemical binding]; other site 930171002448 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930171002449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171002450 putative DNA binding site [nucleotide binding]; other site 930171002451 putative Zn2+ binding site [ion binding]; other site 930171002452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002453 putative substrate translocation pore; other site 930171002454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930171002456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930171002457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171002458 Walker A/P-loop; other site 930171002459 ATP binding site [chemical binding]; other site 930171002460 Q-loop/lid; other site 930171002461 ABC transporter signature motif; other site 930171002462 Walker B; other site 930171002463 D-loop; other site 930171002464 H-loop/switch region; other site 930171002465 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930171002466 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930171002467 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 930171002468 Walker A/P-loop; other site 930171002469 ATP binding site [chemical binding]; other site 930171002470 Q-loop/lid; other site 930171002471 ABC transporter signature motif; other site 930171002472 Walker B; other site 930171002473 D-loop; other site 930171002474 H-loop/switch region; other site 930171002475 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 930171002476 active site 930171002477 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 930171002478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171002479 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 930171002480 Walker A motif; other site 930171002481 ATP binding site [chemical binding]; other site 930171002482 Walker B motif; other site 930171002483 arginine finger; other site 930171002484 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 930171002485 prefoldin subunit beta; Provisional; Region: PRK09343 930171002486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930171002487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930171002488 dimer interface [polypeptide binding]; other site 930171002489 phosphorylation site [posttranslational modification] 930171002490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171002491 ATP binding site [chemical binding]; other site 930171002492 Mg2+ binding site [ion binding]; other site 930171002493 G-X-G motif; other site 930171002494 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930171002495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171002496 active site 930171002497 phosphorylation site [posttranslational modification] 930171002498 intermolecular recognition site; other site 930171002499 dimerization interface [polypeptide binding]; other site 930171002500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930171002501 DNA binding site [nucleotide binding] 930171002502 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 930171002503 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 930171002504 additional DNA contacts [nucleotide binding]; other site 930171002505 mismatch recognition site; other site 930171002506 active site 930171002507 zinc binding site [ion binding]; other site 930171002508 DNA intercalation site [nucleotide binding]; other site 930171002509 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 930171002510 biotin synthase; Validated; Region: PRK06256 930171002511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930171002512 FeS/SAM binding site; other site 930171002513 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 930171002514 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 930171002515 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 930171002516 Na binding site [ion binding]; other site 930171002517 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 930171002518 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 930171002519 FMN binding site [chemical binding]; other site 930171002520 active site 930171002521 substrate binding site [chemical binding]; other site 930171002522 catalytic residue [active] 930171002523 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 930171002524 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 930171002525 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 930171002526 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 930171002527 RNA binding site [nucleotide binding]; other site 930171002528 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 930171002529 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 930171002530 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930171002531 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 930171002532 putative NAD(P) binding site [chemical binding]; other site 930171002533 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 930171002534 N-acetyl-D-glucosamine binding site [chemical binding]; other site 930171002535 catalytic residue [active] 930171002536 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930171002537 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 930171002538 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930171002539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171002540 ABC transporter signature motif; other site 930171002541 Walker B; other site 930171002542 D-loop; other site 930171002543 H-loop/switch region; other site 930171002544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171002545 Walker A/P-loop; other site 930171002546 ATP binding site [chemical binding]; other site 930171002547 Q-loop/lid; other site 930171002548 ABC transporter signature motif; other site 930171002549 Walker B; other site 930171002550 D-loop; other site 930171002551 H-loop/switch region; other site 930171002552 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 930171002553 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 930171002554 active site 930171002555 purine riboside binding site [chemical binding]; other site 930171002556 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 930171002557 Acylphosphatase; Region: Acylphosphatase; cl00551 930171002558 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 930171002559 RNase_H superfamily; Region: RNase_H_2; pfam13482 930171002560 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 930171002561 Part of AAA domain; Region: AAA_19; pfam13245 930171002562 AAA domain; Region: AAA_12; pfam13087 930171002563 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 930171002564 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930171002565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171002566 ATP binding site [chemical binding]; other site 930171002567 putative Mg++ binding site [ion binding]; other site 930171002568 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 930171002569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171002570 nucleotide binding region [chemical binding]; other site 930171002571 ATP-binding site [chemical binding]; other site 930171002572 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 930171002573 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 930171002574 putative molybdopterin cofactor binding site [chemical binding]; other site 930171002575 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 930171002576 putative molybdopterin cofactor binding site; other site 930171002577 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 930171002578 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 930171002579 NAD binding site [chemical binding]; other site 930171002580 catalytic Zn binding site [ion binding]; other site 930171002581 structural Zn binding site [ion binding]; other site 930171002582 Predicted acetyltransferase [General function prediction only]; Region: COG2388 930171002583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002584 putative substrate translocation pore; other site 930171002585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171002586 dimerization interface [polypeptide binding]; other site 930171002587 putative DNA binding site [nucleotide binding]; other site 930171002588 putative Zn2+ binding site [ion binding]; other site 930171002589 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 930171002590 putative hydrophobic ligand binding site [chemical binding]; other site 930171002591 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 930171002592 Mechanosensitive ion channel; Region: MS_channel; pfam00924 930171002593 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 930171002594 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 930171002595 active site 930171002596 catalytic site [active] 930171002597 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 930171002598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002599 putative substrate translocation pore; other site 930171002600 dimerization interface [polypeptide binding]; other site 930171002601 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 930171002602 putative active cleft [active] 930171002603 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 930171002604 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 930171002605 tetramerization interface [polypeptide binding]; other site 930171002606 NAD(P) binding site [chemical binding]; other site 930171002607 catalytic residues [active] 930171002608 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171002609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171002610 dimer interface [polypeptide binding]; other site 930171002611 conserved gate region; other site 930171002612 ABC-ATPase subunit interface; other site 930171002613 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 930171002614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171002615 dimer interface [polypeptide binding]; other site 930171002616 conserved gate region; other site 930171002617 putative PBP binding loops; other site 930171002618 ABC-ATPase subunit interface; other site 930171002619 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171002620 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171002621 Class I aldolases; Region: Aldolase_Class_I; cl17187 930171002622 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 930171002623 substrate binding site [chemical binding]; other site 930171002624 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930171002625 ATP binding site [chemical binding]; other site 930171002626 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171002627 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171002628 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171002629 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930171002630 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930171002631 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930171002632 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 930171002633 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 930171002634 putative ligand binding site [chemical binding]; other site 930171002635 putative NAD binding site [chemical binding]; other site 930171002636 catalytic site [active] 930171002637 H+ Antiporter protein; Region: 2A0121; TIGR00900 930171002638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002639 putative substrate translocation pore; other site 930171002640 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930171002641 MarR family; Region: MarR; pfam01047 930171002642 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 930171002643 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 930171002644 putative active site [active] 930171002645 putative metal binding site [ion binding]; other site 930171002646 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930171002647 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 930171002648 Protein of unknown function (DUF664); Region: DUF664; pfam04978 930171002649 DinB superfamily; Region: DinB_2; pfam12867 930171002650 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171002651 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930171002652 active site 930171002653 SnoaL-like domain; Region: SnoaL_3; pfam13474 930171002654 SnoaL-like domain; Region: SnoaL_2; pfam12680 930171002655 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171002656 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171002657 DNA binding residues [nucleotide binding] 930171002658 dimerization interface [polypeptide binding]; other site 930171002659 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930171002660 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930171002661 Walker A/P-loop; other site 930171002662 ATP binding site [chemical binding]; other site 930171002663 Q-loop/lid; other site 930171002664 ABC transporter signature motif; other site 930171002665 Walker B; other site 930171002666 D-loop; other site 930171002667 H-loop/switch region; other site 930171002668 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 930171002669 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 930171002670 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 930171002671 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 930171002672 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 930171002673 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930171002674 Domain of unknown function DUF21; Region: DUF21; pfam01595 930171002675 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930171002676 Transporter associated domain; Region: CorC_HlyC; smart01091 930171002677 SOUL heme-binding protein; Region: SOUL; pfam04832 930171002678 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 930171002679 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930171002680 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 930171002681 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 930171002682 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 930171002683 Excalibur calcium-binding domain; Region: Excalibur; smart00894 930171002684 bile acid transporter; Region: bass; TIGR00841 930171002685 Sodium Bile acid symporter family; Region: SBF; pfam01758 930171002686 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 930171002687 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 930171002688 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 930171002689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002690 putative substrate translocation pore; other site 930171002691 aldehyde oxidase; Region: PLN00192 930171002692 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 930171002693 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 930171002694 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 930171002695 Beta-lactamase; Region: Beta-lactamase; pfam00144 930171002696 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930171002697 Protein of unknown function (DUF998); Region: DUF998; pfam06197 930171002698 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171002699 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 930171002700 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171002701 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 930171002702 dimerization domain swap beta strand [polypeptide binding]; other site 930171002703 regulatory protein interface [polypeptide binding]; other site 930171002704 active site 930171002705 regulatory phosphorylation site [posttranslational modification]; other site 930171002706 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 930171002707 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 930171002708 active site 930171002709 P-loop; other site 930171002710 phosphorylation site [posttranslational modification] 930171002711 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930171002712 active site 930171002713 phosphorylation site [posttranslational modification] 930171002714 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 930171002715 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930171002716 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930171002717 GYD domain; Region: GYD; pfam08734 930171002718 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 930171002719 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 930171002720 potential catalytic triad [active] 930171002721 conserved cys residue [active] 930171002722 proline/glycine betaine transporter; Provisional; Region: PRK10642 930171002723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002724 putative substrate translocation pore; other site 930171002725 RibD C-terminal domain; Region: RibD_C; cl17279 930171002726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171002727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171002728 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 930171002729 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 930171002730 putative NAD(P) binding site [chemical binding]; other site 930171002731 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 930171002732 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930171002733 PYR/PP interface [polypeptide binding]; other site 930171002734 dimer interface [polypeptide binding]; other site 930171002735 TPP binding site [chemical binding]; other site 930171002736 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930171002737 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 930171002738 TPP-binding site [chemical binding]; other site 930171002739 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 930171002740 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 930171002741 AsnC family; Region: AsnC_trans_reg; pfam01037 930171002742 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 930171002743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171002744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171002745 homodimer interface [polypeptide binding]; other site 930171002746 catalytic residue [active] 930171002747 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 930171002748 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930171002749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171002750 DNA-binding site [nucleotide binding]; DNA binding site 930171002751 FCD domain; Region: FCD; pfam07729 930171002752 Predicted amidohydrolase [General function prediction only]; Region: COG0388 930171002753 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 930171002754 active site 930171002755 catalytic triad [active] 930171002756 dimer interface [polypeptide binding]; other site 930171002757 amino acid transporter; Region: 2A0306; TIGR00909 930171002758 Predicted amidohydrolase [General function prediction only]; Region: COG0388 930171002759 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 930171002760 putative active site [active] 930171002761 catalytic triad [active] 930171002762 putative dimer interface [polypeptide binding]; other site 930171002763 transposase; Provisional; Region: PRK06526 930171002764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171002765 Walker A motif; other site 930171002766 ATP binding site [chemical binding]; other site 930171002767 Walker B motif; other site 930171002768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 930171002769 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 930171002770 Integrase core domain; Region: rve; pfam00665 930171002771 AAA-like domain; Region: AAA_10; pfam12846 930171002772 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 930171002773 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 930171002774 cofactor binding site; other site 930171002775 DNA binding site [nucleotide binding] 930171002776 substrate interaction site [chemical binding]; other site 930171002777 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 930171002778 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 930171002779 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 930171002780 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 930171002781 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930171002782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171002783 Coenzyme A binding pocket [chemical binding]; other site 930171002784 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930171002785 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 930171002786 substrate binding site [chemical binding]; other site 930171002787 ATP binding site [chemical binding]; other site 930171002788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002789 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 930171002790 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 930171002791 active site 930171002792 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930171002793 nucleotide binding site [chemical binding]; other site 930171002794 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 930171002795 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 930171002796 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171002797 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171002798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930171002799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171002800 putative PBP binding loops; other site 930171002801 ABC-ATPase subunit interface; other site 930171002802 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171002803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171002804 dimer interface [polypeptide binding]; other site 930171002805 conserved gate region; other site 930171002806 putative PBP binding loops; other site 930171002807 ABC-ATPase subunit interface; other site 930171002808 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930171002809 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 930171002810 inhibitor binding site; inhibition site 930171002811 catalytic Zn binding site [ion binding]; other site 930171002812 structural Zn binding site [ion binding]; other site 930171002813 NADP binding site [chemical binding]; other site 930171002814 tetramer interface [polypeptide binding]; other site 930171002815 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 930171002816 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 930171002817 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 930171002818 potential frameshift: common BLAST hit: gi|116669576|ref|YP_830509.1| GntR family transcriptional regulator 930171002819 UTRA domain; Region: UTRA; cl17743 930171002820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171002821 DNA-binding site [nucleotide binding]; DNA binding site 930171002822 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 930171002823 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 930171002824 SnoaL-like domain; Region: SnoaL_2; pfam12680 930171002825 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 930171002826 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930171002827 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 930171002828 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930171002829 putative NAD(P) binding site [chemical binding]; other site 930171002830 catalytic Zn binding site [ion binding]; other site 930171002831 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 930171002832 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 930171002833 hydrophobic ligand binding site; other site 930171002834 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930171002835 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 930171002836 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 930171002837 NAD binding site [chemical binding]; other site 930171002838 substrate binding site [chemical binding]; other site 930171002839 catalytic Zn binding site [ion binding]; other site 930171002840 structural Zn binding site [ion binding]; other site 930171002841 Domain of unknown function DUF59; Region: DUF59; pfam01883 930171002842 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 930171002843 active site 930171002844 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 930171002845 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 930171002846 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 930171002847 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 930171002848 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 930171002849 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 930171002850 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171002851 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 930171002852 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171002853 benzoate transport; Region: 2A0115; TIGR00895 930171002854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171002855 putative substrate translocation pore; other site 930171002856 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 930171002857 Amidase; Region: Amidase; cl11426 930171002858 YciI-like protein; Reviewed; Region: PRK12866 930171002859 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930171002860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171002861 DNA-binding site [nucleotide binding]; DNA binding site 930171002862 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 930171002863 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 930171002864 hydrophobic ligand binding site; other site 930171002865 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930171002866 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930171002867 TM-ABC transporter signature motif; other site 930171002868 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 930171002869 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930171002870 Walker A/P-loop; other site 930171002871 ATP binding site [chemical binding]; other site 930171002872 Q-loop/lid; other site 930171002873 ABC transporter signature motif; other site 930171002874 Walker B; other site 930171002875 D-loop; other site 930171002876 H-loop/switch region; other site 930171002877 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930171002878 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 930171002879 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 930171002880 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930171002881 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 930171002882 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 930171002883 lac repressor; Reviewed; Region: lacI; PRK09526 930171002884 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171002885 DNA binding site [nucleotide binding] 930171002886 domain linker motif; other site 930171002887 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 930171002888 ligand binding site [chemical binding]; other site 930171002889 dimerization interface (open form) [polypeptide binding]; other site 930171002890 dimerization interface (closed form) [polypeptide binding]; other site 930171002891 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171002892 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171002893 DNA binding site [nucleotide binding] 930171002894 domain linker motif; other site 930171002895 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 930171002896 ligand binding site [chemical binding]; other site 930171002897 dimerization interface (open form) [polypeptide binding]; other site 930171002898 dimerization interface (closed form) [polypeptide binding]; other site 930171002899 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 930171002900 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 930171002901 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 930171002902 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930171002903 Walker A/P-loop; other site 930171002904 ATP binding site [chemical binding]; other site 930171002905 Q-loop/lid; other site 930171002906 ABC transporter signature motif; other site 930171002907 Walker B; other site 930171002908 D-loop; other site 930171002909 H-loop/switch region; other site 930171002910 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930171002911 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930171002912 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930171002913 TM-ABC transporter signature motif; other site 930171002914 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930171002915 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171002916 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171002917 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171002918 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930171002919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171002920 DNA-binding site [nucleotide binding]; DNA binding site 930171002921 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930171002922 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 930171002923 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930171002924 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930171002925 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930171002926 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 930171002927 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 930171002928 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 930171002929 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 930171002930 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 930171002931 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930171002932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171002933 dimer interface [polypeptide binding]; other site 930171002934 conserved gate region; other site 930171002935 putative PBP binding loops; other site 930171002936 ABC-ATPase subunit interface; other site 930171002937 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930171002938 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 930171002939 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171002940 Walker A/P-loop; other site 930171002941 ATP binding site [chemical binding]; other site 930171002942 Q-loop/lid; other site 930171002943 ABC transporter signature motif; other site 930171002944 Walker B; other site 930171002945 D-loop; other site 930171002946 H-loop/switch region; other site 930171002947 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171002948 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 930171002949 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171002950 Walker A/P-loop; other site 930171002951 ATP binding site [chemical binding]; other site 930171002952 Q-loop/lid; other site 930171002953 ABC transporter signature motif; other site 930171002954 Walker B; other site 930171002955 D-loop; other site 930171002956 H-loop/switch region; other site 930171002957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171002958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171002959 active site 930171002960 catalytic tetrad [active] 930171002961 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 930171002962 BNR repeat-like domain; Region: BNR_2; pfam13088 930171002963 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 930171002964 Asp-box motif; other site 930171002965 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 930171002966 classical (c) SDRs; Region: SDR_c; cd05233 930171002967 NAD(P) binding site [chemical binding]; other site 930171002968 active site 930171002969 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930171002970 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930171002971 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 930171002972 Hemerythrin-like domain; Region: Hr-like; cd12108 930171002973 Fe binding site [ion binding]; other site 930171002974 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 930171002975 active site 930171002976 catalytic residues [active] 930171002977 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 930171002978 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 930171002979 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 930171002980 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 930171002981 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930171002982 DNA-binding site [nucleotide binding]; DNA binding site 930171002983 RNA-binding motif; other site 930171002984 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 930171002985 Lipase (class 2); Region: Lipase_2; pfam01674 930171002986 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930171002987 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171002988 DNA-binding site [nucleotide binding]; DNA binding site 930171002989 FCD domain; Region: FCD; pfam07729 930171002990 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 930171002991 AAA domain; Region: AAA_33; pfam13671 930171002992 ATP-binding site [chemical binding]; other site 930171002993 Gluconate-6-phosphate binding site [chemical binding]; other site 930171002994 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 930171002995 fructuronate transporter; Provisional; Region: PRK10034; cl15264 930171002996 PhoD-like phosphatase; Region: PhoD; pfam09423 930171002997 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 930171002998 putative active site [active] 930171002999 putative metal binding site [ion binding]; other site 930171003000 TfoX N-terminal domain; Region: TfoX_N; cl17592 930171003001 short chain dehydrogenase; Provisional; Region: PRK06197 930171003002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171003003 NAD(P) binding site [chemical binding]; other site 930171003004 active site 930171003005 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 930171003006 EamA-like transporter family; Region: EamA; pfam00892 930171003007 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 930171003008 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930171003009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171003010 DNA-binding site [nucleotide binding]; DNA binding site 930171003011 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171003012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171003013 homodimer interface [polypeptide binding]; other site 930171003014 catalytic residue [active] 930171003015 S-methylmethionine transporter; Provisional; Region: PRK11387 930171003016 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171003017 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 930171003018 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171003019 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171003020 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 930171003021 non-specific DNA interactions [nucleotide binding]; other site 930171003022 DNA binding site [nucleotide binding] 930171003023 sequence specific DNA binding site [nucleotide binding]; other site 930171003024 putative cAMP binding site [chemical binding]; other site 930171003025 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171003026 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 930171003027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 930171003028 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 930171003029 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 930171003030 RibD C-terminal domain; Region: RibD_C; cl17279 930171003031 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 930171003032 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930171003033 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930171003034 metal binding site [ion binding]; metal-binding site 930171003035 active site 930171003036 I-site; other site 930171003037 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930171003038 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 930171003039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171003040 active site 930171003041 motif I; other site 930171003042 motif II; other site 930171003043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171003044 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 930171003045 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 930171003046 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 930171003047 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 930171003048 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930171003049 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 930171003050 PRC-barrel domain; Region: PRC; pfam05239 930171003051 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 930171003052 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 930171003053 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 930171003054 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 930171003055 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 930171003056 active site 930171003057 substrate binding site [chemical binding]; other site 930171003058 cosubstrate binding site; other site 930171003059 catalytic site [active] 930171003060 benzoate transport; Region: 2A0115; TIGR00895 930171003061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171003062 putative substrate translocation pore; other site 930171003063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171003064 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 930171003065 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 930171003066 purine monophosphate binding site [chemical binding]; other site 930171003067 dimer interface [polypeptide binding]; other site 930171003068 putative catalytic residues [active] 930171003069 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 930171003070 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 930171003071 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 930171003072 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 930171003073 hydroperoxidase II; Provisional; Region: katE; PRK11249 930171003074 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 930171003075 heme binding pocket [chemical binding]; other site 930171003076 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 930171003077 domain interactions; other site 930171003078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930171003079 Catalytic domain of Protein Kinases; Region: PKc; cd00180 930171003080 active site 930171003081 ATP binding site [chemical binding]; other site 930171003082 substrate binding site [chemical binding]; other site 930171003083 activation loop (A-loop); other site 930171003084 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171003085 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171003086 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171003087 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 930171003088 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 930171003089 putative ligand binding site [chemical binding]; other site 930171003090 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930171003091 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930171003092 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930171003093 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930171003094 TM-ABC transporter signature motif; other site 930171003095 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 930171003096 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930171003097 Walker A/P-loop; other site 930171003098 ATP binding site [chemical binding]; other site 930171003099 Q-loop/lid; other site 930171003100 ABC transporter signature motif; other site 930171003101 Walker B; other site 930171003102 D-loop; other site 930171003103 H-loop/switch region; other site 930171003104 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930171003105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171003106 dimerization interface [polypeptide binding]; other site 930171003107 putative DNA binding site [nucleotide binding]; other site 930171003108 putative Zn2+ binding site [ion binding]; other site 930171003109 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930171003110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930171003111 nucleotide binding site [chemical binding]; other site 930171003112 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930171003113 Predicted amidohydrolase [General function prediction only]; Region: COG0388 930171003114 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 930171003115 active site 930171003116 catalytic triad [active] 930171003117 dimer interface [polypeptide binding]; other site 930171003118 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 930171003119 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930171003120 amino acid transporter; Region: 2A0306; TIGR00909 930171003121 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 930171003122 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930171003123 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 930171003124 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 930171003125 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 930171003126 trimer interface [polypeptide binding]; other site 930171003127 putative metal binding site [ion binding]; other site 930171003128 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 930171003129 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 930171003130 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 930171003131 putative active site [active] 930171003132 putative substrate binding site [chemical binding]; other site 930171003133 putative cosubstrate binding site; other site 930171003134 catalytic site [active] 930171003135 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 930171003136 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 930171003137 dimer interface [polypeptide binding]; other site 930171003138 active site 930171003139 glycine-pyridoxal phosphate binding site [chemical binding]; other site 930171003140 folate binding site [chemical binding]; other site 930171003141 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 930171003142 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 930171003143 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 930171003144 NAD(P) binding pocket [chemical binding]; other site 930171003145 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930171003146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171003147 Walker A/P-loop; other site 930171003148 ATP binding site [chemical binding]; other site 930171003149 Q-loop/lid; other site 930171003150 ABC transporter signature motif; other site 930171003151 Walker B; other site 930171003152 D-loop; other site 930171003153 H-loop/switch region; other site 930171003154 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930171003155 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930171003156 ABC-2 type transporter; Region: ABC2_membrane; cl17235 930171003157 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930171003158 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 930171003159 putative active site [active] 930171003160 putative catalytic site [active] 930171003161 putative DNA binding site [nucleotide binding]; other site 930171003162 putative phosphate binding site [ion binding]; other site 930171003163 metal binding site A [ion binding]; metal-binding site 930171003164 putative AP binding site [nucleotide binding]; other site 930171003165 putative metal binding site B [ion binding]; other site 930171003166 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 930171003167 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 930171003168 active site 930171003169 HIGH motif; other site 930171003170 dimer interface [polypeptide binding]; other site 930171003171 KMSKS motif; other site 930171003172 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 930171003173 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 930171003174 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 930171003175 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171003176 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 930171003177 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 930171003178 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 930171003179 L-aspartate oxidase; Provisional; Region: PRK06175 930171003180 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 930171003181 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 930171003182 putative Iron-sulfur protein interface [polypeptide binding]; other site 930171003183 putative proximal heme binding site [chemical binding]; other site 930171003184 putative SdhC-like subunit interface [polypeptide binding]; other site 930171003185 putative distal heme binding site [chemical binding]; other site 930171003186 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 930171003187 putative Iron-sulfur protein interface [polypeptide binding]; other site 930171003188 putative proximal heme binding site [chemical binding]; other site 930171003189 putative SdhD-like interface [polypeptide binding]; other site 930171003190 putative distal heme binding site [chemical binding]; other site 930171003191 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 930171003192 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 930171003193 Substrate binding site; other site 930171003194 Cupin domain; Region: Cupin_2; cl17218 930171003195 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930171003196 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 930171003197 metal binding site [ion binding]; metal-binding site 930171003198 putative dimer interface [polypeptide binding]; other site 930171003199 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930171003200 MarR family; Region: MarR_2; cl17246 930171003201 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 930171003202 Prostaglandin dehydrogenases; Region: PGDH; cd05288 930171003203 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 930171003204 NAD(P) binding site [chemical binding]; other site 930171003205 substrate binding site [chemical binding]; other site 930171003206 dimer interface [polypeptide binding]; other site 930171003207 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 930171003208 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 930171003209 ligand binding site [chemical binding]; other site 930171003210 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 930171003211 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930171003212 Walker A/P-loop; other site 930171003213 ATP binding site [chemical binding]; other site 930171003214 Q-loop/lid; other site 930171003215 ABC transporter signature motif; other site 930171003216 Walker B; other site 930171003217 D-loop; other site 930171003218 H-loop/switch region; other site 930171003219 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930171003220 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930171003221 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 930171003222 TM-ABC transporter signature motif; other site 930171003223 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930171003224 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 930171003225 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 930171003226 TM-ABC transporter signature motif; other site 930171003227 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 930171003228 active site 930171003229 catalytic motif [active] 930171003230 Zn binding site [ion binding]; other site 930171003231 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930171003232 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930171003233 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930171003234 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930171003235 adenosine deaminase; Provisional; Region: PRK09358 930171003236 active site 930171003237 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 930171003238 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 930171003239 homodimer interface [polypeptide binding]; other site 930171003240 metal binding site [ion binding]; metal-binding site 930171003241 enolase; Provisional; Region: eno; PRK00077 930171003242 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 930171003243 dimer interface [polypeptide binding]; other site 930171003244 metal binding site [ion binding]; metal-binding site 930171003245 substrate binding pocket [chemical binding]; other site 930171003246 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 930171003247 Septum formation initiator; Region: DivIC; pfam04977 930171003248 Protein of unknown function (DUF501); Region: DUF501; pfam04417 930171003249 exopolyphosphatase; Region: exo_poly_only; TIGR03706 930171003250 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 930171003251 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 930171003252 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 930171003253 active site 930171003254 catalytic residues [active] 930171003255 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 930171003256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171003257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 930171003258 ACT domain; Region: ACT_3; pfam10000 930171003259 Family description; Region: ACT_7; pfam13840 930171003260 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930171003261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171003262 Coenzyme A binding pocket [chemical binding]; other site 930171003263 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 930171003264 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 930171003265 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 930171003266 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 930171003267 Walker A/P-loop; other site 930171003268 ATP binding site [chemical binding]; other site 930171003269 Q-loop/lid; other site 930171003270 ABC transporter signature motif; other site 930171003271 Walker B; other site 930171003272 D-loop; other site 930171003273 H-loop/switch region; other site 930171003274 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 930171003275 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 930171003276 Walker A/P-loop; other site 930171003277 ATP binding site [chemical binding]; other site 930171003278 Q-loop/lid; other site 930171003279 ABC transporter signature motif; other site 930171003280 Walker B; other site 930171003281 D-loop; other site 930171003282 H-loop/switch region; other site 930171003283 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 930171003284 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 930171003285 TM-ABC transporter signature motif; other site 930171003286 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 930171003287 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 930171003288 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930171003289 TM-ABC transporter signature motif; other site 930171003290 Bax inhibitor 1 like; Region: BaxI_1; cl17691 930171003291 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 930171003292 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 930171003293 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 930171003294 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 930171003295 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 930171003296 dimer interface [polypeptide binding]; other site 930171003297 active site 930171003298 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 930171003299 active site 930171003300 catalytic residues [active] 930171003301 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930171003302 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930171003303 threonine dehydratase; Provisional; Region: PRK08198 930171003304 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 930171003305 tetramer interface [polypeptide binding]; other site 930171003306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171003307 catalytic residue [active] 930171003308 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 930171003309 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 930171003310 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 930171003311 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 930171003312 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 930171003313 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 930171003314 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 930171003315 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 930171003316 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 930171003317 catalytic residue [active] 930171003318 putative FPP diphosphate binding site; other site 930171003319 putative FPP binding hydrophobic cleft; other site 930171003320 dimer interface [polypeptide binding]; other site 930171003321 putative IPP diphosphate binding site; other site 930171003322 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 930171003323 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 930171003324 putative active site [active] 930171003325 PhoH-like protein; Region: PhoH; pfam02562 930171003326 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930171003327 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 930171003328 fumarate hydratase; Reviewed; Region: fumC; PRK00485 930171003329 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 930171003330 active sites [active] 930171003331 tetramer interface [polypeptide binding]; other site 930171003332 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 930171003333 active site clefts [active] 930171003334 zinc binding site [ion binding]; other site 930171003335 dimer interface [polypeptide binding]; other site 930171003336 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 930171003337 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 930171003338 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 930171003339 putative active site [active] 930171003340 FemAB family; Region: FemAB; pfam02388 930171003341 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 930171003342 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 930171003343 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 930171003344 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 930171003345 Transcriptional regulator [Transcription]; Region: LytR; COG1316 930171003346 AIR carboxylase; Region: AIRC; pfam00731 930171003347 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 930171003348 LabA_like proteins; Region: LabA_like/DUF88; cl10034 930171003349 ATP-grasp domain; Region: ATP-grasp; pfam02222 930171003350 Predicted membrane protein [Function unknown]; Region: COG2246 930171003351 GtrA-like protein; Region: GtrA; pfam04138 930171003352 TIGR03089 family protein; Region: TIGR03089 930171003353 Transcription factor WhiB; Region: Whib; pfam02467 930171003354 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 930171003355 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 930171003356 Adenosylhomocysteinase; Provisional; Region: PTZ00075 930171003357 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 930171003358 homotetramer interface [polypeptide binding]; other site 930171003359 ligand binding site [chemical binding]; other site 930171003360 catalytic site [active] 930171003361 NAD binding site [chemical binding]; other site 930171003362 Bacterial Ig-like domain; Region: Big_5; pfam13205 930171003363 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 930171003364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 930171003365 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 930171003366 RDD family; Region: RDD; pfam06271 930171003367 Integral membrane protein DUF95; Region: DUF95; pfam01944 930171003368 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 930171003369 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 930171003370 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 930171003371 acyl-activating enzyme (AAE) consensus motif; other site 930171003372 putative AMP binding site [chemical binding]; other site 930171003373 putative active site [active] 930171003374 putative CoA binding site [chemical binding]; other site 930171003375 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 930171003376 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 930171003377 Predicted methyltransferases [General function prediction only]; Region: COG0313 930171003378 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 930171003379 putative SAM binding site [chemical binding]; other site 930171003380 putative homodimer interface [polypeptide binding]; other site 930171003381 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930171003382 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 930171003383 tetramerization interface [polypeptide binding]; other site 930171003384 NAD(P) binding site [chemical binding]; other site 930171003385 catalytic residues [active] 930171003386 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 930171003387 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 930171003388 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 930171003389 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 930171003390 Protein of unknown function DUF58; Region: DUF58; pfam01882 930171003391 MoxR-like ATPases [General function prediction only]; Region: COG0714 930171003392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171003393 Walker A motif; other site 930171003394 ATP binding site [chemical binding]; other site 930171003395 Walker B motif; other site 930171003396 arginine finger; other site 930171003397 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 930171003398 active site 930171003399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 930171003400 G5 domain; Region: G5; pfam07501 930171003401 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 930171003402 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 930171003403 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 930171003404 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 930171003405 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 930171003406 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930171003407 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930171003408 ABC transporter; Region: ABC_tran_2; pfam12848 930171003409 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930171003410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171003411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171003412 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 930171003413 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 930171003414 Substrate binding site; other site 930171003415 Mg++ binding site; other site 930171003416 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 930171003417 active site 930171003418 substrate binding site [chemical binding]; other site 930171003419 CoA binding site [chemical binding]; other site 930171003420 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 930171003421 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 930171003422 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930171003423 active site 930171003424 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 930171003425 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 930171003426 5S rRNA interface [nucleotide binding]; other site 930171003427 CTC domain interface [polypeptide binding]; other site 930171003428 L16 interface [polypeptide binding]; other site 930171003429 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 930171003430 putative active site [active] 930171003431 catalytic residue [active] 930171003432 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171003433 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171003434 DNA binding residues [nucleotide binding] 930171003435 dimerization interface [polypeptide binding]; other site 930171003436 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171003437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171003438 DNA binding residues [nucleotide binding] 930171003439 dimerization interface [polypeptide binding]; other site 930171003440 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 930171003441 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 930171003442 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930171003443 catalytic residue [active] 930171003444 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 930171003445 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 930171003446 trimerization site [polypeptide binding]; other site 930171003447 active site 930171003448 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 930171003449 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 930171003450 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 930171003451 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171003452 ATP binding site [chemical binding]; other site 930171003453 putative Mg++ binding site [ion binding]; other site 930171003454 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171003455 nucleotide binding region [chemical binding]; other site 930171003456 ATP-binding site [chemical binding]; other site 930171003457 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 930171003458 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 930171003459 intersubunit interface [polypeptide binding]; other site 930171003460 active site 930171003461 catalytic residue [active] 930171003462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 930171003463 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 930171003464 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 930171003465 active site 930171003466 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 930171003467 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 930171003468 active site 930171003469 SAM binding site [chemical binding]; other site 930171003470 homodimer interface [polypeptide binding]; other site 930171003471 nitrite reductase subunit NirD; Provisional; Region: PRK14989 930171003472 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 930171003473 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 930171003474 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 930171003475 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 930171003476 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 930171003477 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 930171003478 active site 930171003479 substrate binding site [chemical binding]; other site 930171003480 metal binding site [ion binding]; metal-binding site 930171003481 purine nucleoside phosphorylase; Provisional; Region: PRK08202 930171003482 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 930171003483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171003484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171003485 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930171003486 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 930171003487 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 930171003488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930171003489 FeS/SAM binding site; other site 930171003490 PspC domain; Region: PspC; pfam04024 930171003491 Flavodoxin domain; Region: Flavodoxin_5; cl17428 930171003492 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 930171003493 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 930171003494 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 930171003495 [4Fe-4S] binding site [ion binding]; other site 930171003496 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 930171003497 molybdopterin cofactor binding site; other site 930171003498 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 930171003499 molybdopterin cofactor binding site; other site 930171003500 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 930171003501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171003502 metabolite-proton symporter; Region: 2A0106; TIGR00883 930171003503 putative substrate translocation pore; other site 930171003504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171003505 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 930171003506 catalytic triad [active] 930171003507 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 930171003508 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 930171003509 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930171003510 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 930171003511 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 930171003512 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930171003513 carboxyltransferase (CT) interaction site; other site 930171003514 biotinylation site [posttranslational modification]; other site 930171003515 Maf-like protein; Region: Maf; pfam02545 930171003516 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 930171003517 active site 930171003518 dimer interface [polypeptide binding]; other site 930171003519 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 930171003520 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 930171003521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171003522 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 930171003523 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 930171003524 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 930171003525 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 930171003526 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 930171003527 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 930171003528 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 930171003529 short chain dehydrogenase; Provisional; Region: PRK08278 930171003530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171003531 NAD(P) binding site [chemical binding]; other site 930171003532 active site 930171003533 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 930171003534 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 930171003535 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 930171003536 Bacterial PH domain; Region: DUF304; pfam03703 930171003537 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 930171003538 cyclase homology domain; Region: CHD; cd07302 930171003539 nucleotidyl binding site; other site 930171003540 metal binding site [ion binding]; metal-binding site 930171003541 dimer interface [polypeptide binding]; other site 930171003542 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930171003543 Interdomain contacts; other site 930171003544 Cytokine receptor motif; other site 930171003545 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930171003546 Interdomain contacts; other site 930171003547 Cytokine receptor motif; other site 930171003548 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930171003549 Interdomain contacts; other site 930171003550 Cytokine receptor motif; other site 930171003551 MoxR-like ATPases [General function prediction only]; Region: COG0714 930171003552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171003553 Walker A motif; other site 930171003554 ATP binding site [chemical binding]; other site 930171003555 Walker B motif; other site 930171003556 arginine finger; other site 930171003557 Protein of unknown function DUF58; Region: DUF58; pfam01882 930171003558 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 930171003559 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 930171003560 RDD family; Region: RDD; pfam06271 930171003561 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 930171003562 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 930171003563 Protein phosphatase 2C; Region: PP2C; pfam00481 930171003564 active site 930171003565 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 930171003566 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930171003567 Catalytic domain of Protein Kinases; Region: PKc; cd00180 930171003568 active site 930171003569 ATP binding site [chemical binding]; other site 930171003570 substrate binding site [chemical binding]; other site 930171003571 activation loop (A-loop); other site 930171003572 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 930171003573 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 930171003574 phosphopeptide binding site; other site 930171003575 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 930171003576 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930171003577 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930171003578 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 930171003579 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 930171003580 nucleotide binding pocket [chemical binding]; other site 930171003581 K-X-D-G motif; other site 930171003582 catalytic site [active] 930171003583 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 930171003584 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 930171003585 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 930171003586 Dimer interface [polypeptide binding]; other site 930171003587 BRCT sequence motif; other site 930171003588 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 930171003589 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 930171003590 active site 930171003591 dimerization interface [polypeptide binding]; other site 930171003592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930171003593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171003594 Coenzyme A binding pocket [chemical binding]; other site 930171003595 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 930171003596 homotrimer interaction site [polypeptide binding]; other site 930171003597 putative active site [active] 930171003598 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 930171003599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171003600 active site 930171003601 phosphorylation site [posttranslational modification] 930171003602 intermolecular recognition site; other site 930171003603 dimerization interface [polypeptide binding]; other site 930171003604 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 930171003605 PAS fold; Region: PAS; pfam00989 930171003606 PAS domain; Region: PAS; smart00091 930171003607 heme pocket [chemical binding]; other site 930171003608 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 930171003609 Citrate transporter; Region: CitMHS; pfam03600 930171003610 Citrate transporter; Region: CitMHS; pfam03600 930171003611 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 930171003612 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 930171003613 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 930171003614 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 930171003615 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 930171003616 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 930171003617 GatB domain; Region: GatB_Yqey; smart00845 930171003618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930171003619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171003620 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 930171003621 dimerization interface [polypeptide binding]; other site 930171003622 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 930171003623 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 930171003624 NAD(P) binding site [chemical binding]; other site 930171003625 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 930171003626 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 930171003627 substrate-cofactor binding pocket; other site 930171003628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171003629 catalytic residue [active] 930171003630 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930171003631 imidazolonepropionase; Provisional; Region: PRK14085 930171003632 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930171003633 active site 930171003634 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930171003635 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 930171003636 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930171003637 CAAX protease self-immunity; Region: Abi; pfam02517 930171003638 Domain of unknown function (DUF222); Region: DUF222; pfam02720 930171003639 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171003640 active site 930171003641 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 930171003642 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 930171003643 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930171003644 homodimer interface [polypeptide binding]; other site 930171003645 substrate-cofactor binding pocket; other site 930171003646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171003647 catalytic residue [active] 930171003648 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 930171003649 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 930171003650 metabolite-proton symporter; Region: 2A0106; TIGR00883 930171003651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171003652 putative substrate translocation pore; other site 930171003653 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 930171003654 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 930171003655 NAD(P) binding site [chemical binding]; other site 930171003656 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930171003657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171003658 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 930171003659 dimerization interface [polypeptide binding]; other site 930171003660 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930171003661 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 930171003662 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 930171003663 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 930171003664 tetrameric interface [polypeptide binding]; other site 930171003665 NAD binding site [chemical binding]; other site 930171003666 catalytic residues [active] 930171003667 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 930171003668 active site 930171003669 catalytic triad [active] 930171003670 oxyanion hole [active] 930171003671 Predicted esterase [General function prediction only]; Region: COG0400 930171003672 putative hydrolase; Provisional; Region: PRK11460 930171003673 S4 domain; Region: S4_2; pfam13275 930171003674 Protein of unknown function, DUF606; Region: DUF606; pfam04657 930171003675 Protein of unknown function, DUF606; Region: DUF606; pfam04657 930171003676 glycyl-tRNA synthetase; Provisional; Region: PRK04173 930171003677 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 930171003678 motif 1; other site 930171003679 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 930171003680 active site 930171003681 motif 2; other site 930171003682 motif 3; other site 930171003683 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 930171003684 anticodon binding site; other site 930171003685 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930171003686 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 930171003687 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 930171003688 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 930171003689 nucleophilic elbow; other site 930171003690 catalytic site [active] 930171003691 catalytic triad; other site 930171003692 YibE/F-like protein; Region: YibE_F; pfam07907 930171003693 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 930171003694 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 930171003695 FMN binding site [chemical binding]; other site 930171003696 active site 930171003697 catalytic residues [active] 930171003698 substrate binding site [chemical binding]; other site 930171003699 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 930171003700 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930171003701 Zn2+ binding site [ion binding]; other site 930171003702 Mg2+ binding site [ion binding]; other site 930171003703 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 930171003704 DNA primase; Validated; Region: dnaG; PRK05667 930171003705 CHC2 zinc finger; Region: zf-CHC2; pfam01807 930171003706 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 930171003707 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 930171003708 active site 930171003709 metal binding site [ion binding]; metal-binding site 930171003710 interdomain interaction site; other site 930171003711 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 930171003712 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 930171003713 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 930171003714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171003715 putative substrate translocation pore; other site 930171003716 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 930171003717 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 930171003718 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 930171003719 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930171003720 putative ADP-binding pocket [chemical binding]; other site 930171003721 acyl-coenzyme A oxidase; Region: PLN02526 930171003722 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930171003723 active site 930171003724 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930171003725 Peptidase family M23; Region: Peptidase_M23; pfam01551 930171003726 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 930171003727 rRNA interaction site [nucleotide binding]; other site 930171003728 S8 interaction site; other site 930171003729 putative laminin-1 binding site; other site 930171003730 elongation factor Ts; Provisional; Region: tsf; PRK09377 930171003731 UBA/TS-N domain; Region: UBA; pfam00627 930171003732 Elongation factor TS; Region: EF_TS; pfam00889 930171003733 Elongation factor TS; Region: EF_TS; pfam00889 930171003734 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 930171003735 putative nucleotide binding site [chemical binding]; other site 930171003736 uridine monophosphate binding site [chemical binding]; other site 930171003737 homohexameric interface [polypeptide binding]; other site 930171003738 ribosome recycling factor; Reviewed; Region: frr; PRK00083 930171003739 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 930171003740 hinge region; other site 930171003741 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 930171003742 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 930171003743 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 930171003744 DivIVA domain; Region: DivI1A_domain; TIGR03544 930171003745 DivIVA domain; Region: DivI1A_domain; TIGR03544 930171003746 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 930171003747 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 930171003748 Na binding site [ion binding]; other site 930171003749 Protein of unknown function, DUF485; Region: DUF485; pfam04341 930171003750 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 930171003751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171003752 active site 930171003753 phosphorylation site [posttranslational modification] 930171003754 intermolecular recognition site; other site 930171003755 dimerization interface [polypeptide binding]; other site 930171003756 LytTr DNA-binding domain; Region: LytTR; smart00850 930171003757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 930171003758 Histidine kinase; Region: His_kinase; pfam06580 930171003759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171003760 ATP binding site [chemical binding]; other site 930171003761 Mg2+ binding site [ion binding]; other site 930171003762 G-X-G motif; other site 930171003763 Protein of unknown function, DUF485; Region: DUF485; pfam04341 930171003764 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 930171003765 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 930171003766 Na binding site [ion binding]; other site 930171003767 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930171003768 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 930171003769 putative DNA binding site [nucleotide binding]; other site 930171003770 putative Zn2+ binding site [ion binding]; other site 930171003771 AsnC family; Region: AsnC_trans_reg; pfam01037 930171003772 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 930171003773 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 930171003774 tetramer interface [polypeptide binding]; other site 930171003775 TPP-binding site [chemical binding]; other site 930171003776 heterodimer interface [polypeptide binding]; other site 930171003777 phosphorylation loop region [posttranslational modification] 930171003778 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 930171003779 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 930171003780 alpha subunit interface [polypeptide binding]; other site 930171003781 TPP binding site [chemical binding]; other site 930171003782 heterodimer interface [polypeptide binding]; other site 930171003783 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930171003784 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930171003785 E3 interaction surface; other site 930171003786 lipoyl attachment site [posttranslational modification]; other site 930171003787 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 930171003788 e3 binding domain; Region: E3_binding; pfam02817 930171003789 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930171003790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171003791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171003792 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 930171003793 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 930171003794 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 930171003795 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 930171003796 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930171003797 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930171003798 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 930171003799 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930171003800 carboxyltransferase (CT) interaction site; other site 930171003801 biotinylation site [posttranslational modification]; other site 930171003802 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 930171003803 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930171003804 active site 930171003805 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 930171003806 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 930171003807 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 930171003808 putative active site [active] 930171003809 putative catalytic site [active] 930171003810 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 930171003811 Lipase maturation factor; Region: LMF1; pfam06762 930171003812 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930171003813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930171003814 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 930171003815 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 930171003816 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 930171003817 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 930171003818 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 930171003819 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 930171003820 active site 930171003821 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 930171003822 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 930171003823 putative substrate binding region [chemical binding]; other site 930171003824 YCII-related domain; Region: YCII; pfam03795 930171003825 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 930171003826 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 930171003827 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 930171003828 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 930171003829 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930171003830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171003831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171003832 ABC-2 type transporter; Region: ABC2_membrane; cl17235 930171003833 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930171003834 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 930171003835 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930171003836 Walker A/P-loop; other site 930171003837 ATP binding site [chemical binding]; other site 930171003838 Q-loop/lid; other site 930171003839 ABC transporter signature motif; other site 930171003840 Walker B; other site 930171003841 D-loop; other site 930171003842 H-loop/switch region; other site 930171003843 prolyl-tRNA synthetase; Provisional; Region: PRK09194 930171003844 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 930171003845 dimer interface [polypeptide binding]; other site 930171003846 motif 1; other site 930171003847 active site 930171003848 motif 2; other site 930171003849 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 930171003850 putative deacylase active site [active] 930171003851 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 930171003852 active site 930171003853 motif 3; other site 930171003854 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 930171003855 anticodon binding site; other site 930171003856 hypothetical protein; Provisional; Region: PRK10621 930171003857 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930171003858 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 930171003859 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930171003860 catalytic residue [active] 930171003861 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 930171003862 CCC1-related family of proteins; Region: CCC1_like; cl00278 930171003863 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 930171003864 Sm and related proteins; Region: Sm_like; cl00259 930171003865 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 930171003866 putative oligomer interface [polypeptide binding]; other site 930171003867 putative RNA binding site [nucleotide binding]; other site 930171003868 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 930171003869 NusA N-terminal domain; Region: NusA_N; pfam08529 930171003870 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 930171003871 RNA binding site [nucleotide binding]; other site 930171003872 homodimer interface [polypeptide binding]; other site 930171003873 NusA-like KH domain; Region: KH_5; pfam13184 930171003874 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 930171003875 G-X-X-G motif; other site 930171003876 Protein of unknown function (DUF448); Region: DUF448; pfam04296 930171003877 putative RNA binding cleft [nucleotide binding]; other site 930171003878 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 930171003879 translation initiation factor IF-2; Region: IF-2; TIGR00487 930171003880 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 930171003881 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 930171003882 G1 box; other site 930171003883 putative GEF interaction site [polypeptide binding]; other site 930171003884 GTP/Mg2+ binding site [chemical binding]; other site 930171003885 Switch I region; other site 930171003886 G2 box; other site 930171003887 G3 box; other site 930171003888 Switch II region; other site 930171003889 G4 box; other site 930171003890 G5 box; other site 930171003891 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 930171003892 Translation-initiation factor 2; Region: IF-2; pfam11987 930171003893 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 930171003894 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 930171003895 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 930171003896 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 930171003897 nucleoside/Zn binding site; other site 930171003898 dimer interface [polypeptide binding]; other site 930171003899 catalytic motif [active] 930171003900 thioredoxin 2; Provisional; Region: PRK10996 930171003901 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930171003902 catalytic residues [active] 930171003903 aspartate aminotransferase; Provisional; Region: PRK06108 930171003904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171003905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171003906 homodimer interface [polypeptide binding]; other site 930171003907 catalytic residue [active] 930171003908 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 930171003909 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 930171003910 RNA binding site [nucleotide binding]; other site 930171003911 active site 930171003912 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 930171003913 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 930171003914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171003915 putative DNA binding site [nucleotide binding]; other site 930171003916 putative Zn2+ binding site [ion binding]; other site 930171003917 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 930171003918 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 930171003919 active site 930171003920 Riboflavin kinase; Region: Flavokinase; pfam01687 930171003921 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 930171003922 kynureninase; Region: kynureninase; TIGR01814 930171003923 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930171003924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930171003925 catalytic residue [active] 930171003926 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 930171003927 16S/18S rRNA binding site [nucleotide binding]; other site 930171003928 S13e-L30e interaction site [polypeptide binding]; other site 930171003929 25S rRNA binding site [nucleotide binding]; other site 930171003930 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 930171003931 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 930171003932 oligomer interface [polypeptide binding]; other site 930171003933 RNA binding site [nucleotide binding]; other site 930171003934 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 930171003935 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 930171003936 RNase E interface [polypeptide binding]; other site 930171003937 trimer interface [polypeptide binding]; other site 930171003938 active site 930171003939 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 930171003940 putative nucleic acid binding region [nucleotide binding]; other site 930171003941 G-X-X-G motif; other site 930171003942 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 930171003943 RNA binding site [nucleotide binding]; other site 930171003944 domain interface; other site 930171003945 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 930171003946 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 930171003947 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 930171003948 Domain of unknown function (DUF222); Region: DUF222; pfam02720 930171003949 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171003950 active site 930171003951 Ubiquitin-like proteins; Region: UBQ; cl00155 930171003952 charged pocket; other site 930171003953 hydrophobic patch; other site 930171003954 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 930171003955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930171003956 FeS/SAM binding site; other site 930171003957 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 930171003958 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 930171003959 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 930171003960 Moco binding site; other site 930171003961 metal coordination site [ion binding]; other site 930171003962 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 930171003963 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 930171003964 dimer interface [polypeptide binding]; other site 930171003965 putative functional site; other site 930171003966 putative MPT binding site; other site 930171003967 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 930171003968 trimer interface [polypeptide binding]; other site 930171003969 dimer interface [polypeptide binding]; other site 930171003970 putative active site [active] 930171003971 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 930171003972 MPT binding site; other site 930171003973 trimer interface [polypeptide binding]; other site 930171003974 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 930171003975 MoaE homodimer interface [polypeptide binding]; other site 930171003976 MoaD interaction [polypeptide binding]; other site 930171003977 active site residues [active] 930171003978 dihydrodipicolinate reductase; Provisional; Region: PRK00048 930171003979 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 930171003980 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 930171003981 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 930171003982 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 930171003983 dimer interface [polypeptide binding]; other site 930171003984 active site 930171003985 catalytic residue [active] 930171003986 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 930171003987 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 930171003988 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 930171003989 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 930171003990 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 930171003991 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930171003992 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 930171003993 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 930171003994 Competence-damaged protein; Region: CinA; pfam02464 930171003995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171003996 non-specific DNA binding site [nucleotide binding]; other site 930171003997 salt bridge; other site 930171003998 sequence-specific DNA binding site [nucleotide binding]; other site 930171003999 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930171004000 MarR family; Region: MarR_2; pfam12802 930171004001 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 930171004002 recombinase A; Provisional; Region: recA; PRK09354 930171004003 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 930171004004 hexamer interface [polypeptide binding]; other site 930171004005 Walker A motif; other site 930171004006 ATP binding site [chemical binding]; other site 930171004007 Walker B motif; other site 930171004008 recombination regulator RecX; Reviewed; Region: recX; PRK00117 930171004009 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 930171004010 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 930171004011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930171004012 FeS/SAM binding site; other site 930171004013 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 930171004014 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 930171004015 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 930171004016 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 930171004017 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 930171004018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171004019 S-adenosylmethionine binding site [chemical binding]; other site 930171004020 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 930171004021 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 930171004022 HflX GTPase family; Region: HflX; cd01878 930171004023 G1 box; other site 930171004024 GTP/Mg2+ binding site [chemical binding]; other site 930171004025 Switch I region; other site 930171004026 G2 box; other site 930171004027 G3 box; other site 930171004028 Switch II region; other site 930171004029 G4 box; other site 930171004030 G5 box; other site 930171004031 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 930171004032 DEAD/DEAH box helicase; Region: DEAD; pfam00270 930171004033 ATP binding site [chemical binding]; other site 930171004034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 930171004035 putative Mg++ binding site [ion binding]; other site 930171004036 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 930171004037 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 930171004038 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 930171004039 LexA repressor; Validated; Region: PRK00215 930171004040 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 930171004041 Catalytic site [active] 930171004042 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930171004043 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 930171004044 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171004045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171004046 homodimer interface [polypeptide binding]; other site 930171004047 catalytic residue [active] 930171004048 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 930171004049 putative active site pocket [active] 930171004050 4-fold oligomerization interface [polypeptide binding]; other site 930171004051 metal binding residues [ion binding]; metal-binding site 930171004052 3-fold/trimer interface [polypeptide binding]; other site 930171004053 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 930171004054 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 930171004055 putative active site [active] 930171004056 oxyanion strand; other site 930171004057 catalytic triad [active] 930171004058 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 930171004059 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 930171004060 catalytic residues [active] 930171004061 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171004062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171004063 translation initiation factor IF-3; Region: infC; TIGR00168 930171004064 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 930171004065 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 930171004066 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 930171004067 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 930171004068 23S rRNA binding site [nucleotide binding]; other site 930171004069 L21 binding site [polypeptide binding]; other site 930171004070 L13 binding site [polypeptide binding]; other site 930171004071 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 930171004072 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 930171004073 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 930171004074 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 930171004075 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 930171004076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171004077 putative substrate translocation pore; other site 930171004078 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 930171004079 active site 930171004080 8-oxo-dGMP binding site [chemical binding]; other site 930171004081 nudix motif; other site 930171004082 metal binding site [ion binding]; metal-binding site 930171004083 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930171004084 Radical SAM superfamily; Region: Radical_SAM; pfam04055 930171004085 FeS/SAM binding site; other site 930171004086 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 930171004087 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 930171004088 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 930171004089 dimer interface [polypeptide binding]; other site 930171004090 motif 1; other site 930171004091 active site 930171004092 motif 2; other site 930171004093 motif 3; other site 930171004094 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 930171004095 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 930171004096 putative tRNA-binding site [nucleotide binding]; other site 930171004097 B3/4 domain; Region: B3_4; pfam03483 930171004098 tRNA synthetase B5 domain; Region: B5; smart00874 930171004099 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 930171004100 dimer interface [polypeptide binding]; other site 930171004101 motif 1; other site 930171004102 motif 3; other site 930171004103 motif 2; other site 930171004104 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 930171004105 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 930171004106 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 930171004107 NADP binding site [chemical binding]; other site 930171004108 dimer interface [polypeptide binding]; other site 930171004109 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 930171004110 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 930171004111 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 930171004112 heterotetramer interface [polypeptide binding]; other site 930171004113 active site pocket [active] 930171004114 cleavage site 930171004115 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 930171004116 feedback inhibition sensing region; other site 930171004117 homohexameric interface [polypeptide binding]; other site 930171004118 nucleotide binding site [chemical binding]; other site 930171004119 N-acetyl-L-glutamate binding site [chemical binding]; other site 930171004120 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 930171004121 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930171004122 inhibitor-cofactor binding pocket; inhibition site 930171004123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171004124 catalytic residue [active] 930171004125 ornithine carbamoyltransferase; Provisional; Region: PRK00779 930171004126 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 930171004127 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 930171004128 arginine repressor; Provisional; Region: PRK03341 930171004129 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 930171004130 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 930171004131 argininosuccinate synthase; Provisional; Region: PRK13820 930171004132 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 930171004133 ANP binding site [chemical binding]; other site 930171004134 Substrate Binding Site II [chemical binding]; other site 930171004135 Substrate Binding Site I [chemical binding]; other site 930171004136 argininosuccinate lyase; Provisional; Region: PRK00855 930171004137 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 930171004138 active sites [active] 930171004139 tetramer interface [polypeptide binding]; other site 930171004140 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 930171004141 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 930171004142 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 930171004143 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 930171004144 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 930171004145 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 930171004146 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930171004147 DNA binding site [nucleotide binding] 930171004148 active site 930171004149 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 930171004150 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 930171004151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930171004152 AlkA N-terminal domain; Region: AlkA_N; pfam06029 930171004153 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 930171004154 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 930171004155 minor groove reading motif; other site 930171004156 helix-hairpin-helix signature motif; other site 930171004157 substrate binding pocket [chemical binding]; other site 930171004158 active site 930171004159 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 930171004160 active site 930171004161 DNA binding site [nucleotide binding] 930171004162 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 930171004163 Part of AAA domain; Region: AAA_19; pfam13245 930171004164 Family description; Region: UvrD_C_2; pfam13538 930171004165 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 930171004166 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 930171004167 active site 930171004168 HIGH motif; other site 930171004169 dimer interface [polypeptide binding]; other site 930171004170 KMSKS motif; other site 930171004171 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930171004172 RNA binding surface [nucleotide binding]; other site 930171004173 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 930171004174 Helix-turn-helix domain; Region: HTH_38; pfam13936 930171004175 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171004176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171004177 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171004178 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 930171004179 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 930171004180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171004181 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930171004182 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 930171004183 RNA binding surface [nucleotide binding]; other site 930171004184 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 930171004185 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 930171004186 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 930171004187 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 930171004188 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 930171004189 Walker A/P-loop; other site 930171004190 ATP binding site [chemical binding]; other site 930171004191 Q-loop/lid; other site 930171004192 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 930171004193 ABC transporter signature motif; other site 930171004194 Walker B; other site 930171004195 D-loop; other site 930171004196 H-loop/switch region; other site 930171004197 CTP synthetase; Validated; Region: pyrG; PRK05380 930171004198 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 930171004199 Catalytic site [active] 930171004200 active site 930171004201 UTP binding site [chemical binding]; other site 930171004202 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 930171004203 active site 930171004204 putative oxyanion hole; other site 930171004205 catalytic triad [active] 930171004206 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 930171004207 dimer interface [polypeptide binding]; other site 930171004208 ADP-ribose binding site [chemical binding]; other site 930171004209 active site 930171004210 nudix motif; other site 930171004211 metal binding site [ion binding]; metal-binding site 930171004212 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 930171004213 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 930171004214 active site 930171004215 Int/Topo IB signature motif; other site 930171004216 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 930171004217 nudix motif; other site 930171004218 citrate synthase; Provisional; Region: PRK14033 930171004219 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 930171004220 oxalacetate binding site [chemical binding]; other site 930171004221 citrylCoA binding site [chemical binding]; other site 930171004222 coenzyme A binding site [chemical binding]; other site 930171004223 catalytic triad [active] 930171004224 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 930171004225 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 930171004226 tetramer interface [polypeptide binding]; other site 930171004227 active site 930171004228 Mg2+/Mn2+ binding site [ion binding]; other site 930171004229 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 930171004230 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930171004231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171004232 DNA-binding site [nucleotide binding]; DNA binding site 930171004233 FCD domain; Region: FCD; pfam07729 930171004234 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 930171004235 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930171004236 acyl-activating enzyme (AAE) consensus motif; other site 930171004237 AMP binding site [chemical binding]; other site 930171004238 active site 930171004239 CoA binding site [chemical binding]; other site 930171004240 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 930171004241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171004242 active site 930171004243 phosphorylation site [posttranslational modification] 930171004244 intermolecular recognition site; other site 930171004245 dimerization interface [polypeptide binding]; other site 930171004246 HTH domain; Region: HTH_11; cl17392 930171004247 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 930171004248 PAS domain; Region: PAS; smart00091 930171004249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171004250 ATP binding site [chemical binding]; other site 930171004251 Mg2+ binding site [ion binding]; other site 930171004252 G-X-G motif; other site 930171004253 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 930171004254 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 930171004255 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 930171004256 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930171004257 P-loop; other site 930171004258 Magnesium ion binding site [ion binding]; other site 930171004259 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930171004260 Magnesium ion binding site [ion binding]; other site 930171004261 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 930171004262 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 930171004263 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 930171004264 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930171004265 RNA binding surface [nucleotide binding]; other site 930171004266 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 930171004267 active site 930171004268 prephenate dehydrogenase; Validated; Region: PRK06545 930171004269 prephenate dehydrogenase; Validated; Region: PRK08507 930171004270 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 930171004271 cytidylate kinase; Provisional; Region: cmk; PRK00023 930171004272 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 930171004273 CMP-binding site; other site 930171004274 The sites determining sugar specificity; other site 930171004275 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 930171004276 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 930171004277 putative acyl-acceptor binding pocket; other site 930171004278 GTP-binding protein Der; Reviewed; Region: PRK03003 930171004279 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 930171004280 G1 box; other site 930171004281 GTP/Mg2+ binding site [chemical binding]; other site 930171004282 Switch I region; other site 930171004283 G2 box; other site 930171004284 Switch II region; other site 930171004285 G3 box; other site 930171004286 G4 box; other site 930171004287 G5 box; other site 930171004288 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 930171004289 G1 box; other site 930171004290 GTP/Mg2+ binding site [chemical binding]; other site 930171004291 Switch I region; other site 930171004292 G2 box; other site 930171004293 G3 box; other site 930171004294 Switch II region; other site 930171004295 G4 box; other site 930171004296 G5 box; other site 930171004297 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 930171004298 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 930171004299 putative DNA binding site [nucleotide binding]; other site 930171004300 catalytic residue [active] 930171004301 putative H2TH interface [polypeptide binding]; other site 930171004302 putative catalytic residues [active] 930171004303 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 930171004304 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 930171004305 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 930171004306 lipoyl attachment site [posttranslational modification]; other site 930171004307 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 930171004308 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 930171004309 phosphopeptide binding site; other site 930171004310 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 930171004311 DNA binding residues [nucleotide binding] 930171004312 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930171004313 dimer interface [polypeptide binding]; other site 930171004314 Bifunctional nuclease; Region: DNase-RNase; pfam02577 930171004315 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 930171004316 DNA binding residues [nucleotide binding] 930171004317 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930171004318 putative dimer interface [polypeptide binding]; other site 930171004319 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 930171004320 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930171004321 Magnesium ion binding site [ion binding]; other site 930171004322 pyruvate carboxylase; Reviewed; Region: PRK12999 930171004323 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930171004324 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930171004325 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 930171004326 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 930171004327 active site 930171004328 catalytic residues [active] 930171004329 metal binding site [ion binding]; metal-binding site 930171004330 homodimer binding site [polypeptide binding]; other site 930171004331 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930171004332 carboxyltransferase (CT) interaction site; other site 930171004333 biotinylation site [posttranslational modification]; other site 930171004334 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 930171004335 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 930171004336 acyl-activating enzyme (AAE) consensus motif; other site 930171004337 putative AMP binding site [chemical binding]; other site 930171004338 putative active site [active] 930171004339 putative CoA binding site [chemical binding]; other site 930171004340 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 930171004341 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930171004342 nucleotide binding site [chemical binding]; other site 930171004343 Esterase/lipase [General function prediction only]; Region: COG1647 930171004344 Esterase/lipase [General function prediction only]; Region: COG1647 930171004345 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 930171004346 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 930171004347 putative acyl-acceptor binding pocket; other site 930171004348 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 930171004349 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930171004350 Catalytic domain of Protein Kinases; Region: PKc; cd00180 930171004351 active site 930171004352 ATP binding site [chemical binding]; other site 930171004353 substrate binding site [chemical binding]; other site 930171004354 activation loop (A-loop); other site 930171004355 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930171004356 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930171004357 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930171004358 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930171004359 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930171004360 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930171004361 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930171004362 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 930171004363 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 930171004364 N-acetyl-D-glucosamine binding site [chemical binding]; other site 930171004365 catalytic residue [active] 930171004366 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 930171004367 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 930171004368 substrate binding pocket [chemical binding]; other site 930171004369 chain length determination region; other site 930171004370 substrate-Mg2+ binding site; other site 930171004371 catalytic residues [active] 930171004372 aspartate-rich region 1; other site 930171004373 active site lid residues [active] 930171004374 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 930171004375 aspartate-rich region 2; other site 930171004376 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 930171004377 active site 930171004378 DNA polymerase IV; Validated; Region: PRK02406 930171004379 DNA binding site [nucleotide binding] 930171004380 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 930171004381 cell division protein MraZ; Reviewed; Region: PRK00326 930171004382 MraZ protein; Region: MraZ; pfam02381 930171004383 MraZ protein; Region: MraZ; pfam02381 930171004384 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 930171004385 MraW methylase family; Region: Methyltransf_5; cl17771 930171004386 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930171004387 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930171004388 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930171004389 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 930171004390 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930171004391 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930171004392 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 930171004393 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930171004394 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930171004395 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930171004396 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 930171004397 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 930171004398 Mg++ binding site [ion binding]; other site 930171004399 putative catalytic motif [active] 930171004400 putative substrate binding site [chemical binding]; other site 930171004401 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 930171004402 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930171004403 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930171004404 cell division protein FtsW; Region: ftsW; TIGR02614 930171004405 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 930171004406 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 930171004407 active site 930171004408 homodimer interface [polypeptide binding]; other site 930171004409 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 930171004410 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930171004411 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930171004412 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930171004413 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 930171004414 Cell division protein FtsQ; Region: FtsQ; pfam03799 930171004415 cell division protein FtsZ; Validated; Region: PRK09330 930171004416 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 930171004417 nucleotide binding site [chemical binding]; other site 930171004418 SulA interaction site; other site 930171004419 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 930171004420 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 930171004421 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 930171004422 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930171004423 catalytic residue [active] 930171004424 Protein of unknown function (DUF552); Region: DUF552; pfam04472 930171004425 Predicted integral membrane protein [Function unknown]; Region: COG0762 930171004426 DivIVA protein; Region: DivIVA; pfam05103 930171004427 DivIVA domain; Region: DivI1A_domain; TIGR03544 930171004428 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 930171004429 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 930171004430 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 930171004431 active site 930171004432 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 930171004433 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 930171004434 active site 930171004435 PHP Thumb interface [polypeptide binding]; other site 930171004436 metal binding site [ion binding]; metal-binding site 930171004437 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 930171004438 generic binding surface II; other site 930171004439 generic binding surface I; other site 930171004440 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 930171004441 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 930171004442 histidinol dehydrogenase; Region: hisD; TIGR00069 930171004443 NAD binding site [chemical binding]; other site 930171004444 dimerization interface [polypeptide binding]; other site 930171004445 product binding site; other site 930171004446 substrate binding site [chemical binding]; other site 930171004447 zinc binding site [ion binding]; other site 930171004448 catalytic residues [active] 930171004449 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 930171004450 ATP cone domain; Region: ATP-cone; pfam03477 930171004451 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930171004452 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930171004453 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 930171004454 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 930171004455 active site 930171004456 Sporulation related domain; Region: SPOR; cl10051 930171004457 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 930171004458 oligomerization interface [polypeptide binding]; other site 930171004459 active site 930171004460 metal binding site [ion binding]; metal-binding site 930171004461 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 930171004462 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 930171004463 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 930171004464 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 930171004465 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 930171004466 metal binding triad; other site 930171004467 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 930171004468 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 930171004469 metal binding triad; other site 930171004470 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 930171004471 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 930171004472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171004473 glutamine synthetase, type I; Region: GlnA; TIGR00653 930171004474 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 930171004475 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 930171004476 RDD family; Region: RDD; pfam06271 930171004477 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 930171004478 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 930171004479 lipoyl synthase; Provisional; Region: PRK05481 930171004480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930171004481 FeS/SAM binding site; other site 930171004482 lipoate-protein ligase B; Provisional; Region: PRK14345 930171004483 Catalytic domain of Protein Kinases; Region: PKc; cd00180 930171004484 active site 930171004485 ATP binding site [chemical binding]; other site 930171004486 substrate binding site [chemical binding]; other site 930171004487 activation loop (A-loop); other site 930171004488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171004489 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 930171004490 NAD(P) binding site [chemical binding]; other site 930171004491 active site 930171004492 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 930171004493 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 930171004494 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 930171004495 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 930171004496 protein binding site [polypeptide binding]; other site 930171004497 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 930171004498 Domain interface; other site 930171004499 Peptide binding site; other site 930171004500 Active site tetrad [active] 930171004501 OsmC-like protein; Region: OsmC; cl00767 930171004502 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930171004503 E3 interaction surface; other site 930171004504 lipoyl attachment site [posttranslational modification]; other site 930171004505 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930171004506 E3 interaction surface; other site 930171004507 lipoyl attachment site [posttranslational modification]; other site 930171004508 e3 binding domain; Region: E3_binding; pfam02817 930171004509 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 930171004510 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930171004511 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 930171004512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171004513 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930171004514 multifunctional aminopeptidase A; Provisional; Region: PRK00913 930171004515 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 930171004516 interface (dimer of trimers) [polypeptide binding]; other site 930171004517 Substrate-binding/catalytic site; other site 930171004518 Zn-binding sites [ion binding]; other site 930171004519 PAC2 family; Region: PAC2; pfam09754 930171004520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171004521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171004522 putative substrate translocation pore; other site 930171004523 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 930171004524 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 930171004525 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 930171004526 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930171004527 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 930171004528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930171004529 DNA binding residues [nucleotide binding] 930171004530 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 930171004531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171004532 ATP binding site [chemical binding]; other site 930171004533 Mg2+ binding site [ion binding]; other site 930171004534 G-X-G motif; other site 930171004535 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 930171004536 anchoring element; other site 930171004537 dimer interface [polypeptide binding]; other site 930171004538 ATP binding site [chemical binding]; other site 930171004539 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 930171004540 active site 930171004541 metal binding site [ion binding]; metal-binding site 930171004542 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 930171004543 Peptidase family M48; Region: Peptidase_M48; cl12018 930171004544 Penicillinase repressor; Region: Pencillinase_R; cl17580 930171004545 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 930171004546 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 930171004547 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 930171004548 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 930171004549 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 930171004550 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930171004551 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 930171004552 Walker A/P-loop; other site 930171004553 ATP binding site [chemical binding]; other site 930171004554 Q-loop/lid; other site 930171004555 ABC transporter signature motif; other site 930171004556 Walker B; other site 930171004557 D-loop; other site 930171004558 H-loop/switch region; other site 930171004559 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 930171004560 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 930171004561 Walker A/P-loop; other site 930171004562 ATP binding site [chemical binding]; other site 930171004563 Q-loop/lid; other site 930171004564 ABC transporter signature motif; other site 930171004565 Walker B; other site 930171004566 D-loop; other site 930171004567 H-loop/switch region; other site 930171004568 DinB superfamily; Region: DinB_2; pfam12867 930171004569 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 930171004570 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 930171004571 CAP-like domain; other site 930171004572 active site 930171004573 primary dimer interface [polypeptide binding]; other site 930171004574 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930171004575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930171004576 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 930171004577 CoA binding domain; Region: CoA_binding_2; pfam13380 930171004578 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 930171004579 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 930171004580 Uncharacterized conserved protein [Function unknown]; Region: COG3379 930171004581 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 930171004582 PglZ domain; Region: PglZ; pfam08665 930171004583 thymidine kinase; Provisional; Region: PRK04296 930171004584 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 930171004585 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 930171004586 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 930171004587 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 930171004588 trimer interface [polypeptide binding]; other site 930171004589 active site 930171004590 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 930171004591 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 930171004592 generic binding surface I; other site 930171004593 generic binding surface II; other site 930171004594 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 930171004595 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 930171004596 TrkA-N domain; Region: TrkA_N; pfam02254 930171004597 TrkA-C domain; Region: TrkA_C; pfam02080 930171004598 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 930171004599 TrkA-N domain; Region: TrkA_N; pfam02254 930171004600 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 930171004601 TRAM domain; Region: TRAM; pfam01938 930171004602 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 930171004603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171004604 S-adenosylmethionine binding site [chemical binding]; other site 930171004605 aconitate hydratase; Validated; Region: PRK09277 930171004606 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 930171004607 substrate binding site [chemical binding]; other site 930171004608 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 930171004609 ligand binding site [chemical binding]; other site 930171004610 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 930171004611 substrate binding site [chemical binding]; other site 930171004612 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 930171004613 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 930171004614 TPP-binding site [chemical binding]; other site 930171004615 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930171004616 PYR/PP interface [polypeptide binding]; other site 930171004617 dimer interface [polypeptide binding]; other site 930171004618 TPP binding site [chemical binding]; other site 930171004619 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930171004620 Protein of unknown function (DUF402); Region: DUF402; pfam04167 930171004621 Protein of unknown function (DUF402); Region: DUF402; cl00979 930171004622 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171004623 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171004624 active site 930171004625 catalytic tetrad [active] 930171004626 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 930171004627 active site 930171004628 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 930171004629 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930171004630 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930171004631 Walker A/P-loop; other site 930171004632 ATP binding site [chemical binding]; other site 930171004633 Q-loop/lid; other site 930171004634 ABC transporter signature motif; other site 930171004635 Walker B; other site 930171004636 D-loop; other site 930171004637 H-loop/switch region; other site 930171004638 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930171004639 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 930171004640 Walker A/P-loop; other site 930171004641 ATP binding site [chemical binding]; other site 930171004642 Q-loop/lid; other site 930171004643 ABC transporter signature motif; other site 930171004644 Walker B; other site 930171004645 D-loop; other site 930171004646 H-loop/switch region; other site 930171004647 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 930171004648 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930171004649 substrate binding site [chemical binding]; other site 930171004650 oxyanion hole (OAH) forming residues; other site 930171004651 trimer interface [polypeptide binding]; other site 930171004652 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 930171004653 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 930171004654 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 930171004655 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 930171004656 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930171004657 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 930171004658 dimer interface [polypeptide binding]; other site 930171004659 active site 930171004660 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 930171004661 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 930171004662 catalytic site [active] 930171004663 putative active site [active] 930171004664 putative substrate binding site [chemical binding]; other site 930171004665 Helicase and RNase D C-terminal; Region: HRDC; smart00341 930171004666 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 930171004667 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 930171004668 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 930171004669 tetramer interface [polypeptide binding]; other site 930171004670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171004671 catalytic residue [active] 930171004672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171004673 NAD(P) binding site [chemical binding]; other site 930171004674 active site 930171004675 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 930171004676 SelR domain; Region: SelR; pfam01641 930171004677 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171004678 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930171004679 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 930171004680 putative deacylase active site [active] 930171004681 Fe-S metabolism associated domain; Region: SufE; cl00951 930171004682 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 930171004683 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 930171004684 active site residue [active] 930171004685 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 930171004686 active site residue [active] 930171004687 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 930171004688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 930171004689 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 930171004690 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 930171004691 active site 930171004692 catalytic residues [active] 930171004693 metal binding site [ion binding]; metal-binding site 930171004694 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 930171004695 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 930171004696 putative active site [active] 930171004697 substrate binding site [chemical binding]; other site 930171004698 putative cosubstrate binding site; other site 930171004699 catalytic site [active] 930171004700 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 930171004701 substrate binding site [chemical binding]; other site 930171004702 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 930171004703 putative RNA binding site [nucleotide binding]; other site 930171004704 16S rRNA methyltransferase B; Provisional; Region: PRK14902 930171004705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171004706 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930171004707 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930171004708 substrate binding site [chemical binding]; other site 930171004709 hexamer interface [polypeptide binding]; other site 930171004710 metal binding site [ion binding]; metal-binding site 930171004711 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 930171004712 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 930171004713 catalytic motif [active] 930171004714 Zn binding site [ion binding]; other site 930171004715 RibD C-terminal domain; Region: RibD_C; cl17279 930171004716 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 930171004717 Lumazine binding domain; Region: Lum_binding; pfam00677 930171004718 Lumazine binding domain; Region: Lum_binding; pfam00677 930171004719 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 930171004720 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 930171004721 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 930171004722 dimerization interface [polypeptide binding]; other site 930171004723 active site 930171004724 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 930171004725 homopentamer interface [polypeptide binding]; other site 930171004726 active site 930171004727 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 930171004728 metal binding site [ion binding]; metal-binding site 930171004729 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 930171004730 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 930171004731 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 930171004732 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 930171004733 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 930171004734 substrate binding site [chemical binding]; other site 930171004735 glutamase interaction surface [polypeptide binding]; other site 930171004736 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 930171004737 anthranilate synthase component I; Provisional; Region: PRK13571 930171004738 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 930171004739 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 930171004740 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 930171004741 active site 930171004742 ribulose/triose binding site [chemical binding]; other site 930171004743 phosphate binding site [ion binding]; other site 930171004744 substrate (anthranilate) binding pocket [chemical binding]; other site 930171004745 product (indole) binding pocket [chemical binding]; other site 930171004746 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 930171004747 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 930171004748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171004749 catalytic residue [active] 930171004750 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 930171004751 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 930171004752 substrate binding site [chemical binding]; other site 930171004753 active site 930171004754 catalytic residues [active] 930171004755 heterodimer interface [polypeptide binding]; other site 930171004756 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 930171004757 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 930171004758 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 930171004759 active site 930171004760 dimer interface [polypeptide binding]; other site 930171004761 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 930171004762 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 930171004763 active site 930171004764 FMN binding site [chemical binding]; other site 930171004765 substrate binding site [chemical binding]; other site 930171004766 3Fe-4S cluster binding site [ion binding]; other site 930171004767 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 930171004768 domain interface; other site 930171004769 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 930171004770 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930171004771 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 930171004772 pyruvate kinase; Provisional; Region: PRK06247 930171004773 domain interfaces; other site 930171004774 active site 930171004775 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 930171004776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171004777 active site 930171004778 phosphorylation site [posttranslational modification] 930171004779 intermolecular recognition site; other site 930171004780 dimerization interface [polypeptide binding]; other site 930171004781 ANTAR domain; Region: ANTAR; pfam03861 930171004782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930171004783 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 930171004784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930171004785 dimer interface [polypeptide binding]; other site 930171004786 phosphorylation site [posttranslational modification] 930171004787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171004788 ATP binding site [chemical binding]; other site 930171004789 Mg2+ binding site [ion binding]; other site 930171004790 G-X-G motif; other site 930171004791 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930171004792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171004793 active site 930171004794 phosphorylation site [posttranslational modification] 930171004795 intermolecular recognition site; other site 930171004796 dimerization interface [polypeptide binding]; other site 930171004797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930171004798 DNA binding site [nucleotide binding] 930171004799 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 930171004800 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 930171004801 putative metal binding residues [ion binding]; other site 930171004802 signature motif; other site 930171004803 dimer interface [polypeptide binding]; other site 930171004804 active site 930171004805 polyP binding site; other site 930171004806 substrate binding site [chemical binding]; other site 930171004807 acceptor-phosphate pocket; other site 930171004808 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 930171004809 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 930171004810 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 930171004811 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 930171004812 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930171004813 hypothetical protein; Provisional; Region: PRK06126 930171004814 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 930171004815 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 930171004816 benzoate transport; Region: 2A0115; TIGR00895 930171004817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171004818 putative substrate translocation pore; other site 930171004819 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171004820 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 930171004821 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171004822 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930171004823 beta-galactosidase; Region: BGL; TIGR03356 930171004824 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 930171004825 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 930171004826 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930171004827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171004828 dimer interface [polypeptide binding]; other site 930171004829 conserved gate region; other site 930171004830 putative PBP binding loops; other site 930171004831 ABC-ATPase subunit interface; other site 930171004832 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930171004833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171004834 dimer interface [polypeptide binding]; other site 930171004835 conserved gate region; other site 930171004836 putative PBP binding loops; other site 930171004837 ABC-ATPase subunit interface; other site 930171004838 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 930171004839 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171004840 Walker A/P-loop; other site 930171004841 ATP binding site [chemical binding]; other site 930171004842 Q-loop/lid; other site 930171004843 ABC transporter signature motif; other site 930171004844 Walker B; other site 930171004845 D-loop; other site 930171004846 H-loop/switch region; other site 930171004847 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171004848 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 930171004849 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171004850 Walker A/P-loop; other site 930171004851 ATP binding site [chemical binding]; other site 930171004852 Q-loop/lid; other site 930171004853 ABC transporter signature motif; other site 930171004854 Walker B; other site 930171004855 D-loop; other site 930171004856 H-loop/switch region; other site 930171004857 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171004858 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 930171004859 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 930171004860 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 930171004861 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171004862 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 930171004863 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171004864 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 930171004865 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 930171004866 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 930171004867 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930171004868 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930171004869 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 930171004870 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930171004871 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930171004872 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 930171004873 substrate binding pocket [chemical binding]; other site 930171004874 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930171004875 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930171004876 Cupin domain; Region: Cupin_2; pfam07883 930171004877 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 930171004878 aspartate aminotransferase; Provisional; Region: PRK06107 930171004879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171004880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171004881 homodimer interface [polypeptide binding]; other site 930171004882 catalytic residue [active] 930171004883 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 930171004884 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 930171004885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171004886 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 930171004887 putative dimerization interface [polypeptide binding]; other site 930171004888 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 930171004889 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 930171004890 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 930171004891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171004892 Walker A/P-loop; other site 930171004893 ATP binding site [chemical binding]; other site 930171004894 Q-loop/lid; other site 930171004895 ABC transporter signature motif; other site 930171004896 Walker B; other site 930171004897 D-loop; other site 930171004898 H-loop/switch region; other site 930171004899 TOBE domain; Region: TOBE_2; pfam08402 930171004900 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 930171004901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171004902 dimer interface [polypeptide binding]; other site 930171004903 conserved gate region; other site 930171004904 putative PBP binding loops; other site 930171004905 ABC-ATPase subunit interface; other site 930171004906 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 930171004907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171004908 dimer interface [polypeptide binding]; other site 930171004909 conserved gate region; other site 930171004910 putative PBP binding loops; other site 930171004911 ABC-ATPase subunit interface; other site 930171004912 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 930171004913 putative active site [active] 930171004914 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 930171004915 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 930171004916 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 930171004917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171004918 metabolite-proton symporter; Region: 2A0106; TIGR00883 930171004919 putative substrate translocation pore; other site 930171004920 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 930171004921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171004922 NAD(P) binding site [chemical binding]; other site 930171004923 active site 930171004924 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 930171004925 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 930171004926 putative ligand binding site [chemical binding]; other site 930171004927 putative NAD binding site [chemical binding]; other site 930171004928 catalytic site [active] 930171004929 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 930171004930 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 930171004931 NADP binding site [chemical binding]; other site 930171004932 homodimer interface [polypeptide binding]; other site 930171004933 active site 930171004934 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 930171004935 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 930171004936 putative NAD(P) binding site [chemical binding]; other site 930171004937 catalytic Zn binding site [ion binding]; other site 930171004938 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 930171004939 ATP-binding site [chemical binding]; other site 930171004940 Gluconate-6-phosphate binding site [chemical binding]; other site 930171004941 Shikimate kinase; Region: SKI; pfam01202 930171004942 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 930171004943 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 930171004944 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 930171004945 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171004946 SnoaL-like domain; Region: SnoaL_2; pfam12680 930171004947 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171004948 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171004949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171004950 Coenzyme A binding pocket [chemical binding]; other site 930171004951 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171004952 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171004953 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171004954 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 930171004955 xylose isomerase; Provisional; Region: PRK12677 930171004956 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930171004957 extended (e) SDRs; Region: SDR_e; cd08946 930171004958 NAD(P) binding site [chemical binding]; other site 930171004959 active site 930171004960 substrate binding site [chemical binding]; other site 930171004961 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 930171004962 FAD binding domain; Region: FAD_binding_4; pfam01565 930171004963 Berberine and berberine like; Region: BBE; pfam08031 930171004964 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 930171004965 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 930171004966 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 930171004967 active site 930171004968 substrate binding site [chemical binding]; other site 930171004969 Mg2+ binding site [ion binding]; other site 930171004970 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 930171004971 active site 930171004972 catalytic triad [active] 930171004973 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 930171004974 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171004975 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171004976 active site 930171004977 catalytic tetrad [active] 930171004978 RibD C-terminal domain; Region: RibD_C; cl17279 930171004979 RibD C-terminal domain; Region: RibD_C; cl17279 930171004980 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 930171004981 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930171004982 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 930171004983 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171004984 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930171004985 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930171004986 active site 930171004987 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930171004988 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 930171004989 conserved hypothetical protein; Region: TIGR03843 930171004990 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930171004991 catalytic core [active] 930171004992 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171004993 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 930171004994 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171004995 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 930171004996 Cytochrome P450; Region: p450; cl12078 930171004997 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 930171004998 hypothetical protein; Provisional; Region: PRK08296 930171004999 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930171005000 short chain dehydrogenase; Provisional; Region: PRK12939 930171005001 classical (c) SDRs; Region: SDR_c; cd05233 930171005002 NAD(P) binding site [chemical binding]; other site 930171005003 active site 930171005004 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 930171005005 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 930171005006 catalytic loop [active] 930171005007 iron binding site [ion binding]; other site 930171005008 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 930171005009 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 930171005010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171005011 NAD binding site [chemical binding]; other site 930171005012 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930171005013 Zn2+ binding site [ion binding]; other site 930171005014 Mg2+ binding site [ion binding]; other site 930171005015 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 930171005016 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930171005017 NAD binding site [chemical binding]; other site 930171005018 catalytic residues [active] 930171005019 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 930171005020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 930171005021 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 930171005022 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 930171005023 metal ion-dependent adhesion site (MIDAS); other site 930171005024 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 930171005025 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 930171005026 active site 930171005027 metal binding site 1 [ion binding]; metal-binding site 930171005028 putative 5' ssDNA interaction site; other site 930171005029 metal binding site 3; metal-binding site 930171005030 metal binding site 2 [ion binding]; metal-binding site 930171005031 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 930171005032 putative DNA binding site [nucleotide binding]; other site 930171005033 putative metal binding site [ion binding]; other site 930171005034 FOG: CBS domain [General function prediction only]; Region: COG0517 930171005035 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 930171005036 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 930171005037 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 930171005038 putative Mg++ binding site [ion binding]; other site 930171005039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171005040 nucleotide binding region [chemical binding]; other site 930171005041 Helicase associated domain (HA2); Region: HA2; cl04503 930171005042 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 930171005043 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 930171005044 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 930171005045 nucleotide binding site [chemical binding]; other site 930171005046 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 930171005047 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171005048 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930171005049 dimer interface [polypeptide binding]; other site 930171005050 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 930171005051 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 930171005052 RibD C-terminal domain; Region: RibD_C; cl17279 930171005053 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 930171005054 CoenzymeA binding site [chemical binding]; other site 930171005055 subunit interaction site [polypeptide binding]; other site 930171005056 PHB binding site; other site 930171005057 DNA polymerase I; Provisional; Region: PRK05755 930171005058 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 930171005059 active site 930171005060 metal binding site 1 [ion binding]; metal-binding site 930171005061 putative 5' ssDNA interaction site; other site 930171005062 metal binding site 3; metal-binding site 930171005063 metal binding site 2 [ion binding]; metal-binding site 930171005064 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 930171005065 putative DNA binding site [nucleotide binding]; other site 930171005066 putative metal binding site [ion binding]; other site 930171005067 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 930171005068 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 930171005069 active site 930171005070 DNA binding site [nucleotide binding] 930171005071 catalytic site [active] 930171005072 amino acid transporter; Region: 2A0306; TIGR00909 930171005073 hypothetical protein; Provisional; Region: PRK01346 930171005074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930171005075 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 930171005076 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 930171005077 RNA binding site [nucleotide binding]; other site 930171005078 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 930171005079 RNA binding site [nucleotide binding]; other site 930171005080 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 930171005081 RNA binding site [nucleotide binding]; other site 930171005082 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 930171005083 RNA binding site [nucleotide binding]; other site 930171005084 domain interface; other site 930171005085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171005086 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930171005087 Coenzyme A binding pocket [chemical binding]; other site 930171005088 Uncharacterized conserved protein [Function unknown]; Region: COG1739 930171005089 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 930171005090 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 930171005091 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 930171005092 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 930171005093 CoA-binding site [chemical binding]; other site 930171005094 ATP-binding [chemical binding]; other site 930171005095 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 930171005096 excinuclease ABC subunit B; Provisional; Region: PRK05298 930171005097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171005098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171005099 nucleotide binding region [chemical binding]; other site 930171005100 ATP-binding site [chemical binding]; other site 930171005101 Ultra-violet resistance protein B; Region: UvrB; pfam12344 930171005102 UvrB/uvrC motif; Region: UVR; pfam02151 930171005103 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 930171005104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171005105 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 930171005106 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 930171005107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171005108 Coenzyme A binding pocket [chemical binding]; other site 930171005109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 930171005110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171005111 ATP binding site [chemical binding]; other site 930171005112 putative Mg++ binding site [ion binding]; other site 930171005113 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171005114 nucleotide binding region [chemical binding]; other site 930171005115 ATP-binding site [chemical binding]; other site 930171005116 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 930171005117 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 930171005118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171005119 S-adenosylmethionine binding site [chemical binding]; other site 930171005120 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930171005121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171005122 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930171005123 Walker A/P-loop; other site 930171005124 ATP binding site [chemical binding]; other site 930171005125 Q-loop/lid; other site 930171005126 ABC transporter signature motif; other site 930171005127 Walker B; other site 930171005128 D-loop; other site 930171005129 H-loop/switch region; other site 930171005130 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930171005131 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930171005132 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 930171005133 Walker A/P-loop; other site 930171005134 ATP binding site [chemical binding]; other site 930171005135 Q-loop/lid; other site 930171005136 ABC transporter signature motif; other site 930171005137 Walker B; other site 930171005138 D-loop; other site 930171005139 H-loop/switch region; other site 930171005140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171005141 DNA-binding site [nucleotide binding]; DNA binding site 930171005142 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 930171005143 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930171005144 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930171005145 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 930171005146 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 930171005147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171005148 motif II; other site 930171005149 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 930171005150 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 930171005151 putative acyl-acceptor binding pocket; other site 930171005152 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 930171005153 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 930171005154 GIY-YIG motif/motif A; other site 930171005155 active site 930171005156 catalytic site [active] 930171005157 putative DNA binding site [nucleotide binding]; other site 930171005158 metal binding site [ion binding]; metal-binding site 930171005159 UvrB/uvrC motif; Region: UVR; pfam02151 930171005160 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 930171005161 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 930171005162 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 930171005163 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 930171005164 putative substrate binding pocket [chemical binding]; other site 930171005165 dimer interface [polypeptide binding]; other site 930171005166 phosphate binding site [ion binding]; other site 930171005167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 930171005168 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 930171005169 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 930171005170 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 930171005171 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 930171005172 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 930171005173 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 930171005174 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 930171005175 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 930171005176 Phosphoglycerate kinase; Region: PGK; pfam00162 930171005177 substrate binding site [chemical binding]; other site 930171005178 hinge regions; other site 930171005179 ADP binding site [chemical binding]; other site 930171005180 catalytic site [active] 930171005181 triosephosphate isomerase; Provisional; Region: PRK14567 930171005182 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 930171005183 substrate binding site [chemical binding]; other site 930171005184 dimer interface [polypeptide binding]; other site 930171005185 catalytic triad [active] 930171005186 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 930171005187 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 930171005188 putative active site [active] 930171005189 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 930171005190 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 930171005191 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 930171005192 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 930171005193 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 930171005194 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 930171005195 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 930171005196 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 930171005197 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 930171005198 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 930171005199 putative active site [active] 930171005200 catalytic residue [active] 930171005201 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 930171005202 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 930171005203 TPP-binding site [chemical binding]; other site 930171005204 dimer interface [polypeptide binding]; other site 930171005205 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930171005206 PYR/PP interface [polypeptide binding]; other site 930171005207 dimer interface [polypeptide binding]; other site 930171005208 TPP binding site [chemical binding]; other site 930171005209 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930171005210 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 930171005211 UbiA prenyltransferase family; Region: UbiA; pfam01040 930171005212 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 930171005213 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 930171005214 ABC-2 type transporter; Region: ABC2_membrane; cl17235 930171005215 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930171005216 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930171005217 Walker A/P-loop; other site 930171005218 ATP binding site [chemical binding]; other site 930171005219 Q-loop/lid; other site 930171005220 ABC transporter signature motif; other site 930171005221 Walker B; other site 930171005222 D-loop; other site 930171005223 H-loop/switch region; other site 930171005224 Predicted transcriptional regulator [Transcription]; Region: COG2345 930171005225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171005226 putative DNA binding site [nucleotide binding]; other site 930171005227 putative Zn2+ binding site [ion binding]; other site 930171005228 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 930171005229 FeS assembly protein SufB; Region: sufB; TIGR01980 930171005230 FeS assembly protein SufD; Region: sufD; TIGR01981 930171005231 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 930171005232 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 930171005233 [2Fe-2S] cluster binding site [ion binding]; other site 930171005234 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 930171005235 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 930171005236 Walker A/P-loop; other site 930171005237 ATP binding site [chemical binding]; other site 930171005238 Q-loop/lid; other site 930171005239 ABC transporter signature motif; other site 930171005240 Walker B; other site 930171005241 D-loop; other site 930171005242 H-loop/switch region; other site 930171005243 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 930171005244 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 930171005245 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 930171005246 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930171005247 AMP binding site [chemical binding]; other site 930171005248 active site 930171005249 acyl-activating enzyme (AAE) consensus motif; other site 930171005250 CoA binding site [chemical binding]; other site 930171005251 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930171005252 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 930171005253 dimer interface [polypeptide binding]; other site 930171005254 active site 930171005255 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 930171005256 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930171005257 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930171005258 Walker A/P-loop; other site 930171005259 ATP binding site [chemical binding]; other site 930171005260 Q-loop/lid; other site 930171005261 ABC transporter signature motif; other site 930171005262 Walker B; other site 930171005263 D-loop; other site 930171005264 H-loop/switch region; other site 930171005265 BioY family; Region: BioY; pfam02632 930171005266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171005267 S-adenosylmethionine binding site [chemical binding]; other site 930171005268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 930171005269 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 930171005270 putative dimer interface [polypeptide binding]; other site 930171005271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171005272 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 930171005273 putative dimer interface [polypeptide binding]; other site 930171005274 catalytic triad [active] 930171005275 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 930171005276 active site 930171005277 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930171005278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171005279 Walker A/P-loop; other site 930171005280 ATP binding site [chemical binding]; other site 930171005281 Q-loop/lid; other site 930171005282 ABC transporter signature motif; other site 930171005283 Walker B; other site 930171005284 D-loop; other site 930171005285 H-loop/switch region; other site 930171005286 ABC transporter; Region: ABC_tran_2; pfam12848 930171005287 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930171005288 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 930171005289 putative deacylase active site [active] 930171005290 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 930171005291 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 930171005292 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 930171005293 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 930171005294 NAD(P) binding site [chemical binding]; other site 930171005295 homotetramer interface [polypeptide binding]; other site 930171005296 homodimer interface [polypeptide binding]; other site 930171005297 active site 930171005298 short chain dehydrogenase; Provisional; Region: PRK07806 930171005299 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 930171005300 NAD(P) binding site [chemical binding]; other site 930171005301 active site 930171005302 phosphoserine phosphatase SerB; Region: serB; TIGR00338 930171005303 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930171005304 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 930171005305 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930171005306 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 930171005307 Walker A/P-loop; other site 930171005308 ATP binding site [chemical binding]; other site 930171005309 Q-loop/lid; other site 930171005310 ABC transporter signature motif; other site 930171005311 Walker B; other site 930171005312 D-loop; other site 930171005313 H-loop/switch region; other site 930171005314 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930171005315 hypothetical protein; Provisional; Region: PRK10621 930171005316 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 930171005317 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 930171005318 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 930171005319 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 930171005320 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 930171005321 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 930171005322 Zn binding site [ion binding]; other site 930171005323 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 930171005324 Uncharacterized conserved protein [Function unknown]; Region: COG2308 930171005325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 930171005326 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 930171005327 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 930171005328 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 930171005329 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 930171005330 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 930171005331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171005332 NAD(P) binding site [chemical binding]; other site 930171005333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171005334 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 930171005335 active site 930171005336 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 930171005337 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 930171005338 ligand binding site; other site 930171005339 oligomer interface; other site 930171005340 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 930171005341 sulfate 1 binding site; other site 930171005342 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 930171005343 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 930171005344 acyl-coenzyme A oxidase; Region: PLN02636 930171005345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930171005346 active site 930171005347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171005348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171005349 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 930171005350 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930171005351 dimer interface [polypeptide binding]; other site 930171005352 active site 930171005353 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 930171005354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171005355 NAD(P) binding site [chemical binding]; other site 930171005356 active site 930171005357 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 930171005358 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 930171005359 active site 930171005360 catalytic site [active] 930171005361 cysteate synthase; Region: cysteate_syn; TIGR03844 930171005362 Beta-lactamase; Region: Beta-lactamase; pfam00144 930171005363 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930171005364 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 930171005365 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 930171005366 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 930171005367 putative dimer interface [polypeptide binding]; other site 930171005368 N-terminal domain interface [polypeptide binding]; other site 930171005369 putative substrate binding pocket (H-site) [chemical binding]; other site 930171005370 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 930171005371 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 930171005372 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 930171005373 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 930171005374 putative active site [active] 930171005375 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 930171005376 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 930171005377 putative active site [active] 930171005378 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 930171005379 active site 930171005380 catalytic triad [active] 930171005381 oxyanion hole [active] 930171005382 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 930171005383 Protein of unknown function (DUF805); Region: DUF805; pfam05656 930171005384 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 930171005385 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 930171005386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930171005387 Histidine kinase; Region: HisKA_3; pfam07730 930171005388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171005389 ATP binding site [chemical binding]; other site 930171005390 Mg2+ binding site [ion binding]; other site 930171005391 G-X-G motif; other site 930171005392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 930171005393 Homeodomain-like domain; Region: HTH_23; pfam13384 930171005394 Winged helix-turn helix; Region: HTH_29; pfam13551 930171005395 Homeodomain-like domain; Region: HTH_32; pfam13565 930171005396 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 930171005397 Integrase core domain; Region: rve; pfam00665 930171005398 Integrase core domain; Region: rve_3; pfam13683 930171005399 hypothetical protein; Provisional; Region: PRK07906 930171005400 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 930171005401 putative metal binding site [ion binding]; other site 930171005402 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 930171005403 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 930171005404 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930171005405 active site 930171005406 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171005407 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171005408 active site 930171005409 catalytic tetrad [active] 930171005410 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 930171005411 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930171005412 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 930171005413 active site 930171005414 HIGH motif; other site 930171005415 nucleotide binding site [chemical binding]; other site 930171005416 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930171005417 active site 930171005418 KMSKS motif; other site 930171005419 PAC2 family; Region: PAC2; pfam09754 930171005420 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 930171005421 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930171005422 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 930171005423 active site 930171005424 Peptidase family M50; Region: Peptidase_M50; pfam02163 930171005425 putative substrate binding region [chemical binding]; other site 930171005426 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 930171005427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171005428 S-adenosylmethionine binding site [chemical binding]; other site 930171005429 proteasome ATPase; Region: pup_AAA; TIGR03689 930171005430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171005431 Walker A motif; other site 930171005432 ATP binding site [chemical binding]; other site 930171005433 Walker B motif; other site 930171005434 arginine finger; other site 930171005435 Pup-ligase protein; Region: Pup_ligase; cl15463 930171005436 Pup-like protein; Region: Pup; pfam05639 930171005437 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 930171005438 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 930171005439 active site 930171005440 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 930171005441 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 930171005442 active site 930171005443 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 930171005444 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 930171005445 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 930171005446 WYL domain; Region: WYL; pfam13280 930171005447 Predicted transcriptional regulator [Transcription]; Region: COG2378 930171005448 WYL domain; Region: WYL; pfam13280 930171005449 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 930171005450 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 930171005451 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 930171005452 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171005453 ATP binding site [chemical binding]; other site 930171005454 putative Mg++ binding site [ion binding]; other site 930171005455 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171005456 nucleotide binding region [chemical binding]; other site 930171005457 ATP-binding site [chemical binding]; other site 930171005458 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 930171005459 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 930171005460 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930171005461 active site 930171005462 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 930171005463 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 930171005464 Ligand binding site; other site 930171005465 Putative Catalytic site; other site 930171005466 DXD motif; other site 930171005467 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 930171005468 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 930171005469 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 930171005470 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 930171005471 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 930171005472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171005473 S-adenosylmethionine binding site [chemical binding]; other site 930171005474 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 930171005475 active site 930171005476 catalytic residues [active] 930171005477 metal binding site [ion binding]; metal-binding site 930171005478 SnoaL-like domain; Region: SnoaL_2; pfam12680 930171005479 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 930171005480 FAD binding domain; Region: FAD_binding_3; pfam01494 930171005481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171005482 S-adenosylmethionine binding site [chemical binding]; other site 930171005483 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 930171005484 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 930171005485 malonyl-CoA binding site [chemical binding]; other site 930171005486 dimer interface [polypeptide binding]; other site 930171005487 active site 930171005488 product binding site; other site 930171005489 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 930171005490 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 930171005491 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 930171005492 active site 930171005493 catalytic residues [active] 930171005494 DNA binding site [nucleotide binding] 930171005495 Int/Topo IB signature motif; other site 930171005496 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 930171005497 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930171005498 META domain; Region: META; pfam03724 930171005499 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 930171005500 Bacterial transcriptional activator domain; Region: BTAD; smart01043 930171005501 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930171005502 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 930171005503 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 930171005504 active site 930171005505 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930171005506 dimer interface [polypeptide binding]; other site 930171005507 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 930171005508 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930171005509 AsnC family; Region: AsnC_trans_reg; pfam01037 930171005510 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 930171005511 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 930171005512 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 930171005513 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 930171005514 Subunit I/III interface [polypeptide binding]; other site 930171005515 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 930171005516 Cytochrome c; Region: Cytochrom_C; pfam00034 930171005517 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 930171005518 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 930171005519 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 930171005520 iron-sulfur cluster [ion binding]; other site 930171005521 [2Fe-2S] cluster binding site [ion binding]; other site 930171005522 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 930171005523 interchain domain interface [polypeptide binding]; other site 930171005524 heme bL binding site [chemical binding]; other site 930171005525 intrachain domain interface; other site 930171005526 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 930171005527 heme bH binding site [chemical binding]; other site 930171005528 Qo binding site; other site 930171005529 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930171005530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171005531 DNA-binding site [nucleotide binding]; DNA binding site 930171005532 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930171005533 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 930171005534 dimerization domain swap beta strand [polypeptide binding]; other site 930171005535 regulatory protein interface [polypeptide binding]; other site 930171005536 active site 930171005537 regulatory phosphorylation site [posttranslational modification]; other site 930171005538 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 930171005539 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 930171005540 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 930171005541 D-pathway; other site 930171005542 Putative ubiquinol binding site [chemical binding]; other site 930171005543 Low-spin heme (heme b) binding site [chemical binding]; other site 930171005544 Putative water exit pathway; other site 930171005545 Binuclear center (heme o3/CuB) [ion binding]; other site 930171005546 K-pathway; other site 930171005547 Putative proton exit pathway; other site 930171005548 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 930171005549 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 930171005550 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 930171005551 hypothetical protein; Provisional; Region: PRK07907 930171005552 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 930171005553 active site 930171005554 metal binding site [ion binding]; metal-binding site 930171005555 dimer interface [polypeptide binding]; other site 930171005556 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 930171005557 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 930171005558 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 930171005559 quinone interaction residues [chemical binding]; other site 930171005560 active site 930171005561 catalytic residues [active] 930171005562 FMN binding site [chemical binding]; other site 930171005563 substrate binding site [chemical binding]; other site 930171005564 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930171005565 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 930171005566 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930171005567 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930171005568 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 930171005569 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 930171005570 catalytic residue [active] 930171005571 putative FPP diphosphate binding site; other site 930171005572 putative FPP binding hydrophobic cleft; other site 930171005573 dimer interface [polypeptide binding]; other site 930171005574 putative IPP diphosphate binding site; other site 930171005575 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 930171005576 Recombination protein O N terminal; Region: RecO_N; pfam11967 930171005577 Recombination protein O C terminal; Region: RecO_C; pfam02565 930171005578 2-isopropylmalate synthase; Validated; Region: PRK03739 930171005579 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 930171005580 active site 930171005581 catalytic residues [active] 930171005582 metal binding site [ion binding]; metal-binding site 930171005583 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 930171005584 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 930171005585 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 930171005586 active site 930171005587 Zn binding site [ion binding]; other site 930171005588 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 930171005589 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 930171005590 GTPase Era; Reviewed; Region: era; PRK00089 930171005591 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 930171005592 G1 box; other site 930171005593 GTP/Mg2+ binding site [chemical binding]; other site 930171005594 Switch I region; other site 930171005595 G2 box; other site 930171005596 Switch II region; other site 930171005597 G3 box; other site 930171005598 G4 box; other site 930171005599 G5 box; other site 930171005600 KH domain; Region: KH_2; pfam07650 930171005601 Domain of unknown function DUF21; Region: DUF21; pfam01595 930171005602 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 930171005603 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930171005604 Transporter associated domain; Region: CorC_HlyC; smart01091 930171005605 metal-binding heat shock protein; Provisional; Region: PRK00016 930171005606 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 930171005607 PhoH-like protein; Region: PhoH; pfam02562 930171005608 Sporulation and spore germination; Region: Germane; pfam10646 930171005609 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 930171005610 RNA methyltransferase, RsmE family; Region: TIGR00046 930171005611 chaperone protein DnaJ; Provisional; Region: PRK14278 930171005612 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 930171005613 HSP70 interaction site [polypeptide binding]; other site 930171005614 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 930171005615 Zn binding sites [ion binding]; other site 930171005616 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 930171005617 dimer interface [polypeptide binding]; other site 930171005618 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 930171005619 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 930171005620 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 930171005621 Tic20-like protein; Region: Tic20; pfam09685 930171005622 coproporphyrinogen III oxidase; Validated; Region: PRK05628 930171005623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930171005624 FeS/SAM binding site; other site 930171005625 GTP-binding protein LepA; Provisional; Region: PRK05433 930171005626 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 930171005627 G1 box; other site 930171005628 putative GEF interaction site [polypeptide binding]; other site 930171005629 GTP/Mg2+ binding site [chemical binding]; other site 930171005630 Switch I region; other site 930171005631 G2 box; other site 930171005632 G3 box; other site 930171005633 Switch II region; other site 930171005634 G4 box; other site 930171005635 G5 box; other site 930171005636 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 930171005637 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 930171005638 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 930171005639 PemK-like protein; Region: PemK; pfam02452 930171005640 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 930171005641 hypothetical protein; Reviewed; Region: PRK07914 930171005642 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 930171005643 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 930171005644 Competence protein; Region: Competence; pfam03772 930171005645 comEA protein; Region: comE; TIGR01259 930171005646 EDD domain protein, DegV family; Region: DegV; TIGR00762 930171005647 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 930171005648 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 930171005649 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 930171005650 HIGH motif; other site 930171005651 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 930171005652 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930171005653 active site 930171005654 KMSKS motif; other site 930171005655 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 930171005656 tRNA binding surface [nucleotide binding]; other site 930171005657 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 930171005658 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930171005659 glycerol kinase; Provisional; Region: glpK; PRK00047 930171005660 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 930171005661 N- and C-terminal domain interface [polypeptide binding]; other site 930171005662 active site 930171005663 MgATP binding site [chemical binding]; other site 930171005664 catalytic site [active] 930171005665 metal binding site [ion binding]; metal-binding site 930171005666 putative homotetramer interface [polypeptide binding]; other site 930171005667 glycerol binding site [chemical binding]; other site 930171005668 homodimer interface [polypeptide binding]; other site 930171005669 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 930171005670 amphipathic channel; other site 930171005671 Asn-Pro-Ala signature motifs; other site 930171005672 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 930171005673 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 930171005674 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 930171005675 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171005676 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171005677 active site 930171005678 catalytic tetrad [active] 930171005679 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930171005680 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 930171005681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930171005682 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 930171005683 primosome assembly protein PriA; Provisional; Region: PRK14873 930171005684 S-adenosylmethionine synthetase; Validated; Region: PRK05250 930171005685 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 930171005686 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 930171005687 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 930171005688 Flavoprotein; Region: Flavoprotein; pfam02441 930171005689 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 930171005690 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 930171005691 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 930171005692 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 930171005693 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 930171005694 catalytic site [active] 930171005695 G-X2-G-X-G-K; other site 930171005696 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 930171005697 active site 930171005698 dimer interface [polypeptide binding]; other site 930171005699 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 930171005700 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930171005701 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930171005702 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 930171005703 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930171005704 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930171005705 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 930171005706 IMP binding site; other site 930171005707 dimer interface [polypeptide binding]; other site 930171005708 interdomain contacts; other site 930171005709 partial ornithine binding site; other site 930171005710 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 930171005711 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 930171005712 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 930171005713 catalytic site [active] 930171005714 subunit interface [polypeptide binding]; other site 930171005715 dihydroorotase; Validated; Region: pyrC; PRK09357 930171005716 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930171005717 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 930171005718 active site 930171005719 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 930171005720 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 930171005721 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 930171005722 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 930171005723 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930171005724 active site 930171005725 Protease prsW family; Region: PrsW-protease; pfam13367 930171005726 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 930171005727 substrate binding site [chemical binding]; other site 930171005728 dimer interface [polypeptide binding]; other site 930171005729 catalytic triad [active] 930171005730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171005731 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171005732 putative substrate translocation pore; other site 930171005733 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 930171005734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171005735 NAD(P) binding site [chemical binding]; other site 930171005736 active site 930171005737 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 930171005738 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 930171005739 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 930171005740 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 930171005741 dihydroxyacetone kinase; Provisional; Region: PRK14479 930171005742 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 930171005743 DAK2 domain; Region: Dak2; pfam02734 930171005744 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 930171005745 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930171005746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171005747 DNA-binding site [nucleotide binding]; DNA binding site 930171005748 FCD domain; Region: FCD; pfam07729 930171005749 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 930171005750 putative RNA binding site [nucleotide binding]; other site 930171005751 elongation factor P; Validated; Region: PRK00529 930171005752 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 930171005753 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 930171005754 RNA binding site [nucleotide binding]; other site 930171005755 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 930171005756 RNA binding site [nucleotide binding]; other site 930171005757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 930171005758 binding surface 930171005759 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930171005760 TPR motif; other site 930171005761 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 930171005762 dimer interface [polypeptide binding]; other site 930171005763 active site 930171005764 metal binding site [ion binding]; metal-binding site 930171005765 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 930171005766 Shikimate kinase; Region: SKI; pfam01202 930171005767 ADP binding site [chemical binding]; other site 930171005768 magnesium binding site [ion binding]; other site 930171005769 putative shikimate binding site; other site 930171005770 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 930171005771 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 930171005772 Tetramer interface [polypeptide binding]; other site 930171005773 active site 930171005774 FMN-binding site [chemical binding]; other site 930171005775 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 930171005776 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 930171005777 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 930171005778 shikimate binding site; other site 930171005779 NAD(P) binding site [chemical binding]; other site 930171005780 YceG-like family; Region: YceG; pfam02618 930171005781 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 930171005782 dimerization interface [polypeptide binding]; other site 930171005783 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 930171005784 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 930171005785 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 930171005786 motif 1; other site 930171005787 active site 930171005788 motif 2; other site 930171005789 motif 3; other site 930171005790 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 930171005791 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 930171005792 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 930171005793 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930171005794 RNA binding surface [nucleotide binding]; other site 930171005795 recombination factor protein RarA; Reviewed; Region: PRK13342 930171005796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171005797 Walker A motif; other site 930171005798 ATP binding site [chemical binding]; other site 930171005799 Walker B motif; other site 930171005800 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 930171005801 peptide chain release factor 1; Provisional; Region: PRK04011 930171005802 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930171005803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171005804 Coenzyme A binding pocket [chemical binding]; other site 930171005805 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 930171005806 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 930171005807 dimer interface [polypeptide binding]; other site 930171005808 anticodon binding site; other site 930171005809 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 930171005810 homodimer interface [polypeptide binding]; other site 930171005811 motif 1; other site 930171005812 active site 930171005813 motif 2; other site 930171005814 GAD domain; Region: GAD; pfam02938 930171005815 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 930171005816 active site 930171005817 motif 3; other site 930171005818 amino acid transporter; Region: 2A0306; TIGR00909 930171005819 histidyl-tRNA synthetase; Region: hisS; TIGR00442 930171005820 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 930171005821 dimer interface [polypeptide binding]; other site 930171005822 motif 1; other site 930171005823 active site 930171005824 motif 2; other site 930171005825 motif 3; other site 930171005826 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 930171005827 anticodon binding site; other site 930171005828 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 930171005829 active site 930171005830 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 930171005831 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 930171005832 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 930171005833 HD domain; Region: HD_4; pfam13328 930171005834 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 930171005835 synthetase active site [active] 930171005836 NTP binding site [chemical binding]; other site 930171005837 metal binding site [ion binding]; metal-binding site 930171005838 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 930171005839 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 930171005840 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 930171005841 Protein export membrane protein; Region: SecD_SecF; cl14618 930171005842 protein-export membrane protein SecD; Region: secD; TIGR01129 930171005843 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 930171005844 Preprotein translocase subunit; Region: YajC; pfam02699 930171005845 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 930171005846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171005847 Walker A motif; other site 930171005848 ATP binding site [chemical binding]; other site 930171005849 Walker B motif; other site 930171005850 arginine finger; other site 930171005851 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 930171005852 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 930171005853 RuvA N terminal domain; Region: RuvA_N; pfam01330 930171005854 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 930171005855 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 930171005856 active site 930171005857 putative DNA-binding cleft [nucleotide binding]; other site 930171005858 dimer interface [polypeptide binding]; other site 930171005859 hypothetical protein; Validated; Region: PRK00110 930171005860 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 930171005861 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 930171005862 predicted active site [active] 930171005863 catalytic triad [active] 930171005864 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930171005865 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 930171005866 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 930171005867 catalytic triad [active] 930171005868 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 930171005869 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 930171005870 putative active site [active] 930171005871 putative metal binding site [ion binding]; other site 930171005872 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 930171005873 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 930171005874 active site 930171005875 Zn binding site [ion binding]; other site 930171005876 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 930171005877 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 930171005878 active site 930171005879 multimer interface [polypeptide binding]; other site 930171005880 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 930171005881 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 930171005882 nucleotide binding site/active site [active] 930171005883 HIT family signature motif; other site 930171005884 catalytic residue [active] 930171005885 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 930171005886 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 930171005887 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 930171005888 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 930171005889 active site 930171005890 dimer interface [polypeptide binding]; other site 930171005891 motif 1; other site 930171005892 motif 2; other site 930171005893 motif 3; other site 930171005894 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 930171005895 anticodon binding site; other site 930171005896 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 930171005897 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 930171005898 active site 930171005899 PHP Thumb interface [polypeptide binding]; other site 930171005900 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 930171005901 generic binding surface I; other site 930171005902 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12813 930171005903 Chorismate mutase type II; Region: CM_2; smart00830 930171005904 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171005905 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 930171005906 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 930171005907 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 930171005908 catalytic residues [active] 930171005909 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 930171005910 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 930171005911 ABC1 family; Region: ABC1; cl17513 930171005912 Predicted transcriptional regulators [Transcription]; Region: COG1695 930171005913 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930171005914 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 930171005915 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 930171005916 putative metal binding site [ion binding]; other site 930171005917 NUDIX domain; Region: NUDIX; pfam00293 930171005918 nudix motif; other site 930171005919 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 930171005920 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 930171005921 active site 930171005922 metal binding site [ion binding]; metal-binding site 930171005923 homotetramer interface [polypeptide binding]; other site 930171005924 oxidoreductase; Provisional; Region: PRK06128 930171005925 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 930171005926 NAD binding site [chemical binding]; other site 930171005927 metal binding site [ion binding]; metal-binding site 930171005928 active site 930171005929 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 930171005930 A new structural DNA glycosylase; Region: AlkD_like; cl11434 930171005931 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 930171005932 ydaO-yuaA leader 930171005933 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930171005934 hypothetical protein; Validated; Region: PRK00029 930171005935 Uncharacterized conserved protein [Function unknown]; Region: COG0397 930171005936 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 930171005937 ribonuclease Z; Reviewed; Region: PRK00055 930171005938 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 930171005939 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 930171005940 Short C-terminal domain; Region: SHOCT; pfam09851 930171005941 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171005942 Ligand Binding Site [chemical binding]; other site 930171005943 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171005944 Ligand Binding Site [chemical binding]; other site 930171005945 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 930171005946 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171005947 Ligand Binding Site [chemical binding]; other site 930171005948 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930171005949 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 930171005950 NodB motif; other site 930171005951 active site 930171005952 catalytic site [active] 930171005953 metal binding site [ion binding]; metal-binding site 930171005954 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 930171005955 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 930171005956 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930171005957 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 930171005958 Soluble P-type ATPase [General function prediction only]; Region: COG4087 930171005959 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930171005960 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 930171005961 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171005962 Ligand Binding Site [chemical binding]; other site 930171005963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171005964 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171005965 active site 930171005966 phosphorylation site [posttranslational modification] 930171005967 intermolecular recognition site; other site 930171005968 dimerization interface [polypeptide binding]; other site 930171005969 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171005970 DNA binding residues [nucleotide binding] 930171005971 dimerization interface [polypeptide binding]; other site 930171005972 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 930171005973 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 930171005974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930171005975 Histidine kinase; Region: HisKA_3; pfam07730 930171005976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171005977 ATP binding site [chemical binding]; other site 930171005978 Mg2+ binding site [ion binding]; other site 930171005979 G-X-G motif; other site 930171005980 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 930171005981 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171005982 Ligand Binding Site [chemical binding]; other site 930171005983 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171005984 Ligand Binding Site [chemical binding]; other site 930171005985 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 930171005986 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930171005987 Soluble P-type ATPase [General function prediction only]; Region: COG4087 930171005988 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 930171005989 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 930171005990 putative NAD(P) binding site [chemical binding]; other site 930171005991 putative substrate binding site [chemical binding]; other site 930171005992 catalytic Zn binding site [ion binding]; other site 930171005993 structural Zn binding site [ion binding]; other site 930171005994 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 930171005995 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 930171005996 putative dimer interface [polypeptide binding]; other site 930171005997 phosphoenolpyruvate synthase; Validated; Region: PRK06464 930171005998 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 930171005999 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 930171006000 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 930171006001 golgi membrane calcium-translocating P-type ATPase; Region: ATPase-IIA2_Ca; TIGR01522 930171006002 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 930171006003 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930171006004 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 930171006005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171006006 motif II; other site 930171006007 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930171006008 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171006009 Ligand Binding Site [chemical binding]; other site 930171006010 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 930171006011 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930171006012 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 930171006013 Flavodoxin; Region: Flavodoxin_1; pfam00258 930171006014 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 930171006015 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 930171006016 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 930171006017 S-layer protein, MJ0822 family; Region: S_layer_MJ; TIGR01564 930171006018 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 930171006019 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930171006020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171006021 Walker A/P-loop; other site 930171006022 ATP binding site [chemical binding]; other site 930171006023 Q-loop/lid; other site 930171006024 ABC transporter signature motif; other site 930171006025 Walker B; other site 930171006026 D-loop; other site 930171006027 H-loop/switch region; other site 930171006028 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 930171006029 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930171006030 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930171006031 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 930171006032 classical (c) SDRs; Region: SDR_c; cd05233 930171006033 NAD(P) binding site [chemical binding]; other site 930171006034 active site 930171006035 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171006036 Ligand Binding Site [chemical binding]; other site 930171006037 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171006038 Ligand Binding Site [chemical binding]; other site 930171006039 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 930171006040 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930171006041 catalytic Zn binding site [ion binding]; other site 930171006042 structural Zn binding site [ion binding]; other site 930171006043 NAD(P) binding site [chemical binding]; other site 930171006044 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171006045 active site 930171006046 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 930171006047 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171006048 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171006049 DNA binding site [nucleotide binding] 930171006050 domain linker motif; other site 930171006051 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 930171006052 putative dimerization interface [polypeptide binding]; other site 930171006053 putative ligand binding site [chemical binding]; other site 930171006054 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171006055 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171006056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171006057 dimer interface [polypeptide binding]; other site 930171006058 conserved gate region; other site 930171006059 putative PBP binding loops; other site 930171006060 ABC-ATPase subunit interface; other site 930171006061 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171006062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171006063 dimer interface [polypeptide binding]; other site 930171006064 conserved gate region; other site 930171006065 putative PBP binding loops; other site 930171006066 ABC-ATPase subunit interface; other site 930171006067 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 930171006068 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 930171006069 substrate binding [chemical binding]; other site 930171006070 active site 930171006071 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 930171006072 Domain of unknown function (DUF222); Region: DUF222; pfam02720 930171006073 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171006074 active site 930171006075 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 930171006076 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 930171006077 metal ion-dependent adhesion site (MIDAS); other site 930171006078 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 930171006079 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 930171006080 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930171006081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171006082 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 930171006083 FOG: CBS domain [General function prediction only]; Region: COG0517 930171006084 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 930171006085 stage V sporulation protein K; Region: spore_V_K; TIGR02881 930171006086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171006087 Walker A motif; other site 930171006088 ATP binding site [chemical binding]; other site 930171006089 Walker B motif; other site 930171006090 arginine finger; other site 930171006091 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 930171006092 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 930171006093 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 930171006094 dimer interface [polypeptide binding]; other site 930171006095 putative radical transfer pathway; other site 930171006096 diiron center [ion binding]; other site 930171006097 tyrosyl radical; other site 930171006098 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 930171006099 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 930171006100 Class I ribonucleotide reductase; Region: RNR_I; cd01679 930171006101 active site 930171006102 dimer interface [polypeptide binding]; other site 930171006103 catalytic residues [active] 930171006104 effector binding site; other site 930171006105 R2 peptide binding site; other site 930171006106 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 930171006107 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 930171006108 catalytic residues [active] 930171006109 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 930171006110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171006111 S-adenosylmethionine binding site [chemical binding]; other site 930171006112 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 930171006113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930171006114 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 930171006115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930171006116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171006117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 930171006118 dimerization interface [polypeptide binding]; other site 930171006119 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 930171006120 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 930171006121 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 930171006122 THF binding site; other site 930171006123 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 930171006124 substrate binding site [chemical binding]; other site 930171006125 THF binding site; other site 930171006126 zinc-binding site [ion binding]; other site 930171006127 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 930171006128 FAD binding site [chemical binding]; other site 930171006129 von Willebrand factor type A domain; Region: VWA_2; pfam13519 930171006130 metal ion-dependent adhesion site (MIDAS); other site 930171006131 metal ion-dependent adhesion site (MIDAS); other site 930171006132 von Willebrand factor type A domain; Region: VWA_2; pfam13519 930171006133 Protein of unknown function DUF58; Region: DUF58; pfam01882 930171006134 MoxR-like ATPases [General function prediction only]; Region: COG0714 930171006135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171006136 Walker A motif; other site 930171006137 ATP binding site [chemical binding]; other site 930171006138 Walker B motif; other site 930171006139 arginine finger; other site 930171006140 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 930171006141 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930171006142 active site 930171006143 metal binding site [ion binding]; metal-binding site 930171006144 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171006145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171006146 dimer interface [polypeptide binding]; other site 930171006147 conserved gate region; other site 930171006148 putative PBP binding loops; other site 930171006149 ABC-ATPase subunit interface; other site 930171006150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171006151 dimer interface [polypeptide binding]; other site 930171006152 conserved gate region; other site 930171006153 putative PBP binding loops; other site 930171006154 ABC-ATPase subunit interface; other site 930171006155 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171006156 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171006157 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 930171006158 non-specific DNA interactions [nucleotide binding]; other site 930171006159 DNA binding site [nucleotide binding] 930171006160 sequence specific DNA binding site [nucleotide binding]; other site 930171006161 putative cAMP binding site [chemical binding]; other site 930171006162 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930171006163 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930171006164 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 930171006165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171006166 S-adenosylmethionine binding site [chemical binding]; other site 930171006167 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 930171006168 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930171006169 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 930171006170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171006171 S-adenosylmethionine binding site [chemical binding]; other site 930171006172 DNA protecting protein DprA; Region: dprA; TIGR00732 930171006173 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 930171006174 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930171006175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171006176 salt bridge; other site 930171006177 non-specific DNA binding site [nucleotide binding]; other site 930171006178 sequence-specific DNA binding site [nucleotide binding]; other site 930171006179 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 930171006180 metal binding triad [ion binding]; metal-binding site 930171006181 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 930171006182 ThiF family; Region: ThiF; pfam00899 930171006183 ATP binding site [chemical binding]; other site 930171006184 substrate interface [chemical binding]; other site 930171006185 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 930171006186 TIR domain; Region: TIR_2; pfam13676 930171006187 TrwC relaxase; Region: TrwC; pfam08751 930171006188 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 930171006189 AAA domain; Region: AAA_30; pfam13604 930171006190 AAA domain; Region: AAA_22; pfam13401 930171006191 short chain dehydrogenase; Provisional; Region: PRK06172 930171006192 classical (c) SDRs; Region: SDR_c; cd05233 930171006193 NAD(P) binding site [chemical binding]; other site 930171006194 active site 930171006195 HTH-like domain; Region: HTH_21; pfam13276 930171006196 Integrase core domain; Region: rve; pfam00665 930171006197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930171006198 Transposase; Region: HTH_Tnp_1; pfam01527 930171006199 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 930171006200 nudix motif; other site 930171006201 Integrase core domain; Region: rve; pfam00665 930171006202 Integrase core domain; Region: rve_3; pfam13683 930171006203 Transposase; Region: HTH_Tnp_1; pfam01527 930171006204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930171006205 putative transposase OrfB; Reviewed; Region: PHA02517 930171006206 HTH-like domain; Region: HTH_21; pfam13276 930171006207 Integrase core domain; Region: rve; pfam00665 930171006208 Integrase core domain; Region: rve_3; pfam13683 930171006209 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 930171006210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930171006211 DNA binding residues [nucleotide binding] 930171006212 Transposase; Region: HTH_Tnp_1; pfam01527 930171006213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930171006214 putative transposase OrfB; Reviewed; Region: PHA02517 930171006215 HTH-like domain; Region: HTH_21; pfam13276 930171006216 Integrase core domain; Region: rve; pfam00665 930171006217 Integrase core domain; Region: rve_3; pfam13683 930171006218 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 930171006219 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 930171006220 active site 930171006221 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 930171006222 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930171006223 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 930171006224 benzoate transport; Region: 2A0115; TIGR00895 930171006225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171006226 putative substrate translocation pore; other site 930171006227 Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952 930171006228 putative active site [active] 930171006229 catalytic residue [active] 930171006230 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 930171006231 Cupin domain; Region: Cupin_2; pfam07883 930171006232 Cupin domain; Region: Cupin_2; pfam07883 930171006233 Integrase core domain; Region: rve; pfam00665 930171006234 Integrase core domain; Region: rve_3; pfam13683 930171006235 Integrase core domain; Region: rve; pfam00665 930171006236 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 930171006237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171006238 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171006239 Transposase; Region: HTH_Tnp_1; pfam01527 930171006240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930171006241 putative transposase OrfB; Reviewed; Region: PHA02517 930171006242 HTH-like domain; Region: HTH_21; pfam13276 930171006243 Integrase core domain; Region: rve; pfam00665 930171006244 Integrase core domain; Region: rve_3; pfam13683 930171006245 Helix-turn-helix domain; Region: HTH_38; pfam13936 930171006246 putative transposase OrfB; Reviewed; Region: PHA02517 930171006247 HTH-like domain; Region: HTH_21; pfam13276 930171006248 Integrase core domain; Region: rve; pfam00665 930171006249 Integrase core domain; Region: rve_3; pfam13683 930171006250 Transposase; Region: HTH_Tnp_1; pfam01527 930171006251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930171006252 Integrase core domain; Region: rve_3; cl15866 930171006253 Integrase core domain; Region: rve; pfam00665 930171006254 Integrase core domain; Region: rve_3; pfam13683 930171006255 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 930171006256 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171006257 putative active site [active] 930171006258 putative metal binding site [ion binding]; other site 930171006259 Predicted membrane protein [Function unknown]; Region: COG2259 930171006260 Predicted transcriptional regulators [Transcription]; Region: COG1733 930171006261 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 930171006262 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930171006263 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 930171006264 active site 930171006265 DNA binding site [nucleotide binding] 930171006266 Int/Topo IB signature motif; other site 930171006267 potential frameshift: common BLAST hit: gi|315446114|ref|YP_004078993.1| site-specific recombinase XerD 930171006268 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 930171006269 DNA binding site [nucleotide binding] 930171006270 Int/Topo IB signature motif; other site 930171006271 active site 930171006272 catalytic residues [active] 930171006273 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171006274 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171006275 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 930171006276 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 930171006277 DNA binding domain, excisionase family; Region: excise; TIGR01764 930171006278 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171006279 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930171006280 Domain of unknown function (DUF955); Region: DUF955; pfam06114 930171006281 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 930171006282 polymerase nucleotide-binding site; other site 930171006283 DNA-binding residues [nucleotide binding]; DNA binding site 930171006284 nucleotide binding site [chemical binding]; other site 930171006285 primase nucleotide-binding site [nucleotide binding]; other site 930171006286 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 930171006287 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 930171006288 Helix-turn-helix domain; Region: HTH_38; pfam13936 930171006289 ParB-like nuclease domain; Region: ParB; smart00470 930171006290 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930171006291 Peptidase family M23; Region: Peptidase_M23; pfam01551 930171006292 AAA-like domain; Region: AAA_10; pfam12846 930171006293 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 930171006294 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 930171006295 Walker A motif; other site 930171006296 ATP binding site [chemical binding]; other site 930171006297 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 930171006298 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930171006299 dimer interface [polypeptide binding]; other site 930171006300 ssDNA binding site [nucleotide binding]; other site 930171006301 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930171006302 Oligomerisation domain; Region: Oligomerisation; pfam02410 930171006303 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 930171006304 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 930171006305 active site 930171006306 (T/H)XGH motif; other site 930171006307 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 930171006308 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 930171006309 putative catalytic cysteine [active] 930171006310 gamma-glutamyl kinase; Provisional; Region: PRK05429 930171006311 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 930171006312 nucleotide binding site [chemical binding]; other site 930171006313 homotetrameric interface [polypeptide binding]; other site 930171006314 putative phosphate binding site [ion binding]; other site 930171006315 putative allosteric binding site; other site 930171006316 PUA domain; Region: PUA; pfam01472 930171006317 GTPase CgtA; Reviewed; Region: obgE; PRK12296 930171006318 GTP1/OBG; Region: GTP1_OBG; pfam01018 930171006319 Obg GTPase; Region: Obg; cd01898 930171006320 G1 box; other site 930171006321 GTP/Mg2+ binding site [chemical binding]; other site 930171006322 Switch I region; other site 930171006323 G2 box; other site 930171006324 G3 box; other site 930171006325 Switch II region; other site 930171006326 G4 box; other site 930171006327 G5 box; other site 930171006328 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 930171006329 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 930171006330 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 930171006331 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 930171006332 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 930171006333 dimer interface [polypeptide binding]; other site 930171006334 substrate binding site [chemical binding]; other site 930171006335 ATP binding site [chemical binding]; other site 930171006336 Putative transcription activator [Transcription]; Region: TenA; COG0819 930171006337 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 930171006338 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 930171006339 homodimer interface [polypeptide binding]; other site 930171006340 oligonucleotide binding site [chemical binding]; other site 930171006341 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 930171006342 putative active site [active] 930171006343 redox center [active] 930171006344 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 930171006345 active site 930171006346 multimer interface [polypeptide binding]; other site 930171006347 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 930171006348 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 930171006349 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930171006350 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930171006351 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 930171006352 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 930171006353 HIGH motif; other site 930171006354 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 930171006355 active site 930171006356 KMSKS motif; other site 930171006357 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 930171006358 tRNA binding surface [nucleotide binding]; other site 930171006359 anticodon binding site; other site 930171006360 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 930171006361 putative catalytic site [active] 930171006362 putative phosphate binding site [ion binding]; other site 930171006363 putative metal binding site [ion binding]; other site 930171006364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171006365 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 930171006366 NAD(P) binding site [chemical binding]; other site 930171006367 active site 930171006368 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 930171006369 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930171006370 active site 930171006371 HIGH motif; other site 930171006372 nucleotide binding site [chemical binding]; other site 930171006373 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930171006374 active site 930171006375 KMSKS motif; other site 930171006376 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 930171006377 tRNA binding surface [nucleotide binding]; other site 930171006378 anticodon binding site; other site 930171006379 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 930171006380 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 930171006381 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 930171006382 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 930171006383 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 930171006384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171006385 Walker A motif; other site 930171006386 ATP binding site [chemical binding]; other site 930171006387 Walker B motif; other site 930171006388 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 930171006389 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 930171006390 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 930171006391 oligomer interface [polypeptide binding]; other site 930171006392 active site residues [active] 930171006393 Clp protease; Region: CLP_protease; pfam00574 930171006394 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 930171006395 oligomer interface [polypeptide binding]; other site 930171006396 active site residues [active] 930171006397 trigger factor; Provisional; Region: tig; PRK01490 930171006398 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 930171006399 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 930171006400 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 930171006401 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 930171006402 putative DNA binding site [nucleotide binding]; other site 930171006403 catalytic residue [active] 930171006404 putative H2TH interface [polypeptide binding]; other site 930171006405 putative catalytic residues [active] 930171006406 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 930171006407 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 930171006408 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 930171006409 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 930171006410 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 930171006411 Zn binding site [ion binding]; other site 930171006412 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 930171006413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171006414 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 930171006415 NAD(P) binding site [chemical binding]; other site 930171006416 active site 930171006417 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 930171006418 Mechanosensitive ion channel; Region: MS_channel; pfam00924 930171006419 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 930171006420 apolar tunnel; other site 930171006421 heme binding site [chemical binding]; other site 930171006422 dimerization interface [polypeptide binding]; other site 930171006423 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 930171006424 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 930171006425 active site 930171006426 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 930171006427 catalytic triad [active] 930171006428 dimer interface [polypeptide binding]; other site 930171006429 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 930171006430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171006431 Walker A/P-loop; other site 930171006432 ATP binding site [chemical binding]; other site 930171006433 Q-loop/lid; other site 930171006434 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930171006435 ABC transporter signature motif; other site 930171006436 Walker B; other site 930171006437 D-loop; other site 930171006438 ABC transporter; Region: ABC_tran_2; pfam12848 930171006439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930171006440 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930171006441 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930171006442 dimer interface [polypeptide binding]; other site 930171006443 ssDNA binding site [nucleotide binding]; other site 930171006444 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930171006445 Homeodomain-like domain; Region: HTH_23; pfam13384 930171006446 Winged helix-turn helix; Region: HTH_29; pfam13551 930171006447 Homeodomain-like domain; Region: HTH_32; pfam13565 930171006448 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 930171006449 Integrase core domain; Region: rve; pfam00665 930171006450 Integrase core domain; Region: rve_3; pfam13683 930171006451 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930171006452 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930171006453 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 930171006454 xylose isomerase; Provisional; Region: PRK12677 930171006455 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930171006456 nucleotide binding site [chemical binding]; other site 930171006457 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930171006458 Protein of unknown function (DUF993); Region: DUF993; pfam06187 930171006459 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171006460 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171006461 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171006462 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171006463 DNA binding site [nucleotide binding] 930171006464 domain linker motif; other site 930171006465 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171006466 dimerization interface [polypeptide binding]; other site 930171006467 ligand binding site [chemical binding]; other site 930171006468 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 930171006469 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930171006470 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 930171006471 active site 930171006472 catalytic residues [active] 930171006473 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 930171006474 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 930171006475 active site 930171006476 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 930171006477 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 930171006478 putative active site [active] 930171006479 putative substrate binding site [chemical binding]; other site 930171006480 dimer interface [polypeptide binding]; other site 930171006481 catalytic site [active] 930171006482 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 930171006483 active site 930171006484 catalytic residues [active] 930171006485 metal binding site [ion binding]; metal-binding site 930171006486 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 930171006487 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 930171006488 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 930171006489 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 930171006490 TspO/MBR family; Region: TspO_MBR; pfam03073 930171006491 hypothetical protein; Validated; Region: PRK02101 930171006492 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 930171006493 Putative zinc ribbon domain; Region: DUF164; pfam02591 930171006494 Uncharacterized conserved protein [Function unknown]; Region: COG0327 930171006495 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 930171006496 methionine sulfoxide reductase A; Provisional; Region: PRK14054 930171006497 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 930171006498 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 930171006499 dimer interface [polypeptide binding]; other site 930171006500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171006501 catalytic residue [active] 930171006502 serine O-acetyltransferase; Region: cysE; TIGR01172 930171006503 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 930171006504 trimer interface [polypeptide binding]; other site 930171006505 active site 930171006506 substrate binding site [chemical binding]; other site 930171006507 CoA binding site [chemical binding]; other site 930171006508 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930171006509 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 930171006510 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 930171006511 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930171006512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171006513 DNA-binding site [nucleotide binding]; DNA binding site 930171006514 FCD domain; Region: FCD; pfam07729 930171006515 NAD-dependent deacetylase; Provisional; Region: PRK05333 930171006516 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 930171006517 NAD+ binding site [chemical binding]; other site 930171006518 substrate binding site [chemical binding]; other site 930171006519 Zn binding site [ion binding]; other site 930171006520 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 930171006521 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 930171006522 dimer interface [polypeptide binding]; other site 930171006523 catalytic triad [active] 930171006524 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 930171006525 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 930171006526 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 930171006527 dimer interface [polypeptide binding]; other site 930171006528 TPP-binding site [chemical binding]; other site 930171006529 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930171006530 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 930171006531 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 930171006532 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 930171006533 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 930171006534 dimer interface [polypeptide binding]; other site 930171006535 active site 930171006536 CoA binding pocket [chemical binding]; other site 930171006537 acyl carrier protein; Provisional; Region: acpP; PRK00982 930171006538 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 930171006539 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 930171006540 dimer interface [polypeptide binding]; other site 930171006541 active site 930171006542 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 930171006543 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 930171006544 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930171006545 active site 930171006546 DNA binding site [nucleotide binding] 930171006547 Int/Topo IB signature motif; other site 930171006548 DNA protecting protein DprA; Region: dprA; TIGR00732 930171006549 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 930171006550 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 930171006551 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 930171006552 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 930171006553 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 930171006554 hypothetical protein; Reviewed; Region: PRK12497 930171006555 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 930171006556 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 930171006557 RNA/DNA hybrid binding site [nucleotide binding]; other site 930171006558 active site 930171006559 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 930171006560 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930171006561 Catalytic site [active] 930171006562 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 930171006563 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930171006564 Catalytic site [active] 930171006565 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 930171006566 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 930171006567 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 930171006568 RimM N-terminal domain; Region: RimM; pfam01782 930171006569 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 930171006570 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 930171006571 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 930171006572 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 930171006573 putative metal binding site [ion binding]; other site 930171006574 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930171006575 active site 930171006576 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 930171006577 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930171006578 active site 930171006579 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 930171006580 ThiC-associated domain; Region: ThiC-associated; pfam13667 930171006581 ThiC family; Region: ThiC; pfam01964 930171006582 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171006583 signal recognition particle protein; Provisional; Region: PRK10867 930171006584 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 930171006585 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 930171006586 P loop; other site 930171006587 GTP binding site [chemical binding]; other site 930171006588 Signal peptide binding domain; Region: SRP_SPB; pfam02978 930171006589 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 930171006590 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 930171006591 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 930171006592 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 930171006593 Nitrogen regulatory protein P-II; Region: P-II; smart00938 930171006594 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 930171006595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171006596 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171006597 putative substrate translocation pore; other site 930171006598 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 930171006599 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 930171006600 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930171006601 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 930171006602 AAA domain; Region: AAA_23; pfam13476 930171006603 Walker A/P-loop; other site 930171006604 ATP binding site [chemical binding]; other site 930171006605 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 930171006606 ABC transporter signature motif; other site 930171006607 Walker B; other site 930171006608 D-loop; other site 930171006609 H-loop/switch region; other site 930171006610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171006611 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171006612 putative substrate translocation pore; other site 930171006613 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 930171006614 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 930171006615 DNA binding site [nucleotide binding] 930171006616 catalytic residue [active] 930171006617 H2TH interface [polypeptide binding]; other site 930171006618 putative catalytic residues [active] 930171006619 turnover-facilitating residue; other site 930171006620 intercalation triad [nucleotide binding]; other site 930171006621 8OG recognition residue [nucleotide binding]; other site 930171006622 putative reading head residues; other site 930171006623 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 930171006624 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 930171006625 ribonuclease III; Reviewed; Region: rnc; PRK00102 930171006626 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 930171006627 dimerization interface [polypeptide binding]; other site 930171006628 active site 930171006629 metal binding site [ion binding]; metal-binding site 930171006630 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 930171006631 dsRNA binding site [nucleotide binding]; other site 930171006632 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 930171006633 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 930171006634 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 930171006635 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 930171006636 active site 930171006637 (T/H)XGH motif; other site 930171006638 aminotransferase; Validated; Region: PRK07777 930171006639 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171006640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171006641 homodimer interface [polypeptide binding]; other site 930171006642 catalytic residue [active] 930171006643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171006644 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 930171006645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171006646 S-adenosylmethionine binding site [chemical binding]; other site 930171006647 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 930171006648 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 930171006649 generic binding surface II; other site 930171006650 ssDNA binding site; other site 930171006651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171006652 ATP binding site [chemical binding]; other site 930171006653 putative Mg++ binding site [ion binding]; other site 930171006654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171006655 nucleotide binding region [chemical binding]; other site 930171006656 ATP-binding site [chemical binding]; other site 930171006657 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 930171006658 DAK2 domain; Region: Dak2; pfam02734 930171006659 thiamine monophosphate kinase; Provisional; Region: PRK05731 930171006660 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 930171006661 ATP binding site [chemical binding]; other site 930171006662 dimerization interface [polypeptide binding]; other site 930171006663 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 930171006664 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 930171006665 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 930171006666 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 930171006667 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 930171006668 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 930171006669 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 930171006670 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 930171006671 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 930171006672 putative acyl-acceptor binding pocket; other site 930171006673 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 930171006674 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 930171006675 hinge; other site 930171006676 active site 930171006677 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 930171006678 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 930171006679 substrate binding site [chemical binding]; other site 930171006680 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 930171006681 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 930171006682 substrate binding site [chemical binding]; other site 930171006683 ligand binding site [chemical binding]; other site 930171006684 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 930171006685 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171006686 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171006687 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 930171006688 YfjP GTPase; Region: YfjP; cd11383 930171006689 G1 box; other site 930171006690 GTP/Mg2+ binding site [chemical binding]; other site 930171006691 Switch I region; other site 930171006692 G2 box; other site 930171006693 Switch II region; other site 930171006694 G3 box; other site 930171006695 G4 box; other site 930171006696 G5 box; other site 930171006697 Dynamin family; Region: Dynamin_N; pfam00350 930171006698 Protein of unknown function, DUF258; Region: DUF258; pfam03193 930171006699 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 930171006700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171006701 motif II; other site 930171006702 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 930171006703 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 930171006704 HIGH motif; other site 930171006705 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 930171006706 active site 930171006707 KMSKS motif; other site 930171006708 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 930171006709 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 930171006710 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930171006711 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930171006712 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 930171006713 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 930171006714 homodimer interface [polypeptide binding]; other site 930171006715 substrate-cofactor binding pocket; other site 930171006716 catalytic residue [active] 930171006717 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 930171006718 tartrate dehydrogenase; Region: TTC; TIGR02089 930171006719 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 930171006720 active site 930171006721 catalytic site [active] 930171006722 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 930171006723 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 930171006724 active site 930171006725 HIGH motif; other site 930171006726 KMSKS motif; other site 930171006727 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 930171006728 tRNA binding surface [nucleotide binding]; other site 930171006729 anticodon binding site; other site 930171006730 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930171006731 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930171006732 Walker A/P-loop; other site 930171006733 ATP binding site [chemical binding]; other site 930171006734 Q-loop/lid; other site 930171006735 ABC transporter signature motif; other site 930171006736 Walker B; other site 930171006737 D-loop; other site 930171006738 H-loop/switch region; other site 930171006739 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 930171006740 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 930171006741 ligand binding site [chemical binding]; other site 930171006742 NAD binding site [chemical binding]; other site 930171006743 dimerization interface [polypeptide binding]; other site 930171006744 catalytic site [active] 930171006745 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 930171006746 putative L-serine binding site [chemical binding]; other site 930171006747 ketol-acid reductoisomerase; Provisional; Region: PRK05479 930171006748 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 930171006749 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 930171006750 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 930171006751 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 930171006752 putative valine binding site [chemical binding]; other site 930171006753 dimer interface [polypeptide binding]; other site 930171006754 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 930171006755 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 930171006756 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930171006757 PYR/PP interface [polypeptide binding]; other site 930171006758 dimer interface [polypeptide binding]; other site 930171006759 TPP binding site [chemical binding]; other site 930171006760 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930171006761 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 930171006762 TPP-binding site [chemical binding]; other site 930171006763 dimer interface [polypeptide binding]; other site 930171006764 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 930171006765 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 930171006766 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 930171006767 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 930171006768 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930171006769 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 930171006770 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 930171006771 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 930171006772 catalytic triad [active] 930171006773 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 930171006774 Fasciclin domain; Region: Fasciclin; pfam02469 930171006775 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 930171006776 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 930171006777 peptide binding site [polypeptide binding]; other site 930171006778 malate:quinone oxidoreductase; Validated; Region: PRK05257 930171006779 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 930171006780 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 930171006781 Protein export membrane protein; Region: SecD_SecF; cl14618 930171006782 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 930171006783 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 930171006784 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 930171006785 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930171006786 MarR family; Region: MarR_2; cl17246 930171006787 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 930171006788 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 930171006789 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 930171006790 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 930171006791 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 930171006792 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930171006793 catalytic residue [active] 930171006794 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 930171006795 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 930171006796 dimerization interface [polypeptide binding]; other site 930171006797 active site 930171006798 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 930171006799 L-aspartate oxidase; Provisional; Region: PRK06175 930171006800 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 930171006801 quinolinate synthetase; Provisional; Region: PRK09375 930171006802 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 930171006803 nudix motif; other site 930171006804 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 930171006805 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 930171006806 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 930171006807 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171006808 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930171006809 active site 930171006810 metabolite-proton symporter; Region: 2A0106; TIGR00883 930171006811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171006812 putative substrate translocation pore; other site 930171006813 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171006814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171006815 putative DNA binding site [nucleotide binding]; other site 930171006816 putative Zn2+ binding site [ion binding]; other site 930171006817 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171006818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171006819 AAA domain; Region: AAA_23; pfam13476 930171006820 Walker A/P-loop; other site 930171006821 ATP binding site [chemical binding]; other site 930171006822 Q-loop/lid; other site 930171006823 ABC transporter signature motif; other site 930171006824 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 930171006825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171006826 ABC transporter signature motif; other site 930171006827 Walker B; other site 930171006828 D-loop; other site 930171006829 H-loop/switch region; other site 930171006830 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 930171006831 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 930171006832 active site 930171006833 metal binding site [ion binding]; metal-binding site 930171006834 DNA binding site [nucleotide binding] 930171006835 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 930171006836 amphipathic channel; other site 930171006837 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 930171006838 Asn-Pro-Ala signature motifs; other site 930171006839 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 930171006840 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 930171006841 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 930171006842 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 930171006843 active site 930171006844 catalytic site [active] 930171006845 substrate binding site [chemical binding]; other site 930171006846 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930171006847 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 930171006848 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 930171006849 active site 930171006850 dimerization interface [polypeptide binding]; other site 930171006851 ribonuclease PH; Reviewed; Region: rph; PRK00173 930171006852 Ribonuclease PH; Region: RNase_PH_bact; cd11362 930171006853 hexamer interface [polypeptide binding]; other site 930171006854 active site 930171006855 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 930171006856 glutamate racemase; Provisional; Region: PRK00865 930171006857 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 930171006858 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 930171006859 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 930171006860 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 930171006861 active site 930171006862 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 930171006863 Isochorismatase family; Region: Isochorismatase; pfam00857 930171006864 catalytic triad [active] 930171006865 metal binding site [ion binding]; metal-binding site 930171006866 conserved cis-peptide bond; other site 930171006867 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 930171006868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171006869 ATP binding site [chemical binding]; other site 930171006870 putative Mg++ binding site [ion binding]; other site 930171006871 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 930171006872 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 930171006873 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 930171006874 active site 930171006875 trimer interface [polypeptide binding]; other site 930171006876 allosteric site; other site 930171006877 active site lid [active] 930171006878 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930171006879 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 930171006880 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930171006881 Walker A/P-loop; other site 930171006882 ATP binding site [chemical binding]; other site 930171006883 Q-loop/lid; other site 930171006884 ABC transporter signature motif; other site 930171006885 Walker B; other site 930171006886 D-loop; other site 930171006887 H-loop/switch region; other site 930171006888 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 930171006889 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 930171006890 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 930171006891 active site 930171006892 FMN binding site [chemical binding]; other site 930171006893 substrate binding site [chemical binding]; other site 930171006894 homotetramer interface [polypeptide binding]; other site 930171006895 catalytic residue [active] 930171006896 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 930171006897 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 930171006898 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930171006899 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930171006900 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171006901 hypothetical protein; Provisional; Region: PRK03298 930171006902 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930171006903 DNA-binding site [nucleotide binding]; DNA binding site 930171006904 RNA-binding motif; other site 930171006905 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 930171006906 Putative esterase; Region: Esterase; pfam00756 930171006907 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 930171006908 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 930171006909 gamma subunit interface [polypeptide binding]; other site 930171006910 epsilon subunit interface [polypeptide binding]; other site 930171006911 LBP interface [polypeptide binding]; other site 930171006912 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 930171006913 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 930171006914 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 930171006915 alpha subunit interaction interface [polypeptide binding]; other site 930171006916 Walker A motif; other site 930171006917 ATP binding site [chemical binding]; other site 930171006918 Walker B motif; other site 930171006919 inhibitor binding site; inhibition site 930171006920 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930171006921 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 930171006922 core domain interface [polypeptide binding]; other site 930171006923 delta subunit interface [polypeptide binding]; other site 930171006924 epsilon subunit interface [polypeptide binding]; other site 930171006925 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 930171006926 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 930171006927 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 930171006928 beta subunit interaction interface [polypeptide binding]; other site 930171006929 Walker A motif; other site 930171006930 ATP binding site [chemical binding]; other site 930171006931 Walker B motif; other site 930171006932 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930171006933 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 930171006934 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 930171006935 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 930171006936 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636 930171006937 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 930171006938 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 930171006939 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 930171006940 Mg++ binding site [ion binding]; other site 930171006941 putative catalytic motif [active] 930171006942 substrate binding site [chemical binding]; other site 930171006943 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 930171006944 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930171006945 active site 930171006946 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 930171006947 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 930171006948 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 930171006949 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 930171006950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171006951 S-adenosylmethionine binding site [chemical binding]; other site 930171006952 peptide chain release factor 1; Validated; Region: prfA; PRK00591 930171006953 This domain is found in peptide chain release factors; Region: PCRF; smart00937 930171006954 RF-1 domain; Region: RF-1; pfam00472 930171006955 transcription termination factor Rho; Provisional; Region: PRK12608 930171006956 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 930171006957 RNA binding site [nucleotide binding]; other site 930171006958 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 930171006959 multimer interface [polypeptide binding]; other site 930171006960 Walker A motif; other site 930171006961 ATP binding site [chemical binding]; other site 930171006962 Walker B motif; other site 930171006963 homoserine kinase; Provisional; Region: PRK01212 930171006964 threonine synthase; Reviewed; Region: PRK06721 930171006965 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 930171006966 homodimer interface [polypeptide binding]; other site 930171006967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171006968 catalytic residue [active] 930171006969 homoserine dehydrogenase; Provisional; Region: PRK06349 930171006970 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 930171006971 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 930171006972 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 930171006973 diaminopimelate decarboxylase; Region: lysA; TIGR01048 930171006974 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 930171006975 active site 930171006976 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930171006977 substrate binding site [chemical binding]; other site 930171006978 catalytic residues [active] 930171006979 dimer interface [polypeptide binding]; other site 930171006980 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 930171006981 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 930171006982 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 930171006983 active site 930171006984 HIGH motif; other site 930171006985 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930171006986 KMSK motif region; other site 930171006987 tRNA binding surface [nucleotide binding]; other site 930171006988 DALR anticodon binding domain; Region: DALR_1; smart00836 930171006989 anticodon binding site; other site 930171006990 FMN-binding domain; Region: FMN_bind; cl01081 930171006991 ApbE family; Region: ApbE; pfam02424 930171006992 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 930171006993 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 930171006994 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 930171006995 FAD binding pocket [chemical binding]; other site 930171006996 conserved FAD binding motif [chemical binding]; other site 930171006997 phosphate binding motif [ion binding]; other site 930171006998 beta-alpha-beta structure motif; other site 930171006999 NAD binding pocket [chemical binding]; other site 930171007000 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 930171007001 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 930171007002 active site 930171007003 Zn binding site [ion binding]; other site 930171007004 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 930171007005 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 930171007006 conserved cys residue [active] 930171007007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930171007008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930171007009 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 930171007010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171007011 ATP binding site [chemical binding]; other site 930171007012 putative Mg++ binding site [ion binding]; other site 930171007013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171007014 nucleotide binding region [chemical binding]; other site 930171007015 ATP-binding site [chemical binding]; other site 930171007016 Helicase associated domain (HA2); Region: HA2; pfam04408 930171007017 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 930171007018 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 930171007019 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 930171007020 nucleotide binding site/active site [active] 930171007021 HIT family signature motif; other site 930171007022 catalytic residue [active] 930171007023 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 930171007024 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 930171007025 putative NAD(P) binding site [chemical binding]; other site 930171007026 putative substrate binding site [chemical binding]; other site 930171007027 catalytic Zn binding site [ion binding]; other site 930171007028 structural Zn binding site [ion binding]; other site 930171007029 dimer interface [polypeptide binding]; other site 930171007030 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 930171007031 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 930171007032 active site residue [active] 930171007033 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 930171007034 active site residue [active] 930171007035 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 930171007036 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 930171007037 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930171007038 catalytic residue [active] 930171007039 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 930171007040 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 930171007041 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 930171007042 metal binding site 2 [ion binding]; metal-binding site 930171007043 putative DNA binding helix; other site 930171007044 metal binding site 1 [ion binding]; metal-binding site 930171007045 dimer interface [polypeptide binding]; other site 930171007046 structural Zn2+ binding site [ion binding]; other site 930171007047 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 930171007048 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 930171007049 putative PBP binding regions; other site 930171007050 ABC-ATPase subunit interface; other site 930171007051 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 930171007052 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 930171007053 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 930171007054 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 930171007055 intersubunit interface [polypeptide binding]; other site 930171007056 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930171007057 Domain of unknown function DUF21; Region: DUF21; pfam01595 930171007058 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930171007059 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930171007060 Domain of unknown function DUF21; Region: DUF21; pfam01595 930171007061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930171007062 Transporter associated domain; Region: CorC_HlyC; smart01091 930171007063 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 930171007064 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930171007065 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 930171007066 TPP-binding site [chemical binding]; other site 930171007067 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 930171007068 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 930171007069 active site 930171007070 catalytic triad [active] 930171007071 oxyanion hole [active] 930171007072 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930171007073 Predicted transcriptional regulators [Transcription]; Region: COG1695 930171007074 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930171007075 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 930171007076 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 930171007077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930171007078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930171007079 DNA binding residues [nucleotide binding] 930171007080 DoxX; Region: DoxX; pfam07681 930171007081 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 930171007082 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 930171007083 hinge; other site 930171007084 active site 930171007085 GTPase RsgA; Reviewed; Region: PRK00098 930171007086 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 930171007087 GTPase/Zn-binding domain interface [polypeptide binding]; other site 930171007088 GTP/Mg2+ binding site [chemical binding]; other site 930171007089 G4 box; other site 930171007090 G5 box; other site 930171007091 G1 box; other site 930171007092 Switch I region; other site 930171007093 G2 box; other site 930171007094 G3 box; other site 930171007095 Switch II region; other site 930171007096 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 930171007097 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 930171007098 active site 930171007099 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 930171007100 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930171007101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930171007102 catalytic residue [active] 930171007103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171007104 S-adenosylmethionine binding site [chemical binding]; other site 930171007105 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 930171007106 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 930171007107 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 930171007108 FeoA domain; Region: FeoA; pfam04023 930171007109 CrcB-like protein; Region: CRCB; pfam02537 930171007110 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 930171007111 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 930171007112 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 930171007113 protein binding site [polypeptide binding]; other site 930171007114 Helix-turn-helix domain; Region: HTH_28; pfam13518 930171007115 Winged helix-turn helix; Region: HTH_29; pfam13551 930171007116 Homeodomain-like domain; Region: HTH_32; pfam13565 930171007117 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 930171007118 Integrase core domain; Region: rve; pfam00665 930171007119 Integrase core domain; Region: rve_3; pfam13683 930171007120 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 930171007121 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 930171007122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171007123 NAD(P) binding site [chemical binding]; other site 930171007124 active site 930171007125 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 930171007126 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 930171007127 NAD binding site [chemical binding]; other site 930171007128 substrate binding site [chemical binding]; other site 930171007129 homodimer interface [polypeptide binding]; other site 930171007130 active site 930171007131 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 930171007132 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 930171007133 substrate binding site; other site 930171007134 tetramer interface; other site 930171007135 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 930171007136 SmpB-tmRNA interface; other site 930171007137 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930171007138 Peptidase family M23; Region: Peptidase_M23; pfam01551 930171007139 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 930171007140 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 930171007141 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 930171007142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171007143 Walker A/P-loop; other site 930171007144 ATP binding site [chemical binding]; other site 930171007145 Q-loop/lid; other site 930171007146 ABC transporter signature motif; other site 930171007147 Walker B; other site 930171007148 D-loop; other site 930171007149 H-loop/switch region; other site 930171007150 peptide chain release factor 2; Validated; Region: prfB; PRK00578 930171007151 This domain is found in peptide chain release factors; Region: PCRF; smart00937 930171007152 RF-1 domain; Region: RF-1; pfam00472 930171007153 TadE-like protein; Region: TadE; pfam07811 930171007154 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 930171007155 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 930171007156 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 930171007157 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 930171007158 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 930171007159 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 930171007160 ATP binding site [chemical binding]; other site 930171007161 Walker A motif; other site 930171007162 hexamer interface [polypeptide binding]; other site 930171007163 Walker B motif; other site 930171007164 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 930171007165 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 930171007166 active site 930171007167 LGFP repeat; Region: LGFP; pfam08310 930171007168 LGFP repeat; Region: LGFP; pfam08310 930171007169 LGFP repeat; Region: LGFP; pfam08310 930171007170 LGFP repeat; Region: LGFP; pfam08310 930171007171 LGFP repeat; Region: LGFP; pfam08310 930171007172 LGFP repeat; Region: LGFP; pfam08310 930171007173 LGFP repeat; Region: LGFP; pfam08310 930171007174 LGFP repeat; Region: LGFP; pfam08310 930171007175 LGFP repeat; Region: LGFP; pfam08310 930171007176 LGFP repeat; Region: LGFP; pfam08310 930171007177 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 930171007178 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 930171007179 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 930171007180 Ligand binding site; other site 930171007181 Putative Catalytic site; other site 930171007182 DXD motif; other site 930171007183 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 930171007184 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 930171007185 NAD(P) binding site [chemical binding]; other site 930171007186 homodimer interface [polypeptide binding]; other site 930171007187 substrate binding site [chemical binding]; other site 930171007188 active site 930171007189 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 930171007190 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 930171007191 putative glycosyl transferase; Provisional; Region: PRK10307 930171007192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 930171007193 Transposase; Region: DDE_Tnp_ISL3; pfam01610 930171007194 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171007195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171007196 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171007197 Homeodomain-like domain; Region: HTH_23; pfam13384 930171007198 Winged helix-turn helix; Region: HTH_29; pfam13551 930171007199 Helix-turn-helix domain; Region: HTH_38; pfam13936 930171007200 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 930171007201 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 930171007202 active site 930171007203 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 930171007204 homodimer interface [polypeptide binding]; other site 930171007205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171007206 NAD(P) binding site [chemical binding]; other site 930171007207 active site 930171007208 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 930171007209 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 930171007210 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 930171007211 Walker A/P-loop; other site 930171007212 ATP binding site [chemical binding]; other site 930171007213 Q-loop/lid; other site 930171007214 ABC transporter signature motif; other site 930171007215 Walker B; other site 930171007216 D-loop; other site 930171007217 H-loop/switch region; other site 930171007218 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930171007219 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930171007220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930171007221 active site 930171007222 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 930171007223 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930171007224 UDP-galactopyranose mutase; Region: GLF; pfam03275 930171007225 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 930171007226 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 930171007227 putative trimer interface [polypeptide binding]; other site 930171007228 putative active site [active] 930171007229 putative substrate binding site [chemical binding]; other site 930171007230 putative CoA binding site [chemical binding]; other site 930171007231 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 930171007232 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 930171007233 phosphopeptide binding site; other site 930171007234 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 930171007235 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930171007236 Transcription factor WhiB; Region: Whib; pfam02467 930171007237 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 930171007238 PAS fold; Region: PAS_4; pfam08448 930171007239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 930171007240 Histidine kinase; Region: HisKA_2; pfam07568 930171007241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171007242 ATP binding site [chemical binding]; other site 930171007243 Mg2+ binding site [ion binding]; other site 930171007244 G-X-G motif; other site 930171007245 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 930171007246 AAA domain; Region: AAA_31; pfam13614 930171007247 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930171007248 Helix-turn-helix domain; Region: HTH_17; pfam12728 930171007249 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930171007250 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 930171007251 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 930171007252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 930171007253 nucleotide binding region [chemical binding]; other site 930171007254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 930171007255 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 930171007256 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 930171007257 30S subunit binding site; other site 930171007258 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 930171007259 lipoprotein LpqB; Provisional; Region: PRK13614 930171007260 Sporulation and spore germination; Region: Germane; pfam10646 930171007261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930171007262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930171007263 dimerization interface [polypeptide binding]; other site 930171007264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930171007265 dimer interface [polypeptide binding]; other site 930171007266 phosphorylation site [posttranslational modification] 930171007267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171007268 ATP binding site [chemical binding]; other site 930171007269 G-X-G motif; other site 930171007270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930171007271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171007272 active site 930171007273 phosphorylation site [posttranslational modification] 930171007274 intermolecular recognition site; other site 930171007275 dimerization interface [polypeptide binding]; other site 930171007276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930171007277 DNA binding site [nucleotide binding] 930171007278 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 930171007279 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 930171007280 MoxR-like ATPases [General function prediction only]; Region: COG0714 930171007281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171007282 Walker A motif; other site 930171007283 ATP binding site [chemical binding]; other site 930171007284 Walker B motif; other site 930171007285 arginine finger; other site 930171007286 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 930171007287 Protein of unknown function DUF58; Region: DUF58; pfam01882 930171007288 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 930171007289 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 930171007290 chorismate mutase; Provisional; Region: PRK09239 930171007291 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 930171007292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171007293 Walker A/P-loop; other site 930171007294 ATP binding site [chemical binding]; other site 930171007295 Q-loop/lid; other site 930171007296 ABC transporter signature motif; other site 930171007297 Walker B; other site 930171007298 D-loop; other site 930171007299 H-loop/switch region; other site 930171007300 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171007301 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171007302 Walker A/P-loop; other site 930171007303 ATP binding site [chemical binding]; other site 930171007304 Q-loop/lid; other site 930171007305 ABC transporter signature motif; other site 930171007306 Walker B; other site 930171007307 D-loop; other site 930171007308 H-loop/switch region; other site 930171007309 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171007310 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930171007311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171007312 dimer interface [polypeptide binding]; other site 930171007313 conserved gate region; other site 930171007314 putative PBP binding loops; other site 930171007315 ABC-ATPase subunit interface; other site 930171007316 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 930171007317 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 930171007318 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 930171007319 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 930171007320 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 930171007321 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 930171007322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930171007323 catalytic residue [active] 930171007324 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 930171007325 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 930171007326 HSP70 interaction site [polypeptide binding]; other site 930171007327 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 930171007328 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 930171007329 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930171007330 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930171007331 DNA binding residues [nucleotide binding] 930171007332 Anti-sigma-K factor rskA; Region: RskA; pfam10099 930171007333 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 930171007334 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 930171007335 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 930171007336 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 930171007337 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 930171007338 Ligand binding site [chemical binding]; other site 930171007339 Electron transfer flavoprotein domain; Region: ETF; pfam01012 930171007340 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 930171007341 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 930171007342 protein binding site [polypeptide binding]; other site 930171007343 Repair protein; Region: Repair_PSII; cl01535 930171007344 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 930171007345 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 930171007346 DNA photolyase; Region: DNA_photolyase; pfam00875 930171007347 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 930171007348 Uncharacterized conserved protein [Function unknown]; Region: COG1615 930171007349 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 930171007350 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 930171007351 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 930171007352 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 930171007353 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 930171007354 Protein of unknown function DUF45; Region: DUF45; cl00636 930171007355 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 930171007356 Part of AAA domain; Region: AAA_19; pfam13245 930171007357 Family description; Region: UvrD_C_2; pfam13538 930171007358 HRDC domain; Region: HRDC; pfam00570 930171007359 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 930171007360 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 930171007361 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 930171007362 putative NADH binding site [chemical binding]; other site 930171007363 putative active site [active] 930171007364 nudix motif; other site 930171007365 putative metal binding site [ion binding]; other site 930171007366 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 930171007367 Phosphotransferase enzyme family; Region: APH; pfam01636 930171007368 active site 930171007369 ATP binding site [chemical binding]; other site 930171007370 substrate binding site [chemical binding]; other site 930171007371 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 930171007372 Part of AAA domain; Region: AAA_19; pfam13245 930171007373 Family description; Region: UvrD_C_2; pfam13538 930171007374 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 930171007375 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 930171007376 Part of AAA domain; Region: AAA_19; pfam13245 930171007377 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 930171007378 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930171007379 DNA binding site [nucleotide binding] 930171007380 active site 930171007381 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 930171007382 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 930171007383 active site 930171007384 catalytic site [active] 930171007385 substrate binding site [chemical binding]; other site 930171007386 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930171007387 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930171007388 substrate binding pocket [chemical binding]; other site 930171007389 membrane-bound complex binding site; other site 930171007390 hinge residues; other site 930171007391 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930171007392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171007393 dimer interface [polypeptide binding]; other site 930171007394 conserved gate region; other site 930171007395 putative PBP binding loops; other site 930171007396 ABC-ATPase subunit interface; other site 930171007397 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930171007398 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930171007399 Walker A/P-loop; other site 930171007400 ATP binding site [chemical binding]; other site 930171007401 Q-loop/lid; other site 930171007402 ABC transporter signature motif; other site 930171007403 Walker B; other site 930171007404 D-loop; other site 930171007405 H-loop/switch region; other site 930171007406 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 930171007407 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930171007408 inhibitor-cofactor binding pocket; inhibition site 930171007409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171007410 catalytic residue [active] 930171007411 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 930171007412 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 930171007413 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 930171007414 dimer interface [polypeptide binding]; other site 930171007415 active site 930171007416 Schiff base residues; other site 930171007417 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 930171007418 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 930171007419 active site 930171007420 ferrochelatase; Reviewed; Region: hemH; PRK00035 930171007421 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 930171007422 C-terminal domain interface [polypeptide binding]; other site 930171007423 active site 930171007424 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 930171007425 active site 930171007426 N-terminal domain interface [polypeptide binding]; other site 930171007427 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 930171007428 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 930171007429 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 930171007430 substrate binding site [chemical binding]; other site 930171007431 active site 930171007432 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 930171007433 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 930171007434 NAD(P) binding pocket [chemical binding]; other site 930171007435 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 930171007436 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 930171007437 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 930171007438 ATP binding site [chemical binding]; other site 930171007439 substrate interface [chemical binding]; other site 930171007440 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930171007441 active site residue [active] 930171007442 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 930171007443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171007444 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 930171007445 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 930171007446 aromatic arch; other site 930171007447 DCoH dimer interaction site [polypeptide binding]; other site 930171007448 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 930171007449 DCoH tetramer interaction site [polypeptide binding]; other site 930171007450 substrate binding site [chemical binding]; other site 930171007451 thiazole synthase; Reviewed; Region: thiG; PRK00208 930171007452 phosphate binding site [ion binding]; other site 930171007453 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 930171007454 thiS-thiF/thiG interaction site; other site 930171007455 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 930171007456 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 930171007457 thiamine phosphate binding site [chemical binding]; other site 930171007458 active site 930171007459 pyrophosphate binding site [ion binding]; other site 930171007460 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 930171007461 RNB domain; Region: RNB; pfam00773 930171007462 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930171007463 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930171007464 ATP binding site [chemical binding]; other site 930171007465 Mg++ binding site [ion binding]; other site 930171007466 motif III; other site 930171007467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171007468 nucleotide binding region [chemical binding]; other site 930171007469 ATP-binding site [chemical binding]; other site 930171007470 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 930171007471 DNA methylase; Region: N6_N4_Mtase; pfam01555 930171007472 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 930171007473 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 930171007474 active site 930171007475 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 930171007476 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 930171007477 proline aminopeptidase P II; Provisional; Region: PRK10879 930171007478 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 930171007479 active site 930171007480 PRC-barrel domain; Region: PRC; pfam05239 930171007481 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 930171007482 MgtE intracellular N domain; Region: MgtE_N; smart00924 930171007483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 930171007484 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 930171007485 Domain of unknown function DUF59; Region: DUF59; pfam01883 930171007486 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 930171007487 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 930171007488 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 930171007489 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 930171007490 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930171007491 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930171007492 DNA binding residues [nucleotide binding] 930171007493 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 930171007494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171007495 S-adenosylmethionine binding site [chemical binding]; other site 930171007496 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 930171007497 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 930171007498 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930171007499 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930171007500 Walker A/P-loop; other site 930171007501 ATP binding site [chemical binding]; other site 930171007502 Q-loop/lid; other site 930171007503 ABC transporter signature motif; other site 930171007504 Walker B; other site 930171007505 D-loop; other site 930171007506 H-loop/switch region; other site 930171007507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930171007508 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930171007509 substrate binding pocket [chemical binding]; other site 930171007510 membrane-bound complex binding site; other site 930171007511 hinge residues; other site 930171007512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171007513 dimer interface [polypeptide binding]; other site 930171007514 conserved gate region; other site 930171007515 putative PBP binding loops; other site 930171007516 ABC-ATPase subunit interface; other site 930171007517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930171007518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171007519 putative PBP binding loops; other site 930171007520 ABC-ATPase subunit interface; other site 930171007521 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 930171007522 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 930171007523 metal binding site [ion binding]; metal-binding site 930171007524 putative dimer interface [polypeptide binding]; other site 930171007525 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 930171007526 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 930171007527 putative trimer interface [polypeptide binding]; other site 930171007528 putative CoA binding site [chemical binding]; other site 930171007529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171007530 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 930171007531 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 930171007532 UDP-glucose 4-epimerase; Region: PLN02240 930171007533 NAD binding site [chemical binding]; other site 930171007534 homodimer interface [polypeptide binding]; other site 930171007535 active site 930171007536 substrate binding site [chemical binding]; other site 930171007537 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 930171007538 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 930171007539 dimer interface [polypeptide binding]; other site 930171007540 active site 930171007541 citrylCoA binding site [chemical binding]; other site 930171007542 NADH binding [chemical binding]; other site 930171007543 cationic pore residues; other site 930171007544 oxalacetate/citrate binding site [chemical binding]; other site 930171007545 coenzyme A binding site [chemical binding]; other site 930171007546 catalytic triad [active] 930171007547 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 930171007548 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171007549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171007550 homodimer interface [polypeptide binding]; other site 930171007551 catalytic residue [active] 930171007552 Ferredoxin [Energy production and conversion]; Region: COG1146 930171007553 4Fe-4S binding domain; Region: Fer4; pfam00037 930171007554 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 930171007555 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 930171007556 G1 box; other site 930171007557 putative GEF interaction site [polypeptide binding]; other site 930171007558 GTP/Mg2+ binding site [chemical binding]; other site 930171007559 Switch I region; other site 930171007560 G2 box; other site 930171007561 G3 box; other site 930171007562 Switch II region; other site 930171007563 G4 box; other site 930171007564 G5 box; other site 930171007565 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 930171007566 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 930171007567 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 930171007568 active site 930171007569 catalytic triad [active] 930171007570 oxyanion hole [active] 930171007571 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 930171007572 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171007573 Walker A/P-loop; other site 930171007574 ATP binding site [chemical binding]; other site 930171007575 Q-loop/lid; other site 930171007576 ABC transporter signature motif; other site 930171007577 Walker B; other site 930171007578 D-loop; other site 930171007579 H-loop/switch region; other site 930171007580 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171007581 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171007582 Walker A/P-loop; other site 930171007583 ATP binding site [chemical binding]; other site 930171007584 Q-loop/lid; other site 930171007585 ABC transporter signature motif; other site 930171007586 Walker B; other site 930171007587 D-loop; other site 930171007588 H-loop/switch region; other site 930171007589 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171007590 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930171007591 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 930171007592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171007593 dimer interface [polypeptide binding]; other site 930171007594 conserved gate region; other site 930171007595 putative PBP binding loops; other site 930171007596 ABC-ATPase subunit interface; other site 930171007597 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930171007598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171007599 dimer interface [polypeptide binding]; other site 930171007600 conserved gate region; other site 930171007601 ABC-ATPase subunit interface; other site 930171007602 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 930171007603 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930171007604 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 930171007605 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 930171007606 GTP-binding protein YchF; Reviewed; Region: PRK09601 930171007607 YchF GTPase; Region: YchF; cd01900 930171007608 G1 box; other site 930171007609 GTP/Mg2+ binding site [chemical binding]; other site 930171007610 Switch I region; other site 930171007611 G2 box; other site 930171007612 Switch II region; other site 930171007613 G3 box; other site 930171007614 G4 box; other site 930171007615 G5 box; other site 930171007616 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 930171007617 RmuC family; Region: RmuC; pfam02646 930171007618 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 930171007619 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 930171007620 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 930171007621 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 930171007622 generic binding surface II; other site 930171007623 generic binding surface I; other site 930171007624 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 930171007625 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 930171007626 aminotransferase AlaT; Validated; Region: PRK09265 930171007627 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171007628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171007629 homodimer interface [polypeptide binding]; other site 930171007630 catalytic residue [active] 930171007631 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 930171007632 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930171007633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171007634 ABC-ATPase subunit interface; other site 930171007635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171007636 dimer interface [polypeptide binding]; other site 930171007637 conserved gate region; other site 930171007638 ABC-ATPase subunit interface; other site 930171007639 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930171007640 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 930171007641 Walker A/P-loop; other site 930171007642 ATP binding site [chemical binding]; other site 930171007643 Q-loop/lid; other site 930171007644 ABC transporter signature motif; other site 930171007645 Walker B; other site 930171007646 D-loop; other site 930171007647 H-loop/switch region; other site 930171007648 Pirin-related protein [General function prediction only]; Region: COG1741 930171007649 Pirin; Region: Pirin; pfam02678 930171007650 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 930171007651 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 930171007652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930171007653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171007654 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 930171007655 putative dimerization interface [polypeptide binding]; other site 930171007656 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 930171007657 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930171007658 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 930171007659 putative DNA binding site [nucleotide binding]; other site 930171007660 putative Zn2+ binding site [ion binding]; other site 930171007661 AsnC family; Region: AsnC_trans_reg; pfam01037 930171007662 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930171007663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171007664 dimerization interface [polypeptide binding]; other site 930171007665 putative DNA binding site [nucleotide binding]; other site 930171007666 putative Zn2+ binding site [ion binding]; other site 930171007667 AsnC family; Region: AsnC_trans_reg; pfam01037 930171007668 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 930171007669 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 930171007670 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 930171007671 oligomer interface [polypeptide binding]; other site 930171007672 metal binding site [ion binding]; metal-binding site 930171007673 metal binding site [ion binding]; metal-binding site 930171007674 putative Cl binding site [ion binding]; other site 930171007675 basic sphincter; other site 930171007676 hydrophobic gate; other site 930171007677 periplasmic entrance; other site 930171007678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930171007679 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930171007680 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 930171007681 tetramer interface; other site 930171007682 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 930171007683 active site 930171007684 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 930171007685 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 930171007686 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 930171007687 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 930171007688 Part of AAA domain; Region: AAA_19; pfam13245 930171007689 GMP synthase; Reviewed; Region: guaA; PRK00074 930171007690 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 930171007691 AMP/PPi binding site [chemical binding]; other site 930171007692 candidate oxyanion hole; other site 930171007693 catalytic triad [active] 930171007694 potential glutamine specificity residues [chemical binding]; other site 930171007695 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 930171007696 ATP Binding subdomain [chemical binding]; other site 930171007697 Ligand Binding sites [chemical binding]; other site 930171007698 Dimerization subdomain; other site 930171007699 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 930171007700 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 930171007701 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930171007702 active site 930171007703 phosphorylation site [posttranslational modification] 930171007704 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 930171007705 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 930171007706 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 930171007707 active site 930171007708 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930171007709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171007710 Walker A/P-loop; other site 930171007711 ATP binding site [chemical binding]; other site 930171007712 Q-loop/lid; other site 930171007713 ABC transporter signature motif; other site 930171007714 Walker B; other site 930171007715 D-loop; other site 930171007716 H-loop/switch region; other site 930171007717 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 930171007718 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 930171007719 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 930171007720 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 930171007721 active site 930171007722 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 930171007723 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 930171007724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 930171007725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171007726 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171007727 DNA binding residues [nucleotide binding] 930171007728 dimerization interface [polypeptide binding]; other site 930171007729 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 930171007730 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 930171007731 active site 930171007732 DNA binding site [nucleotide binding] 930171007733 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 930171007734 DNA binding site [nucleotide binding] 930171007735 RibD C-terminal domain; Region: RibD_C; cl17279 930171007736 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 930171007737 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 930171007738 ring oligomerisation interface [polypeptide binding]; other site 930171007739 ATP/Mg binding site [chemical binding]; other site 930171007740 stacking interactions; other site 930171007741 hinge regions; other site 930171007742 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 930171007743 oligomerisation interface [polypeptide binding]; other site 930171007744 mobile loop; other site 930171007745 roof hairpin; other site 930171007746 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 930171007747 EamA-like transporter family; Region: EamA; pfam00892 930171007748 EamA-like transporter family; Region: EamA; pfam00892 930171007749 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 930171007750 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 930171007751 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 930171007752 shikimate binding site; other site 930171007753 NAD(P) binding site [chemical binding]; other site 930171007754 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 930171007755 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 930171007756 carboxylate-amine ligase; Provisional; Region: PRK13517 930171007757 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 930171007758 UGMP family protein; Validated; Region: PRK09604 930171007759 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 930171007760 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 930171007761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930171007762 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 930171007763 Glycoprotease family; Region: Peptidase_M22; pfam00814 930171007764 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 930171007765 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 930171007766 alanine racemase; Reviewed; Region: alr; PRK00053 930171007767 active site 930171007768 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930171007769 dimer interface [polypeptide binding]; other site 930171007770 substrate binding site [chemical binding]; other site 930171007771 catalytic residues [active] 930171007772 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930171007773 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 930171007774 substrate binding site [chemical binding]; other site 930171007775 ATP binding site [chemical binding]; other site 930171007776 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 930171007777 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 930171007778 NAD(P) binding site [chemical binding]; other site 930171007779 LDH/MDH dimer interface [polypeptide binding]; other site 930171007780 substrate binding site [chemical binding]; other site 930171007781 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 930171007782 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 930171007783 putative ADP-binding pocket [chemical binding]; other site 930171007784 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 930171007785 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 930171007786 Potassium binding sites [ion binding]; other site 930171007787 Cesium cation binding sites [ion binding]; other site 930171007788 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 930171007789 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 930171007790 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171007791 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171007792 active site 930171007793 catalytic tetrad [active] 930171007794 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 930171007795 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 930171007796 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 930171007797 catalytic site [active] 930171007798 active site 930171007799 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 930171007800 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 930171007801 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 930171007802 active site 930171007803 catalytic site [active] 930171007804 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 930171007805 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 930171007806 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 930171007807 active site 930171007808 catalytic site [active] 930171007809 Uncharacterized conserved protein [Function unknown]; Region: COG0062 930171007810 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 930171007811 putative substrate binding site [chemical binding]; other site 930171007812 putative ATP binding site [chemical binding]; other site 930171007813 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 930171007814 pantothenate kinase; Provisional; Region: PRK05439 930171007815 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 930171007816 ATP-binding site [chemical binding]; other site 930171007817 CoA-binding site [chemical binding]; other site 930171007818 Mg2+-binding site [ion binding]; other site 930171007819 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 930171007820 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 930171007821 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 930171007822 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 930171007823 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 930171007824 active site 930171007825 substrate binding site [chemical binding]; other site 930171007826 metal binding site [ion binding]; metal-binding site 930171007827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930171007828 active site 930171007829 Predicted membrane protein [Function unknown]; Region: COG2246 930171007830 GtrA-like protein; Region: GtrA; pfam04138 930171007831 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 930171007832 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 930171007833 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 930171007834 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 930171007835 23S rRNA interface [nucleotide binding]; other site 930171007836 L3 interface [polypeptide binding]; other site 930171007837 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 930171007838 TadE-like protein; Region: TadE; pfam07811 930171007839 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 930171007840 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 930171007841 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 930171007842 AAA domain; Region: AAA_31; pfam13614 930171007843 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 930171007844 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 930171007845 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 930171007846 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 930171007847 ATP binding site [chemical binding]; other site 930171007848 Walker A motif; other site 930171007849 hexamer interface [polypeptide binding]; other site 930171007850 Walker B motif; other site 930171007851 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 930171007852 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 930171007853 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 930171007854 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 930171007855 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 930171007856 TadE-like protein; Region: TadE; pfam07811 930171007857 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 930171007858 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 930171007859 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 930171007860 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 930171007861 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 930171007862 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 930171007863 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 930171007864 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 930171007865 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 930171007866 ATP binding site [chemical binding]; other site 930171007867 Walker A motif; other site 930171007868 hexamer interface [polypeptide binding]; other site 930171007869 Walker B motif; other site 930171007870 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 930171007871 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 930171007872 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 930171007873 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 930171007874 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930171007875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171007876 active site 930171007877 phosphorylation site [posttranslational modification] 930171007878 intermolecular recognition site; other site 930171007879 dimerization interface [polypeptide binding]; other site 930171007880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930171007881 DNA binding site [nucleotide binding] 930171007882 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 930171007883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930171007884 dimer interface [polypeptide binding]; other site 930171007885 phosphorylation site [posttranslational modification] 930171007886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171007887 ATP binding site [chemical binding]; other site 930171007888 Mg2+ binding site [ion binding]; other site 930171007889 G-X-G motif; other site 930171007890 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 930171007891 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 930171007892 dimerization interface 3.5A [polypeptide binding]; other site 930171007893 active site 930171007894 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 930171007895 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 930171007896 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 930171007897 alphaNTD homodimer interface [polypeptide binding]; other site 930171007898 alphaNTD - beta interaction site [polypeptide binding]; other site 930171007899 alphaNTD - beta' interaction site [polypeptide binding]; other site 930171007900 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 930171007901 30S ribosomal protein S11; Validated; Region: PRK05309 930171007902 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 930171007903 30S ribosomal protein S13; Region: bact_S13; TIGR03631 930171007904 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 930171007905 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 930171007906 rRNA binding site [nucleotide binding]; other site 930171007907 predicted 30S ribosome binding site; other site 930171007908 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 930171007909 putative active site pocket [active] 930171007910 cleavage site 930171007911 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 930171007912 active site 930171007913 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 930171007914 adenylate kinase; Reviewed; Region: adk; PRK00279 930171007915 AMP-binding site [chemical binding]; other site 930171007916 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 930171007917 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 930171007918 SecY translocase; Region: SecY; pfam00344 930171007919 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 930171007920 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 930171007921 23S rRNA binding site [nucleotide binding]; other site 930171007922 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 930171007923 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 930171007924 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 930171007925 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 930171007926 5S rRNA interface [nucleotide binding]; other site 930171007927 23S rRNA interface [nucleotide binding]; other site 930171007928 L5 interface [polypeptide binding]; other site 930171007929 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 930171007930 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 930171007931 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 930171007932 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 930171007933 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 930171007934 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 930171007935 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 930171007936 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 930171007937 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 930171007938 RNA binding site [nucleotide binding]; other site 930171007939 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 930171007940 Helix-turn-helix domain; Region: HTH_38; pfam13936 930171007941 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 930171007942 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171007943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171007944 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171007945 transposase; Provisional; Region: PRK06526 930171007946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171007947 Walker A motif; other site 930171007948 ATP binding site [chemical binding]; other site 930171007949 Walker B motif; other site 930171007950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 930171007951 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 930171007952 Integrase core domain; Region: rve; pfam00665 930171007953 Helix-turn-helix domain; Region: HTH_28; pfam13518 930171007954 HTH-like domain; Region: HTH_21; pfam13276 930171007955 Integrase core domain; Region: rve; pfam00665 930171007956 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171007957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171007958 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171007959 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 930171007960 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 930171007961 23S rRNA interface [nucleotide binding]; other site 930171007962 putative translocon interaction site; other site 930171007963 signal recognition particle (SRP54) interaction site; other site 930171007964 L23 interface [polypeptide binding]; other site 930171007965 trigger factor interaction site; other site 930171007966 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 930171007967 23S rRNA interface [nucleotide binding]; other site 930171007968 5S rRNA interface [nucleotide binding]; other site 930171007969 putative antibiotic binding site [chemical binding]; other site 930171007970 L25 interface [polypeptide binding]; other site 930171007971 L27 interface [polypeptide binding]; other site 930171007972 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 930171007973 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 930171007974 G-X-X-G motif; other site 930171007975 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 930171007976 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 930171007977 putative translocon binding site; other site 930171007978 protein-rRNA interface [nucleotide binding]; other site 930171007979 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 930171007980 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 930171007981 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 930171007982 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 930171007983 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 930171007984 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 930171007985 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 930171007986 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 930171007987 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 930171007988 beta-galactosidase; Region: BGL; TIGR03356 930171007989 elongation factor Tu; Reviewed; Region: PRK00049 930171007990 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 930171007991 G1 box; other site 930171007992 GEF interaction site [polypeptide binding]; other site 930171007993 GTP/Mg2+ binding site [chemical binding]; other site 930171007994 Switch I region; other site 930171007995 G2 box; other site 930171007996 G3 box; other site 930171007997 Switch II region; other site 930171007998 G4 box; other site 930171007999 G5 box; other site 930171008000 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 930171008001 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 930171008002 Antibiotic Binding Site [chemical binding]; other site 930171008003 elongation factor G; Reviewed; Region: PRK00007 930171008004 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 930171008005 G1 box; other site 930171008006 putative GEF interaction site [polypeptide binding]; other site 930171008007 GTP/Mg2+ binding site [chemical binding]; other site 930171008008 Switch I region; other site 930171008009 G2 box; other site 930171008010 G3 box; other site 930171008011 Switch II region; other site 930171008012 G4 box; other site 930171008013 G5 box; other site 930171008014 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 930171008015 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 930171008016 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 930171008017 30S ribosomal protein S7; Validated; Region: PRK05302 930171008018 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 930171008019 S17 interaction site [polypeptide binding]; other site 930171008020 S8 interaction site; other site 930171008021 16S rRNA interaction site [nucleotide binding]; other site 930171008022 streptomycin interaction site [chemical binding]; other site 930171008023 23S rRNA interaction site [nucleotide binding]; other site 930171008024 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 930171008025 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 930171008026 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 930171008027 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 930171008028 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 930171008029 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 930171008030 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 930171008031 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 930171008032 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 930171008033 DNA binding site [nucleotide binding] 930171008034 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 930171008035 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 930171008036 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 930171008037 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 930171008038 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 930171008039 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 930171008040 RPB10 interaction site [polypeptide binding]; other site 930171008041 RPB1 interaction site [polypeptide binding]; other site 930171008042 RPB11 interaction site [polypeptide binding]; other site 930171008043 RPB3 interaction site [polypeptide binding]; other site 930171008044 RPB12 interaction site [polypeptide binding]; other site 930171008045 putative acyltransferase; Provisional; Region: PRK05790 930171008046 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930171008047 dimer interface [polypeptide binding]; other site 930171008048 active site 930171008049 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 930171008050 putative deacylase active site [active] 930171008051 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 930171008052 core dimer interface [polypeptide binding]; other site 930171008053 peripheral dimer interface [polypeptide binding]; other site 930171008054 L10 interface [polypeptide binding]; other site 930171008055 L11 interface [polypeptide binding]; other site 930171008056 putative EF-Tu interaction site [polypeptide binding]; other site 930171008057 putative EF-G interaction site [polypeptide binding]; other site 930171008058 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 930171008059 23S rRNA interface [nucleotide binding]; other site 930171008060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171008061 Coenzyme A binding pocket [chemical binding]; other site 930171008062 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 930171008063 mRNA/rRNA interface [nucleotide binding]; other site 930171008064 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 930171008065 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 930171008066 23S rRNA interface [nucleotide binding]; other site 930171008067 putative thiostrepton binding site; other site 930171008068 L7/L12 interface [polypeptide binding]; other site 930171008069 L25 interface [polypeptide binding]; other site 930171008070 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 930171008071 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 930171008072 putative homodimer interface [polypeptide binding]; other site 930171008073 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 930171008074 heterodimer interface [polypeptide binding]; other site 930171008075 homodimer interface [polypeptide binding]; other site 930171008076 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 930171008077 aspartate aminotransferase; Provisional; Region: PRK05764 930171008078 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171008079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171008080 homodimer interface [polypeptide binding]; other site 930171008081 catalytic residue [active] 930171008082 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171008083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171008084 active site 930171008085 phosphorylation site [posttranslational modification] 930171008086 intermolecular recognition site; other site 930171008087 dimerization interface [polypeptide binding]; other site 930171008088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171008089 DNA binding residues [nucleotide binding] 930171008090 dimerization interface [polypeptide binding]; other site 930171008091 PspC domain; Region: PspC; pfam04024 930171008092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930171008093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171008094 ATP binding site [chemical binding]; other site 930171008095 Mg2+ binding site [ion binding]; other site 930171008096 G-X-G motif; other site 930171008097 PspC domain; Region: PspC; pfam04024 930171008098 PspC domain; Region: PspC; pfam04024 930171008099 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 930171008100 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 930171008101 active site 930171008102 ADP/pyrophosphate binding site [chemical binding]; other site 930171008103 dimerization interface [polypeptide binding]; other site 930171008104 allosteric effector site; other site 930171008105 fructose-1,6-bisphosphate binding site; other site 930171008106 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930171008107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930171008108 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 930171008109 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 930171008110 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 930171008111 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 930171008112 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 930171008113 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 930171008114 heme-binding site [chemical binding]; other site 930171008115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930171008116 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930171008117 DNA binding site [nucleotide binding] 930171008118 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 930171008119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171008120 Coenzyme A binding pocket [chemical binding]; other site 930171008121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171008122 Coenzyme A binding pocket [chemical binding]; other site 930171008123 polyphosphate kinase; Provisional; Region: PRK05443 930171008124 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 930171008125 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 930171008126 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 930171008127 putative domain interface [polypeptide binding]; other site 930171008128 putative active site [active] 930171008129 catalytic site [active] 930171008130 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 930171008131 putative domain interface [polypeptide binding]; other site 930171008132 putative active site [active] 930171008133 catalytic site [active] 930171008134 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 930171008135 active site 930171008136 Ap6A binding site [chemical binding]; other site 930171008137 nudix motif; other site 930171008138 metal binding site [ion binding]; metal-binding site 930171008139 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930171008140 catalytic core [active] 930171008141 thymidylate synthase; Reviewed; Region: thyA; PRK01827 930171008142 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 930171008143 dimerization interface [polypeptide binding]; other site 930171008144 active site 930171008145 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 930171008146 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 930171008147 folate binding site [chemical binding]; other site 930171008148 NADP+ binding site [chemical binding]; other site 930171008149 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 930171008150 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 930171008151 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 930171008152 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 930171008153 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 930171008154 FAD binding domain; Region: FAD_binding_4; pfam01565 930171008155 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 930171008156 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 930171008157 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 930171008158 active site 930171008159 catalytic site [active] 930171008160 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 930171008161 active site 930171008162 catalytic site [active] 930171008163 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 930171008164 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 930171008165 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 930171008166 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171008167 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171008168 active site 930171008169 catalytic tetrad [active] 930171008170 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930171008171 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 930171008172 active site 930171008173 catalytic site [active] 930171008174 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930171008175 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930171008176 nucleotide binding site [chemical binding]; other site 930171008177 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 930171008178 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 930171008179 NADH(P)-binding; Region: NAD_binding_10; pfam13460 930171008180 NAD(P) binding site [chemical binding]; other site 930171008181 putative active site [active] 930171008182 RibD C-terminal domain; Region: RibD_C; cl17279 930171008183 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 930171008184 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930171008185 ATP binding site [chemical binding]; other site 930171008186 Mg++ binding site [ion binding]; other site 930171008187 motif III; other site 930171008188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171008189 nucleotide binding region [chemical binding]; other site 930171008190 ATP-binding site [chemical binding]; other site 930171008191 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 930171008192 putative RNA binding site [nucleotide binding]; other site 930171008193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 930171008194 MOSC domain; Region: MOSC; pfam03473 930171008195 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 930171008196 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 930171008197 acyl-coenzyme A oxidase; Region: PLN02526 930171008198 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 930171008199 active site 930171008200 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 930171008201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171008202 NAD(P) binding site [chemical binding]; other site 930171008203 active site 930171008204 cystathionine gamma-synthase; Provisional; Region: PRK07811 930171008205 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930171008206 homodimer interface [polypeptide binding]; other site 930171008207 substrate-cofactor binding pocket; other site 930171008208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171008209 catalytic residue [active] 930171008210 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 930171008211 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 930171008212 dimer interface [polypeptide binding]; other site 930171008213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171008214 catalytic residue [active] 930171008215 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 930171008216 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171008217 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 930171008218 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 930171008219 minor groove reading motif; other site 930171008220 helix-hairpin-helix signature motif; other site 930171008221 active site 930171008222 AMP-binding domain protein; Validated; Region: PRK08315 930171008223 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930171008224 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 930171008225 acyl-activating enzyme (AAE) consensus motif; other site 930171008226 putative AMP binding site [chemical binding]; other site 930171008227 putative active site [active] 930171008228 putative CoA binding site [chemical binding]; other site 930171008229 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930171008230 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930171008231 catalytic residues [active] 930171008232 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930171008233 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930171008234 Walker A/P-loop; other site 930171008235 ATP binding site [chemical binding]; other site 930171008236 Q-loop/lid; other site 930171008237 ABC transporter signature motif; other site 930171008238 Walker B; other site 930171008239 D-loop; other site 930171008240 H-loop/switch region; other site 930171008241 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 930171008242 active site 930171008243 Ion channel; Region: Ion_trans_2; pfam07885 930171008244 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930171008245 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 930171008246 FOG: CBS domain [General function prediction only]; Region: COG0517 930171008247 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 930171008248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 930171008249 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 930171008250 heat shock protein HtpX; Provisional; Region: PRK03072 930171008251 H+ Antiporter protein; Region: 2A0121; TIGR00900 930171008252 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 930171008253 metal binding site 2 [ion binding]; metal-binding site 930171008254 putative DNA binding helix; other site 930171008255 metal binding site 1 [ion binding]; metal-binding site 930171008256 structural Zn2+ binding site [ion binding]; other site 930171008257 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 930171008258 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 930171008259 tetramer interface [polypeptide binding]; other site 930171008260 heme binding pocket [chemical binding]; other site 930171008261 NADPH binding site [chemical binding]; other site 930171008262 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 930171008263 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 930171008264 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 930171008265 Walker A/P-loop; other site 930171008266 ATP binding site [chemical binding]; other site 930171008267 Q-loop/lid; other site 930171008268 ABC transporter signature motif; other site 930171008269 Walker B; other site 930171008270 D-loop; other site 930171008271 H-loop/switch region; other site 930171008272 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930171008273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171008274 putative PBP binding loops; other site 930171008275 dimer interface [polypeptide binding]; other site 930171008276 ABC-ATPase subunit interface; other site 930171008277 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930171008278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930171008279 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930171008280 substrate binding pocket [chemical binding]; other site 930171008281 NMT1/THI5 like; Region: NMT1; pfam09084 930171008282 membrane-bound complex binding site; other site 930171008283 hinge residues; other site 930171008284 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 930171008285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171008286 amino acid transporter; Region: 2A0306; TIGR00909 930171008287 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 930171008288 Protein of unknown function (DUF779); Region: DUF779; pfam05610 930171008289 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 930171008290 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 930171008291 NAD binding site [chemical binding]; other site 930171008292 substrate binding site [chemical binding]; other site 930171008293 catalytic Zn binding site [ion binding]; other site 930171008294 tetramer interface [polypeptide binding]; other site 930171008295 structural Zn binding site [ion binding]; other site 930171008296 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 930171008297 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930171008298 NAD(P) binding site [chemical binding]; other site 930171008299 catalytic residues [active] 930171008300 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 930171008301 ferredoxin-NADP+ reductase; Region: PLN02852 930171008302 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930171008303 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 930171008304 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 930171008305 active site 930171008306 DNA binding site [nucleotide binding] 930171008307 Int/Topo IB signature motif; other site 930171008308 Predicted permeases [General function prediction only]; Region: RarD; COG2962 930171008309 EamA-like transporter family; Region: EamA; pfam00892 930171008310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 930171008311 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930171008312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171008313 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 930171008314 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930171008315 inhibitor-cofactor binding pocket; inhibition site 930171008316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171008317 catalytic residue [active] 930171008318 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 930171008319 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 930171008320 tetrameric interface [polypeptide binding]; other site 930171008321 NAD binding site [chemical binding]; other site 930171008322 catalytic residues [active] 930171008323 substrate binding site [chemical binding]; other site 930171008324 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 930171008325 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930171008326 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 930171008327 putative active site; other site 930171008328 putative metal binding residues [ion binding]; other site 930171008329 signature motif; other site 930171008330 putative triphosphate binding site [ion binding]; other site 930171008331 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 930171008332 cyanate transporter; Region: CynX; TIGR00896 930171008333 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930171008334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171008335 DNA-binding site [nucleotide binding]; DNA binding site 930171008336 FCD domain; Region: FCD; pfam07729 930171008337 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930171008338 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930171008339 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 930171008340 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 930171008341 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 930171008342 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 930171008343 hydrophobic ligand binding site; other site 930171008344 ferredoxin-NADP+ reductase; Region: PLN02852 930171008345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930171008346 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 930171008347 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 930171008348 active site 930171008349 SAM binding site [chemical binding]; other site 930171008350 homodimer interface [polypeptide binding]; other site 930171008351 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 930171008352 putative hydrophobic ligand binding site [chemical binding]; other site 930171008353 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930171008354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171008355 dimer interface [polypeptide binding]; other site 930171008356 conserved gate region; other site 930171008357 putative PBP binding loops; other site 930171008358 ABC-ATPase subunit interface; other site 930171008359 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 930171008360 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 930171008361 Walker A/P-loop; other site 930171008362 ATP binding site [chemical binding]; other site 930171008363 Q-loop/lid; other site 930171008364 ABC transporter signature motif; other site 930171008365 Walker B; other site 930171008366 D-loop; other site 930171008367 H-loop/switch region; other site 930171008368 NMT1/THI5 like; Region: NMT1; pfam09084 930171008369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930171008370 substrate binding pocket [chemical binding]; other site 930171008371 membrane-bound complex binding site; other site 930171008372 hinge residues; other site 930171008373 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 930171008374 hypothetical protein; Reviewed; Region: PRK09588 930171008375 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 930171008376 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 930171008377 CysD dimerization site [polypeptide binding]; other site 930171008378 G1 box; other site 930171008379 putative GEF interaction site [polypeptide binding]; other site 930171008380 GTP/Mg2+ binding site [chemical binding]; other site 930171008381 Switch I region; other site 930171008382 G2 box; other site 930171008383 G3 box; other site 930171008384 Switch II region; other site 930171008385 G4 box; other site 930171008386 G5 box; other site 930171008387 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 930171008388 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 930171008389 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 930171008390 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 930171008391 Active Sites [active] 930171008392 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 930171008393 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 930171008394 Active Sites [active] 930171008395 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 930171008396 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 930171008397 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 930171008398 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 930171008399 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 930171008400 putative active site [active] 930171008401 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 930171008402 putative active site [active] 930171008403 Predicted membrane protein [Function unknown]; Region: COG2860 930171008404 UPF0126 domain; Region: UPF0126; pfam03458 930171008405 UPF0126 domain; Region: UPF0126; pfam03458 930171008406 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 930171008407 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 930171008408 substrate binding pocket [chemical binding]; other site 930171008409 chain length determination region; other site 930171008410 substrate-Mg2+ binding site; other site 930171008411 catalytic residues [active] 930171008412 aspartate-rich region 1; other site 930171008413 active site lid residues [active] 930171008414 aspartate-rich region 2; other site 930171008415 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 930171008416 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930171008417 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 930171008418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171008419 S-adenosylmethionine binding site [chemical binding]; other site 930171008420 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 930171008421 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930171008422 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930171008423 substrate binding pocket [chemical binding]; other site 930171008424 membrane-bound complex binding site; other site 930171008425 hinge residues; other site 930171008426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171008427 dimer interface [polypeptide binding]; other site 930171008428 conserved gate region; other site 930171008429 putative PBP binding loops; other site 930171008430 ABC-ATPase subunit interface; other site 930171008431 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930171008432 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930171008433 Walker A/P-loop; other site 930171008434 ATP binding site [chemical binding]; other site 930171008435 Q-loop/lid; other site 930171008436 ABC transporter signature motif; other site 930171008437 Walker B; other site 930171008438 D-loop; other site 930171008439 H-loop/switch region; other site 930171008440 aspartate aminotransferase; Provisional; Region: PRK06836 930171008441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171008442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171008443 homodimer interface [polypeptide binding]; other site 930171008444 catalytic residue [active] 930171008445 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 930171008446 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 930171008447 dimer interface [polypeptide binding]; other site 930171008448 tetramer interface [polypeptide binding]; other site 930171008449 PYR/PP interface [polypeptide binding]; other site 930171008450 TPP binding site [chemical binding]; other site 930171008451 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 930171008452 TPP-binding site; other site 930171008453 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 930171008454 O-succinylbenzoate synthase; Provisional; Region: PRK02901 930171008455 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 930171008456 active site 930171008457 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 930171008458 active site 930171008459 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171008460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171008461 dimer interface [polypeptide binding]; other site 930171008462 conserved gate region; other site 930171008463 putative PBP binding loops; other site 930171008464 ABC-ATPase subunit interface; other site 930171008465 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 930171008466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171008467 dimer interface [polypeptide binding]; other site 930171008468 conserved gate region; other site 930171008469 putative PBP binding loops; other site 930171008470 ABC-ATPase subunit interface; other site 930171008471 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171008472 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 930171008473 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171008474 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171008475 DNA binding site [nucleotide binding] 930171008476 domain linker motif; other site 930171008477 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 930171008478 ligand binding site [chemical binding]; other site 930171008479 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 930171008480 Predicted membrane protein [Function unknown]; Region: COG2246 930171008481 GtrA-like protein; Region: GtrA; pfam04138 930171008482 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 930171008483 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930171008484 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930171008485 active site 930171008486 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 930171008487 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 930171008488 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 930171008489 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 930171008490 active site 930171008491 dimer interface [polypeptide binding]; other site 930171008492 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 930171008493 Ligand Binding Site [chemical binding]; other site 930171008494 Molecular Tunnel; other site 930171008495 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930171008496 catalytic residue [active] 930171008497 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 930171008498 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 930171008499 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 930171008500 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 930171008501 catalytic triad [active] 930171008502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 930171008503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 930171008504 Domain of unknown function DUF302; Region: DUF302; cl01364 930171008505 LssY C-terminus; Region: LssY_C; pfam14067 930171008506 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171008507 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 930171008508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171008509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171008510 putative substrate translocation pore; other site 930171008511 Catalytic domain of Protein Kinases; Region: PKc; cd00180 930171008512 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930171008513 active site 930171008514 ATP binding site [chemical binding]; other site 930171008515 substrate binding site [chemical binding]; other site 930171008516 activation loop (A-loop); other site 930171008517 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 930171008518 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930171008519 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 930171008520 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930171008521 Walker A/P-loop; other site 930171008522 ATP binding site [chemical binding]; other site 930171008523 Q-loop/lid; other site 930171008524 ABC transporter signature motif; other site 930171008525 Walker B; other site 930171008526 D-loop; other site 930171008527 H-loop/switch region; other site 930171008528 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 930171008529 6-phosphofructokinase 2; Provisional; Region: PRK10294 930171008530 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 930171008531 putative substrate binding site [chemical binding]; other site 930171008532 putative ATP binding site [chemical binding]; other site 930171008533 HipA N-terminal domain; Region: Couple_hipA; pfam13657 930171008534 HipA-like N-terminal domain; Region: HipA_N; pfam07805 930171008535 HipA-like C-terminal domain; Region: HipA_C; pfam07804 930171008536 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930171008537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171008538 non-specific DNA binding site [nucleotide binding]; other site 930171008539 salt bridge; other site 930171008540 sequence-specific DNA binding site [nucleotide binding]; other site 930171008541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171008542 NADH(P)-binding; Region: NAD_binding_10; pfam13460 930171008543 NAD(P) binding site [chemical binding]; other site 930171008544 active site 930171008545 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171008546 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171008547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171008548 active site 930171008549 phosphorylation site [posttranslational modification] 930171008550 intermolecular recognition site; other site 930171008551 dimerization interface [polypeptide binding]; other site 930171008552 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171008553 DNA binding residues [nucleotide binding] 930171008554 dimerization interface [polypeptide binding]; other site 930171008555 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 930171008556 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 930171008557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930171008558 Histidine kinase; Region: HisKA_3; pfam07730 930171008559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171008560 ATP binding site [chemical binding]; other site 930171008561 Mg2+ binding site [ion binding]; other site 930171008562 G-X-G motif; other site 930171008563 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171008564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171008565 active site 930171008566 phosphorylation site [posttranslational modification] 930171008567 intermolecular recognition site; other site 930171008568 dimerization interface [polypeptide binding]; other site 930171008569 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171008570 DNA binding residues [nucleotide binding] 930171008571 Acyltransferase family; Region: Acyl_transf_3; pfam01757 930171008572 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 930171008573 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 930171008574 Matrixin; Region: Peptidase_M10; pfam00413 930171008575 active site 930171008576 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 930171008577 hydrophobic ligand binding site; other site 930171008578 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171008579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171008580 active site 930171008581 phosphorylation site [posttranslational modification] 930171008582 intermolecular recognition site; other site 930171008583 dimerization interface [polypeptide binding]; other site 930171008584 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171008585 DNA binding residues [nucleotide binding] 930171008586 dimerization interface [polypeptide binding]; other site 930171008587 Histidine kinase; Region: HisKA_3; pfam07730 930171008588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171008589 ATP binding site [chemical binding]; other site 930171008590 Mg2+ binding site [ion binding]; other site 930171008591 G-X-G motif; other site 930171008592 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 930171008593 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 930171008594 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 930171008595 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 930171008596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171008597 MFS/sugar transport protein; Region: MFS_2; pfam13347 930171008598 putative substrate translocation pore; other site 930171008599 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 930171008600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171008601 Beta-lactamase; Region: Beta-lactamase; pfam00144 930171008602 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930171008603 GAF domain; Region: GAF; pfam01590 930171008604 GAF domain; Region: GAF_2; pfam13185 930171008605 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 930171008606 putative catalytic site [active] 930171008607 putative metal binding site [ion binding]; other site 930171008608 putative phosphate binding site [ion binding]; other site 930171008609 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 930171008610 active site 930171008611 catalytic triad [active] 930171008612 oxyanion hole [active] 930171008613 putative lipid kinase; Reviewed; Region: PRK13057 930171008614 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930171008615 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 930171008616 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930171008617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171008618 non-specific DNA binding site [nucleotide binding]; other site 930171008619 salt bridge; other site 930171008620 sequence-specific DNA binding site [nucleotide binding]; other site 930171008621 OsmC-like protein; Region: OsmC; pfam02566 930171008622 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930171008623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171008624 S-adenosylmethionine binding site [chemical binding]; other site 930171008625 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171008626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171008627 active site 930171008628 phosphorylation site [posttranslational modification] 930171008629 intermolecular recognition site; other site 930171008630 dimerization interface [polypeptide binding]; other site 930171008631 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171008632 DNA binding residues [nucleotide binding] 930171008633 dimerization interface [polypeptide binding]; other site 930171008634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930171008635 Histidine kinase; Region: HisKA_3; pfam07730 930171008636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171008637 ATP binding site [chemical binding]; other site 930171008638 Mg2+ binding site [ion binding]; other site 930171008639 G-X-G motif; other site 930171008640 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 930171008641 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 930171008642 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 930171008643 FOG: CBS domain [General function prediction only]; Region: COG0517 930171008644 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 930171008645 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171008646 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171008647 DNA binding site [nucleotide binding] 930171008648 domain linker motif; other site 930171008649 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 930171008650 putative dimerization interface [polypeptide binding]; other site 930171008651 putative ligand binding site [chemical binding]; other site 930171008652 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930171008653 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 930171008654 putative substrate binding site [chemical binding]; other site 930171008655 putative ATP binding site [chemical binding]; other site 930171008656 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 930171008657 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 930171008658 substrate binding [chemical binding]; other site 930171008659 active site 930171008660 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 930171008661 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171008662 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171008663 DNA binding site [nucleotide binding] 930171008664 domain linker motif; other site 930171008665 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 930171008666 putative dimerization interface [polypeptide binding]; other site 930171008667 putative ligand binding site [chemical binding]; other site 930171008668 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171008669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171008670 dimer interface [polypeptide binding]; other site 930171008671 conserved gate region; other site 930171008672 putative PBP binding loops; other site 930171008673 ABC-ATPase subunit interface; other site 930171008674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171008675 dimer interface [polypeptide binding]; other site 930171008676 conserved gate region; other site 930171008677 putative PBP binding loops; other site 930171008678 ABC-ATPase subunit interface; other site 930171008679 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171008680 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171008681 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930171008682 E3 interaction surface; other site 930171008683 lipoyl attachment site [posttranslational modification]; other site 930171008684 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 930171008685 e3 binding domain; Region: E3_binding; pfam02817 930171008686 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930171008687 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 930171008688 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 930171008689 alpha subunit interface [polypeptide binding]; other site 930171008690 TPP binding site [chemical binding]; other site 930171008691 heterodimer interface [polypeptide binding]; other site 930171008692 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930171008693 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 930171008694 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 930171008695 tetramer interface [polypeptide binding]; other site 930171008696 TPP-binding site [chemical binding]; other site 930171008697 heterodimer interface [polypeptide binding]; other site 930171008698 phosphorylation loop region [posttranslational modification] 930171008699 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930171008700 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 930171008701 putative DNA binding site [nucleotide binding]; other site 930171008702 putative Zn2+ binding site [ion binding]; other site 930171008703 AsnC family; Region: AsnC_trans_reg; pfam01037 930171008704 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 930171008705 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930171008706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 930171008707 Transposase; Region: DDE_Tnp_ISL3; pfam01610 930171008708 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 930171008709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930171008710 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 930171008711 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 930171008712 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 930171008713 NeuB family; Region: NeuB; pfam03102 930171008714 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 930171008715 ligand binding site; other site 930171008716 tetramer interface; other site 930171008717 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930171008718 Chain length determinant protein; Region: Wzz; pfam02706 930171008719 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 930171008720 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 930171008721 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 930171008722 Bacterial sugar transferase; Region: Bac_transf; pfam02397 930171008723 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 930171008724 VanZ like family; Region: VanZ; cl01971 930171008725 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 930171008726 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 930171008727 active site 930171008728 tetramer interface; other site 930171008729 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930171008730 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 930171008731 FAD binding domain; Region: FAD_binding_4; pfam01565 930171008732 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 930171008733 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 930171008734 L-lactate permease; Region: Lactate_perm; cl00701 930171008735 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930171008736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171008737 DNA-binding site [nucleotide binding]; DNA binding site 930171008738 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 930171008739 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930171008740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171008741 DNA-binding site [nucleotide binding]; DNA binding site 930171008742 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 930171008743 FAD binding domain; Region: FAD_binding_4; pfam01565 930171008744 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 930171008745 L-lactate permease; Region: Lactate_perm; cl00701 930171008746 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 930171008747 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 930171008748 malate synthase A; Region: malate_syn_A; TIGR01344 930171008749 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 930171008750 active site 930171008751 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 930171008752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930171008753 substrate binding site [chemical binding]; other site 930171008754 oxyanion hole (OAH) forming residues; other site 930171008755 trimer interface [polypeptide binding]; other site 930171008756 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 930171008757 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 930171008758 FAD binding pocket [chemical binding]; other site 930171008759 FAD binding motif [chemical binding]; other site 930171008760 phosphate binding motif [ion binding]; other site 930171008761 beta-alpha-beta structure motif; other site 930171008762 NAD(p) ribose binding residues [chemical binding]; other site 930171008763 NAD binding pocket [chemical binding]; other site 930171008764 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 930171008765 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 930171008766 catalytic loop [active] 930171008767 iron binding site [ion binding]; other site 930171008768 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 930171008769 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 930171008770 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 930171008771 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 930171008772 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 930171008773 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 930171008774 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 930171008775 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 930171008776 putative NAD(P) binding site [chemical binding]; other site 930171008777 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 930171008778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171008779 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 930171008780 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930171008781 Low molecular weight phosphatase family; Region: LMWPc; cl00105 930171008782 active site 930171008783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 930171008784 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 930171008785 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930171008786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171008787 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930171008788 Low molecular weight phosphatase family; Region: LMWPc; cd00115 930171008789 active site 930171008790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171008791 putative DNA binding site [nucleotide binding]; other site 930171008792 dimerization interface [polypeptide binding]; other site 930171008793 putative Zn2+ binding site [ion binding]; other site 930171008794 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930171008795 Low molecular weight phosphatase family; Region: LMWPc; cl00105 930171008796 active site 930171008797 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 930171008798 amphipathic channel; other site 930171008799 Asn-Pro-Ala signature motifs; other site 930171008800 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171008801 dimerization interface [polypeptide binding]; other site 930171008802 putative DNA binding site [nucleotide binding]; other site 930171008803 putative Zn2+ binding site [ion binding]; other site 930171008804 PRC-barrel domain; Region: PRC; pfam05239 930171008805 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 930171008806 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 930171008807 Cation efflux family; Region: Cation_efflux; cl00316 930171008808 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 930171008809 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 930171008810 Multicopper oxidase; Region: Cu-oxidase; pfam00394 930171008811 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 930171008812 Predicted membrane protein [Function unknown]; Region: COG3462 930171008813 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930171008814 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 930171008815 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 930171008816 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930171008817 DNA binding residues [nucleotide binding] 930171008818 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 930171008819 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 930171008820 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 930171008821 TrkA-N domain; Region: TrkA_N; pfam02254 930171008822 TrkA-C domain; Region: TrkA_C; pfam02080 930171008823 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930171008824 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 930171008825 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 930171008826 dimerization interface [polypeptide binding]; other site 930171008827 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 930171008828 Domain of unknown function (DUF305); Region: DUF305; cl17794 930171008829 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 930171008830 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 930171008831 dimerization interface [polypeptide binding]; other site 930171008832 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 930171008833 Predicted membrane protein [Function unknown]; Region: COG4325 930171008834 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171008835 dimerization interface [polypeptide binding]; other site 930171008836 putative DNA binding site [nucleotide binding]; other site 930171008837 putative Zn2+ binding site [ion binding]; other site 930171008838 H+ Antiporter protein; Region: 2A0121; TIGR00900 930171008839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 930171008840 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930171008841 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 930171008842 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 930171008843 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 930171008844 DXD motif; other site 930171008845 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930171008846 Domain of unknown function DUF21; Region: DUF21; pfam01595 930171008847 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930171008848 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930171008849 Domain of unknown function DUF21; Region: DUF21; pfam01595 930171008850 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930171008851 Transporter associated domain; Region: CorC_HlyC; smart01091 930171008852 carboxylate-amine ligase; Provisional; Region: PRK13517 930171008853 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 930171008854 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 930171008855 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 930171008856 dimerization interface [polypeptide binding]; other site 930171008857 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 930171008858 ANTAR domain; Region: ANTAR; pfam03861 930171008859 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 930171008860 GAF domain; Region: GAF_2; pfam13185 930171008861 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171008862 Predicted amidohydrolase [General function prediction only]; Region: COG0388 930171008863 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 930171008864 putative active site [active] 930171008865 catalytic triad [active] 930171008866 putative dimer interface [polypeptide binding]; other site 930171008867 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 930171008868 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 930171008869 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 930171008870 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 930171008871 D-pathway; other site 930171008872 Putative ubiquinol binding site [chemical binding]; other site 930171008873 Low-spin heme (heme b) binding site [chemical binding]; other site 930171008874 Putative water exit pathway; other site 930171008875 Binuclear center (heme o3/CuB) [ion binding]; other site 930171008876 K-pathway; other site 930171008877 Putative proton exit pathway; other site 930171008878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171008879 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 930171008880 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 930171008881 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930171008882 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930171008883 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 930171008884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930171008885 PAS fold; Region: PAS_3; pfam08447 930171008886 putative active site [active] 930171008887 heme pocket [chemical binding]; other site 930171008888 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171008889 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 930171008890 metal-binding site [ion binding] 930171008891 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 930171008892 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930171008893 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171008894 motif II; other site 930171008895 Domain of unknown function (DUF305); Region: DUF305; pfam03713 930171008896 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 930171008897 Helix-turn-helix domain; Region: HTH_38; pfam13936 930171008898 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171008899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171008900 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171008901 hypothetical protein; Provisional; Region: PRK06185 930171008902 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930171008903 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 930171008904 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930171008905 Low molecular weight phosphatase family; Region: LMWPc; cl00105 930171008906 active site 930171008907 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 930171008908 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 930171008909 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 930171008910 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930171008911 catalytic core [active] 930171008912 substrate binding site [chemical binding]; other site 930171008913 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 930171008914 ATP binding site [chemical binding]; other site 930171008915 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 930171008916 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 930171008917 putative dimer interface [polypeptide binding]; other site 930171008918 FAD binding domain; Region: FAD_binding_3; pfam01494 930171008919 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 930171008920 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 930171008921 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 930171008922 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930171008923 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 930171008924 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930171008925 active site 930171008926 CoA binding site [chemical binding]; other site 930171008927 AMP binding site [chemical binding]; other site 930171008928 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 930171008929 Acyltransferase family; Region: Acyl_transf_3; pfam01757 930171008930 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 930171008931 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 930171008932 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171008933 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 930171008934 propionate/acetate kinase; Provisional; Region: PRK12379 930171008935 phosphate acetyltransferase; Reviewed; Region: PRK05632 930171008936 DRTGG domain; Region: DRTGG; pfam07085 930171008937 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 930171008938 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 930171008939 CoenzymeA binding site [chemical binding]; other site 930171008940 subunit interaction site [polypeptide binding]; other site 930171008941 PHB binding site; other site 930171008942 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930171008943 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 930171008944 acyl-activating enzyme (AAE) consensus motif; other site 930171008945 AMP binding site [chemical binding]; other site 930171008946 active site 930171008947 CoA binding site [chemical binding]; other site 930171008948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930171008949 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 930171008950 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 930171008951 NAD(P) binding site [chemical binding]; other site 930171008952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171008953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171008954 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 930171008955 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 930171008956 protein binding site [polypeptide binding]; other site 930171008957 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930171008958 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171008959 active site 930171008960 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 930171008961 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 930171008962 substrate binding site [chemical binding]; other site 930171008963 dimer interface [polypeptide binding]; other site 930171008964 NADP binding site [chemical binding]; other site 930171008965 catalytic residues [active] 930171008966 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 930171008967 active site 2 [active] 930171008968 active site 1 [active] 930171008969 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 930171008970 CoenzymeA binding site [chemical binding]; other site 930171008971 subunit interaction site [polypeptide binding]; other site 930171008972 PHB binding site; other site 930171008973 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 930171008974 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 930171008975 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 930171008976 active site 930171008977 catalytic triad [active] 930171008978 oxyanion hole [active] 930171008979 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930171008980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930171008981 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 930171008982 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 930171008983 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 930171008984 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 930171008985 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930171008986 substrate binding site [chemical binding]; other site 930171008987 oxyanion hole (OAH) forming residues; other site 930171008988 trimer interface [polypeptide binding]; other site 930171008989 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 930171008990 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930171008991 dimer interface [polypeptide binding]; other site 930171008992 active site 930171008993 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 930171008994 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 930171008995 hydrophobic ligand binding site; other site 930171008996 CsbD-like; Region: CsbD; pfam05532 930171008997 DNA polymerase IV; Validated; Region: PRK03352 930171008998 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 930171008999 active site 930171009000 DNA binding site [nucleotide binding] 930171009001 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 930171009002 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 930171009003 iron-sulfur cluster [ion binding]; other site 930171009004 [2Fe-2S] cluster binding site [ion binding]; other site 930171009005 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 930171009006 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171009007 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 930171009008 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 930171009009 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 930171009010 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930171009011 dimer interface [polypeptide binding]; other site 930171009012 putative PBP binding regions; other site 930171009013 ABC-ATPase subunit interface; other site 930171009014 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 930171009015 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 930171009016 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 930171009017 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 930171009018 metal binding site [ion binding]; metal-binding site 930171009019 CAAX protease self-immunity; Region: Abi; pfam02517 930171009020 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 930171009021 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930171009022 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 930171009023 substrate binding site [chemical binding]; other site 930171009024 oxyanion hole (OAH) forming residues; other site 930171009025 trimer interface [polypeptide binding]; other site 930171009026 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930171009027 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930171009028 acyl-activating enzyme (AAE) consensus motif; other site 930171009029 acyl-activating enzyme (AAE) consensus motif; other site 930171009030 active site 930171009031 AMP binding site [chemical binding]; other site 930171009032 CoA binding site [chemical binding]; other site 930171009033 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 930171009034 UbiA prenyltransferase family; Region: UbiA; pfam01040 930171009035 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 930171009036 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 930171009037 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 930171009038 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 930171009039 Dynamin family; Region: Dynamin_N; pfam00350 930171009040 G1 box; other site 930171009041 G1 box; other site 930171009042 GTP/Mg2+ binding site [chemical binding]; other site 930171009043 GTP/Mg2+ binding site [chemical binding]; other site 930171009044 G2 box; other site 930171009045 Switch I region; other site 930171009046 G3 box; other site 930171009047 Switch II region; other site 930171009048 G4 box; other site 930171009049 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 930171009050 Dynamin family; Region: Dynamin_N; pfam00350 930171009051 G1 box; other site 930171009052 GTP/Mg2+ binding site [chemical binding]; other site 930171009053 G2 box; other site 930171009054 Switch I region; other site 930171009055 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 930171009056 G3 box; other site 930171009057 Switch II region; other site 930171009058 GTP/Mg2+ binding site [chemical binding]; other site 930171009059 G4 box; other site 930171009060 G5 box; other site 930171009061 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171009062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171009063 DNA binding residues [nucleotide binding] 930171009064 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 930171009065 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 930171009066 nucleotide binding site [chemical binding]; other site 930171009067 putative NEF/HSP70 interaction site [polypeptide binding]; other site 930171009068 SBD interface [polypeptide binding]; other site 930171009069 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 930171009070 ResB-like family; Region: ResB; pfam05140 930171009071 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 930171009072 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 930171009073 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 930171009074 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 930171009075 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930171009076 catalytic residues [active] 930171009077 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930171009078 catalytic core [active] 930171009079 Uncharacterized conserved protein [Function unknown]; Region: COG2353 930171009080 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 930171009081 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 930171009082 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 930171009083 CoA binding domain; Region: CoA_binding; pfam02629 930171009084 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 930171009085 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 930171009086 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930171009087 DNA binding domain, excisionase family; Region: excise; TIGR01764 930171009088 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 930171009089 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 930171009090 glucuronide transporter; Provisional; Region: PRK09848 930171009091 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 930171009092 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 930171009093 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 930171009094 N- and C-terminal domain interface [polypeptide binding]; other site 930171009095 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 930171009096 active site 930171009097 putative catalytic site [active] 930171009098 metal binding site [ion binding]; metal-binding site 930171009099 ATP binding site [chemical binding]; other site 930171009100 carbohydrate binding site [chemical binding]; other site 930171009101 short chain dehydrogenase; Validated; Region: PRK08324 930171009102 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 930171009103 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 930171009104 putative NAD(P) binding site [chemical binding]; other site 930171009105 active site 930171009106 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 930171009107 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 930171009108 Domain of unknown function (DUF718); Region: DUF718; pfam05336 930171009109 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171009110 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171009111 DNA binding site [nucleotide binding] 930171009112 domain linker motif; other site 930171009113 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171009114 dimerization interface [polypeptide binding]; other site 930171009115 ligand binding site [chemical binding]; other site 930171009116 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 930171009117 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 930171009118 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 930171009119 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 930171009120 active site 930171009121 catalytic triad [active] 930171009122 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171009123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009124 dimer interface [polypeptide binding]; other site 930171009125 conserved gate region; other site 930171009126 putative PBP binding loops; other site 930171009127 ABC-ATPase subunit interface; other site 930171009128 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 930171009129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009130 dimer interface [polypeptide binding]; other site 930171009131 conserved gate region; other site 930171009132 ABC-ATPase subunit interface; other site 930171009133 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171009134 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171009135 Protein of unknown function, DUF624; Region: DUF624; cl02369 930171009136 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171009137 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171009138 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 930171009139 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 930171009140 Transmembrane secretion effector; Region: MFS_3; pfam05977 930171009141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171009142 putative substrate translocation pore; other site 930171009143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930171009144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009145 dimer interface [polypeptide binding]; other site 930171009146 putative PBP binding loops; other site 930171009147 ABC-ATPase subunit interface; other site 930171009148 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171009149 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171009150 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 930171009151 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 930171009152 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 930171009153 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 930171009154 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171009155 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171009156 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171009157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009158 dimer interface [polypeptide binding]; other site 930171009159 conserved gate region; other site 930171009160 putative PBP binding loops; other site 930171009161 ABC-ATPase subunit interface; other site 930171009162 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 930171009163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009164 dimer interface [polypeptide binding]; other site 930171009165 putative PBP binding loops; other site 930171009166 ABC-ATPase subunit interface; other site 930171009167 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171009168 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171009169 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 930171009170 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171009171 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171009172 Methane oxygenase PmoA; Region: PmoA; pfam14100 930171009173 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 930171009174 active site 930171009175 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 930171009176 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 930171009177 dimer interface [polypeptide binding]; other site 930171009178 NADP binding site [chemical binding]; other site 930171009179 catalytic residues [active] 930171009180 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 930171009181 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 930171009182 active site pocket [active] 930171009183 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 930171009184 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 930171009185 catalytic residue [active] 930171009186 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930171009187 extended (e) SDRs; Region: SDR_e; cd08946 930171009188 NAD(P) binding site [chemical binding]; other site 930171009189 active site 930171009190 substrate binding site [chemical binding]; other site 930171009191 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171009192 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171009193 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171009194 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171009195 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171009196 DNA binding site [nucleotide binding] 930171009197 domain linker motif; other site 930171009198 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171009199 dimerization interface [polypeptide binding]; other site 930171009200 ligand binding site [chemical binding]; other site 930171009201 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930171009202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171009203 DNA-binding site [nucleotide binding]; DNA binding site 930171009204 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 930171009205 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 930171009206 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 930171009207 phosphate binding site [ion binding]; other site 930171009208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171009209 dimerization interface [polypeptide binding]; other site 930171009210 putative DNA binding site [nucleotide binding]; other site 930171009211 putative Zn2+ binding site [ion binding]; other site 930171009212 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 930171009213 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 930171009214 active site 930171009215 Zn binding site [ion binding]; other site 930171009216 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 930171009217 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 930171009218 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 930171009219 TrkA-N domain; Region: TrkA_N; pfam02254 930171009220 TrkA-C domain; Region: TrkA_C; pfam02080 930171009221 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 930171009222 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 930171009223 exopolyphosphatase; Region: exo_poly_only; TIGR03706 930171009224 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 930171009225 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 930171009226 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 930171009227 active site 930171009228 interdomain interaction site; other site 930171009229 putative metal-binding site [ion binding]; other site 930171009230 nucleotide binding site [chemical binding]; other site 930171009231 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 930171009232 domain I; other site 930171009233 DNA binding groove [nucleotide binding] 930171009234 phosphate binding site [ion binding]; other site 930171009235 domain II; other site 930171009236 domain III; other site 930171009237 nucleotide binding site [chemical binding]; other site 930171009238 catalytic site [active] 930171009239 domain IV; other site 930171009240 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 930171009241 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 930171009242 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 930171009243 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 930171009244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171009245 S-adenosylmethionine binding site [chemical binding]; other site 930171009246 hypothetical protein; Validated; Region: PRK01415 930171009247 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 930171009248 active site residue [active] 930171009249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 930171009250 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 930171009251 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171009252 ATP binding site [chemical binding]; other site 930171009253 putative Mg++ binding site [ion binding]; other site 930171009254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171009255 nucleotide binding region [chemical binding]; other site 930171009256 ATP-binding site [chemical binding]; other site 930171009257 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 930171009258 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 930171009259 Type II/IV secretion system protein; Region: T2SE; pfam00437 930171009260 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 930171009261 ATP binding site [chemical binding]; other site 930171009262 Walker A motif; other site 930171009263 hexamer interface [polypeptide binding]; other site 930171009264 Walker B motif; other site 930171009265 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 930171009266 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 930171009267 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 930171009268 active site 930171009269 DNA binding site [nucleotide binding] 930171009270 catalytic site [active] 930171009271 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 930171009272 putative active site [active] 930171009273 putative CoA binding site [chemical binding]; other site 930171009274 nudix motif; other site 930171009275 metal binding site [ion binding]; metal-binding site 930171009276 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 930171009277 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 930171009278 minor groove reading motif; other site 930171009279 helix-hairpin-helix signature motif; other site 930171009280 substrate binding pocket [chemical binding]; other site 930171009281 active site 930171009282 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 930171009283 acetyl-CoA synthetase; Provisional; Region: PRK00174 930171009284 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 930171009285 active site 930171009286 CoA binding site [chemical binding]; other site 930171009287 acyl-activating enzyme (AAE) consensus motif; other site 930171009288 AMP binding site [chemical binding]; other site 930171009289 acetate binding site [chemical binding]; other site 930171009290 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930171009291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171009292 DNA-binding site [nucleotide binding]; DNA binding site 930171009293 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930171009294 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171009295 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171009296 DNA binding site [nucleotide binding] 930171009297 domain linker motif; other site 930171009298 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 930171009299 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 930171009300 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 930171009301 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 930171009302 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 930171009303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009304 dimer interface [polypeptide binding]; other site 930171009305 conserved gate region; other site 930171009306 ABC-ATPase subunit interface; other site 930171009307 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171009308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009309 dimer interface [polypeptide binding]; other site 930171009310 conserved gate region; other site 930171009311 putative PBP binding loops; other site 930171009312 ABC-ATPase subunit interface; other site 930171009313 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171009314 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171009315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171009316 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171009317 DNA binding site [nucleotide binding] 930171009318 domain linker motif; other site 930171009319 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171009320 dimerization interface [polypeptide binding]; other site 930171009321 ligand binding site [chemical binding]; other site 930171009322 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171009323 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171009324 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 930171009325 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171009326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009327 dimer interface [polypeptide binding]; other site 930171009328 conserved gate region; other site 930171009329 putative PBP binding loops; other site 930171009330 ABC-ATPase subunit interface; other site 930171009331 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171009332 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171009333 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 930171009334 Melibiase; Region: Melibiase; pfam02065 930171009335 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 930171009336 Dehydroquinase class II; Region: DHquinase_II; pfam01220 930171009337 trimer interface [polypeptide binding]; other site 930171009338 active site 930171009339 dimer interface [polypeptide binding]; other site 930171009340 Colicin V production protein; Region: Colicin_V; pfam02674 930171009341 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 930171009342 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 930171009343 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930171009344 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930171009345 ligand binding site [chemical binding]; other site 930171009346 flexible hinge region; other site 930171009347 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 930171009348 putative switch regulator; other site 930171009349 non-specific DNA interactions [nucleotide binding]; other site 930171009350 DNA binding site [nucleotide binding] 930171009351 sequence specific DNA binding site [nucleotide binding]; other site 930171009352 putative cAMP binding site [chemical binding]; other site 930171009353 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 930171009354 homotrimer interaction site [polypeptide binding]; other site 930171009355 putative active site [active] 930171009356 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 930171009357 Transglycosylase; Region: Transgly; pfam00912 930171009358 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 930171009359 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 930171009360 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 930171009361 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930171009362 putative active site [active] 930171009363 putative metal binding site [ion binding]; other site 930171009364 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930171009365 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930171009366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171009367 Walker A/P-loop; other site 930171009368 ATP binding site [chemical binding]; other site 930171009369 Q-loop/lid; other site 930171009370 ABC transporter signature motif; other site 930171009371 Walker B; other site 930171009372 D-loop; other site 930171009373 H-loop/switch region; other site 930171009374 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930171009375 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930171009376 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 930171009377 Walker A/P-loop; other site 930171009378 ATP binding site [chemical binding]; other site 930171009379 Q-loop/lid; other site 930171009380 ABC transporter signature motif; other site 930171009381 Walker B; other site 930171009382 D-loop; other site 930171009383 H-loop/switch region; other site 930171009384 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930171009385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171009386 non-specific DNA binding site [nucleotide binding]; other site 930171009387 salt bridge; other site 930171009388 sequence-specific DNA binding site [nucleotide binding]; other site 930171009389 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 930171009390 ATP binding site [chemical binding]; other site 930171009391 active site 930171009392 substrate binding site [chemical binding]; other site 930171009393 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 930171009394 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 930171009395 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 930171009396 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 930171009397 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 930171009398 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 930171009399 Moco binding site; other site 930171009400 metal coordination site [ion binding]; other site 930171009401 L-asparaginase II; Region: Asparaginase_II; pfam06089 930171009402 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930171009403 active site 930171009404 metal binding site [ion binding]; metal-binding site 930171009405 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171009406 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 930171009407 classical (c) SDRs; Region: SDR_c; cd05233 930171009408 NAD(P) binding site [chemical binding]; other site 930171009409 active site 930171009410 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 930171009411 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 930171009412 Na binding site [ion binding]; other site 930171009413 putative substrate binding site [chemical binding]; other site 930171009414 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 930171009415 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 930171009416 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 930171009417 Na binding site [ion binding]; other site 930171009418 putative substrate binding site [chemical binding]; other site 930171009419 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 930171009420 Ligand binding site; other site 930171009421 metal-binding site 930171009422 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 930171009423 ligand binding site [chemical binding]; other site 930171009424 active site 930171009425 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171009426 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171009427 active site 930171009428 catalytic tetrad [active] 930171009429 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 930171009430 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 930171009431 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 930171009432 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 930171009433 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 930171009434 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 930171009435 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 930171009436 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 930171009437 XdhC Rossmann domain; Region: XdhC_C; pfam13478 930171009438 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930171009439 benzoate transporter; Region: benE; TIGR00843 930171009440 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 930171009441 nucleoside/Zn binding site; other site 930171009442 dimer interface [polypeptide binding]; other site 930171009443 catalytic motif [active] 930171009444 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 930171009445 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 930171009446 active site 930171009447 putative substrate binding pocket [chemical binding]; other site 930171009448 urate oxidase; Region: urate_oxi; TIGR03383 930171009449 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 930171009450 active site 930171009451 xanthine permease; Region: pbuX; TIGR03173 930171009452 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 930171009453 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171009454 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171009455 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 930171009456 Malic enzyme, N-terminal domain; Region: malic; pfam00390 930171009457 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 930171009458 putative NAD(P) binding site [chemical binding]; other site 930171009459 malate synthase A; Region: malate_syn_A; TIGR01344 930171009460 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 930171009461 active site 930171009462 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 930171009463 hypothetical protein; Provisional; Region: PRK11171 930171009464 Cupin domain; Region: Cupin_2; cl17218 930171009465 Cupin domain; Region: Cupin_2; pfam07883 930171009466 Beta-lactamase; Region: Beta-lactamase; pfam00144 930171009467 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930171009468 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 930171009469 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930171009470 NAD binding site [chemical binding]; other site 930171009471 catalytic Zn binding site [ion binding]; other site 930171009472 structural Zn binding site [ion binding]; other site 930171009473 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 930171009474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930171009475 motif II; other site 930171009476 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 930171009477 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 930171009478 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 930171009479 Protein of unknown function DUF72; Region: DUF72; pfam01904 930171009480 Uncharacterized conserved protein [Function unknown]; Region: COG4850 930171009481 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 930171009482 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 930171009483 beta-galactosidase; Region: BGL; TIGR03356 930171009484 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 930171009485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171009486 Walker A motif; other site 930171009487 ATP binding site [chemical binding]; other site 930171009488 Walker B motif; other site 930171009489 arginine finger; other site 930171009490 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 930171009491 HSP70 interaction site [polypeptide binding]; other site 930171009492 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 930171009493 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 930171009494 putative dimer interface [polypeptide binding]; other site 930171009495 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 930171009496 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930171009497 DNA binding residues [nucleotide binding] 930171009498 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 930171009499 active site 930171009500 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 930171009501 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 930171009502 calcium binding site 2 [ion binding]; other site 930171009503 active site 930171009504 catalytic triad [active] 930171009505 calcium binding site 1 [ion binding]; other site 930171009506 Bacterial Ig-like domain; Region: Big_5; pfam13205 930171009507 Bacterial Ig-like domain; Region: Big_5; pfam13205 930171009508 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930171009509 extended (e) SDRs; Region: SDR_e; cd08946 930171009510 NAD(P) binding site [chemical binding]; other site 930171009511 active site 930171009512 substrate binding site [chemical binding]; other site 930171009513 adenylate kinase; Reviewed; Region: adk; PRK00279 930171009514 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 930171009515 AMP-binding site [chemical binding]; other site 930171009516 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 930171009517 GAF domain; Region: GAF; pfam01590 930171009518 GAF domain; Region: GAF_2; pfam13185 930171009519 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171009520 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930171009521 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930171009522 TAP-like protein; Region: Abhydrolase_4; pfam08386 930171009523 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 930171009524 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 930171009525 putative di-iron ligands [ion binding]; other site 930171009526 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 930171009527 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 930171009528 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 930171009529 FAD binding pocket [chemical binding]; other site 930171009530 FAD binding motif [chemical binding]; other site 930171009531 phosphate binding motif [ion binding]; other site 930171009532 beta-alpha-beta structure motif; other site 930171009533 NAD binding pocket [chemical binding]; other site 930171009534 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 930171009535 catalytic loop [active] 930171009536 iron binding site [ion binding]; other site 930171009537 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 930171009538 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 930171009539 hypothetical protein; Provisional; Region: PRK02237 930171009540 Predicted dehydrogenase [General function prediction only]; Region: COG0579 930171009541 hydroxyglutarate oxidase; Provisional; Region: PRK11728 930171009542 Domain of unknown function (DUF202); Region: DUF202; cl09954 930171009543 Domain of unknown function (DUF202); Region: DUF202; pfam02656 930171009544 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 930171009545 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 930171009546 Predicted amidohydrolase [General function prediction only]; Region: COG0388 930171009547 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 930171009548 putative active site [active] 930171009549 catalytic triad [active] 930171009550 putative dimer interface [polypeptide binding]; other site 930171009551 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 930171009552 Predicted transcriptional regulators [Transcription]; Region: COG1695 930171009553 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930171009554 Transglycosylase; Region: Transgly; pfam00912 930171009555 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 930171009556 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 930171009557 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930171009558 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930171009559 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 930171009560 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 930171009561 CoenzymeA binding site [chemical binding]; other site 930171009562 subunit interaction site [polypeptide binding]; other site 930171009563 PHB binding site; other site 930171009564 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 930171009565 putative hydrophobic ligand binding site [chemical binding]; other site 930171009566 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171009567 dimerization interface [polypeptide binding]; other site 930171009568 putative DNA binding site [nucleotide binding]; other site 930171009569 putative Zn2+ binding site [ion binding]; other site 930171009570 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 930171009571 conserved cys residue [active] 930171009572 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171009573 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171009574 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 930171009575 GAF domain; Region: GAF_2; pfam13185 930171009576 ANTAR domain; Region: ANTAR; pfam03861 930171009577 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 930171009578 GAF domain; Region: GAF; pfam01590 930171009579 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171009580 GAF domain; Region: GAF_2; pfam13185 930171009581 ANTAR domain; Region: ANTAR; pfam03861 930171009582 GAF domain; Region: GAF; cl17456 930171009583 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 930171009584 Nitronate monooxygenase; Region: NMO; pfam03060 930171009585 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 930171009586 FMN binding site [chemical binding]; other site 930171009587 substrate binding site [chemical binding]; other site 930171009588 putative catalytic residue [active] 930171009589 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 930171009590 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 930171009591 putative NAD(P) binding site [chemical binding]; other site 930171009592 putative substrate binding site [chemical binding]; other site 930171009593 catalytic Zn binding site [ion binding]; other site 930171009594 structural Zn binding site [ion binding]; other site 930171009595 dimer interface [polypeptide binding]; other site 930171009596 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930171009597 dimer interface [polypeptide binding]; other site 930171009598 Protein of unknown function (DUF817); Region: DUF817; pfam05675 930171009599 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 930171009600 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 930171009601 putative binding surface; other site 930171009602 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 930171009603 active site 930171009604 metal binding site [ion binding]; metal-binding site 930171009605 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 930171009606 putative active site [active] 930171009607 catalytic site [active] 930171009608 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 930171009609 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171009610 Ligand Binding Site [chemical binding]; other site 930171009611 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 930171009612 FAD binding site [chemical binding]; other site 930171009613 lipoyl synthase; Provisional; Region: PRK05481 930171009614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930171009615 FeS/SAM binding site; other site 930171009616 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 930171009617 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 930171009618 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 930171009619 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 930171009620 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 930171009621 dimer interface [polypeptide binding]; other site 930171009622 active site 930171009623 glycine-pyridoxal phosphate binding site [chemical binding]; other site 930171009624 folate binding site [chemical binding]; other site 930171009625 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 930171009626 lipoyl attachment site [posttranslational modification]; other site 930171009627 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 930171009628 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 930171009629 glycine dehydrogenase; Provisional; Region: PRK05367 930171009630 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 930171009631 tetramer interface [polypeptide binding]; other site 930171009632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171009633 catalytic residue [active] 930171009634 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 930171009635 tetramer interface [polypeptide binding]; other site 930171009636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171009637 catalytic residue [active] 930171009638 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930171009639 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930171009640 active site 930171009641 metal binding site [ion binding]; metal-binding site 930171009642 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 930171009643 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 930171009644 calcium binding site 2 [ion binding]; other site 930171009645 active site 930171009646 catalytic triad [active] 930171009647 calcium binding site 1 [ion binding]; other site 930171009648 Domain of unknown function (DUF427); Region: DUF427; pfam04248 930171009649 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 930171009650 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 930171009651 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171009652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009653 dimer interface [polypeptide binding]; other site 930171009654 conserved gate region; other site 930171009655 putative PBP binding loops; other site 930171009656 ABC-ATPase subunit interface; other site 930171009657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009658 putative PBP binding loops; other site 930171009659 dimer interface [polypeptide binding]; other site 930171009660 ABC-ATPase subunit interface; other site 930171009661 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171009662 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 930171009663 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171009664 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171009665 DNA binding site [nucleotide binding] 930171009666 domain linker motif; other site 930171009667 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171009668 dimerization interface [polypeptide binding]; other site 930171009669 ligand binding site [chemical binding]; other site 930171009670 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 930171009671 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 930171009672 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930171009673 active site residue [active] 930171009674 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 930171009675 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 930171009676 Flavodoxin domain; Region: Flavodoxin_5; cl17428 930171009677 potential frameshift: common BLAST hit: gi|220910993|ref|YP_002486302.1| peptidase metallopeptidase 930171009678 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 930171009679 active site 930171009680 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 930171009681 putative hydrophobic ligand binding site [chemical binding]; other site 930171009682 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930171009683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171009684 Coenzyme A binding pocket [chemical binding]; other site 930171009685 Domain of unknown function (DUF222); Region: DUF222; pfam02720 930171009686 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171009687 active site 930171009688 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 930171009689 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 930171009690 Cobalt transport protein; Region: CbiQ; cl00463 930171009691 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 930171009692 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930171009693 Walker A/P-loop; other site 930171009694 ATP binding site [chemical binding]; other site 930171009695 Q-loop/lid; other site 930171009696 ABC transporter signature motif; other site 930171009697 Walker B; other site 930171009698 D-loop; other site 930171009699 H-loop/switch region; other site 930171009700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171009701 Walker A/P-loop; other site 930171009702 ATP binding site [chemical binding]; other site 930171009703 Q-loop/lid; other site 930171009704 ABC transporter signature motif; other site 930171009705 Walker B; other site 930171009706 D-loop; other site 930171009707 H-loop/switch region; other site 930171009708 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 930171009709 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 930171009710 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 930171009711 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 930171009712 NAD binding site [chemical binding]; other site 930171009713 catalytic Zn binding site [ion binding]; other site 930171009714 structural Zn binding site [ion binding]; other site 930171009715 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 930171009716 Amidohydrolase; Region: Amidohydro_2; pfam04909 930171009717 active site 930171009718 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171009719 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171009720 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171009721 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171009722 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171009723 enoyl-CoA hydratase; Provisional; Region: PRK06144 930171009724 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930171009725 substrate binding site [chemical binding]; other site 930171009726 oxyanion hole (OAH) forming residues; other site 930171009727 trimer interface [polypeptide binding]; other site 930171009728 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 930171009729 CoA-transferase family III; Region: CoA_transf_3; pfam02515 930171009730 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171009731 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171009732 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171009733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009734 dimer interface [polypeptide binding]; other site 930171009735 conserved gate region; other site 930171009736 putative PBP binding loops; other site 930171009737 ABC-ATPase subunit interface; other site 930171009738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009739 dimer interface [polypeptide binding]; other site 930171009740 conserved gate region; other site 930171009741 putative PBP binding loops; other site 930171009742 ABC-ATPase subunit interface; other site 930171009743 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930171009744 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 930171009745 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 930171009746 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930171009747 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 930171009748 tetramerization interface [polypeptide binding]; other site 930171009749 NAD(P) binding site [chemical binding]; other site 930171009750 catalytic residues [active] 930171009751 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 930171009752 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 930171009753 active site 930171009754 NAD binding site [chemical binding]; other site 930171009755 metal binding site [ion binding]; metal-binding site 930171009756 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930171009757 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171009758 DNA-binding site [nucleotide binding]; DNA binding site 930171009759 FCD domain; Region: FCD; pfam07729 930171009760 Cupin domain; Region: Cupin_2; pfam07883 930171009761 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171009762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171009763 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171009764 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 930171009765 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 930171009766 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 930171009767 substrate binding pocket [chemical binding]; other site 930171009768 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 930171009769 B12 binding site [chemical binding]; other site 930171009770 cobalt ligand [ion binding]; other site 930171009771 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 930171009772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 930171009773 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 930171009774 Integrase core domain; Region: rve; pfam00665 930171009775 transposase; Provisional; Region: PRK06526 930171009776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171009777 Walker A motif; other site 930171009778 ATP binding site [chemical binding]; other site 930171009779 Walker B motif; other site 930171009780 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 930171009781 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 930171009782 active site 930171009783 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 930171009784 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 930171009785 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930171009786 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 930171009787 Walker A/P-loop; other site 930171009788 ATP binding site [chemical binding]; other site 930171009789 Q-loop/lid; other site 930171009790 ABC transporter signature motif; other site 930171009791 Walker B; other site 930171009792 D-loop; other site 930171009793 H-loop/switch region; other site 930171009794 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930171009795 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930171009796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171009797 Walker A/P-loop; other site 930171009798 ATP binding site [chemical binding]; other site 930171009799 Q-loop/lid; other site 930171009800 ABC transporter signature motif; other site 930171009801 Walker B; other site 930171009802 D-loop; other site 930171009803 H-loop/switch region; other site 930171009804 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 930171009805 Predicted amidohydrolase [General function prediction only]; Region: COG0388 930171009806 putative active site [active] 930171009807 catalytic triad [active] 930171009808 putative dimer interface [polypeptide binding]; other site 930171009809 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171009810 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171009811 DNA binding site [nucleotide binding] 930171009812 domain linker motif; other site 930171009813 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 930171009814 ligand binding site [chemical binding]; other site 930171009815 dimerization interface (open form) [polypeptide binding]; other site 930171009816 dimerization interface (closed form) [polypeptide binding]; other site 930171009817 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 930171009818 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 930171009819 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 930171009820 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171009821 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171009822 active site 930171009823 catalytic tetrad [active] 930171009824 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930171009825 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 930171009826 TM-ABC transporter signature motif; other site 930171009827 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 930171009828 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930171009829 Walker A/P-loop; other site 930171009830 ATP binding site [chemical binding]; other site 930171009831 Q-loop/lid; other site 930171009832 ABC transporter signature motif; other site 930171009833 Walker B; other site 930171009834 D-loop; other site 930171009835 H-loop/switch region; other site 930171009836 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930171009837 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 930171009838 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 930171009839 ligand binding site [chemical binding]; other site 930171009840 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930171009841 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930171009842 nucleotide binding site [chemical binding]; other site 930171009843 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930171009844 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171009845 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 930171009846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009847 dimer interface [polypeptide binding]; other site 930171009848 conserved gate region; other site 930171009849 putative PBP binding loops; other site 930171009850 ABC-ATPase subunit interface; other site 930171009851 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171009852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171009853 dimer interface [polypeptide binding]; other site 930171009854 conserved gate region; other site 930171009855 putative PBP binding loops; other site 930171009856 ABC-ATPase subunit interface; other site 930171009857 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 930171009858 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 930171009859 active site 930171009860 catalytic site [active] 930171009861 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930171009862 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930171009863 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171009864 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171009865 DNA binding site [nucleotide binding] 930171009866 domain linker motif; other site 930171009867 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 930171009868 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 930171009869 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 930171009870 inhibitor site; inhibition site 930171009871 active site 930171009872 dimer interface [polypeptide binding]; other site 930171009873 catalytic residue [active] 930171009874 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 930171009875 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 930171009876 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 930171009877 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 930171009878 dimer interface [polypeptide binding]; other site 930171009879 active site 930171009880 heme binding site [chemical binding]; other site 930171009881 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 930171009882 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 930171009883 nucleoside/Zn binding site; other site 930171009884 dimer interface [polypeptide binding]; other site 930171009885 catalytic motif [active] 930171009886 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 930171009887 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 930171009888 hypothetical protein; Provisional; Region: PRK12764 930171009889 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930171009890 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 930171009891 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930171009892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171009893 DNA-binding site [nucleotide binding]; DNA binding site 930171009894 FCD domain; Region: FCD; pfam07729 930171009895 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 930171009896 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 930171009897 NAD binding site [chemical binding]; other site 930171009898 catalytic residues [active] 930171009899 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 930171009900 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 930171009901 tetramer interface [polypeptide binding]; other site 930171009902 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 930171009903 tetramer interface [polypeptide binding]; other site 930171009904 active site 930171009905 metal binding site [ion binding]; metal-binding site 930171009906 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 930171009907 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 930171009908 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171009909 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171009910 active site 930171009911 catalytic tetrad [active] 930171009912 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 930171009913 active site 930171009914 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 930171009915 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 930171009916 benzoate transport; Region: 2A0115; TIGR00895 930171009917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171009918 putative substrate translocation pore; other site 930171009919 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 930171009920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171009921 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 930171009922 dimerization interface [polypeptide binding]; other site 930171009923 substrate binding pocket [chemical binding]; other site 930171009924 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 930171009925 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 930171009926 active site 930171009927 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 930171009928 AAA ATPase domain; Region: AAA_16; pfam13191 930171009929 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171009930 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171009931 DNA binding residues [nucleotide binding] 930171009932 dimerization interface [polypeptide binding]; other site 930171009933 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 930171009934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171009935 NAD(P) binding site [chemical binding]; other site 930171009936 active site 930171009937 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 930171009938 inter-subunit interface; other site 930171009939 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 930171009940 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 930171009941 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 930171009942 putative alpha subunit interface [polypeptide binding]; other site 930171009943 putative active site [active] 930171009944 putative substrate binding site [chemical binding]; other site 930171009945 Fe binding site [ion binding]; other site 930171009946 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 930171009947 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 930171009948 active site 930171009949 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 930171009950 benzoate transporter; Region: benE; TIGR00843 930171009951 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 930171009952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171009953 putative substrate translocation pore; other site 930171009954 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 930171009955 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 930171009956 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 930171009957 4Fe-4S binding domain; Region: Fer4; cl02805 930171009958 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 930171009959 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 930171009960 [4Fe-4S] binding site [ion binding]; other site 930171009961 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 930171009962 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 930171009963 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 930171009964 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 930171009965 molybdopterin cofactor binding site; other site 930171009966 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 930171009967 A new structural DNA glycosylase; Region: AlkD_like; cd06561 930171009968 active site 930171009969 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930171009970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171009971 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 930171009972 putative dimerization interface [polypeptide binding]; other site 930171009973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 930171009974 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 930171009975 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 930171009976 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171009977 Ligand Binding Site [chemical binding]; other site 930171009978 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 930171009979 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 930171009980 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171009981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171009982 active site 930171009983 phosphorylation site [posttranslational modification] 930171009984 intermolecular recognition site; other site 930171009985 dimerization interface [polypeptide binding]; other site 930171009986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171009987 DNA binding residues [nucleotide binding] 930171009988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930171009989 Histidine kinase; Region: HisKA_3; pfam07730 930171009990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171009991 ATP binding site [chemical binding]; other site 930171009992 Mg2+ binding site [ion binding]; other site 930171009993 G-X-G motif; other site 930171009994 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930171009995 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930171009996 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930171009997 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930171009998 Walker A/P-loop; other site 930171009999 ATP binding site [chemical binding]; other site 930171010000 Q-loop/lid; other site 930171010001 ABC transporter signature motif; other site 930171010002 Walker B; other site 930171010003 D-loop; other site 930171010004 H-loop/switch region; other site 930171010005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171010006 ATP binding site [chemical binding]; other site 930171010007 Mg2+ binding site [ion binding]; other site 930171010008 G-X-G motif; other site 930171010009 Predicted flavoprotein [General function prediction only]; Region: COG0431 930171010010 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930171010011 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 930171010012 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 930171010013 putative hydrophobic ligand binding site [chemical binding]; other site 930171010014 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 930171010015 putative hydrophobic ligand binding site [chemical binding]; other site 930171010016 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 930171010017 metal binding site [ion binding]; metal-binding site 930171010018 active site 930171010019 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930171010020 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 930171010021 AsnC family; Region: AsnC_trans_reg; pfam01037 930171010022 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 930171010023 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171010024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171010025 homodimer interface [polypeptide binding]; other site 930171010026 catalytic residue [active] 930171010027 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930171010028 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 930171010029 threonine dehydratase; Provisional; Region: PRK08246 930171010030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930171010031 catalytic residue [active] 930171010032 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 930171010033 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 930171010034 active site 930171010035 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930171010036 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171010037 DNA-binding site [nucleotide binding]; DNA binding site 930171010038 UTRA domain; Region: UTRA; pfam07702 930171010039 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 930171010040 HPr interaction site; other site 930171010041 glycerol kinase (GK) interaction site [polypeptide binding]; other site 930171010042 active site 930171010043 phosphorylation site [posttranslational modification] 930171010044 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930171010045 active site turn [active] 930171010046 phosphorylation site [posttranslational modification] 930171010047 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930171010048 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 930171010049 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 930171010050 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 930171010051 active site 930171010052 trimer interface [polypeptide binding]; other site 930171010053 allosteric site; other site 930171010054 active site lid [active] 930171010055 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930171010056 CutC family; Region: CutC; cl01218 930171010057 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930171010058 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 930171010059 active site 930171010060 Domain of unknown function (DUF222); Region: DUF222; pfam02720 930171010061 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171010062 active site 930171010063 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 930171010064 iron-sulfur cluster [ion binding]; other site 930171010065 [2Fe-2S] cluster binding site [ion binding]; other site 930171010066 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930171010067 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 930171010068 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 930171010069 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 930171010070 Amidase; Region: Amidase; cl11426 930171010071 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 930171010072 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 930171010073 AsnC family; Region: AsnC_trans_reg; pfam01037 930171010074 MarR family; Region: MarR_2; pfam12802 930171010075 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930171010076 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930171010077 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 930171010078 metal binding site [ion binding]; metal-binding site 930171010079 dimer interface [polypeptide binding]; other site 930171010080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010081 metabolite-proton symporter; Region: 2A0106; TIGR00883 930171010082 putative substrate translocation pore; other site 930171010083 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930171010084 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171010085 dimerization interface [polypeptide binding]; other site 930171010086 putative Zn2+ binding site [ion binding]; other site 930171010087 putative DNA binding site [nucleotide binding]; other site 930171010088 Domain of unknown function (DUF897); Region: DUF897; cl01312 930171010089 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 930171010090 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 930171010091 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930171010092 glyoxylate carboligase; Provisional; Region: PRK11269 930171010093 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930171010094 PYR/PP interface [polypeptide binding]; other site 930171010095 dimer interface [polypeptide binding]; other site 930171010096 TPP binding site [chemical binding]; other site 930171010097 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930171010098 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 930171010099 TPP-binding site [chemical binding]; other site 930171010100 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 930171010101 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 930171010102 allantoinase; Region: allantoinase; TIGR03178 930171010103 active site 930171010104 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930171010105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930171010106 DNA binding site [nucleotide binding] 930171010107 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 930171010108 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 930171010109 catalytic triad [active] 930171010110 H+ Antiporter protein; Region: 2A0121; TIGR00900 930171010111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010112 putative substrate translocation pore; other site 930171010113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171010114 Coenzyme A binding pocket [chemical binding]; other site 930171010115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171010116 Response regulator receiver domain; Region: Response_reg; pfam00072 930171010117 active site 930171010118 phosphorylation site [posttranslational modification] 930171010119 intermolecular recognition site; other site 930171010120 dimerization interface [polypeptide binding]; other site 930171010121 putative OHCU decarboxylase; Provisional; Region: PRK13798 930171010122 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 930171010123 active site 930171010124 homotetramer interface [polypeptide binding]; other site 930171010125 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 930171010126 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 930171010127 active site 930171010128 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930171010129 active site 930171010130 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 930171010131 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 930171010132 dimerization interface [polypeptide binding]; other site 930171010133 putative ATP binding site [chemical binding]; other site 930171010134 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 930171010135 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171010136 Walker A/P-loop; other site 930171010137 ATP binding site [chemical binding]; other site 930171010138 Q-loop/lid; other site 930171010139 ABC transporter signature motif; other site 930171010140 Walker B; other site 930171010141 D-loop; other site 930171010142 H-loop/switch region; other site 930171010143 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171010144 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 930171010145 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171010146 Walker A/P-loop; other site 930171010147 ATP binding site [chemical binding]; other site 930171010148 Q-loop/lid; other site 930171010149 ABC transporter signature motif; other site 930171010150 Walker B; other site 930171010151 D-loop; other site 930171010152 H-loop/switch region; other site 930171010153 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171010154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010155 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171010156 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 930171010157 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 930171010158 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930171010159 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930171010160 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 930171010161 Septum formation; Region: Septum_form; pfam13845 930171010162 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 930171010163 Clp amino terminal domain; Region: Clp_N; pfam02861 930171010164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171010165 Walker A motif; other site 930171010166 ATP binding site [chemical binding]; other site 930171010167 Walker B motif; other site 930171010168 arginine finger; other site 930171010169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171010170 Walker A motif; other site 930171010171 ATP binding site [chemical binding]; other site 930171010172 Walker B motif; other site 930171010173 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 930171010174 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 930171010175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171010176 Walker A/P-loop; other site 930171010177 ATP binding site [chemical binding]; other site 930171010178 Q-loop/lid; other site 930171010179 ABC transporter signature motif; other site 930171010180 Walker B; other site 930171010181 D-loop; other site 930171010182 H-loop/switch region; other site 930171010183 TOBE domain; Region: TOBE; pfam03459 930171010184 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 930171010185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171010186 putative PBP binding loops; other site 930171010187 ABC-ATPase subunit interface; other site 930171010188 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 930171010189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 930171010190 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 930171010191 DNA binding residues [nucleotide binding] 930171010192 TOBE domain; Region: TOBE; cl01440 930171010193 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 930171010194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 930171010195 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 930171010196 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 930171010197 hypothetical protein; Provisional; Region: PRK11770 930171010198 Domain of unknown function (DUF307); Region: DUF307; pfam03733 930171010199 Domain of unknown function (DUF307); Region: DUF307; pfam03733 930171010200 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 930171010201 active site 930171010202 HutD; Region: HutD; pfam05962 930171010203 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171010204 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171010205 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171010206 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 930171010207 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 930171010208 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 930171010209 Walker A/P-loop; other site 930171010210 ATP binding site [chemical binding]; other site 930171010211 Q-loop/lid; other site 930171010212 ABC transporter signature motif; other site 930171010213 Walker B; other site 930171010214 D-loop; other site 930171010215 H-loop/switch region; other site 930171010216 TOBE domain; Region: TOBE_2; pfam08402 930171010217 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171010218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171010219 dimer interface [polypeptide binding]; other site 930171010220 conserved gate region; other site 930171010221 putative PBP binding loops; other site 930171010222 ABC-ATPase subunit interface; other site 930171010223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171010224 dimer interface [polypeptide binding]; other site 930171010225 conserved gate region; other site 930171010226 putative PBP binding loops; other site 930171010227 ABC-ATPase subunit interface; other site 930171010228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171010229 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 930171010230 D-allose kinase; Provisional; Region: PRK09698 930171010231 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930171010232 nucleotide binding site [chemical binding]; other site 930171010233 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 930171010234 Ferritin-like domain; Region: Ferritin; pfam00210 930171010235 ferroxidase diiron center [ion binding]; other site 930171010236 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930171010237 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930171010238 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171010239 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171010240 DNA binding site [nucleotide binding] 930171010241 domain linker motif; other site 930171010242 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 930171010243 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 930171010244 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 930171010245 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 930171010246 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 930171010247 Ca binding site [ion binding]; other site 930171010248 active site 930171010249 catalytic site [active] 930171010250 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 930171010251 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 930171010252 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 930171010253 active site 930171010254 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171010255 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171010256 active site 930171010257 catalytic tetrad [active] 930171010258 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 930171010259 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 930171010260 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930171010261 ATP binding site [chemical binding]; other site 930171010262 putative Mg++ binding site [ion binding]; other site 930171010263 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171010264 nucleotide binding region [chemical binding]; other site 930171010265 ATP-binding site [chemical binding]; other site 930171010266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930171010267 S-adenosylmethionine binding site [chemical binding]; other site 930171010268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010269 putative substrate translocation pore; other site 930171010270 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 930171010271 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 930171010272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010273 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 930171010274 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 930171010275 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 930171010276 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 930171010277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930171010278 DNA binding residues [nucleotide binding] 930171010279 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171010280 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171010281 DNA binding site [nucleotide binding] 930171010282 domain linker motif; other site 930171010283 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171010284 dimerization interface [polypeptide binding]; other site 930171010285 ligand binding site [chemical binding]; other site 930171010286 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930171010287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930171010288 substrate binding pocket [chemical binding]; other site 930171010289 membrane-bound complex binding site; other site 930171010290 hinge residues; other site 930171010291 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930171010292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171010293 dimer interface [polypeptide binding]; other site 930171010294 conserved gate region; other site 930171010295 putative PBP binding loops; other site 930171010296 ABC-ATPase subunit interface; other site 930171010297 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930171010298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171010299 Walker A/P-loop; other site 930171010300 ATP binding site [chemical binding]; other site 930171010301 Q-loop/lid; other site 930171010302 ABC transporter signature motif; other site 930171010303 Walker B; other site 930171010304 D-loop; other site 930171010305 H-loop/switch region; other site 930171010306 putative oxidoreductase; Provisional; Region: PRK11579 930171010307 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171010308 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171010309 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930171010310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171010311 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 930171010312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930171010313 ATP binding site [chemical binding]; other site 930171010314 putative Mg++ binding site [ion binding]; other site 930171010315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930171010316 nucleotide binding region [chemical binding]; other site 930171010317 ATP-binding site [chemical binding]; other site 930171010318 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 930171010319 active site 930171010320 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 930171010321 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171010322 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171010323 DNA binding site [nucleotide binding] 930171010324 domain linker motif; other site 930171010325 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 930171010326 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 930171010327 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930171010328 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 930171010329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171010330 dimer interface [polypeptide binding]; other site 930171010331 conserved gate region; other site 930171010332 putative PBP binding loops; other site 930171010333 ABC-ATPase subunit interface; other site 930171010334 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171010335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171010336 putative PBP binding loops; other site 930171010337 dimer interface [polypeptide binding]; other site 930171010338 ABC-ATPase subunit interface; other site 930171010339 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171010340 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171010341 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171010342 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 930171010343 conserved cys residue [active] 930171010344 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 930171010345 putative active site [active] 930171010346 putative metal binding site [ion binding]; other site 930171010347 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 930171010348 glutamate dehydrogenase; Provisional; Region: PRK09414 930171010349 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 930171010350 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 930171010351 NAD(P) binding site [chemical binding]; other site 930171010352 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 930171010353 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 930171010354 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 930171010355 active site 930171010356 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 930171010357 trehalose synthase; Region: treS_nterm; TIGR02456 930171010358 active site 930171010359 catalytic site [active] 930171010360 prephenate dehydratase; Provisional; Region: PRK11899 930171010361 Prephenate dehydratase; Region: PDT; pfam00800 930171010362 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 930171010363 putative L-Phe binding site [chemical binding]; other site 930171010364 phenol 2-monooxygenase; Provisional; Region: PRK08294 930171010365 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 930171010366 dimer interface [polypeptide binding]; other site 930171010367 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 930171010368 putative homodimer interface [polypeptide binding]; other site 930171010369 putative homotetramer interface [polypeptide binding]; other site 930171010370 putative allosteric switch controlling residues; other site 930171010371 putative metal binding site [ion binding]; other site 930171010372 putative homodimer-homodimer interface [polypeptide binding]; other site 930171010373 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930171010374 active site residue [active] 930171010375 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930171010376 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930171010377 active site residue [active] 930171010378 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930171010379 active site residue [active] 930171010380 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930171010381 catalytic residues [active] 930171010382 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930171010383 active site residue [active] 930171010384 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 930171010385 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930171010386 active site residue [active] 930171010387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010388 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171010389 putative substrate translocation pore; other site 930171010390 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 930171010391 DNA binding residues [nucleotide binding] 930171010392 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930171010393 putative dimer interface [polypeptide binding]; other site 930171010394 chaperone protein DnaJ; Provisional; Region: PRK14279 930171010395 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 930171010396 HSP70 interaction site [polypeptide binding]; other site 930171010397 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 930171010398 dimer interface [polypeptide binding]; other site 930171010399 GrpE; Region: GrpE; pfam01025 930171010400 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 930171010401 dimer interface [polypeptide binding]; other site 930171010402 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 930171010403 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 930171010404 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930171010405 nucleotide binding site [chemical binding]; other site 930171010406 MMPL family; Region: MMPL; pfam03176 930171010407 MMPL family; Region: MMPL; pfam03176 930171010408 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 930171010409 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930171010410 MarR family; Region: MarR_2; cl17246 930171010411 LysE type translocator; Region: LysE; cl00565 930171010412 Low molecular weight phosphatase family; Region: LMWPc; cl00105 930171010413 hypothetical protein; Provisional; Region: PRK06547 930171010414 AAA domain; Region: AAA_18; pfam13238 930171010415 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 930171010416 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 930171010417 chorismate binding enzyme; Region: Chorismate_bind; cl10555 930171010418 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930171010419 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 930171010420 NodB motif; other site 930171010421 active site 930171010422 catalytic site [active] 930171010423 metal binding site [ion binding]; metal-binding site 930171010424 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171010425 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171010426 DNA binding site [nucleotide binding] 930171010427 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 930171010428 putative dimerization interface [polypeptide binding]; other site 930171010429 putative ligand binding site [chemical binding]; other site 930171010430 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 930171010431 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 930171010432 active site 930171010433 catalytic residues [active] 930171010434 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171010435 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171010436 DNA binding site [nucleotide binding] 930171010437 domain linker motif; other site 930171010438 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 930171010439 putative dimerization interface [polypeptide binding]; other site 930171010440 putative ligand binding site [chemical binding]; other site 930171010441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171010442 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930171010443 putative PBP binding loops; other site 930171010444 dimer interface [polypeptide binding]; other site 930171010445 ABC-ATPase subunit interface; other site 930171010446 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 930171010447 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 930171010448 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 930171010449 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 930171010450 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 930171010451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010452 putative substrate translocation pore; other site 930171010453 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 930171010454 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 930171010455 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 930171010456 putative active site [active] 930171010457 catalytic site [active] 930171010458 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 930171010459 putative active site [active] 930171010460 catalytic site [active] 930171010461 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 930171010462 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 930171010463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171010464 catalytic residue [active] 930171010465 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 930171010466 tetracycline repressor protein TetR; Provisional; Region: PRK13756 930171010467 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171010468 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 930171010469 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 930171010470 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 930171010471 active site residue [active] 930171010472 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 930171010473 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930171010474 homodimer interface [polypeptide binding]; other site 930171010475 substrate-cofactor binding pocket; other site 930171010476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171010477 catalytic residue [active] 930171010478 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 930171010479 Domain of unknown function (DUF222); Region: DUF222; pfam02720 930171010480 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171010481 active site 930171010482 carboxylate-amine ligase; Provisional; Region: PRK13517 930171010483 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 930171010484 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930171010485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171010486 non-specific DNA binding site [nucleotide binding]; other site 930171010487 salt bridge; other site 930171010488 sequence-specific DNA binding site [nucleotide binding]; other site 930171010489 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 930171010490 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 930171010491 putative active site [active] 930171010492 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 930171010493 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 930171010494 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930171010495 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930171010496 Walker A/P-loop; other site 930171010497 ATP binding site [chemical binding]; other site 930171010498 Q-loop/lid; other site 930171010499 ABC transporter signature motif; other site 930171010500 Walker B; other site 930171010501 D-loop; other site 930171010502 H-loop/switch region; other site 930171010503 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930171010504 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 930171010505 Walker A/P-loop; other site 930171010506 ATP binding site [chemical binding]; other site 930171010507 Q-loop/lid; other site 930171010508 ABC transporter signature motif; other site 930171010509 Walker B; other site 930171010510 D-loop; other site 930171010511 H-loop/switch region; other site 930171010512 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 930171010513 Domain of unknown function (DUF336); Region: DUF336; cl01249 930171010514 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 930171010515 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930171010516 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930171010517 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 930171010518 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 930171010519 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 930171010520 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 930171010521 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 930171010522 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 930171010523 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 930171010524 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 930171010525 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 930171010526 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 930171010527 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 930171010528 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 930171010529 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 930171010530 Methane oxygenase PmoA; Region: PmoA; pfam14100 930171010531 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 930171010532 TrkA-C domain; Region: TrkA_C; pfam02080 930171010533 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 930171010534 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 930171010535 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 930171010536 trimer interface [polypeptide binding]; other site 930171010537 active site 930171010538 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 930171010539 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 930171010540 hydrophobic ligand binding site; other site 930171010541 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 930171010542 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 930171010543 putative active site [active] 930171010544 putative ligand binding site [chemical binding]; other site 930171010545 putative NAD(P) binding site [chemical binding]; other site 930171010546 H+ Antiporter protein; Region: 2A0121; TIGR00900 930171010547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010548 putative substrate translocation pore; other site 930171010549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171010551 putative Zn2+ binding site [ion binding]; other site 930171010552 putative DNA binding site [nucleotide binding]; other site 930171010553 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 930171010554 dimerization interface [polypeptide binding]; other site 930171010555 Proline dehydrogenase; Region: Pro_dh; cl03282 930171010556 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 930171010557 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930171010558 NAD(P) binding site [chemical binding]; other site 930171010559 catalytic residues [active] 930171010560 amino acid transporter; Region: 2A0306; TIGR00909 930171010561 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 930171010562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930171010563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171010564 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 930171010565 putative dimerization interface [polypeptide binding]; other site 930171010566 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 930171010567 tetramerization interface [polypeptide binding]; other site 930171010568 active site 930171010569 Predicted permeases [General function prediction only]; Region: COG0679 930171010570 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 930171010571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010572 putative substrate translocation pore; other site 930171010573 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 930171010574 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 930171010575 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171010576 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171010577 active site 930171010578 catalytic tetrad [active] 930171010579 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 930171010580 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 930171010581 potential catalytic triad [active] 930171010582 conserved cys residue [active] 930171010583 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 930171010584 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 930171010585 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 930171010586 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930171010587 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 930171010588 NHL repeat; Region: NHL; pfam01436 930171010589 NHL repeat; Region: NHL; pfam01436 930171010590 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 930171010591 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 930171010592 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 930171010593 IHF dimer interface [polypeptide binding]; other site 930171010594 IHF - DNA interface [nucleotide binding]; other site 930171010595 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 930171010596 Helix-turn-helix domain; Region: HTH_38; pfam13936 930171010597 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171010598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171010599 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171010600 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 930171010601 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930171010602 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 930171010603 Transposase, Mutator family; Region: Transposase_mut; pfam00872 930171010604 MULE transposase domain; Region: MULE; pfam10551 930171010605 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 930171010606 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 930171010607 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 930171010608 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 930171010609 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 930171010610 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930171010611 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930171010612 DNA binding site [nucleotide binding] 930171010613 domain linker motif; other site 930171010614 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930171010615 ligand binding site [chemical binding]; other site 930171010616 dimerization interface [polypeptide binding]; other site 930171010617 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 930171010618 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 930171010619 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 930171010620 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 930171010621 active site 930171010622 catalytic triad [active] 930171010623 oxyanion hole [active] 930171010624 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930171010625 MarR family; Region: MarR_2; cl17246 930171010626 MarR family; Region: MarR_2; cl17246 930171010627 YCII-related domain; Region: YCII; cl00999 930171010628 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 930171010629 active site 930171010630 catalytic triad [active] 930171010631 oxyanion hole [active] 930171010632 Helix-turn-helix domain; Region: HTH_28; pfam13518 930171010633 putative transposase OrfB; Reviewed; Region: PHA02517 930171010634 HTH-like domain; Region: HTH_21; pfam13276 930171010635 Integrase core domain; Region: rve; pfam00665 930171010636 Integrase core domain; Region: rve_2; pfam13333 930171010637 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 930171010638 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 930171010639 FAD binding pocket [chemical binding]; other site 930171010640 FAD binding motif [chemical binding]; other site 930171010641 phosphate binding motif [ion binding]; other site 930171010642 NAD binding pocket [chemical binding]; other site 930171010643 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930171010644 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930171010645 Walker A/P-loop; other site 930171010646 ATP binding site [chemical binding]; other site 930171010647 Q-loop/lid; other site 930171010648 ABC transporter signature motif; other site 930171010649 Walker B; other site 930171010650 D-loop; other site 930171010651 H-loop/switch region; other site 930171010652 FecCD transport family; Region: FecCD; pfam01032 930171010653 ABC-ATPase subunit interface; other site 930171010654 dimer interface [polypeptide binding]; other site 930171010655 putative PBP binding regions; other site 930171010656 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930171010657 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930171010658 ABC-ATPase subunit interface; other site 930171010659 dimer interface [polypeptide binding]; other site 930171010660 putative PBP binding regions; other site 930171010661 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 930171010662 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 930171010663 siderophore binding site; other site 930171010664 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 930171010665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 930171010666 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 930171010667 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 930171010668 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 930171010669 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 930171010670 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 930171010671 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 930171010672 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 930171010673 active site 930171010674 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 930171010675 hypothetical protein; Provisional; Region: PRK04233 930171010676 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171010677 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171010678 active site 930171010679 catalytic tetrad [active] 930171010680 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 930171010681 NmrA-like family; Region: NmrA; pfam05368 930171010682 NADP binding site [chemical binding]; other site 930171010683 sulfite oxidase; Provisional; Region: PLN00177 930171010684 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 930171010685 Moco binding site; other site 930171010686 metal coordination site [ion binding]; other site 930171010687 dimerization interface [polypeptide binding]; other site 930171010688 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930171010689 RNA binding surface [nucleotide binding]; other site 930171010690 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930171010691 Amidohydrolase family; Region: Amidohydro_3; pfam07969 930171010692 active site 930171010693 Domain of unknown function (DUF222); Region: DUF222; pfam02720 930171010694 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 930171010695 active site 930171010696 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 930171010697 putative uracil binding site [chemical binding]; other site 930171010698 putative active site [active] 930171010699 HipA N-terminal domain; Region: Couple_hipA; pfam13657 930171010700 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 930171010701 HipA-like N-terminal domain; Region: HipA_N; pfam07805 930171010702 HipA-like C-terminal domain; Region: HipA_C; pfam07804 930171010703 transcriptional regulator, y4mF family; Region: couple_hipB; TIGR03070 930171010704 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 930171010705 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 930171010706 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930171010707 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171010708 DNA-binding site [nucleotide binding]; DNA binding site 930171010709 FCD domain; Region: FCD; pfam07729 930171010710 L-asparaginase II; Region: Asparaginase_II; pfam06089 930171010711 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 930171010712 Aspartase; Region: Aspartase; cd01357 930171010713 active sites [active] 930171010714 tetramer interface [polypeptide binding]; other site 930171010715 L-asparagine permease; Provisional; Region: PRK15049 930171010716 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 930171010717 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 930171010718 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 930171010719 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 930171010720 NAD binding site [chemical binding]; other site 930171010721 dimer interface [polypeptide binding]; other site 930171010722 substrate binding site [chemical binding]; other site 930171010723 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930171010724 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 930171010725 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 930171010726 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930171010727 substrate binding pocket [chemical binding]; other site 930171010728 catalytic triad [active] 930171010729 HD domain; Region: HD_4; pfam13328 930171010730 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 930171010731 active site 930171010732 HIGH motif; other site 930171010733 nucleotide binding site [chemical binding]; other site 930171010734 active site 930171010735 KMSKS motif; other site 930171010736 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930171010737 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 930171010738 AsnC family; Region: AsnC_trans_reg; pfam01037 930171010739 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 930171010740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171010741 putative DNA binding site [nucleotide binding]; other site 930171010742 putative Zn2+ binding site [ion binding]; other site 930171010743 AsnC family; Region: AsnC_trans_reg; pfam01037 930171010744 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 930171010745 SnoaL-like domain; Region: SnoaL_2; pfam12680 930171010746 Protein of unknown function (DUF456); Region: DUF456; pfam04306 930171010747 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 930171010748 Malic enzyme, N-terminal domain; Region: malic; pfam00390 930171010749 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 930171010750 NAD(P) binding pocket [chemical binding]; other site 930171010751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171010752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171010753 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171010754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010755 putative substrate translocation pore; other site 930171010756 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 930171010757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171010759 putative substrate translocation pore; other site 930171010760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010761 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 930171010762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010763 putative substrate translocation pore; other site 930171010764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010765 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930171010766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171010767 Coenzyme A binding pocket [chemical binding]; other site 930171010768 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 930171010769 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 930171010770 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 930171010771 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 930171010772 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 930171010773 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 930171010774 active site 930171010775 P-loop; other site 930171010776 phosphorylation site [posttranslational modification] 930171010777 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930171010778 active site 930171010779 phosphorylation site [posttranslational modification] 930171010780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171010781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171010782 WHG domain; Region: WHG; pfam13305 930171010783 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 930171010784 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 930171010785 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930171010786 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 930171010787 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930171010788 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930171010789 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 930171010790 catalytic site [active] 930171010791 Helix-turn-helix domain; Region: HTH_17; pfam12728 930171010792 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930171010793 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 930171010794 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 930171010795 hexamer interface [polypeptide binding]; other site 930171010796 ligand binding site [chemical binding]; other site 930171010797 putative active site [active] 930171010798 NAD(P) binding site [chemical binding]; other site 930171010799 putative oxidoreductase; Provisional; Region: PRK11579 930171010800 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171010801 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930171010802 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 930171010803 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 930171010804 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 930171010805 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171010806 Walker A/P-loop; other site 930171010807 ATP binding site [chemical binding]; other site 930171010808 Q-loop/lid; other site 930171010809 ABC transporter signature motif; other site 930171010810 Walker B; other site 930171010811 D-loop; other site 930171010812 H-loop/switch region; other site 930171010813 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171010814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930171010815 Walker A/P-loop; other site 930171010816 ATP binding site [chemical binding]; other site 930171010817 Q-loop/lid; other site 930171010818 ABC transporter signature motif; other site 930171010819 Walker B; other site 930171010820 D-loop; other site 930171010821 H-loop/switch region; other site 930171010822 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930171010823 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930171010824 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 930171010825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171010826 dimer interface [polypeptide binding]; other site 930171010827 conserved gate region; other site 930171010828 putative PBP binding loops; other site 930171010829 ABC-ATPase subunit interface; other site 930171010830 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930171010831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171010832 dimer interface [polypeptide binding]; other site 930171010833 conserved gate region; other site 930171010834 putative PBP binding loops; other site 930171010835 ABC-ATPase subunit interface; other site 930171010836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171010837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171010838 Predicted flavoprotein [General function prediction only]; Region: COG0431 930171010839 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930171010840 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 930171010841 nucleotide binding site [chemical binding]; other site 930171010842 Sporulation and spore germination; Region: Germane; pfam10646 930171010843 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930171010844 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171010845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171010846 homodimer interface [polypeptide binding]; other site 930171010847 catalytic residue [active] 930171010848 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171010849 Ligand Binding Site [chemical binding]; other site 930171010850 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 930171010851 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930171010852 E3 interaction surface; other site 930171010853 lipoyl attachment site [posttranslational modification]; other site 930171010854 e3 binding domain; Region: E3_binding; pfam02817 930171010855 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930171010856 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 930171010857 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 930171010858 alpha subunit interface [polypeptide binding]; other site 930171010859 TPP binding site [chemical binding]; other site 930171010860 heterodimer interface [polypeptide binding]; other site 930171010861 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930171010862 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 930171010863 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 930171010864 tetramer interface [polypeptide binding]; other site 930171010865 TPP-binding site [chemical binding]; other site 930171010866 heterodimer interface [polypeptide binding]; other site 930171010867 phosphorylation loop region [posttranslational modification] 930171010868 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 930171010869 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171010870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171010871 homodimer interface [polypeptide binding]; other site 930171010872 catalytic residue [active] 930171010873 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 930171010874 active site 930171010875 catalytic triad [active] 930171010876 putative pectinesterase; Region: PLN02432; cl01911 930171010877 Pectinesterase; Region: Pectinesterase; pfam01095 930171010878 Amb_all domain; Region: Amb_all; smart00656 930171010879 Membrane protein of unknown function; Region: DUF360; pfam04020 930171010880 adenylosuccinate lyase; Provisional; Region: PRK09285 930171010881 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 930171010882 tetramer interface [polypeptide binding]; other site 930171010883 active site 930171010884 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930171010885 catalytic core [active] 930171010886 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930171010887 Catalytic domain of Protein Kinases; Region: PKc; cd00180 930171010888 active site 930171010889 ATP binding site [chemical binding]; other site 930171010890 substrate binding site [chemical binding]; other site 930171010891 activation loop (A-loop); other site 930171010892 MarR family; Region: MarR; pfam01047 930171010893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930171010894 Coenzyme A binding pocket [chemical binding]; other site 930171010895 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 930171010896 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 930171010897 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 930171010898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171010899 Walker A/P-loop; other site 930171010900 ATP binding site [chemical binding]; other site 930171010901 Q-loop/lid; other site 930171010902 ABC transporter signature motif; other site 930171010903 Walker B; other site 930171010904 D-loop; other site 930171010905 H-loop/switch region; other site 930171010906 TOBE domain; Region: TOBE_2; pfam08402 930171010907 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 930171010908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171010909 dimer interface [polypeptide binding]; other site 930171010910 conserved gate region; other site 930171010911 putative PBP binding loops; other site 930171010912 ABC-ATPase subunit interface; other site 930171010913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171010914 dimer interface [polypeptide binding]; other site 930171010915 conserved gate region; other site 930171010916 putative PBP binding loops; other site 930171010917 ABC-ATPase subunit interface; other site 930171010918 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 930171010919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 930171010920 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 930171010921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171010922 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 930171010923 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171010924 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 930171010925 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171010926 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 930171010927 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 930171010928 lipid kinase; Reviewed; Region: PRK13054 930171010929 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 930171010930 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 930171010931 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 930171010932 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 930171010933 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 930171010934 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 930171010935 ligand binding site [chemical binding]; other site 930171010936 homodimer interface [polypeptide binding]; other site 930171010937 NAD(P) binding site [chemical binding]; other site 930171010938 trimer interface B [polypeptide binding]; other site 930171010939 trimer interface A [polypeptide binding]; other site 930171010940 Protein of unknown function (DUF419); Region: DUF419; pfam04237 930171010941 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 930171010942 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 930171010943 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171010944 Coenzyme A transferase; Region: CoA_trans; cl17247 930171010945 Coenzyme A transferase; Region: CoA_trans; cl17247 930171010946 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 930171010947 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930171010948 dimer interface [polypeptide binding]; other site 930171010949 active site 930171010950 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 930171010951 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 930171010952 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 930171010953 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 930171010954 tetramer interface [polypeptide binding]; other site 930171010955 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 930171010956 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 930171010957 active site 930171010958 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 930171010959 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 930171010960 active site 930171010961 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930171010962 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 930171010963 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 930171010964 active site 930171010965 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 930171010966 active site 930171010967 metal binding site [ion binding]; metal-binding site 930171010968 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 930171010969 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 930171010970 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 930171010971 shikimate binding site; other site 930171010972 NAD(P) binding site [chemical binding]; other site 930171010973 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171010974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171010975 putative DNA binding site [nucleotide binding]; other site 930171010976 putative Zn2+ binding site [ion binding]; other site 930171010977 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171010978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171010979 metabolite-proton symporter; Region: 2A0106; TIGR00883 930171010980 putative substrate translocation pore; other site 930171010981 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 930171010982 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 930171010983 active site 930171010984 DNA binding site [nucleotide binding] 930171010985 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 930171010986 DNA binding site [nucleotide binding] 930171010987 Membrane transport protein; Region: Mem_trans; cl09117 930171010988 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 930171010989 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 930171010990 trehalose synthase; Region: treS_nterm; TIGR02456 930171010991 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 930171010992 active site 930171010993 catalytic site [active] 930171010994 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 930171010995 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 930171010996 hydrophobic ligand binding site; other site 930171010997 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 930171010998 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 930171010999 active site 930171011000 non-prolyl cis peptide bond; other site 930171011001 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 930171011002 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 930171011003 active site 930171011004 iron coordination sites [ion binding]; other site 930171011005 substrate binding pocket [chemical binding]; other site 930171011006 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930171011007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171011008 dimer interface [polypeptide binding]; other site 930171011009 conserved gate region; other site 930171011010 putative PBP binding loops; other site 930171011011 ABC-ATPase subunit interface; other site 930171011012 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 930171011013 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 930171011014 Walker A/P-loop; other site 930171011015 ATP binding site [chemical binding]; other site 930171011016 Q-loop/lid; other site 930171011017 ABC transporter signature motif; other site 930171011018 Walker B; other site 930171011019 D-loop; other site 930171011020 H-loop/switch region; other site 930171011021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930171011022 NMT1/THI5 like; Region: NMT1; pfam09084 930171011023 substrate binding pocket [chemical binding]; other site 930171011024 membrane-bound complex binding site; other site 930171011025 hinge residues; other site 930171011026 aminotransferase AlaT; Validated; Region: PRK09265 930171011027 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930171011028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171011029 homodimer interface [polypeptide binding]; other site 930171011030 catalytic residue [active] 930171011031 Ubiquitin-like proteins; Region: UBQ; cl00155 930171011032 charged pocket; other site 930171011033 hydrophobic patch; other site 930171011034 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 930171011035 active site 930171011036 catalytic site [active] 930171011037 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930171011038 Ligand Binding Site [chemical binding]; other site 930171011039 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 930171011040 putative homodimer interface [polypeptide binding]; other site 930171011041 putative homotetramer interface [polypeptide binding]; other site 930171011042 putative allosteric switch controlling residues; other site 930171011043 putative metal binding site [ion binding]; other site 930171011044 putative homodimer-homodimer interface [polypeptide binding]; other site 930171011045 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 930171011046 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 930171011047 metal-binding site [ion binding] 930171011048 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 930171011049 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930171011050 Soluble P-type ATPase [General function prediction only]; Region: COG4087 930171011051 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 930171011052 EamA-like transporter family; Region: EamA; pfam00892 930171011053 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 930171011054 CGNR zinc finger; Region: zf-CGNR; pfam11706 930171011055 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 930171011056 putative efflux protein, MATE family; Region: matE; TIGR00797 930171011057 DoxX; Region: DoxX; pfam07681 930171011058 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 930171011059 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 930171011060 replicative DNA helicase; Region: DnaB; TIGR00665 930171011061 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 930171011062 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 930171011063 Walker A motif; other site 930171011064 ATP binding site [chemical binding]; other site 930171011065 Walker B motif; other site 930171011066 DNA binding loops [nucleotide binding] 930171011067 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 930171011068 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930171011069 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 930171011070 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 930171011071 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 930171011072 Uncharacterized conserved protein [Function unknown]; Region: COG1434 930171011073 putative active site [active] 930171011074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 930171011075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 930171011076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 930171011077 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 930171011078 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930171011079 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930171011080 dimer interface [polypeptide binding]; other site 930171011081 ssDNA binding site [nucleotide binding]; other site 930171011082 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930171011083 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 930171011084 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 930171011085 Spore germination protein; Region: Spore_permease; cl17796 930171011086 AAA ATPase domain; Region: AAA_16; pfam13191 930171011087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171011088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171011089 DNA binding residues [nucleotide binding] 930171011090 dimerization interface [polypeptide binding]; other site 930171011091 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 930171011092 Bacterial sugar transferase; Region: Bac_transf; pfam02397 930171011093 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171011094 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171011095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171011096 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930171011097 NAD(P) binding site [chemical binding]; other site 930171011098 active site 930171011099 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 930171011100 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 930171011101 inhibitor-cofactor binding pocket; inhibition site 930171011102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171011103 catalytic residue [active] 930171011104 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 930171011105 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 930171011106 putative trimer interface [polypeptide binding]; other site 930171011107 putative CoA binding site [chemical binding]; other site 930171011108 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 930171011109 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 930171011110 inhibitor-cofactor binding pocket; inhibition site 930171011111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930171011112 catalytic residue [active] 930171011113 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 930171011114 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 930171011115 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930171011116 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930171011117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930171011118 active site 930171011119 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 930171011120 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930171011121 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 930171011122 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 930171011123 putative ADP-binding pocket [chemical binding]; other site 930171011124 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930171011125 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 930171011126 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 930171011127 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 930171011128 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 930171011129 Probable Catalytic site; other site 930171011130 metal-binding site 930171011131 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930171011132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 930171011133 active site 930171011134 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 930171011135 Bacterial Ig-like domain; Region: Big_5; pfam13205 930171011136 Bacterial Ig-like domain; Region: Big_5; pfam13205 930171011137 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 930171011138 Bacterial Ig-like domain; Region: Big_5; pfam13205 930171011139 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 930171011140 Bacterial Ig-like domain; Region: Big_5; pfam13205 930171011141 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 930171011142 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 930171011143 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 930171011144 active site 930171011145 metal binding site [ion binding]; metal-binding site 930171011146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930171011147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930171011148 active site 930171011149 phosphorylation site [posttranslational modification] 930171011150 intermolecular recognition site; other site 930171011151 dimerization interface [polypeptide binding]; other site 930171011152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930171011153 DNA binding residues [nucleotide binding] 930171011154 dimerization interface [polypeptide binding]; other site 930171011155 Competence protein; Region: Competence; cl00471 930171011156 Histidine kinase; Region: HisKA_3; pfam07730 930171011157 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 930171011158 Mg2+ binding site [ion binding]; other site 930171011159 G-X-G motif; other site 930171011160 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930171011161 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930171011162 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 930171011163 Walker A/P-loop; other site 930171011164 ATP binding site [chemical binding]; other site 930171011165 Q-loop/lid; other site 930171011166 ABC transporter signature motif; other site 930171011167 Walker B; other site 930171011168 D-loop; other site 930171011169 H-loop/switch region; other site 930171011170 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 930171011171 active site 930171011172 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 930171011173 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930171011174 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930171011175 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930171011176 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930171011177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171011178 Walker A/P-loop; other site 930171011179 ATP binding site [chemical binding]; other site 930171011180 Q-loop/lid; other site 930171011181 ABC transporter signature motif; other site 930171011182 Walker B; other site 930171011183 D-loop; other site 930171011184 H-loop/switch region; other site 930171011185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930171011186 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 930171011187 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 930171011188 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930171011189 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 930171011190 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 930171011191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930171011192 Predicted integral membrane protein [Function unknown]; Region: COG5650 930171011193 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930171011194 catalytic core [active] 930171011195 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 930171011196 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 930171011197 active site 930171011198 NTP binding site [chemical binding]; other site 930171011199 metal binding triad [ion binding]; metal-binding site 930171011200 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 930171011201 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930171011202 Zn2+ binding site [ion binding]; other site 930171011203 Mg2+ binding site [ion binding]; other site 930171011204 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 930171011205 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 930171011206 active site 930171011207 Ap6A binding site [chemical binding]; other site 930171011208 nudix motif; other site 930171011209 metal binding site [ion binding]; metal-binding site 930171011210 integral membrane protein MviN; Region: mviN; TIGR01695 930171011211 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 930171011212 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 930171011213 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930171011214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171011215 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930171011216 catalytic residues [active] 930171011217 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 930171011218 ParB-like nuclease domain; Region: ParBc; pfam02195 930171011219 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 930171011220 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930171011221 Magnesium ion binding site [ion binding]; other site 930171011222 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 930171011223 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 930171011224 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 930171011225 G-X-X-G motif; other site 930171011226 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 930171011227 RxxxH motif; other site 930171011228 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 930171011229 Haemolytic domain; Region: Haemolytic; pfam01809 930171011230 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 930171011231 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 930171011232 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930171011233 MarR family; Region: MarR_2; pfam12802 930171011234 MarR family; Region: MarR_2; cl17246 930171011235 Predicted membrane protein [Function unknown]; Region: COG2259 930171011236 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 930171011237 adenylate kinase; Reviewed; Region: adk; PRK00279 930171011238 AMP-binding site [chemical binding]; other site 930171011239 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 930171011240 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 930171011241 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 930171011242 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 930171011243 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930171011244 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 930171011245 Cupin domain; Region: Cupin_2; pfam07883 930171011246 Cupin domain; Region: Cupin_2; cl17218 930171011247 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 930171011248 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 930171011249 acyl-activating enzyme (AAE) consensus motif; other site 930171011250 active site 930171011251 AMP binding site [chemical binding]; other site 930171011252 substrate binding site [chemical binding]; other site 930171011253 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 930171011254 CoA binding domain; Region: CoA_binding_2; pfam13380 930171011255 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 930171011256 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 930171011257 FAD binding domain; Region: FAD_binding_3; pfam01494 930171011258 hypothetical protein; Provisional; Region: PRK07236 930171011259 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171011260 putative DNA binding site [nucleotide binding]; other site 930171011261 putative Zn2+ binding site [ion binding]; other site 930171011262 dimerization interface [polypeptide binding]; other site 930171011263 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 930171011264 benzoate transport; Region: 2A0115; TIGR00895 930171011265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171011266 putative substrate translocation pore; other site 930171011267 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930171011268 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 930171011269 NAD(P) binding site [chemical binding]; other site 930171011270 catalytic residues [active] 930171011271 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 930171011272 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 930171011273 catalytic Zn binding site [ion binding]; other site 930171011274 NAD binding site [chemical binding]; other site 930171011275 structural Zn binding site [ion binding]; other site 930171011276 Integrase core domain; Region: rve_2; pfam13333 930171011277 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171011278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171011279 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171011280 HTH-like domain; Region: HTH_21; pfam13276 930171011281 Integrase core domain; Region: rve; pfam00665 930171011282 potential frameshift: common BLAST hit: gi|116662217|ref|YP_829272.1| transposase, mutator type 930171011283 MULE transposase domain; Region: MULE; pfam10551 930171011284 replication factor C small subunit; Reviewed; Region: rfc; PRK00440 930171011285 Transposase, Mutator family; Region: Transposase_mut; pfam00872 930171011286 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930171011287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 930171011288 DNA-binding site [nucleotide binding]; DNA binding site 930171011289 FCD domain; Region: FCD; pfam07729 930171011290 Integrase core domain; Region: rve; pfam00665 930171011291 Integrase core domain; Region: rve_3; pfam13683 930171011292 putative transposase OrfB; Reviewed; Region: PHA02517 930171011293 HTH-like domain; Region: HTH_21; pfam13276 930171011294 Integrase core domain; Region: rve; pfam00665 930171011295 Integrase core domain; Region: rve_3; pfam13683 930171011296 Transposase; Region: HTH_Tnp_1; pfam01527 930171011297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930171011298 Integrase core domain; Region: rve; pfam00665 930171011299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 930171011300 Integrase core domain; Region: rve_3; pfam13683 930171011301 SCP-2 sterol transfer family; Region: SCP2; pfam02036 930171011302 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 930171011303 alpha subunit interaction site [polypeptide binding]; other site 930171011304 beta subunit interaction site [polypeptide binding]; other site 930171011305 iron-sulfur cluster [ion binding]; other site 930171011306 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 930171011307 beta subunit interface [polypeptide binding]; other site 930171011308 alpha subunit interface [polypeptide binding]; other site 930171011309 active site 930171011310 substrate binding site [chemical binding]; other site 930171011311 Fe binding site [ion binding]; other site 930171011312 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 930171011313 inter-subunit interface; other site 930171011314 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 930171011315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930171011316 NAD(P) binding site [chemical binding]; other site 930171011317 active site 930171011318 Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952 930171011319 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 930171011320 putative active site [active] 930171011321 catalytic residue [active] 930171011322 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930171011323 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 930171011324 NAD(P) binding site [chemical binding]; other site 930171011325 catalytic residues [active] 930171011326 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 930171011327 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 930171011328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930171011329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930171011330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171011331 putative substrate translocation pore; other site 930171011332 putative transposase OrfB; Reviewed; Region: PHA02517 930171011333 HTH-like domain; Region: HTH_21; pfam13276 930171011334 Integrase core domain; Region: rve; pfam00665 930171011335 Integrase core domain; Region: rve_3; pfam13683 930171011336 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171011337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171011338 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171011339 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930171011340 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 930171011341 NAD(P) binding site [chemical binding]; other site 930171011342 catalytic residues [active] 930171011343 Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952 930171011344 putative active site [active] 930171011345 catalytic residue [active] 930171011346 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 930171011347 Cupin domain; Region: Cupin_2; pfam07883 930171011348 Cupin domain; Region: Cupin_2; pfam07883 930171011349 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 930171011350 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930171011351 AMP-binding enzyme; Region: AMP-binding; pfam00501 930171011352 acyl-activating enzyme (AAE) consensus motif; other site 930171011353 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930171011354 active site 930171011355 CoA binding site [chemical binding]; other site 930171011356 AMP binding site [chemical binding]; other site 930171011357 Predicted membrane protein [Function unknown]; Region: COG2259 930171011358 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 930171011359 multiple promoter invertase; Provisional; Region: mpi; PRK13413 930171011360 catalytic residues [active] 930171011361 catalytic nucleophile [active] 930171011362 Presynaptic Site I dimer interface [polypeptide binding]; other site 930171011363 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 930171011364 Synaptic Flat tetramer interface [polypeptide binding]; other site 930171011365 Synaptic Site I dimer interface [polypeptide binding]; other site 930171011366 DNA binding site [nucleotide binding] 930171011367 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 930171011368 DNA-binding interface [nucleotide binding]; DNA binding site 930171011369 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 930171011370 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 930171011371 dimer interface [polypeptide binding]; other site 930171011372 active site 930171011373 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 930171011374 active site 930171011375 dimer interface [polypeptide binding]; other site 930171011376 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 930171011377 metal binding site [ion binding]; metal-binding site 930171011378 Transposase; Region: HTH_Tnp_1; pfam01527 930171011379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930171011380 HTH-like domain; Region: HTH_21; pfam13276 930171011381 Integrase core domain; Region: rve; pfam00665 930171011382 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 930171011383 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 930171011384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 930171011385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171011386 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 930171011387 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 930171011388 active site 930171011389 metal binding site [ion binding]; metal-binding site 930171011390 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 930171011391 active site 930171011392 metal binding site [ion binding]; metal-binding site 930171011393 Cupin domain; Region: Cupin_2; pfam07883 930171011394 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 930171011395 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 930171011396 Transposase, Mutator family; Region: Transposase_mut; pfam00872 930171011397 MULE transposase domain; Region: MULE; pfam10551 930171011398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 930171011399 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930171011400 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 930171011401 NMT1/THI5 like; Region: NMT1; pfam09084 930171011402 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930171011403 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 930171011404 membrane-bound complex binding site; other site 930171011405 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 930171011406 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 930171011407 Walker A/P-loop; other site 930171011408 ATP binding site [chemical binding]; other site 930171011409 Q-loop/lid; other site 930171011410 ABC transporter signature motif; other site 930171011411 Walker B; other site 930171011412 D-loop; other site 930171011413 H-loop/switch region; other site 930171011414 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930171011415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171011416 dimer interface [polypeptide binding]; other site 930171011417 conserved gate region; other site 930171011418 putative PBP binding loops; other site 930171011419 ABC-ATPase subunit interface; other site 930171011420 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930171011421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171011422 dimer interface [polypeptide binding]; other site 930171011423 conserved gate region; other site 930171011424 ABC-ATPase subunit interface; other site 930171011425 Isochorismatase family; Region: Isochorismatase; pfam00857 930171011426 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 930171011427 catalytic triad [active] 930171011428 substrate binding site [chemical binding]; other site 930171011429 domain interfaces; other site 930171011430 conserved cis-peptide bond; other site 930171011431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171011432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171011433 putative substrate translocation pore; other site 930171011434 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171011435 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171011436 active site 930171011437 catalytic tetrad [active] 930171011438 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 930171011439 inter-subunit interface; other site 930171011440 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 930171011441 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 930171011442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171011443 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 930171011444 intersubunit interface [polypeptide binding]; other site 930171011445 active site 930171011446 Zn2+ binding site [ion binding]; other site 930171011447 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 930171011448 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171011449 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171011450 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 930171011451 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 930171011452 DNA binding residues [nucleotide binding] 930171011453 dimer interface [polypeptide binding]; other site 930171011454 metal binding site [ion binding]; metal-binding site 930171011455 mercuric reductase; Region: MerA; TIGR02053 930171011456 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171011457 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930171011458 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 930171011459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171011460 Walker A motif; other site 930171011461 ATP binding site [chemical binding]; other site 930171011462 Walker B motif; other site 930171011463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 930171011464 putative transposase OrfB; Reviewed; Region: PHA02517 930171011465 HTH-like domain; Region: HTH_21; pfam13276 930171011466 Integrase core domain; Region: rve; pfam00665 930171011467 Integrase core domain; Region: rve_3; pfam13683 930171011468 Transposase; Region: HTH_Tnp_1; pfam01527 930171011469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930171011470 Helix-turn-helix domain; Region: HTH_38; pfam13936 930171011471 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 930171011472 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171011473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171011474 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171011475 Transposase, Mutator family; Region: Transposase_mut; pfam00872 930171011476 MULE transposase domain; Region: MULE; pfam10551 930171011477 Transposase; Region: HTH_Tnp_1; pfam01527 930171011478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930171011479 HTH-like domain; Region: HTH_21; pfam13276 930171011480 Integrase core domain; Region: rve; pfam00665 930171011481 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 930171011482 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 930171011483 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 930171011484 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 930171011485 active site 930171011486 catalytic residues [active] 930171011487 DNA binding site [nucleotide binding] 930171011488 Int/Topo IB signature motif; other site 930171011489 META domain; Region: META; pfam03724 930171011490 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930171011491 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 930171011492 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 930171011493 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 930171011494 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 930171011495 active site 930171011496 catalytic residues [active] 930171011497 DNA binding site [nucleotide binding] 930171011498 Int/Topo IB signature motif; other site 930171011499 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 930171011500 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 930171011501 NlpC/P60 family; Region: NLPC_P60; cl17555 930171011502 ydaO-yuaA leader 930171011503 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 930171011504 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171011505 putative DNA binding site [nucleotide binding]; other site 930171011506 dimerization interface [polypeptide binding]; other site 930171011507 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930171011508 putative Zn2+ binding site [ion binding]; other site 930171011509 Cation efflux family; Region: Cation_efflux; cl00316 930171011510 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 930171011511 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 930171011512 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 930171011513 Copper resistance protein D; Region: CopD; pfam05425 930171011514 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 930171011515 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171011516 dimerization interface [polypeptide binding]; other site 930171011517 putative DNA binding site [nucleotide binding]; other site 930171011518 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930171011519 putative Zn2+ binding site [ion binding]; other site 930171011520 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 930171011521 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 930171011522 Thioredoxin; Region: Thioredoxin_4; pfam13462 930171011523 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 930171011524 CopC domain; Region: CopC; pfam04234 930171011525 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930171011526 putative Zn2+ binding site [ion binding]; other site 930171011527 putative DNA binding site [nucleotide binding]; other site 930171011528 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 930171011529 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 930171011530 FeoA domain; Region: FeoA; pfam04023 930171011531 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 930171011532 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 930171011533 Domain of unknown function DUF87; Region: DUF87; pfam01935 930171011534 HerA helicase [Replication, recombination, and repair]; Region: COG0433 930171011535 SIR2-like domain; Region: SIR2_2; pfam13289 930171011536 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 930171011537 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 930171011538 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 930171011539 AAA-like domain; Region: AAA_10; pfam12846 930171011540 Helix-turn-helix domain; Region: HTH_17; pfam12728 930171011541 CHAP domain; Region: CHAP; cl17642 930171011542 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 930171011543 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930171011544 ParA-like protein; Provisional; Region: PHA02518 930171011545 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930171011546 P-loop; other site 930171011547 Magnesium ion binding site [ion binding]; other site 930171011548 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 930171011549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930171011550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930171011551 DNA binding residues [nucleotide binding] 930171011552 multiple promoter invertase; Provisional; Region: mpi; PRK13413 930171011553 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 930171011554 catalytic residues [active] 930171011555 catalytic nucleophile [active] 930171011556 Presynaptic Site I dimer interface [polypeptide binding]; other site 930171011557 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 930171011558 Synaptic Flat tetramer interface [polypeptide binding]; other site 930171011559 Synaptic Site I dimer interface [polypeptide binding]; other site 930171011560 DNA binding site [nucleotide binding] 930171011561 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 930171011562 DNA-binding interface [nucleotide binding]; DNA binding site 930171011563 Homeodomain-like domain; Region: HTH_23; pfam13384 930171011564 Winged helix-turn helix; Region: HTH_29; pfam13551 930171011565 Homeodomain-like domain; Region: HTH_32; pfam13565 930171011566 Integrase core domain; Region: rve; pfam00665 930171011567 Integrase core domain; Region: rve_3; cl15866 930171011568 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 930171011569 AAA domain; Region: AAA_22; pfam13401 930171011570 Transposase, Mutator family; Region: Transposase_mut; pfam00872 930171011571 MULE transposase domain; Region: MULE; pfam10551 930171011572 multiple promoter invertase; Provisional; Region: mpi; PRK13413 930171011573 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 930171011574 catalytic residues [active] 930171011575 catalytic nucleophile [active] 930171011576 Presynaptic Site I dimer interface [polypeptide binding]; other site 930171011577 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 930171011578 Synaptic Flat tetramer interface [polypeptide binding]; other site 930171011579 Synaptic Site I dimer interface [polypeptide binding]; other site 930171011580 DNA binding site [nucleotide binding] 930171011581 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 930171011582 DNA-binding interface [nucleotide binding]; DNA binding site 930171011583 YaaC-like Protein; Region: YaaC; pfam14175 930171011584 Uracil DNA glycosylase superfamily; Region: UDG; pfam03167 930171011585 ligand binding site [chemical binding]; other site 930171011586 active site 930171011587 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 930171011588 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930171011589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930171011590 salt bridge; other site 930171011591 non-specific DNA binding site [nucleotide binding]; other site 930171011592 sequence-specific DNA binding site [nucleotide binding]; other site 930171011593 DNA methylase; Region: N6_N4_Mtase; pfam01555 930171011594 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 930171011595 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 930171011596 DNA methylase; Region: N6_N4_Mtase; cl17433 930171011597 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 930171011598 DNA methylase; Region: N6_N4_Mtase; pfam01555 930171011599 MoxR-like ATPases [General function prediction only]; Region: COG0714 930171011600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171011601 Walker A motif; other site 930171011602 ATP binding site [chemical binding]; other site 930171011603 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 930171011604 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 930171011605 DNA binding residues [nucleotide binding] 930171011606 dimer interface [polypeptide binding]; other site 930171011607 metal binding site [ion binding]; metal-binding site 930171011608 mercuric reductase; Region: MerA; TIGR02053 930171011609 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171011610 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930171011611 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 930171011612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930171011613 Walker A motif; other site 930171011614 ATP binding site [chemical binding]; other site 930171011615 Walker B motif; other site 930171011616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 930171011617 potential frameshift: common BLAST hit: gi|219883266|ref|YP_002478427.1| ATP dependent DNA ligase 930171011618 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 930171011619 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 930171011620 active site 930171011621 DNA binding site [nucleotide binding] 930171011622 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 930171011623 DNA binding site [nucleotide binding] 930171011624 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 930171011625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171011626 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171011627 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171011628 Transposase, Mutator family; Region: Transposase_mut; pfam00872 930171011629 MULE transposase domain; Region: MULE; pfam10551 930171011630 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 930171011631 ParB-like nuclease domain; Region: ParB; smart00470 930171011632 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 930171011633 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 930171011634 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 930171011635 catalytic residues [active] 930171011636 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930171011637 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930171011638 dimer interface [polypeptide binding]; other site 930171011639 ssDNA binding site [nucleotide binding]; other site 930171011640 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930171011641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171011642 ABC transporter signature motif; other site 930171011643 Walker B; other site 930171011644 D-loop; other site 930171011645 H-loop/switch region; other site 930171011646 Helix-turn-helix domain; Region: HTH_17; pfam12728 930171011647 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 930171011648 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 930171011649 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 930171011650 Transposase, Mutator family; Region: Transposase_mut; pfam00872 930171011651 MULE transposase domain; Region: MULE; pfam10551 930171011652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 930171011653 Transposase; Region: DEDD_Tnp_IS110; pfam01548 930171011654 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 930171011655 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 930171011656 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 930171011657 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 930171011658 active site 930171011659 DNA binding site [nucleotide binding] 930171011660 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 930171011661 DNA binding site [nucleotide binding] 930171011662 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 930171011663 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 930171011664 cofactor binding site; other site 930171011665 DNA binding site [nucleotide binding] 930171011666 substrate interaction site [chemical binding]; other site 930171011667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930171011668 ATP binding site [chemical binding]; other site 930171011669 Mg2+ binding site [ion binding]; other site 930171011670 G-X-G motif; other site 930171011671 Z1 domain; Region: Z1; pfam10593 930171011672 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 930171011673 AIPR protein; Region: AIPR; pfam10592 930171011674 DNA binding domain, excisionase family; Region: excise; TIGR01764 930171011675 Restriction endonuclease; Region: Mrr_cat; pfam04471 930171011676 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 930171011677 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 930171011678 Presynaptic Site I dimer interface [polypeptide binding]; other site 930171011679 catalytic residues [active] 930171011680 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 930171011681 Synaptic Flat tetramer interface [polypeptide binding]; other site 930171011682 Synaptic Site I dimer interface [polypeptide binding]; other site 930171011683 DNA binding site [nucleotide binding] 930171011684 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 930171011685 DNA-binding interface [nucleotide binding]; DNA binding site 930171011686 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930171011687 Magnesium ion binding site [ion binding]; other site 930171011688 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 930171011689 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930171011690 AAA domain; Region: AAA_31; pfam13614 930171011691 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930171011692 CHAP domain; Region: CHAP; cl17642 930171011693 Helix-turn-helix domain; Region: HTH_17; pfam12728 930171011694 AAA-like domain; Region: AAA_10; pfam12846 930171011695 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 930171011696 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 930171011697 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930171011698 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 930171011699 SIR2-like domain; Region: SIR2_2; pfam13289 930171011700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930171011701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930171011702 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 930171011703 substrate binding pocket [chemical binding]; other site 930171011704 dimerization interface [polypeptide binding]; other site 930171011705 Amidohydrolase; Region: Amidohydro_2; pfam04909 930171011706 hypothetical protein; Provisional; Region: PRK09262 930171011707 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 930171011708 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 930171011709 active site 930171011710 protocatechuate 4,5-dioxygenase; Provisional; Region: pcmA; PRK13372 930171011711 The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924 930171011712 tetramer interface [polypeptide binding]; other site 930171011713 dimer interface [polypeptide binding]; other site 930171011714 active site 930171011715 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 930171011716 active site 930171011717 Fe(II) binding site [ion binding]; other site 930171011718 dimer interface [polypeptide binding]; other site 930171011719 tetramer interface [polypeptide binding]; other site 930171011720 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930171011721 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930171011722 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171011723 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171011724 active site 930171011725 catalytic tetrad [active] 930171011726 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 930171011727 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 930171011728 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 930171011729 Transcriptional regulator [Transcription]; Region: IclR; COG1414 930171011730 Bacterial transcriptional regulator; Region: IclR; pfam01614 930171011731 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 930171011732 intersubunit interface [polypeptide binding]; other site 930171011733 active site 930171011734 Zn2+ binding site [ion binding]; other site 930171011735 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 930171011736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930171011737 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 930171011738 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 930171011739 inter-subunit interface; other site 930171011740 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 930171011741 alpha subunit interaction site [polypeptide binding]; other site 930171011742 beta subunit interaction site [polypeptide binding]; other site 930171011743 iron-sulfur cluster [ion binding]; other site 930171011744 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 930171011745 beta subunit interface [polypeptide binding]; other site 930171011746 alpha subunit interface [polypeptide binding]; other site 930171011747 active site 930171011748 substrate binding site [chemical binding]; other site 930171011749 Fe binding site [ion binding]; other site 930171011750 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930171011751 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930171011752 active site 930171011753 catalytic tetrad [active] 930171011754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171011755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171011756 Isochorismatase family; Region: Isochorismatase; pfam00857 930171011757 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 930171011758 catalytic triad [active] 930171011759 substrate binding site [chemical binding]; other site 930171011760 domain interfaces; other site 930171011761 conserved cis-peptide bond; other site 930171011762 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930171011763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171011764 dimer interface [polypeptide binding]; other site 930171011765 conserved gate region; other site 930171011766 ABC-ATPase subunit interface; other site 930171011767 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 930171011768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930171011769 dimer interface [polypeptide binding]; other site 930171011770 conserved gate region; other site 930171011771 putative PBP binding loops; other site 930171011772 ABC-ATPase subunit interface; other site 930171011773 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 930171011774 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 930171011775 Walker A/P-loop; other site 930171011776 ATP binding site [chemical binding]; other site 930171011777 Q-loop/lid; other site 930171011778 ABC transporter signature motif; other site 930171011779 Walker B; other site 930171011780 D-loop; other site 930171011781 H-loop/switch region; other site 930171011782 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 930171011783 NMT1/THI5 like; Region: NMT1; pfam09084 930171011784 membrane-bound complex binding site; other site 930171011785 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 930171011786 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 930171011787 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 930171011788 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930171011789 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 930171011790 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 930171011791 intersubunit interface [polypeptide binding]; other site 930171011792 active site 930171011793 Zn2+ binding site [ion binding]; other site 930171011794 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 930171011795 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 930171011796 inter-subunit interface; other site 930171011797 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 930171011798 iron-sulfur cluster [ion binding]; other site 930171011799 [2Fe-2S] cluster binding site [ion binding]; other site 930171011800 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 930171011801 beta subunit interface [polypeptide binding]; other site 930171011802 alpha subunit interface [polypeptide binding]; other site 930171011803 active site 930171011804 substrate binding site [chemical binding]; other site 930171011805 Fe binding site [ion binding]; other site 930171011806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 930171011807 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 930171011808 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 930171011809 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 930171011810 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930171011811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930171011812 DNA-binding site [nucleotide binding]; DNA binding site 930171011813 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 930171011814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930171011815 putative substrate translocation pore; other site 930171011816 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930171011817 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 930171011818 active site 930171011819 Int/Topo IB signature motif; other site 930171011820 DNA binding site [nucleotide binding] 930171011821 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 930171011822 potential frameshift: common BLAST hit: gi|315444130|ref|YP_004077009.1| site-specific recombinase XerD 930171011823 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930171011824 DNA binding site [nucleotide binding] 930171011825 active site 930171011826 Int/Topo IB signature motif; other site 930171011827 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 930171011828 Helix-turn-helix domain; Region: HTH_17; cl17695 930171011829 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 930171011830 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 930171011831 Transposase; Region: HTH_Tnp_1; cl17663 930171011832 Helix-turn-helix domain; Region: HTH_17; pfam12728 930171011833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930171011834 ABC transporter signature motif; other site 930171011835 Walker B; other site 930171011836 D-loop; other site 930171011837 H-loop/switch region; other site 930171011838 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930171011839 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930171011840 dimer interface [polypeptide binding]; other site 930171011841 ssDNA binding site [nucleotide binding]; other site 930171011842 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930171011843 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 930171011844 catalytic residues [active] 930171011845 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 930171011846 ParB-like nuclease domain; Region: ParB; smart00470 930171011847 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 930171011848 DNA protecting protein DprA; Region: dprA; TIGR00732 930171011849 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481