-- dump date 20140618_205820 -- class Genbank::misc_feature -- table misc_feature_note -- id note 521095000001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521095000002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095000003 ATP binding site [chemical binding]; other site 521095000004 Mg2+ binding site [ion binding]; other site 521095000005 G-X-G motif; other site 521095000006 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 521095000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095000008 Walker A motif; other site 521095000009 ATP binding site [chemical binding]; other site 521095000010 Walker B motif; other site 521095000011 arginine finger; other site 521095000012 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 521095000013 DnaA box-binding interface [nucleotide binding]; other site 521095000014 DNA polymerase III subunit beta; Validated; Region: PRK05643 521095000015 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 521095000016 putative DNA binding surface [nucleotide binding]; other site 521095000017 dimer interface [polypeptide binding]; other site 521095000018 beta-clamp/clamp loader binding surface; other site 521095000019 beta-clamp/translesion DNA polymerase binding surface; other site 521095000020 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 521095000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095000022 Walker A/P-loop; other site 521095000023 ATP binding site [chemical binding]; other site 521095000024 Q-loop/lid; other site 521095000025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095000026 ABC transporter signature motif; other site 521095000027 Walker B; other site 521095000028 D-loop; other site 521095000029 H-loop/switch region; other site 521095000030 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 521095000031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095000032 Mg2+ binding site [ion binding]; other site 521095000033 G-X-G motif; other site 521095000034 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 521095000035 anchoring element; other site 521095000036 dimer interface [polypeptide binding]; other site 521095000037 ATP binding site [chemical binding]; other site 521095000038 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 521095000039 active site 521095000040 putative metal-binding site [ion binding]; other site 521095000041 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 521095000042 DNA gyrase subunit A; Validated; Region: PRK05560 521095000043 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 521095000044 CAP-like domain; other site 521095000045 active site 521095000046 primary dimer interface [polypeptide binding]; other site 521095000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 521095000053 Bifunctional nuclease; Region: DNase-RNase; pfam02577 521095000054 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 521095000055 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 521095000056 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 521095000057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095000058 dimer interface [polypeptide binding]; other site 521095000059 conserved gate region; other site 521095000060 putative PBP binding loops; other site 521095000061 ABC-ATPase subunit interface; other site 521095000062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095000063 dimer interface [polypeptide binding]; other site 521095000064 conserved gate region; other site 521095000065 putative PBP binding loops; other site 521095000066 ABC-ATPase subunit interface; other site 521095000067 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 521095000068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095000069 Walker A/P-loop; other site 521095000070 ATP binding site [chemical binding]; other site 521095000071 Q-loop/lid; other site 521095000072 ABC transporter signature motif; other site 521095000073 Walker B; other site 521095000074 D-loop; other site 521095000075 H-loop/switch region; other site 521095000076 TOBE domain; Region: TOBE_2; pfam08402 521095000077 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521095000078 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521095000079 DNA binding site [nucleotide binding] 521095000080 domain linker motif; other site 521095000081 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 521095000082 putative dimerization interface [polypeptide binding]; other site 521095000083 putative ligand binding site [chemical binding]; other site 521095000084 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 521095000085 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 521095000086 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 521095000087 G1 box; other site 521095000088 putative GEF interaction site [polypeptide binding]; other site 521095000089 GTP/Mg2+ binding site [chemical binding]; other site 521095000090 Switch I region; other site 521095000091 G2 box; other site 521095000092 G3 box; other site 521095000093 Switch II region; other site 521095000094 G4 box; other site 521095000095 G5 box; other site 521095000096 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 521095000097 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 521095000098 Predicted membrane protein [Function unknown]; Region: COG2860 521095000099 UPF0126 domain; Region: UPF0126; pfam03458 521095000100 UPF0126 domain; Region: UPF0126; pfam03458 521095000101 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 521095000102 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 521095000103 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 521095000104 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 521095000105 dimer interface [polypeptide binding]; other site 521095000106 ssDNA binding site [nucleotide binding]; other site 521095000107 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521095000108 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 521095000109 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 521095000110 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 521095000111 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 521095000112 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 521095000113 replicative DNA helicase; Region: DnaB; TIGR00665 521095000114 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 521095000115 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 521095000116 Walker A motif; other site 521095000117 ATP binding site [chemical binding]; other site 521095000118 Walker B motif; other site 521095000119 DNA binding loops [nucleotide binding] 521095000120 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 521095000121 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 521095000122 GDP-binding site [chemical binding]; other site 521095000123 ACT binding site; other site 521095000124 IMP binding site; other site 521095000125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 521095000126 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 521095000127 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 521095000128 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 521095000129 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 521095000130 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 521095000131 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 521095000132 dimer interface [polypeptide binding]; other site 521095000133 ADP-ribose binding site [chemical binding]; other site 521095000134 active site 521095000135 nudix motif; other site 521095000136 metal binding site [ion binding]; metal-binding site 521095000137 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095000138 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095000139 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 521095000140 Walker A/P-loop; other site 521095000141 ATP binding site [chemical binding]; other site 521095000142 Q-loop/lid; other site 521095000143 ABC transporter signature motif; other site 521095000144 Walker B; other site 521095000145 D-loop; other site 521095000146 H-loop/switch region; other site 521095000147 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 521095000148 dimer interface [polypeptide binding]; other site 521095000149 pyridoxal binding site [chemical binding]; other site 521095000150 ATP binding site [chemical binding]; other site 521095000151 AIR carboxylase; Region: AIRC; pfam00731 521095000152 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 521095000153 active site 521095000154 catalytic site [active] 521095000155 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 521095000156 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 521095000157 active site 521095000158 tetramer interface [polypeptide binding]; other site 521095000159 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095000160 active site 521095000161 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 521095000162 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 521095000163 dimerization interface [polypeptide binding]; other site 521095000164 putative ATP binding site [chemical binding]; other site 521095000165 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 521095000166 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 521095000167 active site 521095000168 substrate binding site [chemical binding]; other site 521095000169 cosubstrate binding site; other site 521095000170 catalytic site [active] 521095000171 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 521095000172 Flavin Reductases; Region: FlaRed; cl00801 521095000173 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 521095000174 classical (c) SDRs; Region: SDR_c; cd05233 521095000175 NAD(P) binding site [chemical binding]; other site 521095000176 active site 521095000177 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 521095000178 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 521095000179 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 521095000180 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 521095000181 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 521095000182 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 521095000183 CAAX protease self-immunity; Region: Abi; pfam02517 521095000184 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 521095000185 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521095000186 EXLDI protein; Region: EXLDI; TIGR04342 521095000187 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 521095000188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095000189 S-adenosylmethionine binding site [chemical binding]; other site 521095000190 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 521095000191 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 521095000192 NAD(P) binding site [chemical binding]; other site 521095000193 LDH/MDH dimer interface [polypeptide binding]; other site 521095000194 substrate binding site [chemical binding]; other site 521095000195 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 521095000196 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 521095000197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 521095000198 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 521095000199 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521095000200 Walker A/P-loop; other site 521095000201 ATP binding site [chemical binding]; other site 521095000202 Q-loop/lid; other site 521095000203 ABC transporter signature motif; other site 521095000204 Walker B; other site 521095000205 D-loop; other site 521095000206 H-loop/switch region; other site 521095000207 elongation factor G; Reviewed; Region: PRK12740 521095000208 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 521095000209 G1 box; other site 521095000210 putative GEF interaction site [polypeptide binding]; other site 521095000211 GTP/Mg2+ binding site [chemical binding]; other site 521095000212 Switch I region; other site 521095000213 G2 box; other site 521095000214 G3 box; other site 521095000215 Switch II region; other site 521095000216 G4 box; other site 521095000217 G5 box; other site 521095000218 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 521095000219 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 521095000220 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 521095000221 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 521095000222 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 521095000223 TPP-binding site; other site 521095000224 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521095000225 PYR/PP interface [polypeptide binding]; other site 521095000226 dimer interface [polypeptide binding]; other site 521095000227 TPP binding site [chemical binding]; other site 521095000228 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521095000229 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 521095000230 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 521095000231 dimer interface [polypeptide binding]; other site 521095000232 active site 521095000233 metal binding site [ion binding]; metal-binding site 521095000234 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521095000235 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 521095000236 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521095000237 Flavodoxin; Region: Flavodoxin_1; pfam00258 521095000238 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 521095000239 Domain of unknown function DUF21; Region: DUF21; pfam01595 521095000240 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 521095000241 Transporter associated domain; Region: CorC_HlyC; smart01091 521095000242 cyanophycin synthetase; Provisional; Region: PRK14016 521095000243 YtxH-like protein; Region: YtxH; pfam12732 521095000244 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 521095000245 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 521095000246 PRC-barrel domain; Region: PRC; pfam05239 521095000247 MgtE intracellular N domain; Region: MgtE_N; pfam03448 521095000248 FOG: CBS domain [General function prediction only]; Region: COG0517 521095000249 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 521095000250 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 521095000251 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 521095000252 nucleoside/Zn binding site; other site 521095000253 dimer interface [polypeptide binding]; other site 521095000254 catalytic motif [active] 521095000255 PUA domain; Region: PUA; cl00607 521095000256 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 521095000257 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 521095000258 putative RNA binding site [nucleotide binding]; other site 521095000259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095000260 S-adenosylmethionine binding site [chemical binding]; other site 521095000261 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 521095000262 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 521095000263 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521095000264 ATP binding site [chemical binding]; other site 521095000265 Mg++ binding site [ion binding]; other site 521095000266 motif III; other site 521095000267 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095000268 nucleotide binding region [chemical binding]; other site 521095000269 ATP-binding site [chemical binding]; other site 521095000270 homoserine O-succinyltransferase; Provisional; Region: PRK05368 521095000271 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 521095000272 proposed active site lysine [active] 521095000273 conserved cys residue [active] 521095000274 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 521095000275 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521095000276 active site 521095000277 metal binding site [ion binding]; metal-binding site 521095000278 homotetramer interface [polypeptide binding]; other site 521095000279 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 521095000280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095000281 DNA-binding site [nucleotide binding]; DNA binding site 521095000282 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 521095000283 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 521095000284 beta-galactosidase; Region: BGL; TIGR03356 521095000285 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 521095000286 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 521095000287 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 521095000288 active site 521095000289 P-loop; other site 521095000290 phosphorylation site [posttranslational modification] 521095000291 methionine cluster; other site 521095000292 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 521095000293 active site 521095000294 phosphorylation site [posttranslational modification] 521095000295 metal binding site [ion binding]; metal-binding site 521095000296 Double zinc ribbon; Region: DZR; pfam12773 521095000297 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 521095000298 asparagine synthetase AsnA; Provisional; Region: PRK05425 521095000299 motif 1; other site 521095000300 dimer interface [polypeptide binding]; other site 521095000301 active site 521095000302 motif 2; other site 521095000303 motif 3; other site 521095000304 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 521095000305 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 521095000306 dimerization interface [polypeptide binding]; other site 521095000307 DPS ferroxidase diiron center [ion binding]; other site 521095000308 ion pore; other site 521095000309 4Fe-4S binding domain; Region: Fer4_5; pfam12801 521095000310 4Fe-4S binding domain; Region: Fer4_5; pfam12801 521095000311 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 521095000312 4Fe-4S binding domain; Region: Fer4; cl02805 521095000313 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 521095000314 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521095000315 catalytic residues [active] 521095000316 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521095000317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095000318 active site 521095000319 phosphorylation site [posttranslational modification] 521095000320 intermolecular recognition site; other site 521095000321 dimerization interface [polypeptide binding]; other site 521095000322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095000323 DNA binding site [nucleotide binding] 521095000324 HAMP domain; Region: HAMP; pfam00672 521095000325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521095000326 dimer interface [polypeptide binding]; other site 521095000327 phosphorylation site [posttranslational modification] 521095000328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095000329 ATP binding site [chemical binding]; other site 521095000330 Mg2+ binding site [ion binding]; other site 521095000331 G-X-G motif; other site 521095000332 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 521095000333 active site 521095000334 intersubunit interactions; other site 521095000335 catalytic residue [active] 521095000336 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 521095000337 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 521095000338 nucleotide binding site [chemical binding]; other site 521095000339 NEF interaction site [polypeptide binding]; other site 521095000340 SBD interface [polypeptide binding]; other site 521095000341 GrpE; Region: GrpE; pfam01025 521095000342 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 521095000343 dimer interface [polypeptide binding]; other site 521095000344 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 521095000345 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 521095000346 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521095000347 HSP70 interaction site [polypeptide binding]; other site 521095000348 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521095000349 substrate binding site [polypeptide binding]; other site 521095000350 dimer interface [polypeptide binding]; other site 521095000351 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 521095000352 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 521095000353 DNA binding residues [nucleotide binding] 521095000354 putative dimer interface [polypeptide binding]; other site 521095000355 RelB antitoxin; Region: RelB; cl01171 521095000356 PIN domain; Region: PIN_3; pfam13470 521095000357 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 521095000358 Clp amino terminal domain; Region: Clp_N; pfam02861 521095000359 Clp amino terminal domain; Region: Clp_N; pfam02861 521095000360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095000361 Walker A motif; other site 521095000362 ATP binding site [chemical binding]; other site 521095000363 Walker B motif; other site 521095000364 arginine finger; other site 521095000365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095000366 Walker A motif; other site 521095000367 ATP binding site [chemical binding]; other site 521095000368 Walker B motif; other site 521095000369 arginine finger; other site 521095000370 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 521095000371 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 521095000372 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 521095000373 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 521095000374 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 521095000375 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 521095000376 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 521095000377 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 521095000378 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 521095000379 sugar binding site [chemical binding]; other site 521095000380 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 521095000381 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 521095000382 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 521095000383 putative dimer interface [polypeptide binding]; other site 521095000384 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 521095000385 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 521095000386 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 521095000387 TilS substrate C-terminal domain; Region: TilS_C; smart00977 521095000388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095000389 active site 521095000390 aspartate aminotransferase; Provisional; Region: PRK06836 521095000391 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521095000392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095000393 homodimer interface [polypeptide binding]; other site 521095000394 catalytic residue [active] 521095000395 putative hydrolase; Validated; Region: PRK09248 521095000396 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 521095000397 active site 521095000398 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 521095000399 active site 521095000400 putative catalytic site [active] 521095000401 DNA binding site [nucleotide binding] 521095000402 putative phosphate binding site [ion binding]; other site 521095000403 metal binding site A [ion binding]; metal-binding site 521095000404 AP binding site [nucleotide binding]; other site 521095000405 metal binding site B [ion binding]; metal-binding site 521095000406 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 521095000407 dihydropteroate synthase; Region: DHPS; TIGR01496 521095000408 substrate binding pocket [chemical binding]; other site 521095000409 dimer interface [polypeptide binding]; other site 521095000410 inhibitor binding site; inhibition site 521095000411 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 521095000412 catalytic center binding site [active] 521095000413 ATP binding site [chemical binding]; other site 521095000414 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 521095000415 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 521095000416 nucleotide binding site [chemical binding]; other site 521095000417 Type III pantothenate kinase; Region: Pan_kinase; cl17198 521095000418 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 521095000419 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 521095000420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095000421 Walker A motif; other site 521095000422 ATP binding site [chemical binding]; other site 521095000423 Walker B motif; other site 521095000424 arginine finger; other site 521095000425 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 521095000426 hypothetical protein; Validated; Region: PRK00153 521095000427 recombination protein RecR; Reviewed; Region: recR; PRK00076 521095000428 RecR protein; Region: RecR; pfam02132 521095000429 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 521095000430 putative active site [active] 521095000431 putative metal-binding site [ion binding]; other site 521095000432 tetramer interface [polypeptide binding]; other site 521095000433 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 521095000434 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 521095000435 Rrf2 family protein; Region: rrf2_super; TIGR00738 521095000436 Transcriptional regulator; Region: Rrf2; pfam02082 521095000437 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521095000438 endonuclease III; Region: ENDO3c; smart00478 521095000439 minor groove reading motif; other site 521095000440 helix-hairpin-helix signature motif; other site 521095000441 active site 521095000442 Rubrerythrin [Energy production and conversion]; Region: COG1592 521095000443 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 521095000444 binuclear metal center [ion binding]; other site 521095000445 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 521095000446 iron binding site [ion binding]; other site 521095000447 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 521095000448 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 521095000449 minor groove reading motif; other site 521095000450 helix-hairpin-helix signature motif; other site 521095000451 substrate binding pocket [chemical binding]; other site 521095000452 active site 521095000453 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 521095000454 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 521095000455 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 521095000456 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521095000457 ATP binding site [chemical binding]; other site 521095000458 putative Mg++ binding site [ion binding]; other site 521095000459 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095000460 nucleotide binding region [chemical binding]; other site 521095000461 ATP-binding site [chemical binding]; other site 521095000462 TRCF domain; Region: TRCF; pfam03461 521095000463 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 521095000464 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 521095000465 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 521095000466 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 521095000467 homodimer interface [polypeptide binding]; other site 521095000468 metal binding site [ion binding]; metal-binding site 521095000469 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 521095000470 homodimer interface [polypeptide binding]; other site 521095000471 active site 521095000472 putative chemical substrate binding site [chemical binding]; other site 521095000473 metal binding site [ion binding]; metal-binding site 521095000474 exopolyphosphatase; Region: exo_poly_only; TIGR03706 521095000475 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 521095000476 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 521095000477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095000478 DNA-binding site [nucleotide binding]; DNA binding site 521095000479 UTRA domain; Region: UTRA; pfam07702 521095000480 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 521095000481 TPP-binding site [chemical binding]; other site 521095000482 dimer interface [polypeptide binding]; other site 521095000483 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 521095000484 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521095000485 PYR/PP interface [polypeptide binding]; other site 521095000486 dimer interface [polypeptide binding]; other site 521095000487 TPP binding site [chemical binding]; other site 521095000488 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521095000489 peptide S-glycosyltransferase, SunS family; Region: S_glycosyl_SunS; TIGR04195 521095000490 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 521095000491 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 521095000492 putative active site [active] 521095000493 metal binding site [ion binding]; metal-binding site 521095000494 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 521095000495 intersubunit interface [polypeptide binding]; other site 521095000496 active site 521095000497 catalytic residue [active] 521095000498 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 521095000499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095000500 FeS/SAM binding site; other site 521095000501 hypothetical protein; Provisional; Region: PRK10977 521095000502 Pyruvate formate lyase; Region: PFL; pfam02901 521095000503 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 521095000504 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 521095000505 ligand binding site [chemical binding]; other site 521095000506 flexible hinge region; other site 521095000507 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 521095000508 putative switch regulator; other site 521095000509 non-specific DNA interactions [nucleotide binding]; other site 521095000510 DNA binding site [nucleotide binding] 521095000511 sequence specific DNA binding site [nucleotide binding]; other site 521095000512 putative cAMP binding site [chemical binding]; other site 521095000513 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 521095000514 putative kinase; Provisional; Region: PRK09954 521095000515 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 521095000516 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 521095000517 substrate binding site [chemical binding]; other site 521095000518 ATP binding site [chemical binding]; other site 521095000519 phosphopentomutase; Provisional; Region: PRK05362 521095000520 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 521095000521 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 521095000522 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 521095000523 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 521095000524 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 521095000525 ligand binding site [chemical binding]; other site 521095000526 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 521095000527 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 521095000528 Walker A/P-loop; other site 521095000529 ATP binding site [chemical binding]; other site 521095000530 Q-loop/lid; other site 521095000531 ABC transporter signature motif; other site 521095000532 Walker B; other site 521095000533 D-loop; other site 521095000534 H-loop/switch region; other site 521095000535 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 521095000536 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521095000537 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521095000538 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521095000539 TM-ABC transporter signature motif; other site 521095000540 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521095000541 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 521095000542 TM-ABC transporter signature motif; other site 521095000543 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 521095000544 active site 521095000545 catalytic motif [active] 521095000546 Zn binding site [ion binding]; other site 521095000547 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 521095000548 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 521095000549 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 521095000550 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 521095000551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521095000552 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 521095000553 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 521095000554 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 521095000555 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 521095000556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 521095000557 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 521095000558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 521095000559 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521095000560 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521095000561 DNA binding site [nucleotide binding] 521095000562 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521095000563 ligand binding site [chemical binding]; other site 521095000564 dimerization interface [polypeptide binding]; other site 521095000565 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 521095000566 active site 521095000567 P-loop; other site 521095000568 phosphorylation site [posttranslational modification] 521095000569 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 521095000570 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 521095000571 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521095000572 active site 521095000573 phosphorylation site [posttranslational modification] 521095000574 peptidase T; Region: peptidase-T; TIGR01882 521095000575 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 521095000576 metal binding site [ion binding]; metal-binding site 521095000577 dimer interface [polypeptide binding]; other site 521095000578 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521095000579 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 521095000580 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 521095000581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521095000582 active site 521095000583 motif I; other site 521095000584 motif II; other site 521095000585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 521095000586 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 521095000587 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 521095000588 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 521095000589 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 521095000590 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 521095000591 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 521095000592 ribonuclease PH; Reviewed; Region: rph; PRK00173 521095000593 Ribonuclease PH; Region: RNase_PH_bact; cd11362 521095000594 hexamer interface [polypeptide binding]; other site 521095000595 active site 521095000596 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 521095000597 active site 521095000598 dimerization interface [polypeptide binding]; other site 521095000599 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 521095000600 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 521095000601 active site 521095000602 trimer interface [polypeptide binding]; other site 521095000603 allosteric site; other site 521095000604 active site lid [active] 521095000605 hexamer (dimer of trimers) interface [polypeptide binding]; other site 521095000606 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 521095000607 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 521095000608 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 521095000609 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 521095000610 transketolase; Reviewed; Region: PRK05899 521095000611 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 521095000612 TPP-binding site [chemical binding]; other site 521095000613 dimer interface [polypeptide binding]; other site 521095000614 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 521095000615 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521095000616 PYR/PP interface [polypeptide binding]; other site 521095000617 dimer interface [polypeptide binding]; other site 521095000618 TPP binding site [chemical binding]; other site 521095000619 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521095000620 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 521095000621 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 521095000622 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 521095000623 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 521095000624 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 521095000625 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 521095000626 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 521095000627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521095000628 Coenzyme A binding pocket [chemical binding]; other site 521095000629 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 521095000630 Glycoprotease family; Region: Peptidase_M22; pfam00814 521095000631 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 521095000632 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 521095000633 UGMP family protein; Validated; Region: PRK09604 521095000634 NAD synthetase; Reviewed; Region: nadE; PRK02628 521095000635 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 521095000636 multimer interface [polypeptide binding]; other site 521095000637 active site 521095000638 catalytic triad [active] 521095000639 protein interface 1 [polypeptide binding]; other site 521095000640 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 521095000641 homodimer interface [polypeptide binding]; other site 521095000642 NAD binding pocket [chemical binding]; other site 521095000643 ATP binding pocket [chemical binding]; other site 521095000644 Mg binding site [ion binding]; other site 521095000645 active-site loop [active] 521095000646 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 521095000647 oligomerisation interface [polypeptide binding]; other site 521095000648 mobile loop; other site 521095000649 roof hairpin; other site 521095000650 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 521095000651 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 521095000652 ring oligomerisation interface [polypeptide binding]; other site 521095000653 ATP/Mg binding site [chemical binding]; other site 521095000654 stacking interactions; other site 521095000655 hinge regions; other site 521095000656 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 521095000657 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 521095000658 GTP-binding protein YchF; Reviewed; Region: PRK09601 521095000659 YchF GTPase; Region: YchF; cd01900 521095000660 G1 box; other site 521095000661 GTP/Mg2+ binding site [chemical binding]; other site 521095000662 Switch I region; other site 521095000663 G2 box; other site 521095000664 Switch II region; other site 521095000665 G3 box; other site 521095000666 G4 box; other site 521095000667 G5 box; other site 521095000668 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 521095000669 Transcriptional regulator [Transcription]; Region: LytR; COG1316 521095000670 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 521095000671 Cna protein B-type domain; Region: Cna_B; pfam05738 521095000672 GMP synthase; Reviewed; Region: guaA; PRK00074 521095000673 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 521095000674 AMP/PPi binding site [chemical binding]; other site 521095000675 candidate oxyanion hole; other site 521095000676 catalytic triad [active] 521095000677 potential glutamine specificity residues [chemical binding]; other site 521095000678 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 521095000679 ATP Binding subdomain [chemical binding]; other site 521095000680 Ligand Binding sites [chemical binding]; other site 521095000681 Dimerization subdomain; other site 521095000682 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 521095000683 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 521095000684 active site 521095000685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095000686 Walker A/P-loop; other site 521095000687 ATP binding site [chemical binding]; other site 521095000688 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521095000689 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 521095000690 active site 521095000691 DNA binding site [nucleotide binding] 521095000692 Int/Topo IB signature motif; other site 521095000693 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 521095000694 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 521095000695 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 521095000696 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 521095000697 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521095000698 putative Mg++ binding site [ion binding]; other site 521095000699 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 521095000700 Pre-mRNA-splicing factor of RES complex; Region: Bud13; pfam09736 521095000701 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 521095000702 HsdM N-terminal domain; Region: HsdM_N; pfam12161 521095000703 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 521095000704 Methyltransferase domain; Region: Methyltransf_26; pfam13659 521095000705 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 521095000706 Mu-like prophage protein [General function prediction only]; Region: COG3941 521095000707 Helix-turn-helix domain; Region: HTH_17; pfam12728 521095000708 Fic family protein [Function unknown]; Region: COG3177 521095000709 Fic/DOC family; Region: Fic; pfam02661 521095000710 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 521095000711 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 521095000712 glutaminase active site [active] 521095000713 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 521095000714 dimer interface [polypeptide binding]; other site 521095000715 active site 521095000716 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 521095000717 dimer interface [polypeptide binding]; other site 521095000718 active site 521095000719 Predicted transcriptional regulators [Transcription]; Region: COG1695 521095000720 Transcriptional regulator PadR-like family; Region: PadR; cl17335 521095000721 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 521095000722 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 521095000723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521095000724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095000725 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521095000726 Walker A/P-loop; other site 521095000727 ATP binding site [chemical binding]; other site 521095000728 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 521095000729 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 521095000730 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 521095000731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521095000732 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 521095000733 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 521095000734 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 521095000735 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521095000736 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521095000737 Walker A/P-loop; other site 521095000738 ATP binding site [chemical binding]; other site 521095000739 Q-loop/lid; other site 521095000740 ABC transporter signature motif; other site 521095000741 Walker B; other site 521095000742 D-loop; other site 521095000743 H-loop/switch region; other site 521095000744 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 521095000745 catalytic triad [active] 521095000746 active site nucleophile [active] 521095000747 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 521095000748 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095000749 DNA-binding site [nucleotide binding]; DNA binding site 521095000750 Predicted membrane protein [General function prediction only]; Region: COG4194 521095000751 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 521095000752 RelB antitoxin; Region: RelB; cl01171 521095000753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 521095000754 Predicted transcriptional regulator [Transcription]; Region: COG1959 521095000755 Transcriptional regulator; Region: Rrf2; pfam02082 521095000756 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 521095000757 Isochorismatase family; Region: Isochorismatase; pfam00857 521095000758 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 521095000759 catalytic triad [active] 521095000760 conserved cis-peptide bond; other site 521095000761 flavodoxin; Provisional; Region: PRK06242 521095000762 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 521095000763 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 521095000764 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095000765 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521095000766 Walker A/P-loop; other site 521095000767 ATP binding site [chemical binding]; other site 521095000768 Q-loop/lid; other site 521095000769 ABC transporter signature motif; other site 521095000770 Walker B; other site 521095000771 D-loop; other site 521095000772 H-loop/switch region; other site 521095000773 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521095000774 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521095000775 FtsX-like permease family; Region: FtsX; pfam02687 521095000776 Uncharacterized conserved protein [Function unknown]; Region: COG2014 521095000777 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 521095000778 Domain of unknown function (DUF364); Region: DUF364; pfam04016 521095000779 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 521095000780 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 521095000781 metal binding site [ion binding]; metal-binding site 521095000782 dimer interface [polypeptide binding]; other site 521095000783 xanthine permease; Region: pbuX; TIGR03173 521095000784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 521095000785 YheO-like PAS domain; Region: PAS_6; pfam08348 521095000786 HTH domain; Region: HTH_22; pfam13309 521095000787 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 521095000788 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521095000789 active site 521095000790 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 521095000791 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521095000792 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 521095000793 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 521095000794 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 521095000795 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 521095000796 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 521095000797 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 521095000798 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 521095000799 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521095000800 catalytic residue [active] 521095000801 peptidase; Reviewed; Region: PRK13004 521095000802 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 521095000803 putative metal binding site [ion binding]; other site 521095000804 putative dimer interface [polypeptide binding]; other site 521095000805 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 521095000806 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 521095000807 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 521095000808 carbamate kinase; Reviewed; Region: PRK12686 521095000809 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 521095000810 putative substrate binding site [chemical binding]; other site 521095000811 nucleotide binding site [chemical binding]; other site 521095000812 nucleotide binding site [chemical binding]; other site 521095000813 homodimer interface [polypeptide binding]; other site 521095000814 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 521095000815 Ligand binding site; other site 521095000816 metal-binding site 521095000817 phenylhydantoinase; Validated; Region: PRK08323 521095000818 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 521095000819 tetramer interface [polypeptide binding]; other site 521095000820 active site 521095000821 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 521095000822 homotrimer interaction site [polypeptide binding]; other site 521095000823 putative active site [active] 521095000824 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 521095000825 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 521095000826 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 521095000827 CPxP motif; other site 521095000828 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 521095000829 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521095000830 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521095000831 catalytic residue [active] 521095000832 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 521095000833 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 521095000834 selenium donor protein; Region: selD; TIGR00476 521095000835 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 521095000836 dimerization interface [polypeptide binding]; other site 521095000837 putative ATP binding site [chemical binding]; other site 521095000838 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 521095000839 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 521095000840 XdhC Rossmann domain; Region: XdhC_C; pfam13478 521095000841 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 521095000842 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 521095000843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095000844 dimer interface [polypeptide binding]; other site 521095000845 conserved gate region; other site 521095000846 putative PBP binding loops; other site 521095000847 ABC-ATPase subunit interface; other site 521095000848 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 521095000849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095000850 Walker A/P-loop; other site 521095000851 ATP binding site [chemical binding]; other site 521095000852 Q-loop/lid; other site 521095000853 ABC transporter signature motif; other site 521095000854 Walker B; other site 521095000855 D-loop; other site 521095000856 H-loop/switch region; other site 521095000857 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 521095000858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095000859 FeS/SAM binding site; other site 521095000860 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 521095000861 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 521095000862 trimer interface [polypeptide binding]; other site 521095000863 dimer interface [polypeptide binding]; other site 521095000864 putative active site [active] 521095000865 MOSC domain; Region: MOSC; pfam03473 521095000866 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 521095000867 putative MPT binding site; other site 521095000868 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 521095000869 MPT binding site; other site 521095000870 trimer interface [polypeptide binding]; other site 521095000871 Predicted flavoprotein [General function prediction only]; Region: COG0431 521095000872 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 521095000873 PAS domain; Region: PAS_10; pfam13596 521095000874 Predicted flavoprotein [General function prediction only]; Region: COG0431 521095000875 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 521095000876 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 521095000877 ApbE family; Region: ApbE; pfam02424 521095000878 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 521095000879 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 521095000880 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521095000881 Zn2+ binding site [ion binding]; other site 521095000882 Mg2+ binding site [ion binding]; other site 521095000883 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 521095000884 substrate binding site [chemical binding]; other site 521095000885 THF binding site; other site 521095000886 zinc-binding site [ion binding]; other site 521095000887 Predicted transcriptional regulator [Transcription]; Region: COG2378 521095000888 WYL domain; Region: WYL; pfam13280 521095000889 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 521095000890 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521095000891 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 521095000892 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 521095000893 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095000894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095000895 Walker A/P-loop; other site 521095000896 ATP binding site [chemical binding]; other site 521095000897 Q-loop/lid; other site 521095000898 ABC transporter signature motif; other site 521095000899 Walker B; other site 521095000900 D-loop; other site 521095000901 H-loop/switch region; other site 521095000902 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095000903 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095000904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095000905 Walker A/P-loop; other site 521095000906 ATP binding site [chemical binding]; other site 521095000907 Q-loop/lid; other site 521095000908 ABC transporter signature motif; other site 521095000909 Walker B; other site 521095000910 D-loop; other site 521095000911 H-loop/switch region; other site 521095000912 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 521095000913 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 521095000914 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 521095000915 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 521095000916 ABC-ATPase subunit interface; other site 521095000917 dimer interface [polypeptide binding]; other site 521095000918 putative PBP binding regions; other site 521095000919 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 521095000920 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 521095000921 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 521095000922 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 521095000923 metal binding site [ion binding]; metal-binding site 521095000924 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 521095000925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 521095000926 NAD(P) binding site [chemical binding]; other site 521095000927 active site 521095000928 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 521095000929 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521095000930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521095000931 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 521095000932 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 521095000933 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 521095000934 Sulfatase; Region: Sulfatase; cl17466 521095000935 Domain of unknown function (DUF3825); Region: DUF3825; pfam12873 521095000936 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 521095000937 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 521095000938 putative active site [active] 521095000939 catalytic site [active] 521095000940 putative metal binding site [ion binding]; other site 521095000941 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 521095000942 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095000943 Soluble P-type ATPase [General function prediction only]; Region: COG4087 521095000944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095000945 S-adenosylmethionine binding site [chemical binding]; other site 521095000946 5'-nucleotidase; Provisional; Region: PRK03826 521095000947 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 521095000948 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521095000949 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 521095000950 active site 521095000951 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 521095000952 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 521095000953 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 521095000954 NAD-dependent deacetylase; Provisional; Region: PRK00481 521095000955 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 521095000956 NAD+ binding site [chemical binding]; other site 521095000957 substrate binding site [chemical binding]; other site 521095000958 Zn binding site [ion binding]; other site 521095000959 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 521095000960 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 521095000961 DRTGG domain; Region: DRTGG; pfam07085 521095000962 CBS domain; Region: CBS; pfam00571 521095000963 DHH family; Region: DHH; pfam01368 521095000964 DHHA2 domain; Region: DHHA2; pfam02833 521095000965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 521095000966 MORN repeat; Region: MORN; pfam02493 521095000967 Acyltransferase family; Region: Acyl_transf_3; pfam01757 521095000968 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 521095000969 active site 521095000970 catalytic triad [active] 521095000971 oxyanion hole [active] 521095000972 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 521095000973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095000974 Walker A/P-loop; other site 521095000975 ATP binding site [chemical binding]; other site 521095000976 Q-loop/lid; other site 521095000977 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521095000978 ABC transporter; Region: ABC_tran_2; pfam12848 521095000979 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521095000980 Ferritin-like domain; Region: Ferritin; pfam00210 521095000981 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 521095000982 ferroxidase diiron center [ion binding]; other site 521095000983 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 521095000984 EamA-like transporter family; Region: EamA; pfam00892 521095000985 EamA-like transporter family; Region: EamA; pfam00892 521095000986 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 521095000987 active site 521095000988 homodimer interface [polypeptide binding]; other site 521095000989 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 521095000990 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 521095000991 active site 521095000992 hypothetical protein; Provisional; Region: PRK13663 521095000993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 521095000994 Peptidyl-tRNA hydrolase PTH2; Region: PTH2; pfam01981 521095000995 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 521095000996 dimer interface [polypeptide binding]; other site 521095000997 putative active site [active] 521095000998 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 521095000999 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095001000 non-specific DNA binding site [nucleotide binding]; other site 521095001001 salt bridge; other site 521095001002 sequence-specific DNA binding site [nucleotide binding]; other site 521095001003 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 521095001004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521095001005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521095001006 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 521095001007 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 521095001008 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 521095001009 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 521095001010 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 521095001011 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 521095001012 active site 521095001013 Zn binding site [ion binding]; other site 521095001014 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 521095001015 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521095001016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095001017 homodimer interface [polypeptide binding]; other site 521095001018 catalytic residue [active] 521095001019 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 521095001020 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 521095001021 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521095001022 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521095001023 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 521095001024 nucleotide binding site [chemical binding]; other site 521095001025 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 521095001026 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 521095001027 active site 521095001028 P-loop; other site 521095001029 phosphorylation site [posttranslational modification] 521095001030 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 521095001031 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 521095001032 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 521095001033 putative substrate binding site [chemical binding]; other site 521095001034 putative ATP binding site [chemical binding]; other site 521095001035 hypothetical protein; Validated; Region: PRK00110 521095001036 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 521095001037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095001038 DNA-binding site [nucleotide binding]; DNA binding site 521095001039 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 521095001040 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521095001041 active site 521095001042 phosphorylation site [posttranslational modification] 521095001043 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 521095001044 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 521095001045 active site 521095001046 P-loop; other site 521095001047 phosphorylation site [posttranslational modification] 521095001048 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 521095001049 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 521095001050 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 521095001051 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 521095001052 intersubunit interface [polypeptide binding]; other site 521095001053 active site 521095001054 Zn2+ binding site [ion binding]; other site 521095001055 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 521095001056 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 521095001057 AP (apurinic/apyrimidinic) site pocket; other site 521095001058 DNA interaction; other site 521095001059 Metal-binding active site; metal-binding site 521095001060 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 521095001061 active site 521095001062 intersubunit interactions; other site 521095001063 catalytic residue [active] 521095001064 transketolase; Reviewed; Region: PRK05899 521095001065 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 521095001066 TPP-binding site [chemical binding]; other site 521095001067 dimer interface [polypeptide binding]; other site 521095001068 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 521095001069 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 521095001070 PYR/PP interface [polypeptide binding]; other site 521095001071 dimer interface [polypeptide binding]; other site 521095001072 TPP binding site [chemical binding]; other site 521095001073 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 521095001074 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521095001075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095001076 non-specific DNA binding site [nucleotide binding]; other site 521095001077 salt bridge; other site 521095001078 sequence-specific DNA binding site [nucleotide binding]; other site 521095001079 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095001080 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095001081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095001082 Walker A/P-loop; other site 521095001083 ATP binding site [chemical binding]; other site 521095001084 Q-loop/lid; other site 521095001085 ABC transporter signature motif; other site 521095001086 Walker B; other site 521095001087 D-loop; other site 521095001088 H-loop/switch region; other site 521095001089 putative oxidoreductase; Provisional; Region: PRK12831 521095001090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521095001091 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 521095001092 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 521095001093 FAD binding pocket [chemical binding]; other site 521095001094 FAD binding motif [chemical binding]; other site 521095001095 phosphate binding motif [ion binding]; other site 521095001096 beta-alpha-beta structure motif; other site 521095001097 NAD binding pocket [chemical binding]; other site 521095001098 Iron coordination center [ion binding]; other site 521095001099 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 521095001100 putative active site [active] 521095001101 catalytic residue [active] 521095001102 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 521095001103 putative substrate binding pocket [chemical binding]; other site 521095001104 AC domain interface; other site 521095001105 catalytic triad [active] 521095001106 AB domain interface; other site 521095001107 interchain disulfide; other site 521095001108 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 521095001109 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 521095001110 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095001111 active site 521095001112 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 521095001113 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 521095001114 Substrate binding site; other site 521095001115 Mg++ binding site; other site 521095001116 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 521095001117 active site 521095001118 substrate binding site [chemical binding]; other site 521095001119 CoA binding site [chemical binding]; other site 521095001120 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 521095001121 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 521095001122 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 521095001123 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 521095001124 substrate binding pocket [chemical binding]; other site 521095001125 chain length determination region; other site 521095001126 substrate-Mg2+ binding site; other site 521095001127 catalytic residues [active] 521095001128 aspartate-rich region 1; other site 521095001129 active site lid residues [active] 521095001130 aspartate-rich region 2; other site 521095001131 UDP-glucose 4-epimerase; Region: PLN02240 521095001132 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 521095001133 NAD binding site [chemical binding]; other site 521095001134 homodimer interface [polypeptide binding]; other site 521095001135 active site 521095001136 substrate binding site [chemical binding]; other site 521095001137 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 521095001138 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095001139 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521095001140 Walker A/P-loop; other site 521095001141 ATP binding site [chemical binding]; other site 521095001142 Q-loop/lid; other site 521095001143 ABC transporter signature motif; other site 521095001144 Walker B; other site 521095001145 D-loop; other site 521095001146 H-loop/switch region; other site 521095001147 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521095001148 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521095001149 FtsX-like permease family; Region: FtsX; pfam02687 521095001150 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 521095001151 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 521095001152 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 521095001153 dimerization interface [polypeptide binding]; other site 521095001154 ATP binding site [chemical binding]; other site 521095001155 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 521095001156 dimerization interface [polypeptide binding]; other site 521095001157 ATP binding site [chemical binding]; other site 521095001158 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 521095001159 putative active site [active] 521095001160 catalytic triad [active] 521095001161 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 521095001162 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095001163 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521095001164 Walker A/P-loop; other site 521095001165 ATP binding site [chemical binding]; other site 521095001166 Q-loop/lid; other site 521095001167 ABC transporter signature motif; other site 521095001168 Walker B; other site 521095001169 D-loop; other site 521095001170 H-loop/switch region; other site 521095001171 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095001172 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521095001173 Walker A/P-loop; other site 521095001174 ATP binding site [chemical binding]; other site 521095001175 Q-loop/lid; other site 521095001176 ABC transporter signature motif; other site 521095001177 Walker B; other site 521095001178 D-loop; other site 521095001179 H-loop/switch region; other site 521095001180 Predicted membrane protein [Function unknown]; Region: COG3601 521095001181 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 521095001182 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 521095001183 FAD binding domain; Region: FAD_binding_4; pfam01565 521095001184 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 521095001185 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 521095001186 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 521095001187 active site 521095001188 ADP/pyrophosphate binding site [chemical binding]; other site 521095001189 dimerization interface [polypeptide binding]; other site 521095001190 allosteric effector site; other site 521095001191 fructose-1,6-bisphosphate binding site; other site 521095001192 6-phosphofructokinase; Provisional; Region: PRK14072 521095001193 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 521095001194 active site 521095001195 ADP/pyrophosphate binding site [chemical binding]; other site 521095001196 dimerization interface [polypeptide binding]; other site 521095001197 allosteric effector site; other site 521095001198 fructose-1,6-bisphosphate binding site; other site 521095001199 enolase; Provisional; Region: eno; PRK00077 521095001200 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 521095001201 dimer interface [polypeptide binding]; other site 521095001202 metal binding site [ion binding]; metal-binding site 521095001203 substrate binding pocket [chemical binding]; other site 521095001204 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 521095001205 Part of AAA domain; Region: AAA_19; pfam13245 521095001206 Family description; Region: UvrD_C_2; pfam13538 521095001207 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 521095001208 G1 box; other site 521095001209 GTP/Mg2+ binding site [chemical binding]; other site 521095001210 Switch I region; other site 521095001211 G2 box; other site 521095001212 G3 box; other site 521095001213 Switch II region; other site 521095001214 G4 box; other site 521095001215 G5 box; other site 521095001216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095001217 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095001218 Walker A/P-loop; other site 521095001219 ATP binding site [chemical binding]; other site 521095001220 Q-loop/lid; other site 521095001221 ABC transporter signature motif; other site 521095001222 Walker B; other site 521095001223 D-loop; other site 521095001224 H-loop/switch region; other site 521095001225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521095001226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521095001227 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 521095001228 dimerization interface [polypeptide binding]; other site 521095001229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095001230 active site 521095001231 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 521095001232 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 521095001233 putative dimer interface [polypeptide binding]; other site 521095001234 putative anticodon binding site; other site 521095001235 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 521095001236 homodimer interface [polypeptide binding]; other site 521095001237 motif 1; other site 521095001238 motif 2; other site 521095001239 active site 521095001240 motif 3; other site 521095001241 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521095001242 catalytic core [active] 521095001243 CHAD domain; Region: CHAD; pfam05235 521095001244 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 521095001245 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 521095001246 homodimer interface [polypeptide binding]; other site 521095001247 substrate-cofactor binding pocket; other site 521095001248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095001249 catalytic residue [active] 521095001250 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 521095001251 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 521095001252 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 521095001253 dipeptidase PepV; Reviewed; Region: PRK07318 521095001254 active site 521095001255 metal binding site [ion binding]; metal-binding site 521095001256 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095001257 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521095001258 Walker A/P-loop; other site 521095001259 ATP binding site [chemical binding]; other site 521095001260 Q-loop/lid; other site 521095001261 ABC transporter signature motif; other site 521095001262 Walker B; other site 521095001263 D-loop; other site 521095001264 H-loop/switch region; other site 521095001265 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 521095001266 FtsX-like permease family; Region: FtsX; pfam02687 521095001267 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 521095001268 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 521095001269 Peptidase M16C associated; Region: M16C_assoc; pfam08367 521095001270 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 521095001271 EamA-like transporter family; Region: EamA; pfam00892 521095001272 EamA-like transporter family; Region: EamA; pfam00892 521095001273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 521095001274 SlyX; Region: SlyX; cl01090 521095001275 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 521095001276 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 521095001277 Family description; Region: UvrD_C_2; pfam13538 521095001278 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 521095001279 Mechanosensitive ion channel; Region: MS_channel; pfam00924 521095001280 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 521095001281 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 521095001282 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 521095001283 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 521095001284 Asp23 family; Region: Asp23; pfam03780 521095001285 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 521095001286 active site 521095001287 substrate binding site [chemical binding]; other site 521095001288 Phosphotransferase enzyme family; Region: APH; pfam01636 521095001289 ATP binding site [chemical binding]; other site 521095001290 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 521095001291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001292 dimer interface [polypeptide binding]; other site 521095001293 conserved gate region; other site 521095001294 putative PBP binding loops; other site 521095001295 ABC-ATPase subunit interface; other site 521095001296 NMT1/THI5 like; Region: NMT1; pfam09084 521095001297 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095001298 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 521095001299 Walker A/P-loop; other site 521095001300 ATP binding site [chemical binding]; other site 521095001301 Q-loop/lid; other site 521095001302 ABC transporter signature motif; other site 521095001303 Walker B; other site 521095001304 D-loop; other site 521095001305 H-loop/switch region; other site 521095001306 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 521095001307 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 521095001308 oligomer interface [polypeptide binding]; other site 521095001309 putative active site [active] 521095001310 metal binding site [ion binding]; metal-binding site 521095001311 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 521095001312 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 521095001313 intersubunit interface [polypeptide binding]; other site 521095001314 active site 521095001315 zinc binding site [ion binding]; other site 521095001316 Na+ binding site [ion binding]; other site 521095001317 Transcriptional regulator; Region: Rrf2; cl17282 521095001318 Rrf2 family protein; Region: rrf2_super; TIGR00738 521095001319 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 521095001320 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 521095001321 trimerization site [polypeptide binding]; other site 521095001322 active site 521095001323 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 521095001324 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 521095001325 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521095001326 catalytic residue [active] 521095001327 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 521095001328 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 521095001329 FeS assembly protein SufB; Region: sufB; TIGR01980 521095001330 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 521095001331 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 521095001332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095001333 Walker A/P-loop; other site 521095001334 ATP binding site [chemical binding]; other site 521095001335 Q-loop/lid; other site 521095001336 ABC transporter signature motif; other site 521095001337 Walker B; other site 521095001338 D-loop; other site 521095001339 H-loop/switch region; other site 521095001340 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 521095001341 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 521095001342 dimer interface [polypeptide binding]; other site 521095001343 motif 1; other site 521095001344 active site 521095001345 motif 2; other site 521095001346 motif 3; other site 521095001347 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 521095001348 anticodon binding site; other site 521095001349 Helix-turn-helix domain; Region: HTH_28; pfam13518 521095001350 HTH-like domain; Region: HTH_21; pfam13276 521095001351 Integrase core domain; Region: rve; pfam00665 521095001352 Integrase core domain; Region: rve_2; pfam13333 521095001353 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 521095001354 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521095001355 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 521095001356 Walker A/P-loop; other site 521095001357 ATP binding site [chemical binding]; other site 521095001358 Q-loop/lid; other site 521095001359 ABC transporter signature motif; other site 521095001360 Walker B; other site 521095001361 D-loop; other site 521095001362 H-loop/switch region; other site 521095001363 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 521095001364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521095001365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521095001366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 521095001367 dimerization interface [polypeptide binding]; other site 521095001368 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521095001369 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521095001370 active site 521095001371 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 521095001372 4Fe-4S binding domain; Region: Fer4_6; pfam12837 521095001373 4Fe-4S binding domain; Region: Fer4; pfam00037 521095001374 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 521095001375 Glucan-binding protein C; Region: GbpC; pfam08363 521095001376 phosphoglycolate phosphatase; Provisional; Region: PRK13222 521095001377 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521095001378 motif II; other site 521095001379 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521095001380 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521095001381 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 521095001382 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 521095001383 active site 521095001384 ATP binding site [chemical binding]; other site 521095001385 substrate binding site [chemical binding]; other site 521095001386 activation loop (A-loop); other site 521095001387 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521095001388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095001389 Walker A/P-loop; other site 521095001390 ATP binding site [chemical binding]; other site 521095001391 Q-loop/lid; other site 521095001392 ABC transporter signature motif; other site 521095001393 Walker B; other site 521095001394 D-loop; other site 521095001395 H-loop/switch region; other site 521095001396 ABC-2 type transporter; Region: ABC2_membrane; cl17235 521095001397 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 521095001398 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 521095001399 dimer interface [polypeptide binding]; other site 521095001400 anticodon binding site; other site 521095001401 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521095001402 motif 1; other site 521095001403 dimer interface [polypeptide binding]; other site 521095001404 active site 521095001405 motif 2; other site 521095001406 GAD domain; Region: GAD; pfam02938 521095001407 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521095001408 active site 521095001409 motif 3; other site 521095001410 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095001411 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095001412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095001413 Walker A/P-loop; other site 521095001414 ATP binding site [chemical binding]; other site 521095001415 Q-loop/lid; other site 521095001416 ABC transporter signature motif; other site 521095001417 Walker B; other site 521095001418 D-loop; other site 521095001419 H-loop/switch region; other site 521095001420 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095001421 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095001422 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 521095001423 Walker A/P-loop; other site 521095001424 ATP binding site [chemical binding]; other site 521095001425 Q-loop/lid; other site 521095001426 ABC transporter signature motif; other site 521095001427 Walker B; other site 521095001428 D-loop; other site 521095001429 H-loop/switch region; other site 521095001430 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 521095001431 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521095001432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521095001433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 521095001434 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 521095001435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521095001436 putative substrate translocation pore; other site 521095001437 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521095001438 catalytic core [active] 521095001439 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521095001440 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 521095001441 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 521095001442 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 521095001443 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 521095001444 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 521095001445 substrate binding pocket [chemical binding]; other site 521095001446 membrane-bound complex binding site; other site 521095001447 hinge residues; other site 521095001448 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 521095001449 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 521095001450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001451 dimer interface [polypeptide binding]; other site 521095001452 conserved gate region; other site 521095001453 putative PBP binding loops; other site 521095001454 ABC-ATPase subunit interface; other site 521095001455 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 521095001456 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 521095001457 Walker A/P-loop; other site 521095001458 ATP binding site [chemical binding]; other site 521095001459 Q-loop/lid; other site 521095001460 ABC transporter signature motif; other site 521095001461 Walker B; other site 521095001462 D-loop; other site 521095001463 H-loop/switch region; other site 521095001464 two-component response regulator VirG; Provisional; Region: PRK13856 521095001465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095001466 DNA binding site [nucleotide binding] 521095001467 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 521095001468 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 521095001469 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521095001470 protein binding site [polypeptide binding]; other site 521095001471 RmuC family; Region: RmuC; pfam02646 521095001472 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 521095001473 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 521095001474 Walker A/P-loop; other site 521095001475 ATP binding site [chemical binding]; other site 521095001476 Q-loop/lid; other site 521095001477 ABC transporter signature motif; other site 521095001478 Walker B; other site 521095001479 D-loop; other site 521095001480 H-loop/switch region; other site 521095001481 C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156 521095001482 putative homodimer interface [polypeptide binding]; other site 521095001483 putative homotetramer interface [polypeptide binding]; other site 521095001484 putative allosteric switch controlling residues; other site 521095001485 putative metal binding site [ion binding]; other site 521095001486 putative homodimer-homodimer interface [polypeptide binding]; other site 521095001487 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 521095001488 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521095001489 metal-binding site [ion binding] 521095001490 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095001491 Soluble P-type ATPase [General function prediction only]; Region: COG4087 521095001492 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521095001493 metal-binding site [ion binding] 521095001494 adenosine deaminase; Provisional; Region: PRK09358 521095001495 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 521095001496 active site 521095001497 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 521095001498 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 521095001499 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 521095001500 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521095001501 active site 521095001502 metal binding site [ion binding]; metal-binding site 521095001503 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 521095001504 putative active site [active] 521095001505 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 521095001506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001507 dimer interface [polypeptide binding]; other site 521095001508 conserved gate region; other site 521095001509 putative PBP binding loops; other site 521095001510 ABC-ATPase subunit interface; other site 521095001511 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 521095001512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001513 dimer interface [polypeptide binding]; other site 521095001514 conserved gate region; other site 521095001515 putative PBP binding loops; other site 521095001516 ABC-ATPase subunit interface; other site 521095001517 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 521095001518 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 521095001519 Walker A/P-loop; other site 521095001520 ATP binding site [chemical binding]; other site 521095001521 Q-loop/lid; other site 521095001522 ABC transporter signature motif; other site 521095001523 Walker B; other site 521095001524 D-loop; other site 521095001525 H-loop/switch region; other site 521095001526 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 521095001527 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 521095001528 substrate binding pocket [chemical binding]; other site 521095001529 membrane-bound complex binding site; other site 521095001530 hinge residues; other site 521095001531 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 521095001532 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 521095001533 active site 521095001534 catalytic triad [active] 521095001535 oxyanion hole [active] 521095001536 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 521095001537 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 521095001538 recombination factor protein RarA; Reviewed; Region: PRK13342 521095001539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095001540 Walker A motif; other site 521095001541 ATP binding site [chemical binding]; other site 521095001542 Walker B motif; other site 521095001543 arginine finger; other site 521095001544 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 521095001545 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 521095001546 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 521095001547 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 521095001548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521095001549 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521095001550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521095001551 DNA binding residues [nucleotide binding] 521095001552 Domain of unknown function DUF20; Region: UPF0118; pfam01594 521095001553 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 521095001554 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 521095001555 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 521095001556 motif 1; other site 521095001557 active site 521095001558 motif 2; other site 521095001559 motif 3; other site 521095001560 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 521095001561 DHHA1 domain; Region: DHHA1; pfam02272 521095001562 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 521095001563 YceG-like family; Region: YceG; pfam02618 521095001564 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 521095001565 dimerization interface [polypeptide binding]; other site 521095001566 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 521095001567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521095001568 active site 521095001569 motif I; other site 521095001570 motif II; other site 521095001571 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 521095001572 Shikimate kinase; Region: SKI; pfam01202 521095001573 ADP binding site [chemical binding]; other site 521095001574 magnesium binding site [ion binding]; other site 521095001575 putative shikimate binding site; other site 521095001576 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 521095001577 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 521095001578 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 521095001579 active site 521095001580 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 521095001581 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 521095001582 active pocket/dimerization site; other site 521095001583 active site 521095001584 phosphorylation site [posttranslational modification] 521095001585 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 521095001586 active site 521095001587 phosphorylation site [posttranslational modification] 521095001588 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 521095001589 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 521095001590 Domain of unknown function (DUF956); Region: DUF956; pfam06115 521095001591 elongation factor P; Validated; Region: PRK00529 521095001592 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 521095001593 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 521095001594 RNA binding site [nucleotide binding]; other site 521095001595 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 521095001596 RNA binding site [nucleotide binding]; other site 521095001597 Asp23 family; Region: Asp23; pfam03780 521095001598 transcription antitermination factor NusB; Region: nusB; TIGR01951 521095001599 putative RNA binding site [nucleotide binding]; other site 521095001600 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 521095001601 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 521095001602 S4 RNA-binding domain; Region: S4; smart00363 521095001603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095001604 S-adenosylmethionine binding site [chemical binding]; other site 521095001605 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 521095001606 ATP-NAD kinase; Region: NAD_kinase; pfam01513 521095001607 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 521095001608 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 521095001609 Walker A/P-loop; other site 521095001610 ATP binding site [chemical binding]; other site 521095001611 Q-loop/lid; other site 521095001612 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 521095001613 ABC transporter signature motif; other site 521095001614 Walker B; other site 521095001615 D-loop; other site 521095001616 H-loop/switch region; other site 521095001617 CTP synthetase; Validated; Region: pyrG; PRK05380 521095001618 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 521095001619 Catalytic site [active] 521095001620 active site 521095001621 UTP binding site [chemical binding]; other site 521095001622 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 521095001623 active site 521095001624 putative oxyanion hole; other site 521095001625 catalytic triad [active] 521095001626 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 521095001627 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 521095001628 active site 521095001629 Int/Topo IB signature motif; other site 521095001630 cell division protein MraZ; Reviewed; Region: PRK00326 521095001631 MraZ protein; Region: MraZ; pfam02381 521095001632 MraZ protein; Region: MraZ; pfam02381 521095001633 MraW methylase family; Region: Methyltransf_5; cl17771 521095001634 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 521095001635 Cell division protein FtsL; Region: FtsL; cl11433 521095001636 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 521095001637 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521095001638 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521095001639 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 521095001640 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521095001641 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521095001642 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 521095001643 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 521095001644 Mg++ binding site [ion binding]; other site 521095001645 putative catalytic motif [active] 521095001646 putative substrate binding site [chemical binding]; other site 521095001647 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 521095001648 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521095001649 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521095001650 cell division protein FtsW; Region: ftsW; TIGR02614 521095001651 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 521095001652 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 521095001653 active site 521095001654 homodimer interface [polypeptide binding]; other site 521095001655 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 521095001656 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521095001657 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521095001658 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521095001659 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 521095001660 FAD binding domain; Region: FAD_binding_4; pfam01565 521095001661 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 521095001662 cell division protein FtsQ; Provisional; Region: PRK05529 521095001663 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 521095001664 Cell division protein FtsQ; Region: FtsQ; pfam03799 521095001665 cell division protein FtsZ; Validated; Region: PRK09330 521095001666 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 521095001667 nucleotide binding site [chemical binding]; other site 521095001668 SulA interaction site; other site 521095001669 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 521095001670 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 521095001671 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 521095001672 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521095001673 catalytic residue [active] 521095001674 Protein of unknown function (DUF552); Region: DUF552; pfam04472 521095001675 YGGT family; Region: YGGT; pfam02325 521095001676 DivIVA protein; Region: DivIVA; pfam05103 521095001677 DivIVA domain; Region: DivI1A_domain; TIGR03544 521095001678 Domain of unknown function (DUF4130; Region: DUF4130; pfam13566 521095001679 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 521095001680 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095001681 FeS/SAM binding site; other site 521095001682 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 521095001683 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 521095001684 active site 521095001685 NTP binding site [chemical binding]; other site 521095001686 metal binding triad [ion binding]; metal-binding site 521095001687 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 521095001688 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521095001689 Zn2+ binding site [ion binding]; other site 521095001690 Mg2+ binding site [ion binding]; other site 521095001691 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 521095001692 Predicted membrane protein [Function unknown]; Region: COG1511 521095001693 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 521095001694 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 521095001695 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 521095001696 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 521095001697 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 521095001698 Predicted membrane protein [Function unknown]; Region: COG1511 521095001699 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 521095001700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 521095001701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 521095001702 S-adenosylmethionine synthetase; Validated; Region: PRK05250 521095001703 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 521095001704 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 521095001705 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 521095001706 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 521095001707 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 521095001708 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 521095001709 putative L-serine binding site [chemical binding]; other site 521095001710 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 521095001711 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 521095001712 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 521095001713 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521095001714 HIGH motif; other site 521095001715 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 521095001716 active site 521095001717 KMSKS motif; other site 521095001718 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 521095001719 active site 521095001720 catalytic site [active] 521095001721 substrate binding site [chemical binding]; other site 521095001722 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 521095001723 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 521095001724 active site 521095001725 metal binding site [ion binding]; metal-binding site 521095001726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521095001727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095001728 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 521095001729 Walker A/P-loop; other site 521095001730 ATP binding site [chemical binding]; other site 521095001731 ABC transporter signature motif; other site 521095001732 Walker B; other site 521095001733 D-loop; other site 521095001734 H-loop/switch region; other site 521095001735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 521095001736 putative substrate translocation pore; other site 521095001737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 521095001738 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 521095001739 Uncharacterized conserved protein [Function unknown]; Region: COG2461 521095001740 Family of unknown function (DUF438); Region: DUF438; pfam04282 521095001741 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 521095001742 RelB antitoxin; Region: RelB; cl01171 521095001743 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 521095001744 putative catalytic site [active] 521095001745 putative metal binding site [ion binding]; other site 521095001746 putative phosphate binding site [ion binding]; other site 521095001747 aspartate aminotransferase; Provisional; Region: PRK05764 521095001748 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521095001749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095001750 homodimer interface [polypeptide binding]; other site 521095001751 catalytic residue [active] 521095001752 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 521095001753 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 521095001754 active site 521095001755 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521095001756 substrate binding site [chemical binding]; other site 521095001757 catalytic residues [active] 521095001758 dimer interface [polypeptide binding]; other site 521095001759 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 521095001760 dihydrodipicolinate synthase; Region: dapA; TIGR00674 521095001761 dimer interface [polypeptide binding]; other site 521095001762 active site 521095001763 catalytic residue [active] 521095001764 dihydrodipicolinate reductase; Provisional; Region: PRK00048 521095001765 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 521095001766 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 521095001767 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 521095001768 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 521095001769 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 521095001770 active site 521095001771 trimer interface [polypeptide binding]; other site 521095001772 substrate binding site [chemical binding]; other site 521095001773 CoA binding site [chemical binding]; other site 521095001774 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 521095001775 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 521095001776 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 521095001777 DHH family; Region: DHH; pfam01368 521095001778 DEAD-like helicases superfamily; Region: DEXDc; smart00487 521095001779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521095001780 ATP binding site [chemical binding]; other site 521095001781 putative Mg++ binding site [ion binding]; other site 521095001782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095001783 nucleotide binding region [chemical binding]; other site 521095001784 ATP-binding site [chemical binding]; other site 521095001785 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 521095001786 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521095001787 Zn2+ binding site [ion binding]; other site 521095001788 Mg2+ binding site [ion binding]; other site 521095001789 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 521095001790 synthetase active site [active] 521095001791 NTP binding site [chemical binding]; other site 521095001792 metal binding site [ion binding]; metal-binding site 521095001793 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 521095001794 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 521095001795 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 521095001796 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 521095001797 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 521095001798 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 521095001799 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 521095001800 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 521095001801 23S rRNA binding site [nucleotide binding]; other site 521095001802 L21 binding site [polypeptide binding]; other site 521095001803 L13 binding site [polypeptide binding]; other site 521095001804 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 521095001805 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 521095001806 Mg++ binding site [ion binding]; other site 521095001807 putative catalytic motif [active] 521095001808 substrate binding site [chemical binding]; other site 521095001809 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 521095001810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095001811 FeS/SAM binding site; other site 521095001812 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 521095001813 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 521095001814 active site 521095001815 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 521095001816 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 521095001817 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095001818 active site 521095001819 HIGH motif; other site 521095001820 nucleotide binding site [chemical binding]; other site 521095001821 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 521095001822 KMSK motif region; other site 521095001823 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 521095001824 tRNA binding surface [nucleotide binding]; other site 521095001825 anticodon binding site; other site 521095001826 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 521095001827 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 521095001828 transcription termination factor Rho; Provisional; Region: rho; PRK09376 521095001829 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 521095001830 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521095001831 RNA binding site [nucleotide binding]; other site 521095001832 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 521095001833 Walker A motif; other site 521095001834 ATP binding site [chemical binding]; other site 521095001835 Walker B motif; other site 521095001836 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 521095001837 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 521095001838 putative ligand binding site [chemical binding]; other site 521095001839 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521095001840 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 521095001841 TM-ABC transporter signature motif; other site 521095001842 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 521095001843 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 521095001844 TM-ABC transporter signature motif; other site 521095001845 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 521095001846 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 521095001847 Walker A/P-loop; other site 521095001848 ATP binding site [chemical binding]; other site 521095001849 Q-loop/lid; other site 521095001850 ABC transporter signature motif; other site 521095001851 Walker B; other site 521095001852 D-loop; other site 521095001853 H-loop/switch region; other site 521095001854 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 521095001855 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 521095001856 Walker A/P-loop; other site 521095001857 ATP binding site [chemical binding]; other site 521095001858 Q-loop/lid; other site 521095001859 ABC transporter signature motif; other site 521095001860 Walker B; other site 521095001861 D-loop; other site 521095001862 H-loop/switch region; other site 521095001863 homoserine kinase; Provisional; Region: PRK01212 521095001864 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 521095001865 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 521095001866 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 521095001867 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 521095001868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095001869 catalytic residue [active] 521095001870 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 521095001871 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 521095001872 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 521095001873 aspartate kinase; Reviewed; Region: PRK09034 521095001874 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 521095001875 nucleotide binding site [chemical binding]; other site 521095001876 substrate binding site [chemical binding]; other site 521095001877 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521095001878 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 521095001879 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 521095001880 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 521095001881 SnoaL-like domain; Region: SnoaL_2; pfam12680 521095001882 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 521095001883 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 521095001884 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 521095001885 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521095001886 active site 521095001887 Int/Topo IB signature motif; other site 521095001888 DNA binding site [nucleotide binding] 521095001889 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521095001890 active site 521095001891 catalytic site [active] 521095001892 substrate binding site [chemical binding]; other site 521095001893 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 521095001894 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 521095001895 Dimer interface [polypeptide binding]; other site 521095001896 BRCT sequence motif; other site 521095001897 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521095001898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095001899 non-specific DNA binding site [nucleotide binding]; other site 521095001900 salt bridge; other site 521095001901 sequence-specific DNA binding site [nucleotide binding]; other site 521095001902 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 521095001903 Catalytic site [active] 521095001904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095001905 non-specific DNA binding site [nucleotide binding]; other site 521095001906 salt bridge; other site 521095001907 sequence-specific DNA binding site [nucleotide binding]; other site 521095001908 Prophage antirepressor [Transcription]; Region: COG3617 521095001909 BRO family, N-terminal domain; Region: Bro-N; smart01040 521095001910 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 521095001911 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095001912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095001913 S-adenosylmethionine binding site [chemical binding]; other site 521095001914 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 521095001915 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 521095001916 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 521095001917 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521095001918 active site 521095001919 DNA binding site [nucleotide binding] 521095001920 Int/Topo IB signature motif; other site 521095001921 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 521095001922 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 521095001923 dimer interface [polypeptide binding]; other site 521095001924 ssDNA binding site [nucleotide binding]; other site 521095001925 tetramer (dimer of dimers) interface [polypeptide binding]; other site 521095001926 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 521095001927 AAA domain; Region: AAA_22; pfam13401 521095001928 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 521095001929 Phage capsid family; Region: Phage_capsid; pfam05065 521095001930 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 521095001931 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 521095001932 tape measure domain; Region: tape_meas_nterm; TIGR02675 521095001933 Phage-related protein [Function unknown]; Region: COG5412 521095001934 Bacteriophage holin; Region: Phage_holin_1; pfam04531 521095001935 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 521095001936 amidase catalytic site [active] 521095001937 Zn binding residues [ion binding]; other site 521095001938 substrate binding site [chemical binding]; other site 521095001939 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 521095001940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095001941 non-specific DNA binding site [nucleotide binding]; other site 521095001942 salt bridge; other site 521095001943 sequence-specific DNA binding site [nucleotide binding]; other site 521095001944 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 521095001945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521095001946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095001947 homodimer interface [polypeptide binding]; other site 521095001948 catalytic residue [active] 521095001949 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 521095001950 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 521095001951 putative substrate binding site [chemical binding]; other site 521095001952 putative ATP binding site [chemical binding]; other site 521095001953 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 521095001954 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 521095001955 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 521095001956 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 521095001957 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 521095001958 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 521095001959 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 521095001960 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 521095001961 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 521095001962 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 521095001963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095001964 DNA-binding site [nucleotide binding]; DNA binding site 521095001965 UTRA domain; Region: UTRA; pfam07702 521095001966 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 521095001967 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 521095001968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001969 dimer interface [polypeptide binding]; other site 521095001970 conserved gate region; other site 521095001971 putative PBP binding loops; other site 521095001972 ABC-ATPase subunit interface; other site 521095001973 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 521095001974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095001975 dimer interface [polypeptide binding]; other site 521095001976 conserved gate region; other site 521095001977 putative PBP binding loops; other site 521095001978 ABC-ATPase subunit interface; other site 521095001979 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 521095001980 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 521095001981 Walker A/P-loop; other site 521095001982 ATP binding site [chemical binding]; other site 521095001983 Q-loop/lid; other site 521095001984 ABC transporter signature motif; other site 521095001985 Walker B; other site 521095001986 D-loop; other site 521095001987 H-loop/switch region; other site 521095001988 TOBE domain; Region: TOBE_2; pfam08402 521095001989 4-alpha-glucanotransferase; Provisional; Region: PRK14508 521095001990 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 521095001991 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 521095001992 glutamate dehydrogenase; Provisional; Region: PRK09414 521095001993 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 521095001994 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 521095001995 NAD(P) binding site [chemical binding]; other site 521095001996 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 521095001997 active site 521095001998 DNA binding site [nucleotide binding] 521095001999 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 521095002000 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 521095002001 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 521095002002 catalytic site [active] 521095002003 subunit interface [polypeptide binding]; other site 521095002004 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 521095002005 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521095002006 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 521095002007 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 521095002008 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 521095002009 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521095002010 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 521095002011 IMP binding site; other site 521095002012 dimer interface [polypeptide binding]; other site 521095002013 partial ornithine binding site; other site 521095002014 trigger factor; Region: tig; TIGR00115 521095002015 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 521095002016 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 521095002017 Clp protease; Region: CLP_protease; pfam00574 521095002018 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 521095002019 oligomer interface [polypeptide binding]; other site 521095002020 active site residues [active] 521095002021 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 521095002022 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 521095002023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095002024 Walker A motif; other site 521095002025 ATP binding site [chemical binding]; other site 521095002026 Walker B motif; other site 521095002027 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 521095002028 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 521095002029 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 521095002030 Ligand binding site; other site 521095002031 metal-binding site 521095002032 TatD related DNase; Region: TatD_DNase; pfam01026 521095002033 active site 521095002034 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 521095002035 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 521095002036 putative ATP binding site [chemical binding]; other site 521095002037 putative substrate interface [chemical binding]; other site 521095002038 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 521095002039 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095002040 active site 521095002041 HIGH motif; other site 521095002042 nucleotide binding site [chemical binding]; other site 521095002043 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521095002044 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 521095002045 active site 521095002046 KMSKS motif; other site 521095002047 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 521095002048 tRNA binding surface [nucleotide binding]; other site 521095002049 anticodon binding site; other site 521095002050 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 521095002051 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 521095002052 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 521095002053 Potassium binding sites [ion binding]; other site 521095002054 Cesium cation binding sites [ion binding]; other site 521095002055 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 521095002056 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 521095002057 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 521095002058 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 521095002059 homodimer interface [polypeptide binding]; other site 521095002060 NADP binding site [chemical binding]; other site 521095002061 substrate binding site [chemical binding]; other site 521095002062 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 521095002063 homodecamer interface [polypeptide binding]; other site 521095002064 GTP cyclohydrolase I; Provisional; Region: PLN03044 521095002065 active site 521095002066 putative catalytic site residues [active] 521095002067 zinc binding site [ion binding]; other site 521095002068 GTP-CH-I/GFRP interaction surface; other site 521095002069 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 521095002070 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521095002071 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521095002072 Double zinc ribbon; Region: DZR; pfam12773 521095002073 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 521095002074 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 521095002075 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 521095002076 active site 521095002077 dimer interface [polypeptide binding]; other site 521095002078 motif 1; other site 521095002079 motif 2; other site 521095002080 motif 3; other site 521095002081 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 521095002082 anticodon binding site; other site 521095002083 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 521095002084 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 521095002085 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 521095002086 putative catalytic cysteine [active] 521095002087 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 521095002088 putative active site [active] 521095002089 metal binding site [ion binding]; metal-binding site 521095002090 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 521095002091 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 521095002092 folate binding site [chemical binding]; other site 521095002093 NADP+ binding site [chemical binding]; other site 521095002094 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 521095002095 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 521095002096 dimerization interface [polypeptide binding]; other site 521095002097 active site 521095002098 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 521095002099 active site 521095002100 8-oxo-dGMP binding site [chemical binding]; other site 521095002101 nudix motif; other site 521095002102 metal binding site [ion binding]; metal-binding site 521095002103 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 521095002104 active site 521095002105 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 521095002106 active site 2 [active] 521095002107 active site 1 [active] 521095002108 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 521095002109 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521095002110 Zn2+ binding site [ion binding]; other site 521095002111 Mg2+ binding site [ion binding]; other site 521095002112 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 521095002113 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 521095002114 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 521095002115 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 521095002116 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 521095002117 catalytic site [active] 521095002118 putative active site [active] 521095002119 putative substrate binding site [chemical binding]; other site 521095002120 HRDC domain; Region: HRDC; pfam00570 521095002121 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 521095002122 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 521095002123 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 521095002124 generic binding surface I; other site 521095002125 generic binding surface II; other site 521095002126 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 521095002127 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 521095002128 nucleotide binding site/active site [active] 521095002129 HIT family signature motif; other site 521095002130 catalytic residue [active] 521095002131 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 521095002132 propionate/acetate kinase; Provisional; Region: PRK12379 521095002133 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 521095002134 active site 521095002135 catalytic residues [active] 521095002136 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 521095002137 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 521095002138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521095002139 UDP-galactopyranose mutase; Region: GLF; pfam03275 521095002140 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521095002141 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521095002142 active site 521095002143 Maf-like protein; Region: Maf; pfam02545 521095002144 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 521095002145 active site 521095002146 dimer interface [polypeptide binding]; other site 521095002147 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 521095002148 TRAM domain; Region: TRAM; pfam01938 521095002149 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 521095002150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095002151 S-adenosylmethionine binding site [chemical binding]; other site 521095002152 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 521095002153 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 521095002154 active site 521095002155 HIGH motif; other site 521095002156 dimer interface [polypeptide binding]; other site 521095002157 KMSKS motif; other site 521095002158 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 521095002159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095002160 FeS/SAM binding site; other site 521095002161 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 521095002162 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 521095002163 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 521095002164 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 521095002165 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 521095002166 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521095002167 active site turn [active] 521095002168 phosphorylation site [posttranslational modification] 521095002169 Dehydroquinase class II; Region: DHquinase_II; pfam01220 521095002170 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 521095002171 trimer interface [polypeptide binding]; other site 521095002172 active site 521095002173 dimer interface [polypeptide binding]; other site 521095002174 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 521095002175 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 521095002176 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 521095002177 shikimate binding site; other site 521095002178 NAD(P) binding site [chemical binding]; other site 521095002179 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 521095002180 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 521095002181 ADP binding site [chemical binding]; other site 521095002182 magnesium binding site [ion binding]; other site 521095002183 putative shikimate binding site; other site 521095002184 Chorismate mutase type II; Region: CM_2; smart00830 521095002185 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 521095002186 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 521095002187 Tetramer interface [polypeptide binding]; other site 521095002188 active site 521095002189 FMN-binding site [chemical binding]; other site 521095002190 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 521095002191 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 521095002192 hinge; other site 521095002193 active site 521095002194 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 521095002195 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 521095002196 active site 521095002197 intersubunit interface [polypeptide binding]; other site 521095002198 catalytic residue [active] 521095002199 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 521095002200 active site 521095002201 dimer interface [polypeptide binding]; other site 521095002202 metal binding site [ion binding]; metal-binding site 521095002203 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095002204 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 521095002205 Soluble P-type ATPase [General function prediction only]; Region: COG4087 521095002206 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 521095002207 Double zinc ribbon; Region: DZR; pfam12773 521095002208 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 521095002209 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 521095002210 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 521095002211 active site 521095002212 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521095002213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521095002214 binding surface 521095002215 TPR motif; other site 521095002216 TPR repeat; Region: TPR_11; pfam13414 521095002217 rod shape-determining protein MreB; Provisional; Region: PRK13927 521095002218 MreB and similar proteins; Region: MreB_like; cd10225 521095002219 nucleotide binding site [chemical binding]; other site 521095002220 Mg binding site [ion binding]; other site 521095002221 putative protofilament interaction site [polypeptide binding]; other site 521095002222 RodZ interaction site [polypeptide binding]; other site 521095002223 rod shape-determining protein MreC; Provisional; Region: PRK13922 521095002224 rod shape-determining protein MreC; Region: MreC; pfam04085 521095002225 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 521095002226 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 521095002227 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521095002228 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521095002229 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 521095002230 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 521095002231 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 521095002232 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 521095002233 B12 binding site [chemical binding]; other site 521095002234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095002235 FeS/SAM binding site; other site 521095002236 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 521095002237 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 521095002238 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 521095002239 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 521095002240 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 521095002241 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095002242 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521095002243 Walker A/P-loop; other site 521095002244 ATP binding site [chemical binding]; other site 521095002245 Q-loop/lid; other site 521095002246 ABC transporter signature motif; other site 521095002247 Walker B; other site 521095002248 D-loop; other site 521095002249 H-loop/switch region; other site 521095002250 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095002251 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521095002252 Walker A/P-loop; other site 521095002253 ATP binding site [chemical binding]; other site 521095002254 Q-loop/lid; other site 521095002255 ABC transporter signature motif; other site 521095002256 Walker B; other site 521095002257 D-loop; other site 521095002258 H-loop/switch region; other site 521095002259 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 521095002260 GTPase CgtA; Reviewed; Region: obgE; PRK12297 521095002261 GTP1/OBG; Region: GTP1_OBG; pfam01018 521095002262 Obg GTPase; Region: Obg; cd01898 521095002263 G1 box; other site 521095002264 GTP/Mg2+ binding site [chemical binding]; other site 521095002265 Switch I region; other site 521095002266 G2 box; other site 521095002267 G3 box; other site 521095002268 Switch II region; other site 521095002269 G4 box; other site 521095002270 G5 box; other site 521095002271 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 521095002272 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 521095002273 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 521095002274 active site 521095002275 (T/H)XGH motif; other site 521095002276 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521095002277 Zn2+ binding site [ion binding]; other site 521095002278 Mg2+ binding site [ion binding]; other site 521095002279 Oligomerisation domain; Region: Oligomerisation; pfam02410 521095002280 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 521095002281 active site 521095002282 DNA polymerase IV; Validated; Region: PRK02406 521095002283 DNA binding site [nucleotide binding] 521095002284 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 521095002285 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 521095002286 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 521095002287 G-X-X-G motif; other site 521095002288 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 521095002289 RimM N-terminal domain; Region: RimM; pfam01782 521095002290 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 521095002291 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 521095002292 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 521095002293 Catalytic site [active] 521095002294 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 521095002295 dimer interface [polypeptide binding]; other site 521095002296 motif 1; other site 521095002297 active site 521095002298 motif 2; other site 521095002299 motif 3; other site 521095002300 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 521095002301 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521095002302 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 521095002303 pyruvate phosphate dikinase; Provisional; Region: PRK09279 521095002304 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 521095002305 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 521095002306 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 521095002307 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 521095002308 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521095002309 Zn2+ binding site [ion binding]; other site 521095002310 Mg2+ binding site [ion binding]; other site 521095002311 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 521095002312 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 521095002313 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 521095002314 RNA/DNA hybrid binding site [nucleotide binding]; other site 521095002315 active site 521095002316 hypothetical protein; Reviewed; Region: PRK12497 521095002317 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 521095002318 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 521095002319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095002320 Walker A motif; other site 521095002321 ATP binding site [chemical binding]; other site 521095002322 Walker B motif; other site 521095002323 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 521095002324 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 521095002325 DNA protecting protein DprA; Region: dprA; TIGR00732 521095002326 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 521095002327 Glucose inhibited division protein A; Region: GIDA; pfam01134 521095002328 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 521095002329 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 521095002330 active site 521095002331 DNA binding site [nucleotide binding] 521095002332 Int/Topo IB signature motif; other site 521095002333 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 521095002334 rRNA interaction site [nucleotide binding]; other site 521095002335 S8 interaction site; other site 521095002336 putative laminin-1 binding site; other site 521095002337 elongation factor Ts; Provisional; Region: tsf; PRK09377 521095002338 UBA/TS-N domain; Region: UBA; pfam00627 521095002339 Elongation factor TS; Region: EF_TS; pfam00889 521095002340 Elongation factor TS; Region: EF_TS; pfam00889 521095002341 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 521095002342 putative nucleotide binding site [chemical binding]; other site 521095002343 uridine monophosphate binding site [chemical binding]; other site 521095002344 homohexameric interface [polypeptide binding]; other site 521095002345 ribosome recycling factor; Reviewed; Region: frr; PRK00083 521095002346 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 521095002347 hinge region; other site 521095002348 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 521095002349 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 521095002350 catalytic residue [active] 521095002351 putative FPP diphosphate binding site; other site 521095002352 putative FPP binding hydrophobic cleft; other site 521095002353 dimer interface [polypeptide binding]; other site 521095002354 putative IPP diphosphate binding site; other site 521095002355 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 521095002356 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 521095002357 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 521095002358 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 521095002359 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 521095002360 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 521095002361 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521095002362 RIP metalloprotease RseP; Region: TIGR00054 521095002363 active site 521095002364 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521095002365 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 521095002366 protein binding site [polypeptide binding]; other site 521095002367 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 521095002368 putative substrate binding region [chemical binding]; other site 521095002369 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 521095002370 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 521095002371 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 521095002372 prolyl-tRNA synthetase; Provisional; Region: PRK09194 521095002373 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 521095002374 dimer interface [polypeptide binding]; other site 521095002375 motif 1; other site 521095002376 active site 521095002377 motif 2; other site 521095002378 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 521095002379 putative deacylase active site [active] 521095002380 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 521095002381 active site 521095002382 motif 3; other site 521095002383 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 521095002384 anticodon binding site; other site 521095002385 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 521095002386 ZIP Zinc transporter; Region: Zip; pfam02535 521095002387 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 521095002388 active site 521095002389 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 521095002390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521095002391 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521095002392 ABC transporter; Region: ABC_tran_2; pfam12848 521095002393 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521095002394 Peptidase family M50; Region: Peptidase_M50; pfam02163 521095002395 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 521095002396 active site 521095002397 putative substrate binding region [chemical binding]; other site 521095002398 ScpA/B protein; Region: ScpA_ScpB; cl00598 521095002399 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 521095002400 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 521095002401 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521095002402 RNA binding surface [nucleotide binding]; other site 521095002403 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 521095002404 active site 521095002405 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 521095002406 catalytic core [active] 521095002407 cytidylate kinase; Provisional; Region: cmk; PRK00023 521095002408 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 521095002409 CMP-binding site; other site 521095002410 The sites determining sugar specificity; other site 521095002411 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 521095002412 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 521095002413 putative acyl-acceptor binding pocket; other site 521095002414 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 521095002415 LytB protein; Region: LYTB; cl00507 521095002416 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 521095002417 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 521095002418 Protein of unknown function (DUF512); Region: DUF512; pfam04459 521095002419 GTP-binding protein Der; Reviewed; Region: PRK00093 521095002420 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 521095002421 G1 box; other site 521095002422 GTP/Mg2+ binding site [chemical binding]; other site 521095002423 Switch I region; other site 521095002424 G2 box; other site 521095002425 Switch II region; other site 521095002426 G3 box; other site 521095002427 G4 box; other site 521095002428 G5 box; other site 521095002429 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 521095002430 G1 box; other site 521095002431 GTP/Mg2+ binding site [chemical binding]; other site 521095002432 Switch I region; other site 521095002433 G2 box; other site 521095002434 G3 box; other site 521095002435 Switch II region; other site 521095002436 G4 box; other site 521095002437 G5 box; other site 521095002438 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 521095002439 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 521095002440 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 521095002441 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 521095002442 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 521095002443 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 521095002444 substrate binding site [chemical binding]; other site 521095002445 hexamer interface [polypeptide binding]; other site 521095002446 metal binding site [ion binding]; metal-binding site 521095002447 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 521095002448 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 521095002449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521095002450 catalytic residue [active] 521095002451 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 521095002452 Putative zinc ribbon domain; Region: DUF164; pfam02591 521095002453 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 521095002454 Flavoprotein; Region: Flavoprotein; pfam02441 521095002455 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 521095002456 endonuclease IV; Provisional; Region: PRK01060 521095002457 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 521095002458 AP (apurinic/apyrimidinic) site pocket; other site 521095002459 DNA interaction; other site 521095002460 Metal-binding active site; metal-binding site 521095002461 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521095002462 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 521095002463 ABC transporter; Region: ABC_tran_2; pfam12848 521095002464 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 521095002465 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095002466 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095002467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095002468 Walker A/P-loop; other site 521095002469 ATP binding site [chemical binding]; other site 521095002470 Q-loop/lid; other site 521095002471 ABC transporter signature motif; other site 521095002472 Walker B; other site 521095002473 D-loop; other site 521095002474 H-loop/switch region; other site 521095002475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095002476 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095002477 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 521095002478 Walker A/P-loop; other site 521095002479 ATP binding site [chemical binding]; other site 521095002480 Q-loop/lid; other site 521095002481 ABC transporter signature motif; other site 521095002482 Walker B; other site 521095002483 D-loop; other site 521095002484 H-loop/switch region; other site 521095002485 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 521095002486 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 521095002487 DNA binding site [nucleotide binding] 521095002488 active site 521095002489 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 521095002490 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 521095002491 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 521095002492 ligand binding site [chemical binding]; other site 521095002493 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 521095002494 hybrid cluster protein; Provisional; Region: PRK05290 521095002495 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 521095002496 hybrid metal cluster; other site 521095002497 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 521095002498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521095002499 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 521095002500 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521095002501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095002502 S-adenosylmethionine binding site [chemical binding]; other site 521095002503 myosin-cross-reactive antigen; Provisional; Region: PRK13977 521095002504 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521095002505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095002506 S-adenosylmethionine binding site [chemical binding]; other site 521095002507 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 521095002508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 521095002509 active site 521095002510 motif I; other site 521095002511 motif II; other site 521095002512 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 521095002513 hypothetical protein; Provisional; Region: PRK08262 521095002514 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 521095002515 metal binding site [ion binding]; metal-binding site 521095002516 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 521095002517 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 521095002518 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 521095002519 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 521095002520 homotrimer interaction site [polypeptide binding]; other site 521095002521 putative active site [active] 521095002522 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521095002523 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521095002524 phosphopeptide binding site; other site 521095002525 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 521095002526 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 521095002527 DNA binding residues [nucleotide binding] 521095002528 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095002529 active site 521095002530 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 521095002531 NlpC/P60 family; Region: NLPC_P60; cl17555 521095002532 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 521095002533 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 521095002534 Cl- selectivity filter; other site 521095002535 Cl- binding residues [ion binding]; other site 521095002536 pore gating glutamate residue; other site 521095002537 dimer interface [polypeptide binding]; other site 521095002538 H+/Cl- coupling transport residue; other site 521095002539 TrkA-C domain; Region: TrkA_C; pfam02080 521095002540 Methyltransferase domain; Region: Methyltransf_11; pfam08241 521095002541 S-adenosylmethionine binding site [chemical binding]; other site 521095002542 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 521095002543 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 521095002544 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521095002545 putative metal binding site [ion binding]; other site 521095002546 Methyltransferase domain; Region: Methyltransf_31; pfam13847 521095002547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095002548 S-adenosylmethionine binding site [chemical binding]; other site 521095002549 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 521095002550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521095002551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521095002552 Coenzyme A binding pocket [chemical binding]; other site 521095002553 A new structural DNA glycosylase; Region: AlkD_like; cd06561 521095002554 active site 521095002555 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 521095002556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521095002557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521095002558 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 521095002559 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 521095002560 trimer interface [polypeptide binding]; other site 521095002561 active site 521095002562 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 521095002563 ATP cone domain; Region: ATP-cone; pfam03477 521095002564 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 521095002565 LexA repressor; Validated; Region: PRK00215 521095002566 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521095002567 putative DNA binding site [nucleotide binding]; other site 521095002568 putative Zn2+ binding site [ion binding]; other site 521095002569 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 521095002570 Catalytic site [active] 521095002571 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 521095002572 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 521095002573 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 521095002574 HflX GTPase family; Region: HflX; cd01878 521095002575 G1 box; other site 521095002576 GTP/Mg2+ binding site [chemical binding]; other site 521095002577 Switch I region; other site 521095002578 G2 box; other site 521095002579 G3 box; other site 521095002580 Switch II region; other site 521095002581 G4 box; other site 521095002582 G5 box; other site 521095002583 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 521095002584 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 521095002585 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 521095002586 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521095002587 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095002588 FeS/SAM binding site; other site 521095002589 TRAM domain; Region: TRAM; cl01282 521095002590 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 521095002591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095002592 ATP binding site [chemical binding]; other site 521095002593 Mg2+ binding site [ion binding]; other site 521095002594 G-X-G motif; other site 521095002595 phosphodiesterase; Provisional; Region: PRK12704 521095002596 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 521095002597 Zn2+ binding site [ion binding]; other site 521095002598 Mg2+ binding site [ion binding]; other site 521095002599 recombination regulator RecX; Reviewed; Region: recX; PRK00117 521095002600 recombinase A; Provisional; Region: recA; PRK09354 521095002601 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 521095002602 hexamer interface [polypeptide binding]; other site 521095002603 Walker A motif; other site 521095002604 ATP binding site [chemical binding]; other site 521095002605 Walker B motif; other site 521095002606 Competence-damaged protein; Region: CinA; pfam02464 521095002607 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 521095002608 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 521095002609 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521095002610 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095002611 FeS/SAM binding site; other site 521095002612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 521095002613 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 521095002614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095002615 non-specific DNA binding site [nucleotide binding]; other site 521095002616 salt bridge; other site 521095002617 sequence-specific DNA binding site [nucleotide binding]; other site 521095002618 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 521095002619 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 521095002620 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 521095002621 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 521095002622 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 521095002623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521095002624 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 521095002625 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 521095002626 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 521095002627 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 521095002628 RNase E interface [polypeptide binding]; other site 521095002629 trimer interface [polypeptide binding]; other site 521095002630 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 521095002631 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 521095002632 RNase E interface [polypeptide binding]; other site 521095002633 trimer interface [polypeptide binding]; other site 521095002634 active site 521095002635 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 521095002636 putative nucleic acid binding region [nucleotide binding]; other site 521095002637 G-X-X-G motif; other site 521095002638 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 521095002639 RNA binding site [nucleotide binding]; other site 521095002640 domain interface; other site 521095002641 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 521095002642 16S/18S rRNA binding site [nucleotide binding]; other site 521095002643 S13e-L30e interaction site [polypeptide binding]; other site 521095002644 25S rRNA binding site [nucleotide binding]; other site 521095002645 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 521095002646 Recombination protein O N terminal; Region: RecO_N; pfam11967 521095002647 Recombination protein O C terminal; Region: RecO_C; pfam02565 521095002648 GTPase Era; Reviewed; Region: era; PRK00089 521095002649 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 521095002650 G1 box; other site 521095002651 GTP/Mg2+ binding site [chemical binding]; other site 521095002652 Switch I region; other site 521095002653 G2 box; other site 521095002654 Switch II region; other site 521095002655 G3 box; other site 521095002656 G4 box; other site 521095002657 G5 box; other site 521095002658 KH domain; Region: KH_2; pfam07650 521095002659 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 521095002660 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 521095002661 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 521095002662 PhoH-like protein; Region: PhoH; pfam02562 521095002663 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 521095002664 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 521095002665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095002666 FeS/SAM binding site; other site 521095002667 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 521095002668 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521095002669 HSP70 interaction site [polypeptide binding]; other site 521095002670 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 521095002671 substrate binding site [polypeptide binding]; other site 521095002672 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 521095002673 Zn binding sites [ion binding]; other site 521095002674 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 521095002675 dimer interface [polypeptide binding]; other site 521095002676 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 521095002677 HSP70 interaction site [polypeptide binding]; other site 521095002678 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 521095002679 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 521095002680 Zn binding sites [ion binding]; other site 521095002681 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 521095002682 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 521095002683 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 521095002684 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 521095002685 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 521095002686 FMN binding site [chemical binding]; other site 521095002687 active site 521095002688 catalytic residues [active] 521095002689 substrate binding site [chemical binding]; other site 521095002690 GTP-binding protein LepA; Provisional; Region: PRK05433 521095002691 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 521095002692 G1 box; other site 521095002693 putative GEF interaction site [polypeptide binding]; other site 521095002694 GTP/Mg2+ binding site [chemical binding]; other site 521095002695 Switch I region; other site 521095002696 G2 box; other site 521095002697 G3 box; other site 521095002698 Switch II region; other site 521095002699 G4 box; other site 521095002700 G5 box; other site 521095002701 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 521095002702 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 521095002703 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 521095002704 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 521095002705 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 521095002706 DNA polymerase III, delta subunit; Region: holA; TIGR01128 521095002707 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 521095002708 Competence protein; Region: Competence; pfam03772 521095002709 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 521095002710 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521095002711 SLBB domain; Region: SLBB; pfam10531 521095002712 comEA protein; Region: comE; TIGR01259 521095002713 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 521095002714 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 521095002715 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 521095002716 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 521095002717 Ligand Binding Site [chemical binding]; other site 521095002718 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 521095002719 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 521095002720 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 521095002721 catalytic site [active] 521095002722 G-X2-G-X-G-K; other site 521095002723 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 521095002724 active site 521095002725 dimer interface [polypeptide binding]; other site 521095002726 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 521095002727 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 521095002728 heterodimer interface [polypeptide binding]; other site 521095002729 active site 521095002730 FMN binding site [chemical binding]; other site 521095002731 homodimer interface [polypeptide binding]; other site 521095002732 substrate binding site [chemical binding]; other site 521095002733 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 521095002734 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 521095002735 FAD binding pocket [chemical binding]; other site 521095002736 FAD binding motif [chemical binding]; other site 521095002737 phosphate binding motif [ion binding]; other site 521095002738 beta-alpha-beta structure motif; other site 521095002739 NAD binding pocket [chemical binding]; other site 521095002740 Iron coordination center [ion binding]; other site 521095002741 dihydroorotase; Validated; Region: pyrC; PRK09357 521095002742 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521095002743 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 521095002744 active site 521095002745 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 521095002746 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 521095002747 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 521095002748 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 521095002749 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095002750 active site 521095002751 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 521095002752 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 521095002753 Walker A/P-loop; other site 521095002754 ATP binding site [chemical binding]; other site 521095002755 Q-loop/lid; other site 521095002756 ABC transporter signature motif; other site 521095002757 Walker B; other site 521095002758 D-loop; other site 521095002759 H-loop/switch region; other site 521095002760 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521095002761 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521095002762 DNA binding site [nucleotide binding] 521095002763 domain linker motif; other site 521095002764 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 521095002765 ligand binding site [chemical binding]; other site 521095002766 dimerization interface (open form) [polypeptide binding]; other site 521095002767 dimerization interface (closed form) [polypeptide binding]; other site 521095002768 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 521095002769 active site 521095002770 catalytic residues [active] 521095002771 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 521095002772 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 521095002773 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 521095002774 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 521095002775 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 521095002776 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 521095002777 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 521095002778 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 521095002779 TM-ABC transporter signature motif; other site 521095002780 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 521095002781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095002782 Walker A/P-loop; other site 521095002783 ATP binding site [chemical binding]; other site 521095002784 Q-loop/lid; other site 521095002785 ABC transporter signature motif; other site 521095002786 Walker B; other site 521095002787 D-loop; other site 521095002788 H-loop/switch region; other site 521095002789 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 521095002790 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 521095002791 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 521095002792 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 521095002793 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 521095002794 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 521095002795 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 521095002796 DNA binding residues [nucleotide binding] 521095002797 DNA primase, catalytic core; Region: dnaG; TIGR01391 521095002798 CHC2 zinc finger; Region: zf-CHC2; pfam01807 521095002799 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 521095002800 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 521095002801 active site 521095002802 metal binding site [ion binding]; metal-binding site 521095002803 interdomain interaction site; other site 521095002804 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 521095002805 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 521095002806 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 521095002807 active site 521095002808 Riboflavin kinase; Region: Flavokinase; pfam01687 521095002809 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 521095002810 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 521095002811 RNA binding site [nucleotide binding]; other site 521095002812 active site 521095002813 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 521095002814 DHH family; Region: DHH; pfam01368 521095002815 Ribosome-binding factor A; Region: RBFA; pfam02033 521095002816 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 521095002817 translation initiation factor IF-2; Region: IF-2; TIGR00487 521095002818 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 521095002819 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 521095002820 G1 box; other site 521095002821 putative GEF interaction site [polypeptide binding]; other site 521095002822 GTP/Mg2+ binding site [chemical binding]; other site 521095002823 Switch I region; other site 521095002824 G2 box; other site 521095002825 G3 box; other site 521095002826 Switch II region; other site 521095002827 G4 box; other site 521095002828 G5 box; other site 521095002829 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 521095002830 Translation-initiation factor 2; Region: IF-2; pfam11987 521095002831 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 521095002832 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 521095002833 NusA N-terminal domain; Region: NusA_N; pfam08529 521095002834 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 521095002835 RNA binding site [nucleotide binding]; other site 521095002836 homodimer interface [polypeptide binding]; other site 521095002837 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 521095002838 G-X-X-G motif; other site 521095002839 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 521095002840 G-X-X-G motif; other site 521095002841 ribosome maturation protein RimP; Reviewed; Region: PRK00092 521095002842 Sm and related proteins; Region: Sm_like; cl00259 521095002843 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 521095002844 putative oligomer interface [polypeptide binding]; other site 521095002845 putative RNA binding site [nucleotide binding]; other site 521095002846 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 521095002847 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 521095002848 HIGH motif; other site 521095002849 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521095002850 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 521095002851 active site 521095002852 KMSKS motif; other site 521095002853 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 521095002854 tRNA binding surface [nucleotide binding]; other site 521095002855 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 521095002856 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 521095002857 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 521095002858 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 521095002859 active site 521095002860 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 521095002861 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 521095002862 DXD motif; other site 521095002863 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095002864 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095002865 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 521095002866 Walker A/P-loop; other site 521095002867 ATP binding site [chemical binding]; other site 521095002868 Q-loop/lid; other site 521095002869 ABC transporter signature motif; other site 521095002870 Walker B; other site 521095002871 D-loop; other site 521095002872 H-loop/switch region; other site 521095002873 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095002874 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 521095002875 Walker A/P-loop; other site 521095002876 ATP binding site [chemical binding]; other site 521095002877 Q-loop/lid; other site 521095002878 ABC transporter signature motif; other site 521095002879 Walker B; other site 521095002880 D-loop; other site 521095002881 H-loop/switch region; other site 521095002882 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 521095002883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 521095002884 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 521095002885 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521095002886 RNA binding surface [nucleotide binding]; other site 521095002887 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 521095002888 active site 521095002889 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 521095002890 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 521095002891 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095002892 active site 521095002893 HIGH motif; other site 521095002894 nucleotide binding site [chemical binding]; other site 521095002895 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 521095002896 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 521095002897 active site 521095002898 KMSKS motif; other site 521095002899 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 521095002900 tRNA binding surface [nucleotide binding]; other site 521095002901 anticodon binding site; other site 521095002902 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 521095002903 FtsH Extracellular; Region: FtsH_ext; pfam06480 521095002904 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 521095002905 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 521095002906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095002907 Walker A motif; other site 521095002908 ATP binding site [chemical binding]; other site 521095002909 Walker B motif; other site 521095002910 arginine finger; other site 521095002911 Peptidase family M41; Region: Peptidase_M41; pfam01434 521095002912 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521095002913 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521095002914 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521095002915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095002916 non-specific DNA binding site [nucleotide binding]; other site 521095002917 salt bridge; other site 521095002918 sequence-specific DNA binding site [nucleotide binding]; other site 521095002919 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 521095002920 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 521095002921 Acyltransferase family; Region: Acyl_transf_3; pfam01757 521095002922 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 521095002923 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 521095002924 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 521095002925 Protein of unknown function (DUF454); Region: DUF454; cl01063 521095002926 signal recognition particle protein; Provisional; Region: PRK10867 521095002927 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 521095002928 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521095002929 P loop; other site 521095002930 GTP binding site [chemical binding]; other site 521095002931 Signal peptide binding domain; Region: SRP_SPB; pfam02978 521095002932 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 521095002933 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 521095002934 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 521095002935 P loop; other site 521095002936 GTP binding site [chemical binding]; other site 521095002937 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521095002938 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 521095002939 Walker A/P-loop; other site 521095002940 ATP binding site [chemical binding]; other site 521095002941 Q-loop/lid; other site 521095002942 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 521095002943 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 521095002944 ABC transporter signature motif; other site 521095002945 Walker B; other site 521095002946 D-loop; other site 521095002947 H-loop/switch region; other site 521095002948 ribonuclease III; Reviewed; Region: rnc; PRK00102 521095002949 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 521095002950 dimerization interface [polypeptide binding]; other site 521095002951 active site 521095002952 metal binding site [ion binding]; metal-binding site 521095002953 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 521095002954 dsRNA binding site [nucleotide binding]; other site 521095002955 Phosphopantetheine attachment site; Region: PP-binding; cl09936 521095002956 putative phosphate acyltransferase; Provisional; Region: PRK05331 521095002957 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 521095002958 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 521095002959 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 521095002960 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 521095002961 active site 521095002962 (T/H)XGH motif; other site 521095002963 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 521095002964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095002965 S-adenosylmethionine binding site [chemical binding]; other site 521095002966 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 521095002967 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 521095002968 generic binding surface II; other site 521095002969 ssDNA binding site; other site 521095002970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521095002971 ATP binding site [chemical binding]; other site 521095002972 putative Mg++ binding site [ion binding]; other site 521095002973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095002974 nucleotide binding region [chemical binding]; other site 521095002975 ATP-binding site [chemical binding]; other site 521095002976 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 521095002977 DAK2 domain; Region: Dak2; pfam02734 521095002978 Asp23 family; Region: Asp23; pfam03780 521095002979 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 521095002980 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 521095002981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521095002982 motif II; other site 521095002983 Thiamine pyrophosphokinase; Region: TPK; cd07995 521095002984 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 521095002985 active site 521095002986 dimerization interface [polypeptide binding]; other site 521095002987 thiamine binding site [chemical binding]; other site 521095002988 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 521095002989 NusB family; Region: NusB; pfam01029 521095002990 putative RNA binding site [nucleotide binding]; other site 521095002991 16S rRNA methyltransferase B; Provisional; Region: PRK14902 521095002992 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 521095002993 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 521095002994 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 521095002995 putative active site [active] 521095002996 substrate binding site [chemical binding]; other site 521095002997 putative cosubstrate binding site; other site 521095002998 catalytic site [active] 521095002999 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 521095003000 substrate binding site [chemical binding]; other site 521095003001 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 521095003002 active site 521095003003 catalytic residues [active] 521095003004 metal binding site [ion binding]; metal-binding site 521095003005 primosome assembly protein PriA; Validated; Region: PRK05580 521095003006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521095003007 ATP binding site [chemical binding]; other site 521095003008 putative Mg++ binding site [ion binding]; other site 521095003009 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 521095003010 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095003011 nucleotide binding region [chemical binding]; other site 521095003012 ATP-binding site [chemical binding]; other site 521095003013 Part of AAA domain; Region: AAA_19; pfam13245 521095003014 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 521095003015 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 521095003016 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 521095003017 Protein of unknown function (DUF328); Region: DUF328; cl01143 521095003018 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 521095003019 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 521095003020 Membrane protein of unknown function; Region: DUF360; pfam04020 521095003021 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 521095003022 dimerization domain swap beta strand [polypeptide binding]; other site 521095003023 regulatory protein interface [polypeptide binding]; other site 521095003024 active site 521095003025 regulatory phosphorylation site [posttranslational modification]; other site 521095003026 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 521095003027 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 521095003028 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 521095003029 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 521095003030 CAAX protease self-immunity; Region: Abi; pfam02517 521095003031 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 521095003032 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095003033 active site 521095003034 HIGH motif; other site 521095003035 nucleotide binding site [chemical binding]; other site 521095003036 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 521095003037 KMSKS motif; other site 521095003038 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521095003039 tRNA binding surface [nucleotide binding]; other site 521095003040 anticodon binding site; other site 521095003041 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521095003042 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 521095003043 catalytic site [active] 521095003044 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521095003045 MarR family; Region: MarR_2; pfam12802 521095003046 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095003047 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095003048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095003049 Walker A/P-loop; other site 521095003050 ATP binding site [chemical binding]; other site 521095003051 Q-loop/lid; other site 521095003052 ABC transporter signature motif; other site 521095003053 Walker B; other site 521095003054 D-loop; other site 521095003055 H-loop/switch region; other site 521095003056 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095003057 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095003058 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 521095003059 Walker A/P-loop; other site 521095003060 ATP binding site [chemical binding]; other site 521095003061 Q-loop/lid; other site 521095003062 ABC transporter signature motif; other site 521095003063 Walker B; other site 521095003064 D-loop; other site 521095003065 H-loop/switch region; other site 521095003066 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 521095003067 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 521095003068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521095003069 binding surface 521095003070 TPR motif; other site 521095003071 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 521095003072 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 521095003073 active site 521095003074 metal binding site [ion binding]; metal-binding site 521095003075 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 521095003076 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 521095003077 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 521095003078 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 521095003079 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 521095003080 DNA-binding site [nucleotide binding]; DNA binding site 521095003081 RNA-binding motif; other site 521095003082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 521095003083 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 521095003084 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 521095003085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 521095003086 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 521095003087 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 521095003088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095003089 Walker A motif; other site 521095003090 ATP binding site [chemical binding]; other site 521095003091 Walker B motif; other site 521095003092 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 521095003093 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 521095003094 RuvA N terminal domain; Region: RuvA_N; pfam01330 521095003095 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 521095003096 active site 521095003097 putative DNA-binding cleft [nucleotide binding]; other site 521095003098 dimer interface [polypeptide binding]; other site 521095003099 Predicted amidohydrolase [General function prediction only]; Region: COG0388 521095003100 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 521095003101 active site 521095003102 catalytic triad [active] 521095003103 dimer interface [polypeptide binding]; other site 521095003104 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 521095003105 Ligand Binding Site [chemical binding]; other site 521095003106 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 521095003107 non-heme iron binding site [ion binding]; other site 521095003108 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 521095003109 PHP domain; Region: PHP; pfam02811 521095003110 active site 521095003111 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 521095003112 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 521095003113 active site 521095003114 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 521095003115 generic binding surface II; other site 521095003116 generic binding surface I; other site 521095003117 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 521095003118 trimer interface [polypeptide binding]; other site 521095003119 active site 521095003120 G bulge; other site 521095003121 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 521095003122 trimer interface [polypeptide binding]; other site 521095003123 active site 521095003124 G bulge; other site 521095003125 Uncharacterized conserved protein [Function unknown]; Region: COG1739 521095003126 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 521095003127 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 521095003128 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 521095003129 HPr interaction site; other site 521095003130 glycerol kinase (GK) interaction site [polypeptide binding]; other site 521095003131 active site 521095003132 phosphorylation site [posttranslational modification] 521095003133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095003134 S-adenosylmethionine binding site [chemical binding]; other site 521095003135 histone acetyltransferase, ELP3 family; Region: ELP3; TIGR01211 521095003136 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 521095003137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 521095003138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 521095003139 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 521095003140 catalytic residue [active] 521095003141 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 521095003142 peroxiredoxin; Region: AhpC; TIGR03137 521095003143 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 521095003144 dimer interface [polypeptide binding]; other site 521095003145 decamer (pentamer of dimers) interface [polypeptide binding]; other site 521095003146 catalytic triad [active] 521095003147 peroxidatic and resolving cysteines [active] 521095003148 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 521095003149 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 521095003150 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 521095003151 Ligand Binding Site [chemical binding]; other site 521095003152 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 521095003153 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 521095003154 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 521095003155 catalytic residue [active] 521095003156 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 521095003157 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521095003158 anti sigma factor interaction site; other site 521095003159 regulatory phosphorylation site [posttranslational modification]; other site 521095003160 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 521095003161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095003162 ATP binding site [chemical binding]; other site 521095003163 Mg2+ binding site [ion binding]; other site 521095003164 G-X-G motif; other site 521095003165 PAS domain; Region: PAS_9; pfam13426 521095003166 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 521095003167 GAF domain; Region: GAF_3; pfam13492 521095003168 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 521095003169 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 521095003170 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 521095003171 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521095003172 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 521095003173 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521095003174 Walker A/P-loop; other site 521095003175 ATP binding site [chemical binding]; other site 521095003176 Q-loop/lid; other site 521095003177 ABC transporter signature motif; other site 521095003178 Walker B; other site 521095003179 D-loop; other site 521095003180 H-loop/switch region; other site 521095003181 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 521095003182 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521095003183 Walker A/P-loop; other site 521095003184 ATP binding site [chemical binding]; other site 521095003185 Q-loop/lid; other site 521095003186 ABC transporter signature motif; other site 521095003187 Walker B; other site 521095003188 D-loop; other site 521095003189 H-loop/switch region; other site 521095003190 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521095003191 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 521095003192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003193 dimer interface [polypeptide binding]; other site 521095003194 conserved gate region; other site 521095003195 ABC-ATPase subunit interface; other site 521095003196 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521095003197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003198 dimer interface [polypeptide binding]; other site 521095003199 conserved gate region; other site 521095003200 putative PBP binding loops; other site 521095003201 ABC-ATPase subunit interface; other site 521095003202 Preprotein translocase SecG subunit; Region: SecG; pfam03840 521095003203 triosephosphate isomerase; Provisional; Region: PRK14567 521095003204 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 521095003205 substrate binding site [chemical binding]; other site 521095003206 dimer interface [polypeptide binding]; other site 521095003207 catalytic triad [active] 521095003208 Phosphoglycerate kinase; Region: PGK; pfam00162 521095003209 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 521095003210 substrate binding site [chemical binding]; other site 521095003211 hinge regions; other site 521095003212 ADP binding site [chemical binding]; other site 521095003213 catalytic site [active] 521095003214 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 521095003215 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 521095003216 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 521095003217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 521095003218 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 521095003219 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 521095003220 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 521095003221 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 521095003222 putative active site cavity [active] 521095003223 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 521095003224 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 521095003225 nucleotide binding site [chemical binding]; other site 521095003226 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 521095003227 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 521095003228 active site 521095003229 inhibitor site; inhibition site 521095003230 dimer interface [polypeptide binding]; other site 521095003231 catalytic residue [active] 521095003232 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 521095003233 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 521095003234 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 521095003235 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521095003236 Walker A/P-loop; other site 521095003237 ATP binding site [chemical binding]; other site 521095003238 Q-loop/lid; other site 521095003239 ABC transporter signature motif; other site 521095003240 Walker B; other site 521095003241 D-loop; other site 521095003242 H-loop/switch region; other site 521095003243 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521095003244 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 521095003245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003246 dimer interface [polypeptide binding]; other site 521095003247 conserved gate region; other site 521095003248 putative PBP binding loops; other site 521095003249 ABC-ATPase subunit interface; other site 521095003250 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 521095003251 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521095003252 Walker A/P-loop; other site 521095003253 ATP binding site [chemical binding]; other site 521095003254 Q-loop/lid; other site 521095003255 ABC transporter signature motif; other site 521095003256 Walker B; other site 521095003257 D-loop; other site 521095003258 H-loop/switch region; other site 521095003259 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 521095003260 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521095003261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003262 dimer interface [polypeptide binding]; other site 521095003263 conserved gate region; other site 521095003264 putative PBP binding loops; other site 521095003265 ABC-ATPase subunit interface; other site 521095003266 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 521095003267 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521095003268 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 521095003269 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 521095003270 GIY-YIG motif/motif A; other site 521095003271 active site 521095003272 catalytic site [active] 521095003273 putative DNA binding site [nucleotide binding]; other site 521095003274 metal binding site [ion binding]; metal-binding site 521095003275 UvrB/uvrC motif; Region: UVR; pfam02151 521095003276 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 521095003277 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 521095003278 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 521095003279 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 521095003280 putative deacylase active site [active] 521095003281 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 521095003282 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521095003283 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 521095003284 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 521095003285 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 521095003286 Domain of unknown function (DUF386); Region: DUF386; cl01047 521095003287 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 521095003288 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 521095003289 flavoprotein, HI0933 family; Region: TIGR00275 521095003290 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 521095003291 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 521095003292 excinuclease ABC subunit B; Provisional; Region: PRK05298 521095003293 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 521095003294 ATP binding site [chemical binding]; other site 521095003295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 521095003296 nucleotide binding region [chemical binding]; other site 521095003297 ATP-binding site [chemical binding]; other site 521095003298 Ultra-violet resistance protein B; Region: UvrB; pfam12344 521095003299 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 521095003300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521095003301 TPR motif; other site 521095003302 binding surface 521095003303 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 521095003304 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 521095003305 CoA-binding site [chemical binding]; other site 521095003306 ATP-binding [chemical binding]; other site 521095003307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095003308 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 521095003309 Walker A/P-loop; other site 521095003310 ATP binding site [chemical binding]; other site 521095003311 Q-loop/lid; other site 521095003312 ABC transporter signature motif; other site 521095003313 Walker B; other site 521095003314 D-loop; other site 521095003315 H-loop/switch region; other site 521095003316 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 521095003317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003318 dimer interface [polypeptide binding]; other site 521095003319 conserved gate region; other site 521095003320 putative PBP binding loops; other site 521095003321 ABC-ATPase subunit interface; other site 521095003322 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 521095003323 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 521095003324 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 521095003325 metal binding site [ion binding]; metal-binding site 521095003326 peptidase T; Region: peptidase-T; TIGR01882 521095003327 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 521095003328 metal binding site [ion binding]; metal-binding site 521095003329 dimer interface [polypeptide binding]; other site 521095003330 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 521095003331 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 521095003332 catalytic triad [active] 521095003333 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 521095003334 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 521095003335 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 521095003336 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521095003337 Walker A/P-loop; other site 521095003338 ATP binding site [chemical binding]; other site 521095003339 Q-loop/lid; other site 521095003340 ABC transporter signature motif; other site 521095003341 Walker B; other site 521095003342 D-loop; other site 521095003343 H-loop/switch region; other site 521095003344 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 521095003345 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 521095003346 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 521095003347 Walker A/P-loop; other site 521095003348 ATP binding site [chemical binding]; other site 521095003349 Q-loop/lid; other site 521095003350 ABC transporter signature motif; other site 521095003351 Walker B; other site 521095003352 D-loop; other site 521095003353 H-loop/switch region; other site 521095003354 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 521095003355 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 521095003356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003357 dimer interface [polypeptide binding]; other site 521095003358 conserved gate region; other site 521095003359 putative PBP binding loops; other site 521095003360 ABC-ATPase subunit interface; other site 521095003361 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 521095003362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 521095003363 dimer interface [polypeptide binding]; other site 521095003364 conserved gate region; other site 521095003365 putative PBP binding loops; other site 521095003366 ABC-ATPase subunit interface; other site 521095003367 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 521095003368 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 521095003369 Collagen binding domain; Region: Collagen_bind; pfam05737 521095003370 Cna protein B-type domain; Region: Cna_B; pfam05738 521095003371 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 521095003372 domain interaction interfaces [polypeptide binding]; other site 521095003373 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 521095003374 domain interaction interfaces [polypeptide binding]; other site 521095003375 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 521095003376 domain interaction interfaces [polypeptide binding]; other site 521095003377 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 521095003378 domain interaction interfaces [polypeptide binding]; other site 521095003379 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 521095003380 domain interaction interfaces [polypeptide binding]; other site 521095003381 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 521095003382 RNA binding site [nucleotide binding]; other site 521095003383 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 521095003384 RNA binding site [nucleotide binding]; other site 521095003385 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 521095003386 RNA binding site [nucleotide binding]; other site 521095003387 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521095003388 RNA binding site [nucleotide binding]; other site 521095003389 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 521095003390 metal-binding site [ion binding] 521095003391 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 521095003392 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 521095003393 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 521095003394 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095003395 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 521095003396 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 521095003397 catalytic residues [active] 521095003398 dimer interface [polypeptide binding]; other site 521095003399 MarR family; Region: MarR_2; cl17246 521095003400 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 521095003401 Cation efflux family; Region: Cation_efflux; pfam01545 521095003402 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 521095003403 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 521095003404 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 521095003405 G1 box; other site 521095003406 GTP/Mg2+ binding site [chemical binding]; other site 521095003407 Switch I region; other site 521095003408 G2 box; other site 521095003409 G3 box; other site 521095003410 Switch II region; other site 521095003411 G4 box; other site 521095003412 G5 box; other site 521095003413 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 521095003414 Nucleoside recognition; Region: Gate; pfam07670 521095003415 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 521095003416 Nucleoside recognition; Region: Gate; pfam07670 521095003417 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 521095003418 FeoA domain; Region: FeoA; pfam04023 521095003419 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 521095003420 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 521095003421 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 521095003422 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 521095003423 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 521095003424 C-terminal domain interface [polypeptide binding]; other site 521095003425 GSH binding site (G-site) [chemical binding]; other site 521095003426 dimer interface [polypeptide binding]; other site 521095003427 Uncharacterized conserved protein [Function unknown]; Region: COG1683 521095003428 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 521095003429 trigger factor; Provisional; Region: tig; PRK01490 521095003430 Uncharacterized conserved protein [Function unknown]; Region: COG1432 521095003431 LabA_like proteins; Region: LabA_like; cd06167 521095003432 putative metal binding site [ion binding]; other site 521095003433 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 521095003434 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 521095003435 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 521095003436 EDD domain protein, DegV family; Region: DegV; TIGR00762 521095003437 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 521095003438 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 521095003439 30S subunit binding site; other site 521095003440 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 521095003441 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 521095003442 substrate binding pocket [chemical binding]; other site 521095003443 membrane-bound complex binding site; other site 521095003444 hinge residues; other site 521095003445 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 521095003446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095003447 active site 521095003448 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 521095003449 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 521095003450 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 521095003451 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521095003452 Walker A/P-loop; other site 521095003453 ATP binding site [chemical binding]; other site 521095003454 Q-loop/lid; other site 521095003455 ABC transporter signature motif; other site 521095003456 Walker B; other site 521095003457 D-loop; other site 521095003458 H-loop/switch region; other site 521095003459 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521095003460 Walker A/P-loop; other site 521095003461 ATP binding site [chemical binding]; other site 521095003462 Q-loop/lid; other site 521095003463 ABC transporter signature motif; other site 521095003464 Walker B; other site 521095003465 D-loop; other site 521095003466 H-loop/switch region; other site 521095003467 PQQ-like domain; Region: PQQ_2; pfam13360 521095003468 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 521095003469 Trp docking motif [polypeptide binding]; other site 521095003470 active site 521095003471 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 521095003472 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 521095003473 trimer interface [polypeptide binding]; other site 521095003474 active site 521095003475 NifU-like domain; Region: NifU; cl00484 521095003476 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 521095003477 Peptidase family U32; Region: Peptidase_U32; pfam01136 521095003478 Collagenase; Region: DUF3656; pfam12392 521095003479 Peptidase family U32; Region: Peptidase_U32; cl03113 521095003480 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 521095003481 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 521095003482 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 521095003483 Ligand binding site; other site 521095003484 Putative Catalytic site; other site 521095003485 DXD motif; other site 521095003486 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 521095003487 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 521095003488 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 521095003489 LicD family; Region: LicD; pfam04991 521095003490 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521095003491 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521095003492 active site 521095003493 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 521095003494 Transcriptional regulators [Transcription]; Region: MarR; COG1846 521095003495 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 521095003496 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 521095003497 active site 521095003498 metal-binding site 521095003499 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 521095003500 active site 521095003501 substrate binding site [chemical binding]; other site 521095003502 ATP binding site [chemical binding]; other site 521095003503 Phosphotransferase enzyme family; Region: APH; pfam01636 521095003504 LicD family; Region: LicD; cl01378 521095003505 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 521095003506 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 521095003507 NAD binding site [chemical binding]; other site 521095003508 substrate binding site [chemical binding]; other site 521095003509 homodimer interface [polypeptide binding]; other site 521095003510 active site 521095003511 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 521095003512 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 521095003513 NADP binding site [chemical binding]; other site 521095003514 active site 521095003515 putative substrate binding site [chemical binding]; other site 521095003516 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 521095003517 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 521095003518 substrate binding site; other site 521095003519 tetramer interface; other site 521095003520 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 521095003521 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 521095003522 active site 521095003523 HIGH motif; other site 521095003524 dimer interface [polypeptide binding]; other site 521095003525 KMSKS motif; other site 521095003526 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521095003527 RNA binding surface [nucleotide binding]; other site 521095003528 Transglycosylase; Region: Transgly; pfam00912 521095003529 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 521095003530 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 521095003531 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 521095003532 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 521095003533 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 521095003534 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 521095003535 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 521095003536 active site 521095003537 substrate binding site [chemical binding]; other site 521095003538 metal binding site [ion binding]; metal-binding site 521095003539 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 521095003540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095003541 S-adenosylmethionine binding site [chemical binding]; other site 521095003542 K+ potassium transporter; Region: K_trans; pfam02705 521095003543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 521095003544 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 521095003545 active site 521095003546 motif I; other site 521095003547 motif II; other site 521095003548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 521095003549 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 521095003550 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 521095003551 active site 521095003552 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 521095003553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095003554 non-specific DNA binding site [nucleotide binding]; other site 521095003555 salt bridge; other site 521095003556 sequence-specific DNA binding site [nucleotide binding]; other site 521095003557 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 521095003558 TadE-like protein; Region: TadE; pfam07811 521095003559 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 521095003560 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 521095003561 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 521095003562 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 521095003563 ATP binding site [chemical binding]; other site 521095003564 Walker A motif; other site 521095003565 hexamer interface [polypeptide binding]; other site 521095003566 Walker B motif; other site 521095003567 AAA domain; Region: AAA_31; pfam13614 521095003568 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521095003569 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 521095003570 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 521095003571 Predicted GTPases [General function prediction only]; Region: COG1162 521095003572 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 521095003573 RNA binding site [nucleotide binding]; other site 521095003574 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 521095003575 GTPase/Zn-binding domain interface [polypeptide binding]; other site 521095003576 GTP/Mg2+ binding site [chemical binding]; other site 521095003577 G4 box; other site 521095003578 G5 box; other site 521095003579 G1 box; other site 521095003580 Switch I region; other site 521095003581 G2 box; other site 521095003582 G3 box; other site 521095003583 Switch II region; other site 521095003584 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 521095003585 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 521095003586 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095003587 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 521095003588 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 521095003589 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 521095003590 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 521095003591 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 521095003592 putative ligand binding site [chemical binding]; other site 521095003593 putative NAD binding site [chemical binding]; other site 521095003594 catalytic site [active] 521095003595 pyruvate kinase; Provisional; Region: PRK05826 521095003596 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 521095003597 domain interfaces; other site 521095003598 active site 521095003599 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095003600 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095003601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095003602 Walker A/P-loop; other site 521095003603 ATP binding site [chemical binding]; other site 521095003604 Q-loop/lid; other site 521095003605 ABC transporter signature motif; other site 521095003606 Walker B; other site 521095003607 D-loop; other site 521095003608 H-loop/switch region; other site 521095003609 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 521095003610 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095003611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095003612 Walker A/P-loop; other site 521095003613 ATP binding site [chemical binding]; other site 521095003614 Q-loop/lid; other site 521095003615 ABC transporter signature motif; other site 521095003616 Walker B; other site 521095003617 D-loop; other site 521095003618 H-loop/switch region; other site 521095003619 nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369 521095003620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521095003621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095003622 active site 521095003623 phosphorylation site [posttranslational modification] 521095003624 intermolecular recognition site; other site 521095003625 dimerization interface [polypeptide binding]; other site 521095003626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095003627 DNA binding site [nucleotide binding] 521095003628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521095003629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521095003630 dimer interface [polypeptide binding]; other site 521095003631 phosphorylation site [posttranslational modification] 521095003632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095003633 ATP binding site [chemical binding]; other site 521095003634 Mg2+ binding site [ion binding]; other site 521095003635 G-X-G motif; other site 521095003636 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 521095003637 homodimer interface [polypeptide binding]; other site 521095003638 putative bifunctional 4-alpha-glucanotransferase/glycogen debranching enzyme; Provisional; Region: PRK14510 521095003639 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 521095003640 active site 521095003641 homodimer interface [polypeptide binding]; other site 521095003642 catalytic site [active] 521095003643 4-alpha-glucanotransferase; Provisional; Region: PRK14508 521095003644 glycogen synthase; Provisional; Region: glgA; PRK00654 521095003645 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 521095003646 ADP-binding pocket [chemical binding]; other site 521095003647 homodimer interface [polypeptide binding]; other site 521095003648 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 521095003649 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 521095003650 ligand binding site; other site 521095003651 oligomer interface; other site 521095003652 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 521095003653 dimer interface [polypeptide binding]; other site 521095003654 N-terminal domain interface [polypeptide binding]; other site 521095003655 sulfate 1 binding site; other site 521095003656 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 521095003657 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 521095003658 ligand binding site; other site 521095003659 oligomer interface; other site 521095003660 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 521095003661 dimer interface [polypeptide binding]; other site 521095003662 N-terminal domain interface [polypeptide binding]; other site 521095003663 sulfate 1 binding site; other site 521095003664 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 521095003665 homodimer interface [polypeptide binding]; other site 521095003666 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 521095003667 active site pocket [active] 521095003668 glycogen branching enzyme; Provisional; Region: PRK12313 521095003669 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 521095003670 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 521095003671 active site 521095003672 catalytic site [active] 521095003673 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 521095003674 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 521095003675 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 521095003676 active site 521095003677 NAD binding site [chemical binding]; other site 521095003678 metal binding site [ion binding]; metal-binding site 521095003679 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 521095003680 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 521095003681 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 521095003682 putative tRNA-binding site [nucleotide binding]; other site 521095003683 B3/4 domain; Region: B3_4; pfam03483 521095003684 tRNA synthetase B5 domain; Region: B5; pfam03484 521095003685 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 521095003686 dimer interface [polypeptide binding]; other site 521095003687 motif 1; other site 521095003688 motif 3; other site 521095003689 motif 2; other site 521095003690 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 521095003691 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 521095003692 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 521095003693 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 521095003694 dimer interface [polypeptide binding]; other site 521095003695 motif 1; other site 521095003696 active site 521095003697 motif 2; other site 521095003698 motif 3; other site 521095003699 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 521095003700 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 521095003701 ABC-ATPase subunit interface; other site 521095003702 dimer interface [polypeptide binding]; other site 521095003703 putative PBP binding regions; other site 521095003704 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 521095003705 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 521095003706 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 521095003707 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 521095003708 metal binding site [ion binding]; metal-binding site 521095003709 Predicted membrane protein [Function unknown]; Region: COG2323 521095003710 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 521095003711 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 521095003712 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 521095003713 active site 521095003714 dimer interface [polypeptide binding]; other site 521095003715 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 521095003716 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 521095003717 dimer interface [polypeptide binding]; other site 521095003718 active site 521095003719 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 521095003720 putative active site [active] 521095003721 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 521095003722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095003723 DNA-binding site [nucleotide binding]; DNA binding site 521095003724 UTRA domain; Region: UTRA; pfam07702 521095003725 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 521095003726 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 521095003727 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 521095003728 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 521095003729 active site 521095003730 phosphorylation site [posttranslational modification] 521095003731 Preprotein translocase subunit; Region: YajC; pfam02699 521095003732 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 521095003733 active pocket/dimerization site; other site 521095003734 active site 521095003735 phosphorylation site [posttranslational modification] 521095003736 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 521095003737 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 521095003738 putative substrate binding site [chemical binding]; other site 521095003739 putative ATP binding site [chemical binding]; other site 521095003740 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 521095003741 intersubunit interface [polypeptide binding]; other site 521095003742 active site 521095003743 zinc binding site [ion binding]; other site 521095003744 Na+ binding site [ion binding]; other site 521095003745 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 521095003746 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 521095003747 homodimer interface [polypeptide binding]; other site 521095003748 substrate-cofactor binding pocket; other site 521095003749 catalytic residue [active] 521095003750 Uncharacterized conserved protein [Function unknown]; Region: COG3189 521095003751 glutamate racemase; Provisional; Region: PRK00865 521095003752 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 521095003753 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 521095003754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 521095003755 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 521095003756 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 521095003757 HPr interaction site; other site 521095003758 glycerol kinase (GK) interaction site [polypeptide binding]; other site 521095003759 active site 521095003760 phosphorylation site [posttranslational modification] 521095003761 FtsX-like permease family; Region: FtsX; pfam02687 521095003762 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095003763 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521095003764 Walker A/P-loop; other site 521095003765 ATP binding site [chemical binding]; other site 521095003766 Q-loop/lid; other site 521095003767 ABC transporter signature motif; other site 521095003768 Walker B; other site 521095003769 D-loop; other site 521095003770 H-loop/switch region; other site 521095003771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 521095003772 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 521095003773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521095003774 Coenzyme A binding pocket [chemical binding]; other site 521095003775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521095003776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095003777 ATP binding site [chemical binding]; other site 521095003778 Mg2+ binding site [ion binding]; other site 521095003779 G-X-G motif; other site 521095003780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521095003781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095003782 active site 521095003783 phosphorylation site [posttranslational modification] 521095003784 intermolecular recognition site; other site 521095003785 dimerization interface [polypeptide binding]; other site 521095003786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095003787 DNA binding site [nucleotide binding] 521095003788 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 521095003789 active site 521095003790 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 521095003791 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 521095003792 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 521095003793 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 521095003794 active site 521095003795 HIGH motif; other site 521095003796 KMSKS motif; other site 521095003797 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 521095003798 tRNA binding surface [nucleotide binding]; other site 521095003799 anticodon binding site; other site 521095003800 Predicted methyltransferases [General function prediction only]; Region: COG0313 521095003801 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 521095003802 putative SAM binding site [chemical binding]; other site 521095003803 putative homodimer interface [polypeptide binding]; other site 521095003804 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 521095003805 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 521095003806 active site 521095003807 PSP1 C-terminal conserved region; Region: PSP1; cl00770 521095003808 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 521095003809 DNA polymerase III subunit delta'; Validated; Region: PRK08485 521095003810 DNA polymerase III subunit delta'; Validated; Region: PRK05564 521095003811 thymidylate kinase; Validated; Region: tmk; PRK00698 521095003812 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 521095003813 TMP-binding site; other site 521095003814 ATP-binding site [chemical binding]; other site 521095003815 DNA topoisomerase I; Validated; Region: PRK07219 521095003816 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 521095003817 active site 521095003818 putative interdomain interaction site [polypeptide binding]; other site 521095003819 putative metal-binding site [ion binding]; other site 521095003820 putative nucleotide binding site [chemical binding]; other site 521095003821 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 521095003822 domain I; other site 521095003823 DNA binding groove [nucleotide binding] 521095003824 phosphate binding site [ion binding]; other site 521095003825 domain II; other site 521095003826 domain III; other site 521095003827 nucleotide binding site [chemical binding]; other site 521095003828 catalytic site [active] 521095003829 domain IV; other site 521095003830 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 521095003831 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 521095003832 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 521095003833 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 521095003834 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 521095003835 anti sigma factor interaction site; other site 521095003836 regulatory phosphorylation site [posttranslational modification]; other site 521095003837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521095003838 TPR motif; other site 521095003839 binding surface 521095003840 Tetratricopeptide repeat; Region: TPR_16; pfam13432 521095003841 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 521095003842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 521095003843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 521095003844 homodimer interface [polypeptide binding]; other site 521095003845 catalytic residue [active] 521095003846 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 521095003847 EDD domain protein, DegV family; Region: DegV; TIGR00762 521095003848 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 521095003849 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 521095003850 RNA/DNA hybrid binding site [nucleotide binding]; other site 521095003851 active site 521095003852 DNA polymerase I; Provisional; Region: PRK05755 521095003853 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 521095003854 active site 521095003855 metal binding site 1 [ion binding]; metal-binding site 521095003856 putative 5' ssDNA interaction site; other site 521095003857 metal binding site 3; metal-binding site 521095003858 metal binding site 2 [ion binding]; metal-binding site 521095003859 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 521095003860 putative DNA binding site [nucleotide binding]; other site 521095003861 putative metal binding site [ion binding]; other site 521095003862 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 521095003863 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 521095003864 active site 521095003865 DNA binding site [nucleotide binding] 521095003866 catalytic site [active] 521095003867 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 521095003868 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 521095003869 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 521095003870 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 521095003871 Predicted membrane protein [Function unknown]; Region: COG1971 521095003872 Domain of unknown function DUF; Region: DUF204; pfam02659 521095003873 Domain of unknown function DUF; Region: DUF204; pfam02659 521095003874 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 521095003875 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 521095003876 ArsC family; Region: ArsC; pfam03960 521095003877 putative ArsC-like catalytic residues; other site 521095003878 putative TRX-like catalytic residues [active] 521095003879 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 521095003880 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 521095003881 nucleotide binding pocket [chemical binding]; other site 521095003882 K-X-D-G motif; other site 521095003883 catalytic site [active] 521095003884 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 521095003885 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 521095003886 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 521095003887 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 521095003888 Dimer interface [polypeptide binding]; other site 521095003889 BRCT sequence motif; other site 521095003890 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 521095003891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 521095003892 active site 521095003893 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 521095003894 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 521095003895 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 521095003896 Ligand binding site; other site 521095003897 metal-binding site 521095003898 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521095003899 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 521095003900 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 521095003901 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 521095003902 FtsX-like permease family; Region: FtsX; pfam02687 521095003903 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 521095003904 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095003905 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 521095003906 Walker A/P-loop; other site 521095003907 ATP binding site [chemical binding]; other site 521095003908 Q-loop/lid; other site 521095003909 ABC transporter signature motif; other site 521095003910 Walker B; other site 521095003911 D-loop; other site 521095003912 H-loop/switch region; other site 521095003913 DNA polymerase IV; Reviewed; Region: PRK03103 521095003914 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 521095003915 active site 521095003916 DNA binding site [nucleotide binding] 521095003917 DJ-1 family protein; Region: not_thiJ; TIGR01383 521095003918 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 521095003919 conserved cys residue [active] 521095003920 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521095003921 active site 521095003922 phosphorylation site [posttranslational modification] 521095003923 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 521095003924 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 521095003925 dimer interface [polypeptide binding]; other site 521095003926 active site 521095003927 metal binding site [ion binding]; metal-binding site 521095003928 EDD domain protein, DegV family; Region: DegV; TIGR00762 521095003929 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 521095003930 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 521095003931 EamA-like transporter family; Region: EamA; pfam00892 521095003932 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 521095003933 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095003934 FeS/SAM binding site; other site 521095003935 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 521095003936 ATP cone domain; Region: ATP-cone; pfam03477 521095003937 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 521095003938 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 521095003939 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521095003940 active site 521095003941 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 521095003942 active site 521095003943 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521095003944 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 521095003945 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 521095003946 dimerization interface 3.5A [polypeptide binding]; other site 521095003947 active site 521095003948 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 521095003949 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095003950 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521095003951 Walker A/P-loop; other site 521095003952 ATP binding site [chemical binding]; other site 521095003953 Q-loop/lid; other site 521095003954 ABC transporter signature motif; other site 521095003955 Walker B; other site 521095003956 D-loop; other site 521095003957 H-loop/switch region; other site 521095003958 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 521095003959 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 521095003960 Walker A/P-loop; other site 521095003961 ATP binding site [chemical binding]; other site 521095003962 Q-loop/lid; other site 521095003963 ABC transporter signature motif; other site 521095003964 Walker B; other site 521095003965 D-loop; other site 521095003966 H-loop/switch region; other site 521095003967 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 521095003968 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 521095003969 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 521095003970 alphaNTD homodimer interface [polypeptide binding]; other site 521095003971 alphaNTD - beta interaction site [polypeptide binding]; other site 521095003972 alphaNTD - beta' interaction site [polypeptide binding]; other site 521095003973 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 521095003974 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 521095003975 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 521095003976 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 521095003977 RNA binding surface [nucleotide binding]; other site 521095003978 30S ribosomal protein S11; Validated; Region: PRK05309 521095003979 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 521095003980 30S ribosomal protein S13; Region: bact_S13; TIGR03631 521095003981 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 521095003982 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 521095003983 rRNA binding site [nucleotide binding]; other site 521095003984 predicted 30S ribosome binding site; other site 521095003985 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 521095003986 active site 521095003987 adenylate kinase; Reviewed; Region: adk; PRK00279 521095003988 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 521095003989 AMP-binding site [chemical binding]; other site 521095003990 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 521095003991 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 521095003992 SecY translocase; Region: SecY; pfam00344 521095003993 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 521095003994 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 521095003995 23S rRNA binding site [nucleotide binding]; other site 521095003996 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 521095003997 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 521095003998 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 521095003999 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 521095004000 5S rRNA interface [nucleotide binding]; other site 521095004001 L27 interface [polypeptide binding]; other site 521095004002 23S rRNA interface [nucleotide binding]; other site 521095004003 L5 interface [polypeptide binding]; other site 521095004004 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 521095004005 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521095004006 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 521095004007 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 521095004008 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 521095004009 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 521095004010 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 521095004011 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 521095004012 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 521095004013 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 521095004014 RNA binding site [nucleotide binding]; other site 521095004015 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 521095004016 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 521095004017 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 521095004018 23S rRNA interface [nucleotide binding]; other site 521095004019 putative translocon interaction site; other site 521095004020 signal recognition particle (SRP54) interaction site; other site 521095004021 L23 interface [polypeptide binding]; other site 521095004022 trigger factor interaction site; other site 521095004023 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 521095004024 23S rRNA interface [nucleotide binding]; other site 521095004025 5S rRNA interface [nucleotide binding]; other site 521095004026 putative antibiotic binding site [chemical binding]; other site 521095004027 L25 interface [polypeptide binding]; other site 521095004028 L27 interface [polypeptide binding]; other site 521095004029 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 521095004030 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 521095004031 G-X-X-G motif; other site 521095004032 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 521095004033 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 521095004034 putative translocon binding site; other site 521095004035 protein-rRNA interface [nucleotide binding]; other site 521095004036 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 521095004037 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 521095004038 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 521095004039 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 521095004040 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 521095004041 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 521095004042 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 521095004043 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 521095004044 Low molecular weight phosphatase family; Region: LMWPc; cd00115 521095004045 active site 521095004046 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 521095004047 elongation factor G; Reviewed; Region: PRK00007 521095004048 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 521095004049 G1 box; other site 521095004050 putative GEF interaction site [polypeptide binding]; other site 521095004051 GTP/Mg2+ binding site [chemical binding]; other site 521095004052 Switch I region; other site 521095004053 G2 box; other site 521095004054 G3 box; other site 521095004055 Switch II region; other site 521095004056 G4 box; other site 521095004057 G5 box; other site 521095004058 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 521095004059 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 521095004060 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 521095004061 30S ribosomal protein S7; Validated; Region: PRK05302 521095004062 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 521095004063 S17 interaction site [polypeptide binding]; other site 521095004064 S8 interaction site; other site 521095004065 16S rRNA interaction site [nucleotide binding]; other site 521095004066 streptomycin interaction site [chemical binding]; other site 521095004067 23S rRNA interaction site [nucleotide binding]; other site 521095004068 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 521095004069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521095004070 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 521095004071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 521095004072 Coenzyme A binding pocket [chemical binding]; other site 521095004073 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 521095004074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 521095004075 dimerization interface [polypeptide binding]; other site 521095004076 putative DNA binding site [nucleotide binding]; other site 521095004077 putative Zn2+ binding site [ion binding]; other site 521095004078 DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906 521095004079 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 521095004080 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 521095004081 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 521095004082 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 521095004083 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 521095004084 cleft; other site 521095004085 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 521095004086 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 521095004087 DNA binding site [nucleotide binding] 521095004088 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 521095004089 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 521095004090 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 521095004091 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521095004092 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 521095004093 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 521095004094 RPB1 interaction site [polypeptide binding]; other site 521095004095 RPB10 interaction site [polypeptide binding]; other site 521095004096 RPB11 interaction site [polypeptide binding]; other site 521095004097 RPB3 interaction site [polypeptide binding]; other site 521095004098 RPB12 interaction site [polypeptide binding]; other site 521095004099 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 521095004100 peripheral dimer interface [polypeptide binding]; other site 521095004101 core dimer interface [polypeptide binding]; other site 521095004102 L10 interface [polypeptide binding]; other site 521095004103 L11 interface [polypeptide binding]; other site 521095004104 putative EF-Tu interaction site [polypeptide binding]; other site 521095004105 putative EF-G interaction site [polypeptide binding]; other site 521095004106 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 521095004107 23S rRNA interface [nucleotide binding]; other site 521095004108 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 521095004109 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 521095004110 mRNA/rRNA interface [nucleotide binding]; other site 521095004111 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 521095004112 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 521095004113 23S rRNA interface [nucleotide binding]; other site 521095004114 L7/L12 interface [polypeptide binding]; other site 521095004115 putative thiostrepton binding site; other site 521095004116 L25 interface [polypeptide binding]; other site 521095004117 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 521095004118 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 521095004119 putative homodimer interface [polypeptide binding]; other site 521095004120 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 521095004121 heterodimer interface [polypeptide binding]; other site 521095004122 homodimer interface [polypeptide binding]; other site 521095004123 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 521095004124 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 521095004125 elongation factor Tu; Reviewed; Region: PRK00049 521095004126 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 521095004127 G1 box; other site 521095004128 GEF interaction site [polypeptide binding]; other site 521095004129 GTP/Mg2+ binding site [chemical binding]; other site 521095004130 Switch I region; other site 521095004131 G2 box; other site 521095004132 G3 box; other site 521095004133 Switch II region; other site 521095004134 G4 box; other site 521095004135 G5 box; other site 521095004136 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 521095004137 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 521095004138 Antibiotic Binding Site [chemical binding]; other site 521095004139 YacP-like NYN domain; Region: NYN_YacP; pfam05991 521095004140 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 521095004141 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 521095004142 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 521095004143 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 521095004144 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 521095004145 active site 521095004146 HIGH motif; other site 521095004147 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 521095004148 KMSKS motif; other site 521095004149 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 521095004150 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 521095004151 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 521095004152 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 521095004153 Walker A/P-loop; other site 521095004154 ATP binding site [chemical binding]; other site 521095004155 Q-loop/lid; other site 521095004156 ABC transporter signature motif; other site 521095004157 Walker B; other site 521095004158 D-loop; other site 521095004159 H-loop/switch region; other site 521095004160 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 521095004161 homotrimer interaction site [polypeptide binding]; other site 521095004162 zinc binding site [ion binding]; other site 521095004163 CDP-binding sites; other site 521095004164 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 521095004165 substrate binding site; other site 521095004166 dimer interface; other site 521095004167 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 521095004168 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 521095004169 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 521095004170 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 521095004171 Clp amino terminal domain; Region: Clp_N; pfam02861 521095004172 Clp amino terminal domain; Region: Clp_N; pfam02861 521095004173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095004174 Walker A motif; other site 521095004175 ATP binding site [chemical binding]; other site 521095004176 Walker B motif; other site 521095004177 arginine finger; other site 521095004178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095004179 Walker A motif; other site 521095004180 ATP binding site [chemical binding]; other site 521095004181 Walker B motif; other site 521095004182 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 521095004183 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 521095004184 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 521095004185 dimer interface [polypeptide binding]; other site 521095004186 putative anticodon binding site; other site 521095004187 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 521095004188 motif 1; other site 521095004189 active site 521095004190 motif 2; other site 521095004191 motif 3; other site 521095004192 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 521095004193 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 521095004194 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 521095004195 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 521095004196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521095004197 malate dehydrogenase; Provisional; Region: PRK13529 521095004198 Malic enzyme, N-terminal domain; Region: malic; pfam00390 521095004199 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 521095004200 NAD(P) binding site [chemical binding]; other site 521095004201 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 521095004202 active site 521095004203 tetramer interface [polypeptide binding]; other site 521095004204 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 521095004205 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 521095004206 substrate binding site [chemical binding]; other site 521095004207 dimer interface [polypeptide binding]; other site 521095004208 ATP binding site [chemical binding]; other site 521095004209 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 521095004210 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 521095004211 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 521095004212 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 521095004213 Soluble P-type ATPase [General function prediction only]; Region: COG4087 521095004214 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 521095004215 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 521095004216 FMN binding site [chemical binding]; other site 521095004217 dimer interface [polypeptide binding]; other site 521095004218 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 521095004219 dimer interface [polypeptide binding]; other site 521095004220 FMN binding site [chemical binding]; other site 521095004221 Uncharacterized conserved protein [Function unknown]; Region: COG3589 521095004222 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 521095004223 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 521095004224 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521095004225 active site turn [active] 521095004226 phosphorylation site [posttranslational modification] 521095004227 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 521095004228 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 521095004229 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 521095004230 putative active site [active] 521095004231 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 521095004232 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 521095004233 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 521095004234 putative active site [active] 521095004235 Beta-lactamase; Region: Beta-lactamase; cl17358 521095004236 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 521095004237 Predicted flavoprotein [General function prediction only]; Region: COG0431 521095004238 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 521095004239 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 521095004240 GAF domain; Region: GAF_2; pfam13185 521095004241 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 521095004242 dimer interface [polypeptide binding]; other site 521095004243 active site 521095004244 metal binding site [ion binding]; metal-binding site 521095004245 glutathione binding site [chemical binding]; other site 521095004246 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 521095004247 oligoendopeptidase F; Region: pepF; TIGR00181 521095004248 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 521095004249 active site 521095004250 Zn binding site [ion binding]; other site 521095004251 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 521095004252 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 521095004253 gating phenylalanine in ion channel; other site 521095004254 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 521095004255 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 521095004256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 521095004257 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 521095004258 Walker A motif; other site 521095004259 ATP binding site [chemical binding]; other site 521095004260 Walker B motif; other site 521095004261 arginine finger; other site 521095004262 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 521095004263 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 521095004264 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 521095004265 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 521095004266 putative phosphoketolase; Provisional; Region: PRK05261 521095004267 XFP N-terminal domain; Region: XFP_N; pfam09364 521095004268 XFP C-terminal domain; Region: XFP_C; pfam09363 521095004269 Transcriptional regulators [Transcription]; Region: PurR; COG1609 521095004270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 521095004271 DNA binding site [nucleotide binding] 521095004272 domain linker motif; other site 521095004273 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 521095004274 dimerization interface [polypeptide binding]; other site 521095004275 ligand binding site [chemical binding]; other site 521095004276 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 521095004277 Helix-turn-helix domain; Region: HTH_17; cl17695 521095004278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095004279 sequence-specific DNA binding site [nucleotide binding]; other site 521095004280 salt bridge; other site 521095004281 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 521095004282 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 521095004283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 521095004284 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 521095004285 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 521095004286 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 521095004287 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 521095004288 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 521095004289 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 521095004290 tetramer interface [polypeptide binding]; other site 521095004291 catalytic Zn binding site [ion binding]; other site 521095004292 NADP binding site [chemical binding]; other site 521095004293 Uncharacterized conserved protein [Function unknown]; Region: COG1434 521095004294 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 521095004295 putative active site [active] 521095004296 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 521095004297 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 521095004298 TM2 domain; Region: TM2; pfam05154 521095004299 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521095004300 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 521095004301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521095004302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521095004303 dimer interface [polypeptide binding]; other site 521095004304 phosphorylation site [posttranslational modification] 521095004305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095004306 ATP binding site [chemical binding]; other site 521095004307 Mg2+ binding site [ion binding]; other site 521095004308 G-X-G motif; other site 521095004309 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521095004310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095004311 active site 521095004312 phosphorylation site [posttranslational modification] 521095004313 intermolecular recognition site; other site 521095004314 dimerization interface [polypeptide binding]; other site 521095004315 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095004316 DNA binding site [nucleotide binding] 521095004317 transcriptional repressor DicA; Reviewed; Region: PRK09706 521095004318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095004319 non-specific DNA binding site [nucleotide binding]; other site 521095004320 salt bridge; other site 521095004321 sequence-specific DNA binding site [nucleotide binding]; other site 521095004322 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 521095004323 Isochorismatase family; Region: Isochorismatase; pfam00857 521095004324 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 521095004325 catalytic triad [active] 521095004326 conserved cis-peptide bond; other site 521095004327 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 521095004328 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 521095004329 Fe-S cluster binding site [ion binding]; other site 521095004330 active site 521095004331 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 521095004332 alanine racemase; Reviewed; Region: alr; PRK00053 521095004333 active site 521095004334 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 521095004335 dimer interface [polypeptide binding]; other site 521095004336 substrate binding site [chemical binding]; other site 521095004337 catalytic residues [active] 521095004338 Uncharacterized conserved protein [Function unknown]; Region: COG0062 521095004339 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 521095004340 putative substrate binding site [chemical binding]; other site 521095004341 putative ATP binding site [chemical binding]; other site 521095004342 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 521095004343 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 521095004344 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 521095004345 active site 521095004346 substrate binding site [chemical binding]; other site 521095004347 metal binding site [ion binding]; metal-binding site 521095004348 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 521095004349 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 521095004350 23S rRNA interface [nucleotide binding]; other site 521095004351 L3 interface [polypeptide binding]; other site 521095004352 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 521095004353 Putative esterase; Region: Esterase; pfam00756 521095004354 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 521095004355 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 521095004356 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 521095004357 putative substrate binding site [chemical binding]; other site 521095004358 putative ATP binding site [chemical binding]; other site 521095004359 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 521095004360 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 521095004361 active site 521095004362 nucleophile elbow; other site 521095004363 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 521095004364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 521095004365 non-specific DNA binding site [nucleotide binding]; other site 521095004366 salt bridge; other site 521095004367 sequence-specific DNA binding site [nucleotide binding]; other site 521095004368 Uncharacterized conserved protein [Function unknown]; Region: COG3589 521095004369 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 521095004370 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 521095004371 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 521095004372 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 521095004373 active site 521095004374 P-loop; other site 521095004375 phosphorylation site [posttranslational modification] 521095004376 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 521095004377 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 521095004378 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 521095004379 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 521095004380 substrate binding [chemical binding]; other site 521095004381 active site 521095004382 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 521095004383 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 521095004384 Bacterial Ig-like domain 2; Region: BID_2; smart00635 521095004385 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 521095004386 G5 domain; Region: G5; pfam07501 521095004387 Protein of unknown function (DUF805); Region: DUF805; cl01224 521095004388 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 521095004389 LytTr DNA-binding domain; Region: LytTR; smart00850 521095004390 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 521095004391 active site 521095004392 catalytic site [active] 521095004393 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 521095004394 Cna protein B-type domain; Region: Cna_B; pfam05738 521095004395 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 521095004396 metal ion-dependent adhesion site (MIDAS); other site 521095004397 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 521095004398 Cna protein B-type domain; Region: Cna_B; pfam05738 521095004399 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 521095004400 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 521095004401 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 521095004402 Predicted transcriptional regulators [Transcription]; Region: COG1695 521095004403 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 521095004404 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 521095004405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095004406 S-adenosylmethionine binding site [chemical binding]; other site 521095004407 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 521095004408 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 521095004409 Rubredoxin; Region: Rubredoxin; pfam00301 521095004410 iron binding site [ion binding]; other site 521095004411 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 521095004412 SmpB-tmRNA interface; other site 521095004413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 521095004414 TPR motif; other site 521095004415 binding surface 521095004416 VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358 521095004417 RNB domain; Region: RNB; pfam00773 521095004418 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 521095004419 RNA binding site [nucleotide binding]; other site 521095004420 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 521095004421 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 521095004422 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 521095004423 active site 521095004424 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 521095004425 Transcriptional regulator [Transcription]; Region: LysR; COG0583 521095004426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 521095004427 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 521095004428 dimerization interface [polypeptide binding]; other site 521095004429 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 521095004430 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 521095004431 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 521095004432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 521095004433 Walker A/P-loop; other site 521095004434 ATP binding site [chemical binding]; other site 521095004435 Q-loop/lid; other site 521095004436 ABC transporter signature motif; other site 521095004437 Walker B; other site 521095004438 D-loop; other site 521095004439 H-loop/switch region; other site 521095004440 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 521095004441 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 521095004442 active site 521095004443 intersubunit interface [polypeptide binding]; other site 521095004444 catalytic residue [active] 521095004445 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 521095004446 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 521095004447 inhibitor site; inhibition site 521095004448 active site 521095004449 dimer interface [polypeptide binding]; other site 521095004450 catalytic residue [active] 521095004451 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 521095004452 putative active site [active] 521095004453 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 521095004454 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 521095004455 active site 521095004456 P-loop; other site 521095004457 phosphorylation site [posttranslational modification] 521095004458 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 521095004459 active site 521095004460 phosphorylation site [posttranslational modification] 521095004461 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 521095004462 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 521095004463 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 521095004464 Uncharacterized conserved protein [Function unknown]; Region: COG1284 521095004465 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521095004466 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 521095004467 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 521095004468 peptide chain release factor 2; Validated; Region: prfB; PRK00578 521095004469 PCRF domain; Region: PCRF; pfam03462 521095004470 RF-1 domain; Region: RF-1; pfam00472 521095004471 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 521095004472 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 521095004473 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 521095004474 nucleotide binding region [chemical binding]; other site 521095004475 SEC-C motif; Region: SEC-C; pfam02810 521095004476 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 521095004477 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 521095004478 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 521095004479 active site 521095004480 substrate binding site [chemical binding]; other site 521095004481 metal binding site [ion binding]; metal-binding site 521095004482 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 521095004483 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 521095004484 active site 521095004485 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 521095004486 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 521095004487 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 521095004488 Transcriptional regulator [Transcription]; Region: LytR; COG1316 521095004489 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 521095004490 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 521095004491 hinge; other site 521095004492 active site 521095004493 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 521095004494 gamma subunit interface [polypeptide binding]; other site 521095004495 LBP interface [polypeptide binding]; other site 521095004496 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 521095004497 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521095004498 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 521095004499 alpha subunit interaction interface [polypeptide binding]; other site 521095004500 Walker A motif; other site 521095004501 ATP binding site [chemical binding]; other site 521095004502 Walker B motif; other site 521095004503 inhibitor binding site; inhibition site 521095004504 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 521095004505 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 521095004506 core domain interface [polypeptide binding]; other site 521095004507 delta subunit interface [polypeptide binding]; other site 521095004508 epsilon subunit interface [polypeptide binding]; other site 521095004509 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 521095004510 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 521095004511 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 521095004512 beta subunit interaction interface [polypeptide binding]; other site 521095004513 Walker A motif; other site 521095004514 ATP binding site [chemical binding]; other site 521095004515 Walker B motif; other site 521095004516 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 521095004517 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 521095004518 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 521095004519 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 521095004520 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 521095004521 ATP synthase subunit C; Region: ATP-synt_C; cl00466 521095004522 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 521095004523 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 521095004524 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 521095004525 active site 521095004526 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 521095004527 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 521095004528 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 521095004529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 521095004530 S-adenosylmethionine binding site [chemical binding]; other site 521095004531 peptide chain release factor 1; Validated; Region: prfA; PRK00591 521095004532 This domain is found in peptide chain release factors; Region: PCRF; smart00937 521095004533 RF-1 domain; Region: RF-1; pfam00472 521095004534 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 521095004535 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 521095004536 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 521095004537 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 521095004538 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 521095004539 active site 521095004540 phosphorylation site [posttranslational modification] 521095004541 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 521095004542 active pocket/dimerization site; other site 521095004543 active site 521095004544 phosphorylation site [posttranslational modification] 521095004545 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 521095004546 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 521095004547 active site 521095004548 dimer interface [polypeptide binding]; other site 521095004549 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 521095004550 dimer interface [polypeptide binding]; other site 521095004551 active site 521095004552 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 521095004553 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 521095004554 catalytic residues [active] 521095004555 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 521095004556 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 521095004557 active site 521095004558 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 521095004559 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 521095004560 active site 521095004561 metal binding site [ion binding]; metal-binding site 521095004562 homotetramer interface [polypeptide binding]; other site 521095004563 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 521095004564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095004565 active site 521095004566 phosphorylation site [posttranslational modification] 521095004567 intermolecular recognition site; other site 521095004568 dimerization interface [polypeptide binding]; other site 521095004569 LytTr DNA-binding domain; Region: LytTR; smart00850 521095004570 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 521095004571 Histidine kinase; Region: His_kinase; pfam06580 521095004572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095004573 ATP binding site [chemical binding]; other site 521095004574 Mg2+ binding site [ion binding]; other site 521095004575 G-X-G motif; other site 521095004576 QueT transporter; Region: QueT; pfam06177 521095004577 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 521095004578 conserved cys residue [active] 521095004579 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 521095004580 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 521095004581 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 521095004582 dimer interface [polypeptide binding]; other site 521095004583 PYR/PP interface [polypeptide binding]; other site 521095004584 TPP binding site [chemical binding]; other site 521095004585 substrate binding site [chemical binding]; other site 521095004586 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 521095004587 Domain of unknown function; Region: EKR; pfam10371 521095004588 4Fe-4S binding domain; Region: Fer4_6; pfam12837 521095004589 4Fe-4S binding domain; Region: Fer4; pfam00037 521095004590 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 521095004591 TPP-binding site [chemical binding]; other site 521095004592 dimer interface [polypeptide binding]; other site 521095004593 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 521095004594 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 521095004595 purine monophosphate binding site [chemical binding]; other site 521095004596 dimer interface [polypeptide binding]; other site 521095004597 putative catalytic residues [active] 521095004598 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 521095004599 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 521095004600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 521095004601 Coenzyme A binding pocket [chemical binding]; other site 521095004602 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 521095004603 active site 521095004604 HIGH motif; other site 521095004605 nucleotide binding site [chemical binding]; other site 521095004606 active site 521095004607 KMSKS motif; other site 521095004608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 521095004609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521095004610 dimer interface [polypeptide binding]; other site 521095004611 phosphorylation site [posttranslational modification] 521095004612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095004613 ATP binding site [chemical binding]; other site 521095004614 Mg2+ binding site [ion binding]; other site 521095004615 G-X-G motif; other site 521095004616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 521095004617 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 521095004618 DNA-binding site [nucleotide binding]; DNA binding site 521095004619 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 521095004620 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 521095004621 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 521095004622 active site turn [active] 521095004623 phosphorylation site [posttranslational modification] 521095004624 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 521095004625 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 521095004626 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 521095004627 Ca binding site [ion binding]; other site 521095004628 active site 521095004629 catalytic site [active] 521095004630 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 521095004631 seryl-tRNA synthetase; Provisional; Region: PRK05431 521095004632 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 521095004633 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 521095004634 dimer interface [polypeptide binding]; other site 521095004635 active site 521095004636 motif 1; other site 521095004637 motif 2; other site 521095004638 motif 3; other site 521095004639 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521095004640 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521095004641 active site 521095004642 ATP binding site [chemical binding]; other site 521095004643 substrate binding site [chemical binding]; other site 521095004644 activation loop (A-loop); other site 521095004645 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 521095004646 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521095004647 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521095004648 phosphopeptide binding site; other site 521095004649 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 521095004650 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 521095004651 phosphopeptide binding site; other site 521095004652 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 521095004653 active site 521095004654 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 521095004655 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 521095004656 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 521095004657 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 521095004658 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 521095004659 Catalytic domain of Protein Kinases; Region: PKc; cd00180 521095004660 active site 521095004661 ATP binding site [chemical binding]; other site 521095004662 substrate binding site [chemical binding]; other site 521095004663 activation loop (A-loop); other site 521095004664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 521095004665 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521095004666 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521095004667 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521095004668 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 521095004669 Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277 521095004670 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 521095004671 active site 521095004672 ATP binding site [chemical binding]; other site 521095004673 substrate binding site [chemical binding]; other site 521095004674 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 521095004675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 521095004676 dimerization interface [polypeptide binding]; other site 521095004677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 521095004678 dimer interface [polypeptide binding]; other site 521095004679 phosphorylation site [posttranslational modification] 521095004680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 521095004681 ATP binding site [chemical binding]; other site 521095004682 Mg2+ binding site [ion binding]; other site 521095004683 G-X-G motif; other site 521095004684 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 521095004685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 521095004686 active site 521095004687 phosphorylation site [posttranslational modification] 521095004688 intermolecular recognition site; other site 521095004689 dimerization interface [polypeptide binding]; other site 521095004690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 521095004691 DNA binding site [nucleotide binding] 521095004692 adenylosuccinate lyase; Provisional; Region: PRK07492 521095004693 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 521095004694 tetramer interface [polypeptide binding]; other site 521095004695 active site 521095004696 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 521095004697 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 521095004698 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 521095004699 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 521095004700 metal binding site 2 [ion binding]; metal-binding site 521095004701 putative DNA binding helix; other site 521095004702 metal binding site 1 [ion binding]; metal-binding site 521095004703 dimer interface [polypeptide binding]; other site 521095004704 structural Zn2+ binding site [ion binding]; other site 521095004705 Cna protein B-type domain; Region: Cna_B; pfam05738 521095004706 Cna protein B-type domain; Region: Cna_B; pfam05738 521095004707 WYL domain; Region: WYL; pfam13280 521095004708 WYL domain; Region: WYL; pfam13280 521095004709 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 521095004710 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 521095004711 active site 521095004712 catalytic site [active] 521095004713 substrate binding site [chemical binding]; other site 521095004714 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 521095004715 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 521095004716 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 521095004717 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 521095004718 ATP-grasp domain; Region: ATP-grasp_4; cl17255 521095004719 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 521095004720 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 521095004721 FeS/SAM binding site; other site 521095004722 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 521095004723 ParB-like nuclease domain; Region: ParB; smart00470 521095004724 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 521095004725 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521095004726 P-loop; other site 521095004727 Magnesium ion binding site [ion binding]; other site 521095004728 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 521095004729 Magnesium ion binding site [ion binding]; other site 521095004730 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 521095004731 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 521095004732 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 521095004733 G-X-X-G motif; other site 521095004734 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 521095004735 RxxxH motif; other site 521095004736 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 521095004737 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 521095004738 Haemolytic domain; Region: Haemolytic; pfam01809 521095004739 Ribonuclease P; Region: Ribonuclease_P; pfam00825 521095004740 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399