-- dump date 20140618_205746 -- class Genbank::misc_feature -- table misc_feature_note -- id note 573065000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 573065000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 573065000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065000004 Walker A motif; other site 573065000005 ATP binding site [chemical binding]; other site 573065000006 Walker B motif; other site 573065000007 arginine finger; other site 573065000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 573065000009 DnaA box-binding interface [nucleotide binding]; other site 573065000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 573065000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 573065000012 putative DNA binding surface [nucleotide binding]; other site 573065000013 dimer interface [polypeptide binding]; other site 573065000014 beta-clamp/clamp loader binding surface; other site 573065000015 beta-clamp/translesion DNA polymerase binding surface; other site 573065000016 recombination protein F; Reviewed; Region: recF; PRK00064 573065000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065000018 Walker A/P-loop; other site 573065000019 ATP binding site [chemical binding]; other site 573065000020 Q-loop/lid; other site 573065000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065000022 ABC transporter signature motif; other site 573065000023 Walker B; other site 573065000024 D-loop; other site 573065000025 H-loop/switch region; other site 573065000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 573065000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065000028 Mg2+ binding site [ion binding]; other site 573065000029 G-X-G motif; other site 573065000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573065000031 anchoring element; other site 573065000032 dimer interface [polypeptide binding]; other site 573065000033 ATP binding site [chemical binding]; other site 573065000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 573065000035 active site 573065000036 putative metal-binding site [ion binding]; other site 573065000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573065000038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065000039 non-specific DNA binding site [nucleotide binding]; other site 573065000040 salt bridge; other site 573065000041 sequence-specific DNA binding site [nucleotide binding]; other site 573065000042 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 573065000043 argininosuccinate synthase; Provisional; Region: PRK13820 573065000044 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 573065000045 ANP binding site [chemical binding]; other site 573065000046 Substrate Binding Site II [chemical binding]; other site 573065000047 Substrate Binding Site I [chemical binding]; other site 573065000048 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 573065000049 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 573065000050 potassium uptake protein; Region: kup; TIGR00794 573065000051 Transcriptional regulator; Region: Rrf2; pfam02082 573065000052 Rrf2 family protein; Region: rrf2_super; TIGR00738 573065000053 Transcriptional regulator; Region: Rrf2; cl17282 573065000054 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 573065000055 classical (c) SDRs; Region: SDR_c; cd05233 573065000056 NAD(P) binding site [chemical binding]; other site 573065000057 active site 573065000058 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 573065000059 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 573065000060 active site 573065000061 dimer interface [polypeptide binding]; other site 573065000062 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 573065000063 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 573065000064 Peptidase family M48; Region: Peptidase_M48; cl12018 573065000065 NusB family; Region: NusB; pfam01029 573065000066 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 573065000067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065000068 S-adenosylmethionine binding site [chemical binding]; other site 573065000069 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 573065000070 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 573065000071 substrate binding site [chemical binding]; other site 573065000072 hexamer interface [polypeptide binding]; other site 573065000073 metal binding site [ion binding]; metal-binding site 573065000074 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 573065000075 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 573065000076 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 573065000077 purine monophosphate binding site [chemical binding]; other site 573065000078 dimer interface [polypeptide binding]; other site 573065000079 putative catalytic residues [active] 573065000080 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 573065000081 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 573065000082 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 573065000083 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573065000084 Protein of unknown function (DUF461); Region: DUF461; pfam04314 573065000085 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 573065000086 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 573065000087 active site 573065000088 HIGH motif; other site 573065000089 dimer interface [polypeptide binding]; other site 573065000090 KMSKS motif; other site 573065000091 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 573065000092 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 573065000093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 573065000094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065000095 Coenzyme A binding pocket [chemical binding]; other site 573065000096 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 573065000097 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 573065000098 oligomeric interface; other site 573065000099 putative active site [active] 573065000100 homodimer interface [polypeptide binding]; other site 573065000101 HipA N-terminal domain; Region: Couple_hipA; pfam13657 573065000102 HipA-like N-terminal domain; Region: HipA_N; pfam07805 573065000103 HipA-like C-terminal domain; Region: HipA_C; pfam07804 573065000104 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 573065000105 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573065000106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065000107 putative active site [active] 573065000108 heme pocket [chemical binding]; other site 573065000109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065000110 putative active site [active] 573065000111 heme pocket [chemical binding]; other site 573065000112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065000113 PAS domain; Region: PAS_9; pfam13426 573065000114 putative active site [active] 573065000115 heme pocket [chemical binding]; other site 573065000116 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065000117 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065000118 dimer interface [polypeptide binding]; other site 573065000119 putative CheW interface [polypeptide binding]; other site 573065000120 PII uridylyl-transferase; Provisional; Region: PRK05092 573065000121 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 573065000122 metal binding triad; other site 573065000123 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 573065000124 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 573065000125 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 573065000126 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 573065000127 MutS domain I; Region: MutS_I; pfam01624 573065000128 MutS domain II; Region: MutS_II; pfam05188 573065000129 MutS domain III; Region: MutS_III; pfam05192 573065000130 MutS domain V; Region: MutS_V; pfam00488 573065000131 Walker A/P-loop; other site 573065000132 ATP binding site [chemical binding]; other site 573065000133 Q-loop/lid; other site 573065000134 ABC transporter signature motif; other site 573065000135 Walker B; other site 573065000136 D-loop; other site 573065000137 H-loop/switch region; other site 573065000138 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 573065000139 Malic enzyme, N-terminal domain; Region: malic; pfam00390 573065000140 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 573065000141 putative NAD(P) binding site [chemical binding]; other site 573065000142 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 573065000143 muropeptide transporter; Validated; Region: ampG; cl17669 573065000144 muropeptide transporter; Validated; Region: ampG; cl17669 573065000145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065000146 dimer interface [polypeptide binding]; other site 573065000147 phosphorylation site [posttranslational modification] 573065000148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065000149 ATP binding site [chemical binding]; other site 573065000150 Mg2+ binding site [ion binding]; other site 573065000151 G-X-G motif; other site 573065000152 Response regulator receiver domain; Region: Response_reg; pfam00072 573065000153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065000154 active site 573065000155 phosphorylation site [posttranslational modification] 573065000156 intermolecular recognition site; other site 573065000157 dimerization interface [polypeptide binding]; other site 573065000158 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 573065000159 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 573065000160 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573065000161 Walker A/P-loop; other site 573065000162 ATP binding site [chemical binding]; other site 573065000163 Q-loop/lid; other site 573065000164 ABC transporter signature motif; other site 573065000165 Walker B; other site 573065000166 D-loop; other site 573065000167 H-loop/switch region; other site 573065000168 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573065000169 FtsX-like permease family; Region: FtsX; pfam02687 573065000170 macrolide transporter subunit MacA; Provisional; Region: PRK11578 573065000171 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065000172 glutathione synthetase; Provisional; Region: PRK05246 573065000173 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 573065000174 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 573065000175 Predicted methyltransferases [General function prediction only]; Region: COG0313 573065000176 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 573065000177 putative SAM binding site [chemical binding]; other site 573065000178 putative homodimer interface [polypeptide binding]; other site 573065000179 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 573065000180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065000181 FeS/SAM binding site; other site 573065000182 HemN C-terminal domain; Region: HemN_C; pfam06969 573065000183 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 573065000184 active site 573065000185 dimerization interface [polypeptide binding]; other site 573065000186 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 573065000187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 573065000188 ribonuclease PH; Reviewed; Region: rph; PRK00173 573065000189 Ribonuclease PH; Region: RNase_PH_bact; cd11362 573065000190 hexamer interface [polypeptide binding]; other site 573065000191 active site 573065000192 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 573065000193 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 573065000194 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 573065000195 dimer interface [polypeptide binding]; other site 573065000196 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 573065000197 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 573065000198 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065000199 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 573065000200 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573065000201 nucleotide binding site [chemical binding]; other site 573065000202 chaperone protein DnaJ; Provisional; Region: PRK10767 573065000203 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573065000204 HSP70 interaction site [polypeptide binding]; other site 573065000205 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 573065000206 substrate binding site [polypeptide binding]; other site 573065000207 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573065000208 Zn binding sites [ion binding]; other site 573065000209 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573065000210 dimer interface [polypeptide binding]; other site 573065000211 dihydrodipicolinate reductase; Provisional; Region: PRK00048 573065000212 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 573065000213 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 573065000214 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 573065000215 trimer interface [polypeptide binding]; other site 573065000216 active site 573065000217 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 573065000218 Flavoprotein; Region: Flavoprotein; pfam02441 573065000219 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 573065000220 Pyocin large subunit [General function prediction only]; Region: COG5529 573065000221 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 573065000222 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573065000223 metal binding site [ion binding]; metal-binding site 573065000224 active site 573065000225 I-site; other site 573065000226 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573065000227 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 573065000228 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 573065000229 Cl binding site [ion binding]; other site 573065000230 oligomer interface [polypeptide binding]; other site 573065000231 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573065000232 HAMP domain; Region: HAMP; pfam00672 573065000233 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 573065000234 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065000235 dimer interface [polypeptide binding]; other site 573065000236 putative CheW interface [polypeptide binding]; other site 573065000237 ABC1 family; Region: ABC1; cl17513 573065000238 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 573065000239 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 573065000240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065000241 S-adenosylmethionine binding site [chemical binding]; other site 573065000242 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 573065000243 EF-hand domain pair; Region: EF_hand_5; pfam13499 573065000244 Ca2+ binding site [ion binding]; other site 573065000245 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573065000246 MULE transposase domain; Region: MULE; pfam10551 573065000247 Predicted transcriptional regulator [Transcription]; Region: COG2944 573065000248 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573065000249 active site 573065000250 NTP binding site [chemical binding]; other site 573065000251 metal binding triad [ion binding]; metal-binding site 573065000252 antibiotic binding site [chemical binding]; other site 573065000253 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 573065000254 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573065000255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573065000256 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573065000257 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573065000258 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 573065000259 putative acyl-acceptor binding pocket; other site 573065000260 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 573065000261 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 573065000262 Phosphotransferase enzyme family; Region: APH; pfam01636 573065000263 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 573065000264 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 573065000265 Substrate binding site; other site 573065000266 metal-binding site 573065000267 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 573065000268 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 573065000269 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 573065000270 Part of AAA domain; Region: AAA_19; pfam13245 573065000271 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573065000272 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573065000273 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573065000274 catalytic residues [active] 573065000275 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 573065000276 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 573065000277 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573065000278 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573065000279 active site 573065000280 metal binding site [ion binding]; metal-binding site 573065000281 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 573065000282 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 573065000283 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 573065000284 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 573065000285 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 573065000286 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 573065000287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065000288 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065000289 non-specific DNA binding site [nucleotide binding]; other site 573065000290 salt bridge; other site 573065000291 sequence-specific DNA binding site [nucleotide binding]; other site 573065000292 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 573065000293 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 573065000294 active site 573065000295 substrate binding site [chemical binding]; other site 573065000296 metal binding site [ion binding]; metal-binding site 573065000297 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 573065000298 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 573065000299 glutaminase active site [active] 573065000300 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573065000301 dimer interface [polypeptide binding]; other site 573065000302 active site 573065000303 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 573065000304 dimer interface [polypeptide binding]; other site 573065000305 active site 573065000306 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065000307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065000308 non-specific DNA binding site [nucleotide binding]; other site 573065000309 salt bridge; other site 573065000310 sequence-specific DNA binding site [nucleotide binding]; other site 573065000311 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573065000312 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573065000313 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 573065000314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 573065000315 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 573065000316 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 573065000317 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573065000318 MarR family; Region: MarR_2; pfam12802 573065000319 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573065000320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573065000321 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 573065000322 putative deacylase active site [active] 573065000323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065000324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065000325 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 573065000326 putative effector binding pocket; other site 573065000327 putative dimerization interface [polypeptide binding]; other site 573065000328 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 573065000329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065000330 NAD(P) binding site [chemical binding]; other site 573065000331 active site 573065000332 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 573065000333 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 573065000334 FAD binding pocket [chemical binding]; other site 573065000335 FAD binding motif [chemical binding]; other site 573065000336 phosphate binding motif [ion binding]; other site 573065000337 NAD binding pocket [chemical binding]; other site 573065000338 Predicted transcriptional regulators [Transcription]; Region: COG1695 573065000339 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573065000340 RimM N-terminal domain; Region: RimM; pfam01782 573065000341 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 573065000342 PRC-barrel domain; Region: PRC; pfam05239 573065000343 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 573065000344 intersubunit interactions; other site 573065000345 active site 573065000346 catalytic residue [active] 573065000347 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 573065000348 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573065000349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065000350 FeS/SAM binding site; other site 573065000351 TRAM domain; Region: TRAM; cl01282 573065000352 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 573065000353 trimer interface [polypeptide binding]; other site 573065000354 active site 573065000355 substrate binding site [chemical binding]; other site 573065000356 CoA binding site [chemical binding]; other site 573065000357 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573065000358 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 573065000359 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 573065000360 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 573065000361 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 573065000362 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573065000363 active site 573065000364 phosphorylation site [posttranslational modification] 573065000365 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 573065000366 30S subunit binding site; other site 573065000367 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 573065000368 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 573065000369 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 573065000370 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 573065000371 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 573065000372 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 573065000373 Walker A/P-loop; other site 573065000374 ATP binding site [chemical binding]; other site 573065000375 Q-loop/lid; other site 573065000376 ABC transporter signature motif; other site 573065000377 Walker B; other site 573065000378 D-loop; other site 573065000379 H-loop/switch region; other site 573065000380 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 573065000381 OstA-like protein; Region: OstA; pfam03968 573065000382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 573065000383 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 573065000384 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 573065000385 catalytic site [active] 573065000386 putative active site [active] 573065000387 putative substrate binding site [chemical binding]; other site 573065000388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065000389 putative substrate translocation pore; other site 573065000390 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 573065000391 putative catalytic site [active] 573065000392 putative phosphate binding site [ion binding]; other site 573065000393 active site 573065000394 metal binding site A [ion binding]; metal-binding site 573065000395 DNA binding site [nucleotide binding] 573065000396 putative AP binding site [nucleotide binding]; other site 573065000397 putative metal binding site B [ion binding]; other site 573065000398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573065000399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065000400 active site 573065000401 phosphorylation site [posttranslational modification] 573065000402 intermolecular recognition site; other site 573065000403 dimerization interface [polypeptide binding]; other site 573065000404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065000405 DNA binding site [nucleotide binding] 573065000406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 573065000407 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 573065000408 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573065000409 catalytic residue [active] 573065000410 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 573065000411 thiamine phosphate binding site [chemical binding]; other site 573065000412 active site 573065000413 pyrophosphate binding site [ion binding]; other site 573065000414 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 573065000415 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 573065000416 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 573065000417 HIGH motif; other site 573065000418 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573065000419 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573065000420 active site 573065000421 KMSKS motif; other site 573065000422 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 573065000423 tRNA binding surface [nucleotide binding]; other site 573065000424 Lipopolysaccharide-assembly; Region: LptE; cl01125 573065000425 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 573065000426 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 573065000427 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 573065000428 ParB-like nuclease domain; Region: ParBc; pfam02195 573065000429 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573065000430 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573065000431 P-loop; other site 573065000432 Magnesium ion binding site [ion binding]; other site 573065000433 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573065000434 Magnesium ion binding site [ion binding]; other site 573065000435 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 573065000436 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 573065000437 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 573065000438 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 573065000439 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 573065000440 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 573065000441 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 573065000442 trmE is a tRNA modification GTPase; Region: trmE; cd04164 573065000443 G1 box; other site 573065000444 GTP/Mg2+ binding site [chemical binding]; other site 573065000445 Switch I region; other site 573065000446 G2 box; other site 573065000447 Switch II region; other site 573065000448 G3 box; other site 573065000449 G4 box; other site 573065000450 G5 box; other site 573065000451 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 573065000452 transcription termination factor Rho; Provisional; Region: rho; PRK09376 573065000453 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 573065000454 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 573065000455 RNA binding site [nucleotide binding]; other site 573065000456 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 573065000457 multimer interface [polypeptide binding]; other site 573065000458 Walker A motif; other site 573065000459 ATP binding site [chemical binding]; other site 573065000460 Walker B motif; other site 573065000461 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 573065000462 Ferrochelatase; Region: Ferrochelatase; pfam00762 573065000463 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 573065000464 C-terminal domain interface [polypeptide binding]; other site 573065000465 active site 573065000466 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 573065000467 active site 573065000468 N-terminal domain interface [polypeptide binding]; other site 573065000469 uroporphyrinogen decarboxylase; Validated; Region: hemE; PRK00115 573065000470 PEP synthetase regulatory protein; Provisional; Region: PRK05339 573065000471 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 573065000472 active site 573065000473 dimer interface [polypeptide binding]; other site 573065000474 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 573065000475 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 573065000476 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 573065000477 NAD(P) binding site [chemical binding]; other site 573065000478 shikimate binding site; other site 573065000479 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 573065000480 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 573065000481 CoA-binding site [chemical binding]; other site 573065000482 ATP-binding [chemical binding]; other site 573065000483 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 573065000484 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 573065000485 active site 573065000486 catalytic site [active] 573065000487 substrate binding site [chemical binding]; other site 573065000488 preprotein translocase subunit SecB; Validated; Region: PRK05751 573065000489 SecA binding site; other site 573065000490 Preprotein binding site; other site 573065000491 Tim44-like domain; Region: Tim44; pfam04280 573065000492 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 573065000493 MltA specific insert domain; Region: MltA; smart00925 573065000494 3D domain; Region: 3D; pfam06725 573065000495 MAPEG family; Region: MAPEG; cl09190 573065000496 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 573065000497 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 573065000498 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 573065000499 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573065000500 Ligand Binding Site [chemical binding]; other site 573065000501 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 573065000502 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 573065000503 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 573065000504 Glycoprotease family; Region: Peptidase_M22; pfam00814 573065000505 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 573065000506 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573065000507 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573065000508 metal binding site 2 [ion binding]; metal-binding site 573065000509 putative DNA binding helix; other site 573065000510 metal binding site 1 [ion binding]; metal-binding site 573065000511 dimer interface [polypeptide binding]; other site 573065000512 structural Zn2+ binding site [ion binding]; other site 573065000513 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 573065000514 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 573065000515 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 573065000516 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573065000517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065000518 FeS/SAM binding site; other site 573065000519 TRAM domain; Region: TRAM; cl01282 573065000520 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 573065000521 PhoH-like protein; Region: PhoH; pfam02562 573065000522 metal-binding heat shock protein; Provisional; Region: PRK00016 573065000523 FOG: CBS domain [General function prediction only]; Region: COG0517 573065000524 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573065000525 Transporter associated domain; Region: CorC_HlyC; smart01091 573065000526 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 573065000527 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 573065000528 putative active site [active] 573065000529 catalytic triad [active] 573065000530 putative dimer interface [polypeptide binding]; other site 573065000531 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065000532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065000533 non-specific DNA binding site [nucleotide binding]; other site 573065000534 salt bridge; other site 573065000535 sequence-specific DNA binding site [nucleotide binding]; other site 573065000536 S-adenosylmethionine synthetase; Validated; Region: PRK05250 573065000537 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 573065000538 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 573065000539 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 573065000540 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 573065000541 Sm and related proteins; Region: Sm_like; cl00259 573065000542 ribosome maturation protein RimP; Reviewed; Region: PRK00092 573065000543 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 573065000544 putative oligomer interface [polypeptide binding]; other site 573065000545 putative RNA binding site [nucleotide binding]; other site 573065000546 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 573065000547 NusA N-terminal domain; Region: NusA_N; pfam08529 573065000548 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 573065000549 RNA binding site [nucleotide binding]; other site 573065000550 homodimer interface [polypeptide binding]; other site 573065000551 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 573065000552 G-X-X-G motif; other site 573065000553 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 573065000554 G-X-X-G motif; other site 573065000555 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 573065000556 hypothetical protein; Provisional; Region: PRK09190 573065000557 Protein of unknown function (DUF448); Region: DUF448; pfam04296 573065000558 putative RNA binding cleft [nucleotide binding]; other site 573065000559 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 573065000560 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 573065000561 translation initiation factor IF-2; Region: IF-2; TIGR00487 573065000562 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573065000563 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 573065000564 G1 box; other site 573065000565 putative GEF interaction site [polypeptide binding]; other site 573065000566 GTP/Mg2+ binding site [chemical binding]; other site 573065000567 Switch I region; other site 573065000568 G2 box; other site 573065000569 G3 box; other site 573065000570 Switch II region; other site 573065000571 G4 box; other site 573065000572 G5 box; other site 573065000573 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 573065000574 Translation-initiation factor 2; Region: IF-2; pfam11987 573065000575 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 573065000576 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 573065000577 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 573065000578 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 573065000579 putative active site [active] 573065000580 putative substrate binding site [chemical binding]; other site 573065000581 putative cosubstrate binding site; other site 573065000582 catalytic site [active] 573065000583 Predicted membrane protein [Function unknown]; Region: COG2311 573065000584 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 573065000585 Protein of unknown function (DUF418); Region: DUF418; pfam04235 573065000586 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 573065000587 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 573065000588 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 573065000589 RNA binding site [nucleotide binding]; other site 573065000590 active site 573065000591 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 573065000592 16S/18S rRNA binding site [nucleotide binding]; other site 573065000593 S13e-L30e interaction site [polypeptide binding]; other site 573065000594 25S rRNA binding site [nucleotide binding]; other site 573065000595 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 573065000596 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 573065000597 RNase E interface [polypeptide binding]; other site 573065000598 trimer interface [polypeptide binding]; other site 573065000599 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 573065000600 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 573065000601 RNase E interface [polypeptide binding]; other site 573065000602 trimer interface [polypeptide binding]; other site 573065000603 active site 573065000604 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 573065000605 putative nucleic acid binding region [nucleotide binding]; other site 573065000606 G-X-X-G motif; other site 573065000607 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 573065000608 RNA binding site [nucleotide binding]; other site 573065000609 domain interface; other site 573065000610 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573065000611 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573065000612 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573065000613 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065000614 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065000615 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065000616 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 573065000617 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 573065000618 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 573065000619 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 573065000620 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065000621 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065000622 N-terminal plug; other site 573065000623 ligand-binding site [chemical binding]; other site 573065000624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065000625 Response regulator receiver domain; Region: Response_reg; pfam00072 573065000626 active site 573065000627 phosphorylation site [posttranslational modification] 573065000628 intermolecular recognition site; other site 573065000629 dimerization interface [polypeptide binding]; other site 573065000630 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 573065000631 MG2 domain; Region: A2M_N; pfam01835 573065000632 Alpha-2-macroglobulin family; Region: A2M; pfam00207 573065000633 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 573065000634 surface patch; other site 573065000635 thioester region; other site 573065000636 specificity defining residues; other site 573065000637 Transglycosylase; Region: Transgly; pfam00912 573065000638 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 573065000639 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573065000640 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 573065000641 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 573065000642 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 573065000643 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573065000644 homotrimer interaction site [polypeptide binding]; other site 573065000645 putative active site [active] 573065000646 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 573065000647 signal recognition particle protein; Provisional; Region: PRK10867 573065000648 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 573065000649 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573065000650 P loop; other site 573065000651 GTP binding site [chemical binding]; other site 573065000652 Signal peptide binding domain; Region: SRP_SPB; pfam02978 573065000653 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065000654 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573065000655 aminotransferase; Validated; Region: PRK09148 573065000656 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573065000657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065000658 homodimer interface [polypeptide binding]; other site 573065000659 catalytic residue [active] 573065000660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573065000661 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573065000662 malate dehydrogenase; Reviewed; Region: PRK06223 573065000663 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 573065000664 NAD(P) binding site [chemical binding]; other site 573065000665 dimer interface [polypeptide binding]; other site 573065000666 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573065000667 substrate binding site [chemical binding]; other site 573065000668 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 573065000669 nucleotide binding site/active site [active] 573065000670 HIT family signature motif; other site 573065000671 catalytic residue [active] 573065000672 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 573065000673 Iron-sulfur protein interface; other site 573065000674 proximal quinone binding site [chemical binding]; other site 573065000675 SdhD (CybS) interface [polypeptide binding]; other site 573065000676 proximal heme binding site [chemical binding]; other site 573065000677 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 573065000678 Iron-sulfur protein interface; other site 573065000679 proximal heme binding site [chemical binding]; other site 573065000680 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 573065000681 L-aspartate oxidase; Provisional; Region: PRK06175 573065000682 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573065000683 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 573065000684 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573065000685 catalytic loop [active] 573065000686 iron binding site [ion binding]; other site 573065000687 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 573065000688 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573065000689 catalytic loop [active] 573065000690 iron binding site [ion binding]; other site 573065000691 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 573065000692 HPP family; Region: HPP; pfam04982 573065000693 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573065000694 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 573065000695 inner membrane protein; Provisional; Region: PRK11715 573065000696 PAS fold; Region: PAS_7; pfam12860 573065000697 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573065000698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065000699 dimer interface [polypeptide binding]; other site 573065000700 phosphorylation site [posttranslational modification] 573065000701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065000702 ATP binding site [chemical binding]; other site 573065000703 Mg2+ binding site [ion binding]; other site 573065000704 G-X-G motif; other site 573065000705 Predicted integral membrane protein [Function unknown]; Region: COG5658 573065000706 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 573065000707 SdpI/YhfL protein family; Region: SdpI; pfam13630 573065000708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065000709 putative DNA binding site [nucleotide binding]; other site 573065000710 dimerization interface [polypeptide binding]; other site 573065000711 putative Zn2+ binding site [ion binding]; other site 573065000712 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 573065000713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065000714 active site 573065000715 phosphorylation site [posttranslational modification] 573065000716 intermolecular recognition site; other site 573065000717 dimerization interface [polypeptide binding]; other site 573065000718 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 573065000719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065000720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 573065000721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065000722 ATP binding site [chemical binding]; other site 573065000723 Mg2+ binding site [ion binding]; other site 573065000724 G-X-G motif; other site 573065000725 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 573065000726 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 573065000727 Cu(I) binding site [ion binding]; other site 573065000728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 573065000729 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 573065000730 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 573065000731 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 573065000732 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 573065000733 Protein of unknown function DUF45; Region: DUF45; pfam01863 573065000734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065000735 dimerization interface [polypeptide binding]; other site 573065000736 putative DNA binding site [nucleotide binding]; other site 573065000737 putative Zn2+ binding site [ion binding]; other site 573065000738 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 573065000739 hydrophobic ligand binding site; other site 573065000740 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 573065000741 putative hydrophobic ligand binding site [chemical binding]; other site 573065000742 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 573065000743 putative hydrophobic ligand binding site [chemical binding]; other site 573065000744 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573065000745 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 573065000746 dimer interface [polypeptide binding]; other site 573065000747 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 573065000748 putative hydrophobic ligand binding site [chemical binding]; other site 573065000749 Uncharacterized conserved protein [Function unknown]; Region: COG2353 573065000750 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 573065000751 putative hydrophobic ligand binding site [chemical binding]; other site 573065000752 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 573065000753 LytTr DNA-binding domain; Region: LytTR; smart00850 573065000754 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 573065000755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065000756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573065000757 putative substrate translocation pore; other site 573065000758 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 573065000759 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 573065000760 CoA-ligase; Region: Ligase_CoA; pfam00549 573065000761 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 573065000762 CoA binding domain; Region: CoA_binding; smart00881 573065000763 CoA-ligase; Region: Ligase_CoA; pfam00549 573065000764 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 573065000765 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 573065000766 TPP-binding site [chemical binding]; other site 573065000767 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 573065000768 dimer interface [polypeptide binding]; other site 573065000769 PYR/PP interface [polypeptide binding]; other site 573065000770 TPP binding site [chemical binding]; other site 573065000771 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573065000772 E3 interaction surface; other site 573065000773 lipoyl attachment site [posttranslational modification]; other site 573065000774 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 573065000775 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573065000776 E3 interaction surface; other site 573065000777 lipoyl attachment site [posttranslational modification]; other site 573065000778 e3 binding domain; Region: E3_binding; pfam02817 573065000779 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 573065000780 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 573065000781 nucleophile elbow; other site 573065000782 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 573065000783 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573065000784 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573065000785 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573065000786 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573065000787 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 573065000788 NAD binding site [chemical binding]; other site 573065000789 putative substrate binding site 2 [chemical binding]; other site 573065000790 putative substrate binding site 1 [chemical binding]; other site 573065000791 active site 573065000792 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 573065000793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065000794 binding surface 573065000795 TPR motif; other site 573065000796 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 573065000797 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 573065000798 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 573065000799 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573065000800 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 573065000801 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573065000802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573065000803 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573065000804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573065000805 Transposase; Region: HTH_Tnp_1; pfam01527 573065000806 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065000807 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065000808 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065000809 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 573065000810 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573065000811 active site 573065000812 DNA binding site [nucleotide binding] 573065000813 Int/Topo IB signature motif; other site 573065000814 Protein of unknown function, DUF484; Region: DUF484; cl17449 573065000815 primosome assembly protein PriA; Validated; Region: PRK05580 573065000816 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573065000817 ATP binding site [chemical binding]; other site 573065000818 putative Mg++ binding site [ion binding]; other site 573065000819 helicase superfamily c-terminal domain; Region: HELICc; smart00490 573065000820 ATP-binding site [chemical binding]; other site 573065000821 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 573065000822 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 573065000823 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 573065000824 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 573065000825 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573065000826 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 573065000827 beta subunit interaction interface [polypeptide binding]; other site 573065000828 Walker A motif; other site 573065000829 ATP binding site [chemical binding]; other site 573065000830 Walker B motif; other site 573065000831 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573065000832 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 573065000833 core domain interface [polypeptide binding]; other site 573065000834 delta subunit interface [polypeptide binding]; other site 573065000835 epsilon subunit interface [polypeptide binding]; other site 573065000836 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 573065000837 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573065000838 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 573065000839 alpha subunit interaction interface [polypeptide binding]; other site 573065000840 Walker A motif; other site 573065000841 ATP binding site [chemical binding]; other site 573065000842 Walker B motif; other site 573065000843 inhibitor binding site; inhibition site 573065000844 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573065000845 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 573065000846 gamma subunit interface [polypeptide binding]; other site 573065000847 epsilon subunit interface [polypeptide binding]; other site 573065000848 LBP interface [polypeptide binding]; other site 573065000849 Uncharacterized conserved protein [Function unknown]; Region: COG3287 573065000850 FIST N domain; Region: FIST; pfam08495 573065000851 FIST C domain; Region: FIST_C; pfam10442 573065000852 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065000853 dimer interface [polypeptide binding]; other site 573065000854 putative CheW interface [polypeptide binding]; other site 573065000855 Uncharacterized conserved protein [Function unknown]; Region: COG5470 573065000856 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 573065000857 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 573065000858 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 573065000859 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 573065000860 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573065000861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065000862 FeS/SAM binding site; other site 573065000863 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 573065000864 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 573065000865 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573065000866 P loop; other site 573065000867 GTP binding site [chemical binding]; other site 573065000868 Intracellular septation protein A; Region: IspA; cl01098 573065000869 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573065000870 MarR family; Region: MarR_2; pfam12802 573065000871 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 573065000872 classical (c) SDRs; Region: SDR_c; cd05233 573065000873 NAD(P) binding site [chemical binding]; other site 573065000874 active site 573065000875 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 573065000876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065000877 dimer interface [polypeptide binding]; other site 573065000878 conserved gate region; other site 573065000879 putative PBP binding loops; other site 573065000880 ABC-ATPase subunit interface; other site 573065000881 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 573065000882 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 573065000883 substrate binding pocket [chemical binding]; other site 573065000884 membrane-bound complex binding site; other site 573065000885 hinge residues; other site 573065000886 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 573065000887 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 573065000888 Walker A/P-loop; other site 573065000889 ATP binding site [chemical binding]; other site 573065000890 Q-loop/lid; other site 573065000891 ABC transporter signature motif; other site 573065000892 Walker B; other site 573065000893 D-loop; other site 573065000894 H-loop/switch region; other site 573065000895 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573065000896 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065000897 dimer interface [polypeptide binding]; other site 573065000898 putative CheW interface [polypeptide binding]; other site 573065000899 PilZ domain; Region: PilZ; pfam07238 573065000900 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 573065000901 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 573065000902 active site 573065000903 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573065000904 dimer interface [polypeptide binding]; other site 573065000905 catalytic residues [active] 573065000906 substrate binding site [chemical binding]; other site 573065000907 Predicted transcriptional regulator [Transcription]; Region: COG1959 573065000908 Transcriptional regulator; Region: Rrf2; pfam02082 573065000909 Transcriptional regulator; Region: Rrf2; cl17282 573065000910 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 573065000911 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 573065000912 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492 573065000913 deoxyhypusine synthase; Region: dhys; TIGR00321 573065000914 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 573065000915 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065000916 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065000917 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 573065000918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065000919 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 573065000920 tetramerization interface [polypeptide binding]; other site 573065000921 active site 573065000922 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 573065000923 Class I ribonucleotide reductase; Region: RNR_I; cd01679 573065000924 active site 573065000925 dimer interface [polypeptide binding]; other site 573065000926 catalytic residues [active] 573065000927 effector binding site; other site 573065000928 R2 peptide binding site; other site 573065000929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065000930 Coenzyme A binding pocket [chemical binding]; other site 573065000931 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 573065000932 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 573065000933 HD domain; Region: HD_5; pfam13487 573065000934 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573065000935 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573065000936 Zn2+ binding site [ion binding]; other site 573065000937 Mg2+ binding site [ion binding]; other site 573065000938 fructose-1,6-bisphosphatase family protein; Region: PLN02628 573065000939 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 573065000940 AMP binding site [chemical binding]; other site 573065000941 metal binding site [ion binding]; metal-binding site 573065000942 active site 573065000943 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 573065000944 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 573065000945 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 573065000946 putative active site [active] 573065000947 Ap4A binding site [chemical binding]; other site 573065000948 nudix motif; other site 573065000949 putative metal binding site [ion binding]; other site 573065000950 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 573065000951 NodB motif; other site 573065000952 putative active site [active] 573065000953 putative catalytic site [active] 573065000954 Zn binding site [ion binding]; other site 573065000955 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 573065000956 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573065000957 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573065000958 active site 573065000959 catalytic residues [active] 573065000960 DNA binding site [nucleotide binding] 573065000961 Int/Topo IB signature motif; other site 573065000962 Helix-turn-helix domain; Region: HTH_17; cl17695 573065000963 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 573065000964 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573065000965 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573065000966 dimer interface [polypeptide binding]; other site 573065000967 ssDNA binding site [nucleotide binding]; other site 573065000968 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573065000969 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 573065000970 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573065000971 Catalytic site [active] 573065000972 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 573065000973 GcrA cell cycle regulator; Region: GcrA; cl11564 573065000974 CHC2 zinc finger; Region: zf-CHC2; cl17510 573065000975 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 573065000976 D5 N terminal like; Region: D5_N; pfam08706 573065000977 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 573065000978 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 573065000979 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 573065000980 transcriptional activator RfaH; Region: RfaH; TIGR01955 573065000981 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 573065000982 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 573065000983 Phage-related protein [Function unknown]; Region: COG4695; cl01923 573065000984 Phage portal protein; Region: Phage_portal; pfam04860 573065000985 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 573065000986 oligomer interface [polypeptide binding]; other site 573065000987 active site residues [active] 573065000988 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 573065000989 Phage capsid family; Region: Phage_capsid; pfam05065 573065000990 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 573065000991 oligomerization interface [polypeptide binding]; other site 573065000992 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 573065000993 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 573065000994 Phage major tail protein 2; Region: Phage_tail_2; cl11463 573065000995 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 573065000996 tape measure domain; Region: tape_meas_nterm; TIGR02675 573065000997 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573065000998 Interdomain contacts; other site 573065000999 Cytokine receptor motif; other site 573065001000 TIGR02594 family protein; Region: TIGR02594 573065001001 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 573065001002 rod shape-determining protein MreC; Provisional; Region: PRK13922 573065001003 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 573065001004 AMP nucleosidase; Provisional; Region: PRK08292 573065001005 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 573065001006 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 573065001007 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573065001008 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065001009 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 573065001010 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 573065001011 Cytochrome P450; Region: p450; cl12078 573065001012 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573065001013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001014 active site 573065001015 phosphorylation site [posttranslational modification] 573065001016 intermolecular recognition site; other site 573065001017 dimerization interface [polypeptide binding]; other site 573065001018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 573065001019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065001020 ATP binding site [chemical binding]; other site 573065001021 Mg2+ binding site [ion binding]; other site 573065001022 G-X-G motif; other site 573065001023 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 573065001024 metal binding site [ion binding]; metal-binding site 573065001025 active site 573065001026 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065001027 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065001028 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 573065001029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573065001030 Helix-turn-helix domain; Region: HTH_28; pfam13518 573065001031 Helix-turn-helix domain; Region: HTH_28; pfam13518 573065001032 putative transposase OrfB; Reviewed; Region: PHA02517 573065001033 HTH-like domain; Region: HTH_21; pfam13276 573065001034 Integrase core domain; Region: rve; pfam00665 573065001035 Integrase core domain; Region: rve_2; pfam13333 573065001036 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 573065001037 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 573065001038 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 573065001039 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 573065001040 dimer interface [polypeptide binding]; other site 573065001041 Alkaline phosphatase homologues; Region: alkPPc; smart00098 573065001042 active site 573065001043 Predicted ATPase [General function prediction only]; Region: COG1485 573065001044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065001045 Walker B; other site 573065001046 D-loop; other site 573065001047 H-loop/switch region; other site 573065001048 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 573065001049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573065001050 Response regulator receiver domain; Region: Response_reg; pfam00072 573065001051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001052 active site 573065001053 phosphorylation site [posttranslational modification] 573065001054 intermolecular recognition site; other site 573065001055 dimerization interface [polypeptide binding]; other site 573065001056 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 573065001057 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573065001058 Predicted permeases [General function prediction only]; Region: RarD; COG2962 573065001059 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573065001060 Beta-lactamase; Region: Beta-lactamase; pfam00144 573065001061 Predicted methyltransferase [General function prediction only]; Region: COG4798 573065001062 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573065001063 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 573065001064 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573065001065 molybdopterin cofactor binding site; other site 573065001066 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 573065001067 molybdopterin cofactor binding site; other site 573065001068 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573065001069 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065001070 Yip1 domain; Region: Yip1; pfam04893 573065001071 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 573065001072 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 573065001073 dimer interface [polypeptide binding]; other site 573065001074 putative functional site; other site 573065001075 putative MPT binding site; other site 573065001076 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 573065001077 MPT binding site; other site 573065001078 trimer interface [polypeptide binding]; other site 573065001079 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 573065001080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065001081 FeS/SAM binding site; other site 573065001082 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 573065001083 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 573065001084 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573065001085 substrate binding pocket [chemical binding]; other site 573065001086 catalytic triad [active] 573065001087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573065001088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065001089 Coenzyme A binding pocket [chemical binding]; other site 573065001090 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065001091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 573065001092 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 573065001093 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573065001094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065001095 DNA-binding site [nucleotide binding]; DNA binding site 573065001096 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573065001097 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573065001098 dimerization domain swap beta strand [polypeptide binding]; other site 573065001099 regulatory protein interface [polypeptide binding]; other site 573065001100 active site 573065001101 regulatory phosphorylation site [posttranslational modification]; other site 573065001102 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 573065001103 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 573065001104 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 573065001105 active site 573065001106 (T/H)XGH motif; other site 573065001107 GTPase CgtA; Reviewed; Region: obgE; PRK12299 573065001108 GTP1/OBG; Region: GTP1_OBG; pfam01018 573065001109 Obg GTPase; Region: Obg; cd01898 573065001110 G1 box; other site 573065001111 GTP/Mg2+ binding site [chemical binding]; other site 573065001112 Switch I region; other site 573065001113 G2 box; other site 573065001114 G3 box; other site 573065001115 Switch II region; other site 573065001116 G4 box; other site 573065001117 G5 box; other site 573065001118 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573065001119 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573065001120 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 573065001121 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 573065001122 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 573065001123 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 573065001124 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 573065001125 P-loop, Walker A motif; other site 573065001126 Base recognition motif; other site 573065001127 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 573065001128 FOG: WD40 repeat [General function prediction only]; Region: COG2319 573065001129 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 573065001130 structural tetrad; other site 573065001131 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 573065001132 Transglycosylase; Region: Transgly; cl17702 573065001133 hypothetical protein; Validated; Region: PRK00124 573065001134 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 573065001135 active site 573065001136 Zn binding site [ion binding]; other site 573065001137 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 573065001138 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 573065001139 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 573065001140 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 573065001141 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573065001142 putative outer membrane lipoprotein; Provisional; Region: PRK10510 573065001143 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573065001144 ligand binding site [chemical binding]; other site 573065001145 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 573065001146 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 573065001147 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 573065001148 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 573065001149 NAD(P) binding site [chemical binding]; other site 573065001150 homodimer interface [polypeptide binding]; other site 573065001151 substrate binding site [chemical binding]; other site 573065001152 active site 573065001153 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 573065001154 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573065001155 inhibitor-cofactor binding pocket; inhibition site 573065001156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065001157 catalytic residue [active] 573065001158 pseudaminic acid synthase; Region: PseI; TIGR03586 573065001159 NeuB family; Region: NeuB; pfam03102 573065001160 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 573065001161 NeuB binding interface [polypeptide binding]; other site 573065001162 putative substrate binding site [chemical binding]; other site 573065001163 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 573065001164 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 573065001165 active site 573065001166 catalytic site [active] 573065001167 substrate binding site [chemical binding]; other site 573065001168 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 573065001169 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 573065001170 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573065001171 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 573065001172 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 573065001173 ATP binding site [chemical binding]; other site 573065001174 Walker A motif; other site 573065001175 hexamer interface [polypeptide binding]; other site 573065001176 Walker B motif; other site 573065001177 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 573065001178 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 573065001179 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573065001180 Type IV pili component [Cell motility and secretion]; Region: COG5461 573065001181 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 573065001182 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 573065001183 BON domain; Region: BON; pfam04972 573065001184 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 573065001185 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 573065001186 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 573065001187 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 573065001188 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 573065001189 Flp/Fap pilin component; Region: Flp_Fap; cl01585 573065001190 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 573065001191 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 573065001192 TadE-like protein; Region: TadE; pfam07811 573065001193 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 573065001194 TadE-like protein; Region: TadE; pfam07811 573065001195 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 573065001196 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 573065001197 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 573065001198 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 573065001199 C-terminal peptidase (prc); Region: prc; TIGR00225 573065001200 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 573065001201 protein binding site [polypeptide binding]; other site 573065001202 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 573065001203 Catalytic dyad [active] 573065001204 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573065001205 Peptidase family M23; Region: Peptidase_M23; pfam01551 573065001206 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 573065001207 dimer interface [polypeptide binding]; other site 573065001208 putative radical transfer pathway; other site 573065001209 diiron center [ion binding]; other site 573065001210 tyrosyl radical; other site 573065001211 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065001212 binding surface 573065001213 TPR motif; other site 573065001214 TPR repeat; Region: TPR_11; pfam13414 573065001215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065001216 binding surface 573065001217 TPR motif; other site 573065001218 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 573065001219 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 573065001220 interface (dimer of trimers) [polypeptide binding]; other site 573065001221 Substrate-binding/catalytic site; other site 573065001222 Zn-binding sites [ion binding]; other site 573065001223 Bacterial SH3 domain; Region: SH3_4; pfam06347 573065001224 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573065001225 NlpC/P60 family; Region: NLPC_P60; cl17555 573065001226 Cytochrome c2 [Energy production and conversion]; Region: COG3474 573065001227 prephenate dehydratase; Provisional; Region: PRK11899 573065001228 Prephenate dehydratase; Region: PDT; pfam00800 573065001229 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 573065001230 putative L-Phe binding site [chemical binding]; other site 573065001231 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 573065001232 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573065001233 catalytic residues [active] 573065001234 central insert; other site 573065001235 heme exporter protein CcmD; Region: cytochro_ccmD; TIGR03141 573065001236 heme exporter protein CcmC; Region: ccmC; TIGR01191 573065001237 CcmB protein; Region: CcmB; pfam03379 573065001238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065001239 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 573065001240 Walker A/P-loop; other site 573065001241 ATP binding site [chemical binding]; other site 573065001242 Q-loop/lid; other site 573065001243 ABC transporter signature motif; other site 573065001244 Walker B; other site 573065001245 D-loop; other site 573065001246 H-loop/switch region; other site 573065001247 aconitate hydratase; Validated; Region: PRK09277 573065001248 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 573065001249 substrate binding site [chemical binding]; other site 573065001250 ligand binding site [chemical binding]; other site 573065001251 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 573065001252 substrate binding site [chemical binding]; other site 573065001253 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 573065001254 GIY-YIG motif/motif A; other site 573065001255 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 573065001256 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 573065001257 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 573065001258 substrate binding site [chemical binding]; other site 573065001259 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 573065001260 substrate binding site [chemical binding]; other site 573065001261 ligand binding site [chemical binding]; other site 573065001262 TM2 domain; Region: TM2; pfam05154 573065001263 Short C-terminal domain; Region: SHOCT; pfam09851 573065001264 glucuronate isomerase; Reviewed; Region: PRK02925 573065001265 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 573065001266 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065001267 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065001268 DNA binding site [nucleotide binding] 573065001269 domain linker motif; other site 573065001270 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 573065001271 putative dimerization interface [polypeptide binding]; other site 573065001272 putative ligand binding site [chemical binding]; other site 573065001273 galactarate dehydratase; Region: galactar-dH20; TIGR03248 573065001274 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 573065001275 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 573065001276 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 573065001277 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 573065001278 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 573065001279 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065001280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065001281 non-specific DNA binding site [nucleotide binding]; other site 573065001282 salt bridge; other site 573065001283 sequence-specific DNA binding site [nucleotide binding]; other site 573065001284 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 573065001285 Domain of unknown function (DUF955); Region: DUF955; pfam06114 573065001286 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 573065001287 isocitrate lyase; Provisional; Region: PRK15063 573065001288 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 573065001289 tetramer interface [polypeptide binding]; other site 573065001290 active site 573065001291 Mg2+/Mn2+ binding site [ion binding]; other site 573065001292 Zinc-finger domain; Region: zf-CHCC; pfam10276 573065001293 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573065001294 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 573065001295 dimer interface [polypeptide binding]; other site 573065001296 active site 573065001297 metal binding site [ion binding]; metal-binding site 573065001298 glutathione binding site [chemical binding]; other site 573065001299 DNA polymerase I; Provisional; Region: PRK05755 573065001300 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 573065001301 active site 573065001302 metal binding site 1 [ion binding]; metal-binding site 573065001303 putative 5' ssDNA interaction site; other site 573065001304 metal binding site 3; metal-binding site 573065001305 metal binding site 2 [ion binding]; metal-binding site 573065001306 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 573065001307 putative DNA binding site [nucleotide binding]; other site 573065001308 putative metal binding site [ion binding]; other site 573065001309 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 573065001310 active site 573065001311 catalytic site [active] 573065001312 substrate binding site [chemical binding]; other site 573065001313 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 573065001314 active site 573065001315 DNA binding site [nucleotide binding] 573065001316 catalytic site [active] 573065001317 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573065001318 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 573065001319 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 573065001320 PA/protease or protease-like domain interface [polypeptide binding]; other site 573065001321 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 573065001322 metal binding site [ion binding]; metal-binding site 573065001323 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573065001324 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 573065001325 dimer interface [polypeptide binding]; other site 573065001326 putative metal binding site [ion binding]; other site 573065001327 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573065001328 HAMP domain; Region: HAMP; pfam00672 573065001329 dimerization interface [polypeptide binding]; other site 573065001330 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065001331 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065001332 dimer interface [polypeptide binding]; other site 573065001333 putative CheW interface [polypeptide binding]; other site 573065001334 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573065001335 HAMP domain; Region: HAMP; pfam00672 573065001336 dimerization interface [polypeptide binding]; other site 573065001337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065001338 dimer interface [polypeptide binding]; other site 573065001339 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065001340 putative CheW interface [polypeptide binding]; other site 573065001341 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573065001342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001343 active site 573065001344 phosphorylation site [posttranslational modification] 573065001345 intermolecular recognition site; other site 573065001346 dimerization interface [polypeptide binding]; other site 573065001347 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065001348 DNA binding site [nucleotide binding] 573065001349 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 573065001350 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 573065001351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065001352 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573065001353 dimerization interface [polypeptide binding]; other site 573065001354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065001355 dimer interface [polypeptide binding]; other site 573065001356 phosphorylation site [posttranslational modification] 573065001357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065001358 ATP binding site [chemical binding]; other site 573065001359 Mg2+ binding site [ion binding]; other site 573065001360 G-X-G motif; other site 573065001361 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 573065001362 Hpr binding site; other site 573065001363 active site 573065001364 homohexamer subunit interaction site [polypeptide binding]; other site 573065001365 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 573065001366 active pocket/dimerization site; other site 573065001367 active site 573065001368 phosphorylation site [posttranslational modification] 573065001369 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 573065001370 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 573065001371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573065001372 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 573065001373 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573065001374 DNA binding site [nucleotide binding] 573065001375 active site 573065001376 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 573065001377 active site 573065001378 DNA polymerase IV; Validated; Region: PRK02406 573065001379 DNA binding site [nucleotide binding] 573065001380 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 573065001381 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 573065001382 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 573065001383 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 573065001384 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 573065001385 NADP binding site [chemical binding]; other site 573065001386 dimer interface [polypeptide binding]; other site 573065001387 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 573065001388 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 573065001389 putative active site [active] 573065001390 putative dimer interface [polypeptide binding]; other site 573065001391 OsmC-like protein; Region: OsmC; cl00767 573065001392 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 573065001393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 573065001394 PAS domain; Region: PAS_5; pfam07310 573065001395 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573065001396 Sel1-like repeats; Region: SEL1; smart00671 573065001397 Sel1-like repeats; Region: SEL1; smart00671 573065001398 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573065001399 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 573065001400 Ribosomal protein S21e; Region: Ribosomal_S21e; pfam01249 573065001401 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 573065001402 DEAD/DEAH box helicase; Region: DEAD; pfam00270 573065001403 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 573065001404 2-isopropylmalate synthase; Validated; Region: PRK03739 573065001405 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 573065001406 active site 573065001407 catalytic residues [active] 573065001408 metal binding site [ion binding]; metal-binding site 573065001409 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 573065001410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 573065001411 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 573065001412 hypothetical protein; Provisional; Region: PRK06034 573065001413 Chorismate mutase type II; Region: CM_2; smart00830 573065001414 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 573065001415 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573065001416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065001417 homodimer interface [polypeptide binding]; other site 573065001418 catalytic residue [active] 573065001419 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 573065001420 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 573065001421 [2Fe-2S] cluster binding site [ion binding]; other site 573065001422 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 573065001423 hydrophobic ligand binding site; other site 573065001424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065001425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065001426 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 573065001427 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 573065001428 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 573065001429 Ligand binding site [chemical binding]; other site 573065001430 Electron transfer flavoprotein domain; Region: ETF; pfam01012 573065001431 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 573065001432 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 573065001433 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 573065001434 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 573065001435 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 573065001436 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 573065001437 Predicted membrane protein [Function unknown]; Region: COG2311 573065001438 Protein of unknown function (DUF418); Region: DUF418; cl12135 573065001439 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 573065001440 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573065001441 catalytic residues [active] 573065001442 argininosuccinate lyase; Provisional; Region: PRK00855 573065001443 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 573065001444 active sites [active] 573065001445 tetramer interface [polypeptide binding]; other site 573065001446 diaminopimelate decarboxylase; Region: lysA; TIGR01048 573065001447 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 573065001448 active site 573065001449 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573065001450 substrate binding site [chemical binding]; other site 573065001451 catalytic residues [active] 573065001452 dimer interface [polypeptide binding]; other site 573065001453 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 573065001454 active site 573065001455 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 573065001456 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573065001457 active site 573065001458 ATP binding site [chemical binding]; other site 573065001459 substrate binding site [chemical binding]; other site 573065001460 activation loop (A-loop); other site 573065001461 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065001462 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065001463 dimer interface [polypeptide binding]; other site 573065001464 putative CheW interface [polypeptide binding]; other site 573065001465 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 573065001466 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 573065001467 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 573065001468 trimer interface [polypeptide binding]; other site 573065001469 active site 573065001470 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 573065001471 trimer interface [polypeptide binding]; other site 573065001472 active site 573065001473 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 573065001474 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573065001475 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573065001476 active site 573065001477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573065001478 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 573065001479 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 573065001480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065001481 non-specific DNA binding site [nucleotide binding]; other site 573065001482 salt bridge; other site 573065001483 sequence-specific DNA binding site [nucleotide binding]; other site 573065001484 TraB family; Region: TraB; pfam01963 573065001485 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 573065001486 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573065001487 inhibitor-cofactor binding pocket; inhibition site 573065001488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065001489 catalytic residue [active] 573065001490 ornithine carbamoyltransferase; Provisional; Region: PRK00779 573065001491 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573065001492 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573065001493 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573065001494 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573065001495 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573065001496 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 573065001497 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 573065001498 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 573065001499 FOG: CBS domain [General function prediction only]; Region: COG0517 573065001500 Fic/DOC family; Region: Fic; cl00960 573065001501 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573065001502 Beta-lactamase; Region: Beta-lactamase; pfam00144 573065001503 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573065001504 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 573065001505 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573065001506 active site 573065001507 NTP binding site [chemical binding]; other site 573065001508 metal binding triad [ion binding]; metal-binding site 573065001509 antibiotic binding site [chemical binding]; other site 573065001510 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 573065001511 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 573065001512 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573065001513 Walker A motif; other site 573065001514 ATP binding site [chemical binding]; other site 573065001515 Walker B motif; other site 573065001516 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 573065001517 Phosphoesterase family; Region: Phosphoesterase; pfam04185 573065001518 Domain of unknown function (DUF756); Region: DUF756; pfam05506 573065001519 Domain of unknown function (DUF756); Region: DUF756; pfam05506 573065001520 PhoD-like phosphatase; Region: PhoD; pfam09423 573065001521 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 573065001522 putative active site [active] 573065001523 putative metal binding site [ion binding]; other site 573065001524 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 573065001525 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 573065001526 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065001527 N-terminal plug; other site 573065001528 ligand-binding site [chemical binding]; other site 573065001529 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573065001530 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573065001531 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573065001532 putative active site [active] 573065001533 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573065001534 MULE transposase domain; Region: MULE; pfam10551 573065001535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065001536 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573065001537 Walker A motif; other site 573065001538 ATP binding site [chemical binding]; other site 573065001539 Walker B motif; other site 573065001540 arginine finger; other site 573065001541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065001542 Walker A motif; other site 573065001543 ATP binding site [chemical binding]; other site 573065001544 Walker B motif; other site 573065001545 arginine finger; other site 573065001546 Transmembrane secretion effector; Region: MFS_3; pfam05977 573065001547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065001548 Predicted membrane protein [Function unknown]; Region: COG2259 573065001549 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 573065001550 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 573065001551 XapX domain; Region: XapX; TIGR03510 573065001552 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 573065001553 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 573065001554 active site 573065001555 Isochorismatase family; Region: Isochorismatase; pfam00857 573065001556 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 573065001557 catalytic triad [active] 573065001558 dimer interface [polypeptide binding]; other site 573065001559 conserved cis-peptide bond; other site 573065001560 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 573065001561 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 573065001562 tetramer interface [polypeptide binding]; other site 573065001563 heme binding pocket [chemical binding]; other site 573065001564 NADPH binding site [chemical binding]; other site 573065001565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 573065001566 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573065001567 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065001568 Response regulator receiver domain; Region: Response_reg; pfam00072 573065001569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001570 active site 573065001571 phosphorylation site [posttranslational modification] 573065001572 intermolecular recognition site; other site 573065001573 dimerization interface [polypeptide binding]; other site 573065001574 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 573065001575 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 573065001576 AAA ATPase domain; Region: AAA_16; pfam13191 573065001577 Predicted ATPase [General function prediction only]; Region: COG3899 573065001578 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573065001579 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573065001580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065001581 dimer interface [polypeptide binding]; other site 573065001582 phosphorylation site [posttranslational modification] 573065001583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065001584 ATP binding site [chemical binding]; other site 573065001585 Mg2+ binding site [ion binding]; other site 573065001586 G-X-G motif; other site 573065001587 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 573065001588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001589 active site 573065001590 phosphorylation site [posttranslational modification] 573065001591 intermolecular recognition site; other site 573065001592 dimerization interface [polypeptide binding]; other site 573065001593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573065001594 DNA binding residues [nucleotide binding] 573065001595 dimerization interface [polypeptide binding]; other site 573065001596 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573065001597 MULE transposase domain; Region: MULE; pfam10551 573065001598 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 573065001599 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573065001600 Beta-lactamase; Region: Beta-lactamase; pfam00144 573065001601 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065001602 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065001603 Predicted membrane protein [Function unknown]; Region: COG4709 573065001604 Predicted transcriptional regulators [Transcription]; Region: COG1695 573065001605 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573065001606 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 573065001607 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573065001608 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573065001609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065001610 binding surface 573065001611 TPR motif; other site 573065001612 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573065001613 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573065001614 CHAT domain; Region: CHAT; pfam12770 573065001615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573065001616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001617 active site 573065001618 phosphorylation site [posttranslational modification] 573065001619 intermolecular recognition site; other site 573065001620 dimerization interface [polypeptide binding]; other site 573065001621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065001622 DNA binding site [nucleotide binding] 573065001623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065001624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065001625 ATP binding site [chemical binding]; other site 573065001626 Mg2+ binding site [ion binding]; other site 573065001627 G-X-G motif; other site 573065001628 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 573065001629 RelB antitoxin; Region: RelB; cl01171 573065001630 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 573065001631 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573065001632 active site 573065001633 HIGH motif; other site 573065001634 nucleotide binding site [chemical binding]; other site 573065001635 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 573065001636 active site 573065001637 KMSKS motif; other site 573065001638 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 573065001639 putative ADP-binding pocket [chemical binding]; other site 573065001640 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065001641 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573065001642 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065001643 putative DNA binding site [nucleotide binding]; other site 573065001644 putative Zn2+ binding site [ion binding]; other site 573065001645 AsnC family; Region: AsnC_trans_reg; pfam01037 573065001646 Predicted transcriptional regulators [Transcription]; Region: COG1733 573065001647 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 573065001648 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 573065001649 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 573065001650 Ligand Binding Site [chemical binding]; other site 573065001651 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 573065001652 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573065001653 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 573065001654 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573065001655 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573065001656 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 573065001657 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 573065001658 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573065001659 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 573065001660 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573065001661 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 573065001662 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 573065001663 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 573065001664 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 573065001665 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 573065001666 FliG C-terminal domain; Region: FliG_C; pfam01706 573065001667 flagellar assembly protein H; Validated; Region: fliH; PRK06032 573065001668 flagellar motor switch protein; Reviewed; Region: PRK08916 573065001669 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573065001670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065001671 Walker A motif; other site 573065001672 ATP binding site [chemical binding]; other site 573065001673 Walker B motif; other site 573065001674 arginine finger; other site 573065001675 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573065001676 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 573065001677 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 573065001678 FHIPEP family; Region: FHIPEP; pfam00771 573065001679 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 573065001680 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 573065001681 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 573065001682 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 573065001683 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 573065001684 Walker A motif/ATP binding site; other site 573065001685 Walker B motif; other site 573065001686 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 573065001687 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 573065001688 active site 573065001689 catalytic triad [active] 573065001690 oxyanion hole [active] 573065001691 Autotransporter beta-domain; Region: Autotransporter; smart00869 573065001692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573065001693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001694 active site 573065001695 phosphorylation site [posttranslational modification] 573065001696 intermolecular recognition site; other site 573065001697 dimerization interface [polypeptide binding]; other site 573065001698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065001699 DNA binding site [nucleotide binding] 573065001700 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 573065001701 Low molecular weight phosphatase family; Region: LMWPc; cl00105 573065001702 active site 573065001703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065001704 dimerization interface [polypeptide binding]; other site 573065001705 putative DNA binding site [nucleotide binding]; other site 573065001706 putative Zn2+ binding site [ion binding]; other site 573065001707 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573065001708 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573065001709 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573065001710 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 573065001711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001712 active site 573065001713 phosphorylation site [posttranslational modification] 573065001714 intermolecular recognition site; other site 573065001715 dimerization interface [polypeptide binding]; other site 573065001716 CheB methylesterase; Region: CheB_methylest; pfam01339 573065001717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001718 Response regulator receiver domain; Region: Response_reg; pfam00072 573065001719 active site 573065001720 phosphorylation site [posttranslational modification] 573065001721 intermolecular recognition site; other site 573065001722 dimerization interface [polypeptide binding]; other site 573065001723 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573065001724 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573065001725 putative binding surface; other site 573065001726 active site 573065001727 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573065001728 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573065001729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065001730 ATP binding site [chemical binding]; other site 573065001731 Mg2+ binding site [ion binding]; other site 573065001732 G-X-G motif; other site 573065001733 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 573065001734 CheW-like domain; Region: CheW; pfam01584 573065001735 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 573065001736 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 573065001737 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573065001738 dimer interface [polypeptide binding]; other site 573065001739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065001740 catalytic residue [active] 573065001741 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 573065001742 PAS domain; Region: PAS_5; pfam07310 573065001743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 573065001744 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 573065001745 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 573065001746 DnaA box-binding interface [nucleotide binding]; other site 573065001747 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 573065001748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065001749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065001750 dimer interface [polypeptide binding]; other site 573065001751 phosphorylation site [posttranslational modification] 573065001752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065001753 ATP binding site [chemical binding]; other site 573065001754 Mg2+ binding site [ion binding]; other site 573065001755 G-X-G motif; other site 573065001756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065001757 dimer interface [polypeptide binding]; other site 573065001758 phosphorylation site [posttranslational modification] 573065001759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065001760 ATP binding site [chemical binding]; other site 573065001761 Mg2+ binding site [ion binding]; other site 573065001762 G-X-G motif; other site 573065001763 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 573065001764 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 573065001765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065001766 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 573065001767 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 573065001768 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 573065001769 G1 box; other site 573065001770 putative GEF interaction site [polypeptide binding]; other site 573065001771 GTP/Mg2+ binding site [chemical binding]; other site 573065001772 Switch I region; other site 573065001773 G2 box; other site 573065001774 G3 box; other site 573065001775 Switch II region; other site 573065001776 G4 box; other site 573065001777 G5 box; other site 573065001778 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 573065001779 Response regulator receiver domain; Region: Response_reg; pfam00072 573065001780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001781 active site 573065001782 phosphorylation site [posttranslational modification] 573065001783 intermolecular recognition site; other site 573065001784 dimerization interface [polypeptide binding]; other site 573065001785 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 573065001786 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 573065001787 substrate binding site [chemical binding]; other site 573065001788 methionine synthase; Provisional; Region: PRK01207 573065001789 THF binding site; other site 573065001790 zinc-binding site [ion binding]; other site 573065001791 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 573065001792 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 573065001793 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 573065001794 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 573065001795 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 573065001796 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 573065001797 GTP binding site; other site 573065001798 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573065001799 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 573065001800 active site 573065001801 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 573065001802 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573065001803 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 573065001804 inhibitor binding site; inhibition site 573065001805 active site 573065001806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065001807 D-galactonate transporter; Region: 2A0114; TIGR00893 573065001808 putative substrate translocation pore; other site 573065001809 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573065001810 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 573065001811 inhibitor binding site; inhibition site 573065001812 active site 573065001813 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573065001814 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065001815 LytTr DNA-binding domain; Region: LytTR; pfam04397 573065001816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065001817 dimerization interface [polypeptide binding]; other site 573065001818 putative DNA binding site [nucleotide binding]; other site 573065001819 putative Zn2+ binding site [ion binding]; other site 573065001820 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573065001821 Protein export membrane protein; Region: SecD_SecF; cl14618 573065001822 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573065001823 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573065001824 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065001825 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573065001826 active site residue [active] 573065001827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 573065001828 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 573065001829 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 573065001830 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 573065001831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001832 active site 573065001833 phosphorylation site [posttranslational modification] 573065001834 intermolecular recognition site; other site 573065001835 dimerization interface [polypeptide binding]; other site 573065001836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065001837 DNA binding site [nucleotide binding] 573065001838 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 573065001839 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 573065001840 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 573065001841 Ligand Binding Site [chemical binding]; other site 573065001842 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 573065001843 GAF domain; Region: GAF_3; pfam13492 573065001844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065001845 dimer interface [polypeptide binding]; other site 573065001846 phosphorylation site [posttranslational modification] 573065001847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065001848 ATP binding site [chemical binding]; other site 573065001849 Mg2+ binding site [ion binding]; other site 573065001850 G-X-G motif; other site 573065001851 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 573065001852 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 573065001853 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573065001854 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573065001855 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 573065001856 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 573065001857 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 573065001858 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 573065001859 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573065001860 FMN binding site [chemical binding]; other site 573065001861 active site 573065001862 catalytic residues [active] 573065001863 substrate binding site [chemical binding]; other site 573065001864 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 573065001865 catalytic motif [active] 573065001866 Catalytic residue [active] 573065001867 HAMP domain; Region: HAMP; pfam00672 573065001868 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065001869 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065001870 dimer interface [polypeptide binding]; other site 573065001871 putative CheW interface [polypeptide binding]; other site 573065001872 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 573065001873 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 573065001874 excinuclease ABC subunit B; Provisional; Region: PRK05298 573065001875 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573065001876 ATP binding site [chemical binding]; other site 573065001877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573065001878 nucleotide binding region [chemical binding]; other site 573065001879 ATP-binding site [chemical binding]; other site 573065001880 Ultra-violet resistance protein B; Region: UvrB; pfam12344 573065001881 UvrB/uvrC motif; Region: UVR; pfam02151 573065001882 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 573065001883 Predicted membrane protein [Function unknown]; Region: COG3671 573065001884 DinB family; Region: DinB; cl17821 573065001885 DinB superfamily; Region: DinB_2; pfam12867 573065001886 Dihydroneopterin aldolase; Region: FolB; pfam02152 573065001887 active site 573065001888 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 573065001889 active site 573065001890 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 573065001891 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 573065001892 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 573065001893 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 573065001894 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 573065001895 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573065001896 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 573065001897 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 573065001898 putative hydrophobic ligand binding site [chemical binding]; other site 573065001899 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 573065001900 putative hydrophobic ligand binding site [chemical binding]; other site 573065001901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065001902 dimerization interface [polypeptide binding]; other site 573065001903 putative DNA binding site [nucleotide binding]; other site 573065001904 putative Zn2+ binding site [ion binding]; other site 573065001905 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 573065001906 aromatic arch; other site 573065001907 DCoH dimer interaction site [polypeptide binding]; other site 573065001908 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 573065001909 DCoH tetramer interaction site [polypeptide binding]; other site 573065001910 substrate binding site [chemical binding]; other site 573065001911 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 573065001912 cofactor binding site; other site 573065001913 metal binding site [ion binding]; metal-binding site 573065001914 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573065001915 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 573065001916 PA/protease or protease-like domain interface [polypeptide binding]; other site 573065001917 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 573065001918 Peptidase family M28; Region: Peptidase_M28; pfam04389 573065001919 metal binding site [ion binding]; metal-binding site 573065001920 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 573065001921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065001922 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573065001923 active site 573065001924 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 573065001925 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 573065001926 active site 573065001927 DNA binding site [nucleotide binding] 573065001928 Int/Topo IB signature motif; other site 573065001929 catalytic residues [active] 573065001930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001931 active site 573065001932 phosphorylation site [posttranslational modification] 573065001933 intermolecular recognition site; other site 573065001934 dimerization interface [polypeptide binding]; other site 573065001935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065001936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065001937 dimer interface [polypeptide binding]; other site 573065001938 phosphorylation site [posttranslational modification] 573065001939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065001940 ATP binding site [chemical binding]; other site 573065001941 Mg2+ binding site [ion binding]; other site 573065001942 G-X-G motif; other site 573065001943 Response regulator receiver domain; Region: Response_reg; pfam00072 573065001944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001945 active site 573065001946 phosphorylation site [posttranslational modification] 573065001947 intermolecular recognition site; other site 573065001948 dimerization interface [polypeptide binding]; other site 573065001949 CheB methylesterase; Region: CheB_methylest; pfam01339 573065001950 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573065001951 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573065001952 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573065001953 CHASE3 domain; Region: CHASE3; pfam05227 573065001954 GAF domain; Region: GAF_3; pfam13492 573065001955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065001956 dimer interface [polypeptide binding]; other site 573065001957 phosphorylation site [posttranslational modification] 573065001958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065001959 ATP binding site [chemical binding]; other site 573065001960 Mg2+ binding site [ion binding]; other site 573065001961 G-X-G motif; other site 573065001962 Response regulator receiver domain; Region: Response_reg; pfam00072 573065001963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001964 active site 573065001965 phosphorylation site [posttranslational modification] 573065001966 intermolecular recognition site; other site 573065001967 dimerization interface [polypeptide binding]; other site 573065001968 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573065001969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001970 active site 573065001971 phosphorylation site [posttranslational modification] 573065001972 intermolecular recognition site; other site 573065001973 dimerization interface [polypeptide binding]; other site 573065001974 Response regulator receiver domain; Region: Response_reg; pfam00072 573065001975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001976 active site 573065001977 phosphorylation site [posttranslational modification] 573065001978 intermolecular recognition site; other site 573065001979 dimerization interface [polypeptide binding]; other site 573065001980 Response regulator receiver domain; Region: Response_reg; pfam00072 573065001981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065001982 active site 573065001983 phosphorylation site [posttranslational modification] 573065001984 intermolecular recognition site; other site 573065001985 dimerization interface [polypeptide binding]; other site 573065001986 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 573065001987 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573065001988 active site 573065001989 HIGH motif; other site 573065001990 nucleotide binding site [chemical binding]; other site 573065001991 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573065001992 KMSKS motif; other site 573065001993 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573065001994 tRNA binding surface [nucleotide binding]; other site 573065001995 anticodon binding site; other site 573065001996 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 573065001997 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 573065001998 catalytic residue [active] 573065001999 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 573065002000 catalytic residues [active] 573065002001 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573065002002 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573065002003 peroxiredoxin; Region: AhpC; TIGR03137 573065002004 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 573065002005 dimer interface [polypeptide binding]; other site 573065002006 decamer (pentamer of dimers) interface [polypeptide binding]; other site 573065002007 catalytic triad [active] 573065002008 peroxidatic and resolving cysteines [active] 573065002009 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065002010 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065002011 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065002012 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065002013 SapC; Region: SapC; pfam07277 573065002014 Cupin-like domain; Region: Cupin_8; pfam13621 573065002015 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065002016 YGGT family; Region: YGGT; pfam02325 573065002017 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 573065002018 tartrate dehydrogenase; Region: TTC; TIGR02089 573065002019 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 573065002020 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 573065002021 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 573065002022 substrate binding site [chemical binding]; other site 573065002023 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 573065002024 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 573065002025 substrate binding site [chemical binding]; other site 573065002026 ligand binding site [chemical binding]; other site 573065002027 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 573065002028 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 573065002029 homodimer interface [polypeptide binding]; other site 573065002030 substrate-cofactor binding pocket; other site 573065002031 catalytic residue [active] 573065002032 2-isopropylmalate synthase; Validated; Region: PRK00915 573065002033 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 573065002034 active site 573065002035 catalytic residues [active] 573065002036 metal binding site [ion binding]; metal-binding site 573065002037 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 573065002038 ACT domain; Region: ACT_5; pfam13710 573065002039 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 573065002040 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573065002041 PYR/PP interface [polypeptide binding]; other site 573065002042 dimer interface [polypeptide binding]; other site 573065002043 TPP binding site [chemical binding]; other site 573065002044 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573065002045 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 573065002046 TPP-binding site [chemical binding]; other site 573065002047 dimer interface [polypeptide binding]; other site 573065002048 ketol-acid reductoisomerase; Provisional; Region: PRK05479 573065002049 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 573065002050 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 573065002051 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 573065002052 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 573065002053 Sel1-like repeats; Region: SEL1; smart00671 573065002054 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573065002055 Sel1-like repeats; Region: SEL1; smart00671 573065002056 Sel1-like repeats; Region: SEL1; smart00671 573065002057 Sel1-like repeats; Region: SEL1; smart00671 573065002058 Sel1-like repeats; Region: SEL1; smart00671 573065002059 Sel1-like repeats; Region: SEL1; smart00671 573065002060 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 573065002061 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 573065002062 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 573065002063 catalytic residues [active] 573065002064 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 573065002065 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 573065002066 Na binding site [ion binding]; other site 573065002067 Protein of unknown function, DUF485; Region: DUF485; pfam04341 573065002068 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160 573065002069 active site 573065002070 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 573065002071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065002072 FeS/SAM binding site; other site 573065002073 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 573065002074 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 573065002075 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 573065002076 metal ion-dependent adhesion site (MIDAS); other site 573065002077 MoxR-like ATPases [General function prediction only]; Region: COG0714 573065002078 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 573065002079 SWIM zinc finger; Region: SWIM; pfam04434 573065002080 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 573065002081 diiron binding motif [ion binding]; other site 573065002082 RF-1 domain; Region: RF-1; cl17422 573065002083 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 573065002084 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 573065002085 hypothetical protein; Reviewed; Region: PRK09588 573065002086 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573065002087 active site 573065002088 NTP binding site [chemical binding]; other site 573065002089 metal binding triad [ion binding]; metal-binding site 573065002090 antibiotic binding site [chemical binding]; other site 573065002091 HEPN domain; Region: HEPN; cl00824 573065002092 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573065002093 Resolvase, N terminal domain; Region: Resolvase; pfam00239 573065002094 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 573065002095 DNA-binding interface [nucleotide binding]; DNA binding site 573065002096 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 573065002097 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 573065002098 HemY protein N-terminus; Region: HemY_N; pfam07219 573065002099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 573065002100 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 573065002101 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 573065002102 active site 573065002103 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 573065002104 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 573065002105 domain interfaces; other site 573065002106 active site 573065002107 UGMP family protein; Validated; Region: PRK09604 573065002108 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 573065002109 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 573065002110 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 573065002111 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 573065002112 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 573065002113 iron-sulfur cluster [ion binding]; other site 573065002114 [2Fe-2S] cluster binding site [ion binding]; other site 573065002115 Creatinine amidohydrolase; Region: Creatininase; pfam02633 573065002116 acetyl-CoA synthetase; Provisional; Region: PRK00174 573065002117 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 573065002118 active site 573065002119 CoA binding site [chemical binding]; other site 573065002120 acyl-activating enzyme (AAE) consensus motif; other site 573065002121 AMP binding site [chemical binding]; other site 573065002122 acetate binding site [chemical binding]; other site 573065002123 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573065002124 endonuclease III; Region: ENDO3c; smart00478 573065002125 minor groove reading motif; other site 573065002126 helix-hairpin-helix signature motif; other site 573065002127 substrate binding pocket [chemical binding]; other site 573065002128 active site 573065002129 Predicted membrane protein [Function unknown]; Region: COG3766 573065002130 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 573065002131 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 573065002132 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065002133 FeS/SAM binding site; other site 573065002134 Cytochrome c; Region: Cytochrom_C; cl11414 573065002135 MAPEG family; Region: MAPEG; cl09190 573065002136 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 573065002137 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 573065002138 ATP binding site [chemical binding]; other site 573065002139 substrate interface [chemical binding]; other site 573065002140 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 573065002141 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 573065002142 active site 573065002143 HslU subunit interaction site [polypeptide binding]; other site 573065002144 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 573065002145 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 573065002146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573065002147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 573065002148 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 573065002149 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573065002150 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 573065002151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065002152 Walker A motif; other site 573065002153 ATP binding site [chemical binding]; other site 573065002154 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 573065002155 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573065002156 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 573065002157 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 573065002158 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 573065002159 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 573065002160 Low molecular weight phosphatase family; Region: LMWPc; cd00115 573065002161 active site 573065002162 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 573065002163 metal binding site [ion binding]; metal-binding site 573065002164 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 573065002165 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573065002166 minor groove reading motif; other site 573065002167 helix-hairpin-helix signature motif; other site 573065002168 substrate binding pocket [chemical binding]; other site 573065002169 active site 573065002170 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 573065002171 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573065002172 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 573065002173 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573065002174 substrate binding site [chemical binding]; other site 573065002175 ATP binding site [chemical binding]; other site 573065002176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 573065002177 Smr domain; Region: Smr; pfam01713 573065002178 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 573065002179 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 573065002180 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573065002181 PAS domain; Region: PAS; smart00091 573065002182 PAS domain; Region: PAS_9; pfam13426 573065002183 putative active site [active] 573065002184 heme pocket [chemical binding]; other site 573065002185 PAS domain; Region: PAS_9; pfam13426 573065002186 PAS fold; Region: PAS_3; pfam08447 573065002187 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 573065002188 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 573065002189 dimerization interface [polypeptide binding]; other site 573065002190 ligand binding site [chemical binding]; other site 573065002191 NADP binding site [chemical binding]; other site 573065002192 catalytic site [active] 573065002193 Bacterial SH3 domain; Region: SH3_4; pfam06347 573065002194 Bacterial SH3 domain; Region: SH3_4; pfam06347 573065002195 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 573065002196 active site 1 [active] 573065002197 dimer interface [polypeptide binding]; other site 573065002198 active site 2 [active] 573065002199 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 573065002200 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 573065002201 dimer interface [polypeptide binding]; other site 573065002202 active site 573065002203 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 573065002204 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 573065002205 NAD binding site [chemical binding]; other site 573065002206 homotetramer interface [polypeptide binding]; other site 573065002207 homodimer interface [polypeptide binding]; other site 573065002208 substrate binding site [chemical binding]; other site 573065002209 active site 573065002210 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 573065002211 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573065002212 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 573065002213 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 573065002214 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 573065002215 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 573065002216 putative C-terminal domain interface [polypeptide binding]; other site 573065002217 putative GSH binding site (G-site) [chemical binding]; other site 573065002218 putative dimer interface [polypeptide binding]; other site 573065002219 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 573065002220 putative substrate binding pocket (H-site) [chemical binding]; other site 573065002221 putative N-terminal domain interface [polypeptide binding]; other site 573065002222 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 573065002223 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 573065002224 putative active site [active] 573065002225 metal binding site [ion binding]; metal-binding site 573065002226 Uncharacterized conserved protein [Function unknown]; Region: COG2353 573065002227 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065002228 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065002229 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065002230 PhoD-like phosphatase; Region: PhoD; pfam09423 573065002231 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 573065002232 putative active site [active] 573065002233 putative metal binding site [ion binding]; other site 573065002234 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 573065002235 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 573065002236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065002237 binding surface 573065002238 TPR motif; other site 573065002239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065002240 NAD(P) binding site [chemical binding]; other site 573065002241 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 573065002242 Protein of unknown function, DUF393; Region: DUF393; pfam04134 573065002243 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 573065002244 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 573065002245 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 573065002246 C-terminal domain interface [polypeptide binding]; other site 573065002247 GSH binding site (G-site) [chemical binding]; other site 573065002248 dimer interface [polypeptide binding]; other site 573065002249 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 573065002250 N-terminal domain interface [polypeptide binding]; other site 573065002251 putative dimer interface [polypeptide binding]; other site 573065002252 active site 573065002253 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 573065002254 putative deacylase active site [active] 573065002255 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 573065002256 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 573065002257 tetramer interface [polypeptide binding]; other site 573065002258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065002259 catalytic residue [active] 573065002260 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 573065002261 active site 2 [active] 573065002262 active site 1 [active] 573065002263 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 573065002264 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 573065002265 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 573065002266 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 573065002267 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 573065002268 FOG: CBS domain [General function prediction only]; Region: COG0517 573065002269 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 573065002270 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 573065002271 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 573065002272 active site 573065002273 Protein of unknown function (DUF805); Region: DUF805; pfam05656 573065002274 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 573065002275 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 573065002276 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 573065002277 metal binding site [ion binding]; metal-binding site 573065002278 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 573065002279 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 573065002280 substrate binding site [chemical binding]; other site 573065002281 glutamase interaction surface [polypeptide binding]; other site 573065002282 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 573065002283 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 573065002284 catalytic residues [active] 573065002285 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 573065002286 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 573065002287 putative active site [active] 573065002288 oxyanion strand; other site 573065002289 catalytic triad [active] 573065002290 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573065002291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573065002292 catalytic residue [active] 573065002293 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 573065002294 putative active site pocket [active] 573065002295 4-fold oligomerization interface [polypeptide binding]; other site 573065002296 metal binding residues [ion binding]; metal-binding site 573065002297 3-fold/trimer interface [polypeptide binding]; other site 573065002298 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 573065002299 histidinol dehydrogenase; Region: hisD; TIGR00069 573065002300 NAD binding site [chemical binding]; other site 573065002301 dimerization interface [polypeptide binding]; other site 573065002302 product binding site; other site 573065002303 substrate binding site [chemical binding]; other site 573065002304 zinc binding site [ion binding]; other site 573065002305 catalytic residues [active] 573065002306 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 573065002307 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 573065002308 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 573065002309 Trp repressor protein; Region: Trp_repressor; cl17266 573065002310 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 573065002311 putative chaperone; Provisional; Region: PRK11678 573065002312 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 573065002313 nucleotide binding site [chemical binding]; other site 573065002314 putative NEF/HSP70 interaction site [polypeptide binding]; other site 573065002315 SBD interface [polypeptide binding]; other site 573065002316 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 573065002317 Phosphoesterase family; Region: Phosphoesterase; pfam04185 573065002318 Domain of unknown function (DUF756); Region: DUF756; pfam05506 573065002319 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 573065002320 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573065002321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065002322 dimer interface [polypeptide binding]; other site 573065002323 conserved gate region; other site 573065002324 putative PBP binding loops; other site 573065002325 ABC-ATPase subunit interface; other site 573065002326 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573065002327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065002328 dimer interface [polypeptide binding]; other site 573065002329 conserved gate region; other site 573065002330 putative PBP binding loops; other site 573065002331 ABC-ATPase subunit interface; other site 573065002332 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 573065002333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065002334 Walker A/P-loop; other site 573065002335 ATP binding site [chemical binding]; other site 573065002336 Q-loop/lid; other site 573065002337 ABC transporter signature motif; other site 573065002338 Walker B; other site 573065002339 D-loop; other site 573065002340 H-loop/switch region; other site 573065002341 TOBE domain; Region: TOBE_2; pfam08402 573065002342 fumarate hydratase; Reviewed; Region: fumC; PRK00485 573065002343 Class II fumarases; Region: Fumarase_classII; cd01362 573065002344 active site 573065002345 tetramer interface [polypeptide binding]; other site 573065002346 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 573065002347 MAPEG family; Region: MAPEG; cl09190 573065002348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065002349 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 573065002350 Walker A/P-loop; other site 573065002351 ATP binding site [chemical binding]; other site 573065002352 Q-loop/lid; other site 573065002353 ABC transporter signature motif; other site 573065002354 Walker B; other site 573065002355 D-loop; other site 573065002356 H-loop/switch region; other site 573065002357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 573065002358 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 573065002359 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 573065002360 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 573065002361 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573065002362 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 573065002363 Ligand binding site; other site 573065002364 Putative Catalytic site; other site 573065002365 DXD motif; other site 573065002366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 573065002367 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 573065002368 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 573065002369 putative acyltransferase; Provisional; Region: PRK05790 573065002370 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 573065002371 dimer interface [polypeptide binding]; other site 573065002372 active site 573065002373 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 573065002374 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 573065002375 NAD(P) binding site [chemical binding]; other site 573065002376 homotetramer interface [polypeptide binding]; other site 573065002377 homodimer interface [polypeptide binding]; other site 573065002378 active site 573065002379 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 573065002380 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573065002381 Methyltransferase domain; Region: Methyltransf_11; pfam08241 573065002382 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573065002383 catalytic core [active] 573065002384 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 573065002385 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 573065002386 quinone interaction residues [chemical binding]; other site 573065002387 active site 573065002388 catalytic residues [active] 573065002389 FMN binding site [chemical binding]; other site 573065002390 substrate binding site [chemical binding]; other site 573065002391 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 573065002392 O-Antigen ligase; Region: Wzy_C; pfam04932 573065002393 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 573065002394 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 573065002395 SAF-like; Region: SAF_2; pfam13144 573065002396 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 573065002397 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 573065002398 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573065002399 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573065002400 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 573065002401 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573065002402 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 573065002403 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 573065002404 FtsX-like permease family; Region: FtsX; pfam02687 573065002405 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573065002406 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573065002407 Walker A/P-loop; other site 573065002408 ATP binding site [chemical binding]; other site 573065002409 Q-loop/lid; other site 573065002410 ABC transporter signature motif; other site 573065002411 Walker B; other site 573065002412 D-loop; other site 573065002413 H-loop/switch region; other site 573065002414 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 573065002415 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573065002416 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065002417 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573065002418 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 573065002419 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 573065002420 dimerization interface [polypeptide binding]; other site 573065002421 active site 573065002422 L-aspartate oxidase; Provisional; Region: PRK07512 573065002423 L-aspartate oxidase; Provisional; Region: PRK06175 573065002424 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573065002425 quinolinate synthetase; Provisional; Region: PRK09375 573065002426 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 573065002427 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 573065002428 dimerization interface [polypeptide binding]; other site 573065002429 DPS ferroxidase diiron center [ion binding]; other site 573065002430 ion pore; other site 573065002431 hypothetical protein; Provisional; Region: PRK09256 573065002432 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 573065002433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065002434 Coenzyme A binding pocket [chemical binding]; other site 573065002435 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 573065002436 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 573065002437 Mg++ binding site [ion binding]; other site 573065002438 putative catalytic motif [active] 573065002439 aspartate aminotransferase; Provisional; Region: PRK05764 573065002440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573065002441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065002442 homodimer interface [polypeptide binding]; other site 573065002443 catalytic residue [active] 573065002444 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 573065002445 putative catalytic site [active] 573065002446 putative metal binding site [ion binding]; other site 573065002447 putative phosphate binding site [ion binding]; other site 573065002448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065002449 active site 573065002450 phosphorylation site [posttranslational modification] 573065002451 intermolecular recognition site; other site 573065002452 dimerization interface [polypeptide binding]; other site 573065002453 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 573065002454 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 573065002455 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 573065002456 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065002457 N-terminal plug; other site 573065002458 ligand-binding site [chemical binding]; other site 573065002459 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 573065002460 TonB C terminal; Region: TonB_2; pfam13103 573065002461 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 573065002462 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573065002463 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573065002464 ligand binding site [chemical binding]; other site 573065002465 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 573065002466 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 573065002467 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065002468 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065002469 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 573065002470 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 573065002471 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 573065002472 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 573065002473 putative active site; other site 573065002474 catalytic triad [active] 573065002475 putative dimer interface [polypeptide binding]; other site 573065002476 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 573065002477 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573065002478 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 573065002479 active site 573065002480 HAMP domain; Region: HAMP; pfam00672 573065002481 dimerization interface [polypeptide binding]; other site 573065002482 PAS fold; Region: PAS; pfam00989 573065002483 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065002484 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065002485 dimer interface [polypeptide binding]; other site 573065002486 putative CheW interface [polypeptide binding]; other site 573065002487 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 573065002488 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 573065002489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065002490 Walker A motif; other site 573065002491 ATP binding site [chemical binding]; other site 573065002492 Walker B motif; other site 573065002493 arginine finger; other site 573065002494 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 573065002495 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 573065002496 hypothetical protein; Provisional; Region: PRK14625 573065002497 recombination protein RecR; Reviewed; Region: recR; PRK00076 573065002498 RecR protein; Region: RecR; pfam02132 573065002499 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 573065002500 putative active site [active] 573065002501 putative metal-binding site [ion binding]; other site 573065002502 tetramer interface [polypeptide binding]; other site 573065002503 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 573065002504 RmuC family; Region: RmuC; pfam02646 573065002505 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 573065002506 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 573065002507 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 573065002508 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573065002509 active site 573065002510 catalytic residues [active] 573065002511 metal binding site [ion binding]; metal-binding site 573065002512 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 573065002513 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 573065002514 putative active site [active] 573065002515 substrate binding site [chemical binding]; other site 573065002516 putative cosubstrate binding site; other site 573065002517 catalytic site [active] 573065002518 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 573065002519 substrate binding site [chemical binding]; other site 573065002520 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 573065002521 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 573065002522 dimerization interface 3.5A [polypeptide binding]; other site 573065002523 active site 573065002524 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 573065002525 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 573065002526 metal binding site [ion binding]; metal-binding site 573065002527 dimer interface [polypeptide binding]; other site 573065002528 H+ Antiporter protein; Region: 2A0121; TIGR00900 573065002529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065002530 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573065002531 Peptidase family M23; Region: Peptidase_M23; pfam01551 573065002532 Dicarboxylate transport; Region: DctA-YdbH; cl14674 573065002533 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 573065002534 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 573065002535 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573065002536 CHAP domain; Region: CHAP; pfam05257 573065002537 Surface antigen [General function prediction only]; Region: COG3942 573065002538 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 573065002539 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 573065002540 Cl binding site [ion binding]; other site 573065002541 oligomer interface [polypeptide binding]; other site 573065002542 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573065002543 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065002544 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065002545 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 573065002546 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065002547 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065002548 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065002549 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065002550 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 573065002551 metal binding site 2 [ion binding]; metal-binding site 573065002552 putative DNA binding helix; other site 573065002553 metal binding site 1 [ion binding]; metal-binding site 573065002554 dimer interface [polypeptide binding]; other site 573065002555 structural Zn2+ binding site [ion binding]; other site 573065002556 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065002557 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065002558 N-terminal plug; other site 573065002559 ligand-binding site [chemical binding]; other site 573065002560 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573065002561 MULE transposase domain; Region: MULE; pfam10551 573065002562 SapC; Region: SapC; pfam07277 573065002563 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 573065002564 active site 2 [active] 573065002565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065002566 non-specific DNA binding site [nucleotide binding]; other site 573065002567 salt bridge; other site 573065002568 sequence-specific DNA binding site [nucleotide binding]; other site 573065002569 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 573065002570 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 573065002571 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573065002572 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573065002573 CHASE4 domain; Region: CHASE4; cl01308 573065002574 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573065002575 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573065002576 metal binding site [ion binding]; metal-binding site 573065002577 active site 573065002578 I-site; other site 573065002579 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573065002580 putative glutathione S-transferase; Provisional; Region: PRK10357 573065002581 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573065002582 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 573065002583 dimer interface [polypeptide binding]; other site 573065002584 N-terminal domain interface [polypeptide binding]; other site 573065002585 putative substrate binding pocket (H-site) [chemical binding]; other site 573065002586 peptide chain release factor 1; Validated; Region: prfA; PRK00591 573065002587 This domain is found in peptide chain release factors; Region: PCRF; smart00937 573065002588 RF-1 domain; Region: RF-1; pfam00472 573065002589 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 573065002590 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 573065002591 MOSC domain; Region: MOSC; pfam03473 573065002592 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573065002593 catalytic core [active] 573065002594 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573065002595 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 573065002596 catalytic motif [active] 573065002597 Zn binding site [ion binding]; other site 573065002598 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065002599 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 573065002600 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065002601 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065002602 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065002603 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065002604 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 573065002605 catalytic nucleophile [active] 573065002606 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 573065002607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065002608 Walker A/P-loop; other site 573065002609 ATP binding site [chemical binding]; other site 573065002610 Q-loop/lid; other site 573065002611 ABC transporter signature motif; other site 573065002612 Walker B; other site 573065002613 D-loop; other site 573065002614 H-loop/switch region; other site 573065002615 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573065002616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065002617 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 573065002618 Walker A/P-loop; other site 573065002619 ATP binding site [chemical binding]; other site 573065002620 Q-loop/lid; other site 573065002621 ABC transporter signature motif; other site 573065002622 Walker B; other site 573065002623 D-loop; other site 573065002624 H-loop/switch region; other site 573065002625 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 573065002626 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 573065002627 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 573065002628 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 573065002629 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 573065002630 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 573065002631 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 573065002632 NAD(P) binding site [chemical binding]; other site 573065002633 homodimer interface [polypeptide binding]; other site 573065002634 substrate binding site [chemical binding]; other site 573065002635 active site 573065002636 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 573065002637 MoaE interaction surface [polypeptide binding]; other site 573065002638 MoeB interaction surface [polypeptide binding]; other site 573065002639 thiocarboxylated glycine; other site 573065002640 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 573065002641 MoaE homodimer interface [polypeptide binding]; other site 573065002642 MoaD interaction [polypeptide binding]; other site 573065002643 active site residues [active] 573065002644 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 573065002645 trimer interface [polypeptide binding]; other site 573065002646 dimer interface [polypeptide binding]; other site 573065002647 putative active site [active] 573065002648 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 573065002649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065002650 S-adenosylmethionine binding site [chemical binding]; other site 573065002651 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 573065002652 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 573065002653 catalytic triad [active] 573065002654 putative aminotransferase; Validated; Region: PRK07480 573065002655 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573065002656 inhibitor-cofactor binding pocket; inhibition site 573065002657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065002658 catalytic residue [active] 573065002659 trehalose synthase; Region: treS_nterm; TIGR02456 573065002660 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 573065002661 Ca binding site [ion binding]; other site 573065002662 active site 573065002663 catalytic site [active] 573065002664 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 573065002665 heme-binding site [chemical binding]; other site 573065002666 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065002667 putative CheW interface [polypeptide binding]; other site 573065002668 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 573065002669 S17 interaction site [polypeptide binding]; other site 573065002670 S8 interaction site; other site 573065002671 16S rRNA interaction site [nucleotide binding]; other site 573065002672 streptomycin interaction site [chemical binding]; other site 573065002673 23S rRNA interaction site [nucleotide binding]; other site 573065002674 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 573065002675 30S ribosomal protein S7; Validated; Region: PRK05302 573065002676 elongation factor G; Reviewed; Region: PRK00007 573065002677 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 573065002678 G1 box; other site 573065002679 putative GEF interaction site [polypeptide binding]; other site 573065002680 GTP/Mg2+ binding site [chemical binding]; other site 573065002681 Switch I region; other site 573065002682 G2 box; other site 573065002683 G3 box; other site 573065002684 Switch II region; other site 573065002685 G4 box; other site 573065002686 G5 box; other site 573065002687 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573065002688 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 573065002689 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 573065002690 elongation factor Tu; Reviewed; Region: PRK00049 573065002691 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 573065002692 G1 box; other site 573065002693 GEF interaction site [polypeptide binding]; other site 573065002694 GTP/Mg2+ binding site [chemical binding]; other site 573065002695 Switch I region; other site 573065002696 G2 box; other site 573065002697 G3 box; other site 573065002698 Switch II region; other site 573065002699 G4 box; other site 573065002700 G5 box; other site 573065002701 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 573065002702 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 573065002703 Antibiotic Binding Site [chemical binding]; other site 573065002704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573065002705 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 573065002706 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 573065002707 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 573065002708 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 573065002709 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 573065002710 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 573065002711 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 573065002712 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 573065002713 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 573065002714 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 573065002715 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 573065002716 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 573065002717 putative translocon binding site; other site 573065002718 protein-rRNA interface [nucleotide binding]; other site 573065002719 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 573065002720 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 573065002721 G-X-X-G motif; other site 573065002722 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 573065002723 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 573065002724 23S rRNA interface [nucleotide binding]; other site 573065002725 5S rRNA interface [nucleotide binding]; other site 573065002726 putative antibiotic binding site [chemical binding]; other site 573065002727 L25 interface [polypeptide binding]; other site 573065002728 L27 interface [polypeptide binding]; other site 573065002729 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 573065002730 putative translocon interaction site; other site 573065002731 23S rRNA interface [nucleotide binding]; other site 573065002732 signal recognition particle (SRP54) interaction site; other site 573065002733 L23 interface [polypeptide binding]; other site 573065002734 trigger factor interaction site; other site 573065002735 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 573065002736 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 573065002737 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 573065002738 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 573065002739 RNA binding site [nucleotide binding]; other site 573065002740 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 573065002741 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 573065002742 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 573065002743 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 573065002744 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 573065002745 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 573065002746 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573065002747 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573065002748 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 573065002749 23S rRNA interface [nucleotide binding]; other site 573065002750 L21e interface [polypeptide binding]; other site 573065002751 5S rRNA interface [nucleotide binding]; other site 573065002752 L27 interface [polypeptide binding]; other site 573065002753 L5 interface [polypeptide binding]; other site 573065002754 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 573065002755 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 573065002756 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 573065002757 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 573065002758 23S rRNA binding site [nucleotide binding]; other site 573065002759 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 573065002760 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 573065002761 SecY translocase; Region: SecY; pfam00344 573065002762 adenylate kinase; Provisional; Region: PRK14532 573065002763 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 573065002764 AMP-binding site [chemical binding]; other site 573065002765 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 573065002766 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 573065002767 30S ribosomal protein S13; Region: bact_S13; TIGR03631 573065002768 30S ribosomal protein S11; Validated; Region: PRK05309 573065002769 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 573065002770 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 573065002771 alphaNTD - beta interaction site [polypeptide binding]; other site 573065002772 alphaNTD homodimer interface [polypeptide binding]; other site 573065002773 alphaNTD - beta' interaction site [polypeptide binding]; other site 573065002774 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 573065002775 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 573065002776 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 573065002777 Uncharacterized conserved protein [Function unknown]; Region: COG3379 573065002778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065002779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573065002780 putative substrate translocation pore; other site 573065002781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065002782 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573065002783 putative substrate translocation pore; other site 573065002784 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 573065002785 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573065002786 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573065002787 protein binding site [polypeptide binding]; other site 573065002788 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573065002789 protein binding site [polypeptide binding]; other site 573065002790 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 573065002791 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 573065002792 diiron binding motif [ion binding]; other site 573065002793 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 573065002794 Predicted membrane protein [Function unknown]; Region: COG1238 573065002795 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573065002796 MarR family; Region: MarR_2; pfam12802 573065002797 MarR family; Region: MarR_2; cl17246 573065002798 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 573065002799 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573065002800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065002801 Walker A/P-loop; other site 573065002802 ATP binding site [chemical binding]; other site 573065002803 Q-loop/lid; other site 573065002804 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573065002805 ABC transporter signature motif; other site 573065002806 Walker B; other site 573065002807 ABC transporter; Region: ABC_tran_2; pfam12848 573065002808 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573065002809 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 573065002810 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573065002811 Sel1-like repeats; Region: SEL1; smart00671 573065002812 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 573065002813 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065002814 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 573065002815 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 573065002816 glutaminase; Provisional; Region: PRK00971 573065002817 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 573065002818 hypothetical protein; Validated; Region: PRK00029 573065002819 Uncharacterized conserved protein [Function unknown]; Region: COG0397 573065002820 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 573065002821 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065002822 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065002823 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065002824 WAHD domain of WASH complex; Region: WASH_WAHD; pfam11945 573065002825 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 573065002826 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573065002827 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 573065002828 acyl-activating enzyme (AAE) consensus motif; other site 573065002829 putative AMP binding site [chemical binding]; other site 573065002830 putative active site [active] 573065002831 putative CoA binding site [chemical binding]; other site 573065002832 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 573065002833 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 573065002834 active site 573065002835 active site 573065002836 CsbD-like; Region: CsbD; cl17424 573065002837 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 573065002838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573065002839 Histidine kinase; Region: HisKA_2; pfam07568 573065002840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065002841 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573065002842 putative substrate translocation pore; other site 573065002843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065002844 sequence-specific DNA binding site [nucleotide binding]; other site 573065002845 salt bridge; other site 573065002846 short chain dehydrogenase; Provisional; Region: PRK06701 573065002847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065002848 NAD(P) binding site [chemical binding]; other site 573065002849 active site 573065002850 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 573065002851 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 573065002852 ThiC-associated domain; Region: ThiC-associated; pfam13667 573065002853 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 573065002854 Uncharacterized conserved protein [Function unknown]; Region: COG2013 573065002855 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 573065002856 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 573065002857 Peptidase family M50; Region: Peptidase_M50; pfam02163 573065002858 active site 573065002859 putative substrate binding region [chemical binding]; other site 573065002860 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065002861 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573065002862 putative CheW interface [polypeptide binding]; other site 573065002863 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065002864 putative CheW interface [polypeptide binding]; other site 573065002865 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 573065002866 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 573065002867 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 573065002868 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573065002869 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 573065002870 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573065002871 alpha-galactosidase; Region: PLN02808; cl17638 573065002872 Predicted transcriptional regulator [Transcription]; Region: COG2378 573065002873 HTH domain; Region: HTH_11; pfam08279 573065002874 WYL domain; Region: WYL; pfam13280 573065002875 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 573065002876 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 573065002877 active site 573065002878 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 573065002879 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 573065002880 tetramer interface [polypeptide binding]; other site 573065002881 active site 573065002882 Mg2+/Mn2+ binding site [ion binding]; other site 573065002883 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 573065002884 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 573065002885 dimer interface [polypeptide binding]; other site 573065002886 active site 573065002887 citrylCoA binding site [chemical binding]; other site 573065002888 oxalacetate/citrate binding site [chemical binding]; other site 573065002889 coenzyme A binding site [chemical binding]; other site 573065002890 catalytic triad [active] 573065002891 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 573065002892 2-methylcitrate dehydratase; Region: prpD; TIGR02330 573065002893 Low affinity iron permease; Region: Iron_permease; pfam04120 573065002894 Isochorismatase family; Region: Isochorismatase; pfam00857 573065002895 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 573065002896 catalytic triad [active] 573065002897 conserved cis-peptide bond; other site 573065002898 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 573065002899 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573065002900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065002901 putative active site [active] 573065002902 heme pocket [chemical binding]; other site 573065002903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065002904 dimer interface [polypeptide binding]; other site 573065002905 phosphorylation site [posttranslational modification] 573065002906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065002907 ATP binding site [chemical binding]; other site 573065002908 Mg2+ binding site [ion binding]; other site 573065002909 G-X-G motif; other site 573065002910 Response regulator receiver domain; Region: Response_reg; pfam00072 573065002911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065002912 active site 573065002913 phosphorylation site [posttranslational modification] 573065002914 intermolecular recognition site; other site 573065002915 dimerization interface [polypeptide binding]; other site 573065002916 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 573065002917 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573065002918 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 573065002919 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573065002920 Walker A/P-loop; other site 573065002921 ATP binding site [chemical binding]; other site 573065002922 Q-loop/lid; other site 573065002923 ABC transporter signature motif; other site 573065002924 Walker B; other site 573065002925 D-loop; other site 573065002926 H-loop/switch region; other site 573065002927 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 573065002928 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 573065002929 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 573065002930 MerC mercury resistance protein; Region: MerC; pfam03203 573065002931 PhoD-like phosphatase; Region: PhoD; pfam09423 573065002932 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 573065002933 putative active site [active] 573065002934 putative metal binding site [ion binding]; other site 573065002935 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573065002936 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 573065002937 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065002938 N-terminal plug; other site 573065002939 ligand-binding site [chemical binding]; other site 573065002940 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573065002941 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 573065002942 Walker A/P-loop; other site 573065002943 ATP binding site [chemical binding]; other site 573065002944 Q-loop/lid; other site 573065002945 ABC transporter signature motif; other site 573065002946 Walker B; other site 573065002947 D-loop; other site 573065002948 H-loop/switch region; other site 573065002949 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 573065002950 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 573065002951 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 573065002952 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 573065002953 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065002954 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065002955 N-terminal plug; other site 573065002956 ligand-binding site [chemical binding]; other site 573065002957 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 573065002958 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 573065002959 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 573065002960 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 573065002961 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573065002962 homodimer interface [polypeptide binding]; other site 573065002963 substrate-cofactor binding pocket; other site 573065002964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065002965 catalytic residue [active] 573065002966 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 573065002967 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 573065002968 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 573065002969 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 573065002970 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065002971 N-terminal plug; other site 573065002972 ligand-binding site [chemical binding]; other site 573065002973 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 573065002974 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 573065002975 CopC domain; Region: CopC; cl01012 573065002976 Copper resistance protein D; Region: CopD; cl00563 573065002977 Protein of unknown function (DUF461); Region: DUF461; pfam04314 573065002978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065002979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065002980 dimer interface [polypeptide binding]; other site 573065002981 phosphorylation site [posttranslational modification] 573065002982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065002983 ATP binding site [chemical binding]; other site 573065002984 Mg2+ binding site [ion binding]; other site 573065002985 G-X-G motif; other site 573065002986 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 573065002987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065002988 active site 573065002989 phosphorylation site [posttranslational modification] 573065002990 intermolecular recognition site; other site 573065002991 dimerization interface [polypeptide binding]; other site 573065002992 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573065002993 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065002994 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065002995 N-terminal plug; other site 573065002996 ligand-binding site [chemical binding]; other site 573065002997 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 573065002998 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 573065002999 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 573065003000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065003001 dimerization interface [polypeptide binding]; other site 573065003002 putative DNA binding site [nucleotide binding]; other site 573065003003 putative Zn2+ binding site [ion binding]; other site 573065003004 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 573065003005 amphipathic channel; other site 573065003006 Asn-Pro-Ala signature motifs; other site 573065003007 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 573065003008 ArsC family; Region: ArsC; pfam03960 573065003009 catalytic residues [active] 573065003010 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 573065003011 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573065003012 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 573065003013 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 573065003014 putative catalytic site [active] 573065003015 putative metal binding site [ion binding]; other site 573065003016 putative phosphate binding site [ion binding]; other site 573065003017 WYL domain; Region: WYL; cl14852 573065003018 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065003019 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065003020 DNA binding site [nucleotide binding] 573065003021 domain linker motif; other site 573065003022 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 573065003023 putative ligand binding site [chemical binding]; other site 573065003024 putative dimerization interface [polypeptide binding]; other site 573065003025 Predicted deacylase [General function prediction only]; Region: COG3608 573065003026 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 573065003027 active site 573065003028 Zn binding site [ion binding]; other site 573065003029 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 573065003030 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065003031 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065003032 DNA binding residues [nucleotide binding] 573065003033 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 573065003034 putative binding surface; other site 573065003035 active site 573065003036 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 573065003037 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573065003038 catalytic loop [active] 573065003039 iron binding site [ion binding]; other site 573065003040 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 573065003041 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 573065003042 nudix motif; other site 573065003043 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573065003044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065003045 Coenzyme A binding pocket [chemical binding]; other site 573065003046 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 573065003047 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 573065003048 NADP binding site [chemical binding]; other site 573065003049 Predicted transcriptional regulators [Transcription]; Region: COG1733 573065003050 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 573065003051 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 573065003052 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 573065003053 active site 573065003054 intersubunit interface [polypeptide binding]; other site 573065003055 catalytic residue [active] 573065003056 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 573065003057 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 573065003058 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 573065003059 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 573065003060 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 573065003061 dimer interface [polypeptide binding]; other site 573065003062 active site 573065003063 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 573065003064 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573065003065 substrate binding site [chemical binding]; other site 573065003066 oxyanion hole (OAH) forming residues; other site 573065003067 trimer interface [polypeptide binding]; other site 573065003068 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 573065003069 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 573065003070 putative hydrolase; Provisional; Region: PRK11460 573065003071 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573065003072 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 573065003073 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573065003074 HSP70 interaction site [polypeptide binding]; other site 573065003075 Uncharacterized conserved protein [Function unknown]; Region: COG3791 573065003076 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 573065003077 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 573065003078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 573065003079 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 573065003080 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 573065003081 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 573065003082 metal ion-dependent adhesion site (MIDAS); other site 573065003083 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 573065003084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 573065003085 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573065003086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573065003087 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 573065003088 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 573065003089 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 573065003090 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 573065003091 heme binding pocket [chemical binding]; other site 573065003092 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 573065003093 domain interactions; other site 573065003094 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 573065003095 Predicted membrane protein [Function unknown]; Region: COG2860 573065003096 UPF0126 domain; Region: UPF0126; pfam03458 573065003097 UPF0126 domain; Region: UPF0126; pfam03458 573065003098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573065003099 ATP binding site [chemical binding]; other site 573065003100 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 573065003101 putative Mg++ binding site [ion binding]; other site 573065003102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573065003103 nucleotide binding region [chemical binding]; other site 573065003104 ATP-binding site [chemical binding]; other site 573065003105 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 573065003106 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573065003107 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis]; Region: COG1188 573065003108 RNA binding surface [nucleotide binding]; other site 573065003109 Ferredoxin [Energy production and conversion]; Region: COG1146 573065003110 4Fe-4S binding domain; Region: Fer4; pfam00037 573065003111 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 573065003112 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 573065003113 ArsC family; Region: ArsC; pfam03960 573065003114 catalytic residues [active] 573065003115 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003116 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003117 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573065003118 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002 573065003119 active site 573065003120 Ion transport protein; Region: Ion_trans; pfam00520 573065003121 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 573065003122 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 573065003123 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 573065003124 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 573065003125 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 573065003126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065003127 dimer interface [polypeptide binding]; other site 573065003128 phosphorylation site [posttranslational modification] 573065003129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065003130 ATP binding site [chemical binding]; other site 573065003131 Mg2+ binding site [ion binding]; other site 573065003132 G-X-G motif; other site 573065003133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573065003134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065003135 active site 573065003136 phosphorylation site [posttranslational modification] 573065003137 intermolecular recognition site; other site 573065003138 dimerization interface [polypeptide binding]; other site 573065003139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065003140 DNA binding site [nucleotide binding] 573065003141 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 573065003142 MgtE intracellular N domain; Region: MgtE_N; pfam03448 573065003143 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 573065003144 Divalent cation transporter; Region: MgtE; pfam01769 573065003145 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 573065003146 catalytic residues [active] 573065003147 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 573065003148 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 573065003149 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 573065003150 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 573065003151 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 573065003152 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 573065003153 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 573065003154 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 573065003155 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 573065003156 Walker A/P-loop; other site 573065003157 ATP binding site [chemical binding]; other site 573065003158 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 573065003159 ABC transporter signature motif; other site 573065003160 Walker B; other site 573065003161 D-loop; other site 573065003162 H-loop/switch region; other site 573065003163 TraB family; Region: TraB; pfam01963 573065003164 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 573065003165 Thioredoxin; Region: Thioredoxin_4; pfam13462 573065003166 Thioredoxin; Region: Thioredoxin_4; pfam13462 573065003167 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 573065003168 Protein of unknown function (DUF721); Region: DUF721; cl02324 573065003169 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 573065003170 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573065003171 minor groove reading motif; other site 573065003172 helix-hairpin-helix signature motif; other site 573065003173 substrate binding pocket [chemical binding]; other site 573065003174 active site 573065003175 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 573065003176 DNA binding and oxoG recognition site [nucleotide binding] 573065003177 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573065003178 DNA methylase; Region: N6_N4_Mtase; pfam01555 573065003179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065003180 S-adenosylmethionine binding site [chemical binding]; other site 573065003181 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 573065003182 RNA/DNA hybrid binding site [nucleotide binding]; other site 573065003183 active site 573065003184 Protein of unknown function (DUF805); Region: DUF805; pfam05656 573065003185 Protein of unknown function (DUF805); Region: DUF805; pfam05656 573065003186 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 573065003187 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 573065003188 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 573065003189 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 573065003190 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 573065003191 putative active site [active] 573065003192 dihydroorotase; Validated; Region: PRK09060 573065003193 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573065003194 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 573065003195 active site 573065003196 enoyl-CoA hydratase; Provisional; Region: PRK06688 573065003197 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573065003198 substrate binding site [chemical binding]; other site 573065003199 oxyanion hole (OAH) forming residues; other site 573065003200 trimer interface [polypeptide binding]; other site 573065003201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065003202 Coenzyme A binding pocket [chemical binding]; other site 573065003203 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 573065003204 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 573065003205 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 573065003206 active site 573065003207 NTP binding site [chemical binding]; other site 573065003208 metal binding triad [ion binding]; metal-binding site 573065003209 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 573065003210 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 573065003211 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 573065003212 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 573065003213 catalytic triad [active] 573065003214 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 573065003215 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 573065003216 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 573065003217 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 573065003218 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 573065003219 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 573065003220 [2Fe-2S] cluster binding site [ion binding]; other site 573065003221 cytochrome b; Provisional; Region: CYTB; MTH00156 573065003222 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 573065003223 Qi binding site; other site 573065003224 intrachain domain interface; other site 573065003225 interchain domain interface [polypeptide binding]; other site 573065003226 heme bH binding site [chemical binding]; other site 573065003227 heme bL binding site [chemical binding]; other site 573065003228 Qo binding site; other site 573065003229 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 573065003230 interchain domain interface [polypeptide binding]; other site 573065003231 intrachain domain interface; other site 573065003232 Qi binding site; other site 573065003233 Qo binding site; other site 573065003234 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 573065003235 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 573065003236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573065003237 Zn2+ binding site [ion binding]; other site 573065003238 Mg2+ binding site [ion binding]; other site 573065003239 GTP-binding protein YchF; Reviewed; Region: PRK09601 573065003240 YchF GTPase; Region: YchF; cd01900 573065003241 G1 box; other site 573065003242 GTP/Mg2+ binding site [chemical binding]; other site 573065003243 Switch I region; other site 573065003244 G2 box; other site 573065003245 Switch II region; other site 573065003246 G3 box; other site 573065003247 G4 box; other site 573065003248 G5 box; other site 573065003249 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 573065003250 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573065003251 Beta-lactamase; Region: Beta-lactamase; pfam00144 573065003252 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 573065003253 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 573065003254 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 573065003255 active site 573065003256 TDP-binding site; other site 573065003257 acceptor substrate-binding pocket; other site 573065003258 homodimer interface [polypeptide binding]; other site 573065003259 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 573065003260 putative active site [active] 573065003261 catalytic residue [active] 573065003262 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 573065003263 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 573065003264 5S rRNA interface [nucleotide binding]; other site 573065003265 CTC domain interface [polypeptide binding]; other site 573065003266 L16 interface [polypeptide binding]; other site 573065003267 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 573065003268 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 573065003269 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573065003270 active site 573065003271 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 573065003272 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 573065003273 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 573065003274 Uncharacterized conserved protein [Function unknown]; Region: COG1565 573065003275 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 573065003276 Membrane fusogenic activity; Region: BMFP; pfam04380 573065003277 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 573065003278 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 573065003279 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 573065003280 Phytase; Region: Phytase; cl17685 573065003281 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065003282 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003283 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003284 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 573065003285 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573065003286 MarR family; Region: MarR; pfam01047 573065003287 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 573065003288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573065003289 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573065003290 active site 573065003291 catalytic tetrad [active] 573065003292 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573065003293 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573065003294 O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080 573065003295 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573065003296 homodimer interface [polypeptide binding]; other site 573065003297 substrate-cofactor binding pocket; other site 573065003298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065003299 catalytic residue [active] 573065003300 homoserine O-acetyltransferase; Provisional; Region: PRK08775 573065003301 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 573065003302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065003303 short chain dehydrogenase; Provisional; Region: PRK07024 573065003304 NAD(P) binding site [chemical binding]; other site 573065003305 active site 573065003306 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573065003307 EamA-like transporter family; Region: EamA; pfam00892 573065003308 EamA-like transporter family; Region: EamA; pfam00892 573065003309 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 573065003310 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 573065003311 nucleotide binding site [chemical binding]; other site 573065003312 substrate binding site [chemical binding]; other site 573065003313 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 573065003314 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 573065003315 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 573065003316 recombination factor protein RarA; Reviewed; Region: PRK13342 573065003317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065003318 Walker A motif; other site 573065003319 ATP binding site [chemical binding]; other site 573065003320 Walker B motif; other site 573065003321 arginine finger; other site 573065003322 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 573065003323 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 573065003324 Protein of unknown function (DUF805); Region: DUF805; pfam05656 573065003325 Protein of unknown function (DUF805); Region: DUF805; pfam05656 573065003326 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573065003327 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573065003328 active site 573065003329 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 573065003330 von Willebrand factor type A domain; Region: VWA_2; pfam13519 573065003331 metal ion-dependent adhesion site (MIDAS); other site 573065003332 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 573065003333 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 573065003334 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 573065003335 metal ion-dependent adhesion site (MIDAS); other site 573065003336 Predicted membrane protein [Function unknown]; Region: COG3152 573065003337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 573065003338 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 573065003339 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 573065003340 putative metal binding site [ion binding]; other site 573065003341 putative catalytic site [active] 573065003342 putative phosphate binding site [ion binding]; other site 573065003343 putative metal binding site [ion binding]; other site 573065003344 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 573065003345 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 573065003346 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 573065003347 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 573065003348 hinge; other site 573065003349 active site 573065003350 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 573065003351 hypothetical protein; Provisional; Region: PRK02853 573065003352 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 573065003353 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 573065003354 rRNA binding site [nucleotide binding]; other site 573065003355 predicted 30S ribosome binding site; other site 573065003356 Maf-like protein; Region: Maf; pfam02545 573065003357 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 573065003358 active site 573065003359 dimer interface [polypeptide binding]; other site 573065003360 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 573065003361 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 573065003362 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 573065003363 ring oligomerisation interface [polypeptide binding]; other site 573065003364 ATP/Mg binding site [chemical binding]; other site 573065003365 stacking interactions; other site 573065003366 hinge regions; other site 573065003367 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 573065003368 oligomerisation interface [polypeptide binding]; other site 573065003369 mobile loop; other site 573065003370 roof hairpin; other site 573065003371 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 573065003372 putative catalytic site [active] 573065003373 putative metal binding site [ion binding]; other site 573065003374 putative phosphate binding site [ion binding]; other site 573065003375 TraB family; Region: TraB; pfam01963 573065003376 Predicted transcriptional regulator [Transcription]; Region: COG3655 573065003377 salt bridge; other site 573065003378 non-specific DNA binding site [nucleotide binding]; other site 573065003379 sequence-specific DNA binding site [nucleotide binding]; other site 573065003380 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 573065003381 active site 573065003382 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 573065003383 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 573065003384 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 573065003385 MoxR-like ATPases [General function prediction only]; Region: COG0714 573065003386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065003387 Walker A motif; other site 573065003388 ATP binding site [chemical binding]; other site 573065003389 Walker B motif; other site 573065003390 arginine finger; other site 573065003391 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 573065003392 Protein of unknown function DUF58; Region: DUF58; pfam01882 573065003393 Aerotolerance regulator N-terminal; Region: BatA; cl06567 573065003394 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 573065003395 histidine kinase; Provisional; Region: PRK13557 573065003396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065003397 putative active site [active] 573065003398 heme pocket [chemical binding]; other site 573065003399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065003400 dimer interface [polypeptide binding]; other site 573065003401 phosphorylation site [posttranslational modification] 573065003402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065003403 ATP binding site [chemical binding]; other site 573065003404 Mg2+ binding site [ion binding]; other site 573065003405 G-X-G motif; other site 573065003406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065003407 active site 573065003408 phosphorylation site [posttranslational modification] 573065003409 intermolecular recognition site; other site 573065003410 dimerization interface [polypeptide binding]; other site 573065003411 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065003412 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065003413 DNA binding site [nucleotide binding] 573065003414 domain linker motif; other site 573065003415 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573065003416 dimerization interface [polypeptide binding]; other site 573065003417 ligand binding site [chemical binding]; other site 573065003418 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 573065003419 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065003420 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 573065003422 Putative glucoamylase; Region: Glycoamylase; pfam10091 573065003423 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 573065003424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573065003425 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065003426 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 573065003427 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573065003428 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573065003429 MFS/sugar transport protein; Region: MFS_2; pfam13347 573065003430 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 573065003431 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 573065003432 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 573065003433 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 573065003434 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065003435 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065003436 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065003437 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 573065003438 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065003439 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065003440 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065003441 Secretin and TonB N terminus short domain; Region: STN; smart00965 573065003442 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065003443 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003444 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003445 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 573065003446 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065003447 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 573065003448 Cupin-like domain; Region: Cupin_8; pfam13621 573065003449 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 573065003450 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003451 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065003452 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003453 amino acid transporter; Region: 2A0306; TIGR00909 573065003454 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 573065003455 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 573065003456 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573065003457 Walker A/P-loop; other site 573065003458 ATP binding site [chemical binding]; other site 573065003459 Q-loop/lid; other site 573065003460 ABC transporter signature motif; other site 573065003461 Walker B; other site 573065003462 D-loop; other site 573065003463 H-loop/switch region; other site 573065003464 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573065003465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065003466 dimer interface [polypeptide binding]; other site 573065003467 conserved gate region; other site 573065003468 putative PBP binding loops; other site 573065003469 ABC-ATPase subunit interface; other site 573065003470 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 573065003471 NMT1-like family; Region: NMT1_2; pfam13379 573065003472 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573065003473 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573065003474 Peptidase family M23; Region: Peptidase_M23; pfam01551 573065003475 Preprotein translocase subunit; Region: YajC; pfam02699 573065003476 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 573065003477 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 573065003478 Protein export membrane protein; Region: SecD_SecF; pfam02355 573065003479 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 573065003480 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 573065003481 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 573065003482 Glucose inhibited division protein A; Region: GIDA; pfam01134 573065003483 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 573065003484 active site 573065003485 zinc binding site [ion binding]; other site 573065003486 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 573065003487 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573065003488 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573065003489 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 573065003490 Rod binding protein; Region: Rod-binding; cl01626 573065003491 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 573065003492 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 573065003493 Class II flagellar assembly regulator; Region: FliX; pfam10768 573065003494 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 573065003495 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 573065003496 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 573065003497 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 573065003498 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 573065003499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065003500 Walker A motif; other site 573065003501 ATP binding site [chemical binding]; other site 573065003502 Walker B motif; other site 573065003503 arginine finger; other site 573065003504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065003505 Walker A motif; other site 573065003506 ATP binding site [chemical binding]; other site 573065003507 Walker B motif; other site 573065003508 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573065003509 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 573065003510 tandem repeat interface [polypeptide binding]; other site 573065003511 oligomer interface [polypeptide binding]; other site 573065003512 active site residues [active] 573065003513 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 573065003514 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 573065003515 tandem repeat interface [polypeptide binding]; other site 573065003516 oligomer interface [polypeptide binding]; other site 573065003517 active site residues [active] 573065003518 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 573065003519 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 573065003520 active site residue [active] 573065003521 MEKHLA domain; Region: MEKHLA; pfam08670 573065003522 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573065003523 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065003524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065003525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573065003526 dimerization interface [polypeptide binding]; other site 573065003527 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065003528 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003529 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003530 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573065003531 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 573065003532 putative NAD(P) binding site [chemical binding]; other site 573065003533 active site 573065003534 putative substrate binding site [chemical binding]; other site 573065003535 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 573065003536 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 573065003537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065003538 S-adenosylmethionine binding site [chemical binding]; other site 573065003539 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573065003540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065003541 Coenzyme A binding pocket [chemical binding]; other site 573065003542 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 573065003543 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 573065003544 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573065003545 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 573065003546 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 573065003547 active site 573065003548 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573065003549 dimer interface [polypeptide binding]; other site 573065003550 substrate binding site [chemical binding]; other site 573065003551 catalytic residues [active] 573065003552 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573065003553 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 573065003554 putative DNA binding site [nucleotide binding]; other site 573065003555 putative Zn2+ binding site [ion binding]; other site 573065003556 AsnC family; Region: AsnC_trans_reg; pfam01037 573065003557 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 573065003558 active site 573065003559 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 573065003560 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573065003561 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573065003562 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573065003563 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065003564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065003565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065003566 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 573065003567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065003568 FeS/SAM binding site; other site 573065003569 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573065003570 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573065003571 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573065003572 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 573065003573 Autotransporter beta-domain; Region: Autotransporter; smart00869 573065003574 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 573065003575 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 573065003576 G1 box; other site 573065003577 putative GEF interaction site [polypeptide binding]; other site 573065003578 GTP/Mg2+ binding site [chemical binding]; other site 573065003579 Switch I region; other site 573065003580 G2 box; other site 573065003581 G3 box; other site 573065003582 Switch II region; other site 573065003583 G4 box; other site 573065003584 G5 box; other site 573065003585 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 573065003586 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 573065003587 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 573065003588 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065003589 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 573065003590 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 573065003591 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 573065003592 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 573065003593 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065003594 N-terminal plug; other site 573065003595 ligand-binding site [chemical binding]; other site 573065003596 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 573065003597 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 573065003598 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 573065003599 active site 573065003600 substrate binding site [chemical binding]; other site 573065003601 FMN binding site [chemical binding]; other site 573065003602 putative catalytic residues [active] 573065003603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 573065003604 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 573065003605 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 573065003606 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 573065003607 ApbE family; Region: ApbE; pfam02424 573065003608 Flavodoxin; Region: Flavodoxin_1; pfam00258 573065003609 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 573065003610 FAD binding pocket [chemical binding]; other site 573065003611 conserved FAD binding motif [chemical binding]; other site 573065003612 phosphate binding motif [ion binding]; other site 573065003613 beta-alpha-beta structure motif; other site 573065003614 NAD binding pocket [chemical binding]; other site 573065003615 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 573065003616 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 573065003617 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 573065003618 hypothetical protein; Provisional; Region: PRK08912 573065003619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573065003620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065003621 homodimer interface [polypeptide binding]; other site 573065003622 catalytic residue [active] 573065003623 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065003624 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065003625 N-terminal plug; other site 573065003626 ligand-binding site [chemical binding]; other site 573065003627 TPR repeat; Region: TPR_11; pfam13414 573065003628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065003629 TPR motif; other site 573065003630 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 573065003631 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 573065003632 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 573065003633 tetrameric interface [polypeptide binding]; other site 573065003634 NAD binding site [chemical binding]; other site 573065003635 catalytic residues [active] 573065003636 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573065003637 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573065003638 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 573065003639 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065003640 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003641 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003642 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 573065003643 Proline dehydrogenase; Region: Pro_dh; pfam01619 573065003644 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 573065003645 Glutamate binding site [chemical binding]; other site 573065003646 NAD binding site [chemical binding]; other site 573065003647 catalytic residues [active] 573065003648 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573065003649 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065003650 putative DNA binding site [nucleotide binding]; other site 573065003651 putative Zn2+ binding site [ion binding]; other site 573065003652 AsnC family; Region: AsnC_trans_reg; pfam01037 573065003653 Glycoside hydrolase family 94 N-terminal-like domain of NdvB-like proteins; Region: GH94N_NdvB_like; cd11748 573065003654 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 573065003655 Penicillinase repressor; Region: Pencillinase_R; cl17580 573065003656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 573065003657 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 573065003658 Pectic acid lyase; Region: Pec_lyase; pfam09492 573065003659 Response regulator receiver domain; Region: Response_reg; pfam00072 573065003660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065003661 active site 573065003662 phosphorylation site [posttranslational modification] 573065003663 intermolecular recognition site; other site 573065003664 dimerization interface [polypeptide binding]; other site 573065003665 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 573065003666 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 573065003667 active site 573065003668 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 573065003669 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573065003670 NodB motif; other site 573065003671 putative active site [active] 573065003672 putative catalytic site [active] 573065003673 putative Zn binding site [ion binding]; other site 573065003674 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 573065003675 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 573065003676 DXD motif; other site 573065003677 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 573065003678 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 573065003679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573065003680 substrate binding site [chemical binding]; other site 573065003681 dimer interface [polypeptide binding]; other site 573065003682 ATP binding site [chemical binding]; other site 573065003683 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 573065003684 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 573065003685 active site 573065003686 rhamnose-proton symporter; Provisional; Region: PRK13499 573065003687 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 573065003688 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 573065003689 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573065003690 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573065003691 active site 573065003692 catalytic tetrad [active] 573065003693 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 573065003694 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573065003695 metal binding site [ion binding]; metal-binding site 573065003696 putative dimer interface [polypeptide binding]; other site 573065003697 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 573065003698 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 573065003699 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573065003700 catalytic residue [active] 573065003701 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 573065003702 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 573065003703 Walker A motif; other site 573065003704 hexamer interface [polypeptide binding]; other site 573065003705 ATP binding site [chemical binding]; other site 573065003706 Walker B motif; other site 573065003707 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 573065003708 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 573065003709 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 573065003710 VirB7 interaction site; other site 573065003711 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 573065003712 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 573065003713 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 573065003714 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 573065003715 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 573065003716 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573065003717 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573065003718 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573065003719 catalytic residue [active] 573065003720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 573065003721 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 573065003722 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 573065003723 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 573065003724 Multicopper oxidase; Region: Cu-oxidase; pfam00394 573065003725 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 573065003726 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 573065003727 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065003728 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065003729 DNA binding site [nucleotide binding] 573065003730 domain linker motif; other site 573065003731 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573065003732 dimerization interface [polypeptide binding]; other site 573065003733 ligand binding site [chemical binding]; other site 573065003734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065003735 metabolite-proton symporter; Region: 2A0106; TIGR00883 573065003736 putative substrate translocation pore; other site 573065003737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065003738 Response regulator receiver domain; Region: Response_reg; pfam00072 573065003739 active site 573065003740 phosphorylation site [posttranslational modification] 573065003741 intermolecular recognition site; other site 573065003742 dimerization interface [polypeptide binding]; other site 573065003743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065003744 Response regulator receiver domain; Region: Response_reg; pfam00072 573065003745 active site 573065003746 phosphorylation site [posttranslational modification] 573065003747 intermolecular recognition site; other site 573065003748 dimerization interface [polypeptide binding]; other site 573065003749 seryl-tRNA synthetase; Provisional; Region: PRK05431 573065003750 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 573065003751 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 573065003752 dimer interface [polypeptide binding]; other site 573065003753 active site 573065003754 motif 1; other site 573065003755 motif 2; other site 573065003756 motif 3; other site 573065003757 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 573065003758 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 573065003759 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 573065003760 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 573065003761 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 573065003762 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573065003763 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 573065003764 Sporulation related domain; Region: SPOR; pfam05036 573065003765 CAAX protease self-immunity; Region: Abi; pfam02517 573065003766 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 573065003767 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 573065003768 active site 573065003769 DNA binding site [nucleotide binding] 573065003770 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 573065003771 DNA binding site [nucleotide binding] 573065003772 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 573065003773 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573065003774 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 573065003775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573065003776 ATP binding site [chemical binding]; other site 573065003777 putative Mg++ binding site [ion binding]; other site 573065003778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573065003779 nucleotide binding region [chemical binding]; other site 573065003780 ATP-binding site [chemical binding]; other site 573065003781 DEAD/H associated; Region: DEAD_assoc; pfam08494 573065003782 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 573065003783 putative active site [active] 573065003784 putative metal binding site [ion binding]; other site 573065003785 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 573065003786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065003787 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573065003788 dimerization interface [polypeptide binding]; other site 573065003789 Domain of unknown function (DUF897); Region: DUF897; cl01312 573065003790 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065003791 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065003792 DNA binding site [nucleotide binding] 573065003793 domain linker motif; other site 573065003794 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 573065003795 putative dimerization interface [polypeptide binding]; other site 573065003796 putative ligand binding site [chemical binding]; other site 573065003797 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 573065003798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065003799 putative substrate translocation pore; other site 573065003800 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 573065003801 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003802 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003803 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 573065003804 trehalose synthase; Region: treS_nterm; TIGR02456 573065003805 active site 573065003806 catalytic site [active] 573065003807 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573065003808 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573065003809 nucleotide binding site [chemical binding]; other site 573065003810 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 573065003811 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 573065003812 putative DNA binding site [nucleotide binding]; other site 573065003813 putative homodimer interface [polypeptide binding]; other site 573065003814 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 573065003815 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 573065003816 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 573065003817 active site 573065003818 DNA binding site [nucleotide binding] 573065003819 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 573065003820 DNA binding site [nucleotide binding] 573065003821 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 573065003822 nucleotide binding site [chemical binding]; other site 573065003823 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573065003824 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573065003825 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 573065003826 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573065003827 PAS domain; Region: PAS_9; pfam13426 573065003828 PAS domain; Region: PAS_9; pfam13426 573065003829 PAS fold; Region: PAS_4; pfam08448 573065003830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065003831 PAS domain; Region: PAS_9; pfam13426 573065003832 putative active site [active] 573065003833 heme pocket [chemical binding]; other site 573065003834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065003835 putative active site [active] 573065003836 heme pocket [chemical binding]; other site 573065003837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065003838 dimer interface [polypeptide binding]; other site 573065003839 phosphorylation site [posttranslational modification] 573065003840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065003841 ATP binding site [chemical binding]; other site 573065003842 Mg2+ binding site [ion binding]; other site 573065003843 G-X-G motif; other site 573065003844 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573065003845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065003846 active site 573065003847 phosphorylation site [posttranslational modification] 573065003848 intermolecular recognition site; other site 573065003849 dimerization interface [polypeptide binding]; other site 573065003850 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 573065003851 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573065003852 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065003853 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065003854 DNA binding residues [nucleotide binding] 573065003855 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 573065003856 FecR protein; Region: FecR; pfam04773 573065003857 BNR repeat-like domain; Region: BNR_2; pfam13088 573065003858 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065003859 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065003860 putative pectinesterase; Region: PLN02432; cl01911 573065003861 Pectinesterase; Region: Pectinesterase; pfam01095 573065003862 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 573065003863 active site 573065003864 catalytic triad [active] 573065003865 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573065003866 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002 573065003867 active site 573065003868 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003869 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003870 Secretin and TonB N terminus short domain; Region: STN; smart00965 573065003871 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065003872 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003873 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065003874 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 573065003875 FecR protein; Region: FecR; pfam04773 573065003876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065003877 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573065003878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065003879 DNA binding residues [nucleotide binding] 573065003880 Domain of unknown function (DUF329); Region: DUF329; cl01144 573065003881 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 573065003882 lipoate-protein ligase B; Provisional; Region: PRK14341 573065003883 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 573065003884 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573065003885 active site 573065003886 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 573065003887 active site 573065003888 HIGH motif; other site 573065003889 nucleotide binding site [chemical binding]; other site 573065003890 active site 573065003891 KMSKS motif; other site 573065003892 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573065003893 DNA-binding site [nucleotide binding]; DNA binding site 573065003894 RNA-binding motif; other site 573065003895 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 573065003896 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 573065003897 AbgT putative transporter family; Region: ABG_transport; cl17431 573065003898 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 573065003899 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 573065003900 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 573065003901 TPP-binding site; other site 573065003902 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573065003903 PYR/PP interface [polypeptide binding]; other site 573065003904 dimer interface [polypeptide binding]; other site 573065003905 TPP binding site [chemical binding]; other site 573065003906 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573065003907 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 573065003908 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573065003909 substrate binding pocket [chemical binding]; other site 573065003910 chain length determination region; other site 573065003911 substrate-Mg2+ binding site; other site 573065003912 catalytic residues [active] 573065003913 aspartate-rich region 1; other site 573065003914 active site lid residues [active] 573065003915 aspartate-rich region 2; other site 573065003916 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 573065003917 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573065003918 catalytic core [active] 573065003919 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 573065003920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065003921 S-adenosylmethionine binding site [chemical binding]; other site 573065003922 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 573065003923 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 573065003924 Putative zinc-finger; Region: zf-HC2; pfam13490 573065003925 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 573065003926 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573065003927 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065003928 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065003929 DNA binding residues [nucleotide binding] 573065003930 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 573065003931 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573065003932 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 573065003933 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573065003934 PA14 domain; Region: PA14; cl08459 573065003935 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 573065003936 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 573065003937 putative active site [active] 573065003938 putative catalytic site [active] 573065003939 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 573065003940 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 573065003941 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573065003942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065003943 DNA-binding site [nucleotide binding]; DNA binding site 573065003944 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573065003945 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 573065003946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065003947 dimer interface [polypeptide binding]; other site 573065003948 phosphorylation site [posttranslational modification] 573065003949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065003950 ATP binding site [chemical binding]; other site 573065003951 Mg2+ binding site [ion binding]; other site 573065003952 G-X-G motif; other site 573065003953 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573065003954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065003955 active site 573065003956 phosphorylation site [posttranslational modification] 573065003957 intermolecular recognition site; other site 573065003958 dimerization interface [polypeptide binding]; other site 573065003959 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 573065003960 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 573065003961 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 573065003962 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 573065003963 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 573065003964 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 573065003965 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573065003966 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573065003967 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 573065003968 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 573065003969 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573065003970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573065003971 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573065003972 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 573065003973 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 573065003974 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 573065003975 SPFH domain / Band 7 family; Region: Band_7; pfam01145 573065003976 Thioredoxin; Region: Thioredoxin_4; pfam13462 573065003977 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 573065003978 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573065003979 MULE transposase domain; Region: MULE; pfam10551 573065003980 Uncharacterized conserved protein [Function unknown]; Region: COG3334 573065003981 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 573065003982 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 573065003983 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 573065003984 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 573065003985 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 573065003986 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065003987 dimer interface [polypeptide binding]; other site 573065003988 putative CheW interface [polypeptide binding]; other site 573065003989 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 573065003990 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 573065003991 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573065003992 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573065003993 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573065003994 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573065003995 Walker A/P-loop; other site 573065003996 ATP binding site [chemical binding]; other site 573065003997 Q-loop/lid; other site 573065003998 ABC transporter signature motif; other site 573065003999 Walker B; other site 573065004000 D-loop; other site 573065004001 H-loop/switch region; other site 573065004002 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 573065004003 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573065004004 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065004005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065004006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065004007 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065004008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065004009 non-specific DNA binding site [nucleotide binding]; other site 573065004010 salt bridge; other site 573065004011 sequence-specific DNA binding site [nucleotide binding]; other site 573065004012 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 573065004013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 573065004014 Peptidase family M48; Region: Peptidase_M48; cl12018 573065004015 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 573065004016 HemN C-terminal domain; Region: HemN_C; pfam06969 573065004017 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 573065004018 EamA-like transporter family; Region: EamA; pfam00892 573065004019 EamA-like transporter family; Region: EamA; pfam00892 573065004020 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 573065004021 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 573065004022 tetramer interface [polypeptide binding]; other site 573065004023 heme binding pocket [chemical binding]; other site 573065004024 NADPH binding site [chemical binding]; other site 573065004025 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 573065004026 PhnA protein; Region: PhnA; pfam03831 573065004027 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 573065004028 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 573065004029 Nucleoside recognition; Region: Gate; pfam07670 573065004030 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 573065004031 Porin subfamily; Region: Porin_2; pfam02530 573065004032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573065004033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065004034 active site 573065004035 phosphorylation site [posttranslational modification] 573065004036 intermolecular recognition site; other site 573065004037 dimerization interface [polypeptide binding]; other site 573065004038 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573065004039 DNA binding residues [nucleotide binding] 573065004040 dimerization interface [polypeptide binding]; other site 573065004041 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 573065004042 Na binding site [ion binding]; other site 573065004043 PAS fold; Region: PAS_7; pfam12860 573065004044 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065004045 putative active site [active] 573065004046 heme pocket [chemical binding]; other site 573065004047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065004048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065004049 dimer interface [polypeptide binding]; other site 573065004050 phosphorylation site [posttranslational modification] 573065004051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065004052 ATP binding site [chemical binding]; other site 573065004053 Mg2+ binding site [ion binding]; other site 573065004054 G-X-G motif; other site 573065004055 Response regulator receiver domain; Region: Response_reg; pfam00072 573065004056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065004057 active site 573065004058 phosphorylation site [posttranslational modification] 573065004059 intermolecular recognition site; other site 573065004060 dimerization interface [polypeptide binding]; other site 573065004061 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065004062 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065004063 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 573065004064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065004065 putative substrate translocation pore; other site 573065004066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065004067 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 573065004068 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573065004069 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065004070 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 573065004071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065004072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065004073 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 573065004074 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 573065004075 MobA/MobL family; Region: MobA_MobL; pfam03389 573065004076 AAA domain; Region: AAA_30; pfam13604 573065004077 Family description; Region: UvrD_C_2; pfam13538 573065004078 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 573065004079 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573065004080 Walker A motif; other site 573065004081 ATP binding site [chemical binding]; other site 573065004082 Walker B motif; other site 573065004083 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573065004084 active site 573065004085 NTP binding site [chemical binding]; other site 573065004086 metal binding triad [ion binding]; metal-binding site 573065004087 antibiotic binding site [chemical binding]; other site 573065004088 HEPN domain; Region: HEPN; cl00824 573065004089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065004090 non-specific DNA binding site [nucleotide binding]; other site 573065004091 salt bridge; other site 573065004092 sequence-specific DNA binding site [nucleotide binding]; other site 573065004093 Domain of unknown function (DUF955); Region: DUF955; cl01076 573065004094 Beta protein; Region: Beta_protein; pfam14350 573065004095 Helix-turn-helix domain; Region: HTH_17; cl17695 573065004096 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 573065004097 additional DNA contacts [nucleotide binding]; other site 573065004098 mismatch recognition site; other site 573065004099 active site 573065004100 zinc binding site [ion binding]; other site 573065004101 DNA intercalation site [nucleotide binding]; other site 573065004102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065004103 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065004104 salt bridge; other site 573065004105 non-specific DNA binding site [nucleotide binding]; other site 573065004106 sequence-specific DNA binding site [nucleotide binding]; other site 573065004107 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573065004108 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 573065004109 cofactor binding site; other site 573065004110 DNA binding site [nucleotide binding] 573065004111 substrate interaction site [chemical binding]; other site 573065004112 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 573065004113 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573065004114 Uncharacterized conserved protein [Function unknown]; Region: COG4933 573065004115 AAA domain; Region: AAA_18; pfam13238 573065004116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 573065004117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573065004118 Coenzyme A binding pocket [chemical binding]; other site 573065004119 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573065004120 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573065004121 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573065004122 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 573065004123 PA/protease or protease-like domain interface [polypeptide binding]; other site 573065004124 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 573065004125 Peptidase family M28; Region: Peptidase_M28; pfam04389 573065004126 metal binding site [ion binding]; metal-binding site 573065004127 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 573065004128 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 573065004129 putative MPT binding site; other site 573065004130 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 573065004131 Uncharacterized conserved protein [Function unknown]; Region: COG2898 573065004132 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 573065004133 Sporulation related domain; Region: SPOR; pfam05036 573065004134 pantoate--beta-alanine ligase; Region: panC; TIGR00018 573065004135 Pantoate-beta-alanine ligase; Region: PanC; cd00560 573065004136 active site 573065004137 ATP-binding site [chemical binding]; other site 573065004138 pantoate-binding site; other site 573065004139 HXXH motif; other site 573065004140 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 573065004141 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 573065004142 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573065004143 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573065004144 ligand binding site [chemical binding]; other site 573065004145 flexible hinge region; other site 573065004146 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 573065004147 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 573065004148 active site 573065004149 nucleophile elbow; other site 573065004150 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 573065004151 putative catalytic site [active] 573065004152 putative phosphate binding site [ion binding]; other site 573065004153 active site 573065004154 metal binding site A [ion binding]; metal-binding site 573065004155 DNA binding site [nucleotide binding] 573065004156 putative AP binding site [nucleotide binding]; other site 573065004157 putative metal binding site B [ion binding]; other site 573065004158 NnrU protein; Region: NnrU; pfam07298 573065004159 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573065004160 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573065004161 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 573065004162 hypothetical protein; Provisional; Region: PRK02237 573065004163 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573065004164 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 573065004165 cation binding site [ion binding]; other site 573065004166 HAMP domain; Region: HAMP; pfam00672 573065004167 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065004168 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065004169 dimer interface [polypeptide binding]; other site 573065004170 putative CheW interface [polypeptide binding]; other site 573065004171 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 573065004172 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 573065004173 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 573065004174 glutathione reductase; Validated; Region: PRK06116 573065004175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573065004176 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573065004177 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 573065004178 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573065004179 active site 573065004180 dimer interface [polypeptide binding]; other site 573065004181 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 573065004182 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 573065004183 Substrate binding site; other site 573065004184 Mg++ binding site; other site 573065004185 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 573065004186 active site 573065004187 substrate binding site [chemical binding]; other site 573065004188 CoA binding site [chemical binding]; other site 573065004189 phosphoglycolate phosphatase; Provisional; Region: PRK13222 573065004190 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573065004191 motif II; other site 573065004192 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 573065004193 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 573065004194 TrkA-N domain; Region: TrkA_N; pfam02254 573065004195 N-formylglutamate amidohydrolase; Region: FGase; cl01522 573065004196 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 573065004197 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 573065004198 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 573065004199 homodimer interface [polypeptide binding]; other site 573065004200 NADP binding site [chemical binding]; other site 573065004201 substrate binding site [chemical binding]; other site 573065004202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 573065004203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573065004204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573065004205 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 573065004206 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 573065004207 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573065004208 CoenzymeA binding site [chemical binding]; other site 573065004209 subunit interaction site [polypeptide binding]; other site 573065004210 PHB binding site; other site 573065004211 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 573065004212 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 573065004213 Permease; Region: Permease; pfam02405 573065004214 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 573065004215 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 573065004216 Walker A/P-loop; other site 573065004217 ATP binding site [chemical binding]; other site 573065004218 Q-loop/lid; other site 573065004219 ABC transporter signature motif; other site 573065004220 Walker B; other site 573065004221 D-loop; other site 573065004222 H-loop/switch region; other site 573065004223 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 573065004224 mce related protein; Region: MCE; pfam02470 573065004225 Protein of unknown function (DUF330); Region: DUF330; cl01135 573065004226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 573065004227 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 573065004228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065004229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065004230 ATP binding site [chemical binding]; other site 573065004231 Mg2+ binding site [ion binding]; other site 573065004232 G-X-G motif; other site 573065004233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 573065004234 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573065004235 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573065004236 catalytic residue [active] 573065004237 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 573065004238 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 573065004239 Gram-negative bacterial tonB protein; Region: TonB; cl10048 573065004240 Peptidase family M48; Region: Peptidase_M48; pfam01435 573065004241 Gram-negative bacterial tonB protein; Region: TonB; cl10048 573065004242 Gram-negative bacterial tonB protein; Region: TonB; cl10048 573065004243 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 573065004244 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 573065004245 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 573065004246 Transglycosylase SLT domain; Region: SLT_2; pfam13406 573065004247 murein hydrolase B; Provisional; Region: PRK10760; cl17906 573065004248 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573065004249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065004250 dimerization interface [polypeptide binding]; other site 573065004251 putative DNA binding site [nucleotide binding]; other site 573065004252 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573065004253 putative Zn2+ binding site [ion binding]; other site 573065004254 Transcriptional regulator PadR-like family; Region: PadR; cl17335 573065004255 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 573065004256 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573065004257 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 573065004258 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 573065004259 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 573065004260 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573065004261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065004262 active site 573065004263 phosphorylation site [posttranslational modification] 573065004264 intermolecular recognition site; other site 573065004265 dimerization interface [polypeptide binding]; other site 573065004266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065004267 Walker A motif; other site 573065004268 ATP binding site [chemical binding]; other site 573065004269 Walker B motif; other site 573065004270 arginine finger; other site 573065004271 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573065004272 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 573065004273 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 573065004274 active site 573065004275 Zn binding site [ion binding]; other site 573065004276 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 573065004277 Uncharacterized conserved protein [Function unknown]; Region: COG1284 573065004278 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573065004279 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573065004280 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 573065004281 Protein of unknown function (DUF817); Region: DUF817; pfam05675 573065004282 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 573065004283 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 573065004284 ligand binding site [chemical binding]; other site 573065004285 homodimer interface [polypeptide binding]; other site 573065004286 NAD(P) binding site [chemical binding]; other site 573065004287 trimer interface B [polypeptide binding]; other site 573065004288 trimer interface A [polypeptide binding]; other site 573065004289 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 573065004290 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 573065004291 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 573065004292 putative transposase OrfB; Reviewed; Region: PHA02517 573065004293 HTH-like domain; Region: HTH_21; pfam13276 573065004294 Integrase core domain; Region: rve; pfam00665 573065004295 Integrase core domain; Region: rve_2; pfam13333 573065004296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573065004297 Helix-turn-helix domain; Region: HTH_28; pfam13518 573065004298 Helix-turn-helix domain; Region: HTH_28; pfam13518 573065004299 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 573065004300 glycine dehydrogenase; Provisional; Region: PRK05367 573065004301 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 573065004302 tetramer interface [polypeptide binding]; other site 573065004303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065004304 catalytic residue [active] 573065004305 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 573065004306 tetramer interface [polypeptide binding]; other site 573065004307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065004308 catalytic residue [active] 573065004309 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 573065004310 lipoyl attachment site [posttranslational modification]; other site 573065004311 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 573065004312 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 573065004313 LabA_like proteins; Region: LabA_like; cd06167 573065004314 putative metal binding site [ion binding]; other site 573065004315 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 573065004316 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 573065004317 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 573065004318 RNA/DNA hybrid binding site [nucleotide binding]; other site 573065004319 active site 573065004320 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 573065004321 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065004322 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065004323 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 573065004324 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 573065004325 trimer interface [polypeptide binding]; other site 573065004326 putative metal binding site [ion binding]; other site 573065004327 PhoH-like protein; Region: PhoH; pfam02562 573065004328 Predicted chitinase [General function prediction only]; Region: COG3179 573065004329 Peptidase M15; Region: Peptidase_M15_3; cl01194 573065004330 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 573065004331 ATP-NAD kinase; Region: NAD_kinase; pfam01513 573065004332 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 573065004333 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 573065004334 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 573065004335 Nucleoside recognition; Region: Gate; pfam07670 573065004336 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 573065004337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573065004338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065004339 active site 573065004340 phosphorylation site [posttranslational modification] 573065004341 intermolecular recognition site; other site 573065004342 dimerization interface [polypeptide binding]; other site 573065004343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065004344 DNA binding site [nucleotide binding] 573065004345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065004346 HAMP domain; Region: HAMP; pfam00672 573065004347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065004348 dimer interface [polypeptide binding]; other site 573065004349 phosphorylation site [posttranslational modification] 573065004350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065004351 ATP binding site [chemical binding]; other site 573065004352 Mg2+ binding site [ion binding]; other site 573065004353 G-X-G motif; other site 573065004354 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 573065004355 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 573065004356 Predicted membrane protein [Function unknown]; Region: COG4709 573065004357 Predicted transcriptional regulators [Transcription]; Region: COG1695 573065004358 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573065004359 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 573065004360 UbiA prenyltransferase family; Region: UbiA; pfam01040 573065004361 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 573065004362 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 573065004363 Predicted methyltransferase [General function prediction only]; Region: COG3897 573065004364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065004365 S-adenosylmethionine binding site [chemical binding]; other site 573065004366 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573065004367 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 573065004368 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 573065004369 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573065004370 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573065004371 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573065004372 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573065004373 transcriptional repressor DicA; Reviewed; Region: PRK09706 573065004374 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065004375 sequence-specific DNA binding site [nucleotide binding]; other site 573065004376 salt bridge; other site 573065004377 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 573065004378 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 573065004379 active site 573065004380 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 573065004381 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573065004382 Predicted methyltransferase [General function prediction only]; Region: COG4798 573065004383 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573065004384 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 573065004385 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 573065004386 heme binding site [chemical binding]; other site 573065004387 ferroxidase pore; other site 573065004388 ferroxidase diiron center [ion binding]; other site 573065004389 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 573065004390 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 573065004391 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573065004392 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573065004393 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 573065004394 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573065004395 active site residue [active] 573065004396 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065004397 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065004398 N-terminal plug; other site 573065004399 ligand-binding site [chemical binding]; other site 573065004400 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 573065004401 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 573065004402 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 573065004403 GIY-YIG motif/motif A; other site 573065004404 active site 573065004405 catalytic site [active] 573065004406 putative DNA binding site [nucleotide binding]; other site 573065004407 metal binding site [ion binding]; metal-binding site 573065004408 UvrB/uvrC motif; Region: UVR; pfam02151 573065004409 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 573065004410 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573065004411 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 573065004412 nudix motif; other site 573065004413 short chain dehydrogenase; Provisional; Region: PRK09134 573065004414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065004415 NAD(P) binding site [chemical binding]; other site 573065004416 active site 573065004417 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 573065004418 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573065004419 substrate binding pocket [chemical binding]; other site 573065004420 chain length determination region; other site 573065004421 substrate-Mg2+ binding site; other site 573065004422 catalytic residues [active] 573065004423 aspartate-rich region 1; other site 573065004424 active site lid residues [active] 573065004425 aspartate-rich region 2; other site 573065004426 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 573065004427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065004428 S-adenosylmethionine binding site [chemical binding]; other site 573065004429 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 573065004430 Clp amino terminal domain; Region: Clp_N; pfam02861 573065004431 Clp amino terminal domain; Region: Clp_N; pfam02861 573065004432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065004433 Walker A motif; other site 573065004434 ATP binding site [chemical binding]; other site 573065004435 Walker B motif; other site 573065004436 arginine finger; other site 573065004437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065004438 Walker A motif; other site 573065004439 ATP binding site [chemical binding]; other site 573065004440 Walker B motif; other site 573065004441 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573065004442 MarR family; Region: MarR_2; pfam12802 573065004443 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 573065004444 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 573065004445 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 573065004446 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 573065004447 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 573065004448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065004449 putative ADP-binding pocket [chemical binding]; other site 573065004450 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573065004451 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065004452 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 573065004453 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 573065004454 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 573065004455 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573065004456 putative NAD(P) binding site [chemical binding]; other site 573065004457 DNA polymerase IV; Reviewed; Region: PRK03103 573065004458 Y-family of DNA polymerases; Region: PolY; cd00424 573065004459 active site 573065004460 DNA binding site [nucleotide binding] 573065004461 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 573065004462 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 573065004463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065004464 putative substrate translocation pore; other site 573065004465 HAMP domain; Region: HAMP; pfam00672 573065004466 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065004467 dimer interface [polypeptide binding]; other site 573065004468 putative CheW interface [polypeptide binding]; other site 573065004469 Leucine rich repeat; Region: LRR_8; pfam13855 573065004470 Leucine rich repeat; Region: LRR_8; pfam13855 573065004471 Leucine rich repeat; Region: LRR_8; pfam13855 573065004472 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 573065004473 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573065004474 active site 573065004475 ATP binding site [chemical binding]; other site 573065004476 substrate binding site [chemical binding]; other site 573065004477 activation loop (A-loop); other site 573065004478 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 573065004479 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 573065004480 NAD-dependent deacetylase; Provisional; Region: PRK00481 573065004481 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 573065004482 NAD+ binding site [chemical binding]; other site 573065004483 substrate binding site [chemical binding]; other site 573065004484 Zn binding site [ion binding]; other site 573065004485 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 573065004486 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 573065004487 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573065004488 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573065004489 rod shape-determining protein MreC; Provisional; Region: PRK13922 573065004490 rod shape-determining protein MreC; Region: MreC; pfam04085 573065004491 rod shape-determining protein MreB; Provisional; Region: PRK13927 573065004492 MreB and similar proteins; Region: MreB_like; cd10225 573065004493 nucleotide binding site [chemical binding]; other site 573065004494 Mg binding site [ion binding]; other site 573065004495 putative protofilament interaction site [polypeptide binding]; other site 573065004496 RodZ interaction site [polypeptide binding]; other site 573065004497 Uncharacterized conserved protein [Function unknown]; Region: COG0398 573065004498 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573065004499 hypothetical protein; Validated; Region: PRK00110 573065004500 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 573065004501 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 573065004502 putative active site [active] 573065004503 metal binding site [ion binding]; metal-binding site 573065004504 homodimer binding site [polypeptide binding]; other site 573065004505 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 573065004506 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 573065004507 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 573065004508 Probable beta-xylosidase; Provisional; Region: PLN03080 573065004509 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573065004510 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573065004511 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 573065004512 active site 573065004513 metal binding site [ion binding]; metal-binding site 573065004514 Cell division protein ZapA; Region: ZapA; cl01146 573065004515 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 573065004516 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 573065004517 TPP-binding site [chemical binding]; other site 573065004518 dimer interface [polypeptide binding]; other site 573065004519 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573065004520 PYR/PP interface [polypeptide binding]; other site 573065004521 dimer interface [polypeptide binding]; other site 573065004522 TPP binding site [chemical binding]; other site 573065004523 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573065004524 DNA-binding site [nucleotide binding]; DNA binding site 573065004525 RNA-binding motif; other site 573065004526 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 573065004527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065004528 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 573065004529 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 573065004530 active site 573065004531 uracil binding [chemical binding]; other site 573065004532 EF hand; Region: EF_hand_3; pfam13202 573065004533 EF-hand domain pair; Region: EF_hand_5; pfam13499 573065004534 Ca2+ binding site [ion binding]; other site 573065004535 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 573065004536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065004537 active site 573065004538 phosphorylation site [posttranslational modification] 573065004539 intermolecular recognition site; other site 573065004540 dimerization interface [polypeptide binding]; other site 573065004541 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065004542 DNA binding site [nucleotide binding] 573065004543 HAMP domain; Region: HAMP; pfam00672 573065004544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065004545 dimer interface [polypeptide binding]; other site 573065004546 phosphorylation site [posttranslational modification] 573065004547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065004548 ATP binding site [chemical binding]; other site 573065004549 Mg2+ binding site [ion binding]; other site 573065004550 G-X-G motif; other site 573065004551 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 573065004552 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 573065004553 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 573065004554 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 573065004555 Phosphoglycerate kinase; Region: PGK; pfam00162 573065004556 substrate binding site [chemical binding]; other site 573065004557 hinge regions; other site 573065004558 ADP binding site [chemical binding]; other site 573065004559 catalytic site [active] 573065004560 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573065004561 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 573065004562 intersubunit interface [polypeptide binding]; other site 573065004563 active site 573065004564 zinc binding site [ion binding]; other site 573065004565 Na+ binding site [ion binding]; other site 573065004566 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573065004567 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 573065004568 putative dimer interface [polypeptide binding]; other site 573065004569 Predicted transcriptional regulator [Transcription]; Region: COG2378 573065004570 HTH domain; Region: HTH_11; pfam08279 573065004571 WYL domain; Region: WYL; pfam13280 573065004572 cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324 573065004573 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573065004574 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573065004575 catalytic residue [active] 573065004576 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 573065004577 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 573065004578 sulfate transport protein; Provisional; Region: cysT; CHL00187 573065004579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065004580 dimer interface [polypeptide binding]; other site 573065004581 conserved gate region; other site 573065004582 putative PBP binding loops; other site 573065004583 ABC-ATPase subunit interface; other site 573065004584 sulfate transport protein; Provisional; Region: cysT; CHL00187 573065004585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065004586 dimer interface [polypeptide binding]; other site 573065004587 conserved gate region; other site 573065004588 putative PBP binding loops; other site 573065004589 ABC-ATPase subunit interface; other site 573065004590 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 573065004591 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 573065004592 Walker A/P-loop; other site 573065004593 ATP binding site [chemical binding]; other site 573065004594 Q-loop/lid; other site 573065004595 ABC transporter signature motif; other site 573065004596 Walker B; other site 573065004597 D-loop; other site 573065004598 H-loop/switch region; other site 573065004599 TOBE-like domain; Region: TOBE_3; pfam12857 573065004600 short chain dehydrogenase; Validated; Region: PRK08264 573065004601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065004602 NAD(P) binding site [chemical binding]; other site 573065004603 active site 573065004604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065004605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065004606 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 573065004607 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065004608 N-terminal plug; other site 573065004609 ligand-binding site [chemical binding]; other site 573065004610 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 573065004611 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 573065004612 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 573065004613 active site 573065004614 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 573065004615 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 573065004616 nucleotide binding pocket [chemical binding]; other site 573065004617 K-X-D-G motif; other site 573065004618 catalytic site [active] 573065004619 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 573065004620 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 573065004621 Dimer interface [polypeptide binding]; other site 573065004622 BRCT sequence motif; other site 573065004623 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 573065004624 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573065004625 Walker A/P-loop; other site 573065004626 ATP binding site [chemical binding]; other site 573065004627 Q-loop/lid; other site 573065004628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065004629 Q-loop/lid; other site 573065004630 ABC transporter signature motif; other site 573065004631 Walker B; other site 573065004632 D-loop; other site 573065004633 H-loop/switch region; other site 573065004634 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 573065004635 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 573065004636 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 573065004637 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 573065004638 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 573065004639 nucleotide binding site [chemical binding]; other site 573065004640 SulA interaction site; other site 573065004641 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 573065004642 Cell division protein FtsA; Region: FtsA; smart00842 573065004643 Cell division protein FtsA; Region: FtsA; pfam14450 573065004644 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 573065004645 Cell division protein FtsQ; Region: FtsQ; pfam03799 573065004646 FtsH Extracellular; Region: FtsH_ext; pfam06480 573065004647 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 573065004648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065004649 Walker A motif; other site 573065004650 ATP binding site [chemical binding]; other site 573065004651 Walker B motif; other site 573065004652 arginine finger; other site 573065004653 Peptidase family M41; Region: Peptidase_M41; pfam01434 573065004654 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 573065004655 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 573065004656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 573065004657 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573065004658 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573065004659 ligand binding site [chemical binding]; other site 573065004660 translocation protein TolB; Provisional; Region: tolB; PRK05137 573065004661 TolB amino-terminal domain; Region: TolB_N; pfam04052 573065004662 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573065004663 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573065004664 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573065004665 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573065004666 Gram-negative bacterial tonB protein; Region: TonB; cl10048 573065004667 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 573065004668 TolR protein; Region: tolR; TIGR02801 573065004669 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 573065004670 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 573065004671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065004672 Walker A motif; other site 573065004673 ATP binding site [chemical binding]; other site 573065004674 Walker B motif; other site 573065004675 arginine finger; other site 573065004676 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 573065004677 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 573065004678 RuvA N terminal domain; Region: RuvA_N; pfam01330 573065004679 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 573065004680 active site 573065004681 putative DNA-binding cleft [nucleotide binding]; other site 573065004682 dimer interface [polypeptide binding]; other site 573065004683 Protein of unknown function, DUF486; Region: DUF486; cl01236 573065004684 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 573065004685 Surface antigen; Region: Bac_surface_Ag; pfam01103 573065004686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 573065004687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 573065004688 Family of unknown function (DUF490); Region: DUF490; pfam04357 573065004689 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573065004690 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573065004691 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573065004692 ABC transporter; Region: ABC_tran_2; pfam12848 573065004693 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573065004694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065004695 PAS domain; Region: PAS_9; pfam13426 573065004696 putative active site [active] 573065004697 heme pocket [chemical binding]; other site 573065004698 GAF domain; Region: GAF_2; pfam13185 573065004699 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573065004700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573065004701 metal binding site [ion binding]; metal-binding site 573065004702 active site 573065004703 I-site; other site 573065004704 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573065004705 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573065004706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065004707 DNA-binding site [nucleotide binding]; DNA binding site 573065004708 UTRA domain; Region: UTRA; pfam07702 573065004709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 573065004710 L-fucose transporter; Provisional; Region: PRK10133; cl17665 573065004711 glucose/galactose transporter; Region: gluP; TIGR01272 573065004712 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573065004713 nucleotide binding site [chemical binding]; other site 573065004714 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 573065004715 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 573065004716 active site 573065004717 dimer interface [polypeptide binding]; other site 573065004718 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573065004719 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573065004720 ligand binding site [chemical binding]; other site 573065004721 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573065004722 active site 573065004723 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 573065004724 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 573065004725 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 573065004726 Flavoprotein; Region: Flavoprotein; pfam02441 573065004727 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 573065004728 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573065004729 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573065004730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 573065004731 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 573065004732 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 573065004733 NAD(P) binding site [chemical binding]; other site 573065004734 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 573065004735 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 573065004736 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 573065004737 thiamine phosphate binding site [chemical binding]; other site 573065004738 active site 573065004739 pyrophosphate binding site [ion binding]; other site 573065004740 elongation factor P; Validated; Region: PRK00529 573065004741 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 573065004742 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 573065004743 RNA binding site [nucleotide binding]; other site 573065004744 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 573065004745 RNA binding site [nucleotide binding]; other site 573065004746 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 573065004747 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 573065004748 active site 573065004749 dimerization interface [polypeptide binding]; other site 573065004750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065004751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065004752 short chain dehydrogenase; Provisional; Region: PRK06180 573065004753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065004754 NAD(P) binding site [chemical binding]; other site 573065004755 active site 573065004756 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 573065004757 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573065004758 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 573065004759 Walker A/P-loop; other site 573065004760 ATP binding site [chemical binding]; other site 573065004761 Q-loop/lid; other site 573065004762 ABC transporter signature motif; other site 573065004763 Walker B; other site 573065004764 D-loop; other site 573065004765 H-loop/switch region; other site 573065004766 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 573065004767 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 573065004768 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573065004769 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 573065004770 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 573065004771 feedback inhibition sensing region; other site 573065004772 homohexameric interface [polypeptide binding]; other site 573065004773 carbamate kinase; Reviewed; Region: PRK12686 573065004774 nucleotide binding site [chemical binding]; other site 573065004775 N-acetyl-L-glutamate binding site [chemical binding]; other site 573065004776 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 573065004777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 573065004778 motif II; other site 573065004779 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 573065004780 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 573065004781 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 573065004782 trimer interface [polypeptide binding]; other site 573065004783 active site 573065004784 substrate binding site [chemical binding]; other site 573065004785 CoA binding site [chemical binding]; other site 573065004786 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 573065004787 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 573065004788 ketol-acid reductoisomerase; Provisional; Region: PRK05479 573065004789 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 573065004790 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 573065004791 thymidylate synthase; Reviewed; Region: thyA; PRK01827 573065004792 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 573065004793 dimerization interface [polypeptide binding]; other site 573065004794 active site 573065004795 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 573065004796 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 573065004797 folate binding site [chemical binding]; other site 573065004798 NADP+ binding site [chemical binding]; other site 573065004799 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 573065004800 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 573065004801 putative active site [active] 573065004802 putative FMN binding site [chemical binding]; other site 573065004803 putative substrate binding site [chemical binding]; other site 573065004804 putative catalytic residue [active] 573065004805 Predicted membrane protein [Function unknown]; Region: COG3503 573065004806 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 573065004807 RelB antitoxin; Region: RelB; cl01171 573065004808 Domain of unknown function DUF59; Region: DUF59; pfam01883 573065004809 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 573065004810 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 573065004811 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 573065004812 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 573065004813 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573065004814 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065004815 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 573065004816 active site 573065004817 catalytic residues [active] 573065004818 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 573065004819 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573065004820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 573065004821 GAF domain; Region: GAF; pfam01590 573065004822 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 573065004823 DNA-binding interface [nucleotide binding]; DNA binding site 573065004824 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 573065004825 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 573065004826 NAD(P) binding site [chemical binding]; other site 573065004827 catalytic residues [active] 573065004828 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 573065004829 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 573065004830 NAD binding site [chemical binding]; other site 573065004831 substrate binding site [chemical binding]; other site 573065004832 catalytic Zn binding site [ion binding]; other site 573065004833 tetramer interface [polypeptide binding]; other site 573065004834 structural Zn binding site [ion binding]; other site 573065004835 Stringent starvation protein B; Region: SspB; cl01120 573065004836 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573065004837 Beta-lactamase; Region: Beta-lactamase; pfam00144 573065004838 Endodeoxyribonuclease RusA; Region: RusA; cl01885 573065004839 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 573065004840 active site 573065004841 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 573065004842 Part of AAA domain; Region: AAA_19; pfam13245 573065004843 Family description; Region: UvrD_C_2; pfam13538 573065004844 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 573065004845 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 573065004846 hypothetical protein; Provisional; Region: PRK11770 573065004847 Domain of unknown function (DUF307); Region: DUF307; pfam03733 573065004848 Domain of unknown function (DUF307); Region: DUF307; pfam03733 573065004849 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573065004850 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 573065004851 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065004852 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 573065004853 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573065004854 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 573065004855 Probable Catalytic site; other site 573065004856 metal-binding site 573065004857 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 573065004858 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 573065004859 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573065004860 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 573065004861 active site 573065004862 dimer interface [polypeptide binding]; other site 573065004863 motif 1; other site 573065004864 motif 2; other site 573065004865 motif 3; other site 573065004866 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 573065004867 anticodon binding site; other site 573065004868 Haemolytic domain; Region: Haemolytic; cl00506 573065004869 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 573065004870 trimerization site [polypeptide binding]; other site 573065004871 active site 573065004872 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 573065004873 putative hydrophobic ligand binding site [chemical binding]; other site 573065004874 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 573065004875 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573065004876 active site 573065004877 HIGH motif; other site 573065004878 nucleotide binding site [chemical binding]; other site 573065004879 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 573065004880 KMSKS motif; other site 573065004881 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573065004882 tRNA binding surface [nucleotide binding]; other site 573065004883 anticodon binding site; other site 573065004884 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 573065004885 active site 573065004886 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 573065004887 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 573065004888 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 573065004889 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573065004890 active site 573065004891 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 573065004892 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573065004893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065004894 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 573065004895 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065004896 DNA binding residues [nucleotide binding] 573065004897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573065004898 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 573065004899 catalytic motif [active] 573065004900 Catalytic residue [active] 573065004901 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 573065004902 catalytic motif [active] 573065004903 Catalytic residue [active] 573065004904 Response regulator receiver domain; Region: Response_reg; pfam00072 573065004905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065004906 active site 573065004907 phosphorylation site [posttranslational modification] 573065004908 intermolecular recognition site; other site 573065004909 dimerization interface [polypeptide binding]; other site 573065004910 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 573065004911 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 573065004912 GDP-binding site [chemical binding]; other site 573065004913 ACT binding site; other site 573065004914 IMP binding site; other site 573065004915 phosphoserine aminotransferase; Provisional; Region: PRK03080 573065004916 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573065004917 catalytic residue [active] 573065004918 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 573065004919 dimer interface [polypeptide binding]; other site 573065004920 substrate binding site [chemical binding]; other site 573065004921 ATP binding site [chemical binding]; other site 573065004922 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 573065004923 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 573065004924 dihydropteroate synthase; Region: DHPS; TIGR01496 573065004925 substrate binding pocket [chemical binding]; other site 573065004926 dimer interface [polypeptide binding]; other site 573065004927 inhibitor binding site; inhibition site 573065004928 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 573065004929 FAD binding domain; Region: FAD_binding_4; pfam01565 573065004930 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 573065004931 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 573065004932 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573065004933 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573065004934 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573065004935 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 573065004936 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 573065004937 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573065004938 Domain of unknown function DUF20; Region: UPF0118; pfam01594 573065004939 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 573065004940 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 573065004941 active site 573065004942 homodimer interface [polypeptide binding]; other site 573065004943 cell division protein FtsW; Region: ftsW; TIGR02614 573065004944 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 573065004945 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 573065004946 23S rRNA binding site [nucleotide binding]; other site 573065004947 L21 binding site [polypeptide binding]; other site 573065004948 L13 binding site [polypeptide binding]; other site 573065004949 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 573065004950 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573065004951 aminotransferase; Validated; Region: PRK07046 573065004952 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573065004953 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573065004954 catalytic residue [active] 573065004955 succinic semialdehyde dehydrogenase; Region: PLN02278 573065004956 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 573065004957 tetramerization interface [polypeptide binding]; other site 573065004958 NAD(P) binding site [chemical binding]; other site 573065004959 catalytic residues [active] 573065004960 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 573065004961 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 573065004962 NAD(P) binding site [chemical binding]; other site 573065004963 catalytic residues [active] 573065004964 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 573065004965 Transcriptional regulators [Transcription]; Region: GntR; COG1802 573065004966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065004967 DNA-binding site [nucleotide binding]; DNA binding site 573065004968 FCD domain; Region: FCD; pfam07729 573065004969 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 573065004970 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573065004971 inhibitor-cofactor binding pocket; inhibition site 573065004972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065004973 catalytic residue [active] 573065004974 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 573065004975 putative metal binding site [ion binding]; other site 573065004976 putative homodimer interface [polypeptide binding]; other site 573065004977 putative homotetramer interface [polypeptide binding]; other site 573065004978 putative homodimer-homodimer interface [polypeptide binding]; other site 573065004979 putative allosteric switch controlling residues; other site 573065004980 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 573065004981 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 573065004982 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 573065004983 EF-hand domain pair; Region: EF_hand_5; pfam13499 573065004984 Ca2+ binding site [ion binding]; other site 573065004985 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 573065004986 Ca2+ binding site [ion binding]; other site 573065004987 RNA polymerase sigma factor; Reviewed; Region: PRK05602 573065004988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065004989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065004990 DNA binding residues [nucleotide binding] 573065004991 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 573065004992 pseudo EF-hand loop; other site 573065004993 Ca2+ binding site [ion binding]; other site 573065004994 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573065004995 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065004996 putative DNA binding site [nucleotide binding]; other site 573065004997 putative Zn2+ binding site [ion binding]; other site 573065004998 AsnC family; Region: AsnC_trans_reg; pfam01037 573065004999 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 573065005000 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 573065005001 hexamer interface [polypeptide binding]; other site 573065005002 ligand binding site [chemical binding]; other site 573065005003 putative active site [active] 573065005004 NAD(P) binding site [chemical binding]; other site 573065005005 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 573065005006 nucleophilic elbow; other site 573065005007 catalytic triad; other site 573065005008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573065005009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065005010 Coenzyme A binding pocket [chemical binding]; other site 573065005011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065005012 Coenzyme A binding pocket [chemical binding]; other site 573065005013 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 573065005014 Sel1-like repeats; Region: SEL1; smart00671 573065005015 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573065005016 Sel1-like repeats; Region: SEL1; smart00671 573065005017 Sel1-like repeats; Region: SEL1; smart00671 573065005018 Sel1-like repeats; Region: SEL1; smart00671 573065005019 LemA family; Region: LemA; cl00742 573065005020 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 573065005021 Repair protein; Region: Repair_PSII; pfam04536 573065005022 Repair protein; Region: Repair_PSII; cl01535 573065005023 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 573065005024 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 573065005025 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 573065005026 dimer interface [polypeptide binding]; other site 573065005027 motif 1; other site 573065005028 active site 573065005029 motif 2; other site 573065005030 motif 3; other site 573065005031 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 573065005032 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 573065005033 putative tRNA-binding site [nucleotide binding]; other site 573065005034 B3/4 domain; Region: B3_4; pfam03483 573065005035 tRNA synthetase B5 domain; Region: B5; smart00874 573065005036 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 573065005037 dimer interface [polypeptide binding]; other site 573065005038 motif 1; other site 573065005039 motif 3; other site 573065005040 motif 2; other site 573065005041 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 573065005042 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 573065005043 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 573065005044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065005045 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 573065005046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065005047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065005048 dimer interface [polypeptide binding]; other site 573065005049 phosphorylation site [posttranslational modification] 573065005050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065005051 ATP binding site [chemical binding]; other site 573065005052 Mg2+ binding site [ion binding]; other site 573065005053 G-X-G motif; other site 573065005054 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 573065005055 Ribonuclease P; Region: Ribonuclease_P; cl00457 573065005056 membrane protein insertase; Provisional; Region: PRK01318 573065005057 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 573065005058 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 573065005059 G1 box; other site 573065005060 GTP/Mg2+ binding site [chemical binding]; other site 573065005061 Switch I region; other site 573065005062 G2 box; other site 573065005063 G3 box; other site 573065005064 Switch II region; other site 573065005065 G4 box; other site 573065005066 G5 box; other site 573065005067 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 573065005068 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 573065005069 serine acetyltransferase; Provisional; Region: cysE; PRK11132 573065005070 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 573065005071 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 573065005072 trimer interface [polypeptide binding]; other site 573065005073 active site 573065005074 substrate binding site [chemical binding]; other site 573065005075 CoA binding site [chemical binding]; other site 573065005076 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 573065005077 dimer interface [polypeptide binding]; other site 573065005078 ADP-ribose binding site [chemical binding]; other site 573065005079 active site 573065005080 nudix motif; other site 573065005081 metal binding site [ion binding]; metal-binding site 573065005082 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 573065005083 putative FMN binding site [chemical binding]; other site 573065005084 Mitochondrial import protein Pam17; Region: Pam17; pfam08566 573065005085 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 573065005086 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 573065005087 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 573065005088 FMN binding site [chemical binding]; other site 573065005089 substrate binding site [chemical binding]; other site 573065005090 putative catalytic residue [active] 573065005091 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 573065005092 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 573065005093 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 573065005094 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573065005095 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 573065005096 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 573065005097 Mg++ binding site [ion binding]; other site 573065005098 putative catalytic motif [active] 573065005099 putative substrate binding site [chemical binding]; other site 573065005100 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 573065005101 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573065005102 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573065005103 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573065005104 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 573065005105 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573065005106 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573065005107 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573065005108 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 573065005109 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573065005110 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573065005111 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 573065005112 MraW methylase family; Region: Methyltransf_5; cl17771 573065005113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 573065005114 MraZ protein; Region: MraZ; pfam02381 573065005115 MraZ protein; Region: MraZ; pfam02381 573065005116 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 573065005117 Protein of unknown function (DUF423); Region: DUF423; cl01008 573065005118 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 573065005119 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 573065005120 amidase catalytic site [active] 573065005121 Zn binding residues [ion binding]; other site 573065005122 substrate binding site [chemical binding]; other site 573065005123 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573065005124 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 573065005125 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 573065005126 putative metal binding site [ion binding]; other site 573065005127 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 573065005128 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 573065005129 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 573065005130 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 573065005131 active site 573065005132 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 573065005133 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 573065005134 substrate binding pocket [chemical binding]; other site 573065005135 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 573065005136 B12 binding site [chemical binding]; other site 573065005137 cobalt ligand [ion binding]; other site 573065005138 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 573065005139 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 573065005140 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 573065005141 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573065005142 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 573065005143 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 573065005144 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573065005145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065005146 S-adenosylmethionine binding site [chemical binding]; other site 573065005147 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 573065005148 FAD binding site [chemical binding]; other site 573065005149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065005150 dimerization interface [polypeptide binding]; other site 573065005151 putative DNA binding site [nucleotide binding]; other site 573065005152 putative Zn2+ binding site [ion binding]; other site 573065005153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065005154 S-adenosylmethionine binding site [chemical binding]; other site 573065005155 Protein of unknown function (DUF983); Region: DUF983; cl02211 573065005156 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 573065005157 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 573065005158 dimer interface [polypeptide binding]; other site 573065005159 substrate binding site [chemical binding]; other site 573065005160 metal binding sites [ion binding]; metal-binding site 573065005161 Protein of unknown function, DUF599; Region: DUF599; cl01575 573065005162 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 573065005163 Response regulator receiver domain; Region: Response_reg; pfam00072 573065005164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065005165 active site 573065005166 phosphorylation site [posttranslational modification] 573065005167 intermolecular recognition site; other site 573065005168 dimerization interface [polypeptide binding]; other site 573065005169 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 573065005170 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 573065005171 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 573065005172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573065005173 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 573065005174 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 573065005175 nudix motif; other site 573065005176 Rrf2 family protein; Region: rrf2_super; TIGR00738 573065005177 Transcriptional regulator; Region: Rrf2; pfam02082 573065005178 Transcriptional regulator; Region: Rrf2; cl17282 573065005179 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 573065005180 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 573065005181 nucleophile elbow; other site 573065005182 Patatin phospholipase; Region: DUF3734; pfam12536 573065005183 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 573065005184 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 573065005185 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573065005186 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 573065005187 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 573065005188 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573065005189 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 573065005190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 573065005191 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 573065005192 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 573065005193 putative dimer interface [polypeptide binding]; other site 573065005194 putative active site [active] 573065005195 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 573065005196 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 573065005197 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573065005198 Uncharacterized conserved protein [Function unknown]; Region: COG2308 573065005199 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 573065005200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 573065005201 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 573065005202 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573065005203 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573065005204 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573065005205 nucleotide binding site [chemical binding]; other site 573065005206 Carboxylesterase family; Region: COesterase; pfam00135 573065005207 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573065005208 substrate binding pocket [chemical binding]; other site 573065005209 catalytic triad [active] 573065005210 fructokinase; Reviewed; Region: PRK09557 573065005211 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573065005212 nucleotide binding site [chemical binding]; other site 573065005213 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 573065005214 L-fucose transporter; Provisional; Region: PRK10133; cl17665 573065005215 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065005216 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065005217 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065005218 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065005219 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065005220 pyruvate kinase; Provisional; Region: PRK06247 573065005221 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 573065005222 domain interfaces; other site 573065005223 active site 573065005224 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 573065005225 active site 573065005226 catalytic motif [active] 573065005227 Zn binding site [ion binding]; other site 573065005228 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573065005229 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573065005230 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 573065005231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065005232 putative substrate translocation pore; other site 573065005233 Amidohydrolase; Region: Amidohydro_2; pfam04909 573065005234 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 573065005235 active site 573065005236 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573065005237 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573065005238 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573065005239 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573065005240 active site 573065005241 catalytic tetrad [active] 573065005242 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 573065005243 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 573065005244 short chain dehydrogenase; Provisional; Region: PRK06138 573065005245 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 573065005246 NAD binding site [chemical binding]; other site 573065005247 homotetramer interface [polypeptide binding]; other site 573065005248 homodimer interface [polypeptide binding]; other site 573065005249 active site 573065005250 Cupin domain; Region: Cupin_2; pfam07883 573065005251 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 573065005252 active site 573065005253 catalytic residues [active] 573065005254 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 573065005255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065005256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065005257 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 573065005258 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 573065005259 Strictosidine synthase; Region: Str_synth; pfam03088 573065005260 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 573065005261 classical (c) SDRs; Region: SDR_c; cd05233 573065005262 NAD(P) binding site [chemical binding]; other site 573065005263 active site 573065005264 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 573065005265 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 573065005266 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065005267 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065005268 DNA binding site [nucleotide binding] 573065005269 domain linker motif; other site 573065005270 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 573065005271 putative dimerization interface [polypeptide binding]; other site 573065005272 putative ligand binding site [chemical binding]; other site 573065005273 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573065005274 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065005275 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573065005276 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 573065005277 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 573065005278 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 573065005279 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 573065005280 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 573065005281 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 573065005282 catalytic site [active] 573065005283 subunit interface [polypeptide binding]; other site 573065005284 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 573065005285 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573065005286 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 573065005287 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 573065005288 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573065005289 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573065005290 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 573065005291 IMP binding site; other site 573065005292 dimer interface [polypeptide binding]; other site 573065005293 partial ornithine binding site; other site 573065005294 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 573065005295 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573065005296 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 573065005297 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065005298 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 573065005299 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573065005300 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573065005301 Bacterial transcriptional regulator; Region: IclR; pfam01614 573065005302 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 573065005303 active site 573065005304 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 573065005305 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065005306 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065005307 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065005308 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 573065005309 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 573065005310 classical (c) SDRs; Region: SDR_c; cd05233 573065005311 NAD(P) binding site [chemical binding]; other site 573065005312 active site 573065005313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065005314 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 573065005315 Walker A/P-loop; other site 573065005316 ATP binding site [chemical binding]; other site 573065005317 Q-loop/lid; other site 573065005318 ABC transporter signature motif; other site 573065005319 Walker B; other site 573065005320 D-loop; other site 573065005321 H-loop/switch region; other site 573065005322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065005323 putative PBP binding loops; other site 573065005324 dimer interface [polypeptide binding]; other site 573065005325 ABC-ATPase subunit interface; other site 573065005326 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 573065005327 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573065005328 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 573065005329 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 573065005330 hinge; other site 573065005331 active site 573065005332 FeoA domain; Region: FeoA; pfam04023 573065005333 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 573065005334 ferrous iron transporter FeoB; Region: feoB; TIGR00437 573065005335 G1 box; other site 573065005336 GTP/Mg2+ binding site [chemical binding]; other site 573065005337 Switch I region; other site 573065005338 G2 box; other site 573065005339 G3 box; other site 573065005340 Switch II region; other site 573065005341 G4 box; other site 573065005342 G5 box; other site 573065005343 Nucleoside recognition; Region: Gate; pfam07670 573065005344 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 573065005345 Nucleoside recognition; Region: Gate; pfam07670 573065005346 S-S bond formation pathway protein; Provisional; Region: PHA02947; cl17416 573065005347 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 573065005348 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 573065005349 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 573065005350 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320 573065005351 active site 573065005352 catalytic site [active] 573065005353 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 573065005354 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 573065005355 Ca binding site [ion binding]; other site 573065005356 substrate binding site [chemical binding]; other site 573065005357 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 573065005358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573065005359 Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325 573065005360 putative transporter; Provisional; Region: PRK10484 573065005361 Na binding site [ion binding]; other site 573065005362 substrate binding site [chemical binding]; other site 573065005363 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 573065005364 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573065005365 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573065005366 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 573065005367 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065005368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065005369 DNA binding site [nucleotide binding] 573065005370 domain linker motif; other site 573065005371 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 573065005372 putative dimerization interface [polypeptide binding]; other site 573065005373 putative ligand binding site [chemical binding]; other site 573065005374 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 573065005375 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 573065005376 active site 573065005377 intersubunit interface [polypeptide binding]; other site 573065005378 catalytic residue [active] 573065005379 Glucokinase; Region: Glucokinase; pfam02685 573065005380 glucokinase, proteobacterial type; Region: glk; TIGR00749 573065005381 phosphogluconate dehydratase; Validated; Region: PRK09054 573065005382 6-phosphogluconate dehydratase; Region: edd; TIGR01196 573065005383 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 573065005384 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 573065005385 putative active site [active] 573065005386 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 573065005387 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 573065005388 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 573065005389 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 573065005390 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 573065005391 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 573065005392 heme-binding site [chemical binding]; other site 573065005393 aminopeptidase N; Provisional; Region: pepN; PRK14015 573065005394 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 573065005395 active site 573065005396 Zn binding site [ion binding]; other site 573065005397 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 573065005398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065005399 active site 573065005400 phosphorylation site [posttranslational modification] 573065005401 intermolecular recognition site; other site 573065005402 dimerization interface [polypeptide binding]; other site 573065005403 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573065005404 PAS fold; Region: PAS_7; pfam12860 573065005405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065005406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065005407 dimer interface [polypeptide binding]; other site 573065005408 phosphorylation site [posttranslational modification] 573065005409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065005410 ATP binding site [chemical binding]; other site 573065005411 Mg2+ binding site [ion binding]; other site 573065005412 G-X-G motif; other site 573065005413 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573065005414 EamA-like transporter family; Region: EamA; pfam00892 573065005415 Heavy-metal resistance; Region: Metal_resist; pfam13801 573065005416 RNA polymerase sigma factor; Reviewed; Region: PRK05602 573065005417 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065005418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065005419 DNA binding residues [nucleotide binding] 573065005420 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 573065005421 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 573065005422 metal binding triad; other site 573065005423 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 573065005424 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 573065005425 metal binding triad; other site 573065005426 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 573065005427 active site triad [active] 573065005428 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 573065005429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065005430 dimer interface [polypeptide binding]; other site 573065005431 phosphorylation site [posttranslational modification] 573065005432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065005433 ATP binding site [chemical binding]; other site 573065005434 Mg2+ binding site [ion binding]; other site 573065005435 G-X-G motif; other site 573065005436 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573065005437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065005438 active site 573065005439 phosphorylation site [posttranslational modification] 573065005440 intermolecular recognition site; other site 573065005441 dimerization interface [polypeptide binding]; other site 573065005442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065005443 DNA binding site [nucleotide binding] 573065005444 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 573065005445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065005446 NAD(P) binding site [chemical binding]; other site 573065005447 active site 573065005448 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573065005449 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 573065005450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065005451 Walker A/P-loop; other site 573065005452 ATP binding site [chemical binding]; other site 573065005453 Q-loop/lid; other site 573065005454 ABC transporter signature motif; other site 573065005455 Walker B; other site 573065005456 D-loop; other site 573065005457 H-loop/switch region; other site 573065005458 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 573065005459 active site 573065005460 catalytic triad [active] 573065005461 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 573065005462 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 573065005463 catalytic residues [active] 573065005464 Putative esterase; Region: Esterase; pfam00756 573065005465 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573065005466 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065005467 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065005468 DNA binding site [nucleotide binding] 573065005469 domain linker motif; other site 573065005470 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 573065005471 putative dimerization interface [polypeptide binding]; other site 573065005472 putative ligand binding site [chemical binding]; other site 573065005473 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 573065005474 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 573065005475 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 573065005476 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 573065005477 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573065005478 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 573065005479 MerC mercury resistance protein; Region: MerC; cl03934 573065005480 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 573065005481 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573065005482 NodB motif; other site 573065005483 active site 573065005484 catalytic site [active] 573065005485 metal binding site [ion binding]; metal-binding site 573065005486 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065005487 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065005488 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065005489 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065005490 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065005491 DNA binding site [nucleotide binding] 573065005492 domain linker motif; other site 573065005493 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 573065005494 putative dimerization interface [polypeptide binding]; other site 573065005495 putative ligand binding site [chemical binding]; other site 573065005496 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065005497 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065005498 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065005499 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065005500 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573065005501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065005502 active site 573065005503 phosphorylation site [posttranslational modification] 573065005504 intermolecular recognition site; other site 573065005505 dimerization interface [polypeptide binding]; other site 573065005506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065005507 DNA binding site [nucleotide binding] 573065005508 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 573065005509 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573065005510 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573065005511 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573065005512 MarR family; Region: MarR_2; pfam12802 573065005513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065005514 Response regulator receiver domain; Region: Response_reg; pfam00072 573065005515 active site 573065005516 phosphorylation site [posttranslational modification] 573065005517 intermolecular recognition site; other site 573065005518 dimerization interface [polypeptide binding]; other site 573065005519 Response regulator receiver domain; Region: Response_reg; pfam00072 573065005520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065005521 active site 573065005522 phosphorylation site [posttranslational modification] 573065005523 intermolecular recognition site; other site 573065005524 dimerization interface [polypeptide binding]; other site 573065005525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065005526 dimer interface [polypeptide binding]; other site 573065005527 phosphorylation site [posttranslational modification] 573065005528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065005529 ATP binding site [chemical binding]; other site 573065005530 Mg2+ binding site [ion binding]; other site 573065005531 G-X-G motif; other site 573065005532 Response regulator receiver domain; Region: Response_reg; pfam00072 573065005533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065005534 active site 573065005535 phosphorylation site [posttranslational modification] 573065005536 intermolecular recognition site; other site 573065005537 dimerization interface [polypeptide binding]; other site 573065005538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065005539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065005540 dimer interface [polypeptide binding]; other site 573065005541 phosphorylation site [posttranslational modification] 573065005542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065005543 ATP binding site [chemical binding]; other site 573065005544 Mg2+ binding site [ion binding]; other site 573065005545 G-X-G motif; other site 573065005546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065005547 Response regulator receiver domain; Region: Response_reg; pfam00072 573065005548 active site 573065005549 phosphorylation site [posttranslational modification] 573065005550 intermolecular recognition site; other site 573065005551 dimerization interface [polypeptide binding]; other site 573065005552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065005553 Response regulator receiver domain; Region: Response_reg; pfam00072 573065005554 active site 573065005555 phosphorylation site [posttranslational modification] 573065005556 intermolecular recognition site; other site 573065005557 dimerization interface [polypeptide binding]; other site 573065005558 CHASE3 domain; Region: CHASE3; pfam05227 573065005559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065005560 PAS fold; Region: PAS_3; pfam08447 573065005561 putative active site [active] 573065005562 heme pocket [chemical binding]; other site 573065005563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065005564 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 573065005565 dimer interface [polypeptide binding]; other site 573065005566 phosphorylation site [posttranslational modification] 573065005567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065005568 ATP binding site [chemical binding]; other site 573065005569 Mg2+ binding site [ion binding]; other site 573065005570 G-X-G motif; other site 573065005571 Entericidin EcnA/B family; Region: Entericidin; cl02322 573065005572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 573065005573 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 573065005574 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573065005575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065005576 DNA-binding site [nucleotide binding]; DNA binding site 573065005577 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573065005578 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 573065005579 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 573065005580 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 573065005581 Na binding site [ion binding]; other site 573065005582 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 573065005583 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573065005584 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573065005585 DNA binding residues [nucleotide binding] 573065005586 dimerization interface [polypeptide binding]; other site 573065005587 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 573065005588 Domain interface; other site 573065005589 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 573065005590 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 573065005591 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 573065005592 apolar tunnel; other site 573065005593 heme binding site [chemical binding]; other site 573065005594 dimerization interface [polypeptide binding]; other site 573065005595 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 573065005596 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573065005597 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573065005598 protein binding site [polypeptide binding]; other site 573065005599 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573065005600 protein binding site [polypeptide binding]; other site 573065005601 Cytochrome C biogenesis protein; Region: CcmH; cl01179 573065005602 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 573065005603 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 573065005604 TPR repeat; Region: TPR_11; pfam13414 573065005605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065005606 binding surface 573065005607 TPR motif; other site 573065005608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065005609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065005610 ATP binding site [chemical binding]; other site 573065005611 Mg2+ binding site [ion binding]; other site 573065005612 G-X-G motif; other site 573065005613 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573065005614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065005615 active site 573065005616 phosphorylation site [posttranslational modification] 573065005617 intermolecular recognition site; other site 573065005618 dimerization interface [polypeptide binding]; other site 573065005619 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065005620 DNA binding site [nucleotide binding] 573065005621 chaperone protein DnaJ; Provisional; Region: PRK14299 573065005622 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573065005623 HSP70 interaction site [polypeptide binding]; other site 573065005624 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573065005625 substrate binding site [polypeptide binding]; other site 573065005626 dimer interface [polypeptide binding]; other site 573065005627 hypothetical protein; Provisional; Region: PRK05170 573065005628 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573065005629 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573065005630 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573065005631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 573065005632 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 573065005633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065005634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065005635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573065005636 dimerization interface [polypeptide binding]; other site 573065005637 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 573065005638 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 573065005639 enoyl-CoA hydratase; Provisional; Region: PRK05995 573065005640 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573065005641 substrate binding site [chemical binding]; other site 573065005642 oxyanion hole (OAH) forming residues; other site 573065005643 trimer interface [polypeptide binding]; other site 573065005644 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 573065005645 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573065005646 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 573065005647 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 573065005648 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573065005649 carboxyltransferase (CT) interaction site; other site 573065005650 biotinylation site [posttranslational modification]; other site 573065005651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 573065005652 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 573065005653 substrate binding site [chemical binding]; other site 573065005654 FAD binding site [chemical binding]; other site 573065005655 catalytic base [active] 573065005656 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 573065005657 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 573065005658 active site 573065005659 catalytic residues [active] 573065005660 metal binding site [ion binding]; metal-binding site 573065005661 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 573065005662 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 573065005663 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 573065005664 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 573065005665 substrate binding site [chemical binding]; other site 573065005666 oxyanion hole (OAH) forming residues; other site 573065005667 trimer interface [polypeptide binding]; other site 573065005668 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 573065005669 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 573065005670 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 573065005671 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 573065005672 NAD binding site [chemical binding]; other site 573065005673 Phe binding site; other site 573065005674 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 573065005675 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573065005676 dimer interface [polypeptide binding]; other site 573065005677 PYR/PP interface [polypeptide binding]; other site 573065005678 TPP binding site [chemical binding]; other site 573065005679 substrate binding site [chemical binding]; other site 573065005680 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 573065005681 TPP-binding site; other site 573065005682 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 573065005683 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573065005684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065005685 putative DNA binding site [nucleotide binding]; other site 573065005686 putative Zn2+ binding site [ion binding]; other site 573065005687 AsnC family; Region: AsnC_trans_reg; pfam01037 573065005688 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 573065005689 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 573065005690 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 573065005691 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 573065005692 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 573065005693 [2Fe-2S] cluster binding site [ion binding]; other site 573065005694 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 573065005695 hydrophobic ligand binding site; other site 573065005696 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 573065005697 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 573065005698 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573065005699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065005700 NAD(P) binding site [chemical binding]; other site 573065005701 active site 573065005702 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 573065005703 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 573065005704 dimer interface [polypeptide binding]; other site 573065005705 active site 573065005706 CoA binding pocket [chemical binding]; other site 573065005707 thiamine pyrophosphate protein; Validated; Region: PRK08199 573065005708 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573065005709 PYR/PP interface [polypeptide binding]; other site 573065005710 dimer interface [polypeptide binding]; other site 573065005711 TPP binding site [chemical binding]; other site 573065005712 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573065005713 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 573065005714 TPP-binding site [chemical binding]; other site 573065005715 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 573065005716 CoA-transferase family III; Region: CoA_transf_3; pfam02515 573065005717 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 573065005718 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 573065005719 FAD binding site [chemical binding]; other site 573065005720 substrate binding pocket [chemical binding]; other site 573065005721 catalytic base [active] 573065005722 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 573065005723 aldehyde dehydrogenase family 7 member; Region: PLN02315 573065005724 tetrameric interface [polypeptide binding]; other site 573065005725 NAD binding site [chemical binding]; other site 573065005726 catalytic residues [active] 573065005727 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 573065005728 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 573065005729 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 573065005730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065005731 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 573065005732 dimerization interface [polypeptide binding]; other site 573065005733 substrate binding pocket [chemical binding]; other site 573065005734 ornithine cyclodeaminase; Validated; Region: PRK06141 573065005735 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 573065005736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065005737 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 573065005738 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 573065005739 mobile mystery protein A; Region: mob_myst_A; TIGR02612 573065005740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065005741 non-specific DNA binding site [nucleotide binding]; other site 573065005742 salt bridge; other site 573065005743 sequence-specific DNA binding site [nucleotide binding]; other site 573065005744 mobile mystery protein B; Region: mob_myst_B; TIGR02613 573065005745 Fic/DOC family; Region: Fic; pfam02661 573065005746 GcrA cell cycle regulator; Region: GcrA; pfam07750 573065005747 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065005748 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065005749 DNA binding site [nucleotide binding] 573065005750 domain linker motif; other site 573065005751 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 573065005752 putative ligand binding site [chemical binding]; other site 573065005753 putative dimerization interface [polypeptide binding]; other site 573065005754 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 573065005755 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 573065005756 dimer interface [polypeptide binding]; other site 573065005757 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 573065005758 active site 573065005759 Fe binding site [ion binding]; other site 573065005760 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573065005761 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065005762 DNA binding site [nucleotide binding] 573065005763 Uncharacterized conserved protein [Function unknown]; Region: COG4925 573065005764 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 573065005765 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 573065005766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065005767 putative substrate translocation pore; other site 573065005768 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065005769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065005770 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 573065005771 putative effector binding pocket; other site 573065005772 putative dimerization interface [polypeptide binding]; other site 573065005773 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573065005774 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573065005775 active site 573065005776 catalytic tetrad [active] 573065005777 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 573065005778 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 573065005779 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573065005780 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573065005781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065005782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065005783 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 573065005784 putative effector binding pocket; other site 573065005785 putative dimerization interface [polypeptide binding]; other site 573065005786 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 573065005787 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 573065005788 hypothetical protein; Reviewed; Region: PRK09588 573065005789 TROVE domain; Region: TROVE; pfam05731 573065005790 von Willebrand factor type A domain; Region: VWA_2; pfam13519 573065005791 metal ion-dependent adhesion site (MIDAS); other site 573065005792 Fic family protein [Function unknown]; Region: COG3177 573065005793 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 573065005794 Fic/DOC family; Region: Fic; pfam02661 573065005795 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 573065005796 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 573065005797 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065005798 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065005799 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 573065005800 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 573065005801 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 573065005802 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 573065005803 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 573065005804 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 573065005805 putative NAD(P) binding site [chemical binding]; other site 573065005806 active site 573065005807 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 573065005808 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 573065005809 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 573065005810 oxalacetate binding site [chemical binding]; other site 573065005811 citrylCoA binding site [chemical binding]; other site 573065005812 coenzyme A binding site [chemical binding]; other site 573065005813 catalytic triad [active] 573065005814 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 573065005815 Cation efflux family; Region: Cation_efflux; cl00316 573065005816 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 573065005817 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 573065005818 C-terminal domain interface [polypeptide binding]; other site 573065005819 GSH binding site (G-site) [chemical binding]; other site 573065005820 dimer interface [polypeptide binding]; other site 573065005821 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 573065005822 N-terminal domain interface [polypeptide binding]; other site 573065005823 dimer interface [polypeptide binding]; other site 573065005824 substrate binding pocket (H-site) [chemical binding]; other site 573065005825 epoxyqueuosine reductase; Region: TIGR00276 573065005826 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 573065005827 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 573065005828 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 573065005829 Probable Catalytic site; other site 573065005830 metal-binding site 573065005831 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 573065005832 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 573065005833 active site 573065005834 dimer interface [polypeptide binding]; other site 573065005835 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 573065005836 dimer interface [polypeptide binding]; other site 573065005837 active site 573065005838 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 573065005839 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 573065005840 active site 573065005841 dimer interface [polypeptide binding]; other site 573065005842 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 573065005843 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 573065005844 active site 573065005845 FMN binding site [chemical binding]; other site 573065005846 substrate binding site [chemical binding]; other site 573065005847 3Fe-4S cluster binding site [ion binding]; other site 573065005848 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 573065005849 domain interface; other site 573065005850 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 573065005851 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573065005852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573065005853 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 573065005854 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 573065005855 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573065005856 inhibitor-cofactor binding pocket; inhibition site 573065005857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065005858 catalytic residue [active] 573065005859 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 573065005860 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 573065005861 NAD(P) binding site [chemical binding]; other site 573065005862 catalytic residues [active] 573065005863 methionine sulfoxide reductase B; Provisional; Region: PRK00222 573065005864 SelR domain; Region: SelR; pfam01641 573065005865 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 573065005866 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573065005867 siroheme synthase; Provisional; Region: cysG; PRK10637 573065005868 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 573065005869 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 573065005870 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 573065005871 active site 573065005872 SAM binding site [chemical binding]; other site 573065005873 homodimer interface [polypeptide binding]; other site 573065005874 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 573065005875 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 573065005876 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 573065005877 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 573065005878 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 573065005879 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 573065005880 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 573065005881 Active Sites [active] 573065005882 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 573065005883 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 573065005884 dimerization interface [polypeptide binding]; other site 573065005885 domain crossover interface; other site 573065005886 redox-dependent activation switch; other site 573065005887 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573065005888 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 573065005889 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 573065005890 ligand binding site [chemical binding]; other site 573065005891 NAD binding site [chemical binding]; other site 573065005892 tetramer interface [polypeptide binding]; other site 573065005893 catalytic site [active] 573065005894 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 573065005895 L-serine binding site [chemical binding]; other site 573065005896 ACT domain interface; other site 573065005897 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 573065005898 mannose binding site [chemical binding]; other site 573065005899 dimerization interface [polypeptide binding]; other site 573065005900 PilZ domain; Region: PilZ; pfam07238 573065005901 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573065005902 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573065005903 ATP binding site [chemical binding]; other site 573065005904 Mg++ binding site [ion binding]; other site 573065005905 motif III; other site 573065005906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573065005907 nucleotide binding region [chemical binding]; other site 573065005908 ATP-binding site [chemical binding]; other site 573065005909 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 573065005910 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 573065005911 active site 573065005912 Zn binding site [ion binding]; other site 573065005913 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 573065005914 Response regulator receiver domain; Region: Response_reg; pfam00072 573065005915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065005916 active site 573065005917 phosphorylation site [posttranslational modification] 573065005918 intermolecular recognition site; other site 573065005919 dimerization interface [polypeptide binding]; other site 573065005920 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573065005921 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573065005922 substrate binding site [chemical binding]; other site 573065005923 ATP binding site [chemical binding]; other site 573065005924 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065005925 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065005926 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065005927 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 573065005928 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 573065005929 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 573065005930 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 573065005931 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573065005932 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573065005933 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573065005934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065005935 dimer interface [polypeptide binding]; other site 573065005936 conserved gate region; other site 573065005937 putative PBP binding loops; other site 573065005938 ABC-ATPase subunit interface; other site 573065005939 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573065005940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065005941 dimer interface [polypeptide binding]; other site 573065005942 conserved gate region; other site 573065005943 putative PBP binding loops; other site 573065005944 ABC-ATPase subunit interface; other site 573065005945 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 573065005946 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 573065005947 Walker A/P-loop; other site 573065005948 ATP binding site [chemical binding]; other site 573065005949 Q-loop/lid; other site 573065005950 ABC transporter signature motif; other site 573065005951 Walker B; other site 573065005952 D-loop; other site 573065005953 H-loop/switch region; other site 573065005954 TOBE domain; Region: TOBE_2; pfam08402 573065005955 hypothetical protein; Provisional; Region: PRK09273 573065005956 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 573065005957 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 573065005958 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 573065005959 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065005960 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065005961 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065005962 von Willebrand factor type A domain; Region: VWA_2; pfam13519 573065005963 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 573065005964 sequence-specific DNA binding site [nucleotide binding]; other site 573065005965 salt bridge; other site 573065005966 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 573065005967 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 573065005968 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 573065005969 NADP binding site [chemical binding]; other site 573065005970 homodimer interface [polypeptide binding]; other site 573065005971 active site 573065005972 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 573065005973 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 573065005974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065005975 NAD(P) binding site [chemical binding]; other site 573065005976 active site 573065005977 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065005978 putative DNA binding site [nucleotide binding]; other site 573065005979 putative Zn2+ binding site [ion binding]; other site 573065005980 L-rhamnonate dehydratase; Provisional; Region: PRK15440 573065005981 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 573065005982 putative active site pocket [active] 573065005983 putative metal binding site [ion binding]; other site 573065005984 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 573065005985 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 573065005986 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 573065005987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065005988 NAD(P) binding site [chemical binding]; other site 573065005989 active site 573065005990 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 573065005991 Amidohydrolase; Region: Amidohydro_2; pfam04909 573065005992 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 573065005993 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 573065005994 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 573065005995 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 573065005996 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 573065005997 dimer interface [polypeptide binding]; other site 573065005998 active site 573065005999 CoA binding pocket [chemical binding]; other site 573065006000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065006001 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 573065006002 NAD(P) binding site [chemical binding]; other site 573065006003 active site 573065006004 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 573065006005 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573065006006 acyl-activating enzyme (AAE) consensus motif; other site 573065006007 AMP binding site [chemical binding]; other site 573065006008 active site 573065006009 CoA binding site [chemical binding]; other site 573065006010 Phosphopantetheine attachment site; Region: PP-binding; cl09936 573065006011 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 573065006012 classical (c) SDRs; Region: SDR_c; cd05233 573065006013 NAD(P) binding site [chemical binding]; other site 573065006014 active site 573065006015 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 573065006016 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 573065006017 [2Fe-2S] cluster binding site [ion binding]; other site 573065006018 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 573065006019 alpha subunit interface [polypeptide binding]; other site 573065006020 active site 573065006021 substrate binding site [chemical binding]; other site 573065006022 Fe binding site [ion binding]; other site 573065006023 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 573065006024 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 573065006025 dimer interface [polypeptide binding]; other site 573065006026 active site 573065006027 CoA binding pocket [chemical binding]; other site 573065006028 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 573065006029 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 573065006030 ligand binding site; other site 573065006031 tetramer interface; other site 573065006032 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 573065006033 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 573065006034 active site 573065006035 catalytic residues [active] 573065006036 metal binding site [ion binding]; metal-binding site 573065006037 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 573065006038 HipA N-terminal domain; Region: Couple_hipA; pfam13657 573065006039 HipA-like N-terminal domain; Region: HipA_N; pfam07805 573065006040 HipA-like C-terminal domain; Region: HipA_C; pfam07804 573065006041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065006042 non-specific DNA binding site [nucleotide binding]; other site 573065006043 salt bridge; other site 573065006044 sequence-specific DNA binding site [nucleotide binding]; other site 573065006045 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 573065006046 putative active site [active] 573065006047 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 573065006048 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 573065006049 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 573065006050 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 573065006051 active site 573065006052 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 573065006053 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 573065006054 Beta-galactosidase, domain 2; Region: BetaGal_dom2; pfam10435 573065006055 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 573065006056 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 573065006057 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 573065006058 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 573065006059 active site 573065006060 catalytic triad [active] 573065006061 Domain of unknown function (DUF718); Region: DUF718; pfam05336 573065006062 HipA N-terminal domain; Region: Couple_hipA; pfam13657 573065006063 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 573065006064 HipA-like N-terminal domain; Region: HipA_N; pfam07805 573065006065 HipA-like C-terminal domain; Region: HipA_C; pfam07804 573065006066 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065006067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065006068 non-specific DNA binding site [nucleotide binding]; other site 573065006069 salt bridge; other site 573065006070 sequence-specific DNA binding site [nucleotide binding]; other site 573065006071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065006072 TPR motif; other site 573065006073 binding surface 573065006074 TPR repeat; Region: TPR_11; pfam13414 573065006075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573065006076 TPR motif; other site 573065006077 binding surface 573065006078 TPR repeat; Region: TPR_11; pfam13414 573065006079 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 573065006080 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573065006081 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573065006082 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573065006083 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573065006084 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573065006085 nucleotide binding site [chemical binding]; other site 573065006086 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 573065006087 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 573065006088 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 573065006089 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 573065006090 SWIM zinc finger; Region: SWIM; pfam04434 573065006091 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 573065006092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573065006093 ATP binding site [chemical binding]; other site 573065006094 putative Mg++ binding site [ion binding]; other site 573065006095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573065006096 nucleotide binding region [chemical binding]; other site 573065006097 ATP-binding site [chemical binding]; other site 573065006098 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065006099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065006100 non-specific DNA binding site [nucleotide binding]; other site 573065006101 salt bridge; other site 573065006102 sequence-specific DNA binding site [nucleotide binding]; other site 573065006103 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 573065006104 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 573065006105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 573065006106 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 573065006107 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573065006108 CoA binding site [chemical binding]; other site 573065006109 active site 573065006110 AMP binding site [chemical binding]; other site 573065006111 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 573065006112 Predicted membrane protein [Function unknown]; Region: COG4763 573065006113 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573065006114 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573065006115 Predicted integral membrane protein [Function unknown]; Region: COG5652 573065006116 Predicted membrane protein [Function unknown]; Region: COG2311 573065006117 Protein of unknown function (DUF418); Region: DUF418; pfam04235 573065006118 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 573065006119 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573065006120 active site 573065006121 metal binding site [ion binding]; metal-binding site 573065006122 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 573065006123 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 573065006124 SLBB domain; Region: SLBB; pfam10531 573065006125 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 573065006126 Chain length determinant protein; Region: Wzz; cl15801 573065006127 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 573065006128 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573065006129 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573065006130 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 573065006131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065006132 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573065006133 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573065006134 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 573065006135 O-Antigen ligase; Region: Wzy_C; pfam04932 573065006136 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573065006137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573065006138 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573065006139 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573065006140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573065006141 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573065006142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573065006143 Transposase; Region: HTH_Tnp_1; pfam01527 573065006144 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573065006145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573065006146 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573065006147 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573065006148 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573065006149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573065006150 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573065006151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573065006152 Transposase; Region: HTH_Tnp_1; pfam01527 573065006153 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 573065006154 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 573065006155 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573065006156 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573065006157 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 573065006158 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573065006159 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573065006160 active site 573065006161 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 573065006162 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 573065006163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065006164 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 573065006165 putative ADP-binding pocket [chemical binding]; other site 573065006166 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 573065006167 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573065006168 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 573065006169 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573065006170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065006171 NAD(P) binding site [chemical binding]; other site 573065006172 active site 573065006173 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573065006174 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065006175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065006176 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 573065006177 putative ADP-binding pocket [chemical binding]; other site 573065006178 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 573065006179 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573065006180 active site 573065006181 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573065006182 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 573065006183 active site 573065006184 catalytic residues [active] 573065006185 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573065006186 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 573065006187 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573065006188 active site 573065006189 metal binding site [ion binding]; metal-binding site 573065006190 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 573065006191 putative catalytic site [active] 573065006192 putative metal binding site [ion binding]; other site 573065006193 putative phosphate binding site [ion binding]; other site 573065006194 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 573065006195 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 573065006196 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573065006197 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 573065006198 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573065006199 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 573065006200 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 573065006201 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 573065006202 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 573065006203 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 573065006204 Substrate binding site; other site 573065006205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065006206 DNA-binding site [nucleotide binding]; DNA binding site 573065006207 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 573065006208 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 573065006209 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 573065006210 Ligand Binding Site [chemical binding]; other site 573065006211 Molecular Tunnel; other site 573065006212 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 573065006213 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065006214 Secretin and TonB N terminus short domain; Region: STN; smart00965 573065006215 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 573065006216 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065006217 N-terminal plug; other site 573065006218 ligand-binding site [chemical binding]; other site 573065006219 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 573065006220 FecR protein; Region: FecR; pfam04773 573065006221 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065006222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065006223 non-specific DNA binding site [nucleotide binding]; other site 573065006224 salt bridge; other site 573065006225 sequence-specific DNA binding site [nucleotide binding]; other site 573065006226 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573065006227 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065006228 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065006229 DNA binding residues [nucleotide binding] 573065006230 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 573065006231 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573065006232 Walker A motif; other site 573065006233 ATP binding site [chemical binding]; other site 573065006234 Walker B motif; other site 573065006235 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 573065006236 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 573065006237 Walker A motif; other site 573065006238 hexamer interface [polypeptide binding]; other site 573065006239 ATP binding site [chemical binding]; other site 573065006240 Walker B motif; other site 573065006241 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 573065006242 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 573065006243 VirB7 interaction site; other site 573065006244 VirB8 protein; Region: VirB8; pfam04335 573065006245 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 573065006246 Type IV secretion system proteins; Region: T4SS; pfam07996 573065006247 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 573065006248 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 573065006249 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 573065006250 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 573065006251 TrbC/VIRB2 family; Region: TrbC; pfam04956 573065006252 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 573065006253 DNA binding domain, excisionase family; Region: excise; TIGR01764 573065006254 PIN domain; Region: PIN_3; pfam13470 573065006255 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 573065006256 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 573065006257 homotetramer interface [polypeptide binding]; other site 573065006258 ligand binding site [chemical binding]; other site 573065006259 catalytic site [active] 573065006260 NAD binding site [chemical binding]; other site 573065006261 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 573065006262 biotin synthase; Region: bioB; TIGR00433 573065006263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065006264 FeS/SAM binding site; other site 573065006265 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 573065006266 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 573065006267 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 573065006268 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 573065006269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065006270 FeS/SAM binding site; other site 573065006271 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 573065006272 Protein of unknown function (DUF560); Region: DUF560; pfam04575 573065006273 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 573065006274 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 573065006275 substrate binding site; other site 573065006276 tetramer interface; other site 573065006277 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 573065006278 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 573065006279 NADP binding site [chemical binding]; other site 573065006280 active site 573065006281 putative substrate binding site [chemical binding]; other site 573065006282 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 573065006283 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 573065006284 NAD binding site [chemical binding]; other site 573065006285 substrate binding site [chemical binding]; other site 573065006286 homodimer interface [polypeptide binding]; other site 573065006287 active site 573065006288 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 573065006289 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 573065006290 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 573065006291 active site 573065006292 Zn binding site [ion binding]; other site 573065006293 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 573065006294 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573065006295 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 573065006296 Probable Catalytic site; other site 573065006297 metal-binding site 573065006298 GSCFA family; Region: GSCFA; pfam08885 573065006299 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573065006300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065006301 S-adenosylmethionine binding site [chemical binding]; other site 573065006302 Protein of unknown function (DUF563); Region: DUF563; pfam04577 573065006303 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573065006304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065006305 active site 573065006306 FAD dependent oxidoreductase; Region: DAO; pfam01266 573065006307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573065006308 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573065006309 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573065006310 active site 573065006311 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065006312 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573065006313 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 573065006314 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 573065006315 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 573065006316 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 573065006317 Walker A/P-loop; other site 573065006318 ATP binding site [chemical binding]; other site 573065006319 Q-loop/lid; other site 573065006320 ABC transporter signature motif; other site 573065006321 Walker B; other site 573065006322 D-loop; other site 573065006323 H-loop/switch region; other site 573065006324 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 573065006325 trimer interface [polypeptide binding]; other site 573065006326 active site 573065006327 substrate binding site [chemical binding]; other site 573065006328 CoA binding site [chemical binding]; other site 573065006329 Protein of unknown function (DUF563); Region: DUF563; pfam04577 573065006330 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 573065006331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573065006332 active site 573065006333 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 573065006334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573065006335 active site 573065006336 motif I; other site 573065006337 motif II; other site 573065006338 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573065006339 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 573065006340 Probable Catalytic site; other site 573065006341 metal-binding site 573065006342 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 573065006343 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 573065006344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065006345 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573065006346 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 573065006347 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 573065006348 putative active site [active] 573065006349 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 573065006350 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 573065006351 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 573065006352 Ligand binding site; other site 573065006353 oligomer interface; other site 573065006354 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 573065006355 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 573065006356 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 573065006357 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 573065006358 CysD dimerization site [polypeptide binding]; other site 573065006359 G1 box; other site 573065006360 putative GEF interaction site [polypeptide binding]; other site 573065006361 GTP/Mg2+ binding site [chemical binding]; other site 573065006362 Switch I region; other site 573065006363 G2 box; other site 573065006364 G3 box; other site 573065006365 Switch II region; other site 573065006366 G4 box; other site 573065006367 G5 box; other site 573065006368 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 573065006369 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 573065006370 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 573065006371 ligand-binding site [chemical binding]; other site 573065006372 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 573065006373 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 573065006374 Active Sites [active] 573065006375 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 573065006376 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 573065006377 active site 573065006378 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 573065006379 dimerization interface [polypeptide binding]; other site 573065006380 putative active cleft [active] 573065006381 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 573065006382 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 573065006383 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 573065006384 tetramer interface [polypeptide binding]; other site 573065006385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065006386 catalytic residue [active] 573065006387 thymidine kinase; Provisional; Region: PRK04296 573065006388 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573065006389 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573065006390 DNA binding residues [nucleotide binding] 573065006391 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065006392 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065006393 non-specific DNA binding site [nucleotide binding]; other site 573065006394 salt bridge; other site 573065006395 sequence-specific DNA binding site [nucleotide binding]; other site 573065006396 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 573065006397 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 573065006398 nudix motif; other site 573065006399 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 573065006400 active site clefts [active] 573065006401 zinc binding site [ion binding]; other site 573065006402 dimer interface [polypeptide binding]; other site 573065006403 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573065006404 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 573065006405 Probable Catalytic site; other site 573065006406 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 573065006407 active site 573065006408 catalytic residues [active] 573065006409 NAD synthetase; Reviewed; Region: nadE; PRK02628 573065006410 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 573065006411 multimer interface [polypeptide binding]; other site 573065006412 active site 573065006413 catalytic triad [active] 573065006414 protein interface 1 [polypeptide binding]; other site 573065006415 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 573065006416 homodimer interface [polypeptide binding]; other site 573065006417 NAD binding pocket [chemical binding]; other site 573065006418 ATP binding pocket [chemical binding]; other site 573065006419 Mg binding site [ion binding]; other site 573065006420 active-site loop [active] 573065006421 threonine dehydratase; Provisional; Region: PRK07334 573065006422 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 573065006423 tetramer interface [polypeptide binding]; other site 573065006424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065006425 catalytic residue [active] 573065006426 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 573065006427 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 573065006428 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 573065006429 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573065006430 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 573065006431 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 573065006432 NAD binding site [chemical binding]; other site 573065006433 homodimer interface [polypeptide binding]; other site 573065006434 active site 573065006435 substrate binding site [chemical binding]; other site 573065006436 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 573065006437 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 573065006438 active site 573065006439 substrate binding site [chemical binding]; other site 573065006440 metal binding site [ion binding]; metal-binding site 573065006441 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 573065006442 active site 573065006443 tetramer interface; other site 573065006444 Beta-lactamase; Region: Beta-lactamase; pfam00144 573065006445 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573065006446 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 573065006447 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 573065006448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065006449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065006450 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 573065006451 dimerization interface [polypeptide binding]; other site 573065006452 Uncharacterized conserved protein [Function unknown]; Region: COG2835 573065006453 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 573065006454 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573065006455 catalytic residues [active] 573065006456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065006457 binding surface 573065006458 TPR motif; other site 573065006459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065006460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573065006461 putative substrate translocation pore; other site 573065006462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065006463 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 573065006464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065006465 active site 573065006466 phosphorylation site [posttranslational modification] 573065006467 intermolecular recognition site; other site 573065006468 dimerization interface [polypeptide binding]; other site 573065006469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573065006470 DNA binding site [nucleotide binding] 573065006471 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 573065006472 PhoU domain; Region: PhoU; pfam01895 573065006473 PhoU domain; Region: PhoU; pfam01895 573065006474 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573065006475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065006476 dimer interface [polypeptide binding]; other site 573065006477 phosphorylation site [posttranslational modification] 573065006478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065006479 ATP binding site [chemical binding]; other site 573065006480 Mg2+ binding site [ion binding]; other site 573065006481 G-X-G motif; other site 573065006482 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 573065006483 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 573065006484 putative catalytic cysteine [active] 573065006485 gamma-glutamyl kinase; Provisional; Region: PRK05429 573065006486 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 573065006487 nucleotide binding site [chemical binding]; other site 573065006488 homotetrameric interface [polypeptide binding]; other site 573065006489 putative phosphate binding site [ion binding]; other site 573065006490 putative allosteric binding site; other site 573065006491 PUA domain; Region: PUA; pfam01472 573065006492 threonine synthase; Validated; Region: PRK09225 573065006493 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 573065006494 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573065006495 catalytic residue [active] 573065006496 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573065006497 MULE transposase domain; Region: MULE; pfam10551 573065006498 Response regulator receiver domain; Region: Response_reg; pfam00072 573065006499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065006500 active site 573065006501 phosphorylation site [posttranslational modification] 573065006502 intermolecular recognition site; other site 573065006503 dimerization interface [polypeptide binding]; other site 573065006504 Response regulator receiver domain; Region: Response_reg; pfam00072 573065006505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065006506 active site 573065006507 phosphorylation site [posttranslational modification] 573065006508 intermolecular recognition site; other site 573065006509 dimerization interface [polypeptide binding]; other site 573065006510 PAS fold; Region: PAS_7; pfam12860 573065006511 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573065006512 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573065006513 metal binding site [ion binding]; metal-binding site 573065006514 active site 573065006515 I-site; other site 573065006516 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573065006517 FIST N domain; Region: FIST; pfam08495 573065006518 FIST C domain; Region: FIST_C; pfam10442 573065006519 TraB family; Region: TraB; pfam01963 573065006520 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065006521 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065006522 dimer interface [polypeptide binding]; other site 573065006523 putative CheW interface [polypeptide binding]; other site 573065006524 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 573065006525 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573065006526 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573065006527 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 573065006528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065006529 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 573065006530 dimerization interface [polypeptide binding]; other site 573065006531 substrate binding pocket [chemical binding]; other site 573065006532 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 573065006533 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573065006534 dimer interface [polypeptide binding]; other site 573065006535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065006536 catalytic residue [active] 573065006537 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 573065006538 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 573065006539 putative active site [active] 573065006540 putative substrate binding site [chemical binding]; other site 573065006541 ATP binding site [chemical binding]; other site 573065006542 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 573065006543 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573065006544 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002 573065006545 active site 573065006546 MltA-interacting protein MipA; Region: MipA; cl01504 573065006547 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 573065006548 nucleophile elbow; other site 573065006549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065006550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065006551 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 573065006552 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 573065006553 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573065006554 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573065006555 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 573065006556 catalytic motif [active] 573065006557 Catalytic residue [active] 573065006558 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 573065006559 catalytic motif [active] 573065006560 Catalytic residue [active] 573065006561 DNA primase; Validated; Region: dnaG; PRK05667 573065006562 CHC2 zinc finger; Region: zf-CHC2; cl17510 573065006563 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 573065006564 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 573065006565 active site 573065006566 metal binding site [ion binding]; metal-binding site 573065006567 interdomain interaction site; other site 573065006568 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 573065006569 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573065006570 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 573065006571 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 573065006572 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065006573 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573065006574 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065006575 DNA binding residues [nucleotide binding] 573065006576 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 573065006577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 573065006578 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 573065006579 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 573065006580 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 573065006581 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 573065006582 substrate binding site [chemical binding]; other site 573065006583 active site 573065006584 catalytic residues [active] 573065006585 heterodimer interface [polypeptide binding]; other site 573065006586 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 573065006587 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 573065006588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065006589 catalytic residue [active] 573065006590 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 573065006591 active site 573065006592 glucokinase, proteobacterial type; Region: glk; TIGR00749 573065006593 Glucokinase; Region: Glucokinase; cl17310 573065006594 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 573065006595 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 573065006596 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573065006597 IHF dimer interface [polypeptide binding]; other site 573065006598 IHF - DNA interface [nucleotide binding]; other site 573065006599 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 573065006600 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 573065006601 RNA binding site [nucleotide binding]; other site 573065006602 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 573065006603 RNA binding site [nucleotide binding]; other site 573065006604 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 573065006605 RNA binding site [nucleotide binding]; other site 573065006606 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573065006607 RNA binding site [nucleotide binding]; other site 573065006608 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 573065006609 RNA binding site [nucleotide binding]; other site 573065006610 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 573065006611 RNA binding site [nucleotide binding]; other site 573065006612 cytidylate kinase; Provisional; Region: cmk; PRK00023 573065006613 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 573065006614 CMP-binding site; other site 573065006615 The sites determining sugar specificity; other site 573065006616 TIGR02300 family protein; Region: FYDLN_acid 573065006617 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 573065006618 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 573065006619 Predicted acetyltransferase [General function prediction only]; Region: COG2388 573065006620 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 573065006621 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065006622 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065006623 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573065006624 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573065006625 active site 573065006626 catalytic tetrad [active] 573065006627 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 573065006628 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 573065006629 EamA-like transporter family; Region: EamA; pfam00892 573065006630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065006631 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 573065006632 putative substrate translocation pore; other site 573065006633 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 573065006634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573065006635 ATP binding site [chemical binding]; other site 573065006636 putative Mg++ binding site [ion binding]; other site 573065006637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573065006638 nucleotide binding region [chemical binding]; other site 573065006639 ATP-binding site [chemical binding]; other site 573065006640 RQC domain; Region: RQC; cl09632 573065006641 Transglycosylase; Region: Transgly; pfam00912 573065006642 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 573065006643 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573065006644 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573065006645 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573065006646 active site 573065006647 catalytic tetrad [active] 573065006648 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 573065006649 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 573065006650 DNA binding site [nucleotide binding] 573065006651 catalytic residue [active] 573065006652 H2TH interface [polypeptide binding]; other site 573065006653 putative catalytic residues [active] 573065006654 turnover-facilitating residue; other site 573065006655 intercalation triad [nucleotide binding]; other site 573065006656 8OG recognition residue [nucleotide binding]; other site 573065006657 putative reading head residues; other site 573065006658 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 573065006659 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 573065006660 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 573065006661 Uncharacterized conserved protein [Function unknown]; Region: COG4544 573065006662 DNA Polymerase Y-family; Region: PolY_like; cd03468 573065006663 active site 573065006664 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 573065006665 DNA binding site [nucleotide binding] 573065006666 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 573065006667 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 573065006668 putative active site [active] 573065006669 putative PHP Thumb interface [polypeptide binding]; other site 573065006670 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 573065006671 generic binding surface I; other site 573065006672 generic binding surface II; other site 573065006673 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 573065006674 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065006675 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065006676 N-terminal plug; other site 573065006677 ligand-binding site [chemical binding]; other site 573065006678 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573065006679 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 573065006680 putative hydrophobic ligand binding site [chemical binding]; other site 573065006681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065006682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065006683 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573065006684 dimerization interface [polypeptide binding]; other site 573065006685 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573065006686 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065006687 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065006688 DNA binding residues [nucleotide binding] 573065006689 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 573065006690 FecR protein; Region: FecR; pfam04773 573065006691 Secretin and TonB N terminus short domain; Region: STN; smart00965 573065006692 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 573065006693 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065006694 N-terminal plug; other site 573065006695 ligand-binding site [chemical binding]; other site 573065006696 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 573065006697 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 573065006698 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 573065006699 Secretin and TonB N terminus short domain; Region: STN; smart00965 573065006700 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065006701 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065006702 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 573065006703 FecR protein; Region: FecR; pfam04773 573065006704 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 573065006705 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065006706 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065006707 DNA binding residues [nucleotide binding] 573065006708 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 573065006709 benzoate transport; Region: 2A0115; TIGR00895 573065006710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065006711 putative substrate translocation pore; other site 573065006712 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 573065006713 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 573065006714 putative active site [active] 573065006715 Fe(II) binding site [ion binding]; other site 573065006716 putative dimer interface [polypeptide binding]; other site 573065006717 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 573065006718 dimer interface [polypeptide binding]; other site 573065006719 tetramer interface [polypeptide binding]; other site 573065006720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065006721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065006722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065006723 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 573065006724 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573065006725 dimerization interface [polypeptide binding]; other site 573065006726 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065006727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065006728 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 573065006729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573065006730 dimerization interface [polypeptide binding]; other site 573065006731 hypothetical protein; Provisional; Region: PRK09262 573065006732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 573065006733 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 573065006734 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 573065006735 Amidohydrolase; Region: Amidohydro_2; pfam04909 573065006736 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 573065006737 heme-binding site [chemical binding]; other site 573065006738 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065006739 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065006740 dimer interface [polypeptide binding]; other site 573065006741 putative CheW interface [polypeptide binding]; other site 573065006742 LytTr DNA-binding domain; Region: LytTR; smart00850 573065006743 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 573065006744 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573065006745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573065006746 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573065006747 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 573065006748 heme-binding site [chemical binding]; other site 573065006749 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065006750 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065006751 dimer interface [polypeptide binding]; other site 573065006752 putative CheW interface [polypeptide binding]; other site 573065006753 Response regulator receiver domain; Region: Response_reg; pfam00072 573065006754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065006755 active site 573065006756 phosphorylation site [posttranslational modification] 573065006757 intermolecular recognition site; other site 573065006758 dimerization interface [polypeptide binding]; other site 573065006759 Response regulator receiver domain; Region: Response_reg; pfam00072 573065006760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065006761 active site 573065006762 phosphorylation site [posttranslational modification] 573065006763 intermolecular recognition site; other site 573065006764 dimerization interface [polypeptide binding]; other site 573065006765 Predicted transcriptional regulators [Transcription]; Region: COG1695 573065006766 Transcriptional regulator PadR-like family; Region: PadR; cl17335 573065006767 Aspartyl protease; Region: Asp_protease_2; pfam13650 573065006768 inhibitor binding site; inhibition site 573065006769 catalytic motif [active] 573065006770 Catalytic residue [active] 573065006771 Active site flap [active] 573065006772 Beta-lactamase; Region: Beta-lactamase; pfam00144 573065006773 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573065006774 SnoaL-like domain; Region: SnoaL_3; pfam13474 573065006775 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 573065006776 active site 573065006777 Helix-turn-helix domain; Region: HTH_18; pfam12833 573065006778 Autoinducer binding domain; Region: Autoind_bind; pfam03472 573065006779 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573065006780 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573065006781 DNA binding residues [nucleotide binding] 573065006782 dimerization interface [polypeptide binding]; other site 573065006783 Autoinducer synthetase; Region: Autoind_synth; cl17404 573065006784 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 573065006785 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573065006786 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 573065006787 Walker A/P-loop; other site 573065006788 ATP binding site [chemical binding]; other site 573065006789 Q-loop/lid; other site 573065006790 ABC transporter signature motif; other site 573065006791 Walker B; other site 573065006792 D-loop; other site 573065006793 H-loop/switch region; other site 573065006794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065006795 non-specific DNA binding site [nucleotide binding]; other site 573065006796 salt bridge; other site 573065006797 sequence-specific DNA binding site [nucleotide binding]; other site 573065006798 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065006799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065006800 non-specific DNA binding site [nucleotide binding]; other site 573065006801 salt bridge; other site 573065006802 sequence-specific DNA binding site [nucleotide binding]; other site 573065006803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065006804 sequence-specific DNA binding site [nucleotide binding]; other site 573065006805 salt bridge; other site 573065006806 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573065006807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065006808 DNA binding residues [nucleotide binding] 573065006809 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 573065006810 FecR protein; Region: FecR; pfam04773 573065006811 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 573065006812 HEAT repeats; Region: HEAT_2; pfam13646 573065006813 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573065006814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573065006815 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573065006816 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 573065006817 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573065006818 MULE transposase domain; Region: MULE; pfam10551 573065006819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065006820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065006821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 573065006822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065006823 ABC transporter signature motif; other site 573065006824 Walker B; other site 573065006825 D-loop; other site 573065006826 H-loop/switch region; other site 573065006827 Secretin and TonB N terminus short domain; Region: STN; smart00965 573065006828 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065006829 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065006830 N-terminal plug; other site 573065006831 ligand-binding site [chemical binding]; other site 573065006832 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 573065006833 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065006834 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 573065006835 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 573065006836 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 573065006837 Transcriptional regulators [Transcription]; Region: GntR; COG1802 573065006838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065006839 DNA-binding site [nucleotide binding]; DNA binding site 573065006840 ParB-like nuclease domain; Region: ParBc; pfam02195 573065006841 Protein of unknown function (DUF736); Region: DUF736; pfam05284 573065006842 Helix-turn-helix domain; Region: HTH_17; pfam12728 573065006843 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 573065006844 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 573065006845 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573065006846 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573065006847 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573065006848 catalytic residue [active] 573065006849 Transposase; Region: DEDD_Tnp_IS110; pfam01548 573065006850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 573065006851 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 573065006852 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 573065006853 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 573065006854 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 573065006855 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573065006856 IHF dimer interface [polypeptide binding]; other site 573065006857 IHF - DNA interface [nucleotide binding]; other site 573065006858 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 573065006859 active site 573065006860 iron coordination sites [ion binding]; other site 573065006861 substrate binding pocket [chemical binding]; other site 573065006862 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 573065006863 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573065006864 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 573065006865 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 573065006866 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 573065006867 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573065006868 active site 573065006869 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 573065006870 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 573065006871 putative active site [active] 573065006872 metal binding site [ion binding]; metal-binding site 573065006873 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 573065006874 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573065006875 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573065006876 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573065006877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065006878 putative substrate translocation pore; other site 573065006879 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573065006880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573065006881 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 573065006882 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 573065006883 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 573065006884 [2Fe-2S] cluster binding site [ion binding]; other site 573065006885 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 573065006886 putative alpha subunit interface [polypeptide binding]; other site 573065006887 putative active site [active] 573065006888 putative substrate binding site [chemical binding]; other site 573065006889 Fe binding site [ion binding]; other site 573065006890 short chain dehydrogenase; Provisional; Region: PRK06180 573065006891 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 573065006892 NADP binding site [chemical binding]; other site 573065006893 active site 573065006894 steroid binding site; other site 573065006895 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065006896 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 573065006897 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065006898 Carboxylesterase family; Region: COesterase; pfam00135 573065006899 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573065006900 substrate binding pocket [chemical binding]; other site 573065006901 catalytic triad [active] 573065006902 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573065006903 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 573065006904 substrate binding site [chemical binding]; other site 573065006905 dimer interface [polypeptide binding]; other site 573065006906 ATP binding site [chemical binding]; other site 573065006907 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573065006908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573065006909 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 573065006910 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 573065006911 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 573065006912 FMN-binding pocket [chemical binding]; other site 573065006913 flavin binding motif; other site 573065006914 phosphate binding motif [ion binding]; other site 573065006915 beta-alpha-beta structure motif; other site 573065006916 NAD binding pocket [chemical binding]; other site 573065006917 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573065006918 catalytic loop [active] 573065006919 iron binding site [ion binding]; other site 573065006920 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 573065006921 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 573065006922 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 573065006923 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573065006924 Walker A motif; other site 573065006925 ATP binding site [chemical binding]; other site 573065006926 Walker B motif; other site 573065006927 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 573065006928 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 573065006929 ATP binding site [chemical binding]; other site 573065006930 Walker A motif; other site 573065006931 hexamer interface [polypeptide binding]; other site 573065006932 Walker B motif; other site 573065006933 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 573065006934 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 573065006935 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 573065006936 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 573065006937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065006938 Walker A/P-loop; other site 573065006939 ATP binding site [chemical binding]; other site 573065006940 Q-loop/lid; other site 573065006941 ABC transporter signature motif; other site 573065006942 Walker B; other site 573065006943 D-loop; other site 573065006944 H-loop/switch region; other site 573065006945 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 573065006946 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 573065006947 conjugal transfer protein TrbL; Provisional; Region: PRK13875 573065006948 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 573065006949 conjugal transfer protein TrbF; Provisional; Region: PRK13872 573065006950 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 573065006951 VirB7 interaction site; other site 573065006952 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 573065006953 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 573065006954 Helix-turn-helix domain; Region: HTH_17; pfam12728 573065006955 methionine sulfoxide reductase A; Provisional; Region: PRK00058 573065006956 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 573065006957 putative substrate binding site [chemical binding]; other site 573065006958 putative ATP binding site [chemical binding]; other site 573065006959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 573065006960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 573065006961 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573065006962 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 573065006963 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065006964 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573065006965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065006966 putative DNA binding site [nucleotide binding]; other site 573065006967 putative Zn2+ binding site [ion binding]; other site 573065006968 recombinase A; Provisional; Region: recA; PRK09354 573065006969 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 573065006970 hexamer interface [polypeptide binding]; other site 573065006971 Walker A motif; other site 573065006972 ATP binding site [chemical binding]; other site 573065006973 Walker B motif; other site 573065006974 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 573065006975 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 573065006976 motif 1; other site 573065006977 active site 573065006978 motif 2; other site 573065006979 motif 3; other site 573065006980 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573065006981 DHHA1 domain; Region: DHHA1; pfam02272 573065006982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065006983 short chain dehydrogenase; Validated; Region: PRK07069 573065006984 NAD(P) binding site [chemical binding]; other site 573065006985 active site 573065006986 Predicted membrane protein [Function unknown]; Region: COG2119 573065006987 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 573065006988 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 573065006989 Membrane transport protein; Region: Mem_trans; cl09117 573065006990 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 573065006991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 573065006992 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 573065006993 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 573065006994 active site 573065006995 catalytic triad [active] 573065006996 oxyanion hole [active] 573065006997 isocitrate dehydrogenase; Validated; Region: PRK08299 573065006998 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 573065006999 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573065007000 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 573065007001 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 573065007002 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 573065007003 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 573065007004 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 573065007005 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 573065007006 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 573065007007 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 573065007008 active site 573065007009 homotetramer interface [polypeptide binding]; other site 573065007010 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573065007011 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573065007012 Pirin-related protein [General function prediction only]; Region: COG1741 573065007013 Pirin; Region: Pirin; pfam02678 573065007014 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 573065007015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065007016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065007017 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 573065007018 putative effector binding pocket; other site 573065007019 dimerization interface [polypeptide binding]; other site 573065007020 amidase; Provisional; Region: PRK09201 573065007021 Amidase; Region: Amidase; cl11426 573065007022 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 573065007023 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 573065007024 allantoate amidohydrolase; Reviewed; Region: PRK09290 573065007025 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 573065007026 active site 573065007027 metal binding site [ion binding]; metal-binding site 573065007028 dimer interface [polypeptide binding]; other site 573065007029 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 573065007030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573065007031 catalytic residue [active] 573065007032 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 573065007033 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 573065007034 active site 573065007035 catalytic site [active] 573065007036 tetramer interface [polypeptide binding]; other site 573065007037 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 573065007038 SnoaL-like domain; Region: SnoaL_3; pfam13474 573065007039 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 573065007040 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 573065007041 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 573065007042 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 573065007043 active site 573065007044 homotetramer interface [polypeptide binding]; other site 573065007045 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 573065007046 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573065007047 catalytic loop [active] 573065007048 iron binding site [ion binding]; other site 573065007049 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573065007050 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 573065007051 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 573065007052 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573065007053 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573065007054 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 573065007055 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 573065007056 XdhC Rossmann domain; Region: XdhC_C; pfam13478 573065007057 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 573065007058 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 573065007059 active site 573065007060 purine riboside binding site [chemical binding]; other site 573065007061 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573065007062 guanine deaminase; Region: guan_deamin; TIGR02967 573065007063 active site 573065007064 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 573065007065 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 573065007066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573065007067 Zn2+ binding site [ion binding]; other site 573065007068 Mg2+ binding site [ion binding]; other site 573065007069 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 573065007070 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 573065007071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573065007072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573065007073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573065007074 metal binding site [ion binding]; metal-binding site 573065007075 active site 573065007076 I-site; other site 573065007077 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 573065007078 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 573065007079 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 573065007080 NAD binding site [chemical binding]; other site 573065007081 ATP-grasp domain; Region: ATP-grasp; pfam02222 573065007082 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 573065007083 COQ9; Region: COQ9; pfam08511 573065007084 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 573065007085 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 573065007086 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 573065007087 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 573065007088 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 573065007089 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 573065007090 putative ligand binding site [chemical binding]; other site 573065007091 NAD binding site [chemical binding]; other site 573065007092 dimerization interface [polypeptide binding]; other site 573065007093 catalytic site [active] 573065007094 amidase; Provisional; Region: PRK08137 573065007095 Amidase; Region: Amidase; pfam01425 573065007096 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 573065007097 flagellar motor protein MotA; Validated; Region: PRK09110 573065007098 Uncharacterized conserved protein [Function unknown]; Region: COG4121 573065007099 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 573065007100 GTP-binding protein LepA; Provisional; Region: PRK05433 573065007101 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 573065007102 G1 box; other site 573065007103 putative GEF interaction site [polypeptide binding]; other site 573065007104 GTP/Mg2+ binding site [chemical binding]; other site 573065007105 Switch I region; other site 573065007106 G2 box; other site 573065007107 G3 box; other site 573065007108 Switch II region; other site 573065007109 G4 box; other site 573065007110 G5 box; other site 573065007111 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 573065007112 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 573065007113 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 573065007114 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 573065007115 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 573065007116 active site 573065007117 catalytic triad [active] 573065007118 oxyanion hole [active] 573065007119 Protein of unknown function (DUF419); Region: DUF419; cl15265 573065007120 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 573065007121 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065007122 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065007123 N-terminal plug; other site 573065007124 ligand-binding site [chemical binding]; other site 573065007125 putative oxidoreductase; Provisional; Region: PRK11579 573065007126 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573065007127 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573065007128 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 573065007129 Protein of unknown function (DUF805); Region: DUF805; pfam05656 573065007130 Uncharacterized conserved protein [Function unknown]; Region: COG2968 573065007131 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 573065007132 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 573065007133 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 573065007134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 573065007135 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 573065007136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 573065007137 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 573065007138 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065007139 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065007140 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065007141 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065007142 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 573065007143 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065007144 alpha-galactosidase; Region: PLN02808; cl17638 573065007145 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 573065007146 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573065007147 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 573065007148 inhibitor site; inhibition site 573065007149 active site 573065007150 dimer interface [polypeptide binding]; other site 573065007151 catalytic residue [active] 573065007152 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 573065007153 substrate binding site [chemical binding]; other site 573065007154 active site 573065007155 beta-D-glucuronidase; Provisional; Region: PRK10150 573065007156 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065007157 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065007158 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065007159 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 573065007160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065007161 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 573065007162 ANTAR domain; Region: ANTAR; pfam03861 573065007163 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 573065007164 NMT1-like family; Region: NMT1_2; pfam13379 573065007165 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 573065007166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573065007167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573065007168 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573065007169 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573065007170 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 573065007171 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 573065007172 [2Fe-2S] cluster binding site [ion binding]; other site 573065007173 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 573065007174 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 573065007175 [4Fe-4S] binding site [ion binding]; other site 573065007176 molybdopterin cofactor binding site; other site 573065007177 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 573065007178 molybdopterin cofactor binding site; other site 573065007179 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573065007180 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065007181 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065007182 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065007183 Pirin-related protein [General function prediction only]; Region: COG1741 573065007184 Pirin; Region: Pirin; pfam02678 573065007185 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 573065007186 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 573065007187 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 573065007188 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 573065007189 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 573065007190 protein binding site [polypeptide binding]; other site 573065007191 Pectic acid lyase; Region: Pec_lyase; pfam09492 573065007192 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 573065007193 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573065007194 substrate binding pocket [chemical binding]; other site 573065007195 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065007196 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 573065007197 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573065007198 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573065007199 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 573065007200 RNA methyltransferase, RsmE family; Region: TIGR00046 573065007201 glutamate--cysteine ligase; Region: PLN02611 573065007202 POT family; Region: PTR2; cl17359 573065007203 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 573065007204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065007205 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065007206 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065007207 protease TldD; Provisional; Region: tldD; PRK10735 573065007208 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 573065007209 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 573065007210 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 573065007211 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 573065007212 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 573065007213 Subunit I/III interface [polypeptide binding]; other site 573065007214 D-pathway; other site 573065007215 Subunit I/VIIc interface [polypeptide binding]; other site 573065007216 Subunit I/IV interface [polypeptide binding]; other site 573065007217 Subunit I/II interface [polypeptide binding]; other site 573065007218 Low-spin heme (heme a) binding site [chemical binding]; other site 573065007219 Subunit I/VIIa interface [polypeptide binding]; other site 573065007220 Subunit I/VIa interface [polypeptide binding]; other site 573065007221 Dimer interface; other site 573065007222 Putative water exit pathway; other site 573065007223 Binuclear center (heme a3/CuB) [ion binding]; other site 573065007224 K-pathway; other site 573065007225 Subunit I/Vb interface [polypeptide binding]; other site 573065007226 Putative proton exit pathway; other site 573065007227 Subunit I/VIb interface; other site 573065007228 Subunit I/VIc interface [polypeptide binding]; other site 573065007229 Electron transfer pathway; other site 573065007230 Subunit I/VIIIb interface [polypeptide binding]; other site 573065007231 Subunit I/VIIb interface [polypeptide binding]; other site 573065007232 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 573065007233 UbiA prenyltransferase family; Region: UbiA; pfam01040 573065007234 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 573065007235 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 573065007236 Subunit III/VIIa interface [polypeptide binding]; other site 573065007237 Phospholipid binding site [chemical binding]; other site 573065007238 Subunit I/III interface [polypeptide binding]; other site 573065007239 Subunit III/VIb interface [polypeptide binding]; other site 573065007240 Subunit III/VIa interface; other site 573065007241 Subunit III/Vb interface [polypeptide binding]; other site 573065007242 Protein of unknown function (DUF983); Region: DUF983; cl02211 573065007243 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 573065007244 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573065007245 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573065007246 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573065007247 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 573065007248 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 573065007249 putative active site [active] 573065007250 catalytic site [active] 573065007251 putative metal binding site [ion binding]; other site 573065007252 hypothetical protein; Validated; Region: PRK00228 573065007253 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 573065007254 catalytic triad [active] 573065007255 dimer interface [polypeptide binding]; other site 573065007256 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 573065007257 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 573065007258 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 573065007259 active site 573065007260 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 573065007261 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 573065007262 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573065007263 DNA binding residues [nucleotide binding] 573065007264 putative dimer interface [polypeptide binding]; other site 573065007265 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 573065007266 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573065007267 active site 573065007268 nucleotide binding site [chemical binding]; other site 573065007269 HIGH motif; other site 573065007270 KMSKS motif; other site 573065007271 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573065007272 Beta-lactamase; Region: Beta-lactamase; pfam00144 573065007273 Predicted transcriptional regulator [Transcription]; Region: COG2932 573065007274 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573065007275 Catalytic site [active] 573065007276 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573065007277 CoenzymeA binding site [chemical binding]; other site 573065007278 subunit interaction site [polypeptide binding]; other site 573065007279 PHB binding site; other site 573065007280 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573065007281 CoenzymeA binding site [chemical binding]; other site 573065007282 subunit interaction site [polypeptide binding]; other site 573065007283 PHB binding site; other site 573065007284 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 573065007285 Ligand Binding Site [chemical binding]; other site 573065007286 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 573065007287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065007288 FeS/SAM binding site; other site 573065007289 exopolyphosphatase; Region: exo_poly_only; TIGR03706 573065007290 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 573065007291 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 573065007292 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 573065007293 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 573065007294 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573065007295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573065007296 aspartate aminotransferase; Provisional; Region: PRK05764 573065007297 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573065007298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065007299 homodimer interface [polypeptide binding]; other site 573065007300 catalytic residue [active] 573065007301 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 573065007302 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 573065007303 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 573065007304 active site 573065007305 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 573065007306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065007307 S-adenosylmethionine binding site [chemical binding]; other site 573065007308 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 573065007309 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 573065007310 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573065007311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 573065007312 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 573065007313 active site 573065007314 MAPEG family; Region: MAPEG; cl09190 573065007315 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 573065007316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065007317 S-adenosylmethionine binding site [chemical binding]; other site 573065007318 GMP synthase; Reviewed; Region: guaA; PRK00074 573065007319 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 573065007320 AMP/PPi binding site [chemical binding]; other site 573065007321 candidate oxyanion hole; other site 573065007322 catalytic triad [active] 573065007323 potential glutamine specificity residues [chemical binding]; other site 573065007324 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 573065007325 ATP Binding subdomain [chemical binding]; other site 573065007326 Ligand Binding sites [chemical binding]; other site 573065007327 Dimerization subdomain; other site 573065007328 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 573065007329 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 573065007330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065007331 Walker A motif; other site 573065007332 ATP binding site [chemical binding]; other site 573065007333 Walker B motif; other site 573065007334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 573065007335 Integrase core domain; Region: rve; pfam00665 573065007336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 573065007337 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 573065007338 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573065007339 active site 573065007340 Int/Topo IB signature motif; other site 573065007341 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 573065007342 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 573065007343 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 573065007344 ATP binding site [chemical binding]; other site 573065007345 Walker A motif; other site 573065007346 hexamer interface [polypeptide binding]; other site 573065007347 Walker B motif; other site 573065007348 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 573065007349 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 573065007350 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 573065007351 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 573065007352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065007353 Walker B; other site 573065007354 D-loop; other site 573065007355 H-loop/switch region; other site 573065007356 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 573065007357 conjugal transfer protein TrbL; Provisional; Region: PRK13875 573065007358 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 573065007359 conjugal transfer protein TrbF; Provisional; Region: PRK13872 573065007360 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 573065007361 VirB7 interaction site; other site 573065007362 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 573065007363 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 573065007364 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573065007365 DNA-binding site [nucleotide binding]; DNA binding site 573065007366 RNA-binding motif; other site 573065007367 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 573065007368 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 573065007369 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 573065007370 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573065007371 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 573065007372 active site 573065007373 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 573065007374 active site 573065007375 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573065007376 active site 573065007377 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 573065007378 putative substrate binding site [chemical binding]; other site 573065007379 active site 573065007380 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 573065007381 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 573065007382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573065007383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573065007384 dimerization interface [polypeptide binding]; other site 573065007385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065007386 dimer interface [polypeptide binding]; other site 573065007387 phosphorylation site [posttranslational modification] 573065007388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065007389 Mg2+ binding site [ion binding]; other site 573065007390 G-X-G motif; other site 573065007391 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573065007392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065007393 active site 573065007394 phosphorylation site [posttranslational modification] 573065007395 intermolecular recognition site; other site 573065007396 dimerization interface [polypeptide binding]; other site 573065007397 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 573065007398 DNA binding site [nucleotide binding] 573065007399 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 573065007400 ArsC family; Region: ArsC; pfam03960 573065007401 putative catalytic residues [active] 573065007402 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 573065007403 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065007404 DNA binding residues [nucleotide binding] 573065007405 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 573065007406 active site 573065007407 oligomerization interface [polypeptide binding]; other site 573065007408 metal binding site [ion binding]; metal-binding site 573065007409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 573065007410 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 573065007411 Trp docking motif [polypeptide binding]; other site 573065007412 active site 573065007413 PQQ-like domain; Region: PQQ_2; pfam13360 573065007414 GTP-binding protein Der; Reviewed; Region: PRK00093 573065007415 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 573065007416 G1 box; other site 573065007417 GTP/Mg2+ binding site [chemical binding]; other site 573065007418 Switch I region; other site 573065007419 G2 box; other site 573065007420 Switch II region; other site 573065007421 G3 box; other site 573065007422 G4 box; other site 573065007423 G5 box; other site 573065007424 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 573065007425 G1 box; other site 573065007426 GTP/Mg2+ binding site [chemical binding]; other site 573065007427 Switch I region; other site 573065007428 G2 box; other site 573065007429 G3 box; other site 573065007430 Switch II region; other site 573065007431 G4 box; other site 573065007432 G5 box; other site 573065007433 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 573065007434 L-lysine aminotransferase; Provisional; Region: PRK08297 573065007435 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573065007436 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573065007437 catalytic residue [active] 573065007438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065007439 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 573065007440 NAD(P) binding site [chemical binding]; other site 573065007441 active site 573065007442 amidophosphoribosyltransferase; Provisional; Region: PRK09123 573065007443 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 573065007444 active site 573065007445 tetramer interface [polypeptide binding]; other site 573065007446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573065007447 active site 573065007448 Colicin V production protein; Region: Colicin_V; pfam02674 573065007449 DNA repair protein RadA; Provisional; Region: PRK11823 573065007450 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573065007451 Walker A motif; other site 573065007452 ATP binding site [chemical binding]; other site 573065007453 Walker B motif; other site 573065007454 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573065007455 replicative DNA helicase; Provisional; Region: PRK09165 573065007456 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 573065007457 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 573065007458 Walker A motif; other site 573065007459 ATP binding site [chemical binding]; other site 573065007460 Walker B motif; other site 573065007461 DNA binding loops [nucleotide binding] 573065007462 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 573065007463 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 573065007464 Active site serine [active] 573065007465 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 573065007466 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065007467 N-terminal plug; other site 573065007468 ligand-binding site [chemical binding]; other site 573065007469 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 573065007470 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 573065007471 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 573065007472 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573065007473 Methyltransferase domain; Region: Methyltransf_11; pfam08241 573065007474 S-adenosylmethionine binding site [chemical binding]; other site 573065007475 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 573065007476 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 573065007477 trigger factor; Provisional; Region: tig; PRK01490 573065007478 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573065007479 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 573065007480 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 573065007481 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 573065007482 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 573065007483 oligomer interface [polypeptide binding]; other site 573065007484 active site residues [active] 573065007485 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573065007486 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 573065007487 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 573065007488 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 573065007489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065007490 Walker A motif; other site 573065007491 ATP binding site [chemical binding]; other site 573065007492 Walker B motif; other site 573065007493 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573065007494 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573065007495 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 573065007496 Class I aldolases; Region: Aldolase_Class_I; cd00945 573065007497 catalytic residue [active] 573065007498 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065007499 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065007500 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065007501 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065007502 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 573065007503 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065007504 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065007505 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065007506 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573065007507 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 573065007508 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573065007509 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 573065007510 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 573065007511 Uncharacterized conserved protein [Function unknown]; Region: COG3538 573065007512 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 573065007513 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 573065007514 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 573065007515 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 573065007516 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 573065007517 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 573065007518 Fn3 associated; Region: Fn3_assoc; pfam13287 573065007519 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 573065007520 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573065007521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065007522 DNA-binding site [nucleotide binding]; DNA binding site 573065007523 UTRA domain; Region: UTRA; pfam07702 573065007524 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 573065007525 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 573065007526 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 573065007527 active site 573065007528 HIGH motif; other site 573065007529 KMSKS motif; other site 573065007530 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 573065007531 tRNA binding surface [nucleotide binding]; other site 573065007532 anticodon binding site; other site 573065007533 Protein of unknown function (DUF805); Region: DUF805; pfam05656 573065007534 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 573065007535 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 573065007536 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573065007537 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573065007538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065007539 S-adenosylmethionine binding site [chemical binding]; other site 573065007540 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 573065007541 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 573065007542 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065007543 Protein of unknown function (DUF805); Region: DUF805; pfam05656 573065007544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 573065007545 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 573065007546 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573065007547 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065007548 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 573065007549 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573065007550 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 573065007551 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 573065007552 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 573065007553 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 573065007554 putative homodimer interface [polypeptide binding]; other site 573065007555 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 573065007556 heterodimer interface [polypeptide binding]; other site 573065007557 homodimer interface [polypeptide binding]; other site 573065007558 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 573065007559 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 573065007560 23S rRNA interface [nucleotide binding]; other site 573065007561 L7/L12 interface [polypeptide binding]; other site 573065007562 putative thiostrepton binding site; other site 573065007563 L25 interface [polypeptide binding]; other site 573065007564 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 573065007565 mRNA/rRNA interface [nucleotide binding]; other site 573065007566 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 573065007567 active site 573065007568 dinuclear metal binding site [ion binding]; other site 573065007569 dimerization interface [polypeptide binding]; other site 573065007570 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 573065007571 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 573065007572 conserved cys residue [active] 573065007573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573065007574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573065007575 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 573065007576 23S rRNA interface [nucleotide binding]; other site 573065007577 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 573065007578 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 573065007579 peripheral dimer interface [polypeptide binding]; other site 573065007580 core dimer interface [polypeptide binding]; other site 573065007581 L10 interface [polypeptide binding]; other site 573065007582 L11 interface [polypeptide binding]; other site 573065007583 putative EF-Tu interaction site [polypeptide binding]; other site 573065007584 putative EF-G interaction site [polypeptide binding]; other site 573065007585 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 573065007586 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 573065007587 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 573065007588 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573065007589 Peptidase family M23; Region: Peptidase_M23; pfam01551 573065007590 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 573065007591 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 573065007592 catalytic triad [active] 573065007593 Protein of unknown function; Region: DUF3971; pfam13116 573065007594 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 573065007595 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 573065007596 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 573065007597 active site 573065007598 HIGH motif; other site 573065007599 dimer interface [polypeptide binding]; other site 573065007600 KMSKS motif; other site 573065007601 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 573065007602 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 573065007603 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 573065007604 Transcriptional regulator; Region: Rrf2; cl17282 573065007605 Rrf2 family protein; Region: rrf2_super; TIGR00738 573065007606 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 573065007607 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 573065007608 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573065007609 catalytic residue [active] 573065007610 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 573065007611 putative ABC transporter; Region: ycf24; CHL00085 573065007612 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 573065007613 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 573065007614 Walker A/P-loop; other site 573065007615 ATP binding site [chemical binding]; other site 573065007616 Q-loop/lid; other site 573065007617 ABC transporter signature motif; other site 573065007618 Walker B; other site 573065007619 D-loop; other site 573065007620 H-loop/switch region; other site 573065007621 FeS assembly protein SufD; Region: sufD; TIGR01981 573065007622 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 573065007623 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 573065007624 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 573065007625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573065007626 catalytic residue [active] 573065007627 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 573065007628 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 573065007629 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573065007630 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573065007631 putative acyl-acceptor binding pocket; other site 573065007632 Clusterin-associated protein-1; Region: Cluap1; pfam10234 573065007633 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573065007634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573065007635 metal binding site [ion binding]; metal-binding site 573065007636 active site 573065007637 I-site; other site 573065007638 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573065007639 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573065007640 ATP binding site [chemical binding]; other site 573065007641 Mg++ binding site [ion binding]; other site 573065007642 motif III; other site 573065007643 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573065007644 nucleotide binding region [chemical binding]; other site 573065007645 ATP-binding site [chemical binding]; other site 573065007646 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 573065007647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065007648 Mg2+ binding site [ion binding]; other site 573065007649 G-X-G motif; other site 573065007650 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573065007651 anchoring element; other site 573065007652 dimer interface [polypeptide binding]; other site 573065007653 ATP binding site [chemical binding]; other site 573065007654 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 573065007655 active site 573065007656 putative metal-binding site [ion binding]; other site 573065007657 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573065007658 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 573065007659 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 573065007660 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 573065007661 glutamine synthetase; Provisional; Region: glnA; PRK09469 573065007662 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 573065007663 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573065007664 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 573065007665 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573065007666 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065007667 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065007668 N-terminal plug; other site 573065007669 ligand-binding site [chemical binding]; other site 573065007670 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 573065007671 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 573065007672 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 573065007673 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 573065007674 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 573065007675 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 573065007676 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573065007677 catalytic triad [active] 573065007678 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 573065007679 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065007680 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573065007681 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065007682 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 573065007683 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 573065007684 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 573065007685 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 573065007686 homotetramer interface [polypeptide binding]; other site 573065007687 NAD(P) binding site [chemical binding]; other site 573065007688 homodimer interface [polypeptide binding]; other site 573065007689 active site 573065007690 acyl carrier protein; Provisional; Region: acpP; PRK00982 573065007691 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 573065007692 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 573065007693 dimer interface [polypeptide binding]; other site 573065007694 active site 573065007695 YceG-like family; Region: YceG; pfam02618 573065007696 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 573065007697 dimerization interface [polypeptide binding]; other site 573065007698 hypothetical protein; Provisional; Region: PRK11820 573065007699 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 573065007700 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 573065007701 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 573065007702 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 573065007703 catalytic site [active] 573065007704 G-X2-G-X-G-K; other site 573065007705 Cytochrome c2 [Energy production and conversion]; Region: COG3474 573065007706 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 573065007707 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 573065007708 tetramer interface [polypeptide binding]; other site 573065007709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065007710 catalytic residue [active] 573065007711 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 573065007712 Found in ATP-dependent protease La (LON); Region: LON; smart00464 573065007713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065007714 Walker A motif; other site 573065007715 ATP binding site [chemical binding]; other site 573065007716 Walker B motif; other site 573065007717 arginine finger; other site 573065007718 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573065007719 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573065007720 IHF dimer interface [polypeptide binding]; other site 573065007721 IHF - DNA interface [nucleotide binding]; other site 573065007722 Autotransporter beta-domain; Region: Autotransporter; smart00869 573065007723 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 573065007724 NADH dehydrogenase subunit B; Validated; Region: PRK06411 573065007725 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 573065007726 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 573065007727 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 573065007728 NADH dehydrogenase subunit D; Validated; Region: PRK06075 573065007729 NADH dehydrogenase subunit E; Validated; Region: PRK07539 573065007730 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573065007731 putative dimer interface [polypeptide binding]; other site 573065007732 [2Fe-2S] cluster binding site [ion binding]; other site 573065007733 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 573065007734 SLBB domain; Region: SLBB; pfam10531 573065007735 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 573065007736 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573065007737 TM2 domain; Region: TM2; pfam05154 573065007738 hypothetical protein; Provisional; Region: PHA03164 573065007739 NADH dehydrogenase subunit G; Validated; Region: PRK09130 573065007740 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573065007741 catalytic loop [active] 573065007742 iron binding site [ion binding]; other site 573065007743 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 573065007744 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 573065007745 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 573065007746 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 573065007747 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 573065007748 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 573065007749 4Fe-4S binding domain; Region: Fer4; pfam00037 573065007750 4Fe-4S binding domain; Region: Fer4; pfam00037 573065007751 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 573065007752 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 573065007753 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 573065007754 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 573065007755 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 573065007756 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 573065007757 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573065007758 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 573065007759 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573065007760 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 573065007761 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573065007762 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 573065007763 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 573065007764 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 573065007765 pantothenate kinase; Reviewed; Region: PRK13318 573065007766 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 573065007767 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 573065007768 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 573065007769 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 573065007770 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 573065007771 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 573065007772 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 573065007773 putative active site [active] 573065007774 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 573065007775 DHH family; Region: DHH; pfam01368 573065007776 DHHA1 domain; Region: DHHA1; pfam02272 573065007777 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573065007778 DNA-binding site [nucleotide binding]; DNA binding site 573065007779 RNA-binding motif; other site 573065007780 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573065007781 DNA-binding site [nucleotide binding]; DNA binding site 573065007782 RNA-binding motif; other site 573065007783 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 573065007784 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 573065007785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 573065007786 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 573065007787 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 573065007788 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 573065007789 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 573065007790 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 573065007791 23S rRNA interface [nucleotide binding]; other site 573065007792 L3 interface [polypeptide binding]; other site 573065007793 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 573065007794 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 573065007795 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573065007796 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 573065007797 prolyl-tRNA synthetase; Provisional; Region: PRK12325 573065007798 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 573065007799 dimer interface [polypeptide binding]; other site 573065007800 motif 1; other site 573065007801 active site 573065007802 motif 2; other site 573065007803 motif 3; other site 573065007804 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 573065007805 anticodon binding site; other site 573065007806 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 573065007807 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573065007808 FtsX-like permease family; Region: FtsX; pfam02687 573065007809 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573065007810 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573065007811 Walker A/P-loop; other site 573065007812 ATP binding site [chemical binding]; other site 573065007813 Q-loop/lid; other site 573065007814 ABC transporter signature motif; other site 573065007815 Walker B; other site 573065007816 D-loop; other site 573065007817 H-loop/switch region; other site 573065007818 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 573065007819 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 573065007820 putative active site [active] 573065007821 putative PHP Thumb interface [polypeptide binding]; other site 573065007822 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 573065007823 generic binding surface II; other site 573065007824 generic binding surface I; other site 573065007825 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 573065007826 rRNA interaction site [nucleotide binding]; other site 573065007827 S8 interaction site; other site 573065007828 putative laminin-1 binding site; other site 573065007829 elongation factor Ts; Provisional; Region: tsf; PRK09377 573065007830 UBA/TS-N domain; Region: UBA; pfam00627 573065007831 Elongation factor TS; Region: EF_TS; pfam00889 573065007832 Elongation factor TS; Region: EF_TS; pfam00889 573065007833 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 573065007834 putative nucleotide binding site [chemical binding]; other site 573065007835 uridine monophosphate binding site [chemical binding]; other site 573065007836 homohexameric interface [polypeptide binding]; other site 573065007837 ribosome recycling factor; Reviewed; Region: frr; PRK00083 573065007838 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 573065007839 hinge region; other site 573065007840 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 573065007841 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 573065007842 catalytic residue [active] 573065007843 putative FPP diphosphate binding site; other site 573065007844 putative FPP binding hydrophobic cleft; other site 573065007845 dimer interface [polypeptide binding]; other site 573065007846 putative IPP diphosphate binding site; other site 573065007847 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 573065007848 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 573065007849 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 573065007850 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 573065007851 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 573065007852 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 573065007853 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 573065007854 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 573065007855 active site 573065007856 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 573065007857 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 573065007858 putative substrate binding region [chemical binding]; other site 573065007859 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 573065007860 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573065007861 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573065007862 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573065007863 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573065007864 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573065007865 Surface antigen; Region: Bac_surface_Ag; pfam01103 573065007866 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 573065007867 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 573065007868 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 573065007869 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 573065007870 trimer interface [polypeptide binding]; other site 573065007871 active site 573065007872 UDP-GlcNAc binding site [chemical binding]; other site 573065007873 lipid binding site [chemical binding]; lipid-binding site 573065007874 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 573065007875 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 573065007876 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 573065007877 active site 573065007878 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 573065007879 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 573065007880 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 573065007881 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573065007882 Beta-lactamase; Region: Beta-lactamase; pfam00144 573065007883 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 573065007884 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 573065007885 dimer interface [polypeptide binding]; other site 573065007886 active site 573065007887 citrylCoA binding site [chemical binding]; other site 573065007888 NADH binding [chemical binding]; other site 573065007889 cationic pore residues; other site 573065007890 oxalacetate/citrate binding site [chemical binding]; other site 573065007891 coenzyme A binding site [chemical binding]; other site 573065007892 catalytic triad [active] 573065007893 LexA repressor; Validated; Region: PRK00215 573065007894 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 573065007895 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573065007896 Catalytic site [active] 573065007897 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 573065007898 active site 573065007899 ribulose/triose binding site [chemical binding]; other site 573065007900 phosphate binding site [ion binding]; other site 573065007901 substrate (anthranilate) binding pocket [chemical binding]; other site 573065007902 product (indole) binding pocket [chemical binding]; other site 573065007903 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 573065007904 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 573065007905 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 573065007906 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 573065007907 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 573065007908 glutamine binding [chemical binding]; other site 573065007909 catalytic triad [active] 573065007910 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 573065007911 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 573065007912 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 573065007913 HflX GTPase family; Region: HflX; cd01878 573065007914 G1 box; other site 573065007915 GTP/Mg2+ binding site [chemical binding]; other site 573065007916 Switch I region; other site 573065007917 G2 box; other site 573065007918 G3 box; other site 573065007919 Switch II region; other site 573065007920 G4 box; other site 573065007921 G5 box; other site 573065007922 bacterial Hfq-like; Region: Hfq; cd01716 573065007923 hexamer interface [polypeptide binding]; other site 573065007924 Sm1 motif; other site 573065007925 RNA binding site [nucleotide binding]; other site 573065007926 Sm2 motif; other site 573065007927 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 573065007928 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 573065007929 homodimer interface [polypeptide binding]; other site 573065007930 substrate-cofactor binding pocket; other site 573065007931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065007932 catalytic residue [active] 573065007933 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573065007934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065007935 active site 573065007936 phosphorylation site [posttranslational modification] 573065007937 intermolecular recognition site; other site 573065007938 dimerization interface [polypeptide binding]; other site 573065007939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065007940 Walker A motif; other site 573065007941 ATP binding site [chemical binding]; other site 573065007942 Walker B motif; other site 573065007943 arginine finger; other site 573065007944 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573065007945 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 573065007946 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573065007947 dimerization interface [polypeptide binding]; other site 573065007948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065007949 dimer interface [polypeptide binding]; other site 573065007950 phosphorylation site [posttranslational modification] 573065007951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065007952 ATP binding site [chemical binding]; other site 573065007953 Mg2+ binding site [ion binding]; other site 573065007954 G-X-G motif; other site 573065007955 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 573065007956 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573065007957 FMN binding site [chemical binding]; other site 573065007958 active site 573065007959 catalytic residues [active] 573065007960 substrate binding site [chemical binding]; other site 573065007961 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 573065007962 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 573065007963 substrate binding site; other site 573065007964 dimer interface; other site 573065007965 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 573065007966 homotrimer interaction site [polypeptide binding]; other site 573065007967 zinc binding site [ion binding]; other site 573065007968 CDP-binding sites; other site 573065007969 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 573065007970 putative hydrolase; Provisional; Region: PRK02113 573065007971 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 573065007972 active site 573065007973 DNA polymerase III subunit delta'; Validated; Region: PRK07471 573065007974 DNA polymerase III subunit delta'; Validated; Region: PRK08485 573065007975 thymidylate kinase; Validated; Region: tmk; PRK00698 573065007976 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 573065007977 TMP-binding site; other site 573065007978 ATP-binding site [chemical binding]; other site 573065007979 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 573065007980 rare lipoprotein A; Region: rlpA; TIGR00413 573065007981 Sporulation related domain; Region: SPOR; pfam05036 573065007982 Predicted membrane protein [Function unknown]; Region: COG3759 573065007983 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 573065007984 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 573065007985 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 573065007986 CPxP motif; other site 573065007987 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 573065007988 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 573065007989 metal binding site [ion binding]; metal-binding site 573065007990 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 573065007991 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 573065007992 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573065007993 ATP binding site [chemical binding]; other site 573065007994 putative Mg++ binding site [ion binding]; other site 573065007995 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573065007996 nucleotide binding region [chemical binding]; other site 573065007997 ATP-binding site [chemical binding]; other site 573065007998 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 573065007999 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 573065008000 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 573065008001 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 573065008002 generic binding surface II; other site 573065008003 ssDNA binding site; other site 573065008004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573065008005 ATP binding site [chemical binding]; other site 573065008006 putative Mg++ binding site [ion binding]; other site 573065008007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573065008008 nucleotide binding region [chemical binding]; other site 573065008009 ATP-binding site [chemical binding]; other site 573065008010 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 573065008011 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 573065008012 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 573065008013 putative acyl-acceptor binding pocket; other site 573065008014 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573065008015 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 573065008016 putative metal binding site; other site 573065008017 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 573065008018 DNA photolyase; Region: DNA_photolyase; pfam00875 573065008019 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 573065008020 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 573065008021 active site residue [active] 573065008022 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 573065008023 active site residue [active] 573065008024 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 573065008025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573065008026 substrate binding pocket [chemical binding]; other site 573065008027 membrane-bound complex binding site; other site 573065008028 hinge residues; other site 573065008029 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 573065008030 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 573065008031 homotrimer interaction site [polypeptide binding]; other site 573065008032 putative active site [active] 573065008033 CTP synthetase; Validated; Region: pyrG; PRK05380 573065008034 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 573065008035 Catalytic site [active] 573065008036 active site 573065008037 UTP binding site [chemical binding]; other site 573065008038 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 573065008039 active site 573065008040 putative oxyanion hole; other site 573065008041 catalytic triad [active] 573065008042 Preprotein translocase SecG subunit; Region: SecG; pfam03840 573065008043 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 573065008044 triosephosphate isomerase; Provisional; Region: PRK14565 573065008045 substrate binding site [chemical binding]; other site 573065008046 dimer interface [polypeptide binding]; other site 573065008047 catalytic triad [active] 573065008048 SurA N-terminal domain; Region: SurA_N_3; cl07813 573065008049 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 573065008050 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 573065008051 anthranilate synthase component I; Provisional; Region: PRK13573 573065008052 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 573065008053 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 573065008054 putative cation:proton antiport protein; Provisional; Region: PRK10669 573065008055 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 573065008056 TrkA-N domain; Region: TrkA_N; pfam02254 573065008057 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 573065008058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065008059 putative substrate translocation pore; other site 573065008060 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 573065008061 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 573065008062 homodimer interface [polypeptide binding]; other site 573065008063 metal binding site [ion binding]; metal-binding site 573065008064 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 573065008065 homodimer interface [polypeptide binding]; other site 573065008066 active site 573065008067 putative chemical substrate binding site [chemical binding]; other site 573065008068 metal binding site [ion binding]; metal-binding site 573065008069 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 573065008070 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 573065008071 Predicted transcriptional regulators [Transcription]; Region: COG1733 573065008072 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 573065008073 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573065008074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065008075 Walker A/P-loop; other site 573065008076 ATP binding site [chemical binding]; other site 573065008077 Q-loop/lid; other site 573065008078 ABC transporter signature motif; other site 573065008079 Walker B; other site 573065008080 D-loop; other site 573065008081 H-loop/switch region; other site 573065008082 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 573065008083 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 573065008084 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 573065008085 Competence-damaged protein; Region: CinA; pfam02464 573065008086 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 573065008087 putative coenzyme Q binding site [chemical binding]; other site 573065008088 lipoyl synthase; Provisional; Region: PRK05481 573065008089 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573065008090 FeS/SAM binding site; other site 573065008091 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 573065008092 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 573065008093 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573065008094 acyl-activating enzyme (AAE) consensus motif; other site 573065008095 AMP binding site [chemical binding]; other site 573065008096 active site 573065008097 CoA binding site [chemical binding]; other site 573065008098 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065008099 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065008100 N-terminal plug; other site 573065008101 ligand-binding site [chemical binding]; other site 573065008102 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 573065008103 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 573065008104 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 573065008105 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 573065008106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573065008107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573065008108 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573065008109 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 573065008110 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573065008111 E3 interaction surface; other site 573065008112 lipoyl attachment site [posttranslational modification]; other site 573065008113 e3 binding domain; Region: E3_binding; pfam02817 573065008114 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 573065008115 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 573065008116 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573065008117 E3 interaction surface; other site 573065008118 lipoyl attachment site [posttranslational modification]; other site 573065008119 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 573065008120 alpha subunit interface [polypeptide binding]; other site 573065008121 TPP binding site [chemical binding]; other site 573065008122 heterodimer interface [polypeptide binding]; other site 573065008123 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573065008124 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 573065008125 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 573065008126 tetramer interface [polypeptide binding]; other site 573065008127 TPP-binding site [chemical binding]; other site 573065008128 heterodimer interface [polypeptide binding]; other site 573065008129 phosphorylation loop region [posttranslational modification] 573065008130 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 573065008131 Septum formation initiator; Region: DivIC; pfam04977 573065008132 enolase; Provisional; Region: eno; PRK00077 573065008133 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 573065008134 dimer interface [polypeptide binding]; other site 573065008135 metal binding site [ion binding]; metal-binding site 573065008136 substrate binding pocket [chemical binding]; other site 573065008137 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 573065008138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573065008139 motif II; other site 573065008140 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 573065008141 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 573065008142 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573065008143 DNA binding residues [nucleotide binding] 573065008144 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573065008145 IHF dimer interface [polypeptide binding]; other site 573065008146 IHF - DNA interface [nucleotide binding]; other site 573065008147 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 573065008148 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 573065008149 dimer interface [polypeptide binding]; other site 573065008150 active site 573065008151 CoA binding pocket [chemical binding]; other site 573065008152 putative phosphate acyltransferase; Provisional; Region: PRK05331 573065008153 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 573065008154 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 573065008155 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 573065008156 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 573065008157 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 573065008158 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 573065008159 thiamine-monophosphate kinase; Region: thiL; TIGR01379 573065008160 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 573065008161 ATP binding site [chemical binding]; other site 573065008162 dimerization interface [polypeptide binding]; other site 573065008163 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 573065008164 putative RNA binding site [nucleotide binding]; other site 573065008165 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 573065008166 homopentamer interface [polypeptide binding]; other site 573065008167 active site 573065008168 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 573065008169 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 573065008170 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 573065008171 active site 573065008172 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 573065008173 Lumazine binding domain; Region: Lum_binding; pfam00677 573065008174 Lumazine binding domain; Region: Lum_binding; pfam00677 573065008175 RibD C-terminal domain; Region: RibD_C; cl17279 573065008176 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 573065008177 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 573065008178 ATP cone domain; Region: ATP-cone; pfam03477 573065008179 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 573065008180 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 573065008181 dimer interface [polypeptide binding]; other site 573065008182 active site 573065008183 glycine-pyridoxal phosphate binding site [chemical binding]; other site 573065008184 folate binding site [chemical binding]; other site 573065008185 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 573065008186 Putative addiction module component; Region: Unstab_antitox; pfam09720 573065008187 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 573065008188 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 573065008189 substrate-cofactor binding pocket; other site 573065008190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065008191 catalytic residue [active] 573065008192 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 573065008193 dimer interface [polypeptide binding]; other site 573065008194 allosteric magnesium binding site [ion binding]; other site 573065008195 active site 573065008196 aspartate-rich active site metal binding site; other site 573065008197 Schiff base residues; other site 573065008198 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 573065008199 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573065008200 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 573065008201 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 573065008202 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573065008203 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573065008204 ligand binding site [chemical binding]; other site 573065008205 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 573065008206 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 573065008207 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 573065008208 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 573065008209 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 573065008210 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 573065008211 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573065008212 CAP-like domain; other site 573065008213 active site 573065008214 primary dimer interface [polypeptide binding]; other site 573065008215 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573065008216 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 573065008217 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 573065008218 Recombination protein O N terminal; Region: RecO_N; pfam11967 573065008219 Recombination protein O C terminal; Region: RecO_C; pfam02565 573065008220 GTPase Era; Reviewed; Region: era; PRK00089 573065008221 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 573065008222 G1 box; other site 573065008223 GTP/Mg2+ binding site [chemical binding]; other site 573065008224 Switch I region; other site 573065008225 G2 box; other site 573065008226 Switch II region; other site 573065008227 G3 box; other site 573065008228 G4 box; other site 573065008229 G5 box; other site 573065008230 KH domain; Region: KH_2; pfam07650 573065008231 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 573065008232 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 573065008233 dimerization interface [polypeptide binding]; other site 573065008234 active site 573065008235 metal binding site [ion binding]; metal-binding site 573065008236 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 573065008237 dsRNA binding site [nucleotide binding]; other site 573065008238 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 573065008239 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573065008240 Catalytic site [active] 573065008241 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573065008242 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 573065008243 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 573065008244 active site 573065008245 hydrophilic channel; other site 573065008246 dimerization interface [polypeptide binding]; other site 573065008247 catalytic residues [active] 573065008248 active site lid [active] 573065008249 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573065008250 active site 573065008251 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 573065008252 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573065008253 Zn2+ binding site [ion binding]; other site 573065008254 Mg2+ binding site [ion binding]; other site 573065008255 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573065008256 synthetase active site [active] 573065008257 NTP binding site [chemical binding]; other site 573065008258 metal binding site [ion binding]; metal-binding site 573065008259 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 573065008260 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 573065008261 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 573065008262 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 573065008263 EamA-like transporter family; Region: EamA; pfam00892 573065008264 EamA-like transporter family; Region: EamA; pfam00892 573065008265 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 573065008266 catalytic center binding site [active] 573065008267 ATP binding site [chemical binding]; other site 573065008268 Uncharacterized conserved protein [Function unknown]; Region: COG1432 573065008269 LabA_like proteins; Region: LabA; cd10911 573065008270 putative metal binding site [ion binding]; other site 573065008271 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 573065008272 SmpB-tmRNA interface; other site 573065008273 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573065008274 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 573065008275 dimer interface [polypeptide binding]; other site 573065008276 active site 573065008277 catalytic residue [active] 573065008278 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573065008279 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573065008280 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573065008281 catalytic residue [active] 573065008282 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573065008283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065008284 Walker A/P-loop; other site 573065008285 ATP binding site [chemical binding]; other site 573065008286 Q-loop/lid; other site 573065008287 ABC transporter signature motif; other site 573065008288 Walker B; other site 573065008289 D-loop; other site 573065008290 H-loop/switch region; other site 573065008291 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573065008292 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573065008293 ABC-ATPase subunit interface; other site 573065008294 dimer interface [polypeptide binding]; other site 573065008295 putative PBP binding regions; other site 573065008296 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 573065008297 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573065008298 intersubunit interface [polypeptide binding]; other site 573065008299 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 573065008300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065008301 S-adenosylmethionine binding site [chemical binding]; other site 573065008302 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 573065008303 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 573065008304 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573065008305 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 573065008306 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 573065008307 putative C-terminal domain interface [polypeptide binding]; other site 573065008308 putative GSH binding site (G-site) [chemical binding]; other site 573065008309 putative dimer interface [polypeptide binding]; other site 573065008310 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 573065008311 putative N-terminal domain interface [polypeptide binding]; other site 573065008312 putative dimer interface [polypeptide binding]; other site 573065008313 putative substrate binding pocket (H-site) [chemical binding]; other site 573065008314 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 573065008315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573065008316 ATP binding site [chemical binding]; other site 573065008317 putative Mg++ binding site [ion binding]; other site 573065008318 nucleotide binding region [chemical binding]; other site 573065008319 helicase superfamily c-terminal domain; Region: HELICc; smart00490 573065008320 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 573065008321 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 573065008322 amino acid transporter; Region: 2A0306; TIGR00909 573065008323 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 573065008324 SCP-2 sterol transfer family; Region: SCP2; pfam02036 573065008325 Predicted flavoproteins [General function prediction only]; Region: COG2081 573065008326 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 573065008327 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 573065008328 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 573065008329 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 573065008330 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 573065008331 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 573065008332 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 573065008333 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 573065008334 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 573065008335 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 573065008336 DNA binding site [nucleotide binding] 573065008337 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 573065008338 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 573065008339 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 573065008340 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 573065008341 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 573065008342 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 573065008343 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 573065008344 RPB1 interaction site [polypeptide binding]; other site 573065008345 RPB11 interaction site [polypeptide binding]; other site 573065008346 RPB10 interaction site [polypeptide binding]; other site 573065008347 RPB3 interaction site [polypeptide binding]; other site 573065008348 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 573065008349 peptide chain release factor 2; Validated; Region: prfB; PRK00578 573065008350 This domain is found in peptide chain release factors; Region: PCRF; smart00937 573065008351 RF-1 domain; Region: RF-1; pfam00472 573065008352 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 573065008353 Transglycosylase; Region: Transgly; pfam00912 573065008354 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573065008355 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 573065008356 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573065008357 active site 573065008358 metal binding site [ion binding]; metal-binding site 573065008359 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 573065008360 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 573065008361 homodimer interface [polypeptide binding]; other site 573065008362 oligonucleotide binding site [chemical binding]; other site 573065008363 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 573065008364 Peptidase family M48; Region: Peptidase_M48; cl12018 573065008365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065008366 binding surface 573065008367 TPR motif; other site 573065008368 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573065008369 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 573065008370 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 573065008371 ThiS interaction site; other site 573065008372 putative active site [active] 573065008373 tetramer interface [polypeptide binding]; other site 573065008374 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 573065008375 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 573065008376 putative active site [active] 573065008377 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 573065008378 thiS-thiF/thiG interaction site; other site 573065008379 Dehydroquinase class II; Region: DHquinase_II; pfam01220 573065008380 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 573065008381 trimer interface [polypeptide binding]; other site 573065008382 active site 573065008383 dimer interface [polypeptide binding]; other site 573065008384 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 573065008385 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573065008386 carboxyltransferase (CT) interaction site; other site 573065008387 biotinylation site [posttranslational modification]; other site 573065008388 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 573065008389 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573065008390 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 573065008391 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 573065008392 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 573065008393 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 573065008394 NADH dehydrogenase; Validated; Region: PRK08183 573065008395 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 573065008396 TSCPD domain; Region: TSCPD; pfam12637 573065008397 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 573065008398 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573065008399 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573065008400 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573065008401 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 573065008402 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 573065008403 dimer interface [polypeptide binding]; other site 573065008404 anticodon binding site; other site 573065008405 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 573065008406 homodimer interface [polypeptide binding]; other site 573065008407 motif 1; other site 573065008408 active site 573065008409 motif 2; other site 573065008410 GAD domain; Region: GAD; pfam02938 573065008411 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573065008412 active site 573065008413 motif 3; other site 573065008414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 573065008415 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 573065008416 Walker A motif; other site 573065008417 ATP binding site [chemical binding]; other site 573065008418 polyphosphate kinase; Provisional; Region: PRK05443 573065008419 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 573065008420 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 573065008421 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 573065008422 putative domain interface [polypeptide binding]; other site 573065008423 putative active site [active] 573065008424 catalytic site [active] 573065008425 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 573065008426 putative domain interface [polypeptide binding]; other site 573065008427 putative active site [active] 573065008428 catalytic site [active] 573065008429 exopolyphosphatase; Region: exo_poly_only; TIGR03706 573065008430 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 573065008431 Peptidase S46; Region: Peptidase_S46; pfam10459 573065008432 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573065008433 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573065008434 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 573065008435 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 573065008436 active site 573065008437 substrate binding site [chemical binding]; other site 573065008438 cosubstrate binding site; other site 573065008439 catalytic site [active] 573065008440 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 573065008441 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 573065008442 dimerization interface [polypeptide binding]; other site 573065008443 putative ATP binding site [chemical binding]; other site 573065008444 ribonuclease D; Region: rnd; TIGR01388 573065008445 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 573065008446 catalytic site [active] 573065008447 putative active site [active] 573065008448 putative substrate binding site [chemical binding]; other site 573065008449 HRDC domain; Region: HRDC; pfam00570 573065008450 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 573065008451 active site 573065008452 multimer interface [polypeptide binding]; other site 573065008453 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573065008454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065008455 Walker A/P-loop; other site 573065008456 ATP binding site [chemical binding]; other site 573065008457 Q-loop/lid; other site 573065008458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065008459 ABC transporter signature motif; other site 573065008460 Walker B; other site 573065008461 D-loop; other site 573065008462 H-loop/switch region; other site 573065008463 ABC transporter; Region: ABC_tran_2; pfam12848 573065008464 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573065008465 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 573065008466 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 573065008467 multifunctional aminopeptidase A; Provisional; Region: PRK00913 573065008468 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 573065008469 interface (dimer of trimers) [polypeptide binding]; other site 573065008470 Substrate-binding/catalytic site; other site 573065008471 Zn-binding sites [ion binding]; other site 573065008472 Predicted permeases [General function prediction only]; Region: COG0795 573065008473 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 573065008474 Predicted permeases [General function prediction only]; Region: COG0795 573065008475 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 573065008476 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 573065008477 OstA-like protein; Region: OstA; cl00844 573065008478 Organic solvent tolerance protein; Region: OstA_C; pfam04453 573065008479 SurA N-terminal domain; Region: SurA_N; pfam09312 573065008480 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573065008481 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 573065008482 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 573065008483 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 573065008484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065008485 S-adenosylmethionine binding site [chemical binding]; other site 573065008486 aldolase II superfamily protein; Provisional; Region: PRK07044 573065008487 intersubunit interface [polypeptide binding]; other site 573065008488 active site 573065008489 Zn2+ binding site [ion binding]; other site 573065008490 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 573065008491 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573065008492 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 573065008493 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 573065008494 nudix motif; other site 573065008495 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 573065008496 FAD binding domain; Region: FAD_binding_4; pfam01565 573065008497 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573065008498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065008499 active site 573065008500 phosphorylation site [posttranslational modification] 573065008501 intermolecular recognition site; other site 573065008502 dimerization interface [polypeptide binding]; other site 573065008503 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573065008504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065008505 active site 573065008506 phosphorylation site [posttranslational modification] 573065008507 intermolecular recognition site; other site 573065008508 dimerization interface [polypeptide binding]; other site 573065008509 Protein of unknown function (DUF328); Region: DUF328; pfam03883 573065008510 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 573065008511 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 573065008512 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 573065008513 YceI-like domain; Region: YceI; pfam04264 573065008514 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 573065008515 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 573065008516 active site 573065008517 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 573065008518 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573065008519 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 573065008520 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065008521 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 573065008522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065008523 Coenzyme A binding pocket [chemical binding]; other site 573065008524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573065008525 Transposase; Region: HTH_Tnp_1; pfam01527 573065008526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573065008527 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573065008528 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573065008529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573065008530 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573065008531 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573065008532 Phasin protein; Region: Phasin_2; cl11491 573065008533 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 573065008534 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 573065008535 Sporulation related domain; Region: SPOR; pfam05036 573065008536 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573065008537 HSP70 interaction site [polypeptide binding]; other site 573065008538 ATPase MipZ; Region: MipZ; pfam09140 573065008539 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573065008540 P-loop; other site 573065008541 Magnesium ion binding site [ion binding]; other site 573065008542 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 573065008543 active site 573065008544 hypothetical protein; Reviewed; Region: PRK00024 573065008545 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 573065008546 MPN+ (JAMM) motif; other site 573065008547 Zinc-binding site [ion binding]; other site 573065008548 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 573065008549 TMAO/DMSO reductase; Reviewed; Region: PRK05363 573065008550 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 573065008551 Moco binding site; other site 573065008552 metal coordination site [ion binding]; other site 573065008553 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 573065008554 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 573065008555 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573065008556 adenylosuccinate lyase; Provisional; Region: PRK07492 573065008557 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 573065008558 tetramer interface [polypeptide binding]; other site 573065008559 active site 573065008560 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 573065008561 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 573065008562 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 573065008563 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 573065008564 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 573065008565 ATP binding site [chemical binding]; other site 573065008566 active site 573065008567 substrate binding site [chemical binding]; other site 573065008568 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 573065008569 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 573065008570 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 573065008571 putative active site [active] 573065008572 catalytic triad [active] 573065008573 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 573065008574 TAP-like protein; Region: Abhydrolase_4; pfam08386 573065008575 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 573065008576 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 573065008577 dimerization interface [polypeptide binding]; other site 573065008578 ATP binding site [chemical binding]; other site 573065008579 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 573065008580 dimerization interface [polypeptide binding]; other site 573065008581 ATP binding site [chemical binding]; other site 573065008582 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573065008583 Sel1-like repeats; Region: SEL1; smart00671 573065008584 Sel1-like repeats; Region: SEL1; smart00671 573065008585 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 573065008586 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 573065008587 active site 573065008588 catalytic tetrad [active] 573065008589 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 573065008590 putative GSH binding site [chemical binding]; other site 573065008591 catalytic residues [active] 573065008592 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 573065008593 TPR repeat; Region: TPR_11; pfam13414 573065008594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065008595 TPR motif; other site 573065008596 binding surface 573065008597 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 573065008598 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 573065008599 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573065008600 RNA binding surface [nucleotide binding]; other site 573065008601 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573065008602 Domain of unknown function DUF21; Region: DUF21; pfam01595 573065008603 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573065008604 Transporter associated domain; Region: CorC_HlyC; smart01091 573065008605 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 573065008606 S-formylglutathione hydrolase; Region: PLN02442 573065008607 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573065008608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065008609 Coenzyme A binding pocket [chemical binding]; other site 573065008610 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 573065008611 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 573065008612 substrate binding site [chemical binding]; other site 573065008613 catalytic Zn binding site [ion binding]; other site 573065008614 NAD binding site [chemical binding]; other site 573065008615 structural Zn binding site [ion binding]; other site 573065008616 dimer interface [polypeptide binding]; other site 573065008617 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573065008618 HAMP domain; Region: HAMP; pfam00672 573065008619 dimerization interface [polypeptide binding]; other site 573065008620 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065008621 dimer interface [polypeptide binding]; other site 573065008622 putative CheW interface [polypeptide binding]; other site 573065008623 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 573065008624 ligand binding site [chemical binding]; other site 573065008625 active site 573065008626 UGI interface [polypeptide binding]; other site 573065008627 catalytic site [active] 573065008628 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 573065008629 E-class dimer interface [polypeptide binding]; other site 573065008630 P-class dimer interface [polypeptide binding]; other site 573065008631 active site 573065008632 Cu2+ binding site [ion binding]; other site 573065008633 Zn2+ binding site [ion binding]; other site 573065008634 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573065008635 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573065008636 active site 573065008637 Peptidase family M23; Region: Peptidase_M23; pfam01551 573065008638 Protein of unknown function DUF72; Region: DUF72; pfam01904 573065008639 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 573065008640 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 573065008641 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065008642 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 573065008643 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 573065008644 catalytic residues [active] 573065008645 dimer interface [polypeptide binding]; other site 573065008646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065008647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065008648 non-specific DNA binding site [nucleotide binding]; other site 573065008649 salt bridge; other site 573065008650 sequence-specific DNA binding site [nucleotide binding]; other site 573065008651 Pirin-related protein [General function prediction only]; Region: COG1741 573065008652 Pirin; Region: Pirin; pfam02678 573065008653 Predicted membrane protein [Function unknown]; Region: COG3650 573065008654 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 573065008655 active site 573065008656 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 573065008657 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 573065008658 active site 573065008659 (T/H)XGH motif; other site 573065008660 DNA gyrase, A subunit; Region: gyrA; TIGR01063 573065008661 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573065008662 CAP-like domain; other site 573065008663 active site 573065008664 primary dimer interface [polypeptide binding]; other site 573065008665 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573065008666 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573065008667 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573065008668 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573065008669 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573065008670 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573065008671 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573065008672 dimer interface [polypeptide binding]; other site 573065008673 ssDNA binding site [nucleotide binding]; other site 573065008674 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573065008675 flagellin; Provisional; Region: PRK12802 573065008676 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573065008677 FlaG protein; Region: FlaG; cl00591 573065008678 flagellin; Reviewed; Region: PRK12687 573065008679 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573065008680 flagellin; Reviewed; Region: PRK12687 573065008681 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573065008682 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794 573065008683 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794 573065008684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065008685 binding surface 573065008686 TPR repeat; Region: TPR_11; pfam13414 573065008687 TPR motif; other site 573065008688 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573065008689 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 573065008690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065008691 binding surface 573065008692 TPR motif; other site 573065008693 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573065008694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065008695 binding surface 573065008696 TPR motif; other site 573065008697 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573065008698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065008699 binding surface 573065008700 TPR motif; other site 573065008701 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573065008702 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573065008703 Ligand Binding Site [chemical binding]; other site 573065008704 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 573065008705 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 573065008706 Uncharacterized conserved protein [Function unknown]; Region: COG3743 573065008707 pyruvate phosphate dikinase; Provisional; Region: PRK09279 573065008708 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573065008709 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573065008710 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573065008711 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573065008712 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 573065008713 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 573065008714 dimer interface [polypeptide binding]; other site 573065008715 motif 1; other site 573065008716 active site 573065008717 motif 2; other site 573065008718 motif 3; other site 573065008719 muropeptide transporter; Reviewed; Region: ampG; PRK11902 573065008720 muropeptide transporter; Validated; Region: ampG; cl17669 573065008721 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 573065008722 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 573065008723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573065008724 binding surface 573065008725 TPR repeat; Region: TPR_11; pfam13414 573065008726 TPR motif; other site 573065008727 TPR repeat; Region: TPR_11; pfam13414 573065008728 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 573065008729 hydroxyglutarate oxidase; Provisional; Region: PRK11728 573065008730 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 573065008731 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 573065008732 Fe-S cluster binding site [ion binding]; other site 573065008733 active site 573065008734 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573065008735 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573065008736 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573065008737 catalytic residue [active] 573065008738 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 573065008739 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 573065008740 Probable Catalytic site; other site 573065008741 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 573065008742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065008743 S-adenosylmethionine binding site [chemical binding]; other site 573065008744 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573065008745 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 573065008746 Ligand binding site; other site 573065008747 Putative Catalytic site; other site 573065008748 DXD motif; other site 573065008749 Predicted membrane protein [Function unknown]; Region: COG2246 573065008750 GtrA-like protein; Region: GtrA; pfam04138 573065008751 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 573065008752 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 573065008753 HIGH motif; other site 573065008754 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573065008755 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 573065008756 active site 573065008757 KMSKS motif; other site 573065008758 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 573065008759 tRNA binding surface [nucleotide binding]; other site 573065008760 anticodon binding site; other site 573065008761 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 573065008762 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 573065008763 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 573065008764 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 573065008765 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065008766 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065008767 dimer interface [polypeptide binding]; other site 573065008768 putative CheW interface [polypeptide binding]; other site 573065008769 response regulator PleD; Reviewed; Region: pleD; PRK09581 573065008770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065008771 active site 573065008772 phosphorylation site [posttranslational modification] 573065008773 intermolecular recognition site; other site 573065008774 dimerization interface [polypeptide binding]; other site 573065008775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065008776 active site 573065008777 phosphorylation site [posttranslational modification] 573065008778 intermolecular recognition site; other site 573065008779 dimerization interface [polypeptide binding]; other site 573065008780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573065008781 metal binding site [ion binding]; metal-binding site 573065008782 active site 573065008783 I-site; other site 573065008784 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573065008785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065008786 active site 573065008787 phosphorylation site [posttranslational modification] 573065008788 intermolecular recognition site; other site 573065008789 dimerization interface [polypeptide binding]; other site 573065008790 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 573065008791 homotrimer interaction site [polypeptide binding]; other site 573065008792 putative active site [active] 573065008793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 573065008794 Protein of unknown function, DUF482; Region: DUF482; pfam04339 573065008795 ATP12 chaperone protein; Region: ATP12; cl02228 573065008796 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 573065008797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573065008798 motif II; other site 573065008799 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573065008800 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573065008801 active site 573065008802 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 573065008803 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 573065008804 HIT family signature motif; other site 573065008805 catalytic residue [active] 573065008806 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573065008807 catalytic core [active] 573065008808 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573065008809 PAS fold; Region: PAS_4; pfam08448 573065008810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065008811 putative active site [active] 573065008812 heme pocket [chemical binding]; other site 573065008813 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573065008814 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573065008815 metal binding site [ion binding]; metal-binding site 573065008816 active site 573065008817 I-site; other site 573065008818 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573065008819 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573065008820 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 573065008821 active site 573065008822 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 573065008823 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 573065008824 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 573065008825 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 573065008826 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 573065008827 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573065008828 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573065008829 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573065008830 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573065008831 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573065008832 active site 573065008833 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573065008834 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 573065008835 putative active site [active] 573065008836 putative metal binding site [ion binding]; other site 573065008837 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 573065008838 O-Antigen ligase; Region: Wzy_C; pfam04932 573065008839 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 573065008840 Chain length determinant protein; Region: Wzz; cl15801 573065008841 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 573065008842 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 573065008843 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 573065008844 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 573065008845 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 573065008846 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 573065008847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065008848 Walker A/P-loop; other site 573065008849 ATP binding site [chemical binding]; other site 573065008850 Q-loop/lid; other site 573065008851 ABC transporter signature motif; other site 573065008852 Walker B; other site 573065008853 D-loop; other site 573065008854 H-loop/switch region; other site 573065008855 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 573065008856 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 573065008857 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 573065008858 GatB domain; Region: GatB_Yqey; smart00845 573065008859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573065008860 Histidine kinase; Region: HisKA_3; pfam07730 573065008861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065008862 ATP binding site [chemical binding]; other site 573065008863 Mg2+ binding site [ion binding]; other site 573065008864 G-X-G motif; other site 573065008865 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573065008866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065008867 active site 573065008868 phosphorylation site [posttranslational modification] 573065008869 intermolecular recognition site; other site 573065008870 dimerization interface [polypeptide binding]; other site 573065008871 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573065008872 DNA binding residues [nucleotide binding] 573065008873 dimerization interface [polypeptide binding]; other site 573065008874 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 573065008875 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 573065008876 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065008877 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065008878 N-terminal plug; other site 573065008879 ligand-binding site [chemical binding]; other site 573065008880 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573065008881 homotrimer interaction site [polypeptide binding]; other site 573065008882 putative active site [active] 573065008883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065008884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065008885 Predicted membrane protein [Function unknown]; Region: COG1297 573065008886 putative oligopeptide transporter, OPT family; Region: TIGR00733 573065008887 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065008888 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065008889 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 573065008890 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 573065008891 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 573065008892 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 573065008893 Predicted permeases [General function prediction only]; Region: COG0679 573065008894 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 573065008895 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 573065008896 putative NAD(P) binding site [chemical binding]; other site 573065008897 putative substrate binding site [chemical binding]; other site 573065008898 catalytic Zn binding site [ion binding]; other site 573065008899 structural Zn binding site [ion binding]; other site 573065008900 dimer interface [polypeptide binding]; other site 573065008901 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 573065008902 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573065008903 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573065008904 dihydroorotase; Validated; Region: PRK09059 573065008905 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573065008906 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 573065008907 active site 573065008908 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 573065008909 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 573065008910 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 573065008911 active site 573065008912 interdomain interaction site; other site 573065008913 putative metal-binding site [ion binding]; other site 573065008914 nucleotide binding site [chemical binding]; other site 573065008915 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 573065008916 domain I; other site 573065008917 DNA binding groove [nucleotide binding] 573065008918 phosphate binding site [ion binding]; other site 573065008919 domain II; other site 573065008920 domain III; other site 573065008921 nucleotide binding site [chemical binding]; other site 573065008922 catalytic site [active] 573065008923 domain IV; other site 573065008924 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 573065008925 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 573065008926 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 573065008927 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 573065008928 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 573065008929 Predicted flavoprotein [General function prediction only]; Region: COG0431 573065008930 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573065008931 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 573065008932 Entericidin EcnA/B family; Region: Entericidin; pfam08085 573065008933 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 573065008934 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573065008935 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 573065008936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065008937 NADH(P)-binding; Region: NAD_binding_10; pfam13460 573065008938 NAD(P) binding site [chemical binding]; other site 573065008939 active site 573065008940 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 573065008941 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065008942 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065008943 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065008944 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573065008945 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002 573065008946 active site 573065008947 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 573065008948 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 573065008949 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 573065008950 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 573065008951 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 573065008952 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573065008953 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573065008954 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065008955 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065008956 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065008957 Transcriptional regulators [Transcription]; Region: GntR; COG1802 573065008958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065008959 DNA-binding site [nucleotide binding]; DNA binding site 573065008960 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573065008961 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 573065008962 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573065008963 Carboxylesterase family; Region: COesterase; pfam00135 573065008964 substrate binding pocket [chemical binding]; other site 573065008965 catalytic triad [active] 573065008966 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 573065008967 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 573065008968 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 573065008969 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573065008970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065008971 active site 573065008972 phosphorylation site [posttranslational modification] 573065008973 intermolecular recognition site; other site 573065008974 dimerization interface [polypeptide binding]; other site 573065008975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065008976 Walker A motif; other site 573065008977 ATP binding site [chemical binding]; other site 573065008978 Walker B motif; other site 573065008979 arginine finger; other site 573065008980 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573065008981 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573065008982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065008983 ATP binding site [chemical binding]; other site 573065008984 Mg2+ binding site [ion binding]; other site 573065008985 G-X-G motif; other site 573065008986 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573065008987 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573065008988 Walker A/P-loop; other site 573065008989 ATP binding site [chemical binding]; other site 573065008990 Q-loop/lid; other site 573065008991 ABC transporter signature motif; other site 573065008992 Walker B; other site 573065008993 D-loop; other site 573065008994 H-loop/switch region; other site 573065008995 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573065008996 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573065008997 FtsX-like permease family; Region: FtsX; pfam02687 573065008998 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 573065008999 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573065009000 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573065009001 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065009002 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065009003 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065009004 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573065009005 MULE transposase domain; Region: MULE; pfam10551 573065009006 Protein of unknown function (DUF805); Region: DUF805; pfam05656 573065009007 CVNH domain; Region: CVNH; pfam08881 573065009008 CVNH domain; Region: CVNH; pfam08881 573065009009 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 573065009010 EF-hand domain pair; Region: EF_hand_5; pfam13499 573065009011 Ca2+ binding site [ion binding]; other site 573065009012 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 573065009013 Prephenate dehydrogenase; Region: PDH; pfam02153 573065009014 arogenate dehydrogenase; Region: PLN02256 573065009015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573065009016 Transposase; Region: HTH_Tnp_1; pfam01527 573065009017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573065009018 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 573065009019 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 573065009020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 573065009021 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 573065009022 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 573065009023 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 573065009024 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 573065009025 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 573065009026 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 573065009027 TrkA-N domain; Region: TrkA_N; pfam02254 573065009028 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 573065009029 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 573065009030 active site 573065009031 Zn binding site [ion binding]; other site 573065009032 WHG domain; Region: WHG; pfam13305 573065009033 histidyl-tRNA synthetase; Region: hisS; TIGR00442 573065009034 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 573065009035 dimer interface [polypeptide binding]; other site 573065009036 motif 1; other site 573065009037 motif 2; other site 573065009038 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573065009039 active site 573065009040 motif 3; other site 573065009041 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 573065009042 anticodon binding site; other site 573065009043 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 573065009044 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 573065009045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065009046 S-adenosylmethionine binding site [chemical binding]; other site 573065009047 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 573065009048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065009049 S-adenosylmethionine binding site [chemical binding]; other site 573065009050 aspartate kinase; Reviewed; Region: PRK06635 573065009051 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 573065009052 putative nucleotide binding site [chemical binding]; other site 573065009053 putative catalytic residues [active] 573065009054 putative Mg ion binding site [ion binding]; other site 573065009055 putative aspartate binding site [chemical binding]; other site 573065009056 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 573065009057 putative allosteric regulatory site; other site 573065009058 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 573065009059 putative allosteric regulatory residue; other site 573065009060 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 573065009061 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573065009062 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 573065009063 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573065009064 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573065009065 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 573065009066 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 573065009067 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 573065009068 DsbD alpha interface [polypeptide binding]; other site 573065009069 catalytic residues [active] 573065009070 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 573065009071 nitrilase; Region: PLN02798 573065009072 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 573065009073 putative active site [active] 573065009074 catalytic triad [active] 573065009075 dimer interface [polypeptide binding]; other site 573065009076 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 573065009077 GSH binding site [chemical binding]; other site 573065009078 catalytic residues [active] 573065009079 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 573065009080 Methyltransferase domain; Region: Methyltransf_11; pfam08241 573065009081 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 573065009082 active site 573065009083 8-oxo-dGMP binding site [chemical binding]; other site 573065009084 nudix motif; other site 573065009085 metal binding site [ion binding]; metal-binding site 573065009086 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 573065009087 heterotetramer interface [polypeptide binding]; other site 573065009088 active site pocket [active] 573065009089 cleavage site 573065009090 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 573065009091 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573065009092 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 573065009093 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 573065009094 SEC-C motif; Region: SEC-C; pfam02810 573065009095 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 573065009096 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573065009097 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573065009098 putative acyl-acceptor binding pocket; other site 573065009099 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 573065009100 putative active site [active] 573065009101 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 573065009102 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 573065009103 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573065009104 Walker A/P-loop; other site 573065009105 ATP binding site [chemical binding]; other site 573065009106 Q-loop/lid; other site 573065009107 ABC transporter signature motif; other site 573065009108 Walker B; other site 573065009109 D-loop; other site 573065009110 H-loop/switch region; other site 573065009111 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 573065009112 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 573065009113 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 573065009114 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573065009115 active site 573065009116 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 573065009117 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 573065009118 Protein export membrane protein; Region: SecD_SecF; cl14618 573065009119 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 573065009120 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 573065009121 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 573065009122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065009123 PAS domain; Region: PAS_9; pfam13426 573065009124 putative active site [active] 573065009125 heme pocket [chemical binding]; other site 573065009126 PAS fold; Region: PAS_7; pfam12860 573065009127 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573065009128 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573065009129 metal binding site [ion binding]; metal-binding site 573065009130 active site 573065009131 I-site; other site 573065009132 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573065009133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065009134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065009135 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573065009136 Predicted membrane protein/domain [Function unknown]; Region: COG1714 573065009137 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 573065009138 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 573065009139 Protein of unknown function DUF58; Region: DUF58; pfam01882 573065009140 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 573065009141 metal ion-dependent adhesion site (MIDAS); other site 573065009142 MoxR-like ATPases [General function prediction only]; Region: COG0714 573065009143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065009144 Walker A motif; other site 573065009145 ATP binding site [chemical binding]; other site 573065009146 Walker B motif; other site 573065009147 arginine finger; other site 573065009148 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009149 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065009150 CHASE2 domain; Region: CHASE2; pfam05226 573065009151 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573065009152 Cytochrome c; Region: Cytochrom_C; cl11414 573065009153 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 573065009154 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 573065009155 XdhC Rossmann domain; Region: XdhC_C; pfam13478 573065009156 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573065009157 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 573065009158 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573065009159 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573065009160 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573065009161 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 573065009162 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573065009163 catalytic loop [active] 573065009164 iron binding site [ion binding]; other site 573065009165 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573065009166 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 573065009167 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 573065009168 Ligand binding site; other site 573065009169 metal-binding site 573065009170 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 573065009171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065009172 putative substrate translocation pore; other site 573065009173 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 573065009174 maleylacetoacetate isomerase; Region: maiA; TIGR01262 573065009175 C-terminal domain interface [polypeptide binding]; other site 573065009176 GSH binding site (G-site) [chemical binding]; other site 573065009177 putative dimer interface [polypeptide binding]; other site 573065009178 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 573065009179 dimer interface [polypeptide binding]; other site 573065009180 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 573065009181 N-terminal domain interface [polypeptide binding]; other site 573065009182 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573065009183 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 573065009184 ligand binding site [chemical binding]; other site 573065009185 flexible hinge region; other site 573065009186 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 573065009187 putative switch regulator; other site 573065009188 non-specific DNA interactions [nucleotide binding]; other site 573065009189 DNA binding site [nucleotide binding] 573065009190 sequence specific DNA binding site [nucleotide binding]; other site 573065009191 putative cAMP binding site [chemical binding]; other site 573065009192 Response regulator receiver domain; Region: Response_reg; pfam00072 573065009193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065009194 active site 573065009195 phosphorylation site [posttranslational modification] 573065009196 intermolecular recognition site; other site 573065009197 dimerization interface [polypeptide binding]; other site 573065009198 Pectic acid lyase; Region: Pec_lyase; pfam09492 573065009199 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 573065009200 active site 573065009201 zinc binding site [ion binding]; other site 573065009202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065009203 D-galactonate transporter; Region: 2A0114; TIGR00893 573065009204 putative substrate translocation pore; other site 573065009205 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 573065009206 active site 573065009207 catalytic residues [active] 573065009208 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 573065009209 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 573065009210 dimer interface [polypeptide binding]; other site 573065009211 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 573065009212 active site 573065009213 Fe binding site [ion binding]; other site 573065009214 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 573065009215 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 573065009216 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 573065009217 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 573065009218 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 573065009219 iron-sulfur cluster [ion binding]; other site 573065009220 [2Fe-2S] cluster binding site [ion binding]; other site 573065009221 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 573065009222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573065009223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573065009224 homodimer interface [polypeptide binding]; other site 573065009225 catalytic residue [active] 573065009226 Domain of unknown function (DUF718); Region: DUF718; cl01281 573065009227 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 573065009228 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573065009229 Zn2+ binding site [ion binding]; other site 573065009230 Mg2+ binding site [ion binding]; other site 573065009231 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 573065009232 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573065009233 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 573065009234 putative DNA binding site [nucleotide binding]; other site 573065009235 putative Zn2+ binding site [ion binding]; other site 573065009236 AsnC family; Region: AsnC_trans_reg; pfam01037 573065009237 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 573065009238 proposed catalytic triad [active] 573065009239 active site nucleophile [active] 573065009240 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 573065009241 catalytic nucleophile [active] 573065009242 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 573065009243 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065009244 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009245 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 573065009246 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 573065009247 active site 573065009248 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065009249 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065009250 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065009251 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065009252 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065009253 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009254 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009255 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573065009256 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 573065009257 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 573065009258 active site 573065009259 catalytic site [active] 573065009260 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 573065009261 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573065009262 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 573065009263 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573065009264 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 573065009265 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 573065009266 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 573065009267 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 573065009268 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573065009269 alpha-galactosidase; Region: PLN02808; cl17638 573065009270 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 573065009271 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 573065009272 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573065009273 HAMP domain; Region: HAMP; pfam00672 573065009274 dimerization interface [polypeptide binding]; other site 573065009275 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065009276 dimer interface [polypeptide binding]; other site 573065009277 putative CheW interface [polypeptide binding]; other site 573065009278 Response regulator receiver domain; Region: Response_reg; pfam00072 573065009279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065009280 active site 573065009281 phosphorylation site [posttranslational modification] 573065009282 intermolecular recognition site; other site 573065009283 dimerization interface [polypeptide binding]; other site 573065009284 Response regulator receiver domain; Region: Response_reg; pfam00072 573065009285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065009286 active site 573065009287 phosphorylation site [posttranslational modification] 573065009288 intermolecular recognition site; other site 573065009289 dimerization interface [polypeptide binding]; other site 573065009290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065009291 dimer interface [polypeptide binding]; other site 573065009292 phosphorylation site [posttranslational modification] 573065009293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065009294 ATP binding site [chemical binding]; other site 573065009295 Mg2+ binding site [ion binding]; other site 573065009296 G-X-G motif; other site 573065009297 Response regulator receiver domain; Region: Response_reg; pfam00072 573065009298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065009299 active site 573065009300 phosphorylation site [posttranslational modification] 573065009301 intermolecular recognition site; other site 573065009302 dimerization interface [polypeptide binding]; other site 573065009303 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065009304 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 573065009305 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 573065009306 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 573065009307 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 573065009308 oligomeric interface; other site 573065009309 putative active site [active] 573065009310 homodimer interface [polypeptide binding]; other site 573065009311 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 573065009312 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 573065009313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065009314 ABC-ATPase subunit interface; other site 573065009315 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 573065009316 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 573065009317 Walker A/P-loop; other site 573065009318 ATP binding site [chemical binding]; other site 573065009319 Q-loop/lid; other site 573065009320 ABC transporter signature motif; other site 573065009321 Walker B; other site 573065009322 D-loop; other site 573065009323 H-loop/switch region; other site 573065009324 NIL domain; Region: NIL; pfam09383 573065009325 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009326 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009327 Predicted membrane protein [Function unknown]; Region: COG2261 573065009328 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573065009329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065009330 DNA-binding site [nucleotide binding]; DNA binding site 573065009331 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573065009332 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 573065009333 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 573065009334 putative active site pocket [active] 573065009335 putative metal binding site [ion binding]; other site 573065009336 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 573065009337 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 573065009338 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 573065009339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065009340 PAS domain; Region: PAS_9; pfam13426 573065009341 putative active site [active] 573065009342 heme pocket [chemical binding]; other site 573065009343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 573065009344 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065009345 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065009346 dimer interface [polypeptide binding]; other site 573065009347 putative CheW interface [polypeptide binding]; other site 573065009348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065009349 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573065009350 NAD(P) binding site [chemical binding]; other site 573065009351 active site 573065009352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065009353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065009354 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 573065009355 dimerization interface [polypeptide binding]; other site 573065009356 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573065009357 DNA-binding site [nucleotide binding]; DNA binding site 573065009358 RNA-binding motif; other site 573065009359 MFS/sugar transport protein; Region: MFS_2; pfam13347 573065009360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065009361 putative substrate translocation pore; other site 573065009362 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065009363 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065009364 DNA binding site [nucleotide binding] 573065009365 domain linker motif; other site 573065009366 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 573065009367 putative dimerization interface [polypeptide binding]; other site 573065009368 putative ligand binding site [chemical binding]; other site 573065009369 Trehalose utilisation; Region: ThuA; pfam06283 573065009370 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065009371 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 573065009372 N-terminal plug; other site 573065009373 ligand-binding site [chemical binding]; other site 573065009374 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 573065009375 active site 573065009376 catalytic residues [active] 573065009377 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 573065009378 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 573065009379 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 573065009380 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 573065009381 active site 573065009382 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 573065009383 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 573065009384 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 573065009385 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 573065009386 active site 573065009387 Zn binding site [ion binding]; other site 573065009388 Replication initiator protein A; Region: RPA; pfam10134 573065009389 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573065009390 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573065009391 P-loop; other site 573065009392 Magnesium ion binding site [ion binding]; other site 573065009393 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 573065009394 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 573065009395 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573065009396 dimer interface [polypeptide binding]; other site 573065009397 active site 573065009398 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 573065009399 dimer interface [polypeptide binding]; other site 573065009400 active site 573065009401 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009402 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009403 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 573065009404 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065009405 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065009406 DNA binding site [nucleotide binding] 573065009407 domain linker motif; other site 573065009408 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573065009409 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 573065009410 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 573065009411 NADP binding site [chemical binding]; other site 573065009412 homodimer interface [polypeptide binding]; other site 573065009413 active site 573065009414 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 573065009415 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573065009416 phosphate binding site [ion binding]; other site 573065009417 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 573065009418 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 573065009419 Walker A/P-loop; other site 573065009420 ATP binding site [chemical binding]; other site 573065009421 Q-loop/lid; other site 573065009422 ABC transporter signature motif; other site 573065009423 Walker B; other site 573065009424 D-loop; other site 573065009425 H-loop/switch region; other site 573065009426 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 573065009427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065009428 dimer interface [polypeptide binding]; other site 573065009429 conserved gate region; other site 573065009430 putative PBP binding loops; other site 573065009431 ABC-ATPase subunit interface; other site 573065009432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065009433 dimer interface [polypeptide binding]; other site 573065009434 conserved gate region; other site 573065009435 putative PBP binding loops; other site 573065009436 ABC-ATPase subunit interface; other site 573065009437 PBP superfamily domain; Region: PBP_like_2; cl17296 573065009438 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065009439 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065009440 dimer interface [polypeptide binding]; other site 573065009441 putative CheW interface [polypeptide binding]; other site 573065009442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065009443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065009444 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573065009445 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573065009446 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065009447 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 573065009448 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 573065009449 Cupin-like domain; Region: Cupin_8; pfam13621 573065009450 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065009451 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065009452 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065009453 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065009454 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009455 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009456 Cupin-like domain; Region: Cupin_8; pfam13621 573065009457 Predicted transcriptional regulator [Transcription]; Region: COG4957 573065009458 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 573065009459 putative active site [active] 573065009460 catalytic site [active] 573065009461 putative metal binding site [ion binding]; other site 573065009462 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065009463 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009464 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009465 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573065009466 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573065009467 metal binding site [ion binding]; metal-binding site 573065009468 active site 573065009469 I-site; other site 573065009470 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573065009471 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 573065009472 Fasciclin domain; Region: Fasciclin; pfam02469 573065009473 Protein of unknown function, DUF393; Region: DUF393; pfam04134 573065009474 PHP domain; Region: PHP; pfam02811 573065009475 Transcriptional regulators [Transcription]; Region: GntR; COG1802 573065009476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065009477 DNA-binding site [nucleotide binding]; DNA binding site 573065009478 FCD domain; Region: FCD; pfam07729 573065009479 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 573065009480 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 573065009481 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573065009482 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 573065009483 inhibitor site; inhibition site 573065009484 active site 573065009485 dimer interface [polypeptide binding]; other site 573065009486 catalytic residue [active] 573065009487 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 573065009488 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 573065009489 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 573065009490 active site 573065009491 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 573065009492 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065009493 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065009494 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065009495 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 573065009496 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065009497 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065009498 DNA binding site [nucleotide binding] 573065009499 domain linker motif; other site 573065009500 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573065009501 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573065009502 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573065009503 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 573065009504 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573065009505 Carboxylesterase family; Region: COesterase; pfam00135 573065009506 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573065009507 substrate binding pocket [chemical binding]; other site 573065009508 catalytic triad [active] 573065009509 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573065009510 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573065009511 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 573065009512 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573065009513 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573065009514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065009515 active site 573065009516 phosphorylation site [posttranslational modification] 573065009517 intermolecular recognition site; other site 573065009518 dimerization interface [polypeptide binding]; other site 573065009519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573065009520 Walker A motif; other site 573065009521 ATP binding site [chemical binding]; other site 573065009522 Walker B motif; other site 573065009523 arginine finger; other site 573065009524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065009525 dimer interface [polypeptide binding]; other site 573065009526 phosphorylation site [posttranslational modification] 573065009527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065009528 ATP binding site [chemical binding]; other site 573065009529 Mg2+ binding site [ion binding]; other site 573065009530 G-X-G motif; other site 573065009531 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 573065009532 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 573065009533 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 573065009534 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573065009535 PAS domain; Region: PAS_8; pfam13188 573065009536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065009537 ATP binding site [chemical binding]; other site 573065009538 G-X-G motif; other site 573065009539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065009540 Response regulator receiver domain; Region: Response_reg; pfam00072 573065009541 active site 573065009542 phosphorylation site [posttranslational modification] 573065009543 intermolecular recognition site; other site 573065009544 dimerization interface [polypeptide binding]; other site 573065009545 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573065009546 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573065009547 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573065009548 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065009549 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573065009550 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573065009551 Walker A/P-loop; other site 573065009552 ATP binding site [chemical binding]; other site 573065009553 Q-loop/lid; other site 573065009554 ABC transporter signature motif; other site 573065009555 Walker B; other site 573065009556 D-loop; other site 573065009557 H-loop/switch region; other site 573065009558 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573065009559 FtsX-like permease family; Region: FtsX; pfam02687 573065009560 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573065009561 FtsX-like permease family; Region: FtsX; pfam02687 573065009562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065009563 D-galactonate transporter; Region: 2A0114; TIGR00893 573065009564 putative substrate translocation pore; other site 573065009565 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573065009566 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573065009567 Bacterial transcriptional regulator; Region: IclR; pfam01614 573065009568 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 573065009569 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573065009570 putative NAD(P) binding site [chemical binding]; other site 573065009571 catalytic Zn binding site [ion binding]; other site 573065009572 structural Zn binding site [ion binding]; other site 573065009573 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 573065009574 putative pectinesterase; Region: PLN02432; cl01911 573065009575 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573065009576 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 573065009577 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065009578 Secretin and TonB N terminus short domain; Region: STN; smart00965 573065009579 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065009580 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009581 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009582 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 573065009583 FecR protein; Region: FecR; pfam04773 573065009584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065009585 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573065009586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065009587 DNA binding residues [nucleotide binding] 573065009588 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 573065009589 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 573065009590 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 573065009591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573065009592 NAD(P) binding site [chemical binding]; other site 573065009593 active site 573065009594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065009595 putative substrate translocation pore; other site 573065009596 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065009597 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065009598 N-terminal plug; other site 573065009599 ligand-binding site [chemical binding]; other site 573065009600 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 573065009601 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 573065009602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065009603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065009604 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573065009605 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 573065009606 substrate binding pocket [chemical binding]; other site 573065009607 Autoinducer binding domain; Region: Autoind_bind; pfam03472 573065009608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573065009609 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573065009610 DNA binding residues [nucleotide binding] 573065009611 dimerization interface [polypeptide binding]; other site 573065009612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065009613 PAS domain; Region: PAS_9; pfam13426 573065009614 putative active site [active] 573065009615 heme pocket [chemical binding]; other site 573065009616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065009617 PAS domain; Region: PAS_9; pfam13426 573065009618 putative active site [active] 573065009619 heme pocket [chemical binding]; other site 573065009620 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065009621 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065009622 dimer interface [polypeptide binding]; other site 573065009623 putative CheW interface [polypeptide binding]; other site 573065009624 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573065009625 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573065009626 metal-binding site [ion binding] 573065009627 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573065009628 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573065009629 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 573065009630 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 573065009631 FixH; Region: FixH; pfam05751 573065009632 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 573065009633 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573065009634 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573065009635 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 573065009636 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 573065009637 Cytochrome c; Region: Cytochrom_C; pfam00034 573065009638 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 573065009639 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 573065009640 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 573065009641 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 573065009642 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 573065009643 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 573065009644 Low-spin heme binding site [chemical binding]; other site 573065009645 Putative water exit pathway; other site 573065009646 Binuclear center (active site) [active] 573065009647 Putative proton exit pathway; other site 573065009648 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 573065009649 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573065009650 ligand binding site [chemical binding]; other site 573065009651 flexible hinge region; other site 573065009652 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 573065009653 Predicted metalloprotease [General function prediction only]; Region: COG2321 573065009654 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 573065009655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065009656 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573065009657 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065009658 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573065009659 Protein export membrane protein; Region: SecD_SecF; cl14618 573065009660 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573065009661 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 573065009662 active site 573065009663 dimer interface [polypeptide binding]; other site 573065009664 metal binding site [ion binding]; metal-binding site 573065009665 shikimate kinase; Provisional; Region: PRK13946 573065009666 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 573065009667 ADP binding site [chemical binding]; other site 573065009668 magnesium binding site [ion binding]; other site 573065009669 putative shikimate binding site; other site 573065009670 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573065009671 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 573065009672 active site 573065009673 DNA binding site [nucleotide binding] 573065009674 Int/Topo IB signature motif; other site 573065009675 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 573065009676 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 573065009677 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 573065009678 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 573065009679 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 573065009680 Zn binding site [ion binding]; other site 573065009681 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573065009682 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573065009683 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 573065009684 nucleoside/Zn binding site; other site 573065009685 dimer interface [polypeptide binding]; other site 573065009686 catalytic motif [active] 573065009687 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 573065009688 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573065009689 RNA binding surface [nucleotide binding]; other site 573065009690 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 573065009691 probable active site [active] 573065009692 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 573065009693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573065009694 S-adenosylmethionine binding site [chemical binding]; other site 573065009695 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 573065009696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065009697 ATP binding site [chemical binding]; other site 573065009698 Mg2+ binding site [ion binding]; other site 573065009699 G-X-G motif; other site 573065009700 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 573065009701 ATP binding site [chemical binding]; other site 573065009702 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 573065009703 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 573065009704 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 573065009705 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 573065009706 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573065009707 active site 573065009708 HIGH motif; other site 573065009709 nucleotide binding site [chemical binding]; other site 573065009710 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 573065009711 active site 573065009712 KMSKS motif; other site 573065009713 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 573065009714 tRNA binding surface [nucleotide binding]; other site 573065009715 anticodon binding site; other site 573065009716 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 573065009717 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 573065009718 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 573065009719 putative uracil binding site [chemical binding]; other site 573065009720 putative active site [active] 573065009721 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 573065009722 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 573065009723 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573065009724 RNA binding surface [nucleotide binding]; other site 573065009725 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 573065009726 active site 573065009727 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 573065009728 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065009729 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009730 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 573065009731 FecR protein; Region: FecR; pfam04773 573065009732 K+-transporting ATPase, c chain; Region: KdpC; cl00944 573065009733 RNA polymerase sigma factor; Provisional; Region: PRK12528 573065009734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065009735 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065009736 DNA binding residues [nucleotide binding] 573065009737 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 573065009738 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573065009739 putative ADP-binding pocket [chemical binding]; other site 573065009740 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573065009741 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 573065009742 active site 573065009743 SUMO-1 interface [polypeptide binding]; other site 573065009744 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 573065009745 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 573065009746 Tetramer interface [polypeptide binding]; other site 573065009747 active site 573065009748 FMN-binding site [chemical binding]; other site 573065009749 chaperone protein DnaJ; Provisional; Region: PRK14299 573065009750 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 573065009751 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 573065009752 substrate binding site [polypeptide binding]; other site 573065009753 dimer interface [polypeptide binding]; other site 573065009754 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 573065009755 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 573065009756 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 573065009757 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 573065009758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573065009759 motif II; other site 573065009760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 573065009761 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573065009762 Predicted kinase [General function prediction only]; Region: COG0645 573065009763 AAA domain; Region: AAA_17; pfam13207 573065009764 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 573065009765 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 573065009766 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065009767 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009768 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 573065009769 ribonuclease R; Region: RNase_R; TIGR02063 573065009770 RNB domain; Region: RNB; pfam00773 573065009771 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 573065009772 RNA binding site [nucleotide binding]; other site 573065009773 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 573065009774 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 573065009775 active site 573065009776 Riboflavin kinase; Region: Flavokinase; pfam01687 573065009777 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 573065009778 dimer interaction site [polypeptide binding]; other site 573065009779 substrate-binding tunnel; other site 573065009780 active site 573065009781 catalytic site [active] 573065009782 substrate binding site [chemical binding]; other site 573065009783 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 573065009784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065009785 active site 573065009786 phosphorylation site [posttranslational modification] 573065009787 intermolecular recognition site; other site 573065009788 dimerization interface [polypeptide binding]; other site 573065009789 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 573065009790 Response regulator receiver domain; Region: Response_reg; pfam00072 573065009791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065009792 active site 573065009793 phosphorylation site [posttranslational modification] 573065009794 intermolecular recognition site; other site 573065009795 dimerization interface [polypeptide binding]; other site 573065009796 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 573065009797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573065009798 active site 573065009799 motif I; other site 573065009800 motif II; other site 573065009801 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 573065009802 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573065009803 Response regulator receiver domain; Region: Response_reg; pfam00072 573065009804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065009805 active site 573065009806 phosphorylation site [posttranslational modification] 573065009807 intermolecular recognition site; other site 573065009808 dimerization interface [polypeptide binding]; other site 573065009809 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573065009810 Peptidase family M23; Region: Peptidase_M23; pfam01551 573065009811 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; cl11535 573065009812 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 573065009813 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573065009814 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 573065009815 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 573065009816 generic binding surface II; other site 573065009817 generic binding surface I; other site 573065009818 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573065009819 GAF domain; Region: GAF; pfam01590 573065009820 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065009821 PAS fold; Region: PAS_3; pfam08447 573065009822 putative active site [active] 573065009823 heme pocket [chemical binding]; other site 573065009824 alpha-galactosidase; Region: PLN02808; cl17638 573065009825 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 573065009826 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 573065009827 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 573065009828 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 573065009829 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 573065009830 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065009831 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009832 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 573065009833 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 573065009834 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 573065009835 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 573065009836 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 573065009837 putative acyl-acceptor binding pocket; other site 573065009838 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573065009839 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573065009840 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 573065009841 Walker A/P-loop; other site 573065009842 ATP binding site [chemical binding]; other site 573065009843 Q-loop/lid; other site 573065009844 ABC transporter signature motif; other site 573065009845 Walker B; other site 573065009846 D-loop; other site 573065009847 H-loop/switch region; other site 573065009848 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 573065009849 Putative phosphatase (DUF442); Region: DUF442; cl17385 573065009850 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 573065009851 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 573065009852 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 573065009853 active site 573065009854 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 573065009855 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 573065009856 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573065009857 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573065009858 metal binding site [ion binding]; metal-binding site 573065009859 active site 573065009860 I-site; other site 573065009861 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573065009862 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 573065009863 active site 573065009864 catalytic triad [active] 573065009865 oxyanion hole [active] 573065009866 Helix-turn-helix domain; Region: HTH_18; pfam12833 573065009867 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 573065009868 dimer interface [polypeptide binding]; other site 573065009869 Alkaline phosphatase homologues; Region: alkPPc; smart00098 573065009870 active site 573065009871 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 573065009872 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573065009873 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 573065009874 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 573065009875 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 573065009876 hydrophilic channel; other site 573065009877 active site 573065009878 catalytic residues [active] 573065009879 active site lid [active] 573065009880 dimerization interface [polypeptide binding]; other site 573065009881 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 573065009882 ABC1 family; Region: ABC1; pfam03109 573065009883 HAMP domain; Region: HAMP; pfam00672 573065009884 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573065009885 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065009886 dimer interface [polypeptide binding]; other site 573065009887 putative CheW interface [polypeptide binding]; other site 573065009888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065009889 putative substrate translocation pore; other site 573065009890 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573065009891 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065009892 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573065009893 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065009894 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009895 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009896 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573065009897 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573065009898 DNA binding site [nucleotide binding] 573065009899 domain linker motif; other site 573065009900 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 573065009901 putative dimerization interface [polypeptide binding]; other site 573065009902 putative ligand binding site [chemical binding]; other site 573065009903 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 573065009904 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 573065009905 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 573065009906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 573065009907 Histidine kinase; Region: HisKA_3; pfam07730 573065009908 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573065009909 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573065009910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065009911 active site 573065009912 phosphorylation site [posttranslational modification] 573065009913 intermolecular recognition site; other site 573065009914 dimerization interface [polypeptide binding]; other site 573065009915 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573065009916 DNA binding residues [nucleotide binding] 573065009917 dimerization interface [polypeptide binding]; other site 573065009918 CHASE3 domain; Region: CHASE3; pfam05227 573065009919 HAMP domain; Region: HAMP; pfam00672 573065009920 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573065009921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573065009922 putative active site [active] 573065009923 heme pocket [chemical binding]; other site 573065009924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573065009925 dimer interface [polypeptide binding]; other site 573065009926 phosphorylation site [posttranslational modification] 573065009927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573065009928 ATP binding site [chemical binding]; other site 573065009929 Mg2+ binding site [ion binding]; other site 573065009930 G-X-G motif; other site 573065009931 Response regulator receiver domain; Region: Response_reg; pfam00072 573065009932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573065009933 active site 573065009934 phosphorylation site [posttranslational modification] 573065009935 intermolecular recognition site; other site 573065009936 dimerization interface [polypeptide binding]; other site 573065009937 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 573065009938 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 573065009939 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 573065009940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065009941 D-galactonate transporter; Region: 2A0114; TIGR00893 573065009942 putative substrate translocation pore; other site 573065009943 Alginate lyase; Region: Alginate_lyase; pfam05426 573065009944 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 573065009945 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573065009946 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065009947 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 573065009948 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009949 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065009950 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573065009951 AAA domain; Region: AAA_22; pfam13401 573065009952 AAA domain; Region: AAA_14; pfam13173 573065009953 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 573065009954 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573065009955 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573065009956 Bacterial transcriptional regulator; Region: IclR; pfam01614 573065009957 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 573065009958 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 573065009959 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 573065009960 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573065009961 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065009962 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 573065009963 active site 573065009964 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 573065009965 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 573065009966 dimerization interface [polypeptide binding]; other site 573065009967 ligand binding site [chemical binding]; other site 573065009968 NADP binding site [chemical binding]; other site 573065009969 catalytic site [active] 573065009970 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 573065009971 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 573065009972 putative NAD(P) binding site [chemical binding]; other site 573065009973 dimer interface [polypeptide binding]; other site 573065009974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065009975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065009976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573065009977 dimerization interface [polypeptide binding]; other site 573065009978 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573065009979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573065009980 dimerization interface [polypeptide binding]; other site 573065009981 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065009982 dimer interface [polypeptide binding]; other site 573065009983 putative CheW interface [polypeptide binding]; other site 573065009984 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 573065009985 DNA binding residues [nucleotide binding] 573065009986 MerR family regulatory protein; Region: MerR; pfam00376 573065009987 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573065009988 P-loop; other site 573065009989 Magnesium ion binding site [ion binding]; other site 573065009990 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573065009991 Magnesium ion binding site [ion binding]; other site 573065009992 ParB-like nuclease domain; Region: ParB; smart00470 573065009993 Replication initiator protein A; Region: RPA; pfam10134 573065009994 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 573065009995 active site 573065009996 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 573065009997 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573065009998 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 573065009999 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573065010000 dimer interface [polypeptide binding]; other site 573065010001 PYR/PP interface [polypeptide binding]; other site 573065010002 TPP binding site [chemical binding]; other site 573065010003 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573065010004 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 573065010005 TPP-binding site [chemical binding]; other site 573065010006 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573065010007 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573065010008 substrate binding site [chemical binding]; other site 573065010009 ATP binding site [chemical binding]; other site 573065010010 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 573065010011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 573065010012 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573065010013 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573065010014 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573065010015 putative active site [active] 573065010016 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573065010017 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573065010018 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573065010019 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 573065010020 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 573065010021 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573065010022 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573065010023 TM-ABC transporter signature motif; other site 573065010024 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573065010025 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573065010026 Walker A/P-loop; other site 573065010027 ATP binding site [chemical binding]; other site 573065010028 Q-loop/lid; other site 573065010029 ABC transporter signature motif; other site 573065010030 Walker B; other site 573065010031 D-loop; other site 573065010032 H-loop/switch region; other site 573065010033 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573065010034 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573065010035 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573065010036 ligand binding site [chemical binding]; other site 573065010037 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 573065010038 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 573065010039 tetrameric interface [polypeptide binding]; other site 573065010040 NAD binding site [chemical binding]; other site 573065010041 catalytic residues [active] 573065010042 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 573065010043 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 573065010044 Subunit I/III interface [polypeptide binding]; other site 573065010045 Subunit III/IV interface [polypeptide binding]; other site 573065010046 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 573065010047 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 573065010048 D-pathway; other site 573065010049 Putative ubiquinol binding site [chemical binding]; other site 573065010050 Low-spin heme (heme b) binding site [chemical binding]; other site 573065010051 Putative water exit pathway; other site 573065010052 Binuclear center (heme o3/CuB) [ion binding]; other site 573065010053 K-pathway; other site 573065010054 Putative proton exit pathway; other site 573065010055 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 573065010056 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 573065010057 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 573065010058 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 573065010059 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573065010060 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573065010061 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573065010062 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573065010063 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573065010064 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573065010065 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 573065010066 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 573065010067 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 573065010068 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065010069 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 573065010070 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010071 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 573065010072 Pectic acid lyase; Region: Pec_lyase; pfam09492 573065010073 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 573065010074 dimer interface [polypeptide binding]; other site 573065010075 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065010076 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065010077 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065010078 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 573065010079 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065010080 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010081 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010082 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_1; cd11747 573065010083 homodimer interface [polypeptide binding]; other site 573065010084 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 573065010085 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 573065010086 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 573065010087 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 573065010088 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065010089 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065010090 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065010091 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 573065010092 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 573065010093 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 573065010094 Uncharacterized conserved protein [Function unknown]; Region: COG1262 573065010095 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 573065010096 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065010097 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010098 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010099 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 573065010100 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 573065010101 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 573065010102 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 573065010103 active site 573065010104 catalytic site [active] 573065010105 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 573065010106 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 573065010107 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 573065010108 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 573065010109 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 573065010110 substrate binding site [chemical binding]; other site 573065010111 active site 573065010112 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573065010113 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573065010114 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573065010115 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 573065010116 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 573065010117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 573065010118 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 573065010119 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 573065010120 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 573065010121 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065010122 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010123 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010124 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 573065010125 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 573065010126 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573065010127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065010128 DNA-binding site [nucleotide binding]; DNA binding site 573065010129 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573065010130 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573065010131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065010132 DNA-binding site [nucleotide binding]; DNA binding site 573065010133 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573065010134 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065010135 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010136 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010137 YCII-related domain; Region: YCII; cl00999 573065010138 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 573065010139 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 573065010140 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 573065010141 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573065010142 NADP binding site [chemical binding]; other site 573065010143 putative substrate binding site [chemical binding]; other site 573065010144 active site 573065010145 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 573065010146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573065010147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065010148 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 573065010149 putative effector binding pocket; other site 573065010150 dimerization interface [polypeptide binding]; other site 573065010151 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 573065010152 Active site serine [active] 573065010153 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573065010154 Beta-lactamase; Region: Beta-lactamase; pfam00144 573065010155 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 573065010156 substrate binding site [chemical binding]; other site 573065010157 active site 573065010158 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573065010159 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573065010160 Cache domain; Region: Cache_1; pfam02743 573065010161 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573065010162 HAMP domain; Region: HAMP; pfam00672 573065010163 dimerization interface [polypeptide binding]; other site 573065010164 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573065010165 dimer interface [polypeptide binding]; other site 573065010166 putative CheW interface [polypeptide binding]; other site 573065010167 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 573065010168 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 573065010169 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 573065010170 sugar binding site [chemical binding]; other site 573065010171 allophanate hydrolase; Provisional; Region: PRK08186 573065010172 Amidase; Region: Amidase; cl11426 573065010173 urea carboxylase; Region: urea_carbox; TIGR02712 573065010174 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573065010175 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573065010176 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 573065010177 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 573065010178 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 573065010179 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573065010180 carboxyltransferase (CT) interaction site; other site 573065010181 biotinylation site [posttranslational modification]; other site 573065010182 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 573065010183 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 573065010184 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 573065010185 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 573065010186 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 573065010187 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 573065010188 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 573065010189 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 573065010190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573065010191 putative PBP binding loops; other site 573065010192 dimer interface [polypeptide binding]; other site 573065010193 ABC-ATPase subunit interface; other site 573065010194 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573065010195 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573065010196 Walker A/P-loop; other site 573065010197 ATP binding site [chemical binding]; other site 573065010198 Q-loop/lid; other site 573065010199 ABC transporter signature motif; other site 573065010200 Walker B; other site 573065010201 D-loop; other site 573065010202 H-loop/switch region; other site 573065010203 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 573065010204 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 573065010205 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 573065010206 oligomeric interface; other site 573065010207 putative active site [active] 573065010208 homodimer interface [polypeptide binding]; other site 573065010209 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 573065010210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 573065010211 non-specific DNA binding site [nucleotide binding]; other site 573065010212 salt bridge; other site 573065010213 sequence-specific DNA binding site [nucleotide binding]; other site 573065010214 HipA-like N-terminal domain; Region: HipA_N; pfam07805 573065010215 HipA-like C-terminal domain; Region: HipA_C; pfam07804 573065010216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573065010217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573065010218 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 573065010219 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573065010220 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573065010221 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065010222 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573065010223 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 573065010224 short chain dehydrogenase; Provisional; Region: PRK06179 573065010225 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 573065010226 NADP binding site [chemical binding]; other site 573065010227 active site 573065010228 steroid binding site; other site 573065010229 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 573065010230 Cupin domain; Region: Cupin_2; pfam07883 573065010231 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573065010232 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 573065010233 putative active site [active] 573065010234 catalytic residue [active] 573065010235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065010236 D-galactonate transporter; Region: 2A0114; TIGR00893 573065010237 putative substrate translocation pore; other site 573065010238 putative addiction module antidote; Region: doc_partner; TIGR02609 573065010239 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 573065010240 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 573065010241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573065010242 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 573065010243 putative dimerization interface [polypeptide binding]; other site 573065010244 putative substrate binding pocket [chemical binding]; other site 573065010245 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065010246 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010247 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573065010248 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 573065010249 classical (c) SDRs; Region: SDR_c; cd05233 573065010250 NAD(P) binding site [chemical binding]; other site 573065010251 active site 573065010252 galactonate dehydratase; Provisional; Region: PRK14017 573065010253 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 573065010254 putative active site pocket [active] 573065010255 putative metal binding site [ion binding]; other site 573065010256 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573065010257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573065010258 DNA-binding site [nucleotide binding]; DNA binding site 573065010259 FCD domain; Region: FCD; pfam07729 573065010260 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 573065010261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065010262 putative substrate translocation pore; other site 573065010263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573065010264 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 573065010265 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 573065010266 Predicted membrane protein [Function unknown]; Region: COG3766 573065010267 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 573065010268 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 573065010269 classical (c) SDRs; Region: SDR_c; cd05233 573065010270 NAD(P) binding site [chemical binding]; other site 573065010271 active site 573065010272 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573065010273 active site 573065010274 Fic family protein [Function unknown]; Region: COG3177 573065010275 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 573065010276 Fic/DOC family; Region: Fic; pfam02661 573065010277 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 573065010278 dimerization interface [polypeptide binding]; other site 573065010279 metal binding site [ion binding]; metal-binding site 573065010280 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 573065010281 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573065010282 NAD binding site [chemical binding]; other site 573065010283 catalytic Zn binding site [ion binding]; other site 573065010284 structural Zn binding site [ion binding]; other site 573065010285 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 573065010286 FecR protein; Region: FecR; pfam04773 573065010287 RNA polymerase factor sigma-70; Validated; Region: PRK09047 573065010288 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065010289 DNA binding residues [nucleotide binding] 573065010290 Secretin and TonB N terminus short domain; Region: STN; smart00965 573065010291 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010292 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065010293 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010294 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 573065010295 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010296 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 573065010297 Predicted membrane protein [Function unknown]; Region: COG2259 573065010298 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 573065010299 hypothetical protein; Provisional; Region: PRK05409 573065010300 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 573065010301 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 573065010302 hypothetical protein; Provisional; Region: PRK05409 573065010303 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 573065010304 RNA polymerase sigma factor; Provisional; Region: PRK12512 573065010305 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065010306 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065010307 DNA binding residues [nucleotide binding] 573065010308 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 573065010309 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 573065010310 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573065010311 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 573065010312 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573065010313 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573065010314 RHS Repeat; Region: RHS_repeat; cl11982 573065010315 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573065010316 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 573065010317 RHS Repeat; Region: RHS_repeat; pfam05593 573065010318 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573065010319 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573065010320 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 573065010321 protein-splicing catalytic site; other site 573065010322 thioester formation/cholesterol transfer; other site 573065010323 Pretoxin HINT domain; Region: PT-HINT; pfam07591 573065010324 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 573065010325 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573065010326 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 573065010327 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 573065010328 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 573065010329 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573065010330 Walker A motif; other site 573065010331 ATP binding site [chemical binding]; other site 573065010332 Walker B motif; other site 573065010333 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 573065010334 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 573065010335 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 573065010336 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 573065010337 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 573065010338 type II secretion system protein D; Region: type_II_gspD; TIGR02517 573065010339 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 573065010340 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 573065010341 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 573065010342 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 573065010343 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573065010344 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573065010345 RHS Repeat; Region: RHS_repeat; pfam05593 573065010346 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 573065010347 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573065010348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 573065010349 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 573065010350 RHS Repeat; Region: RHS_repeat; cl11982 573065010351 RHS Repeat; Region: RHS_repeat; cl11982 573065010352 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 573065010353 RHS Repeat; Region: RHS_repeat; pfam05593 573065010354 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573065010355 MULE transposase domain; Region: MULE; pfam10551 573065010356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573065010357 Transposase; Region: HTH_Tnp_1; cl17663 573065010358 TrwC relaxase; Region: TrwC; pfam08751 573065010359 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 573065010360 AAA domain; Region: AAA_30; pfam13604 573065010361 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 573065010362 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573065010363 Walker A motif; other site 573065010364 ATP binding site [chemical binding]; other site 573065010365 Walker B motif; other site 573065010366 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573065010367 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573065010368 dimer interface [polypeptide binding]; other site 573065010369 ssDNA binding site [nucleotide binding]; other site 573065010370 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573065010371 PemK-like protein; Region: PemK; pfam02452 573065010372 transcription elongation factor regulatory protein; Validated; Region: PRK06342 573065010373 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573065010374 Antirestriction protein; Region: Antirestrict; pfam03230 573065010375 PemK-like protein; Region: PemK; cl00995 573065010376 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 573065010377 RloB-like protein; Region: RloB; pfam13707 573065010378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573065010379 AAA domain; Region: AAA_21; pfam13304 573065010380 Walker A/P-loop; other site 573065010381 ATP binding site [chemical binding]; other site 573065010382 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 573065010383 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 573065010384 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 573065010385 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 573065010386 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573065010387 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 573065010388 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573065010389 Helicase_C-like; Region: Helicase_C_4; pfam13871 573065010390 ParB-like nuclease domain; Region: ParB; smart00470 573065010391 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 573065010392 Toprim domain; Region: Toprim_3; pfam13362 573065010393 VirC1 protein; Region: VirC1; cl17401 573065010394 Replication initiator protein A; Region: RPA; pfam10134 573065010395 Helix-turn-helix domain; Region: HTH_36; pfam13730 573065010396 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573065010397 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573065010398 catalytic residue [active] 573065010399 TraL protein; Region: TraL; cl06278 573065010400 TraE protein; Region: TraE; cl05060 573065010401 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 573065010402 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 573065010403 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 573065010404 dimerization domain [polypeptide binding]; other site 573065010405 dimer interface [polypeptide binding]; other site 573065010406 catalytic residues [active] 573065010407 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 573065010408 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 573065010409 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 573065010410 Domain of unknown function DUF87; Region: DUF87; pfam01935 573065010411 N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; Region: Tweety_N; cl12141 573065010412 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 573065010413 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 573065010414 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 573065010415 TraU protein; Region: TraU; pfam06834 573065010416 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 573065010417 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 573065010418 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 573065010419 F plasmid transfer operon protein; Region: TraF; pfam13728 573065010420 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 573065010421 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 573065010422 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573065010423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573065010424 non-specific DNA binding site [nucleotide binding]; other site 573065010425 salt bridge; other site 573065010426 sequence-specific DNA binding site [nucleotide binding]; other site 573065010427 Predicted transcriptional regulator [Transcription]; Region: COG4957 573065010428 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 573065010429 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 573065010430 active site 573065010431 catalytic site [active] 573065010432 substrate binding site [chemical binding]; other site 573065010433 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573065010434 IHF - DNA interface [nucleotide binding]; other site 573065010435 IHF dimer interface [polypeptide binding]; other site 573065010436 DNA-sulfur modification-associated; Region: DndB; cl17621 573065010437 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 573065010438 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 573065010439 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573065010440 catalytic residue [active] 573065010441 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 573065010442 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 573065010443 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573065010444 active site 573065010445 ATP binding site [chemical binding]; other site 573065010446 substrate binding site [chemical binding]; other site 573065010447 activation loop (A-loop); other site 573065010448 Protein of unknown function DUF262; Region: DUF262; pfam03235 573065010449 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 573065010450 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 573065010451 catalytic residues [active] 573065010452 catalytic nucleophile [active] 573065010453 Presynaptic Site I dimer interface [polypeptide binding]; other site 573065010454 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 573065010455 Synaptic Flat tetramer interface [polypeptide binding]; other site 573065010456 Synaptic Site I dimer interface [polypeptide binding]; other site 573065010457 DNA binding site [nucleotide binding] 573065010458 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 573065010459 DNA-binding interface [nucleotide binding]; DNA binding site 573065010460 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 573065010461 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 573065010462 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573065010463 dimerization interface [polypeptide binding]; other site 573065010464 putative DNA binding site [nucleotide binding]; other site 573065010465 putative Zn2+ binding site [ion binding]; other site 573065010466 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 573065010467 Low molecular weight phosphatase family; Region: LMWPc; cl00105 573065010468 active site 573065010469 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 573065010470 Sodium Bile acid symporter family; Region: SBF; cl17470 573065010471 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 573065010472 ArsC family; Region: ArsC; pfam03960 573065010473 catalytic residues [active] 573065010474 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 573065010475 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573065010476 Low molecular weight phosphatase family; Region: LMWPc; cd00115 573065010477 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 573065010478 active site 573065010479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573065010480 Coenzyme A binding pocket [chemical binding]; other site 573065010481 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 573065010482 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 573065010483 DNA binding residues [nucleotide binding] 573065010484 dimer interface [polypeptide binding]; other site 573065010485 putative metal binding site [ion binding]; other site 573065010486 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573065010487 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 573065010488 metal-binding site [ion binding] 573065010489 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573065010490 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573065010491 MULE transposase domain; Region: MULE; pfam10551 573065010492 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 573065010493 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 573065010494 Multicopper oxidase; Region: Cu-oxidase; pfam00394 573065010495 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 573065010496 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573065010497 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 573065010498 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 573065010499 dimer interface [polypeptide binding]; other site 573065010500 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573065010501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573065010502 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573065010503 DNA binding residues [nucleotide binding] 573065010504 Outer membrane efflux protein; Region: OEP; pfam02321 573065010505 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 573065010506 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065010507 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 573065010508 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 573065010509 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 573065010510 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 573065010511 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 573065010512 putative homodimer interface [polypeptide binding]; other site 573065010513 putative homotetramer interface [polypeptide binding]; other site 573065010514 putative allosteric switch controlling residues; other site 573065010515 putative metal binding site [ion binding]; other site 573065010516 putative homodimer-homodimer interface [polypeptide binding]; other site 573065010517 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573065010518 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573065010519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573065010520 motif II; other site 573065010521 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573065010522 Domain of unknown function (DUF305); Region: DUF305; cl17794 573065010523 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 573065010524 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573065010525 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573065010526 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 573065010527 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 573065010528 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 573065010529 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 573065010530 HlyD family secretion protein; Region: HlyD_3; pfam13437 573065010531 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538