-- dump date 20140618_210038 -- class Genbank::CDS -- table cds_note -- id note YP_001522917.1 DUF299 YP_001522921.1 DNA polymerase 3, epsilon subunit YP_001522924.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001522926.1 UPF0054 YP_001522927.1 with CBS domain YP_001522928.1 Transfers the fatty acyl group on membrane lipoproteins YP_001522929.1 helix-turn-helix motif YP_001522931.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001522932.1 LysR family YP_001522933.1 conserved in bacteria YP_001522934.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001522935.1 DUF448 YP_001522936.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001522937.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001522939.1 periplasmic binding protein component precursor YP_001522941.1 nucleotide binding/ATPase YP_001522943.1 cystathionine beta-synthase family protein YP_001522944.1 MarR family YP_001522946.1 possibly involved in aromatic compounds catabolism YP_001522947.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the proteins from this group do not and in addition appear to have a truncated C-terminal domain YP_001522951.1 involved in polysaccharide export YP_001522954.1 reductase SDR YP_001522971.1 tetratricopeptide region YP_001522975.1 hypoxia induced protein conserved region YP_001522976.1 major facilitator superfamily MFS_1 YP_001522980.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001522986.1 HPA2 and related acetyltransferase YP_001522990.1 GntR family YP_001522994.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_001522995.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_001522996.1 iron-sulfur subunit YP_001522997.1 conserved in bacteria YP_001523000.1 LysR family YP_001523002.1 branched-chain amino acid transport YP_001523003.1 Lipase including active site YP_001523010.1 glutathione-dependent formaldehyde-activating GFA YP_001523012.1 possible FtsK/SpoIIIE family YP_001523014.1 FAD synthetase YP_001523015.1 subfamily IIA YP_001523017.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001523018.1 resolvase, RNase H-like fold YP_001523023.1 the major facilitator superfamily YP_001523024.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001523025.1 C-terminal:DEAD/DEAH box helicase, N-terminal YP_001523029.1 methyltransferase type 12 YP_001523030.1 NADH oxidase YP_001523035.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_001523036.1 YidE/YbjL duplication YP_001523039.1 iron-sulfur binding YP_001523041.1 ATP-binding region N-terminal YP_001523042.1 helix-turn-helix YP_001523043.1 LysR family YP_001523045.1 ATPase YP_001523046.1 N-terminal YP_001523054.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_001523057.1 histidine triad (HIT) protein YP_001523059.1 tetratricopeptide-like helical YP_001523060.1 103 YP_001523061.1 globin-like YP_001523063.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001523066.1 cytochrome c YP_001523067.1 DUF1345 YP_001523071.1 G-D-S-L precursor YP_001523072.1 catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001523078.1 bacterial and archaeal type YP_001523081.1 ATP-binding region, ATPase-like histidine kinase, HAMP region, N-terminal YP_001523082.1 consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_001523083.1 cysteine rich repeat YP_001523084.1 ATP-hydrolyzing 5-oxoprolinase YP_001523086.1 DctM subunit YP_001523087.1 DctP subunit YP_001523095.1 NAD-binding YP_001523098.1 mostly Fe transport YP_001523101.1 permease component YP_001523112.1 periplasmic component YP_001523114.1 inner membrane subunit YP_001523115.1 ATPase YP_001523117.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_001523119.1 DUF1028 YP_001523123.1 MarR family YP_001523129.1 small GTP-binding protein domain YP_001523133.1 catalytic region YP_001523136.1 tetratricopeptide-like helical YP_001523137.1 heat shock protein involved in degradation of misfolded proteins YP_001523138.1 heat shock protein involved in degradation of misfolded proteins YP_001523139.1 DUF985 YP_001523141.1 methyltransferase type 11 YP_001523142.1 TetR family YP_001523145.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_001523146.1 C-terminal YP_001523150.1 C-terminal:siroheme synthase, N- terminal YP_001523153.1 DUF1058 YP_001523156.1 ATPase component YP_001523157.1 AsnC family YP_001523158.1 family 3 precursor YP_001523162.1 LysR family YP_001523166.1 DUF72 YP_001523170.1 sensory transducer precursor YP_001523172.1 DUF125, transmembrane YP_001523173.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001523174.1 N-terminal precursor YP_001523178.1 peptidase M22 YP_001523179.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001523181.1 DUF589 YP_001523183.1 catalyzes conversion of 1-aminocyclopropane-1-carboxylate to ammonia and alpha-ketobutyrate YP_001523186.1 coenzyme F420-dependent YP_001523187.1 LysR-family YP_001523189.1 auxin efflux Carrier YP_001523191.1 DUF796 YP_001523193.1 alanine racemase, N-terminal YP_001523194.1 GGDEF YP_001523198.1 Flp/Fap pilin component YP_001523204.1 converts acetoacetate to acetone and carbon dioxide YP_001523205.1 patatin YP_001523206.1 DUF81 YP_001523209.1 DUF6, transmembrane YP_001523217.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001523218.1 twin-arginine translocation pathway signal precursor YP_001523220.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001523222.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_001523224.1 GGDEF, phosphodiesterase YP_001523226.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001523228.1 TetR/AcrR family homolog; YdeS YP_001523238.1 4TM/12TM fusion protein YP_001523239.1 TAXI family precursor YP_001523243.1 E1 component-like YP_001523244.1 DUF72 YP_001523245.1 K+ channel, pore region YP_001523247.1 GTP-binding protein TypA YP_001523250.1 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine YP_001523254.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_001523258.1 TM2 YP_001523259.1 ribosomal protein S30EA YP_001523262.1 Cupin, RmlC-type YP_001523263.1 DUF1150 YP_001523265.1 large subunit YP_001523266.1 Xylose isomerase-like TIM barrel YP_001523269.1 Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group YP_001523270.1 DUF1332 YP_001523274.1 DUF883, ElaB YP_001523275.1 in Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media YP_001523282.1 HAMP region, bacterial chemotaxis sensory transducer precursor YP_001523284.1 disulphide bond formation protein DsbB YP_001523286.1 carboxylesterase family protein YP_001523294.1 family 3 precursor YP_001523296.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine YP_001523303.1 DUF952 YP_001523306.1 carboxymuconolactone decarboxylase YP_001523307.1 family 2 YP_001523311.1 SAM (and some other nucleotide) binding motif YP_001523312.1 tyrosine specific protein phosphatase YP_001523313.1 metal-dependent phosphohydrolase, HD subdomain YP_001523315.1 CHP02301 YP_001523320.1 FMN-binding split barrel YP_001523323.1 SUA5 domain, /YciO/YrdC/YwlC YP_001523324.1 cyclin-like YP_001523326.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001523327.1 related peptidoglycan-associated (lipo)protein YP_001523331.1 DUF124 YP_001523336.1 alpha ubunit YP_001523338.1 saccharopine dehydrogenase YP_001523340.1 Cpn60/TCP-1 YP_001523341.1 10 kDa YP_001523343.1 bleomycin resistance protein/dioxygenase YP_001523344.1 MiaB/NifB YP_001523345.1 bacterial aa3 type cytochrome c oxidase subunit IV YP_001523349.1 MFS family YP_001523353.1 oligoendopeptidase-related clade 3 precursor YP_001523354.1 helix-turn-helix YP_001523355.1 peptidoglycan-binding domain 1 YP_001523356.1 DUF882, bacterial YP_001523357.1 tRNA-binding arm YP_001523358.1 DUF1244 YP_001523360.1 DUF1036 YP_001523362.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_001523366.1 DUF461 YP_001523367.1 LysR family YP_001523368.1 4-oxalocrotonate tautomerase homolog YP_001523373.1 DUF1159 YP_001523377.1 glutamate synthase is composed of subunits alpha and beta; subunit beta is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the subunit alpha, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001523380.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_001523383.1 GntR, HTH YP_001523384.1 catalyzes the formation of formyl-CoA from oxalyl-CoA YP_001523386.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA YP_001523391.1 GntR, HTH YP_001523394.1 ATP-binding protein YP_001523395.1 ATP-binding protein YP_001523402.1 thiol specific antioxidant/ Mal allergen YP_001523403.1 to be involved in C-type cytochrome biogenesis, COG4233 YP_001523404.1 DUF179 YP_001523405.1 phosphodiesterase precursor, GGDEF precursor YP_001523407.1 DUF1192 YP_001523408.1 DUF1465 YP_001523409.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001523410.1 ATP-binding protein/permease YP_001523423.1 COG3027 YP_001523424.1 type I:5-formyltetrahydrofolate cyclo-ligase YP_001523425.1 conserved in bacteria, COG1692 YP_001523429.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001523431.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001523433.1 in bacteria, COG3644 YP_001523435.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001523438.1 ExbD/TolR YP_001523448.1 catalytic region YP_001523449.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001523450.1 required for colicin V production YP_001523451.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001523453.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001523454.1 DUF172 YP_001523455.1 Txe/YoeB YP_001523460.1 quinonprotein alcohol dehydrogenase-like YP_001523461.1 lipase YP_001523463.1 required for 70S ribosome assembly YP_001523464.1 COG1738 YP_001523468.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001523469.1 MhpC, hydrolases or acyltransferase YP_001523470.1 quinone reductase and related Zn-dependent oxidoreductases YP_001523472.1 conserved in bacteria YP_001523477.1 2-dehydro-3-deoxyphosphogluconate aldolase YP_001523481.1 involved in cobalamin synthesis YP_001523482.1 related arsenite permeases YP_001523483.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001523485.1 required for the assembly and function of the DNAX complex which are required for the assembly of the subunit beta onto primed DNA YP_001523487.1 superfamily MFS_1 YP_001523488.1 LuxR:response regulator receiver YP_001523489.1 sensory transducer YP_001523496.1 LysR, substrate-binding precursor YP_001523505.1 substrate-binding protein YP_001523507.1 DUF849 YP_001523509.1 TetR family YP_001523530.1 conserved in bacteria, COG3915 YP_001523534.1 response regulator receiver YP_001523537.1 COG3143, CheZ, chemotaxis protein YP_001523543.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_001523548.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thin flagella YP_001523550.1 makes up the distal portion of the flagellar basal body rod; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_001523551.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_001523552.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; Bradyrhizobium have one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_001523553.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Bradyrhizobium have one thick flagellum and several thin flagella; the proteins in this cluster are associated with the thin flagella YP_001523555.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thin flagella YP_001523559.1 surface presentation of antigens (SPOA) protein YP_001523561.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; Bradyrhizobium have one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_001523562.1 involved in type III protein export during flagellum assembly YP_001523563.1 the hook connects flagellar basal body to the flagellar filament YP_001523564.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_001523565.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thin flagella YP_001523566.1 acts as an activator or flagellin translation and may be required for filament secretion or assembly; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_001523567.1 post-transcriptional repressor of flagellum biosynthesis; promotes degradation of fljK mRNA: Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_001523568.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_001523569.1 FliQ, with proteins FliP and FliR, forms the core of the central channel in the flagella export apparatus; Bradyrhizobium have one thick flagellum and several thin flagella; the protein in this cluster is associated with the thick flagellum YP_001523570.1 membrane protein involved in the flagellar export apparatus YP_001523571.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; Bradyrhizobium has one thick and several thin flagella; the Bradyrhizobium protein in this cluster are associated with the thin flagella YP_001523580.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_001523584.1 family 2 YP_001523588.1 LysR family YP_001523593.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001523596.1 Catalyzes the reduction of sulfite to sulfide, an essential step in the anaerobic sulfate-respiration pathway YP_001523597.1 ferredoxin-dependent assimilatory nitrite reductase YP_001523604.1 COG0412, dienelactone hydrolase and related enzymes YP_001523605.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001523606.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001523610.1 unknown function (DUF1007) YP_001523615.1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates YP_001523616.1 HAD-superfamily hydrolase subfamily IA, variant 3 YP_001523617.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001523619.1 involved in phosphonate metabolism YP_001523622.1 KpsF/GutQ family protein YP_001523623.1 catalyzes the formation of dUMP from dUTP YP_001523625.1 cysteine synthase A YP_001523626.1 ATPase-like:histidine kinase A, N-terminal YP_001523627.1 phosphotransferase related to Ser/thr protein kinases YP_001523629.1 inactivated superfamily I helicase YP_001523630.1 helicase activity based on COG assignment YP_001523633.1 involved in pathogenesis precursor YP_001523635.1 HAMP region:bacterial chemotaxis sensory transducer precursor YP_001523638.1 catalyzes the formation of acetate from pyruvate YP_001523641.1 HAMP region:bacterial chemotaxis sensory transducer precursor YP_001523642.1 HAMP region:bacterial chemotaxis sensory transducer YP_001523645.1 catalyzes the formation of pyruvate and beta-alanine from L-alanine and 3-oxopropanoate YP_001523646.1 GntR family YP_001523648.1 reductase SDR YP_001523649.1 racemase YP_001523651.1 bacterial regulatory protein, TetR YP_001523653.1 conserved in bacteria YP_001523654.1 esterase/lipase/thioesterase YP_001523655.1 peptidase aspartic, catalytic YP_001523656.1 including glyoxylases YP_001523657.1 GGDEF domain YP_001523658.1 MarR family YP_001523659.1 Bcr/CflA subfamily YP_001523660.1 galactose-binding like YP_001523661.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_001523667.1 glyoxalase/bleomycin resistance protein/dioxygenase YP_001523670.1 quinone oxidoreductases YP_001523673.1 bacterial surface antigen (D15) YP_001523675.1 Fis family YP_001523679.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide YP_001523680.1 IclR family YP_001523682.1 class IV YP_001523683.1 including glyoxylases-like YP_001523685.1 2-oxohepta-3-ene-1,7-dioic acid hydratase YP_001523703.1 hydantoinase/carbamoylase YP_001523704.1 conserved in bacteria YP_001523707.1 LysR family YP_001523709.1 succinyl-diaminopimelate desuccinylase YP_001523710.1 HAMP region:bacterial chemotaxis sensory transducer YP_001523712.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001523716.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001523718.1 isomerase YP_001523721.1 YitT family YP_001523722.1 M20/M25/M40 family protein YP_001523723.1 succinyl-diaminopimelate desuccinylase and related deacylase YP_001523729.1 LysR family YP_001523730.1 AsnC family YP_001523740.1 short-chain dehydrogenase reductase (SDR)family YP_001523742.1 GMP reductase:zinc-containing alcohol dehydrogenase superfamily YP_001523744.1 N-terminal SAM-like YP_001523767.1 cytochrome c region YP_001523771.1 virulence factor, pectin lyase fold YP_001523778.1 DUF159 YP_001523783.1 Arc-like DNA binding YP_001523787.1 helix-turn-helix motif YP_001523794.1 TrmH, group 3 YP_001523796.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001523799.1 binds directly to 23S ribosomal RNA YP_001523800.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001523801.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001523802.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001523803.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; subunit beta is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001523804.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001523819.1 trypsin family YP_001523824.1 HAMP region:bacterial chemotaxis sensory transducer YP_001523825.1 BCR, YnfA/UPF0060 family YP_001523826.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001523828.1 LysR family YP_001523829.1 NH(3)-dependent; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001523830.1 HD subdomain YP_001523836.1 sulfate ABC transporter permease CysW YP_001523837.1 sulfate ABC transporter permease CysT YP_001523838.1 periplasmic binding protein component YP_001523840.1 DUF934 YP_001523841.1 hemoprotein beta-component, ferrodoxin-like:nitrite and sulphite reductase 4Fe-4S region YP_001523843.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_001523844.1 sulfate adenylyltransferase large subunit YP_001523852.1 reductase SDR YP_001523856.1 twin-arginine translocation pathway signal precursor YP_001523858.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001523861.1 DUF37 YP_001523863.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001523872.1 family 3 YP_001523875.1 UPF0005 YP_001523880.1 related to arylsulfate sulfotransferase YP_001523881.1 LysR family YP_001523883.1 UCP014873 membrane YP_001523889.1 related surface antigens, COG3637 YP_001523891.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001523897.1 PRC-barrel domain YP_001523900.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate YP_001523901.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001523902.1 conserved in bacteria, COG4995 YP_001523904.1 related enzymes YP_001523908.1 N-terminal:methylmalonyl-CoA mutase, C-C-terminal YP_001523909.1 IclR family protein YP_001523912.1 catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA YP_001523914.1 GGDEF YP_001523916.1 hemolysin-type calcium-binding region YP_001523919.1 responsible for transport of beta-1,2-glucans from the cytoplasm to periplasm; inner membrane ABC transporter permease component; Cgt; ChvA; NdvA YP_001523924.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001523927.1 ErfK/YbiS/YcfS/YnhG YP_001523928.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001523929.1 binds the polymerase to DNA and acts as a sliding clamp YP_001523930.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001523931.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001523932.1 dehydratase family YP_001523933.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_001523934.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001523935.1 carbohydrate-binding YP_001523936.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001523942.1 sensory transducer with PAS domain YP_001523943.1 DUF7, transmembrane YP_001523944.1 DUF6, transmembrane YP_001523945.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001523946.1 MFS family YP_001523947.1 MFS family YP_001523949.1 DUF1153 YP_001523951.1 DUF269 YP_001523953.1 functions with NifE to assemble FeMo cofactor; functions in assembly of nitrogenase MoFe YP_001523954.1 functions with NifN to assemble FeMo cofactor; functions in assembly of nitrogenase MoFe YP_001523957.1 nitrogenase iron protein; nitrogenase component 2; with component 1, an molybdenum-iron protein, catalyzes the fixation of nitrogen to ammonia; nitrogen reductase provides electrons to the nitrogenase complex; in R. etli there are three essentially identical copies of nifH which are actively expressed during symbiosis YP_001523964.1 leucine rich repeat variant YP_001523966.1 alkylhydroperoxidase AhpD core YP_001523967.1 thiol specific antioxidant/ Mal allergen YP_001523974.1 PhnC, ATP-binding YP_001523977.1 TetR family YP_001523979.1 reductase SDR YP_001523980.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_001523981.1 PhzC/PhzF YP_001523984.1 multiple antibiotic resistance (MarC)-related proteins YP_001523987.1 6-pyruvoyl tetrahydropterin synthase and hypothetical protein YP_001523988.1 Radical SAM YP_001523989.1 bleomycin resistance protein/dioxygenase YP_001523991.1 MarR-family YP_001523994.1 HAMP region:bacterial chemotaxis sensory transducer YP_001523995.1 LysR family YP_001523999.1 histidine kinase, homodimeric YP_001524000.1 prolyl oligopeptidase family YP_001524004.1 involved in DNA replication initiation YP_001524006.1 DUF805 YP_001524007.1 Fe-S metabolism associated SufE YP_001524010.1 peptidoglycan-binding domain 1 YP_001524011.1 DUF1491 YP_001524014.1 DUF1214 YP_001524020.1 DNA binding YP_001524021.1 Terminase-like YP_001524022.1 the TIM-barrel fold YP_001524024.1 GntR family YP_001524025.1 HK97 YP_001524028.1 U35, phage prohead HK97 YP_001524029.1 HK97 YP_001524030.1 S1 and S6, chymotrypsin/Hap YP_001524031.1 phage phiE125 gp8 YP_001524034.1 TP901-1 YP_001524038.1 Pyrokinin YP_001524039.1 Pollen allergen Poa pIX/Phl pVI, C-terminal YP_001524040.1 2217 YP_001524042.1 NlpC/P60 YP_001524047.1 surface antigen (cell envelope biogenesis, outer membrane) YP_001524055.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001524062.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001524063.1 AsnC/Lrp family protein YP_001524065.1 LysR family YP_001524066.1 D-ala-D-ala digestion in peptidoglycan YP_001524069.1 selenocysteine-specific: small GTP-binding protein domain YP_001524071.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_001524077.1 thioredoxins YP_001524089.1 rieske family YP_001524091.1 AraC family YP_001524095.1 electron transfer flavoprotein beta-subunit YP_001524096.1 LysR family YP_001524097.1 alpha/beta hydrolase fold-1 YP_001524101.1 periplasmic glycine betaine-binding protein YP_001524104.1 CAIB/BAIF family YP_001524107.1 AsnC family YP_001524112.1 reductase SDR YP_001524119.1 conserved in bacteria YP_001524120.1 GGDEF domain YP_001524124.1 ubiquinone oxidoreductase 17.2 kD subunit YP_001524126.1 GGDEF domain YP_001524133.1 HPPK YP_001524135.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001524138.1 EAL domain YP_001524140.1 Invasion associated locus B YP_001524144.1 twin-arginine translocation pathway signal YP_001524155.1 N-terminal YP_001524160.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001524161.1 GNAT family YP_001524162.1 DUF1217 YP_001524163.1 DUF1217 YP_001524166.1 class I YP_001524169.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and subunit alphas YP_001524170.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_001524181.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; subunit beta of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001524184.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001524185.1 ArsR family YP_001524191.1 major facilitator superfamily MFS_1 YP_001524192.1 PadR-like family YP_001524193.1 reductase SDR YP_001524198.1 ferredoxin YP_001524202.1 helix-turn-helix, HxlR type YP_001524207.1 AraC family YP_001524211.1 LysR family YP_001524213.1 reductase YP_001524214.1 LysR family YP_001524220.1 alpha-beta hydrolase superfamily YP_001524221.1 related permeases YP_001524222.1 DUF900 YP_001524224.1 lysR family YP_001524226.1 conserved in bacteria YP_001524227.1 LysR-family YP_001524230.1 helix-turn-helix YP_001524231.1 reductase SDR YP_001524232.1 LysR, substrate-binding YP_001524235.1 reductase SDR YP_001524238.1 dimeric alpha-beta barrel YP_001524240.1 LysR family YP_001524243.1 AraC type YP_001524252.1 LysR family YP_001524256.1 Di-haem cytochrome c peroxidase YP_001524261.1 AraC family YP_001524265.1 DUF1275 YP_001524267.1 DSBA oxidoreductase YP_001524271.1 catalyzes the formation of acetate from pyruvate YP_001524273.1 FusE-MFP/HlyD family YP_001524277.1 nodulation protein W, and NwsB YP_001524281.1 glutamine-hydrolyzing YP_001524292.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001524294.1 TetR family YP_001524295.1 various substrate YP_001524298.1 marR family YP_001524300.1 acyltransferases YP_001524302.1 from the major facilitator YP_001524304.1 helix-turn-helix, AraC type YP_001524308.1 class I YP_001524309.1 xanthine dehydrogenase YP_001524310.1 (2Fe-2S)-binding protein YP_001524311.1 YdiU/UPF0061 family YP_001524317.1 molybdopterin-binding subunit YP_001524320.1 catalytic region YP_001524323.1 GntR-family YP_001524324.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_001524325.1 LysR family YP_001524326.1 dimeric alpha-beta barrel YP_001524336.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_001524339.1 upregulated by FixLJ/FixK under oxygen limitation; involved in regulation of genes involved in carbon and amino acid metabolism YP_001524347.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_001524357.1 Catalyzes the cycloisomerization of cis,cis-muconate YP_001524361.1 protein of the pcaQ, LysR family YP_001524362.1 catalyzes the formation of protocatechuate from 4-hydroxybenzoate YP_001524363.1 class II YP_001524364.1 TetR family YP_001524372.1 heavy metal translocating P-type ATPase, E1-E2 type YP_001524373.1 MerR family YP_001524376.1 DUF1211 YP_001524377.1 DUF541 YP_001524378.1 related to eukaryotic diacylglycerol kinase YP_001524380.1 DUF1328 YP_001524383.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine YP_001524384.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001524386.1 DUF1013 YP_001524388.1 family 2 YP_001524395.1 GNAT family YP_001524401.1 DUF1499 YP_001524405.1 major facilitator superfamily MFS_1 YP_001524406.1 reductase SDR YP_001524408.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001524410.1 heterotetrameric YP_001524412.1 heterotetrameric YP_001524413.1 helix-turn-helix, AraC type YP_001524419.1 helix-turn-helix motif YP_001524420.1 outer membrane autotransporter precursor YP_001524423.1 HlyB/MsbA family YP_001524431.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_001524433.1 GntR, HTH YP_001524434.1 SAM (and some other nucleotide) binding motif YP_001524438.1 dehydratase YP_001524439.1 catalyzes the hydrolysis of allophanate YP_001524441.1 molybdopterin binding YP_001524446.1 ParB-like nuclease YP_001524447.1 carnithine racemase YP_001524450.1 peptidase C15 YP_001524451.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transporters, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins YP_001524453.1 peptidase M, neutral zinc metallopeptidases, zinc-binding site YP_001524456.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate YP_001524459.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001524464.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_001524465.1 ATP-binding protein, C-terminal YP_001524467.1 ATP-binding protein, C-terminal YP_001524474.1 glycosyl transferase, family 2 YP_001524481.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001524485.1 transcriptional regulatory protein, C-terminal YP_001524488.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_001524496.1 family 39 YP_001524497.1 PA-phosphatase related YP_001524498.1 family 2 YP_001524501.1 family 3 precursor YP_001524503.1 3-TM region, His/Glu/Gln/Arg/opine YP_001524505.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001524507.1 N-terminal YP_001524512.1 including N-acetylases of ribosomal proteins YP_001524514.1 component I YP_001524515.1 AzlC-like YP_001524520.1 twin-arginine translocation pathway signal YP_001524522.1 substrate-binding LysR YP_001524523.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001524525.1 binds and unfolds substrates as part of the ClpXP protease YP_001524526.1 peptidase S16 YP_001524528.1 esterase/lipase/thioesterase YP_001524530.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001524533.1 ferritin/ribonucleotide reductase-like YP_001524539.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_001524540.1 periplasmic siderophore binding protein YP_001524541.1 ATP-binding protein YP_001524544.1 AAA+ superfamily YP_001524547.1 2-oxohepta-3-ene-1,7-dioic acid hydratase YP_001524552.1 GntR family YP_001524561.1 class III YP_001524563.1 DUF6, transmembrane YP_001524567.1 conserved in bacteria YP_001524568.1 ATPase-like HAMP YP_001524569.1 helix-turn-helix YP_001524573.1 family UPF0066 YP_001524574.1 beta-ketoacyl synthase YP_001524575.1 DUF697 YP_001524579.1 MltA-interacting YP_001524580.1 prokaryotic DksA/TraR C4 type YP_001524584.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001524587.1 ubiquinone, 24 kDa subunit YP_001524588.1 part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_001524589.1 pentapeptide repeat YP_001524590.1 Catalyzes the transfer of electrons from NADH to quinone YP_001524591.1 Catalyzes the transfer of electrons from NADH to quinone YP_001524592.1 Catalyzes the transfer of electrons from NADH to quinone YP_001524597.1 Catalyzes the transfer of electrons from NADH to quinone YP_001524601.1 DUF1467 YP_001524602.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001524603.1 LolC/E family YP_001524607.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001524609.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001524610.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001524611.1 Catalyzes the phosphorylation of UMP to UDP YP_001524612.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001524615.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001524616.1 peptidase M50 YP_001524618.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001524619.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001524621.1 DUF1009 YP_001524622.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_001524628.1 family 2 precursor YP_001524633.1 TonB, C-terminal YP_001524634.1 UDP-N-acetylglucosamine pyrophosphorylase YP_001524635.1 isomerising YP_001524637.1 HAMP region:bacterial chemotaxis sensory YP_001524640.1 conserved in bacteria YP_001524641.1 C-terminal:DEAD/DEAH box helicase, N-terminal YP_001524642.1 ErfK/YbiS/YcfS/YnhG YP_001524646.1 DUF900, hydrolase-like YP_001524652.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001524655.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001524657.1 pyruvate dehydrogenase E1 component subunit alpha YP_001524659.1 catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acetyltransferase within the complex. The E1 component of the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase(E2) and lipoamide dehydrogenase YP_001524660.1 dihydrolipoamide acetyltransferase; long form YP_001524661.1 conserved in bacteria YP_001524662.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001524663.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001524664.1 Streptomyces cyclase/dehydrase YP_001524665.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001524666.1 transporters with 2 CBS domains YP_001524668.1 virulence factor, pectin lyase fold YP_001524673.1 family 2 YP_001524674.1 branched-chain amino acid uptake protein YP_001524675.1 ABC transporter substrate-binding protein precursor YP_001524680.1 urease, subunit gamma region YP_001524681.1 GFA YP_001524682.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_001524686.1 DUF938 YP_001524687.1 beta-lactamase-like YP_001524688.1 MDM; functions in conversion of succinate to propionate YP_001524689.1 small subunit YP_001524692.1 helix-turn-helix motif YP_001524694.1 with a bacterial SH3 domain precursor YP_001524700.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001524701.1 aminotransferase, class-II YP_001524702.1 homocitrate synthase YP_001524707.1 N-terminal:molybdenum-pterin binding protein YP_001524721.1 LysR family YP_001524724.1 isomerase YP_001524730.1 DUF201 YP_001524731.1 involved in cell-cycle regulation YP_001524733.1 in bacteria (DUF403) YP_001524739.1 universal stress protein (Usp) YP_001524740.1 E1-E2 type YP_001524743.1 helix-turn-helix motif YP_001524746.1 HAD-superfamily hydrolase subfamily IIIA YP_001524747.1 OAC3 (Azorhizobium caulinodans) YP_001524748.1 OAC2 (Azorhizobium caulinodans) YP_001524749.1 OAC1 (Azorhizobium caulinodans) YP_001524756.1 alpha/beta hydrolase fold-1 YP_001524758.1 carnitine dehydratase YP_001524759.1 involved in ubiquinone/menaquinone biosynthesis YP_001524764.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_001524765.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001524768.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001524771.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001524773.1 NUDIX hydrolase YP_001524774.1 protein conserved in bacteria YP_001524775.1 VacB and RNase II YP_001524776.1 major facilitator superfamily YP_001524777.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001524779.1 TetR family YP_001524780.1 Ion transporter YP_001524781.1 Converts isocitrate to alpha ketoglutarate YP_001524782.1 quinonprotein alcohol dehydrogenase-like protein YP_001524783.1 TrmH, group 1 YP_001524789.1 substrate-binding LysR YP_001524791.1 carnitine dehydratase YP_001524796.1 Bleomycin resistance protein/dioxygenase superfamily YP_001524804.1 related Zn-dependent oxidoreductase YP_001524805.1 family 2 YP_001524811.1 LysR family YP_001524815.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_001524816.1 Cupin region YP_001524817.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001524823.1 dihydrolipoamide acetyltransferase YP_001524827.1 helix-turn-helix, Fis-type YP_001524828.1 propeptide YP_001524831.1 with a C-terminal OMP (outer membrane protein) domain COG4625 YP_001524832.1 DUF779 YP_001524834.1 Fis-type YP_001524836.1 COG1917, contains double-stranded beta-helix domain YP_001524837.1 involved in heme utilization or adhesion protein YP_001524844.1 LysR-family YP_001524853.1 COG1430 YP_001524857.1 ATPase-like:histidine kinase A, N-terminal YP_001524863.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_001524864.1 the major facilitator superfamily YP_001524865.1 LysR family YP_001524869.1 transcriptional regulatory protein, C-terminal YP_001524870.1 ATPase-like:histidine kinase A, N-terminal YP_001524879.1 catalyzes the transamination of D-amino acids and their alpha-keto acids YP_001524880.1 LysR-family YP_001524882.1 catalyzes the hydrolytic cleavage of imides that range from linear to heterocyclic and that include hydantoins, dihydropyrimidines, and phthalimides YP_001524883.1 GntR family YP_001524890.1 GntR family YP_001524892.1 BNR repeat YP_001524903.1 peptidase M20D YP_001524909.1 GntR family YP_001524913.1 LysR family YP_001524914.1 UbiH/UbiF/VisC/COQ6 YP_001524915.1 zinc-containing alcohol dehydrogenase superfamily YP_001524917.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_001524918.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001524919.1 peptidase S26A YP_001524921.1 small GTP-binding protein domain:GTP-binding protein Era YP_001524923.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001524925.1 adducin YP_001524932.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_001524941.1 AsnC family YP_001524946.1 subfamily IA YP_001524953.1 DUF861 YP_001524957.1 LysR family YP_001524959.1 GntR family YP_001524960.1 adducin, N-terminal YP_001524966.1 reductase SDR YP_001524967.1 LysR family YP_001524971.1 DUF893 YP_001524975.1 RimL YP_001524977.1 reductase SDR YP_001524978.1 AMP-dependent ligase YP_001524982.1 catalyzes the oxidative deamination of D-amino acids YP_001524983.1 Lrp family YP_001524984.1 LysE family YP_001524988.1 signal transduction systems, periplasmic component/domain YP_001524990.1 catalyzes the release of C-terminal glutamate residues from N-acylating moieties YP_001524991.1 peptidase M20D YP_001524997.1 DUF81 YP_001525002.1 ArsR family YP_001525004.1 related to 2-nitropropane dioxygenase YP_001525005.1 conserved in bacteria, COG4529 YP_001525006.1 DeoR family YP_001525020.1 Fis family YP_001525021.1 succinate dehydrogenase flavoprotein-like YP_001525022.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001525024.1 GntR family YP_001525037.1 esterase/lipase/thioesterase YP_001525038.1 inactivated derivatives-like YP_001525039.1 insertion sequence YP_001525043.1 helix-turn-helix, Fis-type YP_001525044.1 prophage MuMc02 YP_001525045.1 prophage MuMc02 YP_001525046.1 Winged helix repressor DNA-binding YP_001525048.1 only a part of DnaA YP_001525062.1 protein prenyltransferase, subunit alpha YP_001525063.1 protein gp32 YP_001525067.1 DUF1320 YP_001525068.1 virion morphogenesis protein YP_001525083.1 GPD YP_001525084.1 GPD YP_001525092.1 Bordetella uptake (bug) protein YP_001525096.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol YP_001525097.1 LysR family YP_001525102.1 involved in chromosome partitioning YP_001525104.1 possibly involved in aromatic compounds catabolism YP_001525106.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001525107.1 forms a direct contact with the tRNA during translation YP_001525113.1 peptidase M20D YP_001525114.1 SirA_YedF_YeeD, SirA, YedF, and YeeD YP_001525115.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001525117.1 Represses a number of genes involved in the response to DNA damage YP_001525120.1 protein conserved in bacteria, COG4731 YP_001525121.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_001525122.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001525129.1 DUF140 YP_001525131.1 involved in resistance to organic solvents periplasmic component YP_001525132.1 COG3218 YP_001525136.1 glycosyltransferase YP_001525140.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001525143.1 DUF1476 YP_001525144.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001525146.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001525147.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001525149.1 PA-phosphatase YP_001525151.1 plasmid stabilization system YP_001525159.1 AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase YP_001525165.1 COG5491 YP_001525166.1 COG5490 YP_001525171.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_001525172.1 cobinamide phosphate guanyltransferase YP_001525173.1 BtuR/CobO/CobP YP_001525174.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_001525179.1 COG1238 YP_001525180.1 hydrolases of the beta-lactamase superfamily protein YP_001525185.1 reductase SDR YP_001525187.1 related enzymes of enolase superfamily YP_001525189.1 IclR family YP_001525195.1 AraC family YP_001525196.1 NtrB/NtrY YP_001525197.1 two component transcriptional regulator, LuxR family YP_001525201.1 DUF892 YP_001525203.1 Cro/CI family YP_001525209.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001525211.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001525212.1 ATP-dependent DNA ligase YP_001525214.1 SmpA / OmlA family YP_001525217.1 conserved in bacteria, COG2908 YP_001525218.1 2-oxohepta-3-ene-1,7-dioic acid hydratase YP_001525219.1 COG2170 YP_001525220.2 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001525222.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001525224.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001525226.1 Usg-like YP_001525228.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001525231.1 related glycosyltransferases of PMT family YP_001525237.1 DUF482 YP_001525238.1 COG3484 YP_001525241.1 cyclophilin type YP_001525242.1 cytidyltransferase-related YP_001525246.1 catalyzes the formation of O-acetyl -L-homoserine from L-homoserine and acetyl-CoA YP_001525248.1 class II YP_001525249.1 Bcr/CflA family YP_001525252.1 IclR family YP_001525256.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_001525257.1 dehydratase:short-chain dehydrogenase/reductase SDR YP_001525260.1 COG5649 YP_001525261.1 TetR family YP_001525262.1 epimerases/hydroxypyruvate isomerase YP_001525263.1 DUF993 YP_001525264.1 NAD-binding Rossmann fold YP_001525265.1 Mandelate racemase/muconate lactonizing enzyme YP_001525269.1 LysR family YP_001525270.1 oxoprolinase YP_001525271.1 hydantoinase/oxoprolinase YP_001525272.1 transphosphatidylase YP_001525273.1 protein conserved in bacteria, COG3184 YP_001525276.1 ErfK/YbiS/YcfS/YnhG YP_001525281.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001525282.1 C-terminal:DEAD/DEAH box helicase, N-terminal YP_001525289.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001525290.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001525292.1 biosynthetic type YP_001525297.1 DUF374 YP_001525299.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_001525301.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001525302.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001525309.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001525311.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001525312.1 Lys_tRNA synthetase (LysRS) class II core domain YP_001525313.1 COG2259 YP_001525314.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001525319.1 Involved in the biosynthetic pathways of fatty acids, phospholipids, lipopolysaccharides, and oligosaccharides YP_001525321.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001525322.1 FabF, beta-Ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP. YP_001525325.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001525326.1 fused to an ABC-type amino acid-binding protein YP_001525327.1 REC, signal receiver domain YP_001525328.1 GGDEF domain protein YP_001525331.1 HAMP region:bacterial chemotaxis sensory YP_001525335.1 DUF1217 YP_001525337.1 Enables the production of acetyl-CoA by phosphorylating acetate in the presence of ATP and a divalent cation YP_001525340.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_001525343.1 ECF-type sigma factor YP_001525348.1 COG3476 YP_001525349.1 COG4852 YP_001525350.1 DUF1295 YP_001525352.1 flavin-containing YP_001525353.1 DUF1365 YP_001525356.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_001525357.1 alpha/beta hydrolase fold YP_001525358.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_001525359.1 reductase SDR YP_001525360.1 GntR family YP_001525362.1 adducin, N-terminal, class II YP_001525367.1 Bleomycin resistance protein/dioxygenase superfamily YP_001525368.1 DGPFAETKE YP_001525369.1 ECF subfamily YP_001525370.1 GntR family YP_001525374.1 4-vinyl reductase YP_001525375.1 peptidase M19 YP_001525380.1 isochorismatase family YP_001525381.1 LysR family YP_001525389.1 MarR-family YP_001525395.1 IclR-family YP_001525399.1 GntR-family YP_001525405.1 flavin reductase like domain YP_001525407.1 Fis-type YP_001525408.1 periplasmic components YP_001525412.1 alpha/beta fold family YP_001525414.1 LysR family YP_001525417.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001525421.1 polysacc_deac_1 YP_001525422.1 Adh short YP_001525426.1 related permeases YP_001525428.1 yeaP YP_001525429.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001525431.1 C-terminal:DEAD/DEAH box helicase, N-terminal YP_001525432.1 GGDEF YP_001525433.1 GGDEF YP_001525434.1 N-terminal domain YP_001525435.1 similar ATP12 ATPase YP_001525436.1 subfamily IA, variant 1 YP_001525439.1 trapT family DctQ subunit YP_001525443.1 central region YP_001525445.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001525446.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the subunit alpha is the first step in the sequential assembly of subunits to form the holoenzyme YP_001525447.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001525449.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001525450.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001525451.1 late assembly protein YP_001525453.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001525454.1 binds 5S rRNA along with protein L5 and L25 YP_001525455.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001525456.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001525457.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001525458.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001525459.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001525461.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001525462.1 one of the stabilizing components for the large ribosomal subunit YP_001525463.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001525467.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001525468.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001525469.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001525470.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001525471.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001525472.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001525473.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001525474.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001525475.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001525476.1 DUF477 YP_001525477.1 DUF477 YP_001525479.1 GIY-YIG catalytic domain YP_001525481.1 protein conserved in bacteria, COG4318 YP_001525482.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001525484.1 protein related to arylsulfate sulfotransferase, COG4321 YP_001525487.1 protein conserved in bacteria, COG3521 YP_001525489.1 HAMP region:bacterial chemotaxis sensory YP_001525490.1 HAD-superfamily hydrolase, subfamily IB YP_001525491.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001525492.1 family (UPF0191) YP_001525493.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor YP_001525502.1 conserved in bacteria, COG3521 YP_001525503.1 with chaperone activity, ATP-binding subunit YP_001525504.1 DUF343 YP_001525505.1 DUF796 YP_001525507.1 DUF796 YP_001525508.1 DUF586 YP_001525511.1 DUF876 YP_001525514.1 ImpA-rel N YP_001525515.1 DUF770 YP_001525516.1 DUF877 YP_001525518.1 TPR, tetratricopeptide repeat domain YP_001525519.1 DUF1305 YP_001525522.1 involved in ubiquinone/menaquinone biosynthesis YP_001525524.1 Cupin, RmlC-type YP_001525527.1 LacI family YP_001525532.1 3-TM region, His/Glu/Gln/Arg/opine YP_001525533.1 3-TM region, His/Glu/Gln/Arg/opine YP_001525535.1 NAD binding domain YP_001525536.1 quinoprotein amine dehydrogenase, beta chain-like YP_001525538.1 GntR family YP_001525545.1 C-terminal YP_001525546.1 C-terminal YP_001525551.1 with a C-terminal OMP (outer membrane protein) domain YP_001525554.1 catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate YP_001525555.1 LysR family YP_001525559.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_001525563.1 GntR family YP_001525569.1 C-terminal YP_001525573.1 TetR family YP_001525578.1 C-terminal YP_001525583.1 HAE YP_001525586.1 LysR family YP_001525587.1 LysR family YP_001525588.1 DUF453 YP_001525590.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position YP_001525591.1 GntR-family YP_001525592.1 cold-shock DNA-binding domain YP_001525594.1 DUF6, transmembrane YP_001525596.1 3-TM region, His/Glu/Gln/Arg/opine YP_001525597.1 3-TM region, His/Glu/Gln/Arg/opine YP_001525598.1 family 3 precursor YP_001525599.1 BFD-like [2Fe-2S]-binding domain YP_001525602.1 Hop YP_001525604.1 Bleomycin resistance protein/dioxygenase superfamily protein YP_001525606.1 twin-arginine translocation pathway signal precursor YP_001525609.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_001525610.1 C-terminal YP_001525615.1 related hook-associated proteins YP_001525617.1 AraC family YP_001525619.1 PepSY-associated TM helix YP_001525620.1 the alpha/beta superfamily YP_001525621.1 HAD superfamily YP_001525625.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_001525628.1 HAMP region:bacterial chemotaxis sensory transducer YP_001525634.1 twin-arginine translocation pathway signal YP_001525643.1 DUF917 YP_001525645.1 ebsC YP_001525647.1 LysR-family YP_001525654.1 DeoR family YP_001525655.1 HAMP region:bacterial chemotaxis sensory YP_001525656.1 AraC family YP_001525658.1 protein related to deoxyribodipyrimidine photolyase, COG3046 YP_001525660.1 IrpA YP_001525664.1 DUF1513 YP_001525667.1 FAD/NAD(P)-binding oxidoreductase YP_001525669.1 GMP reductase:response regulator YP_001525670.1 ATP-binding region, ATPase-like:histidine kinase, HAMP region YP_001525676.1 PRC-barrel domain YP_001525681.1 with GGDEF motif YP_001525683.1 GntR family YP_001525684.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_001525685.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001525688.1 ligase YP_001525689.1 AsnC family YP_001525694.1 LacI family YP_001525696.1 aldo/keto reductase family YP_001525698.1 GATase1-like domain YP_001525699.1 LysR family YP_001525702.1 ferredoxin-NADPH reductases family YP_001525706.1 MarR family YP_001525711.1 DUF1185 YP_001525712.1 DUF1185 YP_001525713.1 DUF375 YP_001525715.1 carnitine dehydratase YP_001525721.1 proline-rich region YP_001525722.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001525724.1 YadR/YfhF family protein YP_001525727.1 MBOAT (membrane bound O-acyl transferase) family of membrane proteins with a variety of acyltransferase enzymes YP_001525730.1 TPR repeat, SEL1 subfamily YP_001525731.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001525732.1 conserved in bacteria YP_001525734.1 PCM-like YP_001525736.1 transmembrane region YP_001525737.1 peptidase aspartic, catalytic YP_001525743.1 HAMP region:bacterial chemotaxis sensory transducer YP_001525744.1 HAMP region:bacterial chemotaxis sensory transducer YP_001525745.1 UCP032025 YP_001525747.1 protein secE/sec61-gamma protein YP_001525750.1 containing a membrane domain, an EAL and a GGDEF domain YP_001525754.1 including N-acetylases of ribosomal proteins YP_001525759.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_001525760.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001525766.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_001525767.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001525770.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001525771.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001525772.1 LacI family YP_001525774.1 the major facilitator superfamily YP_001525775.1 AraC family YP_001525776.1 domain of unknown function (DUF323) YP_001525780.1 carnitine dehydratase YP_001525782.1 isomerase YP_001525790.1 ligase YP_001525797.1 DUF849 YP_001525798.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate YP_001525800.1 activator of 3-phenylpropionic acid catabolism YP_001525805.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_001525808.1 DUF598 YP_001525809.1 SecD/SecF/SecDF export membrane protein YP_001525810.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001525817.1 carbohydrate-binding family V/XII YP_001525818.1 LysR family YP_001525822.1 LysR family YP_001525827.1 amidase YP_001525828.1 MarR family YP_001525830.1 family M48 YP_001525832.1 group 1 family protein YP_001525833.1 group 1 family protein YP_001525834.1 oxoprolinase YP_001525840.1 with GAF sensor, Fis family YP_001525845.1 CoxI family protein YP_001525847.1 similar to bifunctional molybdopterin binding protein YP_001525850.1 protein containing von Willebrand factor type A (vWA) domain YP_001525851.1 central region:ATPase associated with various cellular activities YP_001525865.1 transmembrane region YP_001525866.1 family T4 YP_001525869.1 surfeit 1 YP_001525870.1 DUF983 YP_001525874.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001525877.1 Invasion associated locus B YP_001525882.1 LysR family YP_001525887.1 MerR family YP_001525892.1 TonB box, N-terminal YP_001525894.1 major facilitator superfamily MFS YP_001525897.1 HAMP region:bacterial chemotaxis sensory transducer YP_001525900.1 domain typically associated with flavoprotein oxygenases YP_001525902.1 twin-arginine translocation pathway signal YP_001525904.1 DUF214, permase YP_001525913.1 RpiR family YP_001525914.1 TetR family YP_001525923.1 with the helix-hairpin-helix motif YP_001525925.1 dehydratase family YP_001525926.1 LysR family YP_001525928.1 for C4-dicarboxylate transport YP_001525929.1 regulating C4-dicarboxylate transporter YP_001525931.1 DUF897 YP_001525933.1 DUF465 YP_001525934.1 LysR family YP_001525940.1 the beta-lactamase fold YP_001525941.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001525944.1 alpha/beta fold family YP_001525947.1 LysR family YP_001525954.1 IclR family YP_001525955.1 similar to AgaF of Agrobacterium tumefaciens YP_001525956.1 similar to AgaG of Agrobacterium tumefaciens YP_001525962.1 similar to ferredoxin YP_001525963.1 BFD-like [2Fe-2S]-binding domain YP_001525965.1 helix-turn-helix, AraC type YP_001525972.1 CorA-like Mg2+ transporter protein YP_001525974.1 response regulator receiver YP_001525975.1 DUF853, NPT hydrolase YP_001525977.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001525978.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis YP_001525980.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001525983.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001525985.1 pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; can cleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient YP_001525986.1 class I and II YP_001525987.1 peptidase M48, Ste24p YP_001525989.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001525991.1 biotin carboxylase YP_001525995.1 HSR1-related YP_001525996.1 Nif-regulating factor YP_001525998.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_001526002.1 Fis family YP_001526005.1 MECDP- synthase YP_001526006.1 C-terminal YP_001526007.1 metallo-dependent hydrolase, composite YP_001526008.1 surfeit locus 4-related YP_001526011.1 LuxR family YP_001526013.1 major facilitator superfamily YP_001526017.1 isochorismatase hydrolase YP_001526020.1 UPF0187 YP_001526021.1 DUF1194 YP_001526027.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001526033.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_001526034.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_001526036.1 neutral zinc metallopeptidases, zinc-binding site YP_001526039.1 ATP-independent RNA helicase YP_001526040.1 DUF930 YP_001526043.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001526044.1 Cupin, RmlC-type YP_001526045.1 DUF486 YP_001526047.1 like glutathione S-transferase YP_001526049.1 DUF992 YP_001526050.1 DUF992 YP_001526051.1 DUF992 YP_001526052.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_001526055.1 DUF519 YP_001526057.1 DUF1236 YP_001526058.1 class III YP_001526062.1 acyltransferases (alpha/beta hydrolase superfamily) YP_001526064.1 UCP032146 YP_001526065.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001526067.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001526069.1 sensory transducer with PAS domain YP_001526076.1 aliphatic sulphonates YP_001526079.1 aliphatic sulphonates precursor YP_001526088.1 DszA family YP_001526094.1 bacterial luciferase-like YP_001526095.1 transcriptional regulator, Rrf2 YP_001526097.1 3/MiaB/NifB YP_001526104.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001526105.1 reductase SDR precursor YP_001526106.1 catalyzes the conversion of salicylyl-CoA to gentisyl-CoA YP_001526113.1 bleomycin resistance protein/dioxygenase YP_001526114.1 IclR family YP_001526115.1 surface lipoprotein YP_001526122.1 transmembrane region:ABC transporter:peptidase C39, bacteriocin processing YP_001526123.1 contain an N-terminal double-glycine peptidase domain YP_001526129.1 interaction region YP_001526135.1 subunit WssH YP_001526139.1 AraC family YP_001526140.1 major facilitator family (MFS) YP_001526142.1 containing a membrane domain, an EAL and a GGDEF domain YP_001526147.1 TPR repeat YP_001526148.1 contains TPR repeats YP_001526153.1 Fe3+-siderophores transporters, ATPase components YP_001526154.1 ECF subfamily YP_001526163.1 Lysine N(6)-hydroxylase YP_001526165.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_001526174.1 N-4/N-6 YP_001526175.1 type III restriction enzyme, res subunit YP_001526178.1 catalytic region YP_001526180.1 FtsK/SpoIIIE and related protein YP_001526182.1 N-terminal YP_001526196.1 family 3 precursor YP_001526198.1 3-TM region, His/Glu/Gln/Arg/opine YP_001526199.1 3-TM region, His/Glu/Gln/Arg/opine YP_001526205.1 TetR family YP_001526206.1 peroxidase YP_001526207.1 DUF1486 YP_001526208.1 ATP-binding region YP_001526214.1 catalyzes the formation of malonyl-CoA from malonate and CoA YP_001526216.1 trapT family, dctQ subunit YP_001526217.1 trapT family, dctQ subunit YP_001526218.1 GMP reductase, transglutaminase-like YP_001526220.1 GMP reductase, transglutaminase-like YP_001526224.1 DUF262 YP_001526230.1 DUF949, bacterial YP_001526231.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001526233.1 YGGT YP_001526234.1 DUF167 YP_001526244.1 fused ATP-binding and membrane-spanning components YP_001526245.1 helix_turn_helix YP_001526249.1 contains double-stranded beta-helix domain YP_001526251.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_001526253.1 TRAP-type YP_001526264.1 reductase SDR YP_001526266.1 family UPF0065:Tat pathway signal precursor YP_001526268.1 LmbE homologs YP_001526273.1 LysR family YP_001526283.1 ligase YP_001526284.1 phosphopantetheine-binding YP_001526290.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_001526293.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_001526296.1 conserved in GGDEF domain protein YP_001526298.1 DUF58 YP_001526299.1 ABC transporter related YP_001526303.1 NUDIX hydrolase YP_001526306.1 FMN-binding split barrel YP_001526314.1 HisP-like nucleotide binding protein YP_001526321.1 amine oxidase family YP_001526322.1 ring-hydroxylating dioxygenases precursor YP_001526325.1 HesB/YadR/YfhF YP_001526329.1 glycoside hydrolase, family 6 YP_001526333.1 tetratricopeptide-like helical YP_001526334.1 with FeS4 cluster YP_001526339.1 DegT/DnrJ/EryC1/StrS family YP_001526341.1 FAD/NAD(P)-binding YP_001526343.1 Rieske [2Fe-2S] region YP_001526346.1 globin, bacterial type YP_001526352.1 tetratricopeptide-like helical YP_001526355.1 Ankyrin YP_001526359.1 nitrogenase iron protein; nitrogenase component 2; with component 1, an molybdenum-iron protein, catalyzes the fixation of nitrogen to ammonia; nitrogen reductase provides electrons to the nitrogenase complex; in R. etli there are three essentially identical copies of nifH which are actively expressed during symbiosis YP_001526361.1 FUR family YP_001526362.1 associates with NifD and may protect the nitrogenase Fe-Mo protein from oxidative damage YP_001526367.1 ORF1 YP_001526379.1 possibly involved in tellurium resistance YP_001526380.1 like to mitochondrial import inner membrane translocase, subunit Tim44 YP_001526382.1 TPR repeat YP_001526383.1 methyltransferase FkbM YP_001526388.1 GNAT family YP_001526391.1 methyltransferase YP_001526392.1 family 2 YP_001526397.1 GMP reductase, bacterial chemotaxis sensory transducer precursor YP_001526398.1 DUF1109 YP_001526399.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_001526401.1 DUF692 YP_001526404.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_001526408.1 adenylate cyclase YP_001526417.1 iron-sulfur subunit, twin-arginine translocation pathway signal YP_001526419.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001526424.1 DUF1285 YP_001526426.1 DUF58 YP_001526427.1 N-terminal YP_001526429.1 peptidase, cysteine peptidase active site YP_001526437.1 family 28 YP_001526438.1 drug resistance transporter EmrB/QacA subfamily YP_001526440.1 major facilitator superfamily YP_001526444.1 von Willebrand factor, type A YP_001526445.1 cyanovirin-N YP_001526446.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001526447.1 CsbD-like family YP_001526449.1 related acetyltransferases YP_001526452.1 Lysine exporter protein (LYSE/YGGA) YP_001526453.1 in CBS domain YP_001526454.1 catalyzes the formation of glutamate from glutamine YP_001526458.1 exonuclease, phosphatase YP_001526461.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_001526462.1 DUF6, transmembrane YP_001526463.1 quinonprotein alcohol dehydrogenase-like YP_001526464.1 Bordetella uptake gene YP_001526465.1 DUF1468 YP_001526466.1 DUF112, transmembrane YP_001526471.1 MarR family YP_001526482.1 with GGDEF domain YP_001526486.1 C-terminal catalytic domain YP_001526487.1 Prefoldin YP_001526507.1 Gp174 YP_001526514.1 helicase YP_001526523.1 bacteriophage and mitochondrial type YP_001526524.1 surfeit locus 4-related YP_001526525.1 HesB/YadR/YfhF YP_001526527.1 DUF59 YP_001526532.1 nifS-like protein YP_001526533.1 alpha/beta hydrolase fold-1 YP_001526534.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_001526535.1 class Ib YP_001526551.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA YP_001526552.1 CBS domain YP_001526554.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001526555.1 GatB/Yqey YP_001526557.1 DUF497 YP_001526558.1 synthesizes RNA primers at the replication forks YP_001526559.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_001526563.1 in Autotransporter beta-domain YP_001526565.1 ATP-binding region YP_001526567.1 ATP-binding region, ATPase-like YP_001526569.1 Rickettsia 17 kDa surface antigen YP_001526570.1 related GTPases of G3E family YP_001526571.1 conserved in cell wall hydrolase, SleB YP_001526572.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001526573.1 phosphopantetheine attachment site YP_001526575.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001526578.1 Rieske [2Fe-2S] region YP_001526582.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001526584.1 protein with 2 CBS domains YP_001526586.1 BTLCP YP_001526590.1 conserved in bacteria lipoprotein precursor YP_001526592.1 BolA-like protein YP_001526594.1 N-terminal YP_001526595.1 pCobS small subunit YP_001526596.1 CobT subunit YP_001526601.1 DUF540 YP_001526604.1 TetR/AcrR family YP_001526607.1 part of the metNIQ transporter for methionine YP_001526615.1 Cupin region YP_001526617.1 Enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_001526618.1 SUN-family protein YP_001526621.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001526627.1 effector binding precursor YP_001526630.1 HAMP region:bacterial chemotaxis sensory transducer precursor YP_001526632.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001526634.1 sensory transducer precursor YP_001526635.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001526636.1 Ste24p YP_001526637.1 MiaB/NifB YP_001526639.1 quinoprotein amine dehydrogenase, beta chain-like YP_001526645.1 twin-arginine translocation pathway signal YP_001526647.1 USG-1 related YP_001526648.1 virulence factor, pectin lyase fold YP_001526656.1 formate antiporter YP_001526661.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001526668.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_001526678.1 lipase-like YP_001526681.1 related esterases precursor YP_001526682.1 response regulator hybrid protein YP_001526685.1 carboxymuconolactone decarboxylase YP_001526687.1 LysR family YP_001526695.1 family 5 precursor YP_001526696.1 molybdopterin-binding YP_001526706.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001526707.1 Cupin region YP_001526709.1 catalytic region YP_001526710.1 helix-turn-helix, AraC type:ThiJ/PfpI; transcriptional regulator YP_001526716.1 P47K YP_001526719.1 LysR family YP_001526724.1 reductase SDR YP_001526727.1 nodulation fucosyltransferase YP_001526728.1 the two-components ABC-transporter protein YP_001526729.1 nodulation ATP-binding protein I YP_001526730.1 6-O-carbamoyl transferase YP_001526731.1 methyltransferase YP_001526734.1 catalyzes the transfer of a fatty acyl group onto Nod factor, beta-(1,4)-N-acetylglucosamine oligosaccharide YP_001526742.1 helix-turn-helix, Fis-type YP_001526743.1 type IV secretion VirD4 coupling protein family YP_001526748.1 Ribbon-helix-helix YP_001526751.1 DNA binding YP_001526758.1 DUF736 YP_001526763.1 HAMP region, bacterial chemotaxis sensory transducer precursor YP_001526765.1 catalytic region YP_001526766.1 nolK YP_001526770.1 LysR family YP_001526772.1 filamentation induced by cAMP protein Fic YP_001526777.1 type IV secretion system VirB4 family YP_001526780.1 type IV secretion VirB6 family YP_001526782.1 VirB9/CagX precursor YP_001526783.1 bacterial conjugation TrbI-like protein YP_001526800.1 formamidase YP_001526809.1 related metal-dependent hydrolases YP_001526814.1 reductase YP_001526818.1 EAL precursor YP_001526823.1 SNase-like precursor YP_001526826.1 HAE1 YP_001526830.1 GGDEF with PAS/PAC domain YP_001526836.1 abortive infection protein YP_001526837.1 abortive infection protein YP_001526839.1 ATP-binding region, histidine kinase A, N-terminal precursor YP_001526840.1 ORF3 YP_001526843.1 OstA-like protein YP_001526844.1 conserved in bacteria precursor YP_001526846.1 FYDLN acid YP_001526848.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001526853.1 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate YP_001526854.1 catalyzes the formation of precorrin-3 from precorrin-2 YP_001526855.1 catalyzes the formation of precorrin-4 from precorrin-3B and S-adenosyl-L-methionine YP_001526856.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential YP_001526857.1 CbiJ/CobK YP_001526858.1 decarboxylating protein YP_001526861.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A YP_001526862.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_001526866.1 including glyoxylases YP_001526868.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001526869.1 Essential for efficient processing of 16S rRNA YP_001526875.1 DegT/DnrJ/EryC1/StrS YP_001526876.1 IMP dehydrogenase/GMP reductase YP_001526881.1 family 3 YP_001526887.1 conserved in GGDEF domain YP_001526888.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001526894.1 bacterial regulatory protein, TetR YP_001526897.1 DUF526 YP_001526899.1 DUF185 YP_001526900.1 DUF152 YP_001526904.1 fused ATPase and permease components YP_001526906.1 class III YP_001526910.1 DUF214, permase YP_001526915.1 PA-phosphatase related YP_001526916.1 DUF188 YP_001526918.1 PadR family YP_001526919.1 integrase/recombinase RipX YP_001526925.1 Catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001526926.1 LysE family YP_001526928.1 YCII-related YP_001526929.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001526932.1 Catalyzes the reversible oxidation of malate to oxaloacetate YP_001526936.1 Catalyzes the deamination of dCTP to form dUTP YP_001526939.1 large permease component YP_001526940.1 protein associated with Co2+ and Mg2+ efflux YP_001526942.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001526943.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_001526958.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_001526962.1 nitroreductase YP_001526966.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001526969.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001526973.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001526975.1 DUF1025 YP_001526977.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001526979.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001526980.1 FMN-binding split barrel YP_001526982.1 ATP-binding region, HAMP region YP_001526985.1 HPr-related protein YP_001526996.1 DUF1445 YP_001526997.1 LysR family YP_001526998.1 alpha/beta hydrolase fold YP_001527001.1 rubrerythrin YP_001527004.1 polyphosphate kinase 2 YP_001527005.1 stationary phase that binds TrpR repressor YP_001527006.1 hydrolyzes diadenosine polyphosphate YP_001527009.1 involved in the peptidyltransferase reaction during translation YP_001527012.1 with GGDEF motif, DUF1 YP_001527014.1 methyltransferase type 11 YP_001527024.1 LuxR family YP_001527028.1 duplicated ATPase domains YP_001527031.1 catalytic subdomain YP_001527032.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001527038.1 DUF6, transmembrane YP_001527039.1 LysR family YP_001527040.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001527041.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001527042.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001527043.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001527046.1 3-TM region, His/Glu/Gln/Arg/opine YP_001527047.1 4-TM region, His/Glu/Gln/Arg/opine YP_001527049.1 C-terminal protease precursor YP_001527051.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001527054.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001527055.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001527056.1 homeodomain-like YP_001527060.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001527062.1 cytochrome c YP_001527063.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001527064.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001527066.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001527071.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001527072.1 possibly involved in tellurium resistance YP_001527073.1 TerC family YP_001527075.1 DUF1275 YP_001527080.1 carbohydrate-binding family V/XII YP_001527081.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_001527083.1 6-pyruvoyl tetrahydropterin synthase and hypothetical protein YP_001527087.1 riboflavin biosynthesis YP_001527088.1 catalyzes the formation of formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine from GTP YP_001527089.1 reductase SDR YP_001527090.1 group 1 YP_001527092.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; also known as acetolactate synthase large subunit YP_001527094.1 LysR family YP_001527100.1 subunit I transmembrane YP_001527102.1 catalyzes the oxidation of malate to oxaloacetate YP_001527103.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_001527108.1 group 1 family protein YP_001527110.1 with different specificities (related to short-chain alcohol dehydrogenases) YP_001527112.1 peptidoglycan-binding LysM YP_001527116.1 central region, Clp, N terminal YP_001527117.1 DUF1348 YP_001527118.1 TetR family YP_001527119.1 peptidase M24A, subfamily 1 YP_001527120.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001527122.1 protease inhibitor, beta barrel YP_001527128.1 UPF0114 YP_001527139.1 HAMP region precursor, protein phosphatase 2C-like YP_001527140.1 major facilitator superfamily YP_001527145.1 UbiH/UbiF/VisC/COQ6 YP_001527147.1 HicB YP_001527150.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001527151.1 MOSC domain YP_001527154.1 Regulatory factor involved in maltose metabolism YP_001527155.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family; some organisms carry two different copies of this enzyme YP_001527156.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001527162.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001527163.1 OsmC-like protein YP_001527164.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein YP_001527165.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein YP_001527166.1 the drug/metabolite transporter (DMT) superfamily YP_001527168.1 conserved in bacteria precursor YP_001527169.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001527172.1 lon N-terminal YP_001527176.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001527180.1 conserved in bacteria YP_001527184.1 inositol monophosphatase YP_001527190.1 nodulation efficiency, NfeD YP_001527191.1 LytR/AlgR family YP_001527192.1 aldehyde dehydrogenase YP_001527198.1 nicotinamidase YP_001527199.1 DUF1236 YP_001527203.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_001527205.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001527206.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001527209.1 DUF156 YP_001527214.1 DUF1178 YP_001527217.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001527218.1 acyltransferases, alpha/beta hydrolase superfamily YP_001527219.1 virulence factor MVIN-like YP_001527220.1 C-terminal domain YP_001527221.1 N-terminal domain YP_001527223.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001527224.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001527230.1 carries the fatty acid chain in fatty acid biosynthesis YP_001527234.1 Essential for recycling GMP and indirectly, cGMP YP_001527235.1 histidine acid phosphatase YP_001527236.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001527242.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_001527243.1 conserved in bacteria, ErfK_YbiS_YhnG, ErfK/YbiS/YcfS/YnhG YP_001527244.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001527248.1 NnrU YP_001527254.1 conserved in bacteria, ErfK YP_001527257.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_001527262.1 UbiE/COQ5 family YP_001527264.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_001527266.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001527268.1 molecular chaperone YP_001527271.1 20 kDa subunit YP_001527272.1 chain 49kDa YP_001527277.1 helix-turn-helix motif YP_001527295.1 reductase SDR YP_001527298.1 bacterial cytochrome c, class IC YP_001527299.1 antibiotic biosynthesis monooxygenase YP_001527300.1 TonB-dependent haem/haemoglobin receptor precursor YP_001527305.1 TetR-family YP_001527306.1 HlyD family YP_001527309.1 Hsp70 class YP_001527320.1 LacI family YP_001527321.1 3-TM region, His/Glu/Gln/Arg/opine YP_001527322.1 3-TM region, His/Glu/Gln/Arg/opine YP_001527329.1 regulatory protein, FmdB YP_001527331.1 UPF0118 YP_001527332.1 involved in lipopolysaccharide synthesis precursor YP_001527337.1 WecB/TagA/CpsF YP_001527338.1 involved in polysaccharide export YP_001527339.1 involved in exopolysaccharide biosynthesis YP_001527340.1 involved in the export of O-antigen and teichoic acid YP_001527344.1 the alpha/beta superfamily YP_001527350.1 peptidase M29 YP_001527354.1 containing a membrane domain, an EAL and a GGDEF domain YP_001527357.1 FAD dependent oxidoreductase YP_001527360.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001527364.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001527367.1 amine oxidase YP_001527378.1 DUF1223 YP_001527384.1 LacI family YP_001527387.1 UPF0102 YP_001527388.1 uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001527389.1 GMP reductase, extracellular ligand-binding receptor YP_001527397.1 oxidoreductase YP_001527398.1 involved in outer membrane biogenesis precursor YP_001527401.1 DUF1321 YP_001527406.1 monofunctional class YP_001527408.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001527412.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001527413.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_001527414.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001527415.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001527416.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001527418.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_001527424.1 Glu/Leu/Phe/Val dehydrogenase YP_001527425.1 AhpD YP_001527439.1 CcoN; FixN YP_001527440.1 CcoO; FixO YP_001527445.1 Copper-translocating P-type ATPase, heavy metal translocating P-type ATPase YP_001527446.1 possibly involved in nitrogen fixation YP_001527449.1 twin-arginine translocation pathway signal precursor YP_001527450.1 IclR family YP_001527451.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001527452.1 activates fatty acids by binding to coenzyme A YP_001527457.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001527465.1 family 2 YP_001527471.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001527472.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001527476.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001527477.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001527480.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001527481.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001527482.1 including glyoxylases YP_001527485.1 TetR family YP_001527491.1 class I peptide chain release factor domain YP_001527496.1 methyltransferase YP_001527497.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001527506.1 TetR family YP_001527508.1 isomerase YP_001527511.1 DUF6, transmembrane YP_001527516.1 subunit Tim44 YP_001527517.1 outer membrane lipoprotein GNA33 YP_001527518.1 MutS2 C-terminal YP_001527519.1 helix-turn-helix motif YP_001527522.1 transmembrane YP_001527534.1 prephenate dehydrogenase precursor YP_001527535.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001527538.1 FAD-binding YP_001527545.1 involved in polysaccharide export YP_001527546.1 involved in chromosome partitioning YP_001527553.1 ExoQ family, involved in exopolysaccharide production YP_001527555.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001527556.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001527558.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_001527560.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001527561.1 activates RNA polymerase to cleave back-tracked RNA during elongational pausing YP_001527563.1 helix-turn-helix motif YP_001527567.1 DUF1052 YP_001527573.1 CoA binding domain YP_001527579.1 thioredoxins YP_001527585.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_001527586.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001527588.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001527589.1 DUF1674 YP_001527591.1 C-terminal YP_001527593.1 dehydratase YP_001527599.1 possibly involved in utilization of glycolate and propanediol YP_001527601.1 LysR family YP_001527602.1 NAD(P)H nitroreductase YP_001527603.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_001527606.1 DUF45 YP_001527608.1 ATPase-like ATP-binding region YP_001527609.1 helix-turn-helix, Fis-type YP_001527612.1 involved in de novo purine biosynthesis YP_001527615.1 TetR family YP_001527617.1 metalloprotease YP_001527618.1 antibiotic restance protein YP_001527619.1 C-terminal YP_001527620.1 M22 metalloprotease YP_001527623.1 containing a thioredoxin domain YP_001527624.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001527625.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001527626.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001527630.1 This protein performs the mismatch recognition step during the DNA repair process YP_001527631.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes