-- dump date 20140618_210309 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1064539000001 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1064539000002 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1064539000003 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1064539000004 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539000005 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1064539000006 lipoyl synthase; Provisional; Region: PRK05481 1064539000007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539000008 FeS/SAM binding site; other site 1064539000009 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1064539000010 putative coenzyme Q binding site [chemical binding]; other site 1064539000011 Competence-damaged protein; Region: CinA; pfam02464 1064539000012 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1064539000013 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1064539000014 substrate binding site; other site 1064539000015 dimer interface; other site 1064539000016 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1064539000017 homotrimer interaction site [polypeptide binding]; other site 1064539000018 zinc binding site [ion binding]; other site 1064539000019 CDP-binding sites; other site 1064539000020 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1064539000021 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1064539000022 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 1064539000023 FMN binding site [chemical binding]; other site 1064539000024 active site 1064539000025 catalytic residues [active] 1064539000026 substrate binding site [chemical binding]; other site 1064539000027 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1064539000028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539000029 putative active site [active] 1064539000030 heme pocket [chemical binding]; other site 1064539000031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539000032 dimer interface [polypeptide binding]; other site 1064539000033 phosphorylation site [posttranslational modification] 1064539000034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539000035 ATP binding site [chemical binding]; other site 1064539000036 Mg2+ binding site [ion binding]; other site 1064539000037 G-X-G motif; other site 1064539000038 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1064539000039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539000040 active site 1064539000041 phosphorylation site [posttranslational modification] 1064539000042 intermolecular recognition site; other site 1064539000043 dimerization interface [polypeptide binding]; other site 1064539000044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539000045 Walker A motif; other site 1064539000046 ATP binding site [chemical binding]; other site 1064539000047 Walker B motif; other site 1064539000048 arginine finger; other site 1064539000049 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1064539000050 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539000051 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539000052 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1064539000053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539000054 active site 1064539000055 phosphorylation site [posttranslational modification] 1064539000056 intermolecular recognition site; other site 1064539000057 dimerization interface [polypeptide binding]; other site 1064539000058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539000059 Walker A motif; other site 1064539000060 ATP binding site [chemical binding]; other site 1064539000061 Walker B motif; other site 1064539000062 arginine finger; other site 1064539000063 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539000064 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1064539000065 TrkA-N domain; Region: TrkA_N; pfam02254 1064539000066 TrkA-C domain; Region: TrkA_C; pfam02080 1064539000067 TrkA-N domain; Region: TrkA_N; pfam02254 1064539000068 TrkA-C domain; Region: TrkA_C; pfam02080 1064539000069 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1064539000070 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1064539000071 homodimer interface [polypeptide binding]; other site 1064539000072 substrate-cofactor binding pocket; other site 1064539000073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539000074 catalytic residue [active] 1064539000075 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 1064539000076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539000077 motif II; other site 1064539000078 bacterial Hfq-like; Region: Hfq; cd01716 1064539000079 hexamer interface [polypeptide binding]; other site 1064539000080 Sm1 motif; other site 1064539000081 RNA binding site [nucleotide binding]; other site 1064539000082 Sm2 motif; other site 1064539000083 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1064539000084 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1064539000085 HflX GTPase family; Region: HflX; cd01878 1064539000086 G1 box; other site 1064539000087 GTP/Mg2+ binding site [chemical binding]; other site 1064539000088 Switch I region; other site 1064539000089 G2 box; other site 1064539000090 G3 box; other site 1064539000091 Switch II region; other site 1064539000092 G4 box; other site 1064539000093 G5 box; other site 1064539000094 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 1064539000095 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1064539000096 active site 1064539000097 putative lithium-binding site [ion binding]; other site 1064539000098 substrate binding site [chemical binding]; other site 1064539000099 Geminivirus putative movement protein; Region: Gemini_mov; pfam01708 1064539000100 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1064539000101 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1064539000102 homodimer interface [polypeptide binding]; other site 1064539000103 metal binding site [ion binding]; metal-binding site 1064539000104 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1064539000105 homodimer interface [polypeptide binding]; other site 1064539000106 active site 1064539000107 putative chemical substrate binding site [chemical binding]; other site 1064539000108 metal binding site [ion binding]; metal-binding site 1064539000109 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1064539000110 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1064539000111 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1064539000112 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1064539000113 hydrogenase 4 subunit F; Validated; Region: PRK06458 1064539000114 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1064539000115 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 1064539000116 NADH dehydrogenase; Region: NADHdh; cl00469 1064539000117 potential frameshift: common BLAST hit: gi|27381450|ref|NP_772979.1| hydrogenase 4 subunit B 1064539000118 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1064539000119 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1064539000120 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1064539000121 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1064539000122 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1064539000123 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1064539000124 RNA binding site [nucleotide binding]; other site 1064539000125 PAS domain S-box; Region: sensory_box; TIGR00229 1064539000126 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539000127 putative active site [active] 1064539000128 heme pocket [chemical binding]; other site 1064539000129 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539000130 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539000131 metal binding site [ion binding]; metal-binding site 1064539000132 active site 1064539000133 I-site; other site 1064539000134 LysE type translocator; Region: LysE; cl00565 1064539000135 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1064539000136 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1064539000137 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1064539000138 homoserine O-acetyltransferase; Provisional; Region: PRK06765 1064539000139 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1064539000140 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539000141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539000142 active site 1064539000143 phosphorylation site [posttranslational modification] 1064539000144 intermolecular recognition site; other site 1064539000145 dimerization interface [polypeptide binding]; other site 1064539000146 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1064539000147 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1064539000148 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1064539000149 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1064539000150 putative C-terminal domain interface [polypeptide binding]; other site 1064539000151 putative GSH binding site (G-site) [chemical binding]; other site 1064539000152 putative dimer interface [polypeptide binding]; other site 1064539000153 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1064539000154 N-terminal domain interface [polypeptide binding]; other site 1064539000155 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1064539000156 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1064539000157 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10400573; Product type e : enzyme 1064539000158 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10400573; Product type e : enzyme 1064539000159 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1064539000160 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1064539000161 active site 1064539000162 DNA binding site [nucleotide binding] 1064539000163 Int/Topo IB signature motif; other site 1064539000164 catalytic residues [active] 1064539000165 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 1064539000166 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539000167 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539000168 dimer interface [polypeptide binding]; other site 1064539000169 putative CheW interface [polypeptide binding]; other site 1064539000170 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1064539000171 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539000172 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539000173 catalytic residue [active] 1064539000174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539000175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539000176 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539000177 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539000178 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539000179 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1064539000180 Protein export membrane protein; Region: SecD_SecF; cl14618 1064539000181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539000182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539000183 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1064539000184 putative dimerization interface [polypeptide binding]; other site 1064539000185 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1064539000186 Protein export membrane protein; Region: SecD_SecF; cl14618 1064539000187 potential frameshift: common BLAST hit: gi|374291568|ref|YP_005038603.1| multidrug efflux system, subunit A (AcrB family) 1064539000188 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539000189 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539000190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539000191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539000192 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064539000193 dimerization interface [polypeptide binding]; other site 1064539000194 hypothetical protein; Provisional; Region: PRK05463 1064539000195 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539000196 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1064539000197 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1064539000198 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1064539000199 DctM-like transporters; Region: DctM; pfam06808 1064539000200 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1064539000201 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1064539000202 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1064539000203 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1064539000204 putative active site [active] 1064539000205 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539000206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539000207 active site 1064539000208 phosphorylation site [posttranslational modification] 1064539000209 intermolecular recognition site; other site 1064539000210 dimerization interface [polypeptide binding]; other site 1064539000211 PAS fold; Region: PAS_4; pfam08448 1064539000212 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1064539000213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539000214 dimer interface [polypeptide binding]; other site 1064539000215 phosphorylation site [posttranslational modification] 1064539000216 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1064539000217 ATP binding site [chemical binding]; other site 1064539000218 Mg2+ binding site [ion binding]; other site 1064539000219 G-X-G motif; other site 1064539000220 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1064539000221 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1064539000222 G1 box; other site 1064539000223 putative GEF interaction site [polypeptide binding]; other site 1064539000224 GTP/Mg2+ binding site [chemical binding]; other site 1064539000225 Switch I region; other site 1064539000226 G2 box; other site 1064539000227 G3 box; other site 1064539000228 Switch II region; other site 1064539000229 G4 box; other site 1064539000230 G5 box; other site 1064539000231 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1064539000232 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1064539000233 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1064539000234 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1064539000235 homodimer interface [polypeptide binding]; other site 1064539000236 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1064539000237 active site pocket [active] 1064539000238 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1064539000239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539000240 Coenzyme A binding pocket [chemical binding]; other site 1064539000241 Peptidase_C39 like family; Region: DUF3335; pfam11814 1064539000242 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1064539000243 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1064539000244 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1064539000245 RNA polymerase sigma factor; Provisional; Region: PRK12547 1064539000246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539000247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539000248 DNA binding residues [nucleotide binding] 1064539000249 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1064539000250 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1064539000251 putative active site [active] 1064539000252 putative metal binding site [ion binding]; other site 1064539000253 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539000254 EamA-like transporter family; Region: EamA; pfam00892 1064539000255 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1064539000256 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1064539000257 potential frameshift: common BLAST hit: gi|374293940|ref|YP_005040963.1| putative cation/proton antiporter, Na+/H+ exchanger family 1064539000258 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539000259 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539000260 ligand binding site [chemical binding]; other site 1064539000261 flexible hinge region; other site 1064539000262 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1064539000263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539000264 ATP binding site [chemical binding]; other site 1064539000265 Mg2+ binding site [ion binding]; other site 1064539000266 G-X-G motif; other site 1064539000267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539000268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539000269 active site 1064539000270 phosphorylation site [posttranslational modification] 1064539000271 intermolecular recognition site; other site 1064539000272 dimerization interface [polypeptide binding]; other site 1064539000273 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1064539000274 DNA binding site [nucleotide binding] 1064539000275 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1064539000276 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1064539000277 Transcriptional regulator; Region: Rrf2; pfam02082 1064539000278 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1064539000279 putative ABC transporter; Region: ycf24; CHL00085 1064539000280 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1064539000281 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1064539000282 Walker A/P-loop; other site 1064539000283 ATP binding site [chemical binding]; other site 1064539000284 Q-loop/lid; other site 1064539000285 ABC transporter signature motif; other site 1064539000286 Walker B; other site 1064539000287 D-loop; other site 1064539000288 H-loop/switch region; other site 1064539000289 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1064539000290 FeS assembly protein SufD; Region: sufD; TIGR01981 1064539000291 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1064539000292 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1064539000293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539000294 catalytic residue [active] 1064539000295 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1064539000296 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1064539000297 trimerization site [polypeptide binding]; other site 1064539000298 active site 1064539000299 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 1064539000300 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1064539000301 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1064539000302 aminopeptidase N; Provisional; Region: pepN; PRK14015 1064539000303 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1064539000304 active site 1064539000305 Zn binding site [ion binding]; other site 1064539000306 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1064539000307 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1064539000308 putative hydrophobic ligand binding site [chemical binding]; other site 1064539000309 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1064539000310 catalytic center binding site [active] 1064539000311 ATP binding site [chemical binding]; other site 1064539000312 Dihydroneopterin aldolase; Region: FolB; smart00905 1064539000313 active site 1064539000314 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1064539000315 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064539000316 Ligand Binding Site [chemical binding]; other site 1064539000317 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1064539000318 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1064539000319 Flagellar protein FlaF; Region: FlaF; cl11454 1064539000320 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1064539000321 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539000322 EamA-like transporter family; Region: EamA; pfam00892 1064539000323 EamA-like transporter family; Region: EamA; pfam00892 1064539000324 PAS domain; Region: PAS; smart00091 1064539000325 PAS domain; Region: PAS_9; pfam13426 1064539000326 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539000327 PAS domain; Region: PAS_9; pfam13426 1064539000328 putative active site [active] 1064539000329 heme pocket [chemical binding]; other site 1064539000330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539000331 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539000332 putative active site [active] 1064539000333 heme pocket [chemical binding]; other site 1064539000334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539000335 putative active site [active] 1064539000336 heme pocket [chemical binding]; other site 1064539000337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539000338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539000339 ATP binding site [chemical binding]; other site 1064539000340 Mg2+ binding site [ion binding]; other site 1064539000341 G-X-G motif; other site 1064539000342 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539000343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539000344 active site 1064539000345 phosphorylation site [posttranslational modification] 1064539000346 intermolecular recognition site; other site 1064539000347 dimerization interface [polypeptide binding]; other site 1064539000348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539000349 putative substrate translocation pore; other site 1064539000350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539000351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539000352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064539000353 dimerization interface [polypeptide binding]; other site 1064539000354 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 1064539000355 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 1064539000356 putative dimer interface [polypeptide binding]; other site 1064539000357 [2Fe-2S] cluster binding site [ion binding]; other site 1064539000358 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 1064539000359 putative dimer interface [polypeptide binding]; other site 1064539000360 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1064539000361 SLBB domain; Region: SLBB; pfam10531 1064539000362 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1064539000363 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1064539000364 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064539000365 catalytic loop [active] 1064539000366 iron binding site [ion binding]; other site 1064539000367 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1064539000368 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1064539000369 [4Fe-4S] binding site [ion binding]; other site 1064539000370 molybdopterin cofactor binding site; other site 1064539000371 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1064539000372 molybdopterin cofactor binding site; other site 1064539000373 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1064539000374 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1064539000375 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1064539000376 MarR family; Region: MarR_2; pfam12802 1064539000377 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1064539000378 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1064539000379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539000380 FeS/SAM binding site; other site 1064539000381 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1064539000382 dimer interface [polypeptide binding]; other site 1064539000383 putative tRNA-binding site [nucleotide binding]; other site 1064539000384 Phasin protein; Region: Phasin_2; pfam09361 1064539000385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539000386 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1064539000387 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1064539000388 HflX GTPase family; Region: HflX; cd01878 1064539000389 G1 box; other site 1064539000390 GTP/Mg2+ binding site [chemical binding]; other site 1064539000391 Switch I region; other site 1064539000392 G2 box; other site 1064539000393 G3 box; other site 1064539000394 Switch II region; other site 1064539000395 G4 box; other site 1064539000396 G5 box; other site 1064539000397 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1064539000398 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1064539000399 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1064539000400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1064539000401 Histidine kinase; Region: HisKA_2; pfam07568 1064539000402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539000403 ATP binding site [chemical binding]; other site 1064539000404 Mg2+ binding site [ion binding]; other site 1064539000405 G-X-G motif; other site 1064539000406 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 1064539000407 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1064539000408 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1064539000409 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1064539000410 catalytic residues [active] 1064539000411 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1064539000412 DNA binding site [nucleotide binding] 1064539000413 Int/Topo IB signature motif; other site 1064539000414 active site 1064539000415 catalytic residues [active] 1064539000416 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1064539000417 catalytic residues [active] 1064539000418 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1064539000419 structural protein; Region: PHA01972 1064539000420 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1064539000421 hypothetical protein; Region: PHA00661 1064539000422 hypothetical protein; Region: PHA00662 1064539000423 major capsid protein; Region: PHA00665 1064539000424 hypothetical protein; Region: PHA00670 1064539000425 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 1064539000426 Terminase-like family; Region: Terminase_6; pfam03237 1064539000427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539000428 non-specific DNA binding site [nucleotide binding]; other site 1064539000429 salt bridge; other site 1064539000430 sequence-specific DNA binding site [nucleotide binding]; other site 1064539000431 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1064539000432 active site 1064539000433 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1064539000434 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1064539000435 Walker A motif; other site 1064539000436 ATP binding site [chemical binding]; other site 1064539000437 Walker B motif; other site 1064539000438 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1064539000439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539000440 sequence-specific DNA binding site [nucleotide binding]; other site 1064539000441 salt bridge; other site 1064539000442 Predicted transcriptional regulator [Transcription]; Region: COG2932 1064539000443 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1064539000444 Catalytic site [active] 1064539000445 Ribbon-helix-helix domain; Region: RHH_4; cl01775 1064539000446 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1064539000447 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1064539000448 Catalytic site; other site 1064539000449 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 1064539000450 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1064539000451 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1064539000452 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1064539000453 active site 1064539000454 catalytic residues [active] 1064539000455 DNA binding site [nucleotide binding] 1064539000456 Int/Topo IB signature motif; other site 1064539000457 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1064539000458 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1064539000459 active site 1064539000460 (T/H)XGH motif; other site 1064539000461 DNA gyrase subunit A; Validated; Region: PRK05560 1064539000462 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1064539000463 CAP-like domain; other site 1064539000464 active site 1064539000465 primary dimer interface [polypeptide binding]; other site 1064539000466 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064539000467 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064539000468 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064539000469 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064539000470 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064539000471 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064539000472 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1064539000473 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1064539000474 cation binding site [ion binding]; other site 1064539000475 Predicted small secreted protein [Function unknown]; Region: COG5510 1064539000476 ribulokinase; Provisional; Region: PRK04123 1064539000477 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1064539000478 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1064539000479 dimer interface [polypeptide binding]; other site 1064539000480 ssDNA binding site [nucleotide binding]; other site 1064539000481 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1064539000482 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1064539000483 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1064539000484 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1064539000485 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1064539000486 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1064539000487 putative hydrophobic ligand binding site [chemical binding]; other site 1064539000488 protein interface [polypeptide binding]; other site 1064539000489 gate; other site 1064539000490 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1064539000491 Glucose inhibited division protein A; Region: GIDA; pfam01134 1064539000492 Cache domain; Region: Cache_1; pfam02743 1064539000493 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539000494 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539000495 dimer interface [polypeptide binding]; other site 1064539000496 putative CheW interface [polypeptide binding]; other site 1064539000497 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 1064539000498 substrate binding pocket [chemical binding]; other site 1064539000499 substrate-Mg2+ binding site; other site 1064539000500 aspartate-rich region 1; other site 1064539000501 aspartate-rich region 2; other site 1064539000502 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1064539000503 active site lid residues [active] 1064539000504 substrate binding pocket [chemical binding]; other site 1064539000505 catalytic residues [active] 1064539000506 substrate-Mg2+ binding site; other site 1064539000507 aspartate-rich region 1; other site 1064539000508 aspartate-rich region 2; other site 1064539000509 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1064539000510 active site lid residues [active] 1064539000511 catalytic residues [active] 1064539000512 substrate binding pocket [chemical binding]; other site 1064539000513 substrate-Mg2+ binding site; other site 1064539000514 aspartate-rich region 1; other site 1064539000515 aspartate-rich region 2; other site 1064539000516 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1064539000517 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1064539000518 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1064539000519 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1064539000520 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 1064539000521 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1064539000522 Protein export membrane protein; Region: SecD_SecF; pfam02355 1064539000523 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1064539000524 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1064539000525 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1064539000526 Preprotein translocase subunit; Region: YajC; pfam02699 1064539000527 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1064539000528 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1064539000529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539000530 Walker A motif; other site 1064539000531 ATP binding site [chemical binding]; other site 1064539000532 Walker B motif; other site 1064539000533 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064539000534 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064539000535 potential frameshift: common BLAST hit: gi|374291905|ref|YP_005038940.1| putative gamma-D-glutamyl-meso-diaminopimelate peptidase 1064539000536 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1064539000537 Peptidase family M23; Region: Peptidase_M23; pfam01551 1064539000538 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1064539000539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539000540 S-adenosylmethionine binding site [chemical binding]; other site 1064539000541 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1064539000542 seryl-tRNA synthetase; Provisional; Region: PRK05431 1064539000543 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1064539000544 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1064539000545 dimer interface [polypeptide binding]; other site 1064539000546 active site 1064539000547 motif 1; other site 1064539000548 motif 2; other site 1064539000549 motif 3; other site 1064539000550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539000551 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1064539000552 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1064539000553 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 1064539000554 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1064539000555 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1064539000556 Walker A/P-loop; other site 1064539000557 ATP binding site [chemical binding]; other site 1064539000558 Q-loop/lid; other site 1064539000559 ABC transporter signature motif; other site 1064539000560 Walker B; other site 1064539000561 D-loop; other site 1064539000562 H-loop/switch region; other site 1064539000563 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1064539000564 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1064539000565 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1064539000566 Peptidase family M50; Region: Peptidase_M50; pfam02163 1064539000567 active site 1064539000568 putative substrate binding region [chemical binding]; other site 1064539000569 potential frameshift: common BLAST hit: gi|288960184|ref|YP_003450524.1| beta-N-acetylhexosaminidase 1064539000570 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1064539000571 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1064539000572 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1064539000573 Sporulation related domain; Region: SPOR; pfam05036 1064539000574 potential frameshift: common BLAST hit: gi|374998658|ref|YP_004974157.1| arginyl-tRNA synthetase 1064539000575 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 1064539000576 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1064539000577 active site 1064539000578 HIGH motif; other site 1064539000579 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1064539000580 KMSK motif region; other site 1064539000581 tRNA binding surface [nucleotide binding]; other site 1064539000582 DALR anticodon binding domain; Region: DALR_1; smart00836 1064539000583 anticodon binding site; other site 1064539000584 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1064539000585 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1064539000586 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064539000587 Zn2+ binding site [ion binding]; other site 1064539000588 Mg2+ binding site [ion binding]; other site 1064539000589 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1064539000590 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1064539000591 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1064539000592 putative catalytic site [active] 1064539000593 putative phosphate binding site [ion binding]; other site 1064539000594 active site 1064539000595 metal binding site A [ion binding]; metal-binding site 1064539000596 DNA binding site [nucleotide binding] 1064539000597 putative AP binding site [nucleotide binding]; other site 1064539000598 putative metal binding site B [ion binding]; other site 1064539000599 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539000600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539000601 active site 1064539000602 phosphorylation site [posttranslational modification] 1064539000603 intermolecular recognition site; other site 1064539000604 dimerization interface [polypeptide binding]; other site 1064539000605 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539000606 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539000607 metal binding site [ion binding]; metal-binding site 1064539000608 active site 1064539000609 I-site; other site 1064539000610 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1064539000611 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1064539000612 substrate binding site [chemical binding]; other site 1064539000613 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1064539000614 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1064539000615 substrate binding site [chemical binding]; other site 1064539000616 ligand binding site [chemical binding]; other site 1064539000617 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1064539000618 Isochorismatase family; Region: Isochorismatase; pfam00857 1064539000619 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1064539000620 catalytic triad [active] 1064539000621 conserved cis-peptide bond; other site 1064539000622 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1064539000623 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1064539000624 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1064539000625 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1064539000626 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1064539000627 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1064539000628 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1064539000629 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1064539000630 tetramer interface [polypeptide binding]; other site 1064539000631 active site 1064539000632 Mg2+/Mn2+ binding site [ion binding]; other site 1064539000633 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1064539000634 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539000635 Q-loop/lid; other site 1064539000636 ABC transporter signature motif; other site 1064539000637 Walker B; other site 1064539000638 D-loop; other site 1064539000639 H-loop/switch region; other site 1064539000640 potential frameshift: common BLAST hit: gi|374998216|ref|YP_004973715.1| branched chain amino acid ABC transporter ATPase 1064539000641 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539000642 ABC transporter; Region: ABC_tran; pfam00005 1064539000643 Q-loop/lid; other site 1064539000644 ABC transporter signature motif; other site 1064539000645 Walker B; other site 1064539000646 D-loop; other site 1064539000647 H-loop/switch region; other site 1064539000648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539000649 Walker A/P-loop; other site 1064539000650 ATP binding site [chemical binding]; other site 1064539000651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539000652 Walker A/P-loop; other site 1064539000653 ATP binding site [chemical binding]; other site 1064539000654 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539000655 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539000656 TM-ABC transporter signature motif; other site 1064539000657 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539000658 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539000659 TM-ABC transporter signature motif; other site 1064539000660 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539000661 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 1064539000662 putative ligand binding site [chemical binding]; other site 1064539000663 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1064539000664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539000665 DNA-binding site [nucleotide binding]; DNA binding site 1064539000666 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1064539000667 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1064539000668 trimer interface [polypeptide binding]; other site 1064539000669 active site 1064539000670 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1064539000671 dimerization interface [polypeptide binding]; other site 1064539000672 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1064539000673 short chain dehydrogenase; Provisional; Region: PRK06139 1064539000674 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1064539000675 putative NAD(P) binding site [chemical binding]; other site 1064539000676 active site 1064539000677 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1064539000678 CPxP motif; other site 1064539000679 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 1064539000680 Uncharacterized conserved protein [Function unknown]; Region: COG2014 1064539000681 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 1064539000682 Domain of unknown function (DUF364); Region: DUF364; pfam04016 1064539000683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1064539000684 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1064539000685 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1064539000686 dimer interface [polypeptide binding]; other site 1064539000687 putative functional site; other site 1064539000688 putative MPT binding site; other site 1064539000689 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064539000690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539000691 dimer interface [polypeptide binding]; other site 1064539000692 conserved gate region; other site 1064539000693 putative PBP binding loops; other site 1064539000694 ABC-ATPase subunit interface; other site 1064539000695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064539000696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539000697 dimer interface [polypeptide binding]; other site 1064539000698 conserved gate region; other site 1064539000699 putative PBP binding loops; other site 1064539000700 ABC-ATPase subunit interface; other site 1064539000701 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539000702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539000703 substrate binding pocket [chemical binding]; other site 1064539000704 membrane-bound complex binding site; other site 1064539000705 hinge residues; other site 1064539000706 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1064539000707 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064539000708 Walker A/P-loop; other site 1064539000709 ATP binding site [chemical binding]; other site 1064539000710 Q-loop/lid; other site 1064539000711 ABC transporter signature motif; other site 1064539000712 Walker B; other site 1064539000713 D-loop; other site 1064539000714 H-loop/switch region; other site 1064539000715 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1064539000716 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1064539000717 putative ligand binding site [chemical binding]; other site 1064539000718 NAD binding site [chemical binding]; other site 1064539000719 catalytic site [active] 1064539000720 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 1064539000721 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 1064539000722 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1064539000723 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064539000724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064539000725 DNA binding site [nucleotide binding] 1064539000726 domain linker motif; other site 1064539000727 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539000728 Dehydratase family; Region: ILVD_EDD; cl00340 1064539000729 Dehydratase family; Region: ILVD_EDD; cl00340 1064539000730 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1064539000731 AAA domain; Region: AAA_33; pfam13671 1064539000732 ATP-binding site [chemical binding]; other site 1064539000733 Gluconate-6-phosphate binding site [chemical binding]; other site 1064539000734 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064539000735 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1064539000736 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1064539000737 putative dimerization interface [polypeptide binding]; other site 1064539000738 putative ligand binding site [chemical binding]; other site 1064539000739 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064539000740 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1064539000741 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1064539000742 enoyl-CoA hydratase; Provisional; Region: PRK07511 1064539000743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539000744 substrate binding site [chemical binding]; other site 1064539000745 oxyanion hole (OAH) forming residues; other site 1064539000746 trimer interface [polypeptide binding]; other site 1064539000747 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1064539000748 CoenzymeA binding site [chemical binding]; other site 1064539000749 subunit interaction site [polypeptide binding]; other site 1064539000750 PHB binding site; other site 1064539000751 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1064539000752 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539000753 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064539000754 protein binding site [polypeptide binding]; other site 1064539000755 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1064539000756 BON domain; Region: BON; pfam04972 1064539000757 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064539000758 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 1064539000759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539000760 putative PBP binding loops; other site 1064539000761 ABC-ATPase subunit interface; other site 1064539000762 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1064539000763 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1064539000764 Walker A/P-loop; other site 1064539000765 ATP binding site [chemical binding]; other site 1064539000766 Q-loop/lid; other site 1064539000767 ABC transporter signature motif; other site 1064539000768 Walker B; other site 1064539000769 D-loop; other site 1064539000770 H-loop/switch region; other site 1064539000771 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1064539000772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539000773 ABC-ATPase subunit interface; other site 1064539000774 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1064539000775 ferrochelatase; Reviewed; Region: hemH; PRK00035 1064539000776 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1064539000777 C-terminal domain interface [polypeptide binding]; other site 1064539000778 active site 1064539000779 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1064539000780 active site 1064539000781 N-terminal domain interface [polypeptide binding]; other site 1064539000782 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064539000783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539000784 DNA-binding site [nucleotide binding]; DNA binding site 1064539000785 FCD domain; Region: FCD; pfam07729 1064539000786 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1064539000787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539000788 Walker A/P-loop; other site 1064539000789 ATP binding site [chemical binding]; other site 1064539000790 Q-loop/lid; other site 1064539000791 ABC transporter signature motif; other site 1064539000792 Walker B; other site 1064539000793 D-loop; other site 1064539000794 H-loop/switch region; other site 1064539000795 TOBE domain; Region: TOBE_2; pfam08402 1064539000796 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1064539000797 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539000798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539000799 dimer interface [polypeptide binding]; other site 1064539000800 conserved gate region; other site 1064539000801 putative PBP binding loops; other site 1064539000802 ABC-ATPase subunit interface; other site 1064539000803 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064539000804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539000805 dimer interface [polypeptide binding]; other site 1064539000806 conserved gate region; other site 1064539000807 putative PBP binding loops; other site 1064539000808 ABC-ATPase subunit interface; other site 1064539000809 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1064539000810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539000811 Coenzyme A binding pocket [chemical binding]; other site 1064539000812 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1064539000813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539000814 TPR motif; other site 1064539000815 TPR repeat; Region: TPR_11; pfam13414 1064539000816 binding surface 1064539000817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539000818 binding surface 1064539000819 TPR motif; other site 1064539000820 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1064539000821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539000822 binding surface 1064539000823 TPR motif; other site 1064539000824 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1064539000825 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539000826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1064539000827 active site 1064539000828 phosphorylation site [posttranslational modification] 1064539000829 intermolecular recognition site; other site 1064539000830 dimerization interface [polypeptide binding]; other site 1064539000831 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1064539000832 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539000833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539000834 active site 1064539000835 phosphorylation site [posttranslational modification] 1064539000836 intermolecular recognition site; other site 1064539000837 dimerization interface [polypeptide binding]; other site 1064539000838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539000839 DNA binding site [nucleotide binding] 1064539000840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539000841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539000842 dimer interface [polypeptide binding]; other site 1064539000843 phosphorylation site [posttranslational modification] 1064539000844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539000845 ATP binding site [chemical binding]; other site 1064539000846 Mg2+ binding site [ion binding]; other site 1064539000847 G-X-G motif; other site 1064539000848 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539000849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539000850 active site 1064539000851 phosphorylation site [posttranslational modification] 1064539000852 intermolecular recognition site; other site 1064539000853 dimerization interface [polypeptide binding]; other site 1064539000854 hypothetical protein; Provisional; Region: PRK07206 1064539000855 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1064539000856 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539000857 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539000858 dimerization interface [polypeptide binding]; other site 1064539000859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539000860 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539000861 putative substrate translocation pore; other site 1064539000862 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539000863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539000864 active site 1064539000865 phosphorylation site [posttranslational modification] 1064539000866 intermolecular recognition site; other site 1064539000867 dimerization interface [polypeptide binding]; other site 1064539000868 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1064539000869 Homeodomain-like domain; Region: HTH_23; pfam13384 1064539000870 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1064539000871 DNA protecting protein DprA; Region: dprA; TIGR00732 1064539000872 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1064539000873 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1064539000874 active site 1064539000875 interdomain interaction site; other site 1064539000876 putative metal-binding site [ion binding]; other site 1064539000877 nucleotide binding site [chemical binding]; other site 1064539000878 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1064539000879 domain I; other site 1064539000880 DNA binding groove [nucleotide binding] 1064539000881 phosphate binding site [ion binding]; other site 1064539000882 domain II; other site 1064539000883 domain III; other site 1064539000884 nucleotide binding site [chemical binding]; other site 1064539000885 catalytic site [active] 1064539000886 domain IV; other site 1064539000887 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1064539000888 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1064539000889 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1064539000890 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1064539000891 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1064539000892 Pleckstrin homology-like domain; Region: PH-like; cl17171 1064539000893 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539000894 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539000895 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1064539000896 DctM-like transporters; Region: DctM; pfam06808 1064539000897 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1064539000898 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1064539000899 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1064539000900 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1064539000901 putative active site [active] 1064539000902 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1064539000903 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1064539000904 FMN binding site [chemical binding]; other site 1064539000905 active site 1064539000906 catalytic residues [active] 1064539000907 substrate binding site [chemical binding]; other site 1064539000908 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 1064539000909 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1064539000910 catalytic residues [active] 1064539000911 dimer interface [polypeptide binding]; other site 1064539000912 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1064539000913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539000914 putative substrate translocation pore; other site 1064539000915 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1064539000916 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1064539000917 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064539000918 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1064539000919 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1064539000920 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1064539000921 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1064539000922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1064539000923 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1064539000924 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 1064539000925 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1064539000926 ligand binding site [chemical binding]; other site 1064539000927 NAD binding site [chemical binding]; other site 1064539000928 catalytic site [active] 1064539000929 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1064539000930 threonine synthase; Validated; Region: PRK08197 1064539000931 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1064539000932 homodimer interface [polypeptide binding]; other site 1064539000933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539000934 catalytic residue [active] 1064539000935 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539000936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539000937 dimer interface [polypeptide binding]; other site 1064539000938 conserved gate region; other site 1064539000939 putative PBP binding loops; other site 1064539000940 ABC-ATPase subunit interface; other site 1064539000941 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539000942 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539000943 Walker A/P-loop; other site 1064539000944 ATP binding site [chemical binding]; other site 1064539000945 Q-loop/lid; other site 1064539000946 ABC transporter signature motif; other site 1064539000947 Walker B; other site 1064539000948 D-loop; other site 1064539000949 H-loop/switch region; other site 1064539000950 NMT1-like family; Region: NMT1_2; pfam13379 1064539000951 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1064539000952 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1064539000953 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1064539000954 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1064539000955 NMT1-like family; Region: NMT1_2; pfam13379 1064539000956 GMP synthase; Reviewed; Region: guaA; PRK00074 1064539000957 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1064539000958 AMP/PPi binding site [chemical binding]; other site 1064539000959 candidate oxyanion hole; other site 1064539000960 catalytic triad [active] 1064539000961 potential glutamine specificity residues [chemical binding]; other site 1064539000962 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1064539000963 ATP Binding subdomain [chemical binding]; other site 1064539000964 Ligand Binding sites [chemical binding]; other site 1064539000965 Dimerization subdomain; other site 1064539000966 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1064539000967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539000968 Coenzyme A binding pocket [chemical binding]; other site 1064539000969 Purine nucleoside permease (NUP); Region: NUP; cl17832 1064539000970 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539000971 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539000972 MltA specific insert domain; Region: MltA; smart00925 1064539000973 3D domain; Region: 3D; pfam06725 1064539000974 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1064539000975 Coenzyme A binding pocket [chemical binding]; other site 1064539000976 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1064539000977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1064539000978 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1064539000979 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1064539000980 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1064539000981 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1064539000982 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1064539000983 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1064539000984 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1064539000985 active site 1064539000986 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1064539000987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539000988 S-adenosylmethionine binding site [chemical binding]; other site 1064539000989 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1064539000990 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1064539000991 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064539000992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539000993 DNA-binding site [nucleotide binding]; DNA binding site 1064539000994 FCD domain; Region: FCD; pfam07729 1064539000995 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1064539000996 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1064539000997 putative NAD(P) binding site [chemical binding]; other site 1064539000998 catalytic Zn binding site [ion binding]; other site 1064539000999 structural Zn binding site [ion binding]; other site 1064539001000 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539001001 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1064539001002 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1064539001003 DctM-like transporters; Region: DctM; pfam06808 1064539001004 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1064539001005 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1064539001006 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1064539001007 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1064539001008 altronate oxidoreductase; Provisional; Region: PRK03643 1064539001009 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1064539001010 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1064539001011 ribonuclease R; Region: RNase_R; TIGR02063 1064539001012 RNB domain; Region: RNB; pfam00773 1064539001013 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1064539001014 RNA binding site [nucleotide binding]; other site 1064539001015 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1064539001016 protein binding site [polypeptide binding]; other site 1064539001017 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1064539001018 Catalytic dyad [active] 1064539001019 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1064539001020 response regulator PleD; Reviewed; Region: pleD; PRK09581 1064539001021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001022 active site 1064539001023 phosphorylation site [posttranslational modification] 1064539001024 intermolecular recognition site; other site 1064539001025 dimerization interface [polypeptide binding]; other site 1064539001026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001027 active site 1064539001028 phosphorylation site [posttranslational modification] 1064539001029 intermolecular recognition site; other site 1064539001030 dimerization interface [polypeptide binding]; other site 1064539001031 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539001032 metal binding site [ion binding]; metal-binding site 1064539001033 active site 1064539001034 I-site; other site 1064539001035 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539001036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001037 active site 1064539001038 phosphorylation site [posttranslational modification] 1064539001039 intermolecular recognition site; other site 1064539001040 dimerization interface [polypeptide binding]; other site 1064539001041 GAF domain; Region: GAF; pfam01590 1064539001042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539001043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539001044 dimer interface [polypeptide binding]; other site 1064539001045 phosphorylation site [posttranslational modification] 1064539001046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539001047 ATP binding site [chemical binding]; other site 1064539001048 Mg2+ binding site [ion binding]; other site 1064539001049 G-X-G motif; other site 1064539001050 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539001051 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539001052 metal binding site [ion binding]; metal-binding site 1064539001053 active site 1064539001054 I-site; other site 1064539001055 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1064539001056 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1064539001057 dimerization interface [polypeptide binding]; other site 1064539001058 ligand binding site [chemical binding]; other site 1064539001059 NADP binding site [chemical binding]; other site 1064539001060 catalytic site [active] 1064539001061 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 1064539001062 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1064539001063 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1064539001064 dimer interface [polypeptide binding]; other site 1064539001065 anticodon binding site; other site 1064539001066 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1064539001067 homodimer interface [polypeptide binding]; other site 1064539001068 motif 1; other site 1064539001069 active site 1064539001070 motif 2; other site 1064539001071 GAD domain; Region: GAD; pfam02938 1064539001072 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1064539001073 active site 1064539001074 motif 3; other site 1064539001075 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1064539001076 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1064539001077 catalytic site [active] 1064539001078 putative active site [active] 1064539001079 putative substrate binding site [chemical binding]; other site 1064539001080 HRDC domain; Region: HRDC; pfam00570 1064539001081 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1064539001082 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539001083 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539001084 polyphosphate kinase; Provisional; Region: PRK05443 1064539001085 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1064539001086 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1064539001087 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1064539001088 putative domain interface [polypeptide binding]; other site 1064539001089 putative active site [active] 1064539001090 catalytic site [active] 1064539001091 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1064539001092 putative domain interface [polypeptide binding]; other site 1064539001093 putative active site [active] 1064539001094 catalytic site [active] 1064539001095 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064539001096 catalytic core [active] 1064539001097 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1064539001098 putative active site [active] 1064539001099 putative metal binding residues [ion binding]; other site 1064539001100 signature motif; other site 1064539001101 putative triphosphate binding site [ion binding]; other site 1064539001102 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1064539001103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539001104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539001105 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 1064539001106 putative substrate binding pocket [chemical binding]; other site 1064539001107 putative dimerization interface [polypeptide binding]; other site 1064539001108 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1064539001109 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1064539001110 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1064539001111 short chain dehydrogenase; Provisional; Region: PRK06125 1064539001112 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1064539001113 putative NAD(P) binding site [chemical binding]; other site 1064539001114 putative active site [active] 1064539001115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1064539001116 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1064539001117 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1064539001118 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1064539001119 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1064539001120 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1064539001121 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1064539001122 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1064539001123 dimerization interface [polypeptide binding]; other site 1064539001124 putative ATP binding site [chemical binding]; other site 1064539001125 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1064539001126 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1064539001127 active site 1064539001128 substrate binding site [chemical binding]; other site 1064539001129 cosubstrate binding site; other site 1064539001130 catalytic site [active] 1064539001131 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 1064539001132 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1064539001133 active site 1064539001134 multimer interface [polypeptide binding]; other site 1064539001135 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1064539001136 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064539001137 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064539001138 ABC transporter; Region: ABC_tran_2; pfam12848 1064539001139 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064539001140 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1064539001141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539001142 S-adenosylmethionine binding site [chemical binding]; other site 1064539001143 short chain dehydrogenase; Provisional; Region: PRK07024 1064539001144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539001145 NAD(P) binding site [chemical binding]; other site 1064539001146 active site 1064539001147 hypothetical protein; Provisional; Region: PRK11820 1064539001148 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1064539001149 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1064539001150 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1064539001151 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1064539001152 catalytic site [active] 1064539001153 G-X2-G-X-G-K; other site 1064539001154 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1064539001155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539001156 S-adenosylmethionine binding site [chemical binding]; other site 1064539001157 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1064539001158 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064539001159 Sel1-like repeats; Region: SEL1; smart00671 1064539001160 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1064539001161 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539001162 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539001163 catalytic residue [active] 1064539001164 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539001165 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539001166 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 1064539001167 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1064539001168 SurA N-terminal domain; Region: SurA_N; pfam09312 1064539001169 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1064539001170 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1064539001171 Predicted permeases [General function prediction only]; Region: COG0795 1064539001172 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1064539001173 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1064539001174 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1064539001175 interface (dimer of trimers) [polypeptide binding]; other site 1064539001176 Substrate-binding/catalytic site; other site 1064539001177 Zn-binding sites [ion binding]; other site 1064539001178 DNA polymerase III subunit chi; Validated; Region: PRK05728 1064539001179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001180 active site 1064539001181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539001182 phosphorylation site [posttranslational modification] 1064539001183 intermolecular recognition site; other site 1064539001184 dimerization interface [polypeptide binding]; other site 1064539001185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539001186 dimer interface [polypeptide binding]; other site 1064539001187 phosphorylation site [posttranslational modification] 1064539001188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539001189 ATP binding site [chemical binding]; other site 1064539001190 Mg2+ binding site [ion binding]; other site 1064539001191 G-X-G motif; other site 1064539001192 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539001193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539001194 putative substrate translocation pore; other site 1064539001195 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1064539001196 excinuclease ABC subunit B; Provisional; Region: PRK05298 1064539001197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064539001198 ATP binding site [chemical binding]; other site 1064539001199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539001200 nucleotide binding region [chemical binding]; other site 1064539001201 ATP-binding site [chemical binding]; other site 1064539001202 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1064539001203 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1064539001204 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1064539001205 homodimer interface [polypeptide binding]; other site 1064539001206 substrate-cofactor binding pocket; other site 1064539001207 catalytic residue [active] 1064539001208 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064539001209 MarR family; Region: MarR_2; pfam12802 1064539001210 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539001211 DNA-binding site [nucleotide binding]; DNA binding site 1064539001212 RNA-binding motif; other site 1064539001213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539001214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539001215 dimer interface [polypeptide binding]; other site 1064539001216 phosphorylation site [posttranslational modification] 1064539001217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539001218 ATP binding site [chemical binding]; other site 1064539001219 Mg2+ binding site [ion binding]; other site 1064539001220 G-X-G motif; other site 1064539001221 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539001222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001223 active site 1064539001224 phosphorylation site [posttranslational modification] 1064539001225 intermolecular recognition site; other site 1064539001226 dimerization interface [polypeptide binding]; other site 1064539001227 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1064539001228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001229 active site 1064539001230 phosphorylation site [posttranslational modification] 1064539001231 intermolecular recognition site; other site 1064539001232 dimerization interface [polypeptide binding]; other site 1064539001233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539001234 DNA binding site [nucleotide binding] 1064539001235 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539001236 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539001237 dimerization interface [polypeptide binding]; other site 1064539001238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539001239 dimer interface [polypeptide binding]; other site 1064539001240 phosphorylation site [posttranslational modification] 1064539001241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539001242 ATP binding site [chemical binding]; other site 1064539001243 Mg2+ binding site [ion binding]; other site 1064539001244 G-X-G motif; other site 1064539001245 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1064539001246 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1064539001247 active site 1064539001248 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1064539001249 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064539001250 Ribbon-helix-helix domain; Region: RHH_4; cl01775 1064539001251 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1064539001252 catalytic core [active] 1064539001253 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539001254 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539001255 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539001256 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1064539001257 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 1064539001258 nudix motif; other site 1064539001259 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1064539001260 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1064539001261 DctM-like transporters; Region: DctM; pfam06808 1064539001262 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1064539001263 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1064539001264 S-formylglutathione hydrolase; Region: PLN02442 1064539001265 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1064539001266 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1064539001267 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1064539001268 substrate binding site [chemical binding]; other site 1064539001269 catalytic Zn binding site [ion binding]; other site 1064539001270 NAD binding site [chemical binding]; other site 1064539001271 structural Zn binding site [ion binding]; other site 1064539001272 dimer interface [polypeptide binding]; other site 1064539001273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539001274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539001275 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470 1064539001276 putative effector binding pocket; other site 1064539001277 putative dimerization interface [polypeptide binding]; other site 1064539001278 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539001279 Sulphur transport; Region: Sulf_transp; pfam04143 1064539001280 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1064539001281 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1064539001282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064539001283 Beta-Casp domain; Region: Beta-Casp; cl12567 1064539001284 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1064539001285 Walker A/P-loop; other site 1064539001286 ATP binding site [chemical binding]; other site 1064539001287 ABC transporter; Region: ABC_tran; pfam00005 1064539001288 Q-loop/lid; other site 1064539001289 ABC transporter signature motif; other site 1064539001290 Walker B; other site 1064539001291 potential frameshift: common BLAST hit: gi|339504753|ref|YP_004692173.1| ABC transporter ATP-binding protein 1064539001292 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1064539001293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539001294 H-loop/switch region; other site 1064539001295 TOBE domain; Region: TOBE_2; pfam08402 1064539001296 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404942, 8807793; Product type pt : putative transporter 1064539001297 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404942, 8807793; Product type pt : putative transporter 1064539001298 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064539001299 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1064539001300 Rdx family; Region: Rdx; cl01407 1064539001301 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1064539001302 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1064539001303 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1064539001304 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064539001305 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064539001306 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064539001307 MarR family; Region: MarR; pfam01047 1064539001308 PAS domain; Region: PAS_9; pfam13426 1064539001309 PAS domain; Region: PAS_9; pfam13426 1064539001310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539001311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539001312 dimer interface [polypeptide binding]; other site 1064539001313 phosphorylation site [posttranslational modification] 1064539001314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539001315 ATP binding site [chemical binding]; other site 1064539001316 Mg2+ binding site [ion binding]; other site 1064539001317 G-X-G motif; other site 1064539001318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001319 active site 1064539001320 phosphorylation site [posttranslational modification] 1064539001321 intermolecular recognition site; other site 1064539001322 dimerization interface [polypeptide binding]; other site 1064539001323 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1064539001324 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1064539001325 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1064539001326 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1064539001327 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1064539001328 catalytic site [active] 1064539001329 active site 1064539001330 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1064539001331 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1064539001332 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1064539001333 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1064539001334 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1064539001335 active site 1064539001336 catalytic site [active] 1064539001337 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1064539001338 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539001339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001340 active site 1064539001341 phosphorylation site [posttranslational modification] 1064539001342 intermolecular recognition site; other site 1064539001343 dimerization interface [polypeptide binding]; other site 1064539001344 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1064539001345 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1064539001346 C-terminal domain interface [polypeptide binding]; other site 1064539001347 GSH binding site (G-site) [chemical binding]; other site 1064539001348 dimer interface [polypeptide binding]; other site 1064539001349 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1064539001350 N-terminal domain interface [polypeptide binding]; other site 1064539001351 putative dimer interface [polypeptide binding]; other site 1064539001352 active site 1064539001353 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1064539001354 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1064539001355 NAD binding site [chemical binding]; other site 1064539001356 homotetramer interface [polypeptide binding]; other site 1064539001357 homodimer interface [polypeptide binding]; other site 1064539001358 substrate binding site [chemical binding]; other site 1064539001359 active site 1064539001360 acetoacetyl-CoA synthase; Region: ac_ac_CoA_syn; TIGR01217 1064539001361 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539001362 acyl-activating enzyme (AAE) consensus motif; other site 1064539001363 active site 1064539001364 AMP binding site [chemical binding]; other site 1064539001365 CoA binding site [chemical binding]; other site 1064539001366 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539001367 CoA binding site [chemical binding]; other site 1064539001368 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539001369 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539001370 TM-ABC transporter signature motif; other site 1064539001371 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539001372 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539001373 TM-ABC transporter signature motif; other site 1064539001374 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539001375 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1064539001376 putative ligand binding site [chemical binding]; other site 1064539001377 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539001378 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539001379 Walker A/P-loop; other site 1064539001380 ATP binding site [chemical binding]; other site 1064539001381 Q-loop/lid; other site 1064539001382 ABC transporter signature motif; other site 1064539001383 Walker B; other site 1064539001384 D-loop; other site 1064539001385 H-loop/switch region; other site 1064539001386 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539001387 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539001388 Walker A/P-loop; other site 1064539001389 ATP binding site [chemical binding]; other site 1064539001390 Q-loop/lid; other site 1064539001391 ABC transporter signature motif; other site 1064539001392 Walker B; other site 1064539001393 D-loop; other site 1064539001394 H-loop/switch region; other site 1064539001395 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1064539001396 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1064539001397 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1064539001398 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 1064539001399 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1064539001400 precorrin-3B synthase; Region: CobG; TIGR02435 1064539001401 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1064539001402 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1064539001403 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1064539001404 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539001405 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539001406 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1064539001407 active site 1064539001408 SAM binding site [chemical binding]; other site 1064539001409 homodimer interface [polypeptide binding]; other site 1064539001410 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1064539001411 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1064539001412 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1064539001413 active site 1064539001414 putative homodimer interface [polypeptide binding]; other site 1064539001415 SAM binding site [chemical binding]; other site 1064539001416 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1064539001417 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 1064539001418 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1064539001419 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1064539001420 homodimer interface [polypeptide binding]; other site 1064539001421 active site 1064539001422 SAM binding site [chemical binding]; other site 1064539001423 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1064539001424 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1064539001425 active site 1064539001426 SAM binding site [chemical binding]; other site 1064539001427 homodimer interface [polypeptide binding]; other site 1064539001428 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1064539001429 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1064539001430 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1064539001431 putative FMN binding site [chemical binding]; other site 1064539001432 oxidoreductase; Provisional; Region: PRK12742 1064539001433 classical (c) SDRs; Region: SDR_c; cd05233 1064539001434 NAD(P) binding site [chemical binding]; other site 1064539001435 active site 1064539001436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539001437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539001438 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1064539001439 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1064539001440 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1064539001441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539001442 DNA-binding site [nucleotide binding]; DNA binding site 1064539001443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539001444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539001445 homodimer interface [polypeptide binding]; other site 1064539001446 catalytic residue [active] 1064539001447 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1064539001448 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1064539001449 active site 1064539001450 metal binding site [ion binding]; metal-binding site 1064539001451 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1064539001452 PAS domain S-box; Region: sensory_box; TIGR00229 1064539001453 PAS domain; Region: PAS; smart00091 1064539001454 putative active site [active] 1064539001455 heme pocket [chemical binding]; other site 1064539001456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539001457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539001458 ATP binding site [chemical binding]; other site 1064539001459 Mg2+ binding site [ion binding]; other site 1064539001460 G-X-G motif; other site 1064539001461 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 1064539001462 potential frameshift: common BLAST hit: gi|288960287|ref|YP_003450627.1| TPR domain-containing protein 1064539001463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001464 TPR motif; other site 1064539001465 binding surface 1064539001466 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539001467 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1064539001468 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1064539001469 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1064539001470 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064539001471 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 1064539001472 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064539001473 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1064539001474 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1064539001475 Flagellar protein FlaF; Region: FlaF; pfam07309 1064539001476 Predicted permeases [General function prediction only]; Region: COG0795 1064539001477 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1064539001478 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1064539001479 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1064539001480 putative active site [active] 1064539001481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539001482 dimerization interface [polypeptide binding]; other site 1064539001483 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539001484 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539001485 dimer interface [polypeptide binding]; other site 1064539001486 putative CheW interface [polypeptide binding]; other site 1064539001487 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539001488 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539001489 Walker A/P-loop; other site 1064539001490 ATP binding site [chemical binding]; other site 1064539001491 Q-loop/lid; other site 1064539001492 ABC transporter signature motif; other site 1064539001493 Walker B; other site 1064539001494 D-loop; other site 1064539001495 H-loop/switch region; other site 1064539001496 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539001497 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539001498 TM-ABC transporter signature motif; other site 1064539001499 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539001500 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539001501 TM-ABC transporter signature motif; other site 1064539001502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1064539001503 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064539001504 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539001505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001506 TPR motif; other site 1064539001507 binding surface 1064539001508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539001509 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539001510 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539001511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001512 binding surface 1064539001513 TPR repeat; Region: TPR_11; pfam13414 1064539001514 TPR motif; other site 1064539001515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001516 binding surface 1064539001517 TPR motif; other site 1064539001518 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539001519 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1064539001520 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1064539001521 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1064539001522 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1064539001523 minor groove reading motif; other site 1064539001524 helix-hairpin-helix signature motif; other site 1064539001525 substrate binding pocket [chemical binding]; other site 1064539001526 active site 1064539001527 Cupin domain; Region: Cupin_2; pfam07883 1064539001528 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 1064539001529 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1064539001530 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1064539001531 beta-galactosidase; Region: BGL; TIGR03356 1064539001532 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1064539001533 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1064539001534 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1064539001535 Ligand binding site [chemical binding]; other site 1064539001536 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1064539001537 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 1064539001538 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1064539001539 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1064539001540 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 1064539001541 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1064539001542 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1064539001543 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1064539001544 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1064539001545 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1064539001546 catalytic residues [active] 1064539001547 argininosuccinate lyase; Provisional; Region: PRK00855 1064539001548 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1064539001549 active sites [active] 1064539001550 tetramer interface [polypeptide binding]; other site 1064539001551 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1064539001552 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1064539001553 active site 1064539001554 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064539001555 substrate binding site [chemical binding]; other site 1064539001556 catalytic residues [active] 1064539001557 dimer interface [polypeptide binding]; other site 1064539001558 Hemerythrin; Region: Hemerythrin; cd12107 1064539001559 Fe binding site [ion binding]; other site 1064539001560 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 1064539001561 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1064539001562 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1064539001563 Domain of unknown function DUF21; Region: DUF21; pfam01595 1064539001564 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1064539001565 Transporter associated domain; Region: CorC_HlyC; smart01091 1064539001566 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1064539001567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539001568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539001569 dimer interface [polypeptide binding]; other site 1064539001570 phosphorylation site [posttranslational modification] 1064539001571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539001572 ATP binding site [chemical binding]; other site 1064539001573 Mg2+ binding site [ion binding]; other site 1064539001574 G-X-G motif; other site 1064539001575 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1064539001576 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1064539001577 B12 binding site [chemical binding]; other site 1064539001578 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539001579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001580 active site 1064539001581 phosphorylation site [posttranslational modification] 1064539001582 intermolecular recognition site; other site 1064539001583 dimerization interface [polypeptide binding]; other site 1064539001584 HD domain; Region: HD_3; cl17350 1064539001585 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1064539001586 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1064539001587 TPP-binding site; other site 1064539001588 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1064539001589 PYR/PP interface [polypeptide binding]; other site 1064539001590 dimer interface [polypeptide binding]; other site 1064539001591 TPP binding site [chemical binding]; other site 1064539001592 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064539001593 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1064539001594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539001595 FeS/SAM binding site; other site 1064539001596 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1064539001597 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1064539001598 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 1064539001599 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1064539001600 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1064539001601 Active site cavity [active] 1064539001602 catalytic acid [active] 1064539001603 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1064539001604 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 1064539001605 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1064539001606 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1064539001607 putative NADP binding site [chemical binding]; other site 1064539001608 putative substrate binding site [chemical binding]; other site 1064539001609 active site 1064539001610 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1064539001611 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1064539001612 putative active site pocket [active] 1064539001613 dimerization interface [polypeptide binding]; other site 1064539001614 putative catalytic residue [active] 1064539001615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 1064539001616 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 1064539001617 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1064539001618 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1064539001619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1064539001620 Predicted membrane protein [Function unknown]; Region: COG3766 1064539001621 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1064539001622 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1064539001623 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1064539001624 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1064539001625 substrate binding site [chemical binding]; other site 1064539001626 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1064539001627 substrate binding site [chemical binding]; other site 1064539001628 ligand binding site [chemical binding]; other site 1064539001629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539001630 non-specific DNA binding site [nucleotide binding]; other site 1064539001631 salt bridge; other site 1064539001632 sequence-specific DNA binding site [nucleotide binding]; other site 1064539001633 Helix-turn-helix domain; Region: HTH_18; pfam12833 1064539001634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539001635 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539001636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539001637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539001638 putative substrate translocation pore; other site 1064539001639 flavodoxin FldA; Validated; Region: PRK09267 1064539001640 Protein of unknown function (DUF2023); Region: DUF2023; pfam09633 1064539001641 AAA domain; Region: AAA_33; pfam13671 1064539001642 AAA domain; Region: AAA_17; pfam13207 1064539001643 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1064539001644 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1064539001645 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1064539001646 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1064539001647 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539001648 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539001649 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1064539001650 Uncharacterized conserved protein [Function unknown]; Region: COG1944 1064539001651 YcaO-like family; Region: YcaO; pfam02624 1064539001652 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1064539001653 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539001654 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539001655 ligand binding site [chemical binding]; other site 1064539001656 flexible hinge region; other site 1064539001657 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1064539001658 putative switch regulator; other site 1064539001659 non-specific DNA interactions [nucleotide binding]; other site 1064539001660 DNA binding site [nucleotide binding] 1064539001661 sequence specific DNA binding site [nucleotide binding]; other site 1064539001662 putative cAMP binding site [chemical binding]; other site 1064539001663 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1064539001664 PAS domain S-box; Region: sensory_box; TIGR00229 1064539001665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539001666 putative active site [active] 1064539001667 heme pocket [chemical binding]; other site 1064539001668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539001669 dimer interface [polypeptide binding]; other site 1064539001670 phosphorylation site [posttranslational modification] 1064539001671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539001672 ATP binding site [chemical binding]; other site 1064539001673 Mg2+ binding site [ion binding]; other site 1064539001674 G-X-G motif; other site 1064539001675 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539001676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001677 active site 1064539001678 phosphorylation site [posttranslational modification] 1064539001679 intermolecular recognition site; other site 1064539001680 dimerization interface [polypeptide binding]; other site 1064539001681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539001682 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539001683 NAD(P) binding site [chemical binding]; other site 1064539001684 active site 1064539001685 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539001686 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539001687 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539001688 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539001689 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539001690 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064539001691 dimerization interface [polypeptide binding]; other site 1064539001692 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1064539001693 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539001694 dimerization interface [polypeptide binding]; other site 1064539001695 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539001696 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539001697 metal binding site [ion binding]; metal-binding site 1064539001698 active site 1064539001699 I-site; other site 1064539001700 SlyX; Region: SlyX; pfam04102 1064539001701 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1064539001702 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1064539001703 metal binding site 2 [ion binding]; metal-binding site 1064539001704 putative DNA binding helix; other site 1064539001705 metal binding site 1 [ion binding]; metal-binding site 1064539001706 dimer interface [polypeptide binding]; other site 1064539001707 structural Zn2+ binding site [ion binding]; other site 1064539001708 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1064539001709 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1064539001710 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1064539001711 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1064539001712 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1064539001713 active site 1064539001714 metal binding site [ion binding]; metal-binding site 1064539001715 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1064539001716 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539001717 dimerization interface [polypeptide binding]; other site 1064539001718 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539001719 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539001720 dimer interface [polypeptide binding]; other site 1064539001721 putative CheW interface [polypeptide binding]; other site 1064539001722 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1064539001723 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539001724 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1064539001725 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539001726 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1064539001727 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1064539001728 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 1064539001729 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1064539001730 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539001731 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539001732 ligand binding site [chemical binding]; other site 1064539001733 flexible hinge region; other site 1064539001734 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1064539001735 non-specific DNA interactions [nucleotide binding]; other site 1064539001736 DNA binding site [nucleotide binding] 1064539001737 sequence specific DNA binding site [nucleotide binding]; other site 1064539001738 putative cAMP binding site [chemical binding]; other site 1064539001739 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1064539001740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064539001741 ATP binding site [chemical binding]; other site 1064539001742 putative Mg++ binding site [ion binding]; other site 1064539001743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539001744 nucleotide binding region [chemical binding]; other site 1064539001745 ATP-binding site [chemical binding]; other site 1064539001746 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 1064539001747 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1064539001748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064539001749 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1064539001750 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1064539001751 Fe-S cluster binding site [ion binding]; other site 1064539001752 active site 1064539001753 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1064539001754 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539001755 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539001756 catalytic residue [active] 1064539001757 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1064539001758 MPT binding site; other site 1064539001759 trimer interface [polypeptide binding]; other site 1064539001760 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1064539001761 Evidence 4 : Homologs of previously reported genes of unknown function 1064539001762 Evidence 4 : Homologs of previously reported genes of unknown function 1064539001763 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 1064539001764 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1064539001765 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1064539001766 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1064539001767 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1064539001768 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1064539001769 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1064539001770 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1064539001771 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1064539001772 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1064539001773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539001774 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1064539001775 putative dimerization interface [polypeptide binding]; other site 1064539001776 PAS fold; Region: PAS_4; pfam08448 1064539001777 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1064539001778 PAS domain S-box; Region: sensory_box; TIGR00229 1064539001779 PAS domain; Region: PAS; smart00091 1064539001780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1064539001781 HWE histidine kinase; Region: HWE_HK; smart00911 1064539001782 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539001783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001784 active site 1064539001785 phosphorylation site [posttranslational modification] 1064539001786 intermolecular recognition site; other site 1064539001787 dimerization interface [polypeptide binding]; other site 1064539001788 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1064539001789 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064539001790 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1064539001791 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1064539001792 active site 2 [active] 1064539001793 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1064539001794 active site 2 [active] 1064539001795 active site 1 [active] 1064539001796 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1064539001797 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539001798 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064539001799 active site 1064539001800 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539001801 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1064539001802 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1064539001803 TPR repeat; Region: TPR_11; pfam13414 1064539001804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001805 binding surface 1064539001806 TPR motif; other site 1064539001807 TPR repeat; Region: TPR_11; pfam13414 1064539001808 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539001809 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539001810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001811 TPR motif; other site 1064539001812 binding surface 1064539001813 TPR repeat; Region: TPR_11; pfam13414 1064539001814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001815 binding surface 1064539001816 TPR motif; other site 1064539001817 TPR repeat; Region: TPR_11; pfam13414 1064539001818 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1064539001819 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1064539001820 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539001821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001822 TPR motif; other site 1064539001823 binding surface 1064539001824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001825 TPR repeat; Region: TPR_11; pfam13414 1064539001826 binding surface 1064539001827 TPR motif; other site 1064539001828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539001829 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539001830 TPR repeat; Region: TPR_11; pfam13414 1064539001831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001832 binding surface 1064539001833 TPR motif; other site 1064539001834 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539001835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539001836 binding surface 1064539001837 TPR motif; other site 1064539001838 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1064539001839 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539001840 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539001841 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 1064539001842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001843 binding surface 1064539001844 TPR repeat; Region: TPR_11; pfam13414 1064539001845 TPR motif; other site 1064539001846 TPR repeat; Region: TPR_11; pfam13414 1064539001847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001848 binding surface 1064539001849 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539001850 TPR motif; other site 1064539001851 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539001852 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539001853 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1064539001854 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1064539001855 active site 1064539001856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539001857 binding surface 1064539001858 TPR motif; other site 1064539001859 TPR repeat; Region: TPR_11; pfam13414 1064539001860 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 1064539001861 GDP-Fucose binding site [chemical binding]; other site 1064539001862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001863 binding surface 1064539001864 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1064539001865 TPR motif; other site 1064539001866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001867 binding surface 1064539001868 TPR motif; other site 1064539001869 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539001870 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539001871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001872 binding surface 1064539001873 TPR motif; other site 1064539001874 TPR repeat; Region: TPR_11; pfam13414 1064539001875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001876 binding surface 1064539001877 TPR motif; other site 1064539001878 TPR repeat; Region: TPR_11; pfam13414 1064539001879 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 1064539001880 GDP-Fucose binding site [chemical binding]; other site 1064539001881 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1064539001882 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1064539001883 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1064539001884 active site 1064539001885 HIGH motif; other site 1064539001886 dimer interface [polypeptide binding]; other site 1064539001887 KMSKS motif; other site 1064539001888 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539001889 dimerization interface [polypeptide binding]; other site 1064539001890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539001891 PAS domain; Region: PAS_9; pfam13426 1064539001892 putative active site [active] 1064539001893 heme pocket [chemical binding]; other site 1064539001894 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539001895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539001896 putative active site [active] 1064539001897 heme pocket [chemical binding]; other site 1064539001898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539001899 dimer interface [polypeptide binding]; other site 1064539001900 phosphorylation site [posttranslational modification] 1064539001901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539001902 ATP binding site [chemical binding]; other site 1064539001903 Mg2+ binding site [ion binding]; other site 1064539001904 G-X-G motif; other site 1064539001905 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539001906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001907 active site 1064539001908 phosphorylation site [posttranslational modification] 1064539001909 intermolecular recognition site; other site 1064539001910 dimerization interface [polypeptide binding]; other site 1064539001911 putative aminotransferase; Provisional; Region: PRK09105 1064539001912 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1064539001913 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 1064539001914 putative active site pocket [active] 1064539001915 metal binding site [ion binding]; metal-binding site 1064539001916 cell density-dependent motility repressor; Provisional; Region: PRK10082 1064539001917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539001918 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1064539001919 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1064539001920 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1064539001921 C-terminal domain interface [polypeptide binding]; other site 1064539001922 GSH binding site (G-site) [chemical binding]; other site 1064539001923 dimer interface [polypeptide binding]; other site 1064539001924 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1064539001925 dimer interface [polypeptide binding]; other site 1064539001926 N-terminal domain interface [polypeptide binding]; other site 1064539001927 substrate binding pocket (H-site) [chemical binding]; other site 1064539001928 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1064539001929 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1064539001930 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1064539001931 Transmembrane secretion effector; Region: MFS_3; pfam05977 1064539001932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539001933 Predicted membrane protein [Function unknown]; Region: COG2259 1064539001934 potential frameshift: common BLAST hit: gi|334343187|ref|YP_004555791.1| amidohydrolase 3 1064539001935 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1064539001936 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1064539001937 active site 1064539001938 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1064539001939 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1064539001940 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1064539001941 Isochorismatase family; Region: Isochorismatase; pfam00857 1064539001942 catalytic triad [active] 1064539001943 dimer interface [polypeptide binding]; other site 1064539001944 conserved cis-peptide bond; other site 1064539001945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539001946 ATP binding site [chemical binding]; other site 1064539001947 Mg2+ binding site [ion binding]; other site 1064539001948 G-X-G motif; other site 1064539001949 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1064539001950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539001951 active site 1064539001952 phosphorylation site [posttranslational modification] 1064539001953 intermolecular recognition site; other site 1064539001954 dimerization interface [polypeptide binding]; other site 1064539001955 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539001956 DNA binding residues [nucleotide binding] 1064539001957 dimerization interface [polypeptide binding]; other site 1064539001958 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1064539001959 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1064539001960 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539001961 dimerization interface [polypeptide binding]; other site 1064539001962 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539001963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539001964 metal binding site [ion binding]; metal-binding site 1064539001965 active site 1064539001966 I-site; other site 1064539001967 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1064539001968 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1064539001969 G1 box; other site 1064539001970 GTP/Mg2+ binding site [chemical binding]; other site 1064539001971 Switch I region; other site 1064539001972 G2 box; other site 1064539001973 G3 box; other site 1064539001974 Switch II region; other site 1064539001975 G4 box; other site 1064539001976 G5 box; other site 1064539001977 Nucleoside recognition; Region: Gate; pfam07670 1064539001978 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1064539001979 Nucleoside recognition; Region: Gate; pfam07670 1064539001980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539001981 TPR motif; other site 1064539001982 binding surface 1064539001983 Tetratricopeptide repeat; Region: TPR_9; pfam13371 1064539001984 FeoA domain; Region: FeoA; pfam04023 1064539001985 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1064539001986 putative NAD(P) binding site [chemical binding]; other site 1064539001987 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1064539001988 DNA polymerase III subunit beta; Validated; Region: PRK05643 1064539001989 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1064539001990 putative DNA binding surface [nucleotide binding]; other site 1064539001991 dimer interface [polypeptide binding]; other site 1064539001992 beta-clamp/clamp loader binding surface; other site 1064539001993 beta-clamp/translesion DNA polymerase binding surface; other site 1064539001994 recombination protein F; Reviewed; Region: recF; PRK00064 1064539001995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539001996 Walker A/P-loop; other site 1064539001997 ATP binding site [chemical binding]; other site 1064539001998 Q-loop/lid; other site 1064539001999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539002000 ABC transporter signature motif; other site 1064539002001 Walker B; other site 1064539002002 D-loop; other site 1064539002003 H-loop/switch region; other site 1064539002004 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1064539002005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539002006 Mg2+ binding site [ion binding]; other site 1064539002007 G-X-G motif; other site 1064539002008 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1064539002009 anchoring element; other site 1064539002010 dimer interface [polypeptide binding]; other site 1064539002011 ATP binding site [chemical binding]; other site 1064539002012 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1064539002013 active site 1064539002014 putative metal-binding site [ion binding]; other site 1064539002015 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1064539002016 Homeodomain-like domain; Region: HTH_23; pfam13384 1064539002017 Winged helix-turn helix; Region: HTH_29; pfam13551 1064539002018 Homeodomain-like domain; Region: HTH_32; pfam13565 1064539002019 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1064539002020 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1064539002021 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1064539002022 putative active site [active] 1064539002023 putative metal-binding site [ion binding]; other site 1064539002024 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1064539002025 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1064539002026 active site 1064539002027 metal binding site [ion binding]; metal-binding site 1064539002028 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539002029 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1064539002030 putative catalytic site [active] 1064539002031 putative metal binding site [ion binding]; other site 1064539002032 putative phosphate binding site [ion binding]; other site 1064539002033 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1064539002034 WD domain, G-beta repeat; Region: WD40; pfam00400 1064539002035 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539002036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539002037 ATP binding site [chemical binding]; other site 1064539002038 G-X-G motif; other site 1064539002039 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1064539002040 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1064539002041 putative ADP-binding pocket [chemical binding]; other site 1064539002042 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1064539002043 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1064539002044 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1064539002045 Helix-hairpin-helix motif; Region: HHH; pfam00633 1064539002046 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1064539002047 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1064539002048 substrate binding site [chemical binding]; other site 1064539002049 PAS fold; Region: PAS_4; pfam08448 1064539002050 GAF domain; Region: GAF_3; pfam13492 1064539002051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539002052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539002053 dimer interface [polypeptide binding]; other site 1064539002054 phosphorylation site [posttranslational modification] 1064539002055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539002056 ATP binding site [chemical binding]; other site 1064539002057 Mg2+ binding site [ion binding]; other site 1064539002058 G-X-G motif; other site 1064539002059 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539002060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539002061 active site 1064539002062 phosphorylation site [posttranslational modification] 1064539002063 intermolecular recognition site; other site 1064539002064 dimerization interface [polypeptide binding]; other site 1064539002065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1064539002066 PAS fold; Region: PAS_3; pfam08447 1064539002067 putative active site [active] 1064539002068 heme pocket [chemical binding]; other site 1064539002069 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539002070 PAS fold; Region: PAS_3; pfam08447 1064539002071 putative active site [active] 1064539002072 heme pocket [chemical binding]; other site 1064539002073 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1064539002074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539002075 active site 1064539002076 phosphorylation site [posttranslational modification] 1064539002077 intermolecular recognition site; other site 1064539002078 dimerization interface [polypeptide binding]; other site 1064539002079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539002080 DNA binding residues [nucleotide binding] 1064539002081 dimerization interface [polypeptide binding]; other site 1064539002082 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539002083 ligand binding site [chemical binding]; other site 1064539002084 flexible hinge region; other site 1064539002085 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1064539002086 non-specific DNA interactions [nucleotide binding]; other site 1064539002087 DNA binding site [nucleotide binding] 1064539002088 sequence specific DNA binding site [nucleotide binding]; other site 1064539002089 putative cAMP binding site [chemical binding]; other site 1064539002090 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1064539002091 thioredoxin 2; Provisional; Region: PRK10996 1064539002092 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1064539002093 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1064539002094 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1064539002095 HSP70 interaction site [polypeptide binding]; other site 1064539002096 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1064539002097 substrate binding site [polypeptide binding]; other site 1064539002098 dimer interface [polypeptide binding]; other site 1064539002099 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1064539002100 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1064539002101 Thioredoxin; Region: Thioredoxin_4; pfam13462 1064539002102 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1064539002103 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064539002104 Ligand Binding Site [chemical binding]; other site 1064539002105 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1064539002106 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539002107 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064539002108 protein binding site [polypeptide binding]; other site 1064539002109 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064539002110 protein binding site [polypeptide binding]; other site 1064539002111 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1064539002112 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1064539002113 PRC-barrel domain; Region: PRC; pfam05239 1064539002114 Protein of unknown function (DUF1269); Region: DUF1269; pfam06897 1064539002115 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 1064539002116 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1064539002117 Clp amino terminal domain; Region: Clp_N; pfam02861 1064539002118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539002119 Walker A motif; other site 1064539002120 ATP binding site [chemical binding]; other site 1064539002121 Walker B motif; other site 1064539002122 arginine finger; other site 1064539002123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539002124 Walker A motif; other site 1064539002125 ATP binding site [chemical binding]; other site 1064539002126 Walker B motif; other site 1064539002127 arginine finger; other site 1064539002128 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1064539002129 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10393315, 10869428, 1459952, 7665466, 8134349, 9144776,9707441; Product type f : factor 1064539002130 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10393315, 10869428, 1459952, 7665466, 8134349, 9144776,9707441; Product type f : factor 1064539002131 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1064539002132 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1064539002133 ring oligomerisation interface [polypeptide binding]; other site 1064539002134 ATP/Mg binding site [chemical binding]; other site 1064539002135 stacking interactions; other site 1064539002136 hinge regions; other site 1064539002137 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1064539002138 oligomerisation interface [polypeptide binding]; other site 1064539002139 mobile loop; other site 1064539002140 roof hairpin; other site 1064539002141 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1064539002142 dimer interface [polypeptide binding]; other site 1064539002143 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1064539002144 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1064539002145 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1064539002146 BON domain; Region: BON; pfam04972 1064539002147 BON domain; Region: BON; pfam04972 1064539002148 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064539002149 Ligand Binding Site [chemical binding]; other site 1064539002150 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064539002151 Ligand Binding Site [chemical binding]; other site 1064539002152 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1064539002153 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 1064539002154 potential frameshift: common BLAST hit: gi|92109700|ref|YP_571986.1| integrase catalytic subunit 1064539002155 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1064539002156 Integrase core domain; Region: rve; pfam00665 1064539002157 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064539002158 DNA binding site [nucleotide binding] 1064539002159 Int/Topo IB signature motif; other site 1064539002160 active site 1064539002161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539002162 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539002163 NAD(P) binding site [chemical binding]; other site 1064539002164 active site 1064539002165 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539002166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539002167 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064539002168 dimerization interface [polypeptide binding]; other site 1064539002169 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 1064539002170 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1064539002171 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1064539002172 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539002173 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1064539002174 Walker A/P-loop; other site 1064539002175 ATP binding site [chemical binding]; other site 1064539002176 Q-loop/lid; other site 1064539002177 ABC transporter signature motif; other site 1064539002178 Walker B; other site 1064539002179 D-loop; other site 1064539002180 H-loop/switch region; other site 1064539002181 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1064539002182 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064539002183 ABC-ATPase subunit interface; other site 1064539002184 dimer interface [polypeptide binding]; other site 1064539002185 putative PBP binding regions; other site 1064539002186 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064539002187 dimer interface [polypeptide binding]; other site 1064539002188 putative PBP binding regions; other site 1064539002189 ABC-ATPase subunit interface; other site 1064539002190 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1064539002191 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1064539002192 siderophore binding site; other site 1064539002193 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1064539002194 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1064539002195 Walker A/P-loop; other site 1064539002196 ATP binding site [chemical binding]; other site 1064539002197 Q-loop/lid; other site 1064539002198 ABC transporter signature motif; other site 1064539002199 Walker B; other site 1064539002200 D-loop; other site 1064539002201 H-loop/switch region; other site 1064539002202 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 1064539002203 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539002204 N-terminal plug; other site 1064539002205 ligand-binding site [chemical binding]; other site 1064539002206 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064539002207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539002208 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1064539002209 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1064539002210 active site 1064539002211 catalytic site [active] 1064539002212 substrate binding site [chemical binding]; other site 1064539002213 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1064539002214 Dimer interface [polypeptide binding]; other site 1064539002215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539002216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539002217 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1064539002218 putative substrate binding pocket [chemical binding]; other site 1064539002219 putative dimerization interface [polypeptide binding]; other site 1064539002220 potential frameshift: common BLAST hit: gi|239820844|ref|YP_002948029.1| major facilitator superfamily MFS_1 1064539002221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539002222 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1064539002223 dimer interface [polypeptide binding]; other site 1064539002224 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064539002225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539002226 DNA-binding site [nucleotide binding]; DNA binding site 1064539002227 FCD domain; Region: FCD; pfam07729 1064539002228 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539002229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539002230 dimer interface [polypeptide binding]; other site 1064539002231 conserved gate region; other site 1064539002232 putative PBP binding loops; other site 1064539002233 ABC-ATPase subunit interface; other site 1064539002234 NMT1/THI5 like; Region: NMT1; pfam09084 1064539002235 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539002236 substrate binding pocket [chemical binding]; other site 1064539002237 membrane-bound complex binding site; other site 1064539002238 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539002239 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539002240 Walker A/P-loop; other site 1064539002241 ATP binding site [chemical binding]; other site 1064539002242 Q-loop/lid; other site 1064539002243 ABC transporter signature motif; other site 1064539002244 Walker B; other site 1064539002245 D-loop; other site 1064539002246 H-loop/switch region; other site 1064539002247 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1064539002248 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1064539002249 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1064539002250 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1064539002251 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539002252 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539002253 putative CheW interface [polypeptide binding]; other site 1064539002254 NAD synthetase; Reviewed; Region: nadE; PRK02628 1064539002255 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1064539002256 multimer interface [polypeptide binding]; other site 1064539002257 active site 1064539002258 catalytic triad [active] 1064539002259 protein interface 1 [polypeptide binding]; other site 1064539002260 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1064539002261 homodimer interface [polypeptide binding]; other site 1064539002262 NAD binding pocket [chemical binding]; other site 1064539002263 ATP binding pocket [chemical binding]; other site 1064539002264 Mg binding site [ion binding]; other site 1064539002265 active-site loop [active] 1064539002266 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1064539002267 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1064539002268 active site 1064539002269 catalytic triad [active] 1064539002270 dimer interface [polypeptide binding]; other site 1064539002271 OpgC protein; Region: OpgC_C; cl17858 1064539002272 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1064539002273 active site 1064539002274 catalytic triad [active] 1064539002275 oxyanion hole [active] 1064539002276 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1064539002277 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064539002278 Walker A/P-loop; other site 1064539002279 ATP binding site [chemical binding]; other site 1064539002280 Q-loop/lid; other site 1064539002281 ABC transporter signature motif; other site 1064539002282 Walker B; other site 1064539002283 D-loop; other site 1064539002284 H-loop/switch region; other site 1064539002285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539002286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539002287 ABC-ATPase subunit interface; other site 1064539002288 putative PBP binding loops; other site 1064539002289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539002290 dimer interface [polypeptide binding]; other site 1064539002291 conserved gate region; other site 1064539002292 putative PBP binding loops; other site 1064539002293 ABC-ATPase subunit interface; other site 1064539002294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539002295 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539002296 substrate binding pocket [chemical binding]; other site 1064539002297 membrane-bound complex binding site; other site 1064539002298 hinge residues; other site 1064539002299 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1064539002300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539002301 DNA-binding site [nucleotide binding]; DNA binding site 1064539002302 FCD domain; Region: FCD; pfam07729 1064539002303 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1064539002304 classical (c) SDRs; Region: SDR_c; cd05233 1064539002305 NAD(P) binding site [chemical binding]; other site 1064539002306 active site 1064539002307 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1064539002308 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1064539002309 NAD binding site [chemical binding]; other site 1064539002310 catalytic Zn binding site [ion binding]; other site 1064539002311 structural Zn binding site [ion binding]; other site 1064539002312 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1064539002313 carbon starvation protein A; Provisional; Region: PRK15015 1064539002314 Carbon starvation protein CstA; Region: CstA; pfam02554 1064539002315 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1064539002316 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1064539002317 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1064539002318 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1064539002319 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1064539002320 Secretin and TonB N terminus short domain; Region: STN; smart00965 1064539002321 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1064539002322 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539002323 N-terminal plug; other site 1064539002324 ligand-binding site [chemical binding]; other site 1064539002325 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064539002326 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064539002327 DNA binding site [nucleotide binding] 1064539002328 domain linker motif; other site 1064539002329 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1064539002330 putative dimerization interface [polypeptide binding]; other site 1064539002331 putative ligand binding site [chemical binding]; other site 1064539002332 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1064539002333 classical (c) SDRs; Region: SDR_c; cd05233 1064539002334 NAD(P) binding site [chemical binding]; other site 1064539002335 active site 1064539002336 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1064539002337 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064539002338 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1064539002339 enoyl-CoA hydratase; Provisional; Region: PRK06688 1064539002340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539002341 substrate binding site [chemical binding]; other site 1064539002342 oxyanion hole (OAH) forming residues; other site 1064539002343 trimer interface [polypeptide binding]; other site 1064539002344 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 1064539002345 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1064539002346 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1064539002347 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1064539002348 dimer interface [polypeptide binding]; other site 1064539002349 NADP binding site [chemical binding]; other site 1064539002350 catalytic residues [active] 1064539002351 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1064539002352 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1064539002353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539002354 dimer interface [polypeptide binding]; other site 1064539002355 conserved gate region; other site 1064539002356 putative PBP binding loops; other site 1064539002357 ABC-ATPase subunit interface; other site 1064539002358 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1064539002359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539002360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539002361 dimer interface [polypeptide binding]; other site 1064539002362 conserved gate region; other site 1064539002363 putative PBP binding loops; other site 1064539002364 ABC-ATPase subunit interface; other site 1064539002365 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1064539002366 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1064539002367 Walker A/P-loop; other site 1064539002368 ATP binding site [chemical binding]; other site 1064539002369 Q-loop/lid; other site 1064539002370 ABC transporter signature motif; other site 1064539002371 Walker B; other site 1064539002372 D-loop; other site 1064539002373 H-loop/switch region; other site 1064539002374 TOBE domain; Region: TOBE_2; pfam08402 1064539002375 Outer membrane efflux protein; Region: OEP; pfam02321 1064539002376 Outer membrane efflux protein; Region: OEP; pfam02321 1064539002377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539002378 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1064539002379 Walker A/P-loop; other site 1064539002380 ATP binding site [chemical binding]; other site 1064539002381 Q-loop/lid; other site 1064539002382 ABC transporter signature motif; other site 1064539002383 Walker B; other site 1064539002384 D-loop; other site 1064539002385 H-loop/switch region; other site 1064539002386 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1064539002387 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539002388 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539002389 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539002390 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1064539002391 ligand binding site [chemical binding]; other site 1064539002392 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1064539002393 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064539002394 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1064539002395 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1064539002396 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539002397 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539002398 substrate binding pocket [chemical binding]; other site 1064539002399 membrane-bound complex binding site; other site 1064539002400 hinge residues; other site 1064539002401 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 1064539002402 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1064539002403 Walker A/P-loop; other site 1064539002404 ATP binding site [chemical binding]; other site 1064539002405 Q-loop/lid; other site 1064539002406 ABC transporter signature motif; other site 1064539002407 Walker B; other site 1064539002408 D-loop; other site 1064539002409 H-loop/switch region; other site 1064539002410 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1064539002411 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1064539002412 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1064539002413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539002414 Walker A/P-loop; other site 1064539002415 ATP binding site [chemical binding]; other site 1064539002416 Q-loop/lid; other site 1064539002417 ABC transporter signature motif; other site 1064539002418 Walker B; other site 1064539002419 D-loop; other site 1064539002420 H-loop/switch region; other site 1064539002421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539002422 NAD(P) binding site [chemical binding]; other site 1064539002423 active site 1064539002424 SET domain; Region: SET; pfam00856 1064539002425 Gram-negative porin; Region: Porin_4; pfam13609 1064539002426 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1064539002427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064539002428 putative metal binding site [ion binding]; other site 1064539002429 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 1064539002430 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1064539002431 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1064539002432 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1064539002433 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1064539002434 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1064539002435 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064539002436 active site 1064539002437 phosphorylation site [posttranslational modification] 1064539002438 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1064539002439 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1064539002440 dimerization interface [polypeptide binding]; other site 1064539002441 NAD binding site [chemical binding]; other site 1064539002442 ligand binding site [chemical binding]; other site 1064539002443 catalytic site [active] 1064539002444 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1064539002445 ATP binding site [chemical binding]; other site 1064539002446 active site 1064539002447 substrate binding site [chemical binding]; other site 1064539002448 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1064539002449 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1064539002450 CheD chemotactic sensory transduction; Region: CheD; cl00810 1064539002451 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539002452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539002453 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1064539002454 putative catalytic site [active] 1064539002455 putative metal binding site [ion binding]; other site 1064539002456 putative phosphate binding site [ion binding]; other site 1064539002457 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1064539002458 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1064539002459 tetramerization interface [polypeptide binding]; other site 1064539002460 active site 1064539002461 CheW-like domain; Region: CheW; pfam01584 1064539002462 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1064539002463 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1064539002464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539002465 TPR motif; other site 1064539002466 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1064539002467 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1064539002468 HAMP domain; Region: HAMP; pfam00672 1064539002469 dimerization interface [polypeptide binding]; other site 1064539002470 potential frameshift: common BLAST hit: gi|374999157|ref|YP_004974655.1| methyl-accepting chemotaxis sensory transducer 1064539002471 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539002472 dimer interface [polypeptide binding]; other site 1064539002473 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1064539002474 putative CheW interface [polypeptide binding]; other site 1064539002475 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15916598; Product type e : enzyme 1064539002476 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15916598; Product type e : enzyme 1064539002477 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1064539002478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539002479 active site 1064539002480 phosphorylation site [posttranslational modification] 1064539002481 intermolecular recognition site; other site 1064539002482 dimerization interface [polypeptide binding]; other site 1064539002483 CheB methylesterase; Region: CheB_methylest; pfam01339 1064539002484 potential frameshift: common BLAST hit: gi|288960045|ref|YP_003450385.1| two-component response regulator 1064539002485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539002486 active site 1064539002487 phosphorylation site [posttranslational modification] 1064539002488 intermolecular recognition site; other site 1064539002489 dimerization interface [polypeptide binding]; other site 1064539002490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539002491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539002492 dimer interface [polypeptide binding]; other site 1064539002493 phosphorylation site [posttranslational modification] 1064539002494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539002495 ATP binding site [chemical binding]; other site 1064539002496 Mg2+ binding site [ion binding]; other site 1064539002497 G-X-G motif; other site 1064539002498 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539002499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539002500 active site 1064539002501 phosphorylation site [posttranslational modification] 1064539002502 intermolecular recognition site; other site 1064539002503 dimerization interface [polypeptide binding]; other site 1064539002504 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1064539002505 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1064539002506 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1064539002507 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1064539002508 4Fe-4S binding domain; Region: Fer4; cl02805 1064539002509 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1064539002510 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1064539002511 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1064539002512 [4Fe-4S] binding site [ion binding]; other site 1064539002513 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064539002514 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1064539002515 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1064539002516 molybdopterin cofactor binding site; other site 1064539002517 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1064539002518 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1064539002519 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1064539002520 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539002521 dimerization interface [polypeptide binding]; other site 1064539002522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539002523 dimer interface [polypeptide binding]; other site 1064539002524 phosphorylation site [posttranslational modification] 1064539002525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539002526 ATP binding site [chemical binding]; other site 1064539002527 Mg2+ binding site [ion binding]; other site 1064539002528 G-X-G motif; other site 1064539002529 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1064539002530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539002531 active site 1064539002532 phosphorylation site [posttranslational modification] 1064539002533 intermolecular recognition site; other site 1064539002534 dimerization interface [polypeptide binding]; other site 1064539002535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539002536 Walker A motif; other site 1064539002537 ATP binding site [chemical binding]; other site 1064539002538 Walker B motif; other site 1064539002539 arginine finger; other site 1064539002540 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539002541 aldolase II superfamily protein; Provisional; Region: PRK07044 1064539002542 intersubunit interface [polypeptide binding]; other site 1064539002543 active site 1064539002544 Zn2+ binding site [ion binding]; other site 1064539002545 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 1064539002546 active site 1 [active] 1064539002547 dimer interface [polypeptide binding]; other site 1064539002548 hexamer interface [polypeptide binding]; other site 1064539002549 active site 2 [active] 1064539002550 exonuclease subunit SbcD; Provisional; Region: PRK10966 1064539002551 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1064539002552 active site 1064539002553 metal binding site [ion binding]; metal-binding site 1064539002554 DNA binding site [nucleotide binding] 1064539002555 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1064539002556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539002557 Walker A/P-loop; other site 1064539002558 ATP binding site [chemical binding]; other site 1064539002559 Q-loop/lid; other site 1064539002560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539002561 ABC transporter signature motif; other site 1064539002562 Walker B; other site 1064539002563 D-loop; other site 1064539002564 H-loop/switch region; other site 1064539002565 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539002566 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 1064539002567 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1064539002568 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539002569 P-loop; other site 1064539002570 Magnesium ion binding site [ion binding]; other site 1064539002571 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539002572 Magnesium ion binding site [ion binding]; other site 1064539002573 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539002574 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1064539002575 ParB-like nuclease domain; Region: ParB; smart00470 1064539002576 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1064539002577 active site 1064539002578 SUMO-1 interface [polypeptide binding]; other site 1064539002579 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1064539002580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539002581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539002582 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1064539002583 putative effector binding pocket; other site 1064539002584 putative dimerization interface [polypeptide binding]; other site 1064539002585 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1064539002586 homotrimer interaction site [polypeptide binding]; other site 1064539002587 putative active site [active] 1064539002588 ANTAR domain; Region: ANTAR; pfam03861 1064539002589 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539002590 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539002591 Walker A/P-loop; other site 1064539002592 ATP binding site [chemical binding]; other site 1064539002593 Q-loop/lid; other site 1064539002594 ABC transporter signature motif; other site 1064539002595 Walker B; other site 1064539002596 D-loop; other site 1064539002597 H-loop/switch region; other site 1064539002598 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539002599 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1064539002600 Walker A/P-loop; other site 1064539002601 ATP binding site [chemical binding]; other site 1064539002602 Q-loop/lid; other site 1064539002603 ABC transporter signature motif; other site 1064539002604 Walker B; other site 1064539002605 D-loop; other site 1064539002606 H-loop/switch region; other site 1064539002607 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539002608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539002609 dimer interface [polypeptide binding]; other site 1064539002610 conserved gate region; other site 1064539002611 putative PBP binding loops; other site 1064539002612 ABC-ATPase subunit interface; other site 1064539002613 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1064539002614 NMT1-like family; Region: NMT1_2; pfam13379 1064539002615 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1064539002616 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539002617 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1064539002618 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1064539002619 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1064539002620 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1064539002621 [2Fe-2S] cluster binding site [ion binding]; other site 1064539002622 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1064539002623 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1064539002624 [4Fe-4S] binding site [ion binding]; other site 1064539002625 molybdopterin cofactor binding site; other site 1064539002626 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1064539002627 molybdopterin cofactor binding site; other site 1064539002628 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1064539002629 active site 1064539002630 SAM binding site [chemical binding]; other site 1064539002631 homodimer interface [polypeptide binding]; other site 1064539002632 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1064539002633 NlpC/P60 family; Region: NLPC_P60; cl17555 1064539002634 potential frameshift: common BLAST hit: gi|288962830|ref|YP_003453124.1| radical SAM 1064539002635 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1064539002636 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1064539002637 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1064539002638 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1064539002639 Predicted integral membrane protein [Function unknown]; Region: COG5616 1064539002640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539002641 binding surface 1064539002642 TPR motif; other site 1064539002643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1064539002644 Peptidase M15; Region: Peptidase_M15_3; cl01194 1064539002645 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1064539002646 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1064539002647 GIY-YIG motif/motif A; other site 1064539002648 active site 1064539002649 catalytic site [active] 1064539002650 putative DNA binding site [nucleotide binding]; other site 1064539002651 metal binding site [ion binding]; metal-binding site 1064539002652 UvrB/uvrC motif; Region: UVR; pfam02151 1064539002653 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1064539002654 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 1064539002655 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 1064539002656 transcriptional regulator; Provisional; Region: PRK10632 1064539002657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539002658 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1064539002659 putative effector binding pocket; other site 1064539002660 dimerization interface [polypeptide binding]; other site 1064539002661 Predicted membrane protein [Function unknown]; Region: COG3748 1064539002662 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1064539002663 Cytochrome c; Region: Cytochrom_C; pfam00034 1064539002664 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1064539002665 active site 1064539002666 homotetramer interface [polypeptide binding]; other site 1064539002667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1064539002668 potential frameshift: common BLAST hit: gi|27381258|ref|NP_772787.1| allantoate amidohydrolase 1064539002669 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1064539002670 metal binding site [ion binding]; metal-binding site 1064539002671 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1064539002672 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 1064539002673 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 1064539002674 putative metal binding site [ion binding]; other site 1064539002675 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1064539002676 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1064539002677 active site 1064539002678 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1064539002679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1064539002680 UDP-galactopyranose mutase; Region: GLF; pfam03275 1064539002681 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 4319723; Product type e : enzyme 1064539002682 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 4319723; Product type e : enzyme 1064539002683 L-aspartate oxidase; Provisional; Region: PRK06175 1064539002684 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1064539002685 L-aspartate oxidase; Provisional; Region: PRK07804 1064539002686 quinolinate synthetase; Provisional; Region: PRK09375 1064539002687 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 1064539002688 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 1064539002689 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 1064539002690 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1064539002691 [4Fe-4S] binding site [ion binding]; other site 1064539002692 molybdopterin cofactor binding site; other site 1064539002693 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064539002694 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1064539002695 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1064539002696 molybdopterin cofactor binding site; other site 1064539002697 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1064539002698 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1064539002699 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1064539002700 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013 1064539002701 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like6; cd08011 1064539002702 metal binding site [ion binding]; metal-binding site 1064539002703 putative dimer interface [polypeptide binding]; other site 1064539002704 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 1064539002705 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1064539002706 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 1064539002707 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 1064539002708 putative catalytic cysteine [active] 1064539002709 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539002710 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539002711 Walker A/P-loop; other site 1064539002712 ATP binding site [chemical binding]; other site 1064539002713 Q-loop/lid; other site 1064539002714 ABC transporter signature motif; other site 1064539002715 Walker B; other site 1064539002716 D-loop; other site 1064539002717 H-loop/switch region; other site 1064539002718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539002719 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539002720 NMT1/THI5 like; Region: NMT1; pfam09084 1064539002721 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1064539002722 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 1064539002723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539002724 NAD(P) binding site [chemical binding]; other site 1064539002725 active site 1064539002726 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1064539002727 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539002728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539002729 active site 1064539002730 phosphorylation site [posttranslational modification] 1064539002731 intermolecular recognition site; other site 1064539002732 dimerization interface [polypeptide binding]; other site 1064539002733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539002734 DNA binding site [nucleotide binding] 1064539002735 potential frameshift: common BLAST hit: gi|288960014|ref|YP_003450354.1| two-component sensor histidine kinase 1064539002736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539002737 ATP binding site [chemical binding]; other site 1064539002738 Mg2+ binding site [ion binding]; other site 1064539002739 G-X-G motif; other site 1064539002740 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1064539002741 Chromate transporter; Region: Chromate_transp; pfam02417 1064539002742 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1064539002743 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1064539002744 C-terminal domain interface [polypeptide binding]; other site 1064539002745 GSH binding site (G-site) [chemical binding]; other site 1064539002746 dimer interface [polypeptide binding]; other site 1064539002747 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1064539002748 dimer interface [polypeptide binding]; other site 1064539002749 N-terminal domain interface [polypeptide binding]; other site 1064539002750 substrate binding pocket (H-site) [chemical binding]; other site 1064539002751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539002752 Coenzyme A binding pocket [chemical binding]; other site 1064539002753 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7902833; Product type e : enzyme 1064539002754 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7902833; Product type e : enzyme 1064539002755 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2643092, 7902833; Product type e : enzyme 1064539002756 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2643092, 7902833; Product type e : enzyme 1064539002757 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1064539002758 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1064539002759 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1064539002760 putative NAD(P) binding site [chemical binding]; other site 1064539002761 active site 1064539002762 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1064539002763 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1064539002764 catalytic site [active] 1064539002765 putative active site [active] 1064539002766 putative substrate binding site [chemical binding]; other site 1064539002767 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1064539002768 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1064539002769 putative active site [active] 1064539002770 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1064539002771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 1064539002772 OstA-like protein; Region: OstA; cl00844 1064539002773 OstA-like protein; Region: OstA; cl00844 1064539002774 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1064539002775 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1064539002776 Walker A/P-loop; other site 1064539002777 ATP binding site [chemical binding]; other site 1064539002778 Q-loop/lid; other site 1064539002779 ABC transporter signature motif; other site 1064539002780 Walker B; other site 1064539002781 D-loop; other site 1064539002782 H-loop/switch region; other site 1064539002783 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1064539002784 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1064539002785 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1064539002786 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1064539002787 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1064539002788 30S subunit binding site; other site 1064539002789 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064539002790 active site 1064539002791 phosphorylation site [posttranslational modification] 1064539002792 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1064539002793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539002794 S-adenosylmethionine binding site [chemical binding]; other site 1064539002795 aspartate kinase; Reviewed; Region: PRK06635 1064539002796 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1064539002797 putative nucleotide binding site [chemical binding]; other site 1064539002798 putative catalytic residues [active] 1064539002799 putative Mg ion binding site [ion binding]; other site 1064539002800 putative aspartate binding site [chemical binding]; other site 1064539002801 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1064539002802 putative allosteric regulatory site; other site 1064539002803 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1064539002804 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1064539002805 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1064539002806 FMN binding site [chemical binding]; other site 1064539002807 substrate binding site [chemical binding]; other site 1064539002808 putative catalytic residue [active] 1064539002809 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1064539002810 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1064539002811 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1064539002812 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1064539002813 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1064539002814 Evidence 4 : Homologs of previously reported genes of unknown function 1064539002815 Evidence 4 : Homologs of previously reported genes of unknown function 1064539002816 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1064539002817 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1064539002818 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1064539002819 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1064539002820 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1064539002821 NAD(P) binding pocket [chemical binding]; other site 1064539002822 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1064539002823 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1064539002824 RF-1 domain; Region: RF-1; pfam00472 1064539002825 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1064539002826 putative active site [active] 1064539002827 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1064539002828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539002829 S-adenosylmethionine binding site [chemical binding]; other site 1064539002830 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 1064539002831 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1064539002832 MOSC domain; Region: MOSC; pfam03473 1064539002833 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1064539002834 nudix motif; other site 1064539002835 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1064539002836 Clp amino terminal domain; Region: Clp_N; pfam02861 1064539002837 Clp amino terminal domain; Region: Clp_N; pfam02861 1064539002838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539002839 Walker A motif; other site 1064539002840 ATP binding site [chemical binding]; other site 1064539002841 Walker B motif; other site 1064539002842 arginine finger; other site 1064539002843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539002844 Walker A motif; other site 1064539002845 ATP binding site [chemical binding]; other site 1064539002846 Walker B motif; other site 1064539002847 arginine finger; other site 1064539002848 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1064539002849 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1064539002850 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1064539002851 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1064539002852 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1064539002853 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1064539002854 HAMP domain; Region: HAMP; pfam00672 1064539002855 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539002856 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539002857 dimer interface [polypeptide binding]; other site 1064539002858 putative CheW interface [polypeptide binding]; other site 1064539002859 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539002860 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1064539002861 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 1064539002862 Walker A/P-loop; other site 1064539002863 ATP binding site [chemical binding]; other site 1064539002864 Q-loop/lid; other site 1064539002865 ABC transporter signature motif; other site 1064539002866 Walker B; other site 1064539002867 D-loop; other site 1064539002868 H-loop/switch region; other site 1064539002869 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 1064539002870 heme binding pocket [chemical binding]; other site 1064539002871 heme ligand [chemical binding]; other site 1064539002872 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1064539002873 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1064539002874 Walker A; other site 1064539002875 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1064539002876 RecX family; Region: RecX; cl00936 1064539002877 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1064539002878 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064539002879 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 1064539002880 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064539002881 inhibitor-cofactor binding pocket; inhibition site 1064539002882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539002883 catalytic residue [active] 1064539002884 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1064539002885 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1064539002886 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1064539002887 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1064539002888 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1064539002889 dimerization interface [polypeptide binding]; other site 1064539002890 domain crossover interface; other site 1064539002891 redox-dependent activation switch; other site 1064539002892 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 1064539002893 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1064539002894 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1064539002895 homotetramer interface [polypeptide binding]; other site 1064539002896 ligand binding site [chemical binding]; other site 1064539002897 catalytic site [active] 1064539002898 NAD binding site [chemical binding]; other site 1064539002899 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1064539002900 active site 1064539002901 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1064539002902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539002903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539002904 hypothetical protein; Validated; Region: PRK09071 1064539002905 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1064539002906 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1064539002907 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539002908 N-terminal plug; other site 1064539002909 ligand-binding site [chemical binding]; other site 1064539002910 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1064539002911 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064539002912 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1064539002913 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1064539002914 active site 1064539002915 substrate binding site [chemical binding]; other site 1064539002916 FMN binding site [chemical binding]; other site 1064539002917 putative catalytic residues [active] 1064539002918 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1064539002919 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1064539002920 Walker A/P-loop; other site 1064539002921 ATP binding site [chemical binding]; other site 1064539002922 Q-loop/lid; other site 1064539002923 ABC transporter signature motif; other site 1064539002924 Walker B; other site 1064539002925 D-loop; other site 1064539002926 H-loop/switch region; other site 1064539002927 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1064539002928 ABC-ATPase subunit interface; other site 1064539002929 dimer interface [polypeptide binding]; other site 1064539002930 putative PBP binding regions; other site 1064539002931 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1064539002932 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064539002933 ABC-ATPase subunit interface; other site 1064539002934 dimer interface [polypeptide binding]; other site 1064539002935 putative PBP binding regions; other site 1064539002936 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1064539002937 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1064539002938 putative ligand binding residues [chemical binding]; other site 1064539002939 Predicted transcriptional regulators [Transcription]; Region: COG1695 1064539002940 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1064539002941 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 1064539002942 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1064539002943 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1064539002944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539002945 dimer interface [polypeptide binding]; other site 1064539002946 phosphorylation site [posttranslational modification] 1064539002947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539002948 ATP binding site [chemical binding]; other site 1064539002949 Mg2+ binding site [ion binding]; other site 1064539002950 G-X-G motif; other site 1064539002951 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539002952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539002953 active site 1064539002954 phosphorylation site [posttranslational modification] 1064539002955 intermolecular recognition site; other site 1064539002956 dimerization interface [polypeptide binding]; other site 1064539002957 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539002958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539002959 active site 1064539002960 phosphorylation site [posttranslational modification] 1064539002961 intermolecular recognition site; other site 1064539002962 dimerization interface [polypeptide binding]; other site 1064539002963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539002964 dimer interface [polypeptide binding]; other site 1064539002965 phosphorylation site [posttranslational modification] 1064539002966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539002967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539002968 ATP binding site [chemical binding]; other site 1064539002969 Mg2+ binding site [ion binding]; other site 1064539002970 G-X-G motif; other site 1064539002971 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1064539002972 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1064539002973 Walker A/P-loop; other site 1064539002974 ATP binding site [chemical binding]; other site 1064539002975 Q-loop/lid; other site 1064539002976 ABC transporter signature motif; other site 1064539002977 Walker B; other site 1064539002978 D-loop; other site 1064539002979 H-loop/switch region; other site 1064539002980 FecCD transport family; Region: FecCD; pfam01032 1064539002981 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1064539002982 ABC-ATPase subunit interface; other site 1064539002983 dimer interface [polypeptide binding]; other site 1064539002984 putative PBP binding regions; other site 1064539002985 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1064539002986 intersubunit interface [polypeptide binding]; other site 1064539002987 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1064539002988 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539002989 N-terminal plug; other site 1064539002990 ligand-binding site [chemical binding]; other site 1064539002991 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1064539002992 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1064539002993 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 1064539002994 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1064539002995 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1064539002996 tetramer interface [polypeptide binding]; other site 1064539002997 active site 1064539002998 Mg2+/Mn2+ binding site [ion binding]; other site 1064539002999 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1064539003000 dimerization interface [polypeptide binding]; other site 1064539003001 metal binding site [ion binding]; metal-binding site 1064539003002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539003003 NAD(P) binding site [chemical binding]; other site 1064539003004 active site 1064539003005 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539003006 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539003007 Phytochelatin synthase; Region: Phytochelatin; pfam05023 1064539003008 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1064539003009 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1064539003010 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1064539003011 Na binding site [ion binding]; other site 1064539003012 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1064539003013 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1064539003014 OsmC-like protein; Region: OsmC; pfam02566 1064539003015 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1064539003016 Rrf2 family protein; Region: rrf2_super; TIGR00738 1064539003017 Transcriptional regulator; Region: Rrf2; pfam02082 1064539003018 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1064539003019 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1064539003020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539003021 dimer interface [polypeptide binding]; other site 1064539003022 conserved gate region; other site 1064539003023 putative PBP binding loops; other site 1064539003024 ABC-ATPase subunit interface; other site 1064539003025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539003026 dimer interface [polypeptide binding]; other site 1064539003027 conserved gate region; other site 1064539003028 putative PBP binding loops; other site 1064539003029 ABC-ATPase subunit interface; other site 1064539003030 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1064539003031 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1064539003032 Walker A/P-loop; other site 1064539003033 ATP binding site [chemical binding]; other site 1064539003034 Q-loop/lid; other site 1064539003035 ABC transporter signature motif; other site 1064539003036 Walker B; other site 1064539003037 D-loop; other site 1064539003038 H-loop/switch region; other site 1064539003039 TOBE domain; Region: TOBE_2; pfam08402 1064539003040 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1064539003041 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1064539003042 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1064539003043 TrkA-N domain; Region: TrkA_N; pfam02254 1064539003044 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539003045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539003046 active site 1064539003047 phosphorylation site [posttranslational modification] 1064539003048 intermolecular recognition site; other site 1064539003049 dimerization interface [polypeptide binding]; other site 1064539003050 MarR family; Region: MarR_2; pfam12802 1064539003051 potential protein location (conserved protein of unknown function [Azospirillum brasilense Sp245]) that overlaps RNA (ribosomal RNA 16s ribosomal RNA) 1064539003052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1064539003053 NAD synthetase; Reviewed; Region: nadE; PRK00876 1064539003054 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1064539003055 Ligand Binding Site [chemical binding]; other site 1064539003056 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1064539003057 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1064539003058 active site 1064539003059 dimer interface [polypeptide binding]; other site 1064539003060 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1064539003061 Ligand Binding Site [chemical binding]; other site 1064539003062 Molecular Tunnel; other site 1064539003063 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1064539003064 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539003065 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539003066 acyl-activating enzyme (AAE) consensus motif; other site 1064539003067 AMP binding site [chemical binding]; other site 1064539003068 active site 1064539003069 CoA binding site [chemical binding]; other site 1064539003070 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1064539003071 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1064539003072 putative active site [active] 1064539003073 putative metal binding site [ion binding]; other site 1064539003074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539003075 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1064539003076 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1064539003077 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539003078 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1064539003079 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1064539003080 active site 1064539003081 O-Antigen ligase; Region: Wzy_C; pfam04932 1064539003082 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1064539003083 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1064539003084 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1064539003085 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1064539003086 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1064539003087 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1064539003088 Calx-beta domain; Region: Calx-beta; pfam03160 1064539003089 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1064539003090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539003091 S-adenosylmethionine binding site [chemical binding]; other site 1064539003092 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1064539003093 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 1064539003094 Chain length determinant protein; Region: Wzz; pfam02706 1064539003095 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1064539003096 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1064539003097 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1064539003098 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539003099 nucleotide binding region [chemical binding]; other site 1064539003100 ATP-binding site [chemical binding]; other site 1064539003101 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 1064539003102 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 1064539003103 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064539003104 catalytic core [active] 1064539003105 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064539003106 Helix-turn-helix domain; Region: HTH_36; pfam13730 1064539003107 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1064539003108 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1064539003109 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1064539003110 active site 1064539003111 catalytic site [active] 1064539003112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539003113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539003114 dimer interface [polypeptide binding]; other site 1064539003115 phosphorylation site [posttranslational modification] 1064539003116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539003117 ATP binding site [chemical binding]; other site 1064539003118 Mg2+ binding site [ion binding]; other site 1064539003119 G-X-G motif; other site 1064539003120 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539003121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539003122 active site 1064539003123 phosphorylation site [posttranslational modification] 1064539003124 intermolecular recognition site; other site 1064539003125 dimerization interface [polypeptide binding]; other site 1064539003126 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1064539003127 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539003128 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539003129 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539003130 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539003131 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539003132 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539003133 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 1064539003134 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1064539003135 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1064539003136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539003137 dimer interface [polypeptide binding]; other site 1064539003138 conserved gate region; other site 1064539003139 ABC-ATPase subunit interface; other site 1064539003140 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1064539003141 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1064539003142 Walker A/P-loop; other site 1064539003143 ATP binding site [chemical binding]; other site 1064539003144 Q-loop/lid; other site 1064539003145 ABC transporter signature motif; other site 1064539003146 Walker B; other site 1064539003147 D-loop; other site 1064539003148 H-loop/switch region; other site 1064539003149 NIL domain; Region: NIL; pfam09383 1064539003150 acyl-CoA synthetase; Validated; Region: PRK08162 1064539003151 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1064539003152 acyl-activating enzyme (AAE) consensus motif; other site 1064539003153 putative active site [active] 1064539003154 AMP binding site [chemical binding]; other site 1064539003155 putative CoA binding site [chemical binding]; other site 1064539003156 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1064539003157 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1064539003158 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1064539003159 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1064539003160 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11842181, 2194167, 3018428; Product type e : enzyme 1064539003161 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11842181, 2194167, 3018428; Product type e : enzyme 1064539003162 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1064539003163 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1064539003164 active site 1064539003165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539003166 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539003167 dimerization interface [polypeptide binding]; other site 1064539003168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539003169 dimer interface [polypeptide binding]; other site 1064539003170 phosphorylation site [posttranslational modification] 1064539003171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539003172 ATP binding site [chemical binding]; other site 1064539003173 Mg2+ binding site [ion binding]; other site 1064539003174 G-X-G motif; other site 1064539003175 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539003176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539003177 active site 1064539003178 phosphorylation site [posttranslational modification] 1064539003179 intermolecular recognition site; other site 1064539003180 dimerization interface [polypeptide binding]; other site 1064539003181 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539003182 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539003183 catalytic residue [active] 1064539003184 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1064539003185 rRNA binding site [nucleotide binding]; other site 1064539003186 predicted 30S ribosome binding site; other site 1064539003187 Maf-like protein; Region: Maf; pfam02545 1064539003188 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1064539003189 active site 1064539003190 dimer interface [polypeptide binding]; other site 1064539003191 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1064539003192 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1064539003193 homodimer interface [polypeptide binding]; other site 1064539003194 oligonucleotide binding site [chemical binding]; other site 1064539003195 Domain of unknown function (DUF329); Region: DUF329; cl01144 1064539003196 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 1064539003197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539003198 TPR motif; other site 1064539003199 binding surface 1064539003200 TPR repeat; Region: TPR_11; pfam13414 1064539003201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539003202 binding surface 1064539003203 TPR motif; other site 1064539003204 TPR repeat; Region: TPR_11; pfam13414 1064539003205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539003206 binding surface 1064539003207 TPR motif; other site 1064539003208 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1064539003209 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1064539003210 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539003211 active site 1064539003212 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1064539003213 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539003214 P-loop; other site 1064539003215 Magnesium ion binding site [ion binding]; other site 1064539003216 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539003217 Magnesium ion binding site [ion binding]; other site 1064539003218 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1064539003219 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1064539003220 AsnC family; Region: AsnC_trans_reg; pfam01037 1064539003221 agmatinase; Region: agmatinase; TIGR01230 1064539003222 Arginase family; Region: Arginase; cd09989 1064539003223 active site 1064539003224 Mn binding site [ion binding]; other site 1064539003225 oligomer interface [polypeptide binding]; other site 1064539003226 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 1064539003227 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064539003228 inhibitor-cofactor binding pocket; inhibition site 1064539003229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539003230 catalytic residue [active] 1064539003231 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1064539003232 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1064539003233 active site 1064539003234 Zn binding site [ion binding]; other site 1064539003235 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539003236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539003237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539003238 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 1064539003239 putative hydrophobic ligand binding site [chemical binding]; other site 1064539003240 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1064539003241 dimer interface [polypeptide binding]; other site 1064539003242 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 1064539003243 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 1064539003244 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064539003245 inhibitor-cofactor binding pocket; inhibition site 1064539003246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539003247 catalytic residue [active] 1064539003248 succinic semialdehyde dehydrogenase; Region: PLN02278 1064539003249 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1064539003250 tetramerization interface [polypeptide binding]; other site 1064539003251 NAD(P) binding site [chemical binding]; other site 1064539003252 catalytic residues [active] 1064539003253 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1064539003254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539003255 non-specific DNA binding site [nucleotide binding]; other site 1064539003256 salt bridge; other site 1064539003257 sequence-specific DNA binding site [nucleotide binding]; other site 1064539003258 Cupin domain; Region: Cupin_2; pfam07883 1064539003259 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064539003260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539003261 dimer interface [polypeptide binding]; other site 1064539003262 conserved gate region; other site 1064539003263 putative PBP binding loops; other site 1064539003264 ABC-ATPase subunit interface; other site 1064539003265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539003266 dimer interface [polypeptide binding]; other site 1064539003267 conserved gate region; other site 1064539003268 putative PBP binding loops; other site 1064539003269 ABC-ATPase subunit interface; other site 1064539003270 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1064539003271 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539003272 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1064539003273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539003274 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1064539003275 dimerization interface [polypeptide binding]; other site 1064539003276 substrate binding pocket [chemical binding]; other site 1064539003277 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1064539003278 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539003279 FAD binding site [chemical binding]; other site 1064539003280 substrate binding pocket [chemical binding]; other site 1064539003281 catalytic base [active] 1064539003282 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1064539003283 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064539003284 EamA-like transporter family; Region: EamA; pfam00892 1064539003285 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539003286 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1064539003287 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1064539003288 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1064539003289 transmembrane helices; other site 1064539003290 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1064539003291 TrkA-C domain; Region: TrkA_C; pfam02080 1064539003292 TrkA-C domain; Region: TrkA_C; pfam02080 1064539003293 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1064539003294 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064539003295 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064539003296 active site 1064539003297 catalytic tetrad [active] 1064539003298 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539003299 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539003300 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539003301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539003302 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064539003303 dimerization interface [polypeptide binding]; other site 1064539003304 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1064539003305 MarR family; Region: MarR_2; pfam12802 1064539003306 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1064539003307 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539003308 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539003309 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1064539003310 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1064539003311 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1064539003312 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1064539003313 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1064539003314 active site 1064539003315 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1064539003316 TPR repeat; Region: TPR_11; pfam13414 1064539003317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539003318 binding surface 1064539003319 TPR motif; other site 1064539003320 TPR repeat; Region: TPR_11; pfam13414 1064539003321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539003322 binding surface 1064539003323 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 1064539003324 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1064539003325 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 1064539003326 active site 1064539003327 acyl-activating enzyme (AAE) consensus motif; other site 1064539003328 putative CoA binding site [chemical binding]; other site 1064539003329 AMP binding site [chemical binding]; other site 1064539003330 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539003331 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539003332 Walker A/P-loop; other site 1064539003333 ATP binding site [chemical binding]; other site 1064539003334 Q-loop/lid; other site 1064539003335 ABC transporter signature motif; other site 1064539003336 Walker B; other site 1064539003337 D-loop; other site 1064539003338 H-loop/switch region; other site 1064539003339 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1064539003340 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1064539003341 DNA binding residues [nucleotide binding] 1064539003342 putative dimer interface [polypeptide binding]; other site 1064539003343 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1064539003344 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1064539003345 Predicted membrane protein [Function unknown]; Region: COG2860 1064539003346 UPF0126 domain; Region: UPF0126; pfam03458 1064539003347 UPF0126 domain; Region: UPF0126; pfam03458 1064539003348 Pirin-related protein [General function prediction only]; Region: COG1741 1064539003349 Pirin; Region: Pirin; pfam02678 1064539003350 TIGR02588 family protein; Region: TIGR02588 1064539003351 Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622 1064539003352 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11936079; Product type e : enzyme 1064539003353 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11936079; Product type e : enzyme 1064539003354 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11936079; Product type e : enzyme 1064539003355 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1064539003356 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1064539003357 DNA binding residues [nucleotide binding] 1064539003358 dimer interface [polypeptide binding]; other site 1064539003359 copper binding site [ion binding]; other site 1064539003360 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 1064539003361 Zn binding site [ion binding]; other site 1064539003362 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1064539003363 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1064539003364 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1064539003365 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1064539003366 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1064539003367 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064539003368 ABC transporter; Region: ABC_tran_2; pfam12848 1064539003369 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064539003370 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1064539003371 Cupin domain; Region: Cupin_2; pfam07883 1064539003372 potential frameshift: common BLAST hit: gi|288959948|ref|YP_003450288.1| transcriptional regulator 1064539003373 Helix-turn-helix domain; Region: HTH_18; pfam12833 1064539003374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539003375 Homeodomain-like domain; Region: HTH_23; pfam13384 1064539003376 Winged helix-turn helix; Region: HTH_29; pfam13551 1064539003377 Homeodomain-like domain; Region: HTH_32; pfam13565 1064539003378 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1064539003379 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1064539003380 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1064539003381 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1064539003382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539003383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539003384 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1064539003385 putative effector binding pocket; other site 1064539003386 dimerization interface [polypeptide binding]; other site 1064539003387 benzoate transporter; Region: benE; TIGR00843 1064539003388 Benzoate membrane transport protein; Region: BenE; pfam03594 1064539003389 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1064539003390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539003391 DNA-binding site [nucleotide binding]; DNA binding site 1064539003392 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539003393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539003394 homodimer interface [polypeptide binding]; other site 1064539003395 catalytic residue [active] 1064539003396 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1064539003397 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1064539003398 catalytic triad [active] 1064539003399 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1064539003400 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1064539003401 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1064539003402 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1064539003403 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1064539003404 active site 1064539003405 dimer interface [polypeptide binding]; other site 1064539003406 effector binding site; other site 1064539003407 TSCPD domain; Region: TSCPD; pfam12637 1064539003408 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1064539003409 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1064539003410 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1064539003411 putative acyl-acceptor binding pocket; other site 1064539003412 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1064539003413 putative active site [active] 1064539003414 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1064539003415 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1064539003416 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1064539003417 Walker A/P-loop; other site 1064539003418 ATP binding site [chemical binding]; other site 1064539003419 Q-loop/lid; other site 1064539003420 ABC transporter signature motif; other site 1064539003421 Walker B; other site 1064539003422 D-loop; other site 1064539003423 H-loop/switch region; other site 1064539003424 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 1064539003425 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1064539003426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539003427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539003428 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1064539003429 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1064539003430 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539003431 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539003432 potential frameshift: common BLAST hit: gi|374998559|ref|YP_004974058.1| multidrug resistance efflux pump (EmrB-like) 1064539003433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539003434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1064539003435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539003436 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1064539003437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539003438 PAS fold; Region: PAS_3; pfam08447 1064539003439 putative active site [active] 1064539003440 heme pocket [chemical binding]; other site 1064539003441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539003442 PAS fold; Region: PAS_3; pfam08447 1064539003443 putative active site [active] 1064539003444 heme pocket [chemical binding]; other site 1064539003445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539003446 PAS fold; Region: PAS_3; pfam08447 1064539003447 putative active site [active] 1064539003448 heme pocket [chemical binding]; other site 1064539003449 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539003450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539003451 metal binding site [ion binding]; metal-binding site 1064539003452 active site 1064539003453 I-site; other site 1064539003454 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539003455 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1064539003456 Recombination protein O N terminal; Region: RecO_N; pfam11967 1064539003457 Recombination protein O C terminal; Region: RecO_C; pfam02565 1064539003458 potential frameshift: common BLAST hit: gi|288958669|ref|YP_003449010.1| topoisomerase IV subunit A 1064539003459 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1064539003460 CAP-like domain; other site 1064539003461 active site 1064539003462 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1064539003463 primary dimer interface [polypeptide binding]; other site 1064539003464 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1064539003465 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1064539003466 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1064539003467 DctM-like transporters; Region: DctM; pfam06808 1064539003468 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 1064539003469 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1064539003470 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1064539003471 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1064539003472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1064539003473 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1064539003474 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1064539003475 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 1064539003476 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1064539003477 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064539003478 ligand binding site [chemical binding]; other site 1064539003479 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1064539003480 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1064539003481 active site 1064539003482 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539003483 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539003484 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539003485 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1064539003486 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1064539003487 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1064539003488 active site 1064539003489 Cytochrome c; Region: Cytochrom_C; cl11414 1064539003490 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 1064539003491 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 1064539003492 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064539003493 putative binding surface; other site 1064539003494 active site 1064539003495 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1064539003496 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1064539003497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539003498 ATP binding site [chemical binding]; other site 1064539003499 Mg2+ binding site [ion binding]; other site 1064539003500 G-X-G motif; other site 1064539003501 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1064539003502 CheW-like domain; Region: CheW; pfam01584 1064539003503 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539003504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539003505 active site 1064539003506 phosphorylation site [posttranslational modification] 1064539003507 intermolecular recognition site; other site 1064539003508 dimerization interface [polypeptide binding]; other site 1064539003509 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1064539003510 putative CheA interaction surface; other site 1064539003511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539003512 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539003513 active site 1064539003514 phosphorylation site [posttranslational modification] 1064539003515 intermolecular recognition site; other site 1064539003516 dimerization interface [polypeptide binding]; other site 1064539003517 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1064539003518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539003519 active site 1064539003520 phosphorylation site [posttranslational modification] 1064539003521 intermolecular recognition site; other site 1064539003522 dimerization interface [polypeptide binding]; other site 1064539003523 CheB methylesterase; Region: CheB_methylest; pfam01339 1064539003524 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1064539003525 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1064539003526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539003527 S-adenosylmethionine binding site [chemical binding]; other site 1064539003528 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064539003529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539003530 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1064539003531 dimerization interface [polypeptide binding]; other site 1064539003532 substrate binding pocket [chemical binding]; other site 1064539003533 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1064539003534 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539003535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539003536 active site 1064539003537 phosphorylation site [posttranslational modification] 1064539003538 intermolecular recognition site; other site 1064539003539 dimerization interface [polypeptide binding]; other site 1064539003540 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539003541 DNA binding site [nucleotide binding] 1064539003542 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 1064539003543 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1064539003544 Walker A motif/ATP binding site; other site 1064539003545 Walker B motif; other site 1064539003546 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 1064539003547 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539003548 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539003549 metal binding site [ion binding]; metal-binding site 1064539003550 active site 1064539003551 I-site; other site 1064539003552 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1064539003553 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1064539003554 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1064539003555 P-loop; other site 1064539003556 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1064539003557 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539003558 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1064539003559 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1064539003560 FHIPEP family; Region: FHIPEP; pfam00771 1064539003561 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1064539003562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539003563 Walker A motif; other site 1064539003564 ATP binding site [chemical binding]; other site 1064539003565 Walker B motif; other site 1064539003566 arginine finger; other site 1064539003567 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539003568 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1064539003569 flagellar motor switch protein; Reviewed; Region: PRK08916 1064539003570 flagellar assembly protein H; Validated; Region: fliH; PRK06032 1064539003571 Flagellar assembly protein FliH; Region: FliH; pfam02108 1064539003572 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1064539003573 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1064539003574 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1064539003575 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539003576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539003577 non-specific DNA binding site [nucleotide binding]; other site 1064539003578 salt bridge; other site 1064539003579 sequence-specific DNA binding site [nucleotide binding]; other site 1064539003580 hypothetical protein; Provisional; Region: PRK08912 1064539003581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539003582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539003583 homodimer interface [polypeptide binding]; other site 1064539003584 catalytic residue [active] 1064539003585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539003586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539003587 dimer interface [polypeptide binding]; other site 1064539003588 phosphorylation site [posttranslational modification] 1064539003589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539003590 ATP binding site [chemical binding]; other site 1064539003591 Mg2+ binding site [ion binding]; other site 1064539003592 G-X-G motif; other site 1064539003593 Evidence 4 : Homologs of previously reported genes of unknown function 1064539003594 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1064539003595 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1064539003596 Evidence 4 : Homologs of previously reported genes of unknown function 1064539003597 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1064539003598 DNA binding residues [nucleotide binding] 1064539003599 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1064539003600 putative dimer interface [polypeptide binding]; other site 1064539003601 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1064539003602 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1064539003603 dimer interface [polypeptide binding]; other site 1064539003604 active site 1064539003605 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1064539003606 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1064539003607 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1064539003608 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1064539003609 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1064539003610 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539003611 substrate binding site [chemical binding]; other site 1064539003612 oxyanion hole (OAH) forming residues; other site 1064539003613 trimer interface [polypeptide binding]; other site 1064539003614 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1064539003615 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1064539003616 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064539003617 active site 1064539003618 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1064539003619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539003620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539003621 active site 1064539003622 phosphorylation site [posttranslational modification] 1064539003623 intermolecular recognition site; other site 1064539003624 dimerization interface [polypeptide binding]; other site 1064539003625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539003626 DNA binding residues [nucleotide binding] 1064539003627 dimerization interface [polypeptide binding]; other site 1064539003628 FOG: CBS domain [General function prediction only]; Region: COG0517 1064539003629 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1064539003630 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1064539003631 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539003632 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539003633 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1064539003634 Walker A/P-loop; other site 1064539003635 ATP binding site [chemical binding]; other site 1064539003636 Q-loop/lid; other site 1064539003637 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1064539003638 ABC transporter signature motif; other site 1064539003639 Walker B; other site 1064539003640 D-loop; other site 1064539003641 H-loop/switch region; other site 1064539003642 Thioredoxin; Region: Thioredoxin_4; pfam13462 1064539003643 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1064539003644 Protein of unknown function (DUF721); Region: DUF721; cl02324 1064539003645 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1064539003646 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1064539003647 minor groove reading motif; other site 1064539003648 helix-hairpin-helix signature motif; other site 1064539003649 substrate binding pocket [chemical binding]; other site 1064539003650 active site 1064539003651 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1064539003652 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1064539003653 DNA binding and oxoG recognition site [nucleotide binding] 1064539003654 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1064539003655 metal ion-dependent adhesion site (MIDAS); other site 1064539003656 PAS domain S-box; Region: sensory_box; TIGR00229 1064539003657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539003658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539003659 ATP binding site [chemical binding]; other site 1064539003660 Mg2+ binding site [ion binding]; other site 1064539003661 G-X-G motif; other site 1064539003662 Dihydroneopterin aldolase; Region: FolB; smart00905 1064539003663 active site 1064539003664 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1064539003665 DNA methylase; Region: N6_N4_Mtase; pfam01555 1064539003666 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1064539003667 RNA/DNA hybrid binding site [nucleotide binding]; other site 1064539003668 active site 1064539003669 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539003670 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539003671 ligand binding site [chemical binding]; other site 1064539003672 flexible hinge region; other site 1064539003673 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539003674 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539003675 ligand binding site [chemical binding]; other site 1064539003676 flexible hinge region; other site 1064539003677 hypothetical protein; Provisional; Region: PRK02250 1064539003678 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539003679 DNA-binding site [nucleotide binding]; DNA binding site 1064539003680 RNA-binding motif; other site 1064539003681 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539003682 DNA-binding site [nucleotide binding]; DNA binding site 1064539003683 RNA-binding motif; other site 1064539003684 C-terminal peptidase (prc); Region: prc; TIGR00225 1064539003685 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1064539003686 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1064539003687 protein binding site [polypeptide binding]; other site 1064539003688 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1064539003689 Catalytic dyad [active] 1064539003690 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1064539003691 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1064539003692 dimerization interface [polypeptide binding]; other site 1064539003693 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1064539003694 ATP binding site [chemical binding]; other site 1064539003695 HupF/HypC family; Region: HupF_HypC; pfam01455 1064539003696 Acylphosphatase; Region: Acylphosphatase; pfam00708 1064539003697 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1064539003698 HypF finger; Region: zf-HYPF; pfam07503 1064539003699 HypF finger; Region: zf-HYPF; pfam07503 1064539003700 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1064539003701 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1064539003702 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539003703 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1064539003704 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1064539003705 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1064539003706 Rubredoxin; Region: Rubredoxin; pfam00301 1064539003707 iron binding site [ion binding]; other site 1064539003708 [NiFe] hydrogenase assembly chaperone, HybE family; Region: hydrog_HybE; TIGR03993 1064539003709 HupF/HypC family; Region: HupF_HypC; pfam01455 1064539003710 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1064539003711 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064539003712 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064539003713 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1064539003714 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1064539003715 putative substrate-binding site; other site 1064539003716 nickel binding site [ion binding]; other site 1064539003717 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1064539003718 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1064539003719 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1064539003720 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1064539003721 4Fe-4S binding domain; Region: Fer4; cl02805 1064539003722 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1064539003723 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1064539003724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539003725 dimerization interface [polypeptide binding]; other site 1064539003726 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539003727 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539003728 dimer interface [polypeptide binding]; other site 1064539003729 putative CheW interface [polypeptide binding]; other site 1064539003730 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1064539003731 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1064539003732 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1064539003733 active site 1064539003734 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1064539003735 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1064539003736 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1064539003737 EamA-like transporter family; Region: EamA; pfam00892 1064539003738 putative glutathione S-transferase; Provisional; Region: PRK10357 1064539003739 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1064539003740 putative C-terminal domain interface [polypeptide binding]; other site 1064539003741 putative GSH binding site (G-site) [chemical binding]; other site 1064539003742 putative dimer interface [polypeptide binding]; other site 1064539003743 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1064539003744 dimer interface [polypeptide binding]; other site 1064539003745 N-terminal domain interface [polypeptide binding]; other site 1064539003746 putative substrate binding pocket (H-site) [chemical binding]; other site 1064539003747 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1064539003748 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1064539003749 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1064539003750 PRC-barrel domain; Region: PRC; pfam05239 1064539003751 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539003752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539003753 S-adenosylmethionine binding site [chemical binding]; other site 1064539003754 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1064539003755 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1064539003756 hypothetical protein; Provisional; Region: PRK06034 1064539003757 Chorismate mutase type II; Region: CM_2; cl00693 1064539003758 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1064539003759 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539003760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539003761 homodimer interface [polypeptide binding]; other site 1064539003762 catalytic residue [active] 1064539003763 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 1064539003764 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1064539003765 NAD(P) binding site [chemical binding]; other site 1064539003766 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1064539003767 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1064539003768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539003769 non-specific DNA binding site [nucleotide binding]; other site 1064539003770 salt bridge; other site 1064539003771 sequence-specific DNA binding site [nucleotide binding]; other site 1064539003772 Cupin domain; Region: Cupin_2; pfam07883 1064539003773 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1064539003774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539003775 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1064539003776 dimerization interface [polypeptide binding]; other site 1064539003777 peroxiredoxin; Region: AhpC; TIGR03137 1064539003778 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1064539003779 dimer interface [polypeptide binding]; other site 1064539003780 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1064539003781 catalytic triad [active] 1064539003782 peroxidatic and resolving cysteines [active] 1064539003783 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1064539003784 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1064539003785 catalytic residue [active] 1064539003786 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1064539003787 catalytic residues [active] 1064539003788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064539003789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539003790 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539003791 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539003792 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1064539003793 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1064539003794 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1064539003795 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1064539003796 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1064539003797 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1064539003798 Cupin domain; Region: Cupin_2; cl17218 1064539003799 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1064539003800 Evidence 4 : Homologs of previously reported genes of unknown function 1064539003801 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1064539003802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539003803 active site 1064539003804 phosphorylation site [posttranslational modification] 1064539003805 intermolecular recognition site; other site 1064539003806 dimerization interface [polypeptide binding]; other site 1064539003807 Evidence 4 : Homologs of previously reported genes of unknown function 1064539003808 dihydroorotase; Validated; Region: PRK09059 1064539003809 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1064539003810 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1064539003811 active site 1064539003812 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1064539003813 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1064539003814 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1064539003815 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064539003816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539003817 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1064539003818 dimerization interface [polypeptide binding]; other site 1064539003819 substrate binding pocket [chemical binding]; other site 1064539003820 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1064539003821 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1064539003822 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1064539003823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539003824 S-adenosylmethionine binding site [chemical binding]; other site 1064539003825 Predicted permeases [General function prediction only]; Region: COG0679 1064539003826 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1064539003827 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1064539003828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539003829 Coenzyme A binding pocket [chemical binding]; other site 1064539003830 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539003831 dimerization interface [polypeptide binding]; other site 1064539003832 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539003833 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539003834 dimer interface [polypeptide binding]; other site 1064539003835 putative CheW interface [polypeptide binding]; other site 1064539003836 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1064539003837 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1064539003838 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1064539003839 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1064539003840 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1064539003841 GatB domain; Region: GatB_Yqey; smart00845 1064539003842 PAS domain S-box; Region: sensory_box; TIGR00229 1064539003843 PAS fold; Region: PAS_3; pfam08447 1064539003844 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1064539003845 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1064539003846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539003847 putative active site [active] 1064539003848 heme pocket [chemical binding]; other site 1064539003849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539003850 dimer interface [polypeptide binding]; other site 1064539003851 phosphorylation site [posttranslational modification] 1064539003852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539003853 ATP binding site [chemical binding]; other site 1064539003854 Mg2+ binding site [ion binding]; other site 1064539003855 G-X-G motif; other site 1064539003856 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1064539003857 active site 1064539003858 catalytic residues [active] 1064539003859 DNA binding site [nucleotide binding] 1064539003860 Int/Topo IB signature motif; other site 1064539003861 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 1064539003862 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1064539003863 putative C-terminal domain interface [polypeptide binding]; other site 1064539003864 putative GSH binding site [chemical binding]; other site 1064539003865 putative dimer interface [polypeptide binding]; other site 1064539003866 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 1064539003867 putative N-terminal domain interface [polypeptide binding]; other site 1064539003868 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1064539003869 Evidence 4 : Homologs of previously reported genes of unknown function 1064539003870 Evidence 4 : Homologs of previously reported genes of unknown function 1064539003871 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1064539003872 Protein of unknown function DUF58; Region: DUF58; pfam01882 1064539003873 MoxR-like ATPases [General function prediction only]; Region: COG0714 1064539003874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539003875 Walker A motif; other site 1064539003876 ATP binding site [chemical binding]; other site 1064539003877 Walker B motif; other site 1064539003878 arginine finger; other site 1064539003879 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1064539003880 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1064539003881 putative active site [active] 1064539003882 putative CoA binding site [chemical binding]; other site 1064539003883 nudix motif; other site 1064539003884 metal binding site [ion binding]; metal-binding site 1064539003885 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1064539003886 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1064539003887 active site 1064539003888 NTP binding site [chemical binding]; other site 1064539003889 metal binding triad [ion binding]; metal-binding site 1064539003890 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1064539003891 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1064539003892 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1064539003893 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1064539003894 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1064539003895 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1064539003896 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1064539003897 [2Fe-2S] cluster binding site [ion binding]; other site 1064539003898 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1647023, 2541921; Product type c : carrier 1064539003899 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1647023, 2541921; Product type c : carrier 1064539003900 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1064539003901 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539003902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539003903 active site 1064539003904 phosphorylation site [posttranslational modification] 1064539003905 intermolecular recognition site; other site 1064539003906 dimerization interface [polypeptide binding]; other site 1064539003907 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1064539003908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064539003909 dimerization interface [polypeptide binding]; other site 1064539003910 putative DNA binding site [nucleotide binding]; other site 1064539003911 putative Zn2+ binding site [ion binding]; other site 1064539003912 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1064539003913 CPxP motif; other site 1064539003914 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1064539003915 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1064539003916 putative active site [active] 1064539003917 Zn binding site [ion binding]; other site 1064539003918 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1064539003919 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1064539003920 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1064539003921 substrate binding pocket [chemical binding]; other site 1064539003922 chain length determination region; other site 1064539003923 substrate-Mg2+ binding site; other site 1064539003924 catalytic residues [active] 1064539003925 aspartate-rich region 1; other site 1064539003926 active site lid residues [active] 1064539003927 aspartate-rich region 2; other site 1064539003928 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1064539003929 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1064539003930 TPP-binding site; other site 1064539003931 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1064539003932 PYR/PP interface [polypeptide binding]; other site 1064539003933 dimer interface [polypeptide binding]; other site 1064539003934 TPP binding site [chemical binding]; other site 1064539003935 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064539003936 PAS fold; Region: PAS; pfam00989 1064539003937 PAS domain; Region: PAS; smart00091 1064539003938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1064539003939 Histidine kinase; Region: HisKA_2; pfam07568 1064539003940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539003941 ATP binding site [chemical binding]; other site 1064539003942 Mg2+ binding site [ion binding]; other site 1064539003943 G-X-G motif; other site 1064539003944 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1064539003945 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064539003946 RNA binding surface [nucleotide binding]; other site 1064539003947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539003948 S-adenosylmethionine binding site [chemical binding]; other site 1064539003949 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1064539003950 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 1064539003951 DDE superfamily endonuclease; Region: DDE_5; cl17874 1064539003952 Winged helix-turn helix; Region: HTH_29; pfam13551 1064539003953 Integrase core domain; Region: rve; pfam00665 1064539003954 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1064539003955 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539003956 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1064539003957 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1064539003958 catalytic residues [active] 1064539003959 catalytic nucleophile [active] 1064539003960 Presynaptic Site I dimer interface [polypeptide binding]; other site 1064539003961 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1064539003962 Synaptic Flat tetramer interface [polypeptide binding]; other site 1064539003963 Synaptic Site I dimer interface [polypeptide binding]; other site 1064539003964 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1064539003965 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1064539003966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1064539003967 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1064539003968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539003969 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1064539003970 Predicted transcriptional regulator [Transcription]; Region: COG1959 1064539003971 Transcriptional regulator; Region: Rrf2; pfam02082 1064539003972 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1064539003973 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064539003974 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1064539003975 active site 1064539003976 metal binding site [ion binding]; metal-binding site 1064539003977 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1064539003978 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1064539003979 short chain dehydrogenase; Provisional; Region: PRK06180 1064539003980 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1064539003981 NADP binding site [chemical binding]; other site 1064539003982 active site 1064539003983 steroid binding site; other site 1064539003984 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1064539003985 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064539003986 EthD domain; Region: EthD; cl17553 1064539003987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539003988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539003989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064539003990 dimerization interface [polypeptide binding]; other site 1064539003991 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539003992 Coenzyme A binding pocket [chemical binding]; other site 1064539003993 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539003994 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539003995 ligand binding site [chemical binding]; other site 1064539003996 flexible hinge region; other site 1064539003997 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1064539003998 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539003999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004000 active site 1064539004001 phosphorylation site [posttranslational modification] 1064539004002 intermolecular recognition site; other site 1064539004003 dimerization interface [polypeptide binding]; other site 1064539004004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539004005 dimer interface [polypeptide binding]; other site 1064539004006 phosphorylation site [posttranslational modification] 1064539004007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539004008 ATP binding site [chemical binding]; other site 1064539004009 Mg2+ binding site [ion binding]; other site 1064539004010 G-X-G motif; other site 1064539004011 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539004012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004013 active site 1064539004014 phosphorylation site [posttranslational modification] 1064539004015 intermolecular recognition site; other site 1064539004016 dimerization interface [polypeptide binding]; other site 1064539004017 putative transposase OrfB; Reviewed; Region: PHA02517 1064539004018 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 1064539004019 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1064539004020 catalytic residues [active] 1064539004021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1064539004022 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539004023 Ion channel; Region: Ion_trans_2; pfam07885 1064539004024 Major royal jelly protein; Region: MRJP; pfam03022 1064539004025 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1064539004026 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1064539004027 NAD binding site [chemical binding]; other site 1064539004028 catalytic Zn binding site [ion binding]; other site 1064539004029 structural Zn binding site [ion binding]; other site 1064539004030 PAS fold; Region: PAS_4; pfam08448 1064539004031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539004032 PAS fold; Region: PAS_3; pfam08447 1064539004033 putative active site [active] 1064539004034 heme pocket [chemical binding]; other site 1064539004035 PAS fold; Region: PAS_4; pfam08448 1064539004036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539004037 PAS fold; Region: PAS_3; pfam08447 1064539004038 putative active site [active] 1064539004039 heme pocket [chemical binding]; other site 1064539004040 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1064539004041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004042 active site 1064539004043 phosphorylation site [posttranslational modification] 1064539004044 intermolecular recognition site; other site 1064539004045 dimerization interface [polypeptide binding]; other site 1064539004046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539004047 dimerization interface [polypeptide binding]; other site 1064539004048 DNA binding residues [nucleotide binding] 1064539004049 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 1064539004050 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1064539004051 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1064539004052 NADP binding site [chemical binding]; other site 1064539004053 dimer interface [polypeptide binding]; other site 1064539004054 acyl-CoA synthetase; Validated; Region: PRK06164 1064539004055 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539004056 acyl-activating enzyme (AAE) consensus motif; other site 1064539004057 AMP binding site [chemical binding]; other site 1064539004058 active site 1064539004059 CoA binding site [chemical binding]; other site 1064539004060 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539004061 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539004062 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539004063 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539004064 Walker A/P-loop; other site 1064539004065 ATP binding site [chemical binding]; other site 1064539004066 Q-loop/lid; other site 1064539004067 ABC transporter signature motif; other site 1064539004068 Walker B; other site 1064539004069 D-loop; other site 1064539004070 H-loop/switch region; other site 1064539004071 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539004072 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539004073 Walker A/P-loop; other site 1064539004074 ATP binding site [chemical binding]; other site 1064539004075 Q-loop/lid; other site 1064539004076 ABC transporter signature motif; other site 1064539004077 Walker B; other site 1064539004078 D-loop; other site 1064539004079 H-loop/switch region; other site 1064539004080 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539004081 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539004082 TM-ABC transporter signature motif; other site 1064539004083 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539004084 TM-ABC transporter signature motif; other site 1064539004085 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1064539004086 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1064539004087 active site 1064539004088 catalytic site [active] 1064539004089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539004090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539004091 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539004092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539004093 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1064539004094 putative dimerization interface [polypeptide binding]; other site 1064539004095 putative effector binding pocket; other site 1064539004096 Beta-lactamase; Region: Beta-lactamase; pfam00144 1064539004097 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1064539004098 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1064539004099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539004100 putative substrate translocation pore; other site 1064539004101 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1064539004102 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1064539004103 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1064539004104 substrate binding pocket [chemical binding]; other site 1064539004105 NMT1/THI5 like; Region: NMT1; pfam09084 1064539004106 membrane-bound complex binding site; other site 1064539004107 hinge residues; other site 1064539004108 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539004109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539004110 dimer interface [polypeptide binding]; other site 1064539004111 conserved gate region; other site 1064539004112 putative PBP binding loops; other site 1064539004113 ABC-ATPase subunit interface; other site 1064539004114 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539004115 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539004116 Walker A/P-loop; other site 1064539004117 ATP binding site [chemical binding]; other site 1064539004118 Q-loop/lid; other site 1064539004119 ABC transporter signature motif; other site 1064539004120 Walker B; other site 1064539004121 D-loop; other site 1064539004122 H-loop/switch region; other site 1064539004123 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064539004124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539004125 DNA-binding site [nucleotide binding]; DNA binding site 1064539004126 FCD domain; Region: FCD; pfam07729 1064539004127 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1064539004128 cytosine deaminase; Provisional; Region: PRK05985 1064539004129 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1064539004130 active site 1064539004131 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 1064539004132 Evidence 5 : No homology to any previously reported sequences 1064539004133 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539004134 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539004135 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539004136 Evidence 5 : No homology to any previously reported sequences 1064539004137 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539004138 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1064539004139 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539004140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539004141 non-specific DNA binding site [nucleotide binding]; other site 1064539004142 salt bridge; other site 1064539004143 sequence-specific DNA binding site [nucleotide binding]; other site 1064539004144 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1064539004145 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1064539004146 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1064539004147 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1064539004148 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1064539004149 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1064539004150 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1064539004151 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1064539004152 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1064539004153 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1064539004154 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1064539004155 carboxyltransferase (CT) interaction site; other site 1064539004156 biotinylation site [posttranslational modification]; other site 1064539004157 BioY family; Region: BioY; pfam02632 1064539004158 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1064539004159 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1064539004160 active site 1064539004161 substrate binding site [chemical binding]; other site 1064539004162 coenzyme B12 binding site [chemical binding]; other site 1064539004163 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1064539004164 B12 binding site [chemical binding]; other site 1064539004165 cobalt ligand [ion binding]; other site 1064539004166 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 1064539004167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004168 TPR motif; other site 1064539004169 binding surface 1064539004170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539004171 binding surface 1064539004172 TPR motif; other site 1064539004173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004174 binding surface 1064539004175 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1064539004176 TPR motif; other site 1064539004177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004178 binding surface 1064539004179 TPR motif; other site 1064539004180 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1064539004181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004182 active site 1064539004183 phosphorylation site [posttranslational modification] 1064539004184 intermolecular recognition site; other site 1064539004185 dimerization interface [polypeptide binding]; other site 1064539004186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539004187 Walker A motif; other site 1064539004188 ATP binding site [chemical binding]; other site 1064539004189 Walker B motif; other site 1064539004190 arginine finger; other site 1064539004191 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539004192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539004193 dimer interface [polypeptide binding]; other site 1064539004194 phosphorylation site [posttranslational modification] 1064539004195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539004196 ATP binding site [chemical binding]; other site 1064539004197 Mg2+ binding site [ion binding]; other site 1064539004198 G-X-G motif; other site 1064539004199 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1064539004200 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1064539004201 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1064539004202 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1064539004203 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1064539004204 putative NAD(P) binding site [chemical binding]; other site 1064539004205 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1064539004206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004207 TPR motif; other site 1064539004208 TPR repeat; Region: TPR_11; pfam13414 1064539004209 binding surface 1064539004210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004211 binding surface 1064539004212 TPR motif; other site 1064539004213 TPR repeat; Region: TPR_11; pfam13414 1064539004214 Paraquat-inducible protein A; Region: PqiA; pfam04403 1064539004215 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1064539004216 Paraquat-inducible protein A; Region: PqiA; pfam04403 1064539004217 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1064539004218 mce related protein; Region: MCE; pfam02470 1064539004219 mce related protein; Region: MCE; pfam02470 1064539004220 mce related protein; Region: MCE; pfam02470 1064539004221 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1064539004222 Pyruvate formate lyase 1; Region: PFL1; cd01678 1064539004223 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1064539004224 coenzyme A binding site [chemical binding]; other site 1064539004225 active site 1064539004226 catalytic residues [active] 1064539004227 glycine loop; other site 1064539004228 PAS fold; Region: PAS; pfam00989 1064539004229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539004230 putative active site [active] 1064539004231 heme pocket [chemical binding]; other site 1064539004232 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1064539004233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539004234 Walker A motif; other site 1064539004235 ATP binding site [chemical binding]; other site 1064539004236 Walker B motif; other site 1064539004237 arginine finger; other site 1064539004238 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539004239 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1064539004240 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539004241 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539004242 DNA binding residues [nucleotide binding] 1064539004243 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 1064539004244 Putative zinc-finger; Region: zf-HC2; pfam13490 1064539004245 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1064539004246 DNA polymerase IV; Provisional; Region: PRK02794 1064539004247 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1064539004248 active site 1064539004249 DNA binding site [nucleotide binding] 1064539004250 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1064539004251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1064539004252 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1064539004253 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1064539004254 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1064539004255 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1064539004256 Clp amino terminal domain; Region: Clp_N; pfam02861 1064539004257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539004258 Walker A motif; other site 1064539004259 ATP binding site [chemical binding]; other site 1064539004260 Walker B motif; other site 1064539004261 arginine finger; other site 1064539004262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539004263 Walker A motif; other site 1064539004264 ATP binding site [chemical binding]; other site 1064539004265 Walker B motif; other site 1064539004266 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1064539004267 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1064539004268 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1064539004269 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1064539004270 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1064539004271 Protein of unknown function (DUF796); Region: DUF796; cl01226 1064539004272 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1064539004273 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1064539004274 Protein of unknown function (DUF770); Region: DUF770; cl01402 1064539004275 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1064539004276 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1064539004277 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539004278 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539004279 Sporulation related domain; Region: SPOR; pfam05036 1064539004280 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1064539004281 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1064539004282 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1064539004283 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1064539004284 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1064539004285 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1064539004286 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1064539004287 hypothetical protein; Provisional; Region: PRK05208 1064539004288 Cation transporter family protein; Region: LIC; TIGR00860 1064539004289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 1064539004290 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1064539004291 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1064539004292 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1064539004293 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1064539004294 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1064539004295 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539004296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539004297 putative PBP binding loops; other site 1064539004298 dimer interface [polypeptide binding]; other site 1064539004299 ABC-ATPase subunit interface; other site 1064539004300 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1064539004301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539004302 Walker A/P-loop; other site 1064539004303 ATP binding site [chemical binding]; other site 1064539004304 Q-loop/lid; other site 1064539004305 ABC transporter signature motif; other site 1064539004306 Walker B; other site 1064539004307 D-loop; other site 1064539004308 H-loop/switch region; other site 1064539004309 TOBE domain; Region: TOBE; cl01440 1064539004310 EamA-like transporter family; Region: EamA; pfam00892 1064539004311 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 1064539004312 pyruvate kinase; Provisional; Region: PRK06247 1064539004313 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1064539004314 domain interfaces; other site 1064539004315 active site 1064539004316 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064539004317 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064539004318 active site 1064539004319 catalytic tetrad [active] 1064539004320 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539004321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539004322 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1064539004323 putative effector binding pocket; other site 1064539004324 putative dimerization interface [polypeptide binding]; other site 1064539004325 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1064539004326 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1064539004327 active site 1064539004328 metal binding site [ion binding]; metal-binding site 1064539004329 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 1064539004330 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1064539004331 putative active site [active] 1064539004332 putative metal binding residues [ion binding]; other site 1064539004333 signature motif; other site 1064539004334 putative dimer interface [polypeptide binding]; other site 1064539004335 putative phosphate binding site [ion binding]; other site 1064539004336 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1064539004337 BON domain; Region: BON; pfam04972 1064539004338 Hemerythrin; Region: Hemerythrin; cd12107 1064539004339 Fe binding site [ion binding]; other site 1064539004340 Fic family protein [Function unknown]; Region: COG3177 1064539004341 Fic/DOC family; Region: Fic; pfam02661 1064539004342 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1064539004343 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1064539004344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064539004345 active site 1064539004346 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1064539004347 anti sigma factor interaction site; other site 1064539004348 regulatory phosphorylation site [posttranslational modification]; other site 1064539004349 potential frameshift: common BLAST hit: gi|374294306|ref|YP_005041331.1| putative ABC transporter, permease protein 1064539004350 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1064539004351 Permease; Region: Permease; pfam02405 1064539004352 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1064539004353 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1064539004354 Walker A/P-loop; other site 1064539004355 ATP binding site [chemical binding]; other site 1064539004356 Q-loop/lid; other site 1064539004357 ABC transporter signature motif; other site 1064539004358 Walker B; other site 1064539004359 D-loop; other site 1064539004360 H-loop/switch region; other site 1064539004361 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1064539004362 mce related protein; Region: MCE; pfam02470 1064539004363 Protein of unknown function (DUF330); Region: DUF330; cl01135 1064539004364 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1064539004365 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1064539004366 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539004367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539004368 DNA binding residues [nucleotide binding] 1064539004369 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1064539004370 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1064539004371 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1064539004372 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1064539004373 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539004374 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1064539004375 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1064539004376 dimer interface [polypeptide binding]; other site 1064539004377 active site 1064539004378 CoA binding pocket [chemical binding]; other site 1064539004379 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1064539004380 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1064539004381 [2Fe-2S] cluster binding site [ion binding]; other site 1064539004382 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1064539004383 alpha subunit interface [polypeptide binding]; other site 1064539004384 active site 1064539004385 substrate binding site [chemical binding]; other site 1064539004386 Fe binding site [ion binding]; other site 1064539004387 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1064539004388 classical (c) SDRs; Region: SDR_c; cd05233 1064539004389 NAD(P) binding site [chemical binding]; other site 1064539004390 active site 1064539004391 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 1064539004392 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1064539004393 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 1064539004394 Substrate binding site; other site 1064539004395 Mg++ binding site; other site 1064539004396 metal-binding site 1064539004397 Mg++ binding site; other site 1064539004398 metal-binding site 1064539004399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004400 binding surface 1064539004401 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539004402 TPR motif; other site 1064539004403 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539004404 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1064539004405 pseudaminic acid synthase; Region: PseI; TIGR03586 1064539004406 NeuB family; Region: NeuB; pfam03102 1064539004407 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1064539004408 NeuB binding interface [polypeptide binding]; other site 1064539004409 putative substrate binding site [chemical binding]; other site 1064539004410 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1064539004411 ligand binding site; other site 1064539004412 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1064539004413 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1064539004414 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1064539004415 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1064539004416 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539004417 acyl-activating enzyme (AAE) consensus motif; other site 1064539004418 AMP binding site [chemical binding]; other site 1064539004419 active site 1064539004420 CoA binding site [chemical binding]; other site 1064539004421 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1064539004422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539004423 NAD(P) binding site [chemical binding]; other site 1064539004424 active site 1064539004425 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1064539004426 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1064539004427 dimer interface [polypeptide binding]; other site 1064539004428 active site 1064539004429 CoA binding pocket [chemical binding]; other site 1064539004430 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1064539004431 Flagellar protein FlbT; Region: FlbT; cl11455 1064539004432 potential frameshift: common BLAST hit: gi|288960385|ref|YP_003450725.1| TPR repeat-containing protein 1064539004433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004434 TPR motif; other site 1064539004435 binding surface 1064539004436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004437 TPR motif; other site 1064539004438 binding surface 1064539004439 TPR repeat; Region: TPR_11; pfam13414 1064539004440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004441 binding surface 1064539004442 TPR motif; other site 1064539004443 TPR repeat; Region: TPR_11; pfam13414 1064539004444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004445 TPR motif; other site 1064539004446 TPR repeat; Region: TPR_11; pfam13414 1064539004447 binding surface 1064539004448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004449 TPR motif; other site 1064539004450 binding surface 1064539004451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004452 binding surface 1064539004453 TPR motif; other site 1064539004454 TPR repeat; Region: TPR_11; pfam13414 1064539004455 Protein of unknown function (DUF465); Region: DUF465; cl01070 1064539004456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004457 binding surface 1064539004458 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539004459 TPR motif; other site 1064539004460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004461 binding surface 1064539004462 TPR motif; other site 1064539004463 TPR repeat; Region: TPR_11; pfam13414 1064539004464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004465 binding surface 1064539004466 TPR motif; other site 1064539004467 TPR repeat; Region: TPR_11; pfam13414 1064539004468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004469 binding surface 1064539004470 TPR repeat; Region: TPR_11; pfam13414 1064539004471 TPR motif; other site 1064539004472 TPR repeat; Region: TPR_11; pfam13414 1064539004473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004474 binding surface 1064539004475 TPR repeat; Region: TPR_11; pfam13414 1064539004476 TPR motif; other site 1064539004477 TPR repeat; Region: TPR_11; pfam13414 1064539004478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004479 binding surface 1064539004480 TPR motif; other site 1064539004481 TPR repeat; Region: TPR_11; pfam13414 1064539004482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004483 TPR motif; other site 1064539004484 binding surface 1064539004485 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1064539004486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539004487 S-adenosylmethionine binding site [chemical binding]; other site 1064539004488 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1064539004489 BON domain; Region: BON; pfam04972 1064539004490 BON domain; Region: BON; pfam04972 1064539004491 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1064539004492 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1064539004493 active site 1064539004494 metal binding site [ion binding]; metal-binding site 1064539004495 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1064539004496 Protein of unknown function (DUF1386); Region: DUF1386; pfam07138 1064539004497 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1064539004498 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1064539004499 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1064539004500 putative active site [active] 1064539004501 putative substrate binding site [chemical binding]; other site 1064539004502 putative cosubstrate binding site; other site 1064539004503 catalytic site [active] 1064539004504 two-component response regulator; Provisional; Region: PRK09191 1064539004505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1064539004506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004507 active site 1064539004508 phosphorylation site [posttranslational modification] 1064539004509 intermolecular recognition site; other site 1064539004510 dimerization interface [polypeptide binding]; other site 1064539004511 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1064539004512 MarR family; Region: MarR; pfam01047 1064539004513 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539004514 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1064539004515 acyl-activating enzyme (AAE) consensus motif; other site 1064539004516 AMP binding site [chemical binding]; other site 1064539004517 active site 1064539004518 CoA binding site [chemical binding]; other site 1064539004519 Predicted membrane protein [Function unknown]; Region: COG2246 1064539004520 GtrA-like protein; Region: GtrA; pfam04138 1064539004521 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539004522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539004523 S-adenosylmethionine binding site [chemical binding]; other site 1064539004524 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 1064539004525 putative active site [active] 1064539004526 YdjC motif; other site 1064539004527 Mg binding site [ion binding]; other site 1064539004528 putative homodimer interface [polypeptide binding]; other site 1064539004529 imidazolonepropionase; Validated; Region: PRK09356 1064539004530 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1064539004531 active site 1064539004532 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1064539004533 putative active site [active] 1064539004534 homotetrameric interface [polypeptide binding]; other site 1064539004535 metal binding site [ion binding]; metal-binding site 1064539004536 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539004537 EamA-like transporter family; Region: EamA; pfam00892 1064539004538 urocanate hydratase; Provisional; Region: PRK05414 1064539004539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539004540 salt bridge; other site 1064539004541 non-specific DNA binding site [nucleotide binding]; other site 1064539004542 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539004543 sequence-specific DNA binding site [nucleotide binding]; other site 1064539004544 potential frameshift: common BLAST hit: gi|288958307|ref|YP_003448648.1| transcriptional regulator 1064539004545 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1064539004546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539004547 S-adenosylmethionine binding site [chemical binding]; other site 1064539004548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539004549 Coenzyme A binding pocket [chemical binding]; other site 1064539004550 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064539004551 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1064539004552 peptide binding site [polypeptide binding]; other site 1064539004553 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539004554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539004555 dimer interface [polypeptide binding]; other site 1064539004556 conserved gate region; other site 1064539004557 putative PBP binding loops; other site 1064539004558 ABC-ATPase subunit interface; other site 1064539004559 dipeptide transporter; Provisional; Region: PRK10913 1064539004560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539004561 dimer interface [polypeptide binding]; other site 1064539004562 conserved gate region; other site 1064539004563 putative PBP binding loops; other site 1064539004564 ABC-ATPase subunit interface; other site 1064539004565 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1064539004566 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539004567 Walker A/P-loop; other site 1064539004568 ATP binding site [chemical binding]; other site 1064539004569 Q-loop/lid; other site 1064539004570 ABC transporter signature motif; other site 1064539004571 Walker B; other site 1064539004572 D-loop; other site 1064539004573 H-loop/switch region; other site 1064539004574 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539004575 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1064539004576 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539004577 Walker A/P-loop; other site 1064539004578 ATP binding site [chemical binding]; other site 1064539004579 Q-loop/lid; other site 1064539004580 ABC transporter signature motif; other site 1064539004581 Walker B; other site 1064539004582 D-loop; other site 1064539004583 H-loop/switch region; other site 1064539004584 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539004585 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 1064539004586 Hemerythrin; Region: Hemerythrin; cd12107 1064539004587 Fe binding site [ion binding]; other site 1064539004588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1064539004589 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1064539004590 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1064539004591 Peptidase family M23; Region: Peptidase_M23; pfam01551 1064539004592 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539004593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004594 active site 1064539004595 phosphorylation site [posttranslational modification] 1064539004596 intermolecular recognition site; other site 1064539004597 dimerization interface [polypeptide binding]; other site 1064539004598 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1064539004599 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539004600 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539004601 DNA binding residues [nucleotide binding] 1064539004602 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539004603 PAS domain; Region: PAS_9; pfam13426 1064539004604 putative active site [active] 1064539004605 heme pocket [chemical binding]; other site 1064539004606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539004607 PAS domain; Region: PAS_9; pfam13426 1064539004608 putative active site [active] 1064539004609 heme pocket [chemical binding]; other site 1064539004610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539004611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539004612 metal binding site [ion binding]; metal-binding site 1064539004613 active site 1064539004614 I-site; other site 1064539004615 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539004616 potassium/proton antiporter; Reviewed; Region: PRK05326 1064539004617 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1064539004618 Transporter associated domain; Region: CorC_HlyC; smart01091 1064539004619 Gram-negative porin; Region: Porin_4; pfam13609 1064539004620 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1064539004621 hypothetical protein; Provisional; Region: PRK10279 1064539004622 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1064539004623 active site 1064539004624 nucleophile elbow; other site 1064539004625 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1064539004626 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539004627 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1064539004628 Walker A/P-loop; other site 1064539004629 ATP binding site [chemical binding]; other site 1064539004630 Q-loop/lid; other site 1064539004631 ABC transporter signature motif; other site 1064539004632 Walker B; other site 1064539004633 D-loop; other site 1064539004634 H-loop/switch region; other site 1064539004635 PAS domain S-box; Region: sensory_box; TIGR00229 1064539004636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539004637 putative active site [active] 1064539004638 heme pocket [chemical binding]; other site 1064539004639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539004640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539004641 dimer interface [polypeptide binding]; other site 1064539004642 phosphorylation site [posttranslational modification] 1064539004643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539004644 ATP binding site [chemical binding]; other site 1064539004645 Mg2+ binding site [ion binding]; other site 1064539004646 G-X-G motif; other site 1064539004647 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539004648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004649 active site 1064539004650 phosphorylation site [posttranslational modification] 1064539004651 intermolecular recognition site; other site 1064539004652 dimerization interface [polypeptide binding]; other site 1064539004653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539004654 binding surface 1064539004655 Putative phosphatase (DUF442); Region: DUF442; cl17385 1064539004656 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1064539004657 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539004658 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539004659 catalytic residue [active] 1064539004660 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1064539004661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1064539004662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539004663 S-adenosylmethionine binding site [chemical binding]; other site 1064539004664 LysR family transcriptional regulator; Provisional; Region: PRK14997 1064539004665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539004666 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1064539004667 putative effector binding pocket; other site 1064539004668 dimerization interface [polypeptide binding]; other site 1064539004669 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1064539004670 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1064539004671 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1064539004672 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1064539004673 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1064539004674 putative dimer interface [polypeptide binding]; other site 1064539004675 N-terminal domain interface [polypeptide binding]; other site 1064539004676 putative substrate binding pocket (H-site) [chemical binding]; other site 1064539004677 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539004678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004679 active site 1064539004680 phosphorylation site [posttranslational modification] 1064539004681 intermolecular recognition site; other site 1064539004682 dimerization interface [polypeptide binding]; other site 1064539004683 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1064539004684 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064539004685 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1064539004686 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1064539004687 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1064539004688 HSP70 interaction site [polypeptide binding]; other site 1064539004689 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1064539004690 substrate binding site [polypeptide binding]; other site 1064539004691 dimer interface [polypeptide binding]; other site 1064539004692 Peptidase family M48; Region: Peptidase_M48; cl12018 1064539004693 HAMP domain; Region: HAMP; pfam00672 1064539004694 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1064539004695 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1064539004696 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1064539004697 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1064539004698 active site 1064539004699 oxyanion hole [active] 1064539004700 Autotransporter beta-domain; Region: Autotransporter; smart00869 1064539004701 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064539004702 Ligand Binding Site [chemical binding]; other site 1064539004703 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064539004704 Ligand Binding Site [chemical binding]; other site 1064539004705 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1064539004706 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1064539004707 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1064539004708 putative dimer interface [polypeptide binding]; other site 1064539004709 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1064539004710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539004711 Walker A motif; other site 1064539004712 ATP binding site [chemical binding]; other site 1064539004713 Walker B motif; other site 1064539004714 arginine finger; other site 1064539004715 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1064539004716 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1064539004717 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1064539004718 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1064539004719 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1064539004720 Histidine kinase; Region: HisKA_2; pfam07568 1064539004721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539004722 ATP binding site [chemical binding]; other site 1064539004723 Mg2+ binding site [ion binding]; other site 1064539004724 G-X-G motif; other site 1064539004725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 1064539004726 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1064539004727 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1064539004728 LabA_like proteins; Region: LabA; cd10911 1064539004729 putative metal binding site [ion binding]; other site 1064539004730 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1064539004731 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1064539004732 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064539004733 Zn2+ binding site [ion binding]; other site 1064539004734 Mg2+ binding site [ion binding]; other site 1064539004735 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1064539004736 synthetase active site [active] 1064539004737 NTP binding site [chemical binding]; other site 1064539004738 metal binding site [ion binding]; metal-binding site 1064539004739 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1064539004740 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1064539004741 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1064539004742 nucleotide binding site/active site [active] 1064539004743 HIT family signature motif; other site 1064539004744 catalytic residue [active] 1064539004745 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1064539004746 active site 1064539004747 hydrophilic channel; other site 1064539004748 dimerization interface [polypeptide binding]; other site 1064539004749 catalytic residues [active] 1064539004750 active site lid [active] 1064539004751 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1064539004752 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1064539004753 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1064539004754 Catalytic site [active] 1064539004755 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1064539004756 ribonuclease III; Reviewed; Region: rnc; PRK00102 1064539004757 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1064539004758 dimerization interface [polypeptide binding]; other site 1064539004759 active site 1064539004760 metal binding site [ion binding]; metal-binding site 1064539004761 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1064539004762 dsRNA binding site [nucleotide binding]; other site 1064539004763 GTPase Era; Reviewed; Region: era; PRK00089 1064539004764 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1064539004765 G1 box; other site 1064539004766 GTP/Mg2+ binding site [chemical binding]; other site 1064539004767 Switch I region; other site 1064539004768 G2 box; other site 1064539004769 Switch II region; other site 1064539004770 G3 box; other site 1064539004771 G4 box; other site 1064539004772 G5 box; other site 1064539004773 KH domain; Region: KH_2; pfam07650 1064539004774 YcjX-like family, DUF463; Region: DUF463; pfam04317 1064539004775 hypothetical protein; Provisional; Region: PRK05415 1064539004776 Domain of unknown function (DUF697); Region: DUF697; cl12064 1064539004777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004778 binding surface 1064539004779 TPR motif; other site 1064539004780 TPR repeat; Region: TPR_11; pfam13414 1064539004781 TPR repeat; Region: TPR_11; pfam13414 1064539004782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004783 binding surface 1064539004784 TPR motif; other site 1064539004785 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1064539004786 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1064539004787 oligomer interface [polypeptide binding]; other site 1064539004788 active site residues [active] 1064539004789 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1064539004790 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1064539004791 active site 1064539004792 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1064539004793 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1064539004794 active site 1064539004795 metal binding site [ion binding]; metal-binding site 1064539004796 hexamer interface [polypeptide binding]; other site 1064539004797 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539004798 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539004799 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539004800 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1064539004801 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1064539004802 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1064539004803 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1064539004804 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1064539004805 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1064539004806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1064539004807 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1064539004808 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1064539004809 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1064539004810 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1064539004811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1064539004812 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1064539004813 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1064539004814 catalytic residues [active] 1064539004815 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 1064539004816 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1064539004817 active site 1064539004818 ATP binding site [chemical binding]; other site 1064539004819 substrate binding site [chemical binding]; other site 1064539004820 activation loop (A-loop); other site 1064539004821 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1064539004822 active site 1064539004823 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 1064539004824 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1064539004825 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 1064539004826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004827 binding surface 1064539004828 TPR motif; other site 1064539004829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539004830 binding surface 1064539004831 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539004832 TPR motif; other site 1064539004833 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539004834 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539004835 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1064539004836 OstA-like protein; Region: OstA; cl00844 1064539004837 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1064539004838 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1064539004839 AsnC family; Region: AsnC_trans_reg; pfam01037 1064539004840 helicase 45; Provisional; Region: PTZ00424 1064539004841 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1064539004842 ATP binding site [chemical binding]; other site 1064539004843 Mg++ binding site [ion binding]; other site 1064539004844 motif III; other site 1064539004845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539004846 nucleotide binding region [chemical binding]; other site 1064539004847 ATP-binding site [chemical binding]; other site 1064539004848 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1064539004849 Isochorismatase family; Region: Isochorismatase; pfam00857 1064539004850 catalytic triad [active] 1064539004851 dimer interface [polypeptide binding]; other site 1064539004852 conserved cis-peptide bond; other site 1064539004853 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1064539004854 TAP-like protein; Region: Abhydrolase_4; pfam08386 1064539004855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1064539004856 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1064539004857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539004858 Mg2+ binding site [ion binding]; other site 1064539004859 G-X-G motif; other site 1064539004860 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1064539004861 anchoring element; other site 1064539004862 dimer interface [polypeptide binding]; other site 1064539004863 ATP binding site [chemical binding]; other site 1064539004864 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1064539004865 active site 1064539004866 putative metal-binding site [ion binding]; other site 1064539004867 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1064539004868 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1064539004869 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1064539004870 Septum formation initiator; Region: DivIC; pfam04977 1064539004871 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1064539004872 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1064539004873 tetramer interface [polypeptide binding]; other site 1064539004874 TPP-binding site [chemical binding]; other site 1064539004875 heterodimer interface [polypeptide binding]; other site 1064539004876 phosphorylation loop region [posttranslational modification] 1064539004877 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 1064539004878 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1064539004879 E3 interaction surface; other site 1064539004880 lipoyl attachment site [posttranslational modification]; other site 1064539004881 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1064539004882 alpha subunit interface [polypeptide binding]; other site 1064539004883 TPP binding site [chemical binding]; other site 1064539004884 heterodimer interface [polypeptide binding]; other site 1064539004885 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064539004886 PAS fold; Region: PAS_7; pfam12860 1064539004887 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539004888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539004889 dimer interface [polypeptide binding]; other site 1064539004890 phosphorylation site [posttranslational modification] 1064539004891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539004892 ATP binding site [chemical binding]; other site 1064539004893 Mg2+ binding site [ion binding]; other site 1064539004894 G-X-G motif; other site 1064539004895 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539004896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004897 active site 1064539004898 phosphorylation site [posttranslational modification] 1064539004899 intermolecular recognition site; other site 1064539004900 dimerization interface [polypeptide binding]; other site 1064539004901 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064539004902 putative binding surface; other site 1064539004903 active site 1064539004904 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1064539004905 GAF domain; Region: GAF; pfam01590 1064539004906 PAS domain; Region: PAS_9; pfam13426 1064539004907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539004908 heme pocket [chemical binding]; other site 1064539004909 putative active site [active] 1064539004910 PAS domain S-box; Region: sensory_box; TIGR00229 1064539004911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539004912 putative active site [active] 1064539004913 heme pocket [chemical binding]; other site 1064539004914 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539004915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539004916 dimer interface [polypeptide binding]; other site 1064539004917 phosphorylation site [posttranslational modification] 1064539004918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539004919 ATP binding site [chemical binding]; other site 1064539004920 Mg2+ binding site [ion binding]; other site 1064539004921 G-X-G motif; other site 1064539004922 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539004923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004924 active site 1064539004925 phosphorylation site [posttranslational modification] 1064539004926 intermolecular recognition site; other site 1064539004927 dimerization interface [polypeptide binding]; other site 1064539004928 Hpt domain; Region: Hpt; pfam01627 1064539004929 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1064539004930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004931 active site 1064539004932 phosphorylation site [posttranslational modification] 1064539004933 intermolecular recognition site; other site 1064539004934 dimerization interface [polypeptide binding]; other site 1064539004935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539004936 Walker A motif; other site 1064539004937 ATP binding site [chemical binding]; other site 1064539004938 Walker B motif; other site 1064539004939 arginine finger; other site 1064539004940 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539004941 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539004942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004943 active site 1064539004944 phosphorylation site [posttranslational modification] 1064539004945 intermolecular recognition site; other site 1064539004946 dimerization interface [polypeptide binding]; other site 1064539004947 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1064539004948 PAS domain S-box; Region: sensory_box; TIGR00229 1064539004949 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539004950 putative active site [active] 1064539004951 heme pocket [chemical binding]; other site 1064539004952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539004953 dimer interface [polypeptide binding]; other site 1064539004954 phosphorylation site [posttranslational modification] 1064539004955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539004956 ATP binding site [chemical binding]; other site 1064539004957 Mg2+ binding site [ion binding]; other site 1064539004958 G-X-G motif; other site 1064539004959 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539004960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004961 active site 1064539004962 phosphorylation site [posttranslational modification] 1064539004963 intermolecular recognition site; other site 1064539004964 dimerization interface [polypeptide binding]; other site 1064539004965 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 1064539004966 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064539004967 putative binding surface; other site 1064539004968 active site 1064539004969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004970 active site 1064539004971 phosphorylation site [posttranslational modification] 1064539004972 intermolecular recognition site; other site 1064539004973 dimerization interface [polypeptide binding]; other site 1064539004974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539004975 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539004976 active site 1064539004977 phosphorylation site [posttranslational modification] 1064539004978 intermolecular recognition site; other site 1064539004979 dimerization interface [polypeptide binding]; other site 1064539004980 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539004981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539004982 metal binding site [ion binding]; metal-binding site 1064539004983 active site 1064539004984 I-site; other site 1064539004985 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1064539004986 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1064539004987 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1064539004988 anti sigma factor interaction site; other site 1064539004989 regulatory phosphorylation site [posttranslational modification]; other site 1064539004990 Bacterial sugar transferase; Region: Bac_transf; cl00939 1064539004991 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1064539004992 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1064539004993 Predicted integral membrane protein [Function unknown]; Region: COG5652 1064539004994 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1064539004995 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1064539004996 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1064539004997 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1064539004998 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539004999 active site 1064539005000 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1064539005001 N-terminal domain interface [polypeptide binding]; other site 1064539005002 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1064539005003 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1064539005004 active site 1064539005005 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1064539005006 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1064539005007 active site 1064539005008 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1064539005009 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539005010 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1064539005011 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1064539005012 DXD motif; other site 1064539005013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539005014 dimerization interface [polypeptide binding]; other site 1064539005015 potential frameshift: common BLAST hit: gi|170748155|ref|YP_001754415.1| alpha/beta hydrolase fold protein 1064539005016 TAP-like protein; Region: Abhydrolase_4; pfam08386 1064539005017 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1064539005018 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1064539005019 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1064539005020 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539005021 Walker A/P-loop; other site 1064539005022 ATP binding site [chemical binding]; other site 1064539005023 Q-loop/lid; other site 1064539005024 ABC transporter signature motif; other site 1064539005025 Walker B; other site 1064539005026 D-loop; other site 1064539005027 H-loop/switch region; other site 1064539005028 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539005029 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1064539005030 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539005031 Walker A/P-loop; other site 1064539005032 ATP binding site [chemical binding]; other site 1064539005033 Q-loop/lid; other site 1064539005034 ABC transporter signature motif; other site 1064539005035 Walker B; other site 1064539005036 D-loop; other site 1064539005037 H-loop/switch region; other site 1064539005038 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539005039 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1064539005040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005041 dimer interface [polypeptide binding]; other site 1064539005042 conserved gate region; other site 1064539005043 putative PBP binding loops; other site 1064539005044 ABC-ATPase subunit interface; other site 1064539005045 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539005046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005047 dimer interface [polypeptide binding]; other site 1064539005048 conserved gate region; other site 1064539005049 putative PBP binding loops; other site 1064539005050 ABC-ATPase subunit interface; other site 1064539005051 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064539005052 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 1064539005053 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064539005054 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1064539005055 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539005056 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 1064539005057 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1064539005058 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1064539005059 NADP binding site [chemical binding]; other site 1064539005060 dimer interface [polypeptide binding]; other site 1064539005061 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1064539005062 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539005063 substrate binding site [chemical binding]; other site 1064539005064 oxyanion hole (OAH) forming residues; other site 1064539005065 trimer interface [polypeptide binding]; other site 1064539005066 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1064539005067 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539005068 acyl-activating enzyme (AAE) consensus motif; other site 1064539005069 active site 1064539005070 AMP binding site [chemical binding]; other site 1064539005071 CoA binding site [chemical binding]; other site 1064539005072 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064539005073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005074 dimer interface [polypeptide binding]; other site 1064539005075 conserved gate region; other site 1064539005076 putative PBP binding loops; other site 1064539005077 ABC-ATPase subunit interface; other site 1064539005078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539005079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539005080 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1064539005081 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539005082 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1064539005083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539005084 Walker A/P-loop; other site 1064539005085 ATP binding site [chemical binding]; other site 1064539005086 Q-loop/lid; other site 1064539005087 ABC transporter signature motif; other site 1064539005088 Walker B; other site 1064539005089 D-loop; other site 1064539005090 H-loop/switch region; other site 1064539005091 TOBE domain; Region: TOBE_2; pfam08402 1064539005092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539005093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539005094 NnrS protein; Region: NnrS; pfam05940 1064539005095 NnrS protein; Region: NnrS; pfam05940 1064539005096 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539005097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539005098 Walker A/P-loop; other site 1064539005099 ATP binding site [chemical binding]; other site 1064539005100 Q-loop/lid; other site 1064539005101 ABC transporter signature motif; other site 1064539005102 Walker B; other site 1064539005103 D-loop; other site 1064539005104 H-loop/switch region; other site 1064539005105 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1064539005106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005107 dimer interface [polypeptide binding]; other site 1064539005108 conserved gate region; other site 1064539005109 putative PBP binding loops; other site 1064539005110 ABC-ATPase subunit interface; other site 1064539005111 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1064539005112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1064539005113 Integrase core domain; Region: rve_3; cl15866 1064539005114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539005115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539005116 CAAX protease self-immunity; Region: Abi; pfam02517 1064539005117 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1064539005118 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1064539005119 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1064539005120 Sulfatase; Region: Sulfatase; pfam00884 1064539005121 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1064539005122 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1064539005123 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1064539005124 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1064539005125 active site 1064539005126 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1064539005127 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1064539005128 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1064539005129 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1064539005130 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064539005131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539005132 DNA-binding site [nucleotide binding]; DNA binding site 1064539005133 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1064539005134 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064539005135 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064539005136 DNA binding site [nucleotide binding] 1064539005137 domain linker motif; other site 1064539005138 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1064539005139 putative ligand binding site [chemical binding]; other site 1064539005140 putative dimerization interface [polypeptide binding]; other site 1064539005141 Predicted deacylase [General function prediction only]; Region: COG3608 1064539005142 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1064539005143 active site 1064539005144 Zn binding site [ion binding]; other site 1064539005145 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1064539005146 homotrimer interaction site [polypeptide binding]; other site 1064539005147 putative active site [active] 1064539005148 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539005149 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539005150 substrate binding pocket [chemical binding]; other site 1064539005151 membrane-bound complex binding site; other site 1064539005152 hinge residues; other site 1064539005153 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1064539005154 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064539005155 Walker A/P-loop; other site 1064539005156 ATP binding site [chemical binding]; other site 1064539005157 Q-loop/lid; other site 1064539005158 ABC transporter signature motif; other site 1064539005159 Walker B; other site 1064539005160 D-loop; other site 1064539005161 H-loop/switch region; other site 1064539005162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539005163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005164 putative PBP binding loops; other site 1064539005165 dimer interface [polypeptide binding]; other site 1064539005166 ABC-ATPase subunit interface; other site 1064539005167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005168 dimer interface [polypeptide binding]; other site 1064539005169 conserved gate region; other site 1064539005170 putative PBP binding loops; other site 1064539005171 ABC-ATPase subunit interface; other site 1064539005172 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1064539005173 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1064539005174 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064539005175 catalytic residue [active] 1064539005176 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1064539005177 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064539005178 potential frameshift: common BLAST hit: gi|220924256|ref|YP_002499558.1| NAD-binding 6-phosphogluconate dehydrogenase 1064539005179 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1064539005180 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1064539005181 DctM-like transporters; Region: DctM; pfam06808 1064539005182 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1064539005183 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539005184 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539005185 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1064539005186 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1064539005187 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1064539005188 PYR/PP interface [polypeptide binding]; other site 1064539005189 dimer interface [polypeptide binding]; other site 1064539005190 TPP binding site [chemical binding]; other site 1064539005191 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064539005192 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1064539005193 TPP-binding site [chemical binding]; other site 1064539005194 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1064539005195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539005196 NAD(P) binding site [chemical binding]; other site 1064539005197 active site 1064539005198 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064539005199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539005200 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1064539005201 substrate binding pocket [chemical binding]; other site 1064539005202 dimerization interface [polypeptide binding]; other site 1064539005203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539005204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539005205 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1064539005206 acyl-CoA synthetase; Validated; Region: PRK06145 1064539005207 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539005208 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1064539005209 acyl-activating enzyme (AAE) consensus motif; other site 1064539005210 acyl-activating enzyme (AAE) consensus motif; other site 1064539005211 putative AMP binding site [chemical binding]; other site 1064539005212 putative active site [active] 1064539005213 putative CoA binding site [chemical binding]; other site 1064539005214 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539005215 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1064539005216 active site 1064539005217 e3 binding domain; Region: E3_binding; pfam02817 1064539005218 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1064539005219 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1064539005220 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1064539005221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539005222 substrate binding site [chemical binding]; other site 1064539005223 oxyanion hole (OAH) forming residues; other site 1064539005224 trimer interface [polypeptide binding]; other site 1064539005225 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1064539005226 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1064539005227 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1064539005228 alpha subunit interface [polypeptide binding]; other site 1064539005229 TPP binding site [chemical binding]; other site 1064539005230 heterodimer interface [polypeptide binding]; other site 1064539005231 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064539005232 potential frameshift: common BLAST hit: gi|33603678|ref|NP_891238.1| pyruvate dehydrogenase E1 component subunit alpha 1064539005233 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1064539005234 TPP-binding site [chemical binding]; other site 1064539005235 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1064539005236 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539005237 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539005238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539005239 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539005240 TM-ABC transporter signature motif; other site 1064539005241 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539005242 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539005243 TM-ABC transporter signature motif; other site 1064539005244 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539005245 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539005246 Walker A/P-loop; other site 1064539005247 ATP binding site [chemical binding]; other site 1064539005248 Q-loop/lid; other site 1064539005249 ABC transporter signature motif; other site 1064539005250 Walker B; other site 1064539005251 D-loop; other site 1064539005252 H-loop/switch region; other site 1064539005253 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539005254 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539005255 Walker A/P-loop; other site 1064539005256 ATP binding site [chemical binding]; other site 1064539005257 Q-loop/lid; other site 1064539005258 ABC transporter signature motif; other site 1064539005259 Walker B; other site 1064539005260 D-loop; other site 1064539005261 H-loop/switch region; other site 1064539005262 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1064539005263 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1064539005264 active site 1064539005265 dimer interface [polypeptide binding]; other site 1064539005266 metal binding site [ion binding]; metal-binding site 1064539005267 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1064539005268 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064539005269 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539005270 potential frameshift: common BLAST hit: gi|91780882|ref|YP_556089.1| putative thiolase 1064539005271 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1064539005272 active site 1064539005273 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1064539005274 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1064539005275 DUF35 OB-fold domain; Region: DUF35; pfam01796 1064539005276 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1064539005277 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1064539005278 active site 1064539005279 catalytic site [active] 1064539005280 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1064539005281 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539005282 substrate binding site [chemical binding]; other site 1064539005283 oxyanion hole (OAH) forming residues; other site 1064539005284 trimer interface [polypeptide binding]; other site 1064539005285 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539005286 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1064539005287 ligand binding site [chemical binding]; other site 1064539005288 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539005289 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539005290 TM-ABC transporter signature motif; other site 1064539005291 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539005292 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539005293 TM-ABC transporter signature motif; other site 1064539005294 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539005295 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539005296 Walker A/P-loop; other site 1064539005297 ATP binding site [chemical binding]; other site 1064539005298 Q-loop/lid; other site 1064539005299 ABC transporter signature motif; other site 1064539005300 Walker B; other site 1064539005301 D-loop; other site 1064539005302 H-loop/switch region; other site 1064539005303 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539005304 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539005305 Walker A/P-loop; other site 1064539005306 ATP binding site [chemical binding]; other site 1064539005307 Q-loop/lid; other site 1064539005308 ABC transporter signature motif; other site 1064539005309 Walker B; other site 1064539005310 D-loop; other site 1064539005311 H-loop/switch region; other site 1064539005312 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1064539005313 NAD(P) binding site [chemical binding]; other site 1064539005314 active site 1064539005315 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1064539005316 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539005317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539005318 acyl-activating enzyme (AAE) consensus motif; other site 1064539005319 AMP binding site [chemical binding]; other site 1064539005320 active site 1064539005321 CoA binding site [chemical binding]; other site 1064539005322 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1064539005323 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1064539005324 conserved cys residue [active] 1064539005325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539005326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539005327 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1064539005328 classical (c) SDRs; Region: SDR_c; cd05233 1064539005329 NAD(P) binding site [chemical binding]; other site 1064539005330 active site 1064539005331 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1064539005332 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1064539005333 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1064539005334 Secretin and TonB N terminus short domain; Region: STN; smart00965 1064539005335 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1064539005336 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539005337 N-terminal plug; other site 1064539005338 ligand-binding site [chemical binding]; other site 1064539005339 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1064539005340 FecR protein; Region: FecR; pfam04773 1064539005341 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1064539005342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539005343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539005344 DNA binding residues [nucleotide binding] 1064539005345 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539005346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539005347 DNA-binding site [nucleotide binding]; DNA binding site 1064539005348 FCD domain; Region: FCD; pfam07729 1064539005349 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1064539005350 DctM-like transporters; Region: DctM; pfam06808 1064539005351 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1064539005352 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1064539005353 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1064539005354 active site pocket [active] 1064539005355 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539005356 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539005357 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1064539005358 active site 1064539005359 nucleophile elbow; other site 1064539005360 Patatin phospholipase; Region: DUF3734; pfam12536 1064539005361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539005362 PAS domain; Region: PAS_9; pfam13426 1064539005363 putative active site [active] 1064539005364 heme pocket [chemical binding]; other site 1064539005365 PAS domain; Region: PAS_9; pfam13426 1064539005366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539005367 putative active site [active] 1064539005368 heme pocket [chemical binding]; other site 1064539005369 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539005370 PAS fold; Region: PAS_3; pfam08447 1064539005371 putative active site [active] 1064539005372 heme pocket [chemical binding]; other site 1064539005373 GAF domain; Region: GAF; pfam01590 1064539005374 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1064539005375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539005376 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1064539005377 putative active site [active] 1064539005378 heme pocket [chemical binding]; other site 1064539005379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539005380 dimer interface [polypeptide binding]; other site 1064539005381 phosphorylation site [posttranslational modification] 1064539005382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539005383 ATP binding site [chemical binding]; other site 1064539005384 Mg2+ binding site [ion binding]; other site 1064539005385 G-X-G motif; other site 1064539005386 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539005387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539005388 active site 1064539005389 phosphorylation site [posttranslational modification] 1064539005390 intermolecular recognition site; other site 1064539005391 dimerization interface [polypeptide binding]; other site 1064539005392 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1064539005393 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1064539005394 metal-binding site [ion binding] 1064539005395 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1064539005396 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1064539005397 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 1064539005398 Thioredoxin; Region: Thioredoxin_4; pfam13462 1064539005399 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1064539005400 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1064539005401 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1064539005402 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064539005403 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539005404 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1064539005405 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1064539005406 inhibitor site; inhibition site 1064539005407 active site 1064539005408 dimer interface [polypeptide binding]; other site 1064539005409 catalytic residue [active] 1064539005410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005411 dimer interface [polypeptide binding]; other site 1064539005412 conserved gate region; other site 1064539005413 putative PBP binding loops; other site 1064539005414 ABC-ATPase subunit interface; other site 1064539005415 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064539005416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005417 dimer interface [polypeptide binding]; other site 1064539005418 conserved gate region; other site 1064539005419 putative PBP binding loops; other site 1064539005420 ABC-ATPase subunit interface; other site 1064539005421 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1064539005422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539005423 Walker A/P-loop; other site 1064539005424 ATP binding site [chemical binding]; other site 1064539005425 Q-loop/lid; other site 1064539005426 ABC transporter signature motif; other site 1064539005427 Walker B; other site 1064539005428 D-loop; other site 1064539005429 H-loop/switch region; other site 1064539005430 TOBE domain; Region: TOBE_2; pfam08402 1064539005431 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1064539005432 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539005433 potential frameshift: common BLAST hit: gi|158424098|ref|YP_001525390.1| FAD dependent oxidoreductase 1064539005434 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1064539005435 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1064539005436 FAD binding domain; Region: FAD_binding_4; pfam01565 1064539005437 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1064539005438 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1064539005439 active site 1064539005440 Transposase domain (DUF772); Region: DUF772; pfam05598 1064539005441 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064539005442 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1064539005443 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1064539005444 Amidase; Region: Amidase; cl11426 1064539005445 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539005446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005447 dimer interface [polypeptide binding]; other site 1064539005448 conserved gate region; other site 1064539005449 putative PBP binding loops; other site 1064539005450 ABC-ATPase subunit interface; other site 1064539005451 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1064539005452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005453 dimer interface [polypeptide binding]; other site 1064539005454 conserved gate region; other site 1064539005455 putative PBP binding loops; other site 1064539005456 ABC-ATPase subunit interface; other site 1064539005457 Evidence 2b : Function of strongly homologous gene; PubMedId : 7536291; Product type t : transporter 1064539005458 Evidence 2b : Function of strongly homologous gene; PubMedId : 7536291; Product type t : transporter 1064539005459 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1064539005460 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539005461 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539005462 acyl-activating enzyme (AAE) consensus motif; other site 1064539005463 acyl-activating enzyme (AAE) consensus motif; other site 1064539005464 AMP binding site [chemical binding]; other site 1064539005465 active site 1064539005466 CoA binding site [chemical binding]; other site 1064539005467 EamA-like transporter family; Region: EamA; pfam00892 1064539005468 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539005469 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1064539005470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539005471 catalytic residue [active] 1064539005472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539005473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539005474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064539005475 dimerization interface [polypeptide binding]; other site 1064539005476 Isochorismatase family; Region: Isochorismatase; pfam00857 1064539005477 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1064539005478 catalytic triad [active] 1064539005479 conserved cis-peptide bond; other site 1064539005480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539005481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539005482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064539005483 dimerization interface [polypeptide binding]; other site 1064539005484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539005485 non-specific DNA binding site [nucleotide binding]; other site 1064539005486 salt bridge; other site 1064539005487 sequence-specific DNA binding site [nucleotide binding]; other site 1064539005488 GAF domain; Region: GAF_3; pfam13492 1064539005489 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064539005490 Zn2+ binding site [ion binding]; other site 1064539005491 Mg2+ binding site [ion binding]; other site 1064539005492 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1064539005493 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1064539005494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539005495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539005496 ATP binding site [chemical binding]; other site 1064539005497 Mg2+ binding site [ion binding]; other site 1064539005498 G-X-G motif; other site 1064539005499 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1064539005500 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1064539005501 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1064539005502 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 1064539005503 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1064539005504 malonyl-CoA synthase; Validated; Region: PRK07514 1064539005505 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 1064539005506 acyl-activating enzyme (AAE) consensus motif; other site 1064539005507 active site 1064539005508 AMP binding site [chemical binding]; other site 1064539005509 CoA binding site [chemical binding]; other site 1064539005510 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1064539005511 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1064539005512 NADP binding site [chemical binding]; other site 1064539005513 dimer interface [polypeptide binding]; other site 1064539005514 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064539005515 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1064539005516 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539005517 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1064539005518 putative ligand binding site [chemical binding]; other site 1064539005519 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1064539005520 Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108 1064539005521 NAD(P) binding site [chemical binding]; other site 1064539005522 catalytic residues [active] 1064539005523 catalytic residues [active] 1064539005524 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1064539005525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539005526 substrate binding site [chemical binding]; other site 1064539005527 oxyanion hole (OAH) forming residues; other site 1064539005528 trimer interface [polypeptide binding]; other site 1064539005529 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539005530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539005531 DNA-binding site [nucleotide binding]; DNA binding site 1064539005532 FCD domain; Region: FCD; pfam07729 1064539005533 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1064539005534 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539005535 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1064539005536 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1064539005537 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1064539005538 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 1064539005539 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1064539005540 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1064539005541 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 1064539005542 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1064539005543 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 1064539005544 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1064539005545 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1064539005546 conserved cys residue [active] 1064539005547 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539005548 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539005549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539005550 active site 1064539005551 phosphorylation site [posttranslational modification] 1064539005552 intermolecular recognition site; other site 1064539005553 dimerization interface [polypeptide binding]; other site 1064539005554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1064539005555 Histidine kinase; Region: HisKA_2; pfam07568 1064539005556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539005557 ATP binding site [chemical binding]; other site 1064539005558 Mg2+ binding site [ion binding]; other site 1064539005559 G-X-G motif; other site 1064539005560 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539005561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539005562 active site 1064539005563 phosphorylation site [posttranslational modification] 1064539005564 intermolecular recognition site; other site 1064539005565 dimerization interface [polypeptide binding]; other site 1064539005566 CHASE3 domain; Region: CHASE3; pfam05227 1064539005567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539005568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539005569 ATP binding site [chemical binding]; other site 1064539005570 Mg2+ binding site [ion binding]; other site 1064539005571 G-X-G motif; other site 1064539005572 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1064539005573 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1064539005574 active site 1064539005575 metal binding site [ion binding]; metal-binding site 1064539005576 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1064539005577 dimer interface [polypeptide binding]; other site 1064539005578 tetramer interface [polypeptide binding]; other site 1064539005579 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1064539005580 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1064539005581 active site 1064539005582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1064539005583 hypothetical protein; Provisional; Region: PRK09262 1064539005584 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1064539005585 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1064539005586 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064539005587 benzoate transport; Region: 2A0115; TIGR00895 1064539005588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539005589 putative substrate translocation pore; other site 1064539005590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539005591 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539005592 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539005593 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539005594 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539005595 TM-ABC transporter signature motif; other site 1064539005596 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539005597 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539005598 TM-ABC transporter signature motif; other site 1064539005599 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539005600 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539005601 Walker A/P-loop; other site 1064539005602 ATP binding site [chemical binding]; other site 1064539005603 Q-loop/lid; other site 1064539005604 ABC transporter signature motif; other site 1064539005605 Walker B; other site 1064539005606 D-loop; other site 1064539005607 H-loop/switch region; other site 1064539005608 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539005609 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539005610 Walker A/P-loop; other site 1064539005611 ATP binding site [chemical binding]; other site 1064539005612 Q-loop/lid; other site 1064539005613 ABC transporter signature motif; other site 1064539005614 Walker B; other site 1064539005615 D-loop; other site 1064539005616 H-loop/switch region; other site 1064539005617 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1064539005618 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539005619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539005620 active site 1064539005621 phosphorylation site [posttranslational modification] 1064539005622 intermolecular recognition site; other site 1064539005623 dimerization interface [polypeptide binding]; other site 1064539005624 Cache domain; Region: Cache_1; pfam02743 1064539005625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1064539005626 Histidine kinase; Region: HisKA_2; pfam07568 1064539005627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539005628 ATP binding site [chemical binding]; other site 1064539005629 Mg2+ binding site [ion binding]; other site 1064539005630 G-X-G motif; other site 1064539005631 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1064539005632 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1064539005633 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1064539005634 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1064539005635 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539005636 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539005637 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539005638 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1064539005639 Hemerythrin-like domain; Region: Hr-like; cd12108 1064539005640 PAS domain; Region: PAS_9; pfam13426 1064539005641 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1064539005642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539005643 Walker A motif; other site 1064539005644 ATP binding site [chemical binding]; other site 1064539005645 Walker B motif; other site 1064539005646 arginine finger; other site 1064539005647 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539005648 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 1064539005649 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1064539005650 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1064539005651 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1064539005652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539005653 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1064539005654 NAD(P) binding site [chemical binding]; other site 1064539005655 active site 1064539005656 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539005657 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1064539005658 putative ligand binding site [chemical binding]; other site 1064539005659 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1064539005660 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064539005661 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1064539005662 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1064539005663 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539005664 N-terminal plug; other site 1064539005665 ligand-binding site [chemical binding]; other site 1064539005666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539005667 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539005668 non-specific DNA binding site [nucleotide binding]; other site 1064539005669 salt bridge; other site 1064539005670 sequence-specific DNA binding site [nucleotide binding]; other site 1064539005671 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1064539005672 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539005673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539005674 non-specific DNA binding site [nucleotide binding]; other site 1064539005675 salt bridge; other site 1064539005676 sequence-specific DNA binding site [nucleotide binding]; other site 1064539005677 Cupin domain; Region: Cupin_2; pfam07883 1064539005678 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1064539005679 FAD binding domain; Region: FAD_binding_4; pfam01565 1064539005680 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1064539005681 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1064539005682 phosphate binding site [ion binding]; other site 1064539005683 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1064539005684 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1064539005685 inhibitor site; inhibition site 1064539005686 active site 1064539005687 dimer interface [polypeptide binding]; other site 1064539005688 catalytic residue [active] 1064539005689 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539005690 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539005691 substrate binding pocket [chemical binding]; other site 1064539005692 membrane-bound complex binding site; other site 1064539005693 hinge residues; other site 1064539005694 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064539005695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005696 dimer interface [polypeptide binding]; other site 1064539005697 conserved gate region; other site 1064539005698 putative PBP binding loops; other site 1064539005699 ABC-ATPase subunit interface; other site 1064539005700 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1064539005701 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064539005702 Walker A/P-loop; other site 1064539005703 ATP binding site [chemical binding]; other site 1064539005704 Q-loop/lid; other site 1064539005705 ABC transporter signature motif; other site 1064539005706 Walker B; other site 1064539005707 D-loop; other site 1064539005708 H-loop/switch region; other site 1064539005709 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1064539005710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539005711 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1064539005712 putative dimerization interface [polypeptide binding]; other site 1064539005713 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064539005714 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1064539005715 potential frameshift: common BLAST hit: gi|374999416|ref|YP_004974914.1| ABC transporter ATP-binding protein 1064539005716 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1064539005717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539005718 Walker A/P-loop; other site 1064539005719 ATP binding site [chemical binding]; other site 1064539005720 Q-loop/lid; other site 1064539005721 ABC transporter signature motif; other site 1064539005722 Walker B; other site 1064539005723 D-loop; other site 1064539005724 H-loop/switch region; other site 1064539005725 TOBE domain; Region: TOBE_2; pfam08402 1064539005726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005727 dimer interface [polypeptide binding]; other site 1064539005728 conserved gate region; other site 1064539005729 ABC-ATPase subunit interface; other site 1064539005730 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064539005731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005732 dimer interface [polypeptide binding]; other site 1064539005733 conserved gate region; other site 1064539005734 putative PBP binding loops; other site 1064539005735 ABC-ATPase subunit interface; other site 1064539005736 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1064539005737 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1064539005738 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064539005739 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1064539005740 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1064539005741 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1064539005742 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1064539005743 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064539005744 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1064539005745 homotrimer interaction site [polypeptide binding]; other site 1064539005746 putative active site [active] 1064539005747 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1064539005748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539005749 substrate binding pocket [chemical binding]; other site 1064539005750 membrane-bound complex binding site; other site 1064539005751 hinge residues; other site 1064539005752 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1064539005753 homotrimer interaction site [polypeptide binding]; other site 1064539005754 putative active site [active] 1064539005755 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1064539005756 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1064539005757 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1064539005758 active site 1064539005759 catalytic site [active] 1064539005760 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1064539005761 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1064539005762 DctM-like transporters; Region: DctM; pfam06808 1064539005763 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1064539005764 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1064539005765 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539005766 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539005767 potential frameshift: common BLAST hit: gi|99078004|ref|YP_611263.1| Beta-glucuronidase 1064539005768 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1064539005769 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1064539005770 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1064539005771 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064539005772 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064539005773 DNA binding site [nucleotide binding] 1064539005774 domain linker motif; other site 1064539005775 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1064539005776 dimerization interface [polypeptide binding]; other site 1064539005777 ligand binding site [chemical binding]; other site 1064539005778 potential frameshift: common BLAST hit: gi|316934547|ref|YP_004109529.1| heavy metal translocating P-type ATPase 1064539005779 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1064539005780 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1064539005781 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1064539005782 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1064539005783 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1064539005784 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1064539005785 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1064539005786 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539005787 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539005788 Walker A/P-loop; other site 1064539005789 ATP binding site [chemical binding]; other site 1064539005790 Q-loop/lid; other site 1064539005791 ABC transporter signature motif; other site 1064539005792 Walker B; other site 1064539005793 D-loop; other site 1064539005794 H-loop/switch region; other site 1064539005795 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539005796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005797 dimer interface [polypeptide binding]; other site 1064539005798 conserved gate region; other site 1064539005799 putative PBP binding loops; other site 1064539005800 ABC-ATPase subunit interface; other site 1064539005801 NMT1/THI5 like; Region: NMT1; pfam09084 1064539005802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539005803 substrate binding pocket [chemical binding]; other site 1064539005804 membrane-bound complex binding site; other site 1064539005805 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 1064539005806 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1064539005807 CHAT domain; Region: CHAT; pfam12770 1064539005808 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1064539005809 Calx-beta domain; Region: Calx-beta; cl02522 1064539005810 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1064539005811 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1064539005812 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1064539005813 potential frameshift: common BLAST hit: gi|83595044|ref|YP_428796.1| lipopolysaccharide biosynthesis protein 1064539005814 Chain length determinant protein; Region: Wzz; cl15801 1064539005815 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1064539005816 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1064539005817 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1064539005818 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1064539005819 SLBB domain; Region: SLBB; pfam10531 1064539005820 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1064539005821 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1064539005822 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1064539005823 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1064539005824 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1064539005825 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1064539005826 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1064539005827 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1064539005828 active site 1064539005829 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539005830 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1064539005831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539005832 DNA binding residues [nucleotide binding] 1064539005833 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1064539005834 potential frameshift: common BLAST hit: gi|374291703|ref|YP_005038738.1| putative FecR-like signal transducer for ferric citrate transport 1064539005835 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1064539005836 FecR protein; Region: FecR; pfam04773 1064539005837 Secretin and TonB N terminus short domain; Region: STN; smart00965 1064539005838 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1064539005839 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539005840 N-terminal plug; other site 1064539005841 ligand-binding site [chemical binding]; other site 1064539005842 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539005843 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539005844 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539005845 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1064539005846 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1064539005847 Walker A/P-loop; other site 1064539005848 ATP binding site [chemical binding]; other site 1064539005849 Q-loop/lid; other site 1064539005850 ABC transporter signature motif; other site 1064539005851 Walker B; other site 1064539005852 D-loop; other site 1064539005853 H-loop/switch region; other site 1064539005854 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1064539005855 FtsX-like permease family; Region: FtsX; pfam02687 1064539005856 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064539005857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539005858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539005859 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1064539005860 putative effector binding pocket; other site 1064539005861 putative dimerization interface [polypeptide binding]; other site 1064539005862 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1064539005863 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1064539005864 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1064539005865 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1064539005866 catalytic residues [active] 1064539005867 catalytic nucleophile [active] 1064539005868 Presynaptic Site I dimer interface [polypeptide binding]; other site 1064539005869 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1064539005870 Synaptic Flat tetramer interface [polypeptide binding]; other site 1064539005871 Synaptic Site I dimer interface [polypeptide binding]; other site 1064539005872 DNA binding site [nucleotide binding] 1064539005873 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1064539005874 DNA-binding interface [nucleotide binding]; DNA binding site 1064539005875 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 1064539005876 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1064539005877 active site 1064539005878 catalytic site [active] 1064539005879 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1064539005880 Protein of unknown function (DUF502); Region: DUF502; cl01107 1064539005881 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1064539005882 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1064539005883 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1064539005884 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539005885 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539005886 Ion channel; Region: Ion_trans_2; pfam07885 1064539005887 GAF domain; Region: GAF; pfam01590 1064539005888 cyclase homology domain; Region: CHD; cd07302 1064539005889 nucleotidyl binding site; other site 1064539005890 metal binding site [ion binding]; metal-binding site 1064539005891 dimer interface [polypeptide binding]; other site 1064539005892 Permease; Region: Permease; pfam02405 1064539005893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539005894 Walker A/P-loop; other site 1064539005895 ATP binding site [chemical binding]; other site 1064539005896 ABC transporter; Region: ABC_tran; pfam00005 1064539005897 Q-loop/lid; other site 1064539005898 ABC transporter signature motif; other site 1064539005899 Walker B; other site 1064539005900 D-loop; other site 1064539005901 H-loop/switch region; other site 1064539005902 mce related protein; Region: MCE; pfam02470 1064539005903 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 1064539005904 LssY C-terminus; Region: LssY_C; pfam14067 1064539005905 LssY C-terminus; Region: LssY_C; pfam14067 1064539005906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1064539005907 Homeodomain-like domain; Region: HTH_23; pfam13384 1064539005908 Winged helix-turn helix; Region: HTH_29; pfam13551 1064539005909 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1064539005910 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1064539005911 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1064539005912 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1064539005913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1064539005914 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1064539005915 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1064539005916 Predicted transcriptional regulators [Transcription]; Region: COG1733 1064539005917 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1064539005918 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1064539005919 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1064539005920 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1064539005921 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1064539005922 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1064539005923 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1064539005924 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1064539005925 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1064539005926 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 1064539005927 short chain dehydrogenase; Provisional; Region: PRK06482 1064539005928 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1064539005929 NADP binding site [chemical binding]; other site 1064539005930 active site 1064539005931 steroid binding site; other site 1064539005932 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539005933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539005934 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1064539005935 putative effector binding pocket; other site 1064539005936 putative dimerization interface [polypeptide binding]; other site 1064539005937 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064539005938 MarR family; Region: MarR_2; pfam12802 1064539005939 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539005940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539005941 NAD(P) binding site [chemical binding]; other site 1064539005942 active site 1064539005943 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539005944 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539005945 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1064539005946 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539005947 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539005948 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539005949 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539005950 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539005951 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539005952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539005953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539005954 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1064539005955 substrate binding pocket [chemical binding]; other site 1064539005956 dimerization interface [polypeptide binding]; other site 1064539005957 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1064539005958 ornithine decarboxylase; Provisional; Region: PRK13578 1064539005959 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1064539005960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539005961 catalytic residue [active] 1064539005962 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1064539005963 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1064539005964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539005965 Coenzyme A binding pocket [chemical binding]; other site 1064539005966 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1064539005967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539005968 NAD(P) binding site [chemical binding]; other site 1064539005969 active site 1064539005970 Predicted transcriptional regulators [Transcription]; Region: COG1733 1064539005971 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1064539005972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539005973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539005974 DNA-binding site [nucleotide binding]; DNA binding site 1064539005975 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1064539005976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539005977 DNA-binding site [nucleotide binding]; DNA binding site 1064539005978 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539005979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539005980 homodimer interface [polypeptide binding]; other site 1064539005981 catalytic residue [active] 1064539005982 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1064539005983 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 1064539005984 DNA binding residues [nucleotide binding] 1064539005985 dimer interface [polypeptide binding]; other site 1064539005986 putative metal binding site [ion binding]; other site 1064539005987 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1064539005988 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1064539005989 short chain dehydrogenase; Provisional; Region: PRK07577 1064539005990 classical (c) SDRs; Region: SDR_c; cd05233 1064539005991 NAD(P) binding site [chemical binding]; other site 1064539005992 active site 1064539005993 NMT1/THI5 like; Region: NMT1; pfam09084 1064539005994 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539005995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539005996 dimer interface [polypeptide binding]; other site 1064539005997 conserved gate region; other site 1064539005998 putative PBP binding loops; other site 1064539005999 ABC-ATPase subunit interface; other site 1064539006000 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539006001 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539006002 Walker A/P-loop; other site 1064539006003 ATP binding site [chemical binding]; other site 1064539006004 Q-loop/lid; other site 1064539006005 ABC transporter signature motif; other site 1064539006006 Walker B; other site 1064539006007 D-loop; other site 1064539006008 H-loop/switch region; other site 1064539006009 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1064539006010 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1064539006011 inhibitor site; inhibition site 1064539006012 active site 1064539006013 dimer interface [polypeptide binding]; other site 1064539006014 catalytic residue [active] 1064539006015 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1064539006016 BNR repeat-like domain; Region: BNR_2; pfam13088 1064539006017 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1064539006018 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1064539006019 putative active site [active] 1064539006020 metal binding site [ion binding]; metal-binding site 1064539006021 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1064539006022 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1064539006023 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064539006024 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539006025 DNA-binding site [nucleotide binding]; DNA binding site 1064539006026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539006027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539006028 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1064539006029 putative dimerization interface [polypeptide binding]; other site 1064539006030 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1064539006031 Amidase; Region: Amidase; cl11426 1064539006032 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1064539006033 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064539006034 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539006035 enoyl-CoA hydratase; Provisional; Region: PRK06127 1064539006036 substrate binding site [chemical binding]; other site 1064539006037 oxyanion hole (OAH) forming residues; other site 1064539006038 trimer interface [polypeptide binding]; other site 1064539006039 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1064539006040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539006041 substrate binding pocket [chemical binding]; other site 1064539006042 membrane-bound complex binding site; other site 1064539006043 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539006044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539006045 dimer interface [polypeptide binding]; other site 1064539006046 conserved gate region; other site 1064539006047 putative PBP binding loops; other site 1064539006048 ABC-ATPase subunit interface; other site 1064539006049 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539006050 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539006051 Walker A/P-loop; other site 1064539006052 ATP binding site [chemical binding]; other site 1064539006053 Q-loop/lid; other site 1064539006054 ABC transporter signature motif; other site 1064539006055 Walker B; other site 1064539006056 D-loop; other site 1064539006057 H-loop/switch region; other site 1064539006058 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 1064539006059 putative active site [active] 1064539006060 putative catalytic site [active] 1064539006061 short chain dehydrogenase; Provisional; Region: PRK06125 1064539006062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539006063 NAD(P) binding site [chemical binding]; other site 1064539006064 active site 1064539006065 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1064539006066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539006067 TPR motif; other site 1064539006068 binding surface 1064539006069 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539006070 TPR repeat; Region: TPR_11; pfam13414 1064539006071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539006072 binding surface 1064539006073 TPR motif; other site 1064539006074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539006075 binding surface 1064539006076 TPR motif; other site 1064539006077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539006078 binding surface 1064539006079 TPR motif; other site 1064539006080 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539006081 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539006082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539006083 TPR motif; other site 1064539006084 binding surface 1064539006085 TPR repeat; Region: TPR_11; pfam13414 1064539006086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539006087 TPR motif; other site 1064539006088 binding surface 1064539006089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539006090 binding surface 1064539006091 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539006092 TPR motif; other site 1064539006093 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1064539006094 catalytic residue [active] 1064539006095 Phage Tail Collar Domain; Region: Collar; pfam07484 1064539006096 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1064539006097 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1064539006098 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1064539006099 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1064539006100 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1064539006101 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1064539006102 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1064539006103 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1064539006104 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1064539006105 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1064539006106 active site 1064539006107 ATP binding site [chemical binding]; other site 1064539006108 substrate binding site [chemical binding]; other site 1064539006109 activation loop (A-loop); other site 1064539006110 AAA ATPase domain; Region: AAA_16; pfam13191 1064539006111 Predicted ATPase [General function prediction only]; Region: COG3899 1064539006112 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1064539006113 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1064539006114 PAS fold; Region: PAS_7; pfam12860 1064539006115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539006116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539006117 dimer interface [polypeptide binding]; other site 1064539006118 phosphorylation site [posttranslational modification] 1064539006119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539006120 ATP binding site [chemical binding]; other site 1064539006121 Mg2+ binding site [ion binding]; other site 1064539006122 G-X-G motif; other site 1064539006123 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1064539006124 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1064539006125 tetramer interface [polypeptide binding]; other site 1064539006126 active site 1064539006127 Mg2+/Mn2+ binding site [ion binding]; other site 1064539006128 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539006129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539006130 dimer interface [polypeptide binding]; other site 1064539006131 conserved gate region; other site 1064539006132 putative PBP binding loops; other site 1064539006133 ABC-ATPase subunit interface; other site 1064539006134 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539006135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539006136 dimer interface [polypeptide binding]; other site 1064539006137 conserved gate region; other site 1064539006138 putative PBP binding loops; other site 1064539006139 ABC-ATPase subunit interface; other site 1064539006140 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539006141 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539006142 Walker A/P-loop; other site 1064539006143 ATP binding site [chemical binding]; other site 1064539006144 Q-loop/lid; other site 1064539006145 ABC transporter signature motif; other site 1064539006146 Walker B; other site 1064539006147 D-loop; other site 1064539006148 H-loop/switch region; other site 1064539006149 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1064539006150 NMT1/THI5 like; Region: NMT1; pfam09084 1064539006151 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1064539006152 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1064539006153 hypothetical protein; Provisional; Region: PRK14812 1064539006154 substrate binding site [chemical binding]; other site 1064539006155 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1064539006156 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1064539006157 substrate binding site [chemical binding]; other site 1064539006158 ligand binding site [chemical binding]; other site 1064539006159 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1064539006160 tetramer interface [polypeptide binding]; other site 1064539006161 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1064539006162 active site 1064539006163 Mg2+/Mn2+ binding site [ion binding]; other site 1064539006164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539006165 DNA-binding site [nucleotide binding]; DNA binding site 1064539006166 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1064539006167 FCD domain; Region: FCD; pfam07729 1064539006168 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1064539006169 Proline racemase; Region: Pro_racemase; pfam05544 1064539006170 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064539006171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539006172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539006173 dimer interface [polypeptide binding]; other site 1064539006174 ABC-ATPase subunit interface; other site 1064539006175 putative PBP binding loops; other site 1064539006176 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1064539006177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539006178 dimer interface [polypeptide binding]; other site 1064539006179 conserved gate region; other site 1064539006180 putative PBP binding loops; other site 1064539006181 ABC-ATPase subunit interface; other site 1064539006182 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1064539006183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539006184 Walker A/P-loop; other site 1064539006185 ATP binding site [chemical binding]; other site 1064539006186 Q-loop/lid; other site 1064539006187 ABC transporter signature motif; other site 1064539006188 Walker B; other site 1064539006189 D-loop; other site 1064539006190 H-loop/switch region; other site 1064539006191 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1064539006192 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064539006193 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1064539006194 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1064539006195 conserved cys residue [active] 1064539006196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539006197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539006198 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539006199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539006200 active site 1064539006201 phosphorylation site [posttranslational modification] 1064539006202 intermolecular recognition site; other site 1064539006203 dimerization interface [polypeptide binding]; other site 1064539006204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539006205 DNA binding residues [nucleotide binding] 1064539006206 dimerization interface [polypeptide binding]; other site 1064539006207 Histidine kinase; Region: HisKA_3; pfam07730 1064539006208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539006209 ATP binding site [chemical binding]; other site 1064539006210 Mg2+ binding site [ion binding]; other site 1064539006211 G-X-G motif; other site 1064539006212 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1064539006213 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1064539006214 dimer interface [polypeptide binding]; other site 1064539006215 Trp docking motif [polypeptide binding]; other site 1064539006216 active site 1064539006217 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1064539006218 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539006219 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539006220 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539006221 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1064539006222 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064539006223 inhibitor-cofactor binding pocket; inhibition site 1064539006224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539006225 catalytic residue [active] 1064539006226 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1064539006227 active site 1064539006228 ATP binding site [chemical binding]; other site 1064539006229 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539006230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539006231 DNA-binding site [nucleotide binding]; DNA binding site 1064539006232 FCD domain; Region: FCD; pfam07729 1064539006233 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1064539006234 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1064539006235 putative C-terminal domain interface [polypeptide binding]; other site 1064539006236 putative GSH binding site (G-site) [chemical binding]; other site 1064539006237 putative dimer interface [polypeptide binding]; other site 1064539006238 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1064539006239 putative N-terminal domain interface [polypeptide binding]; other site 1064539006240 putative dimer interface [polypeptide binding]; other site 1064539006241 putative substrate binding pocket (H-site) [chemical binding]; other site 1064539006242 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1064539006243 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1064539006244 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1064539006245 FAD binding pocket [chemical binding]; other site 1064539006246 FAD binding motif [chemical binding]; other site 1064539006247 phosphate binding motif [ion binding]; other site 1064539006248 beta-alpha-beta structure motif; other site 1064539006249 NAD binding pocket [chemical binding]; other site 1064539006250 Heme binding pocket [chemical binding]; other site 1064539006251 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1064539006252 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064539006253 catalytic loop [active] 1064539006254 iron binding site [ion binding]; other site 1064539006255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1064539006256 SnoaL-like domain; Region: SnoaL_2; pfam12680 1064539006257 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539006258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539006259 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1064539006260 putative effector binding pocket; other site 1064539006261 putative dimerization interface [polypeptide binding]; other site 1064539006262 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8866023, 6320721; Product type e : enzyme 1064539006263 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8866023, 6320721; Product type e : enzyme 1064539006264 xylose isomerase; Provisional; Region: PRK05474 1064539006265 xylose isomerase; Region: xylose_isom_A; TIGR02630 1064539006266 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1064539006267 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064539006268 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1064539006269 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1064539006270 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1064539006271 AP (apurinic/apyrimidinic) site pocket; other site 1064539006272 DNA interaction; other site 1064539006273 Metal-binding active site; metal-binding site 1064539006274 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1064539006275 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1064539006276 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 1064539006277 putative ligand binding site [chemical binding]; other site 1064539006278 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539006279 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1064539006280 TM-ABC transporter signature motif; other site 1064539006281 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10428954, 7921236; Product type e : enzyme 1064539006282 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10428954, 7921236; Product type e : enzyme 1064539006283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064539006284 putative DNA binding site [nucleotide binding]; other site 1064539006285 dimerization interface [polypeptide binding]; other site 1064539006286 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1064539006287 putative Zn2+ binding site [ion binding]; other site 1064539006288 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1064539006289 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064539006290 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1064539006291 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539006292 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539006293 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1064539006294 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1064539006295 Walker A/P-loop; other site 1064539006296 ATP binding site [chemical binding]; other site 1064539006297 Q-loop/lid; other site 1064539006298 ABC transporter signature motif; other site 1064539006299 Walker B; other site 1064539006300 D-loop; other site 1064539006301 H-loop/switch region; other site 1064539006302 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1064539006303 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1064539006304 Walker A/P-loop; other site 1064539006305 ATP binding site [chemical binding]; other site 1064539006306 Q-loop/lid; other site 1064539006307 ABC transporter signature motif; other site 1064539006308 Walker B; other site 1064539006309 D-loop; other site 1064539006310 H-loop/switch region; other site 1064539006311 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064539006312 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1064539006313 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064539006314 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1064539006315 Integrase core domain; Region: rve; pfam00665 1064539006316 Integrase core domain; Region: rve_3; pfam13683 1064539006317 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1064539006318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539006319 Walker A/P-loop; other site 1064539006320 ATP binding site [chemical binding]; other site 1064539006321 Q-loop/lid; other site 1064539006322 ABC transporter signature motif; other site 1064539006323 Walker B; other site 1064539006324 D-loop; other site 1064539006325 H-loop/switch region; other site 1064539006326 TOBE domain; Region: TOBE_2; pfam08402 1064539006327 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1064539006328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539006329 dimer interface [polypeptide binding]; other site 1064539006330 conserved gate region; other site 1064539006331 putative PBP binding loops; other site 1064539006332 ABC-ATPase subunit interface; other site 1064539006333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539006334 dimer interface [polypeptide binding]; other site 1064539006335 conserved gate region; other site 1064539006336 putative PBP binding loops; other site 1064539006337 ABC-ATPase subunit interface; other site 1064539006338 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1064539006339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1064539006340 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1064539006341 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1064539006342 active site 1064539006343 iron coordination sites [ion binding]; other site 1064539006344 substrate binding pocket [chemical binding]; other site 1064539006345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539006346 binding surface 1064539006347 TPR motif; other site 1064539006348 TPR repeat; Region: TPR_11; pfam13414 1064539006349 TPR repeat; Region: TPR_11; pfam13414 1064539006350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539006351 binding surface 1064539006352 TPR motif; other site 1064539006353 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1064539006354 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1064539006355 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1064539006356 active site 1064539006357 iron coordination sites [ion binding]; other site 1064539006358 substrate binding pocket [chemical binding]; other site 1064539006359 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1064539006360 NMT1-like family; Region: NMT1_2; pfam13379 1064539006361 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1064539006362 active site residue [active] 1064539006363 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1064539006364 active site residue [active] 1064539006365 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1064539006366 active site residue [active] 1064539006367 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1064539006368 active site residue [active] 1064539006369 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1064539006370 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1064539006371 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1064539006372 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1064539006373 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1064539006374 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1064539006375 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1064539006376 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1064539006377 intersubunit interface [polypeptide binding]; other site 1064539006378 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1064539006379 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1064539006380 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1064539006381 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1064539006382 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539006383 DNA-binding site [nucleotide binding]; DNA binding site 1064539006384 UTRA domain; Region: UTRA; pfam07702 1064539006385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539006386 active site 1064539006387 phosphorylation site [posttranslational modification] 1064539006388 intermolecular recognition site; other site 1064539006389 dimerization interface [polypeptide binding]; other site 1064539006390 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539006391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539006392 active site 1064539006393 phosphorylation site [posttranslational modification] 1064539006394 intermolecular recognition site; other site 1064539006395 dimerization interface [polypeptide binding]; other site 1064539006396 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539006397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539006398 dimer interface [polypeptide binding]; other site 1064539006399 phosphorylation site [posttranslational modification] 1064539006400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539006401 ATP binding site [chemical binding]; other site 1064539006402 Mg2+ binding site [ion binding]; other site 1064539006403 G-X-G motif; other site 1064539006404 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539006405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539006406 active site 1064539006407 phosphorylation site [posttranslational modification] 1064539006408 intermolecular recognition site; other site 1064539006409 dimerization interface [polypeptide binding]; other site 1064539006410 PAS domain S-box; Region: sensory_box; TIGR00229 1064539006411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539006412 putative active site [active] 1064539006413 heme pocket [chemical binding]; other site 1064539006414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539006415 dimer interface [polypeptide binding]; other site 1064539006416 phosphorylation site [posttranslational modification] 1064539006417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539006418 ATP binding site [chemical binding]; other site 1064539006419 Mg2+ binding site [ion binding]; other site 1064539006420 G-X-G motif; other site 1064539006421 EamA-like transporter family; Region: EamA; pfam00892 1064539006422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539006423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539006424 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1064539006425 putative dimerization interface [polypeptide binding]; other site 1064539006426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1064539006427 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1064539006428 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1064539006429 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1064539006430 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1064539006431 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1064539006432 active site 2 [active] 1064539006433 active site 1 [active] 1064539006434 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1064539006435 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064539006436 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1064539006437 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1064539006438 tetramer interface [polypeptide binding]; other site 1064539006439 active site 1064539006440 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1064539006441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539006442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539006443 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1064539006444 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064539006445 catalytic loop [active] 1064539006446 iron binding site [ion binding]; other site 1064539006447 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1064539006448 Cytochrome P450; Region: p450; cl12078 1064539006449 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1064539006450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539006451 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1064539006452 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1064539006453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539006454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539006455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539006456 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1064539006457 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064539006458 dimerization interface [polypeptide binding]; other site 1064539006459 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539006460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539006461 short chain dehydrogenase; Provisional; Region: PRK06172 1064539006462 classical (c) SDRs; Region: SDR_c; cd05233 1064539006463 NAD(P) binding site [chemical binding]; other site 1064539006464 active site 1064539006465 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1064539006466 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1064539006467 dimer interface [polypeptide binding]; other site 1064539006468 active site 1064539006469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539006470 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539006471 putative substrate translocation pore; other site 1064539006472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539006473 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539006474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539006475 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1064539006476 putative effector binding pocket; other site 1064539006477 putative dimerization interface [polypeptide binding]; other site 1064539006478 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1064539006479 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539006480 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1064539006481 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1064539006482 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 1064539006483 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539006484 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539006485 ligand binding site [chemical binding]; other site 1064539006486 flexible hinge region; other site 1064539006487 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1064539006488 non-specific DNA interactions [nucleotide binding]; other site 1064539006489 DNA binding site [nucleotide binding] 1064539006490 sequence specific DNA binding site [nucleotide binding]; other site 1064539006491 putative cAMP binding site [chemical binding]; other site 1064539006492 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1064539006493 SCP-2 sterol transfer family; Region: SCP2; cl01225 1064539006494 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1064539006495 Peptidase family U32; Region: Peptidase_U32; pfam01136 1064539006496 putative protease; Provisional; Region: PRK15447 1064539006497 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1064539006498 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1064539006499 NnrS protein; Region: NnrS; pfam05940 1064539006500 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 1064539006501 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539006502 ligand binding site [chemical binding]; other site 1064539006503 flexible hinge region; other site 1064539006504 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1064539006505 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1064539006506 ApbE family; Region: ApbE; pfam02424 1064539006507 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1064539006508 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1064539006509 NosL; Region: NosL; pfam05573 1064539006510 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1064539006511 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1064539006512 Walker A/P-loop; other site 1064539006513 ATP binding site [chemical binding]; other site 1064539006514 Q-loop/lid; other site 1064539006515 ABC transporter signature motif; other site 1064539006516 Walker B; other site 1064539006517 D-loop; other site 1064539006518 H-loop/switch region; other site 1064539006519 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1064539006520 nitrous-oxide reductase; Validated; Region: PRK02888 1064539006521 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1064539006522 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1064539006523 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1064539006524 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1064539006525 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1064539006526 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1064539006527 diiron binding motif [ion binding]; other site 1064539006528 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539006529 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539006530 putative active site [active] 1064539006531 heme pocket [chemical binding]; other site 1064539006532 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539006533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539006534 putative active site [active] 1064539006535 heme pocket [chemical binding]; other site 1064539006536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539006537 dimer interface [polypeptide binding]; other site 1064539006538 phosphorylation site [posttranslational modification] 1064539006539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539006540 ATP binding site [chemical binding]; other site 1064539006541 Mg2+ binding site [ion binding]; other site 1064539006542 G-X-G motif; other site 1064539006543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539006544 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539006545 active site 1064539006546 phosphorylation site [posttranslational modification] 1064539006547 intermolecular recognition site; other site 1064539006548 dimerization interface [polypeptide binding]; other site 1064539006549 Evidence 4 : Homologs of previously reported genes of unknown function 1064539006550 Evidence 4 : Homologs of previously reported genes of unknown function 1064539006551 Evidence 2b : Function of strongly homologous gene; PubMedId : 8465200; Product type f : factor 1064539006552 Evidence 2b : Function of strongly homologous gene; PubMedId : 8465200; Product type f : factor 1064539006553 Ion channel; Region: Ion_trans_2; pfam07885 1064539006554 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1064539006555 TrkA-N domain; Region: TrkA_N; pfam02254 1064539006556 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1064539006557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1064539006558 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 1064539006559 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064539006560 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1064539006561 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1064539006562 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539006563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539006564 NAD(P) binding site [chemical binding]; other site 1064539006565 active site 1064539006566 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 1064539006567 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1064539006568 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1064539006569 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539006570 FeS/SAM binding site; other site 1064539006571 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539006572 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539006573 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539006574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1064539006575 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1064539006576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1064539006577 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1064539006578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1064539006579 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1064539006580 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1064539006581 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1064539006582 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539006583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539006584 heme pocket [chemical binding]; other site 1064539006585 putative active site [active] 1064539006586 PAS domain S-box; Region: sensory_box; TIGR00229 1064539006587 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539006588 putative active site [active] 1064539006589 heme pocket [chemical binding]; other site 1064539006590 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539006591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539006592 putative active site [active] 1064539006593 heme pocket [chemical binding]; other site 1064539006594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539006595 dimer interface [polypeptide binding]; other site 1064539006596 phosphorylation site [posttranslational modification] 1064539006597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539006598 ATP binding site [chemical binding]; other site 1064539006599 Mg2+ binding site [ion binding]; other site 1064539006600 G-X-G motif; other site 1064539006601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539006602 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539006603 active site 1064539006604 phosphorylation site [posttranslational modification] 1064539006605 intermolecular recognition site; other site 1064539006606 dimerization interface [polypeptide binding]; other site 1064539006607 Transposase domain (DUF772); Region: DUF772; pfam05598 1064539006608 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1064539006609 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1064539006610 active site 1064539006611 nucleophile elbow; other site 1064539006612 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1064539006613 Citrate transporter; Region: CitMHS; pfam03600 1064539006614 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539006615 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539006616 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539006617 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1064539006618 Protein of unknown function (DUF983); Region: DUF983; cl02211 1064539006619 Transposase domain (DUF772); Region: DUF772; pfam05598 1064539006620 Cupin domain; Region: Cupin_2; pfam07883 1064539006621 SnoaL-like domain; Region: SnoaL_2; pfam12680 1064539006622 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 1064539006623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539006624 binding surface 1064539006625 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1064539006626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539006627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539006628 DNA binding residues [nucleotide binding] 1064539006629 Flagellar protein FliS; Region: FliS; cl00654 1064539006630 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1064539006631 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1064539006632 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1064539006633 flagellin; Provisional; Region: PRK12802 1064539006634 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1064539006635 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1064539006636 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 1064539006637 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1064539006638 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1064539006639 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 1064539006640 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 1064539006641 potential frameshift: common BLAST hit: gi|374294036|ref|YP_005041059.1| putative flagellar hook protein FlgE-like 1064539006642 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1064539006643 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064539006644 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1064539006645 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1064539006646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539006647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539006648 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1064539006649 putative dimerization interface [polypeptide binding]; other site 1064539006650 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1064539006651 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1064539006652 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539006653 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539006654 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539006655 TM-ABC transporter signature motif; other site 1064539006656 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539006657 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539006658 TM-ABC transporter signature motif; other site 1064539006659 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539006660 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539006661 Walker A/P-loop; other site 1064539006662 ATP binding site [chemical binding]; other site 1064539006663 Q-loop/lid; other site 1064539006664 ABC transporter signature motif; other site 1064539006665 Walker B; other site 1064539006666 D-loop; other site 1064539006667 H-loop/switch region; other site 1064539006668 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539006669 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539006670 Walker A/P-loop; other site 1064539006671 ATP binding site [chemical binding]; other site 1064539006672 Q-loop/lid; other site 1064539006673 ABC transporter signature motif; other site 1064539006674 Walker B; other site 1064539006675 D-loop; other site 1064539006676 H-loop/switch region; other site 1064539006677 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1064539006678 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 1064539006679 NAD(P) binding site [chemical binding]; other site 1064539006680 catalytic residues [active] 1064539006681 catalytic residues [active] 1064539006682 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1064539006683 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1064539006684 active site 1064539006685 NAD binding site [chemical binding]; other site 1064539006686 metal binding site [ion binding]; metal-binding site 1064539006687 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1064539006688 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1064539006689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539006690 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1064539006691 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1064539006692 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1064539006693 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1064539006694 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539006695 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539006696 Integrase core domain; Region: rve; pfam00665 1064539006697 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1064539006698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539006699 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539006700 non-specific DNA binding site [nucleotide binding]; other site 1064539006701 salt bridge; other site 1064539006702 sequence-specific DNA binding site [nucleotide binding]; other site 1064539006703 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1064539006704 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1064539006705 TAP-like protein; Region: Abhydrolase_4; pfam08386 1064539006706 SnoaL-like domain; Region: SnoaL_2; pfam12680 1064539006707 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539006708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539006709 non-specific DNA binding site [nucleotide binding]; other site 1064539006710 salt bridge; other site 1064539006711 sequence-specific DNA binding site [nucleotide binding]; other site 1064539006712 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1064539006713 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1064539006714 catalytic residues [active] 1064539006715 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1064539006716 Baseplate J-like protein; Region: Baseplate_J; cl01294 1064539006717 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1064539006718 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1064539006719 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 1064539006720 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1064539006721 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 1064539006722 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1064539006723 nudix motif; other site 1064539006724 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1064539006725 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1064539006726 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1064539006727 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1064539006728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 1064539006729 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1064539006730 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 1064539006731 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1064539006732 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1064539006733 catalytic residues [active] 1064539006734 catalytic nucleophile [active] 1064539006735 Presynaptic Site I dimer interface [polypeptide binding]; other site 1064539006736 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1064539006737 Synaptic Flat tetramer interface [polypeptide binding]; other site 1064539006738 Synaptic Site I dimer interface [polypeptide binding]; other site 1064539006739 DNA binding site [nucleotide binding] 1064539006740 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1064539006741 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1064539006742 catalytic residues [active] 1064539006743 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 1064539006744 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 1064539006745 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1064539006746 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1064539006747 active site 1064539006748 putative acetyltransferase; Provisional; Region: PRK03624 1064539006749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539006750 Coenzyme A binding pocket [chemical binding]; other site 1064539006751 MT-A70; Region: MT-A70; cl01947 1064539006752 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1064539006753 DNA methylase; Region: N6_N4_Mtase; pfam01555 1064539006754 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1064539006755 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539006756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539006757 non-specific DNA binding site [nucleotide binding]; other site 1064539006758 salt bridge; other site 1064539006759 sequence-specific DNA binding site [nucleotide binding]; other site 1064539006760 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 1064539006761 HNH endonuclease; Region: HNH_3; pfam13392 1064539006762 DNA polymerase III subunit beta; Validated; Region: PRK05643 1064539006763 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1064539006764 putative DNA binding surface [nucleotide binding]; other site 1064539006765 dimer interface [polypeptide binding]; other site 1064539006766 beta-clamp/clamp loader binding surface; other site 1064539006767 beta-clamp/translesion DNA polymerase binding surface; other site 1064539006768 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1064539006769 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1064539006770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539006771 dimerization interface [polypeptide binding]; other site 1064539006772 DNA binding residues [nucleotide binding] 1064539006773 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539006774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539006775 DNA binding residues [nucleotide binding] 1064539006776 dimerization interface [polypeptide binding]; other site 1064539006777 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539006778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539006779 non-specific DNA binding site [nucleotide binding]; other site 1064539006780 salt bridge; other site 1064539006781 sequence-specific DNA binding site [nucleotide binding]; other site 1064539006782 Ribbon-helix-helix domain; Region: RHH_4; cl01775 1064539006783 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539006784 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539006785 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1064539006786 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1064539006787 active site 1064539006788 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1064539006789 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1064539006790 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1064539006791 active site 1064539006792 catalytic residues [active] 1064539006793 DNA binding site [nucleotide binding] 1064539006794 Int/Topo IB signature motif; other site 1064539006795 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1064539006796 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1064539006797 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1064539006798 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539006799 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1064539006800 Walker A/P-loop; other site 1064539006801 ATP binding site [chemical binding]; other site 1064539006802 Q-loop/lid; other site 1064539006803 ABC transporter signature motif; other site 1064539006804 Walker B; other site 1064539006805 D-loop; other site 1064539006806 H-loop/switch region; other site 1064539006807 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1064539006808 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1064539006809 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1064539006810 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1064539006811 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1064539006812 Secretin and TonB N terminus short domain; Region: STN; smart00965 1064539006813 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1064539006814 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539006815 N-terminal plug; other site 1064539006816 ligand-binding site [chemical binding]; other site 1064539006817 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1064539006818 FecR protein; Region: FecR; pfam04773 1064539006819 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1064539006820 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539006821 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539006822 DNA binding residues [nucleotide binding] 1064539006823 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539006824 potential frameshift: common BLAST hit: gi|307155120|ref|YP_003890504.1| C-methyltransferase 1064539006825 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539006826 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1064539006827 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1064539006828 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1064539006829 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1064539006830 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539006831 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1064539006832 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064539006833 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1064539006834 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1064539006835 NAD(P) binding site [chemical binding]; other site 1064539006836 catalytic residues [active] 1064539006837 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1064539006838 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064539006839 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539006840 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1064539006841 putative ligand binding site [chemical binding]; other site 1064539006842 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539006843 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1064539006844 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064539006845 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064539006846 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1064539006847 active site 1064539006848 enoyl-CoA hydratase; Provisional; Region: PRK09245 1064539006849 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539006850 substrate binding site [chemical binding]; other site 1064539006851 oxyanion hole (OAH) forming residues; other site 1064539006852 trimer interface [polypeptide binding]; other site 1064539006853 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539006854 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539006855 Walker A/P-loop; other site 1064539006856 ATP binding site [chemical binding]; other site 1064539006857 Q-loop/lid; other site 1064539006858 ABC transporter signature motif; other site 1064539006859 Walker B; other site 1064539006860 D-loop; other site 1064539006861 H-loop/switch region; other site 1064539006862 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539006863 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539006864 Walker A/P-loop; other site 1064539006865 ATP binding site [chemical binding]; other site 1064539006866 Q-loop/lid; other site 1064539006867 ABC transporter signature motif; other site 1064539006868 Walker B; other site 1064539006869 D-loop; other site 1064539006870 H-loop/switch region; other site 1064539006871 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 1064539006872 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1064539006873 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1064539006874 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 1064539006875 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1064539006876 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1064539006877 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539006878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539006879 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1064539006880 Walker A/P-loop; other site 1064539006881 ATP binding site [chemical binding]; other site 1064539006882 Q-loop/lid; other site 1064539006883 ABC transporter signature motif; other site 1064539006884 Walker B; other site 1064539006885 D-loop; other site 1064539006886 H-loop/switch region; other site 1064539006887 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1064539006888 putative FMN binding site [chemical binding]; other site 1064539006889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539006890 Coenzyme A binding pocket [chemical binding]; other site 1064539006891 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1064539006892 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1064539006893 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 1064539006894 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1064539006895 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1064539006896 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1064539006897 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1064539006898 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1064539006899 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1064539006900 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1064539006901 NifU-like domain; Region: NifU; pfam01106 1064539006902 Nif-specific regulatory protein; Region: nifA; TIGR01817 1064539006903 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1064539006904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539006905 Walker A motif; other site 1064539006906 ATP binding site [chemical binding]; other site 1064539006907 Walker B motif; other site 1064539006908 arginine finger; other site 1064539006909 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539006910 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064539006911 Zn2+ binding site [ion binding]; other site 1064539006912 Mg2+ binding site [ion binding]; other site 1064539006913 Hemerythrin; Region: Hemerythrin; cd12107 1064539006914 Fe binding site [ion binding]; other site 1064539006915 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064539006916 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1064539006917 dimer interface [polypeptide binding]; other site 1064539006918 active site 1064539006919 metal binding site [ion binding]; metal-binding site 1064539006920 glutathione binding site [chemical binding]; other site 1064539006921 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 1064539006922 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 1064539006923 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 1064539006924 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1064539006925 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1064539006926 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1064539006927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539006928 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1064539006929 Walker A/P-loop; other site 1064539006930 ATP binding site [chemical binding]; other site 1064539006931 Q-loop/lid; other site 1064539006932 ABC transporter signature motif; other site 1064539006933 Walker B; other site 1064539006934 D-loop; other site 1064539006935 H-loop/switch region; other site 1064539006936 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1064539006937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539006938 dimer interface [polypeptide binding]; other site 1064539006939 conserved gate region; other site 1064539006940 ABC-ATPase subunit interface; other site 1064539006941 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539006942 PAS fold; Region: PAS_3; pfam08447 1064539006943 putative active site [active] 1064539006944 heme pocket [chemical binding]; other site 1064539006945 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539006946 dimer interface [polypeptide binding]; other site 1064539006947 putative CheW interface [polypeptide binding]; other site 1064539006948 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 1064539006949 Domain of unknown function (DUF364); Region: DUF364; pfam04016 1064539006950 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1064539006951 Winged helix-turn helix; Region: HTH_29; pfam13551 1064539006952 Integrase core domain; Region: rve; pfam00665 1064539006953 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1064539006954 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1064539006955 metal ion-dependent adhesion site (MIDAS); other site 1064539006956 MoxR-like ATPases [General function prediction only]; Region: COG0714 1064539006957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539006958 Walker A motif; other site 1064539006959 ATP binding site [chemical binding]; other site 1064539006960 Walker B motif; other site 1064539006961 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1064539006962 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1064539006963 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1064539006964 D-pathway; other site 1064539006965 K-pathway; other site 1064539006966 Binuclear center (active site) [active] 1064539006967 Putative proton exit pathway; other site 1064539006968 Cytochrome c; Region: Cytochrom_C; pfam00034 1064539006969 Predicted transcriptional regulators [Transcription]; Region: COG1378 1064539006970 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064539006971 putative DNA binding site [nucleotide binding]; other site 1064539006972 putative Zn2+ binding site [ion binding]; other site 1064539006973 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539006974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539006975 dimer interface [polypeptide binding]; other site 1064539006976 conserved gate region; other site 1064539006977 putative PBP binding loops; other site 1064539006978 ABC-ATPase subunit interface; other site 1064539006979 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539006980 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539006981 Walker A/P-loop; other site 1064539006982 ATP binding site [chemical binding]; other site 1064539006983 Q-loop/lid; other site 1064539006984 ABC transporter signature motif; other site 1064539006985 Walker B; other site 1064539006986 D-loop; other site 1064539006987 H-loop/switch region; other site 1064539006988 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1064539006989 NMT1/THI5 like; Region: NMT1; pfam09084 1064539006990 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1064539006991 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1064539006992 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1064539006993 putative active site [active] 1064539006994 catalytic triad [active] 1064539006995 putative dimer interface [polypeptide binding]; other site 1064539006996 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1064539006997 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 1064539006998 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1064539006999 intersubunit interface [polypeptide binding]; other site 1064539007000 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1064539007001 putative PBP binding regions; other site 1064539007002 ABC-ATPase subunit interface; other site 1064539007003 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1064539007004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539007005 Walker A/P-loop; other site 1064539007006 ATP binding site [chemical binding]; other site 1064539007007 Q-loop/lid; other site 1064539007008 ABC transporter signature motif; other site 1064539007009 Walker B; other site 1064539007010 D-loop; other site 1064539007011 H-loop/switch region; other site 1064539007012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539007013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539007014 active site 1064539007015 phosphorylation site [posttranslational modification] 1064539007016 intermolecular recognition site; other site 1064539007017 dimerization interface [polypeptide binding]; other site 1064539007018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539007019 DNA binding site [nucleotide binding] 1064539007020 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor 1064539007021 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor 1064539007022 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 1064539007023 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1064539007024 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539007025 N-terminal plug; other site 1064539007026 ligand-binding site [chemical binding]; other site 1064539007027 Helix-turn-helix domain; Region: HTH_36; pfam13730 1064539007028 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1064539007029 ParB-like nuclease domain; Region: ParB; smart00470 1064539007030 Helix-turn-helix; Region: HTH_3; pfam01381 1064539007031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539007032 non-specific DNA binding site [nucleotide binding]; other site 1064539007033 salt bridge; other site 1064539007034 sequence-specific DNA binding site [nucleotide binding]; other site 1064539007035 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539007036 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1064539007037 P-loop; other site 1064539007038 Magnesium ion binding site [ion binding]; other site 1064539007039 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539007040 Magnesium ion binding site [ion binding]; other site 1064539007041 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064539007042 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1064539007043 peptide binding site [polypeptide binding]; other site 1064539007044 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1064539007045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539007046 dimer interface [polypeptide binding]; other site 1064539007047 phosphorylation site [posttranslational modification] 1064539007048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539007049 ATP binding site [chemical binding]; other site 1064539007050 Mg2+ binding site [ion binding]; other site 1064539007051 G-X-G motif; other site 1064539007052 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539007053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539007054 active site 1064539007055 phosphorylation site [posttranslational modification] 1064539007056 intermolecular recognition site; other site 1064539007057 dimerization interface [polypeptide binding]; other site 1064539007058 Hpt domain; Region: Hpt; pfam01627 1064539007059 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539007060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539007061 active site 1064539007062 phosphorylation site [posttranslational modification] 1064539007063 intermolecular recognition site; other site 1064539007064 dimerization interface [polypeptide binding]; other site 1064539007065 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1064539007066 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1064539007067 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1064539007068 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1064539007069 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539007070 N-terminal plug; other site 1064539007071 ligand-binding site [chemical binding]; other site 1064539007072 enterobactin exporter EntS; Provisional; Region: PRK10489 1064539007073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539007074 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539007075 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539007076 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539007077 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1064539007078 isochorismate synthase DhbC; Validated; Region: PRK06923 1064539007079 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1064539007080 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1064539007081 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1064539007082 acyl-activating enzyme (AAE) consensus motif; other site 1064539007083 active site 1064539007084 AMP binding site [chemical binding]; other site 1064539007085 substrate binding site [chemical binding]; other site 1064539007086 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1064539007087 Isochorismatase family; Region: Isochorismatase; pfam00857 1064539007088 catalytic triad [active] 1064539007089 conserved cis-peptide bond; other site 1064539007090 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1064539007091 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1064539007092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539007093 NAD(P) binding site [chemical binding]; other site 1064539007094 active site 1064539007095 MbtH-like protein; Region: MbtH; pfam03621 1064539007096 potential frameshift: common BLAST hit: gi|271501333|ref|YP_003334358.1| amino acid adenylation domain-containing protein 1064539007097 Condensation domain; Region: Condensation; pfam00668 1064539007098 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1064539007099 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1064539007100 acyl-activating enzyme (AAE) consensus motif; other site 1064539007101 AMP binding site [chemical binding]; other site 1064539007102 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1064539007103 Condensation domain; Region: Condensation; pfam00668 1064539007104 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1064539007105 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1064539007106 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1064539007107 acyl-activating enzyme (AAE) consensus motif; other site 1064539007108 AMP binding site [chemical binding]; other site 1064539007109 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1064539007110 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1064539007111 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1064539007112 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1064539007113 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1064539007114 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1064539007115 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539007116 Transposase domain (DUF772); Region: DUF772; pfam05598 1064539007117 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1064539007118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539007119 dimer interface [polypeptide binding]; other site 1064539007120 conserved gate region; other site 1064539007121 putative PBP binding loops; other site 1064539007122 ABC-ATPase subunit interface; other site 1064539007123 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1064539007124 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064539007125 Walker A/P-loop; other site 1064539007126 ATP binding site [chemical binding]; other site 1064539007127 Q-loop/lid; other site 1064539007128 ABC transporter signature motif; other site 1064539007129 Walker B; other site 1064539007130 D-loop; other site 1064539007131 H-loop/switch region; other site 1064539007132 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539007133 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539007134 substrate binding pocket [chemical binding]; other site 1064539007135 membrane-bound complex binding site; other site 1064539007136 hinge residues; other site 1064539007137 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1064539007138 active site 1064539007139 metal binding site [ion binding]; metal-binding site 1064539007140 allantoate amidohydrolase; Reviewed; Region: PRK12893 1064539007141 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1064539007142 active site 1064539007143 metal binding site [ion binding]; metal-binding site 1064539007144 dimer interface [polypeptide binding]; other site 1064539007145 dihydroorotase; Provisional; Region: PRK09237 1064539007146 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1064539007147 active site 1064539007148 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1064539007149 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1064539007150 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1064539007151 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1064539007152 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539007153 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1064539007154 ligand binding site [chemical binding]; other site 1064539007155 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539007156 TM-ABC transporter signature motif; other site 1064539007157 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539007158 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539007159 TM-ABC transporter signature motif; other site 1064539007160 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539007161 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539007162 Walker A/P-loop; other site 1064539007163 ATP binding site [chemical binding]; other site 1064539007164 Q-loop/lid; other site 1064539007165 ABC transporter signature motif; other site 1064539007166 Walker B; other site 1064539007167 D-loop; other site 1064539007168 H-loop/switch region; other site 1064539007169 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539007170 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539007171 Walker A/P-loop; other site 1064539007172 ATP binding site [chemical binding]; other site 1064539007173 Q-loop/lid; other site 1064539007174 ABC transporter signature motif; other site 1064539007175 Walker B; other site 1064539007176 D-loop; other site 1064539007177 H-loop/switch region; other site 1064539007178 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1064539007179 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1064539007180 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1064539007181 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1064539007182 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1064539007183 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064539007184 catalytic loop [active] 1064539007185 iron binding site [ion binding]; other site 1064539007186 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1064539007187 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1064539007188 putative hydrophobic ligand binding site [chemical binding]; other site 1064539007189 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539007190 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539007191 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1064539007192 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064539007193 MarR family; Region: MarR; pfam01047 1064539007194 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1064539007195 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 1064539007196 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1064539007197 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1064539007198 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1064539007199 Ligand binding site [chemical binding]; other site 1064539007200 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1064539007201 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1064539007202 FAD binding domain; Region: FAD_binding_4; pfam01565 1064539007203 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1064539007204 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1064539007205 NAD(P) binding site [chemical binding]; other site 1064539007206 catalytic residues [active] 1064539007207 Evidence 2b : Function of strongly homologous gene; PubMedId : 10736170; Product type e : enzyme 1064539007208 Evidence 2b : Function of strongly homologous gene; PubMedId : 10736170; Product type e : enzyme 1064539007209 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1064539007210 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1064539007211 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 1064539007212 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1064539007213 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1064539007214 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1064539007215 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1064539007216 TPP-binding site [chemical binding]; other site 1064539007217 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1064539007218 dimer interface [polypeptide binding]; other site 1064539007219 PYR/PP interface [polypeptide binding]; other site 1064539007220 TPP binding site [chemical binding]; other site 1064539007221 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539007222 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064539007223 active site 1064539007224 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539007225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539007226 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1064539007227 putative dimerization interface [polypeptide binding]; other site 1064539007228 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1064539007229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539007230 NAD(P) binding site [chemical binding]; other site 1064539007231 active site 1064539007232 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 1064539007233 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064539007234 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1064539007235 Subunit I/III interface [polypeptide binding]; other site 1064539007236 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1064539007237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539007238 ATP-grasp domain; Region: ATP-grasp; pfam02222 1064539007239 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 1064539007240 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1064539007241 putative metal binding site [ion binding]; other site 1064539007242 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1064539007243 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064539007244 ABC-ATPase subunit interface; other site 1064539007245 dimer interface [polypeptide binding]; other site 1064539007246 putative PBP binding regions; other site 1064539007247 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1064539007248 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1064539007249 Walker A/P-loop; other site 1064539007250 ATP binding site [chemical binding]; other site 1064539007251 Q-loop/lid; other site 1064539007252 ABC transporter signature motif; other site 1064539007253 Walker B; other site 1064539007254 D-loop; other site 1064539007255 H-loop/switch region; other site 1064539007256 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1064539007257 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1064539007258 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1064539007259 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1064539007260 Moco binding site; other site 1064539007261 metal coordination site [ion binding]; other site 1064539007262 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1064539007263 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064539007264 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1064539007265 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1064539007266 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1064539007267 active site 1064539007268 intersubunit interface [polypeptide binding]; other site 1064539007269 catalytic residue [active] 1064539007270 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539007271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539007272 DNA-binding site [nucleotide binding]; DNA binding site 1064539007273 FCD domain; Region: FCD; pfam07729 1064539007274 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064539007275 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1064539007276 substrate binding site [chemical binding]; other site 1064539007277 ATP binding site [chemical binding]; other site 1064539007278 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539007279 EamA-like transporter family; Region: EamA; pfam00892 1064539007280 EamA-like transporter family; Region: EamA; pfam00892 1064539007281 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1064539007282 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539007283 DNA binding site [nucleotide binding] 1064539007284 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 1064539007285 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1064539007286 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1064539007287 Flagellar protein FlaF; Region: FlaF; pfam07309 1064539007288 Flagellar protein FlbT; Region: FlbT; pfam07378 1064539007289 FlaG protein; Region: FlaG; cl00591 1064539007290 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1064539007291 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 1064539007292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539007293 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1064539007294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539007295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539007296 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1064539007297 putative effector binding pocket; other site 1064539007298 dimerization interface [polypeptide binding]; other site 1064539007299 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 1064539007300 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1064539007301 Walker A motif/ATP binding site; other site 1064539007302 Walker B motif; other site 1064539007303 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 1064539007304 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 1064539007305 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1064539007306 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064539007307 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1064539007308 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 1064539007309 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539007310 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539007311 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1064539007312 FHIPEP family; Region: FHIPEP; pfam00771 1064539007313 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1064539007314 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1064539007315 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1064539007316 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1064539007317 AsnC family; Region: AsnC_trans_reg; pfam01037 1064539007318 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1064539007319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539007320 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1064539007321 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1064539007322 PYR/PP interface [polypeptide binding]; other site 1064539007323 dimer interface [polypeptide binding]; other site 1064539007324 tetramer interface [polypeptide binding]; other site 1064539007325 TPP binding site [chemical binding]; other site 1064539007326 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064539007327 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1064539007328 TPP-binding site [chemical binding]; other site 1064539007329 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1064539007330 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1064539007331 FMN-binding pocket [chemical binding]; other site 1064539007332 flavin binding motif; other site 1064539007333 phosphate binding motif [ion binding]; other site 1064539007334 beta-alpha-beta structure motif; other site 1064539007335 NAD binding pocket [chemical binding]; other site 1064539007336 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064539007337 catalytic loop [active] 1064539007338 iron binding site [ion binding]; other site 1064539007339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539007340 PAS domain; Region: PAS_9; pfam13426 1064539007341 putative active site [active] 1064539007342 heme pocket [chemical binding]; other site 1064539007343 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 1064539007344 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1064539007345 C-terminal peptidase (prc); Region: prc; TIGR00225 1064539007346 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1064539007347 protein binding site [polypeptide binding]; other site 1064539007348 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1064539007349 Catalytic dyad [active] 1064539007350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539007351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539007352 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1064539007353 putative effector binding pocket; other site 1064539007354 dimerization interface [polypeptide binding]; other site 1064539007355 short chain dehydrogenase; Provisional; Region: PRK06500 1064539007356 classical (c) SDRs; Region: SDR_c; cd05233 1064539007357 NAD(P) binding site [chemical binding]; other site 1064539007358 active site 1064539007359 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1064539007360 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1064539007361 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1064539007362 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1064539007363 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 1064539007364 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064539007365 catalytic loop [active] 1064539007366 iron binding site [ion binding]; other site 1064539007367 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1064539007368 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539007369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539007370 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1064539007371 putative effector binding pocket; other site 1064539007372 putative dimerization interface [polypeptide binding]; other site 1064539007373 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1064539007374 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1064539007375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539007376 PAS domain; Region: PAS_9; pfam13426 1064539007377 putative active site [active] 1064539007378 heme pocket [chemical binding]; other site 1064539007379 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539007380 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539007381 metal binding site [ion binding]; metal-binding site 1064539007382 active site 1064539007383 I-site; other site 1064539007384 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539007385 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1064539007386 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1064539007387 putative active site [active] 1064539007388 Rod binding protein; Region: Rod-binding; pfam10135 1064539007389 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1064539007390 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1064539007391 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 1064539007392 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1064539007393 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1064539007394 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 1064539007395 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064539007396 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1064539007397 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1064539007398 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1064539007399 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064539007400 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539007401 DNA-binding site [nucleotide binding]; DNA binding site 1064539007402 RNA-binding motif; other site 1064539007403 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539007404 DNA-binding site [nucleotide binding]; DNA binding site 1064539007405 RNA-binding motif; other site 1064539007406 Helix-turn-helix domain; Region: HTH_17; cl17695 1064539007407 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 1064539007408 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539007409 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1064539007410 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1064539007411 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539007412 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1064539007413 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539007414 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539007415 dimerization interface [polypeptide binding]; other site 1064539007416 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539007417 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure 1064539007418 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : putative structure 1064539007419 DctM-like transporters; Region: DctM; pfam06808 1064539007420 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1064539007421 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1064539007422 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539007423 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539007424 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539007425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539007426 DNA-binding site [nucleotide binding]; DNA binding site 1064539007427 FCD domain; Region: FCD; pfam07729 1064539007428 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539007429 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1064539007430 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1064539007431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539007432 FeS/SAM binding site; other site 1064539007433 pyruvate kinase; Provisional; Region: PRK06247 1064539007434 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1064539007435 domain interfaces; other site 1064539007436 active site 1064539007437 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1064539007438 GAF domain; Region: GAF; pfam01590 1064539007439 Phytochrome region; Region: PHY; pfam00360 1064539007440 HWE histidine kinase; Region: HWE_HK; pfam07536 1064539007441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539007442 active site 1064539007443 phosphorylation site [posttranslational modification] 1064539007444 intermolecular recognition site; other site 1064539007445 dimerization interface [polypeptide binding]; other site 1064539007446 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539007447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539007448 putative active site [active] 1064539007449 heme pocket [chemical binding]; other site 1064539007450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539007451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539007452 dimer interface [polypeptide binding]; other site 1064539007453 phosphorylation site [posttranslational modification] 1064539007454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539007455 ATP binding site [chemical binding]; other site 1064539007456 Mg2+ binding site [ion binding]; other site 1064539007457 G-X-G motif; other site 1064539007458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539007459 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539007460 active site 1064539007461 phosphorylation site [posttranslational modification] 1064539007462 intermolecular recognition site; other site 1064539007463 dimerization interface [polypeptide binding]; other site 1064539007464 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539007465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539007466 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1064539007467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539007468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539007469 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1064539007470 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1064539007471 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539007472 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539007473 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1064539007474 Protein export membrane protein; Region: SecD_SecF; cl14618 1064539007475 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1064539007476 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1064539007477 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1064539007478 putative active site [active] 1064539007479 Pyruvate formate lyase 1; Region: PFL1; cd01678 1064539007480 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1064539007481 coenzyme A binding site [chemical binding]; other site 1064539007482 active site 1064539007483 catalytic residues [active] 1064539007484 glycine loop; other site 1064539007485 enolase; Provisional; Region: eno; PRK00077 1064539007486 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1064539007487 dimer interface [polypeptide binding]; other site 1064539007488 metal binding site [ion binding]; metal-binding site 1064539007489 substrate binding pocket [chemical binding]; other site 1064539007490 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 1064539007491 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1064539007492 dimer interaction site [polypeptide binding]; other site 1064539007493 substrate-binding tunnel; other site 1064539007494 active site 1064539007495 catalytic site [active] 1064539007496 substrate binding site [chemical binding]; other site 1064539007497 phosphate acetyltransferase; Provisional; Region: PRK11890 1064539007498 Acetokinase family; Region: Acetate_kinase; cl17229 1064539007499 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1064539007500 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1064539007501 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1064539007502 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1064539007503 NADP binding site [chemical binding]; other site 1064539007504 homodimer interface [polypeptide binding]; other site 1064539007505 active site 1064539007506 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1064539007507 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539007508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539007509 DNA-binding site [nucleotide binding]; DNA binding site 1064539007510 FCD domain; Region: FCD; pfam07729 1064539007511 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1064539007512 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1064539007513 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1064539007514 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1064539007515 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1064539007516 Protein of unknown function DUF86; Region: DUF86; cl01031 1064539007517 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1064539007518 active site 1064539007519 NTP binding site [chemical binding]; other site 1064539007520 metal binding triad [ion binding]; metal-binding site 1064539007521 antibiotic binding site [chemical binding]; other site 1064539007522 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1064539007523 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1064539007524 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1064539007525 TIGR02646 family protein; Region: TIGR02646 1064539007526 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 1064539007527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539007528 Walker A/P-loop; other site 1064539007529 ATP binding site [chemical binding]; other site 1064539007530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064539007531 ATP binding site [chemical binding]; other site 1064539007532 putative Mg++ binding site [ion binding]; other site 1064539007533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539007534 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1064539007535 nucleotide binding region [chemical binding]; other site 1064539007536 ATP-binding site [chemical binding]; other site 1064539007537 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1064539007538 WYL domain; Region: WYL; pfam13280 1064539007539 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1064539007540 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1064539007541 catalytic residues [active] 1064539007542 catalytic nucleophile [active] 1064539007543 Presynaptic Site I dimer interface [polypeptide binding]; other site 1064539007544 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1064539007545 Synaptic Flat tetramer interface [polypeptide binding]; other site 1064539007546 Synaptic Site I dimer interface [polypeptide binding]; other site 1064539007547 DNA binding site [nucleotide binding] 1064539007548 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1064539007549 DNA-binding interface [nucleotide binding]; DNA binding site 1064539007550 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1064539007551 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1064539007552 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1064539007553 Domain of unknown function (DUF927); Region: DUF927; pfam06048 1064539007554 CHC2 zinc finger; Region: zf-CHC2; cl17510 1064539007555 Helix-turn-helix domain; Region: HTH_17; pfam12728 1064539007556 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1064539007557 active site 1064539007558 Int/Topo IB signature motif; other site 1064539007559 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1064539007560 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064539007561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539007562 dimerization interface [polypeptide binding]; other site 1064539007563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1064539007564 phosphorylation site [posttranslational modification] 1064539007565 dimer interface [polypeptide binding]; other site 1064539007566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539007567 ATP binding site [chemical binding]; other site 1064539007568 Mg2+ binding site [ion binding]; other site 1064539007569 G-X-G motif; other site 1064539007570 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1064539007571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539007572 active site 1064539007573 phosphorylation site [posttranslational modification] 1064539007574 intermolecular recognition site; other site 1064539007575 dimerization interface [polypeptide binding]; other site 1064539007576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539007577 Walker A motif; other site 1064539007578 ATP binding site [chemical binding]; other site 1064539007579 Walker B motif; other site 1064539007580 arginine finger; other site 1064539007581 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539007582 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1064539007583 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539007584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539007585 homodimer interface [polypeptide binding]; other site 1064539007586 catalytic residue [active] 1064539007587 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1064539007588 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1064539007589 TrkA-C domain; Region: TrkA_C; pfam02080 1064539007590 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1064539007591 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064539007592 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1064539007593 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1064539007594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539007595 dimer interface [polypeptide binding]; other site 1064539007596 conserved gate region; other site 1064539007597 putative PBP binding loops; other site 1064539007598 ABC-ATPase subunit interface; other site 1064539007599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539007600 dimer interface [polypeptide binding]; other site 1064539007601 conserved gate region; other site 1064539007602 putative PBP binding loops; other site 1064539007603 ABC-ATPase subunit interface; other site 1064539007604 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1064539007605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539007606 Walker A/P-loop; other site 1064539007607 ATP binding site [chemical binding]; other site 1064539007608 Q-loop/lid; other site 1064539007609 ABC transporter signature motif; other site 1064539007610 Walker B; other site 1064539007611 D-loop; other site 1064539007612 H-loop/switch region; other site 1064539007613 TOBE domain; Region: TOBE_2; pfam08402 1064539007614 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1064539007615 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1064539007616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539007617 motif II; other site 1064539007618 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064539007619 catalytic core [active] 1064539007620 acetylornithine deacetylase; Provisional; Region: PRK07522 1064539007621 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1064539007622 metal binding site [ion binding]; metal-binding site 1064539007623 putative dimer interface [polypeptide binding]; other site 1064539007624 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 1064539007625 agmatinase; Region: agmatinase; TIGR01230 1064539007626 oligomer interface [polypeptide binding]; other site 1064539007627 active site 1064539007628 Mn binding site [ion binding]; other site 1064539007629 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1064539007630 homotrimer interaction site [polypeptide binding]; other site 1064539007631 putative active site [active] 1064539007632 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539007633 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1064539007634 Walker A/P-loop; other site 1064539007635 ATP binding site [chemical binding]; other site 1064539007636 Q-loop/lid; other site 1064539007637 ABC transporter signature motif; other site 1064539007638 Walker B; other site 1064539007639 D-loop; other site 1064539007640 H-loop/switch region; other site 1064539007641 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539007642 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539007643 Walker A/P-loop; other site 1064539007644 ATP binding site [chemical binding]; other site 1064539007645 Q-loop/lid; other site 1064539007646 ABC transporter signature motif; other site 1064539007647 Walker B; other site 1064539007648 D-loop; other site 1064539007649 H-loop/switch region; other site 1064539007650 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539007651 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1064539007652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539007653 dimer interface [polypeptide binding]; other site 1064539007654 conserved gate region; other site 1064539007655 putative PBP binding loops; other site 1064539007656 ABC-ATPase subunit interface; other site 1064539007657 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539007658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539007659 dimer interface [polypeptide binding]; other site 1064539007660 conserved gate region; other site 1064539007661 putative PBP binding loops; other site 1064539007662 ABC-ATPase subunit interface; other site 1064539007663 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064539007664 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1064539007665 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1064539007666 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539007667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539007668 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064539007669 dimerization interface [polypeptide binding]; other site 1064539007670 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1064539007671 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1064539007672 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1064539007673 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1064539007674 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1064539007675 dimerization domain swap beta strand [polypeptide binding]; other site 1064539007676 regulatory protein interface [polypeptide binding]; other site 1064539007677 active site 1064539007678 regulatory phosphorylation site [posttranslational modification]; other site 1064539007679 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1064539007680 active pocket/dimerization site; other site 1064539007681 active site 1064539007682 phosphorylation site [posttranslational modification] 1064539007683 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1064539007684 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1064539007685 Hpr binding site; other site 1064539007686 active site 1064539007687 homohexamer subunit interaction site [polypeptide binding]; other site 1064539007688 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 1064539007689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539007690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539007691 dimerization interface [polypeptide binding]; other site 1064539007692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539007693 dimer interface [polypeptide binding]; other site 1064539007694 phosphorylation site [posttranslational modification] 1064539007695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539007696 ATP binding site [chemical binding]; other site 1064539007697 Mg2+ binding site [ion binding]; other site 1064539007698 G-X-G motif; other site 1064539007699 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539007700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539007701 active site 1064539007702 phosphorylation site [posttranslational modification] 1064539007703 intermolecular recognition site; other site 1064539007704 dimerization interface [polypeptide binding]; other site 1064539007705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539007706 DNA binding site [nucleotide binding] 1064539007707 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1064539007708 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1064539007709 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1064539007710 active site 1064539007711 substrate-binding site [chemical binding]; other site 1064539007712 metal-binding site [ion binding] 1064539007713 GTP binding site [chemical binding]; other site 1064539007714 flagellar motor protein MotA; Validated; Region: PRK09110 1064539007715 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1064539007716 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1064539007717 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1064539007718 Peptidase family M23; Region: Peptidase_M23; pfam01551 1064539007719 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539007720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1064539007721 putative active site [active] 1064539007722 heme pocket [chemical binding]; other site 1064539007723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539007724 dimer interface [polypeptide binding]; other site 1064539007725 phosphorylation site [posttranslational modification] 1064539007726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539007727 ATP binding site [chemical binding]; other site 1064539007728 Mg2+ binding site [ion binding]; other site 1064539007729 G-X-G motif; other site 1064539007730 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539007731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539007732 active site 1064539007733 phosphorylation site [posttranslational modification] 1064539007734 intermolecular recognition site; other site 1064539007735 dimerization interface [polypeptide binding]; other site 1064539007736 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1064539007737 DNA binding site [nucleotide binding] 1064539007738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539007739 TPR motif; other site 1064539007740 binding surface 1064539007741 TPR repeat; Region: TPR_11; pfam13414 1064539007742 Family description; Region: VCBS; pfam13517 1064539007743 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539007744 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539007745 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539007746 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539007747 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1064539007748 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1064539007749 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1064539007750 potential frameshift: common BLAST hit: gi|186681177|ref|YP_001864373.1| group 1 glycosyl transferase 1064539007751 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539007752 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1064539007753 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1064539007754 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 1064539007755 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1064539007756 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1064539007757 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1064539007758 putative acyltransferase; Provisional; Region: PRK05790 1064539007759 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1064539007760 dimer interface [polypeptide binding]; other site 1064539007761 active site 1064539007762 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1064539007763 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1064539007764 NAD(P) binding site [chemical binding]; other site 1064539007765 homotetramer interface [polypeptide binding]; other site 1064539007766 homodimer interface [polypeptide binding]; other site 1064539007767 active site 1064539007768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539007769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539007770 putative substrate translocation pore; other site 1064539007771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539007772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539007773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064539007774 dimerization interface [polypeptide binding]; other site 1064539007775 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 1064539007776 nudix motif; other site 1064539007777 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539007778 GTP-binding protein YchF; Reviewed; Region: PRK09601 1064539007779 YchF GTPase; Region: YchF; cd01900 1064539007780 G1 box; other site 1064539007781 GTP/Mg2+ binding site [chemical binding]; other site 1064539007782 Switch I region; other site 1064539007783 G2 box; other site 1064539007784 Switch II region; other site 1064539007785 G3 box; other site 1064539007786 G4 box; other site 1064539007787 G5 box; other site 1064539007788 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1064539007789 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1064539007790 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1064539007791 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1064539007792 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1064539007793 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539007794 PAS domain; Region: PAS_8; pfam13188 1064539007795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539007796 dimer interface [polypeptide binding]; other site 1064539007797 phosphorylation site [posttranslational modification] 1064539007798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539007799 ATP binding site [chemical binding]; other site 1064539007800 Mg2+ binding site [ion binding]; other site 1064539007801 G-X-G motif; other site 1064539007802 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539007803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539007804 active site 1064539007805 phosphorylation site [posttranslational modification] 1064539007806 intermolecular recognition site; other site 1064539007807 dimerization interface [polypeptide binding]; other site 1064539007808 CheB methylesterase; Region: CheB_methylest; pfam01339 1064539007809 CheB methylesterase; Region: CheB_methylest; pfam01339 1064539007810 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1064539007811 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1064539007812 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1064539007813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539007814 PAS domain; Region: PAS_9; pfam13426 1064539007815 putative active site [active] 1064539007816 heme pocket [chemical binding]; other site 1064539007817 PAS fold; Region: PAS_4; pfam08448 1064539007818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539007819 putative active site [active] 1064539007820 heme pocket [chemical binding]; other site 1064539007821 PAS domain; Region: PAS_9; pfam13426 1064539007822 DNA polymerase I; Provisional; Region: PRK05755 1064539007823 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1064539007824 active site 1064539007825 metal binding site 1 [ion binding]; metal-binding site 1064539007826 putative 5' ssDNA interaction site; other site 1064539007827 metal binding site 3; metal-binding site 1064539007828 metal binding site 2 [ion binding]; metal-binding site 1064539007829 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1064539007830 putative DNA binding site [nucleotide binding]; other site 1064539007831 putative metal binding site [ion binding]; other site 1064539007832 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1064539007833 active site 1064539007834 catalytic site [active] 1064539007835 substrate binding site [chemical binding]; other site 1064539007836 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1064539007837 active site 1064539007838 DNA binding site [nucleotide binding] 1064539007839 catalytic site [active] 1064539007840 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1064539007841 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1064539007842 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1064539007843 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1064539007844 Walker A/P-loop; other site 1064539007845 ATP binding site [chemical binding]; other site 1064539007846 Q-loop/lid; other site 1064539007847 ABC transporter signature motif; other site 1064539007848 Walker B; other site 1064539007849 D-loop; other site 1064539007850 H-loop/switch region; other site 1064539007851 Zinc-finger domain; Region: zf-CHCC; cl01821 1064539007852 PAS domain S-box; Region: sensory_box; TIGR00229 1064539007853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539007854 putative active site [active] 1064539007855 heme pocket [chemical binding]; other site 1064539007856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539007857 PAS domain; Region: PAS_9; pfam13426 1064539007858 putative active site [active] 1064539007859 heme pocket [chemical binding]; other site 1064539007860 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539007861 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539007862 metal binding site [ion binding]; metal-binding site 1064539007863 active site 1064539007864 I-site; other site 1064539007865 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539007866 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1064539007867 Cytochrome c; Region: Cytochrom_C; cl11414 1064539007868 Cytochrome c; Region: Cytochrom_C; cl11414 1064539007869 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1064539007870 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1064539007871 Cytochrome c; Region: Cytochrom_C; pfam00034 1064539007872 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1064539007873 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1064539007874 D-pathway; other site 1064539007875 Putative ubiquinol binding site [chemical binding]; other site 1064539007876 Low-spin heme (heme b) binding site [chemical binding]; other site 1064539007877 Putative water exit pathway; other site 1064539007878 Binuclear center (heme o3/CuB) [ion binding]; other site 1064539007879 K-pathway; other site 1064539007880 Putative proton exit pathway; other site 1064539007881 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1064539007882 Subunit I/III interface [polypeptide binding]; other site 1064539007883 Predicted integral membrane protein [Function unknown]; Region: COG5473 1064539007884 Acylphosphatase; Region: Acylphosphatase; pfam00708 1064539007885 xanthine permease; Region: pbuX; TIGR03173 1064539007886 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539007887 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539007888 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1064539007889 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1064539007890 putative active site [active] 1064539007891 catalytic triad [active] 1064539007892 putative dimer interface [polypeptide binding]; other site 1064539007893 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1064539007894 agmatinase; Region: agmatinase; TIGR01230 1064539007895 oligomer interface [polypeptide binding]; other site 1064539007896 putative active site [active] 1064539007897 Mn binding site [ion binding]; other site 1064539007898 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064539007899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539007900 dimer interface [polypeptide binding]; other site 1064539007901 conserved gate region; other site 1064539007902 putative PBP binding loops; other site 1064539007903 ABC-ATPase subunit interface; other site 1064539007904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539007905 putative PBP binding loops; other site 1064539007906 ABC-ATPase subunit interface; other site 1064539007907 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1064539007908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539007909 Walker A/P-loop; other site 1064539007910 ATP binding site [chemical binding]; other site 1064539007911 Q-loop/lid; other site 1064539007912 ABC transporter signature motif; other site 1064539007913 Walker B; other site 1064539007914 D-loop; other site 1064539007915 H-loop/switch region; other site 1064539007916 TOBE domain; Region: TOBE_2; pfam08402 1064539007917 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1064539007918 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539007919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539007920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539007921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064539007922 dimerization interface [polypeptide binding]; other site 1064539007923 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1064539007924 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1064539007925 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1064539007926 trimer interface [polypeptide binding]; other site 1064539007927 active site 1064539007928 substrate binding site [chemical binding]; other site 1064539007929 CoA binding site [chemical binding]; other site 1064539007930 Transglycosylase; Region: Transgly; pfam00912 1064539007931 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1064539007932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539007933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539007934 DNA binding residues [nucleotide binding] 1064539007935 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1064539007936 FecR protein; Region: FecR; pfam04773 1064539007937 Secretin and TonB N terminus short domain; Region: STN; smart00965 1064539007938 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1064539007939 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1064539007940 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539007941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539007942 binding surface 1064539007943 TPR motif; other site 1064539007944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539007945 binding surface 1064539007946 TPR motif; other site 1064539007947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539007948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539007949 ATP binding site [chemical binding]; other site 1064539007950 Mg2+ binding site [ion binding]; other site 1064539007951 G-X-G motif; other site 1064539007952 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1064539007953 active site 1064539007954 P-loop; other site 1064539007955 phosphorylation site [posttranslational modification] 1064539007956 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1064539007957 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1064539007958 active site 1064539007959 P-loop; other site 1064539007960 phosphorylation site [posttranslational modification] 1064539007961 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1064539007962 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064539007963 active site 1064539007964 phosphorylation site [posttranslational modification] 1064539007965 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1064539007966 dimerization domain swap beta strand [polypeptide binding]; other site 1064539007967 regulatory protein interface [polypeptide binding]; other site 1064539007968 active site 1064539007969 regulatory phosphorylation site [posttranslational modification]; other site 1064539007970 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1064539007971 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1064539007972 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1064539007973 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1064539007974 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1064539007975 putative substrate binding site [chemical binding]; other site 1064539007976 putative ATP binding site [chemical binding]; other site 1064539007977 potential frameshift: common BLAST hit: gi|294678065|ref|YP_003578680.1| multiphosphoryl transfer protein 1064539007978 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1064539007979 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1064539007980 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539007981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539007982 active site 1064539007983 phosphorylation site [posttranslational modification] 1064539007984 intermolecular recognition site; other site 1064539007985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539007986 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539007987 putative active site [active] 1064539007988 heme pocket [chemical binding]; other site 1064539007989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539007990 putative active site [active] 1064539007991 heme pocket [chemical binding]; other site 1064539007992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539007993 PAS domain; Region: PAS_9; pfam13426 1064539007994 putative active site [active] 1064539007995 heme pocket [chemical binding]; other site 1064539007996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539007997 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539007998 dimer interface [polypeptide binding]; other site 1064539007999 phosphorylation site [posttranslational modification] 1064539008000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539008001 ATP binding site [chemical binding]; other site 1064539008002 Mg2+ binding site [ion binding]; other site 1064539008003 G-X-G motif; other site 1064539008004 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539008005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539008006 active site 1064539008007 phosphorylation site [posttranslational modification] 1064539008008 intermolecular recognition site; other site 1064539008009 dimerization interface [polypeptide binding]; other site 1064539008010 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539008011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539008012 active site 1064539008013 phosphorylation site [posttranslational modification] 1064539008014 intermolecular recognition site; other site 1064539008015 dimerization interface [polypeptide binding]; other site 1064539008016 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1064539008017 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1064539008018 Phytochrome region; Region: PHY; pfam00360 1064539008019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539008020 dimer interface [polypeptide binding]; other site 1064539008021 phosphorylation site [posttranslational modification] 1064539008022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539008023 ATP binding site [chemical binding]; other site 1064539008024 Mg2+ binding site [ion binding]; other site 1064539008025 G-X-G motif; other site 1064539008026 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539008027 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539008028 ligand binding site [chemical binding]; other site 1064539008029 flexible hinge region; other site 1064539008030 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1064539008031 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1064539008032 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1064539008033 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1064539008034 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1064539008035 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 1064539008036 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1064539008037 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1064539008038 active site 1064539008039 intersubunit interface [polypeptide binding]; other site 1064539008040 zinc binding site [ion binding]; other site 1064539008041 Na+ binding site [ion binding]; other site 1064539008042 potential frameshift: common BLAST hit: gi|374294413|ref|YP_005041438.1| putative L-arabinonolactonase 1064539008043 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1064539008044 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1064539008045 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1765093, 2016273, 2677392, 3889833, 6086598, 7490260,9927652; Product type e : enzyme 1064539008046 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1765093, 2016273, 2677392, 3889833, 6086598, 7490260,9927652; Product type e : enzyme 1064539008047 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1064539008048 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1064539008049 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539008050 DNA-binding site [nucleotide binding]; DNA binding site 1064539008051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539008052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539008053 homodimer interface [polypeptide binding]; other site 1064539008054 catalytic residue [active] 1064539008055 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1064539008056 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1064539008057 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1064539008058 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1064539008059 Ion channel; Region: Ion_trans_2; pfam07885 1064539008060 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1064539008061 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1064539008062 putative catalytic residue [active] 1064539008063 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539008064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539008065 active site 1064539008066 phosphorylation site [posttranslational modification] 1064539008067 intermolecular recognition site; other site 1064539008068 dimerization interface [polypeptide binding]; other site 1064539008069 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539008070 DNA binding site [nucleotide binding] 1064539008071 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1064539008072 homotrimer interaction site [polypeptide binding]; other site 1064539008073 putative active site [active] 1064539008074 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1064539008075 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1064539008076 NnrU protein; Region: NnrU; pfam07298 1064539008077 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1064539008078 CoenzymeA binding site [chemical binding]; other site 1064539008079 subunit interaction site [polypeptide binding]; other site 1064539008080 PHB binding site; other site 1064539008081 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1064539008082 ThiS interaction site; other site 1064539008083 putative active site [active] 1064539008084 tetramer interface [polypeptide binding]; other site 1064539008085 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1064539008086 thiS-thiF/thiG interaction site; other site 1064539008087 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064539008088 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1064539008089 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1064539008090 MgtE intracellular N domain; Region: MgtE_N; smart00924 1064539008091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1064539008092 Divalent cation transporter; Region: MgtE; pfam01769 1064539008093 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1064539008094 anti sigma factor interaction site; other site 1064539008095 regulatory phosphorylation site [posttranslational modification]; other site 1064539008096 lipoate-protein ligase B; Provisional; Region: PRK14341 1064539008097 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1064539008098 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1064539008099 NAD binding site [chemical binding]; other site 1064539008100 catalytic residues [active] 1064539008101 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1064539008102 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1064539008103 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539008104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539008105 dimer interface [polypeptide binding]; other site 1064539008106 conserved gate region; other site 1064539008107 putative PBP binding loops; other site 1064539008108 ABC-ATPase subunit interface; other site 1064539008109 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1064539008110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539008111 dimer interface [polypeptide binding]; other site 1064539008112 conserved gate region; other site 1064539008113 putative PBP binding loops; other site 1064539008114 ABC-ATPase subunit interface; other site 1064539008115 Evidence 2b : Function of strongly homologous gene; PubMedId : 7536291; Product type t : transporter 1064539008116 Evidence 2b : Function of strongly homologous gene; PubMedId : 7536291; Product type t : transporter 1064539008117 acetylornithine deacetylase; Provisional; Region: PRK07522 1064539008118 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1064539008119 metal binding site [ion binding]; metal-binding site 1064539008120 putative dimer interface [polypeptide binding]; other site 1064539008121 short chain dehydrogenase; Provisional; Region: PRK08278 1064539008122 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1064539008123 NAD(P) binding site [chemical binding]; other site 1064539008124 homodimer interface [polypeptide binding]; other site 1064539008125 active site 1064539008126 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1064539008127 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1064539008128 ligand binding site [chemical binding]; other site 1064539008129 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539008130 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539008131 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539008132 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539008133 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539008134 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539008135 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539008136 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539008137 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539008138 Isochorismatase family; Region: Isochorismatase; pfam00857 1064539008139 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1064539008140 catalytic triad [active] 1064539008141 conserved cis-peptide bond; other site 1064539008142 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1064539008143 active site 1064539008144 tetramer interface; other site 1064539008145 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1064539008146 HSP70 interaction site [polypeptide binding]; other site 1064539008147 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1064539008148 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1064539008149 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1064539008150 active site 1064539008151 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1064539008152 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539008153 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 1064539008154 GIY-YIG motif/motif A; other site 1064539008155 putative active site [active] 1064539008156 putative metal binding site [ion binding]; other site 1064539008157 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1064539008158 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1064539008159 substrate-cofactor binding pocket; other site 1064539008160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539008161 catalytic residue [active] 1064539008162 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1064539008163 potential frameshift: common BLAST hit: gi|311107550|ref|YP_003980403.1| dethiobiotin synthase 1064539008164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1064539008165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1064539008166 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1064539008167 AAA domain; Region: AAA_26; pfam13500 1064539008168 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064539008169 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1064539008170 inhibitor-cofactor binding pocket; inhibition site 1064539008171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539008172 catalytic residue [active] 1064539008173 biotin synthase; Region: bioB; TIGR00433 1064539008174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539008175 FeS/SAM binding site; other site 1064539008176 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1064539008177 Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028 1064539008178 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1064539008179 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1064539008180 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1064539008181 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1064539008182 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1064539008183 Beta-lactamase; Region: Beta-lactamase; pfam00144 1064539008184 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1064539008185 CheD chemotactic sensory transduction; Region: CheD; cl00810 1064539008186 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539008187 DNA-binding site [nucleotide binding]; DNA binding site 1064539008188 RNA-binding motif; other site 1064539008189 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539008190 DNA-binding site [nucleotide binding]; DNA binding site 1064539008191 RNA-binding motif; other site 1064539008192 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1064539008193 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1064539008194 acyl-activating enzyme (AAE) consensus motif; other site 1064539008195 putative AMP binding site [chemical binding]; other site 1064539008196 putative active site [active] 1064539008197 putative CoA binding site [chemical binding]; other site 1064539008198 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1064539008199 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1064539008200 NADP binding site [chemical binding]; other site 1064539008201 homopentamer interface [polypeptide binding]; other site 1064539008202 substrate binding site [chemical binding]; other site 1064539008203 active site 1064539008204 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1064539008205 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1064539008206 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1064539008207 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1064539008208 Hemerythrin; Region: Hemerythrin; cd12107 1064539008209 Fe binding site [ion binding]; other site 1064539008210 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1064539008211 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1064539008212 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064539008213 active site 1064539008214 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1064539008215 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1064539008216 5S rRNA interface [nucleotide binding]; other site 1064539008217 CTC domain interface [polypeptide binding]; other site 1064539008218 L16 interface [polypeptide binding]; other site 1064539008219 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1064539008220 putative active site [active] 1064539008221 catalytic residue [active] 1064539008222 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539008223 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1064539008224 TM-ABC transporter signature motif; other site 1064539008225 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539008226 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1064539008227 TM-ABC transporter signature motif; other site 1064539008228 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1064539008229 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1064539008230 Walker A/P-loop; other site 1064539008231 ATP binding site [chemical binding]; other site 1064539008232 Q-loop/lid; other site 1064539008233 ABC transporter signature motif; other site 1064539008234 Walker B; other site 1064539008235 D-loop; other site 1064539008236 H-loop/switch region; other site 1064539008237 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1064539008238 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1064539008239 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1064539008240 putative ligand binding site [chemical binding]; other site 1064539008241 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1064539008242 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1064539008243 dimer interface [polypeptide binding]; other site 1064539008244 NADP binding site [chemical binding]; other site 1064539008245 catalytic residues [active] 1064539008246 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1064539008247 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1064539008248 inhibitor site; inhibition site 1064539008249 active site 1064539008250 dimer interface [polypeptide binding]; other site 1064539008251 catalytic residue [active] 1064539008252 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1064539008253 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1064539008254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539008255 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1064539008256 putative dimerization interface [polypeptide binding]; other site 1064539008257 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1064539008258 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1064539008259 putative ligand binding site [chemical binding]; other site 1064539008260 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1064539008261 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1064539008262 Walker A/P-loop; other site 1064539008263 ATP binding site [chemical binding]; other site 1064539008264 Q-loop/lid; other site 1064539008265 ABC transporter signature motif; other site 1064539008266 Walker B; other site 1064539008267 D-loop; other site 1064539008268 H-loop/switch region; other site 1064539008269 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1064539008270 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539008271 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1064539008272 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1064539008273 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539008274 TM-ABC transporter signature motif; other site 1064539008275 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1064539008276 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064539008277 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 1064539008278 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1064539008279 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1064539008280 active site 1064539008281 catalytic residues [active] 1064539008282 altronate oxidoreductase; Provisional; Region: PRK03643 1064539008283 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1064539008284 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1064539008285 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1064539008286 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539008287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539008288 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1064539008289 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1064539008290 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1064539008291 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1064539008292 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1064539008293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539008294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539008295 Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_VIc; cl02795 1064539008296 Subunit VIc/II interface [polypeptide binding]; other site 1064539008297 Subunit VIc/Va interface [polypeptide binding]; other site 1064539008298 Subunit VIc/I interface [polypeptide binding]; other site 1064539008299 Subunit VIc/IV interface [polypeptide binding]; other site 1064539008300 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539008301 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539008302 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539008303 multidrug efflux protein; Reviewed; Region: PRK09579 1064539008304 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1064539008305 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1064539008306 NADP binding site [chemical binding]; other site 1064539008307 Predicted transcriptional regulators [Transcription]; Region: COG1733 1064539008308 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1064539008309 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1064539008310 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1064539008311 tetramer interface [polypeptide binding]; other site 1064539008312 heme binding pocket [chemical binding]; other site 1064539008313 NADPH binding site [chemical binding]; other site 1064539008314 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1064539008315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539008316 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1064539008317 dimerization interface [polypeptide binding]; other site 1064539008318 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1064539008319 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1064539008320 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1064539008321 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1064539008322 mannonate dehydratase; Provisional; Region: PRK03906 1064539008323 mannonate dehydratase; Region: uxuA; TIGR00695 1064539008324 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1064539008325 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1064539008326 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1064539008327 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539008328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539008329 DNA-binding site [nucleotide binding]; DNA binding site 1064539008330 FCD domain; Region: FCD; pfam07729 1064539008331 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064539008332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539008333 DNA-binding site [nucleotide binding]; DNA binding site 1064539008334 FCD domain; Region: FCD; pfam07729 1064539008335 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1064539008336 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1064539008337 NADP binding site [chemical binding]; other site 1064539008338 homodimer interface [polypeptide binding]; other site 1064539008339 active site 1064539008340 Cupin domain; Region: Cupin_2; pfam07883 1064539008341 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539008342 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539008343 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1064539008344 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064539008345 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064539008346 active site 1064539008347 catalytic tetrad [active] 1064539008348 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539008349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539008350 DNA-binding site [nucleotide binding]; DNA binding site 1064539008351 FCD domain; Region: FCD; pfam07729 1064539008352 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1064539008353 active site 1064539008354 dimer interfaces [polypeptide binding]; other site 1064539008355 catalytic residues [active] 1064539008356 glucuronate isomerase; Reviewed; Region: PRK02925 1064539008357 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1064539008358 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1064539008359 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1064539008360 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1064539008361 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064539008362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539008363 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1064539008364 dimerization interface [polypeptide binding]; other site 1064539008365 substrate binding pocket [chemical binding]; other site 1064539008366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1064539008367 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1064539008368 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1064539008369 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1064539008370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1064539008371 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1064539008372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064539008373 Ligand Binding Site [chemical binding]; other site 1064539008374 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539008375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539008376 active site 1064539008377 phosphorylation site [posttranslational modification] 1064539008378 intermolecular recognition site; other site 1064539008379 dimerization interface [polypeptide binding]; other site 1064539008380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539008381 DNA binding site [nucleotide binding] 1064539008382 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1064539008383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539008384 HAMP domain; Region: HAMP; pfam00672 1064539008385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539008386 dimer interface [polypeptide binding]; other site 1064539008387 phosphorylation site [posttranslational modification] 1064539008388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539008389 ATP binding site [chemical binding]; other site 1064539008390 Mg2+ binding site [ion binding]; other site 1064539008391 G-X-G motif; other site 1064539008392 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1064539008393 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064539008394 hypothetical protein; Provisional; Region: PRK06850 1064539008395 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1064539008396 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539008397 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539008398 DNA binding residues [nucleotide binding] 1064539008399 dimerization interface [polypeptide binding]; other site 1064539008400 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064539008401 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1064539008402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539008403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539008404 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1064539008405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539008406 dimer interface [polypeptide binding]; other site 1064539008407 conserved gate region; other site 1064539008408 putative PBP binding loops; other site 1064539008409 ABC-ATPase subunit interface; other site 1064539008410 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1064539008411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539008412 DNA-binding site [nucleotide binding]; DNA binding site 1064539008413 UTRA domain; Region: UTRA; pfam07702 1064539008414 DctM-like transporters; Region: DctM; pfam06808 1064539008415 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1064539008416 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1064539008417 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1064539008418 Amidase; Region: Amidase; cl11426 1064539008419 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1064539008420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539008421 DNA-binding site [nucleotide binding]; DNA binding site 1064539008422 UTRA domain; Region: UTRA; pfam07702 1064539008423 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539008424 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064539008425 active site 1064539008426 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1064539008427 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1064539008428 putative active site [active] 1064539008429 putative catalytic site [active] 1064539008430 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1064539008431 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539008432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539008433 putative substrate translocation pore; other site 1064539008434 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539008435 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1064539008436 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1064539008437 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1064539008438 putative NAD(P) binding site [chemical binding]; other site 1064539008439 putative active site [active] 1064539008440 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539008441 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539008442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539008443 binding surface 1064539008444 TPR motif; other site 1064539008445 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1064539008446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539008447 binding surface 1064539008448 TPR motif; other site 1064539008449 TPR repeat; Region: TPR_11; pfam13414 1064539008450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539008451 binding surface 1064539008452 TPR motif; other site 1064539008453 RNA polymerase sigma factor; Reviewed; Region: PRK05602 1064539008454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539008455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539008456 DNA binding residues [nucleotide binding] 1064539008457 Heavy-metal resistance; Region: Metal_resist; pfam13801 1064539008458 dimer interface [polypeptide binding]; other site 1064539008459 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1064539008460 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1064539008461 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1064539008462 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064539008463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539008464 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1064539008465 substrate binding pocket [chemical binding]; other site 1064539008466 dimerization interface [polypeptide binding]; other site 1064539008467 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064539008468 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1064539008469 dimer interface [polypeptide binding]; other site 1064539008470 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064539008471 active site 1064539008472 metal binding site [ion binding]; metal-binding site 1064539008473 glutathione binding site [chemical binding]; other site 1064539008474 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1064539008475 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1064539008476 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1064539008477 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1064539008478 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1064539008479 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1064539008480 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539008481 putative homodimer interface [polypeptide binding]; other site 1064539008482 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1064539008483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1064539008484 UDP-galactopyranose mutase; Region: GLF; pfam03275 1064539008485 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1064539008486 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1064539008487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539008488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539008489 Walker A/P-loop; other site 1064539008490 ATP binding site [chemical binding]; other site 1064539008491 Q-loop/lid; other site 1064539008492 ABC transporter signature motif; other site 1064539008493 Walker B; other site 1064539008494 D-loop; other site 1064539008495 H-loop/switch region; other site 1064539008496 PAS fold; Region: PAS_4; pfam08448 1064539008497 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1064539008498 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1064539008499 PAS fold; Region: PAS_4; pfam08448 1064539008500 PAS domain S-box; Region: sensory_box; TIGR00229 1064539008501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539008502 putative active site [active] 1064539008503 heme pocket [chemical binding]; other site 1064539008504 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539008505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539008506 dimer interface [polypeptide binding]; other site 1064539008507 phosphorylation site [posttranslational modification] 1064539008508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539008509 ATP binding site [chemical binding]; other site 1064539008510 Mg2+ binding site [ion binding]; other site 1064539008511 G-X-G motif; other site 1064539008512 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539008513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539008514 active site 1064539008515 phosphorylation site [posttranslational modification] 1064539008516 intermolecular recognition site; other site 1064539008517 dimerization interface [polypeptide binding]; other site 1064539008518 uracil transporter; Provisional; Region: PRK10720 1064539008519 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1064539008520 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1064539008521 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539008522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539008523 metal binding site [ion binding]; metal-binding site 1064539008524 active site 1064539008525 I-site; other site 1064539008526 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1064539008527 Amidase; Region: Amidase; cl11426 1064539008528 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1064539008529 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1064539008530 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 1064539008531 Imelysin; Region: Peptidase_M75; cl09159 1064539008532 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1064539008533 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1064539008534 Imelysin; Region: Peptidase_M75; cl09159 1064539008535 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1064539008536 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1064539008537 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1064539008538 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1064539008539 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1064539008540 BON domain; Region: BON; pfam04972 1064539008541 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1064539008542 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1064539008543 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 1064539008544 Type IV pili component [Cell motility and secretion]; Region: COG5461 1064539008545 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 1064539008546 potential frameshift: common BLAST hit: gi|217978828|ref|YP_002362975.1| response regulator receiver protein 1064539008547 Type II/IV secretion system protein; Region: T2SE; pfam00437 1064539008548 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1064539008549 ATP binding site [chemical binding]; other site 1064539008550 Walker A motif; other site 1064539008551 hexamer interface [polypeptide binding]; other site 1064539008552 Walker B motif; other site 1064539008553 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1064539008554 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1064539008555 potential frameshift: common BLAST hit: gi|148261008|ref|YP_001235135.1| type II secretion system protein 1064539008556 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1064539008557 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1064539008558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539008559 TPR motif; other site 1064539008560 binding surface 1064539008561 TadE-like protein; Region: TadE; pfam07811 1064539008562 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1064539008563 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1064539008564 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1064539008565 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539008566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539008567 active site 1064539008568 phosphorylation site [posttranslational modification] 1064539008569 intermolecular recognition site; other site 1064539008570 dimerization interface [polypeptide binding]; other site 1064539008571 Helix-turn-helix domain; Region: HTH_18; pfam12833 1064539008572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539008573 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1064539008574 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1064539008575 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539008576 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539008577 catalytic residue [active] 1064539008578 Sporulation related domain; Region: SPOR; pfam05036 1064539008579 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1064539008580 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1064539008581 hypothetical protein; Validated; Region: PRK07198 1064539008582 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 1064539008583 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1064539008584 dimerization interface [polypeptide binding]; other site 1064539008585 active site 1064539008586 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 1064539008587 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1064539008588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064539008589 active site 1064539008590 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1064539008591 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1064539008592 putative ligand binding site [chemical binding]; other site 1064539008593 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1064539008594 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1064539008595 Walker A/P-loop; other site 1064539008596 ATP binding site [chemical binding]; other site 1064539008597 Q-loop/lid; other site 1064539008598 ABC transporter signature motif; other site 1064539008599 Walker B; other site 1064539008600 D-loop; other site 1064539008601 H-loop/switch region; other site 1064539008602 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1064539008603 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539008604 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1064539008605 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1064539008606 TM-ABC transporter signature motif; other site 1064539008607 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539008608 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1064539008609 TM-ABC transporter signature motif; other site 1064539008610 cytosine deaminase; Validated; Region: PRK07572 1064539008611 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1064539008612 active site 1064539008613 Cache domain; Region: Cache_1; pfam02743 1064539008614 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539008615 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539008616 dimer interface [polypeptide binding]; other site 1064539008617 putative CheW interface [polypeptide binding]; other site 1064539008618 PAS domain S-box; Region: sensory_box; TIGR00229 1064539008619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539008620 putative active site [active] 1064539008621 heme pocket [chemical binding]; other site 1064539008622 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1064539008623 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064539008624 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064539008625 MarR family; Region: MarR_2; pfam12802 1064539008626 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1064539008627 Coenzyme A binding pocket [chemical binding]; other site 1064539008628 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1064539008629 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1064539008630 DNA binding residues [nucleotide binding] 1064539008631 dimer interface [polypeptide binding]; other site 1064539008632 [2Fe-2S] cluster binding site [ion binding]; other site 1064539008633 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064539008634 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064539008635 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539008636 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12605683, 3531194; Product type e : enzyme 1064539008637 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12605683, 3531194; Product type e : enzyme 1064539008638 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1064539008639 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 1064539008640 putative dimer interface [polypeptide binding]; other site 1064539008641 [2Fe-2S] cluster binding site [ion binding]; other site 1064539008642 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1064539008643 SLBB domain; Region: SLBB; pfam10531 1064539008644 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1064539008645 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1064539008646 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1064539008647 PYR/PP interface [polypeptide binding]; other site 1064539008648 dimer interface [polypeptide binding]; other site 1064539008649 TPP binding site [chemical binding]; other site 1064539008650 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064539008651 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1064539008652 TPP-binding site; other site 1064539008653 dimer interface [polypeptide binding]; other site 1064539008654 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539008655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539008656 DNA-binding site [nucleotide binding]; DNA binding site 1064539008657 FCD domain; Region: FCD; pfam07729 1064539008658 putative lipid kinase; Reviewed; Region: PRK13057 1064539008659 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1064539008660 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1064539008661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539008662 motif II; other site 1064539008663 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1064539008664 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1064539008665 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1064539008666 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1064539008667 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1064539008668 NAD binding site [chemical binding]; other site 1064539008669 Phe binding site; other site 1064539008670 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1064539008671 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1064539008672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539008673 S-adenosylmethionine binding site [chemical binding]; other site 1064539008674 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539008675 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539008676 DNA binding site [nucleotide binding] 1064539008677 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1064539008678 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1064539008679 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539008680 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1064539008681 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1064539008682 FliG C-terminal domain; Region: FliG_C; pfam01706 1064539008683 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1064539008684 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1064539008685 flagellar assembly protein H; Validated; Region: fliH; PRK06032 1064539008686 Flagellar assembly protein FliH; Region: FliH; pfam02108 1064539008687 Evidence 2b : Function of strongly homologous gene; PubMedId : 17572072, 1482109; Product type s : structure 1064539008688 Evidence 2b : Function of strongly homologous gene; PubMedId : 17572072, 1482109; Product type s : structure 1064539008689 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 1064539008690 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1064539008691 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1064539008692 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1064539008693 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 1064539008694 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1064539008695 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539008696 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539008697 Nidogen-like; Region: NIDO; cl02648 1064539008698 Calx-beta domain; Region: Calx-beta; cl02522 1064539008699 von Willebrand factor type D domain; Region: VWD; pfam00094 1064539008700 Calx-beta domain; Region: Calx-beta; cl02522 1064539008701 Calx-beta domain; Region: Calx-beta; cl02522 1064539008702 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539008703 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539008704 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539008705 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539008706 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539008707 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 1064539008708 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 1064539008709 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 1064539008710 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1064539008711 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1064539008712 [4Fe-4S] binding site [ion binding]; other site 1064539008713 molybdopterin cofactor binding site; other site 1064539008714 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1064539008715 molybdopterin cofactor binding site; other site 1064539008716 NapD protein; Region: NapD; pfam03927 1064539008717 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 1064539008718 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1064539008719 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1064539008720 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1064539008721 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 1064539008722 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1064539008723 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 1064539008724 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064539008725 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 1064539008726 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1064539008727 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1064539008728 Evidence 2b : Function of strongly homologous gene; PubMedId : 9858749; Product type cp : cell process 1064539008729 Evidence 2b : Function of strongly homologous gene; PubMedId : 9858749; Product type cp : cell process 1064539008730 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1064539008731 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1064539008732 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064539008733 ligand binding site [chemical binding]; other site 1064539008734 major facilitator superfamily transporter; Provisional; Region: PRK05122 1064539008735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539008736 putative substrate translocation pore; other site 1064539008737 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 1064539008738 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1064539008739 GIY-YIG motif/motif A; other site 1064539008740 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1064539008741 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1064539008742 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1064539008743 Killing trait; Region: RebB; pfam11747 1064539008744 Killing trait; Region: RebB; pfam11747 1064539008745 Killing trait; Region: RebB; pfam11747 1064539008746 Killing trait; Region: RebB; pfam11747 1064539008747 Killing trait; Region: RebB; pfam11747 1064539008748 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1064539008749 potential frameshift: common BLAST hit: gi|330819272|ref|YP_004348134.1| transcriptional regulator 1064539008750 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064539008751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539008752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539008753 Walker A motif; other site 1064539008754 ATP binding site [chemical binding]; other site 1064539008755 Walker B motif; other site 1064539008756 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1064539008757 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1064539008758 putative catalytic cysteine [active] 1064539008759 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1064539008760 putative active site [active] 1064539008761 metal binding site [ion binding]; metal-binding site 1064539008762 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064539008763 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1064539008764 active site 1064539008765 catalytic residues [active] 1064539008766 DNA binding site [nucleotide binding] 1064539008767 Int/Topo IB signature motif; other site 1064539008768 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1064539008769 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539008770 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539008771 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539008772 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539008773 TM-ABC transporter signature motif; other site 1064539008774 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539008775 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539008776 TM-ABC transporter signature motif; other site 1064539008777 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539008778 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539008779 Walker A/P-loop; other site 1064539008780 ATP binding site [chemical binding]; other site 1064539008781 Q-loop/lid; other site 1064539008782 ABC transporter signature motif; other site 1064539008783 Walker B; other site 1064539008784 D-loop; other site 1064539008785 H-loop/switch region; other site 1064539008786 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539008787 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539008788 Walker A/P-loop; other site 1064539008789 ATP binding site [chemical binding]; other site 1064539008790 Q-loop/lid; other site 1064539008791 ABC transporter signature motif; other site 1064539008792 Walker B; other site 1064539008793 D-loop; other site 1064539008794 H-loop/switch region; other site 1064539008795 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1064539008796 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1064539008797 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1064539008798 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1064539008799 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1064539008800 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1064539008801 Isochorismatase family; Region: Isochorismatase; pfam00857 1064539008802 catalytic triad [active] 1064539008803 conserved cis-peptide bond; other site 1064539008804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539008805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539008806 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064539008807 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064539008808 DNA binding site [nucleotide binding] 1064539008809 domain linker motif; other site 1064539008810 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 1064539008811 putative dimerization interface [polypeptide binding]; other site 1064539008812 putative ligand binding site [chemical binding]; other site 1064539008813 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064539008814 active site 1064539008815 phosphorylation site [posttranslational modification] 1064539008816 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1064539008817 dimerization domain swap beta strand [polypeptide binding]; other site 1064539008818 regulatory protein interface [polypeptide binding]; other site 1064539008819 active site 1064539008820 regulatory phosphorylation site [posttranslational modification]; other site 1064539008821 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1064539008822 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1064539008823 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1064539008824 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1064539008825 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1064539008826 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1064539008827 active site 1064539008828 P-loop; other site 1064539008829 phosphorylation site [posttranslational modification] 1064539008830 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1064539008831 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1064539008832 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1064539008833 GAF domain; Region: GAF; pfam01590 1064539008834 PAS domain S-box; Region: sensory_box; TIGR00229 1064539008835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539008836 putative active site [active] 1064539008837 heme pocket [chemical binding]; other site 1064539008838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1064539008839 Histidine kinase; Region: HisKA_2; pfam07568 1064539008840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539008841 ATP binding site [chemical binding]; other site 1064539008842 Mg2+ binding site [ion binding]; other site 1064539008843 G-X-G motif; other site 1064539008844 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539008845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539008846 active site 1064539008847 phosphorylation site [posttranslational modification] 1064539008848 intermolecular recognition site; other site 1064539008849 dimerization interface [polypeptide binding]; other site 1064539008850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539008851 DNA binding residues [nucleotide binding] 1064539008852 dimerization interface [polypeptide binding]; other site 1064539008853 Predicted integral membrane protein [Function unknown]; Region: COG5652 1064539008854 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1064539008855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539008856 binding surface 1064539008857 TPR motif; other site 1064539008858 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 1064539008859 GDP-Fucose binding site [chemical binding]; other site 1064539008860 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1064539008861 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1064539008862 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1064539008863 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1064539008864 metal binding site [ion binding]; metal-binding site 1064539008865 putative dimer interface [polypeptide binding]; other site 1064539008866 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1064539008867 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539008868 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539008869 Walker A/P-loop; other site 1064539008870 ATP binding site [chemical binding]; other site 1064539008871 Q-loop/lid; other site 1064539008872 ABC transporter signature motif; other site 1064539008873 Walker B; other site 1064539008874 D-loop; other site 1064539008875 H-loop/switch region; other site 1064539008876 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539008877 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539008878 Walker A/P-loop; other site 1064539008879 ATP binding site [chemical binding]; other site 1064539008880 Q-loop/lid; other site 1064539008881 ABC transporter signature motif; other site 1064539008882 Walker B; other site 1064539008883 D-loop; other site 1064539008884 H-loop/switch region; other site 1064539008885 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539008886 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539008887 TM-ABC transporter signature motif; other site 1064539008888 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539008889 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539008890 TM-ABC transporter signature motif; other site 1064539008891 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1064539008892 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539008893 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1064539008894 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 1064539008895 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1064539008896 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1064539008897 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539008898 catalytic residue [active] 1064539008899 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1064539008900 homotrimer interaction site [polypeptide binding]; other site 1064539008901 putative active site [active] 1064539008902 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1064539008903 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064539008904 putative DNA binding site [nucleotide binding]; other site 1064539008905 putative Zn2+ binding site [ion binding]; other site 1064539008906 AsnC family; Region: AsnC_trans_reg; pfam01037 1064539008907 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064539008908 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1064539008909 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539008910 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1064539008911 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064539008912 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539008913 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1064539008914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1064539008915 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1064539008916 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1064539008917 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1064539008918 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1064539008919 putative catalytic cysteine [active] 1064539008920 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1064539008921 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1064539008922 CoA-ligase; Region: Ligase_CoA; pfam00549 1064539008923 CoA binding domain; Region: CoA_binding; smart00881 1064539008924 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1064539008925 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1064539008926 potential frameshift: common BLAST hit: gi|319785594|ref|YP_004145070.1| molybdopterin oxidoreductase Fe4S4 region 1064539008927 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1064539008928 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064539008929 molybdopterin cofactor binding site; other site 1064539008930 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064539008931 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064539008932 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1064539008933 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 1064539008934 putative molybdopterin cofactor binding site; other site 1064539008935 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1064539008936 4Fe-4S binding domain; Region: Fer4; pfam00037 1064539008937 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1064539008938 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 1064539008939 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1064539008940 PYR/PP interface [polypeptide binding]; other site 1064539008941 dimer interface [polypeptide binding]; other site 1064539008942 TPP binding site [chemical binding]; other site 1064539008943 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064539008944 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 1064539008945 TPP-binding site; other site 1064539008946 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1064539008947 ParB-like nuclease domain; Region: ParB; smart00470 1064539008948 KorB domain; Region: KorB; pfam08535 1064539008949 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539008950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539008951 non-specific DNA binding site [nucleotide binding]; other site 1064539008952 salt bridge; other site 1064539008953 sequence-specific DNA binding site [nucleotide binding]; other site 1064539008954 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1064539008955 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539008956 P-loop; other site 1064539008957 Magnesium ion binding site [ion binding]; other site 1064539008958 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539008959 Magnesium ion binding site [ion binding]; other site 1064539008960 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1064539008961 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1064539008962 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1064539008963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539008964 motif II; other site 1064539008965 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1064539008966 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1064539008967 Predicted membrane protein [Function unknown]; Region: COG2855 1064539008968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539008969 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1064539008970 putative dimerization interface [polypeptide binding]; other site 1064539008971 Replication initiator protein A; Region: RPA; cl17860 1064539008972 PAS domain S-box; Region: sensory_box; TIGR00229 1064539008973 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539008974 putative active site [active] 1064539008975 heme pocket [chemical binding]; other site 1064539008976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539008977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1064539008978 dimer interface [polypeptide binding]; other site 1064539008979 phosphorylation site [posttranslational modification] 1064539008980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539008981 ATP binding site [chemical binding]; other site 1064539008982 Mg2+ binding site [ion binding]; other site 1064539008983 G-X-G motif; other site 1064539008984 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539008985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539008986 active site 1064539008987 phosphorylation site [posttranslational modification] 1064539008988 intermolecular recognition site; other site 1064539008989 dimerization interface [polypeptide binding]; other site 1064539008990 circadian clock protein KaiC; Reviewed; Region: PRK09302 1064539008991 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1064539008992 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1064539008993 Walker A motif; other site 1064539008994 Walker A motif; other site 1064539008995 ATP binding site [chemical binding]; other site 1064539008996 Walker B motif; other site 1064539008997 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1064539008998 Walker A motif; other site 1064539008999 ATP binding site [chemical binding]; other site 1064539009000 Walker B motif; other site 1064539009001 Dehydratase family; Region: ILVD_EDD; cl00340 1064539009002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539009003 dimer interface [polypeptide binding]; other site 1064539009004 phosphorylation site [posttranslational modification] 1064539009005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539009006 ATP binding site [chemical binding]; other site 1064539009007 Mg2+ binding site [ion binding]; other site 1064539009008 G-X-G motif; other site 1064539009009 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539009010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539009011 active site 1064539009012 phosphorylation site [posttranslational modification] 1064539009013 intermolecular recognition site; other site 1064539009014 dimerization interface [polypeptide binding]; other site 1064539009015 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1064539009016 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539009017 EamA-like transporter family; Region: EamA; cl17759 1064539009018 aldehyde dehydrogenase family 7 member; Region: PLN02315 1064539009019 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1064539009020 tetrameric interface [polypeptide binding]; other site 1064539009021 NAD binding site [chemical binding]; other site 1064539009022 catalytic residues [active] 1064539009023 Evidence 2b : Function of strongly homologous gene; PubMedId : 2989781, 2989782; Product type e : enzyme 1064539009024 Evidence 2b : Function of strongly homologous gene; PubMedId : 2989781, 2989782; Product type e : enzyme 1064539009025 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064539009026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539009027 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1064539009028 dimerization interface [polypeptide binding]; other site 1064539009029 substrate binding pocket [chemical binding]; other site 1064539009030 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539009031 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1064539009032 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1064539009033 NADP-binding site; other site 1064539009034 homotetramer interface [polypeptide binding]; other site 1064539009035 substrate binding site [chemical binding]; other site 1064539009036 homodimer interface [polypeptide binding]; other site 1064539009037 active site 1064539009038 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009039 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539009040 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1064539009041 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539009042 active site 1064539009043 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539009044 active site 1064539009045 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009046 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539009047 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1064539009048 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1064539009049 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1064539009050 NAD binding site [chemical binding]; other site 1064539009051 substrate binding site [chemical binding]; other site 1064539009052 homodimer interface [polypeptide binding]; other site 1064539009053 active site 1064539009054 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1064539009055 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1064539009056 NADP binding site [chemical binding]; other site 1064539009057 active site 1064539009058 putative substrate binding site [chemical binding]; other site 1064539009059 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1064539009060 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1064539009061 substrate binding site; other site 1064539009062 tetramer interface; other site 1064539009063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539009064 Coenzyme A binding pocket [chemical binding]; other site 1064539009065 Sel1-like repeats; Region: SEL1; smart00671 1064539009066 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064539009067 Sel1-like repeats; Region: SEL1; smart00671 1064539009068 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064539009069 Sel1-like repeats; Region: SEL1; smart00671 1064539009070 Sel1-like repeats; Region: SEL1; smart00671 1064539009071 Sel1-like repeats; Region: SEL1; smart00671 1064539009072 Sel1-like repeats; Region: SEL1; smart00671 1064539009073 Sel1-like repeats; Region: SEL1; smart00671 1064539009074 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1064539009075 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539009076 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539009077 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 1064539009078 putative active site [active] 1064539009079 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1064539009080 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539009081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539009082 Walker A/P-loop; other site 1064539009083 ATP binding site [chemical binding]; other site 1064539009084 Q-loop/lid; other site 1064539009085 ABC transporter signature motif; other site 1064539009086 Walker B; other site 1064539009087 D-loop; other site 1064539009088 H-loop/switch region; other site 1064539009089 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1064539009090 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1064539009091 NADP binding site [chemical binding]; other site 1064539009092 active site 1064539009093 putative substrate binding site [chemical binding]; other site 1064539009094 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1064539009095 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009096 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1064539009097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009098 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1064539009099 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1064539009100 NADP-binding site; other site 1064539009101 homotetramer interface [polypeptide binding]; other site 1064539009102 substrate binding site [chemical binding]; other site 1064539009103 homodimer interface [polypeptide binding]; other site 1064539009104 active site 1064539009105 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1064539009106 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1064539009107 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1064539009108 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1064539009109 Walker A/P-loop; other site 1064539009110 ATP binding site [chemical binding]; other site 1064539009111 Q-loop/lid; other site 1064539009112 ABC transporter signature motif; other site 1064539009113 Walker B; other site 1064539009114 D-loop; other site 1064539009115 H-loop/switch region; other site 1064539009116 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1064539009117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539009118 motif II; other site 1064539009119 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1064539009120 active site 1064539009121 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584 1064539009122 putative active site [active] 1064539009123 catalytic site [active] 1064539009124 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1064539009125 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1064539009126 Ligand binding site; other site 1064539009127 Putative Catalytic site; other site 1064539009128 DXD motif; other site 1064539009129 Predicted membrane protein [Function unknown]; Region: COG2246 1064539009130 GtrA-like protein; Region: GtrA; pfam04138 1064539009131 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1064539009132 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 1064539009133 Ligand binding site; other site 1064539009134 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539009135 active site 1064539009136 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1064539009137 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1064539009138 active site 1064539009139 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539009140 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1064539009141 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064539009142 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1064539009143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539009144 S-adenosylmethionine binding site [chemical binding]; other site 1064539009145 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 1064539009146 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009147 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 1064539009148 putative ADP-binding pocket [chemical binding]; other site 1064539009149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539009150 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539009151 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1064539009152 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1064539009153 Probable Catalytic site; other site 1064539009154 metal-binding site 1064539009155 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539009156 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539009157 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1064539009158 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1064539009159 NAD binding site [chemical binding]; other site 1064539009160 homodimer interface [polypeptide binding]; other site 1064539009161 active site 1064539009162 substrate binding site [chemical binding]; other site 1064539009163 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1064539009164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539009165 S-adenosylmethionine binding site [chemical binding]; other site 1064539009166 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1064539009167 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1064539009168 Ligand binding site; other site 1064539009169 Putative Catalytic site; other site 1064539009170 DXD motif; other site 1064539009171 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1064539009172 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1064539009173 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1064539009174 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539009175 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1064539009176 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539009177 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539009178 active site 1064539009179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539009180 TPR motif; other site 1064539009181 binding surface 1064539009182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539009183 TPR motif; other site 1064539009184 binding surface 1064539009185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539009186 TPR motif; other site 1064539009187 binding surface 1064539009188 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1064539009189 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539009190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539009191 NAD(P) binding site [chemical binding]; other site 1064539009192 active site 1064539009193 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1064539009194 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1064539009195 inhibitor-cofactor binding pocket; inhibition site 1064539009196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539009197 catalytic residue [active] 1064539009198 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1064539009199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539009200 S-adenosylmethionine binding site [chemical binding]; other site 1064539009201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539009202 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1064539009203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539009204 S-adenosylmethionine binding site [chemical binding]; other site 1064539009205 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009206 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539009207 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539009208 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 1064539009209 NAD binding site [chemical binding]; other site 1064539009210 homotetramer interface [polypeptide binding]; other site 1064539009211 homodimer interface [polypeptide binding]; other site 1064539009212 active site 1064539009213 substrate binding site [chemical binding]; other site 1064539009214 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 1064539009215 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539009216 NAD binding site [chemical binding]; other site 1064539009217 homotetramer interface [polypeptide binding]; other site 1064539009218 homodimer interface [polypeptide binding]; other site 1064539009219 active site 1064539009220 substrate binding site [chemical binding]; other site 1064539009221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539009222 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1064539009223 FeS/SAM binding site; other site 1064539009224 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1064539009225 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009226 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539009227 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255 1064539009228 putative nucleotide binding site [chemical binding]; other site 1064539009229 putative substrate binding site [chemical binding]; other site 1064539009230 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1064539009231 nucleotide binding site [chemical binding]; other site 1064539009232 substrate binding site [chemical binding]; other site 1064539009233 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009234 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 1064539009235 putative ADP-binding pocket [chemical binding]; other site 1064539009236 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1064539009237 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1064539009238 dimer interface [polypeptide binding]; other site 1064539009239 ADP-ribose binding site [chemical binding]; other site 1064539009240 active site 1064539009241 nudix motif; other site 1064539009242 metal binding site [ion binding]; metal-binding site 1064539009243 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1064539009244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1064539009245 hypothetical protein; Validated; Region: PRK06201 1064539009246 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1064539009247 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1064539009248 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1064539009249 NAD(P) binding site [chemical binding]; other site 1064539009250 homodimer interface [polypeptide binding]; other site 1064539009251 substrate binding site [chemical binding]; other site 1064539009252 active site 1064539009253 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1064539009254 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1064539009255 inhibitor-cofactor binding pocket; inhibition site 1064539009256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539009257 catalytic residue [active] 1064539009258 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1064539009259 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1064539009260 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1064539009261 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1064539009262 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1064539009263 active site 1064539009264 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1064539009265 substrate binding site [chemical binding]; other site 1064539009266 metal binding site [ion binding]; metal-binding site 1064539009267 ParB-like nuclease domain; Region: ParBc; pfam02195 1064539009268 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1064539009269 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539009270 P-loop; other site 1064539009271 Magnesium ion binding site [ion binding]; other site 1064539009272 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539009273 Magnesium ion binding site [ion binding]; other site 1064539009274 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1064539009275 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1064539009276 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1064539009277 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1064539009278 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1064539009279 catalytic residues [active] 1064539009280 catalytic nucleophile [active] 1064539009281 Presynaptic Site I dimer interface [polypeptide binding]; other site 1064539009282 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1064539009283 Synaptic Flat tetramer interface [polypeptide binding]; other site 1064539009284 Synaptic Site I dimer interface [polypeptide binding]; other site 1064539009285 DNA binding site [nucleotide binding] 1064539009286 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1064539009287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539009288 active site 1064539009289 motif I; other site 1064539009290 motif II; other site 1064539009291 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 1064539009292 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1064539009293 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539009294 NAD binding site [chemical binding]; other site 1064539009295 putative substrate binding site 2 [chemical binding]; other site 1064539009296 putative substrate binding site 1 [chemical binding]; other site 1064539009297 active site 1064539009298 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1064539009299 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1064539009300 CysD dimerization site [polypeptide binding]; other site 1064539009301 G1 box; other site 1064539009302 putative GEF interaction site [polypeptide binding]; other site 1064539009303 GTP/Mg2+ binding site [chemical binding]; other site 1064539009304 Switch I region; other site 1064539009305 G2 box; other site 1064539009306 G3 box; other site 1064539009307 Switch II region; other site 1064539009308 G4 box; other site 1064539009309 G5 box; other site 1064539009310 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1064539009311 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1064539009312 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1064539009313 ligand-binding site [chemical binding]; other site 1064539009314 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1064539009315 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1064539009316 Active Sites [active] 1064539009317 hypothetical protein; Validated; Region: PRK06748; cl17661 1064539009318 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1064539009319 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539009320 active site 1064539009321 Protein of unknown function (DUF563); Region: DUF563; pfam04577 1064539009322 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1064539009323 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1064539009324 Probable Catalytic site; other site 1064539009325 metal-binding site 1064539009326 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1064539009327 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539009328 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1064539009329 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 1064539009330 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539009331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009332 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009333 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539009334 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1064539009335 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1064539009336 Substrate binding site; other site 1064539009337 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1064539009338 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1064539009339 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1064539009340 putative carbohydrate binding site [chemical binding]; other site 1064539009341 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1064539009342 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1064539009343 putative active site [active] 1064539009344 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1064539009345 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009346 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1064539009347 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009348 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539009349 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1064539009350 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1064539009351 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1064539009352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009353 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539009354 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009355 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539009356 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1064539009357 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009358 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1064539009359 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1064539009360 NADP binding site [chemical binding]; other site 1064539009361 homopentamer interface [polypeptide binding]; other site 1064539009362 substrate binding site [chemical binding]; other site 1064539009363 active site 1064539009364 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1064539009365 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1064539009366 putative ribose interaction site [chemical binding]; other site 1064539009367 putative ADP binding site [chemical binding]; other site 1064539009368 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1064539009369 active site 1064539009370 nucleotide binding site [chemical binding]; other site 1064539009371 HIGH motif; other site 1064539009372 KMSKS motif; other site 1064539009373 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1064539009374 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1064539009375 dimer interface [polypeptide binding]; other site 1064539009376 active site 1064539009377 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009378 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1064539009379 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 1064539009380 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1064539009381 Probable Catalytic site; other site 1064539009382 metal-binding site 1064539009383 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1064539009384 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1064539009385 Probable Catalytic site; other site 1064539009386 metal-binding site 1064539009387 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1064539009388 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1064539009389 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1064539009390 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1064539009391 Walker A/P-loop; other site 1064539009392 ATP binding site [chemical binding]; other site 1064539009393 Q-loop/lid; other site 1064539009394 ABC transporter signature motif; other site 1064539009395 Walker B; other site 1064539009396 D-loop; other site 1064539009397 H-loop/switch region; other site 1064539009398 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1064539009399 putative carbohydrate binding site [chemical binding]; other site 1064539009400 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1064539009401 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1064539009402 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009403 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009404 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539009405 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1064539009406 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539009407 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539009408 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1064539009409 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539009410 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1064539009411 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1064539009412 Walker A/P-loop; other site 1064539009413 ATP binding site [chemical binding]; other site 1064539009414 Q-loop/lid; other site 1064539009415 ABC transporter signature motif; other site 1064539009416 Walker B; other site 1064539009417 D-loop; other site 1064539009418 H-loop/switch region; other site 1064539009419 TOBE domain; Region: TOBE_2; pfam08402 1064539009420 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1064539009421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539009422 dimer interface [polypeptide binding]; other site 1064539009423 conserved gate region; other site 1064539009424 putative PBP binding loops; other site 1064539009425 ABC-ATPase subunit interface; other site 1064539009426 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1064539009427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539009428 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1064539009429 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539009430 PAS fold; Region: PAS_4; pfam08448 1064539009431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539009432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539009433 dimer interface [polypeptide binding]; other site 1064539009434 phosphorylation site [posttranslational modification] 1064539009435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539009436 ATP binding site [chemical binding]; other site 1064539009437 Mg2+ binding site [ion binding]; other site 1064539009438 G-X-G motif; other site 1064539009439 Protein of unknown function DUF45; Region: DUF45; pfam01863 1064539009440 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1064539009441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539009442 putative substrate translocation pore; other site 1064539009443 MgtC family; Region: MgtC; pfam02308 1064539009444 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1064539009445 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1064539009446 dimer interface [polypeptide binding]; other site 1064539009447 active site 1064539009448 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064539009449 catalytic residues [active] 1064539009450 substrate binding site [chemical binding]; other site 1064539009451 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1064539009452 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1064539009453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539009454 motif II; other site 1064539009455 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1064539009456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1064539009457 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1064539009458 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1064539009459 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1064539009460 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1064539009461 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1064539009462 putative deacylase active site [active] 1064539009463 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1064539009464 Predicted permeases [General function prediction only]; Region: COG0679 1064539009465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1064539009466 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539009467 dimerization interface [polypeptide binding]; other site 1064539009468 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539009469 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539009470 dimer interface [polypeptide binding]; other site 1064539009471 putative CheW interface [polypeptide binding]; other site 1064539009472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1064539009473 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1064539009474 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064539009475 Zn2+ binding site [ion binding]; other site 1064539009476 Mg2+ binding site [ion binding]; other site 1064539009477 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1064539009478 Calx-beta domain; Region: Calx-beta; cl02522 1064539009479 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539009480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539009481 binding surface 1064539009482 TPR motif; other site 1064539009483 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1064539009484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539009485 binding surface 1064539009486 TPR motif; other site 1064539009487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539009488 S-adenosylmethionine binding site [chemical binding]; other site 1064539009489 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 1064539009490 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1064539009491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539009492 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1064539009493 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1064539009494 purine monophosphate binding site [chemical binding]; other site 1064539009495 dimer interface [polypeptide binding]; other site 1064539009496 putative catalytic residues [active] 1064539009497 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1064539009498 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1064539009499 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 1064539009500 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1064539009501 NusB family; Region: NusB; pfam01029 1064539009502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539009503 S-adenosylmethionine binding site [chemical binding]; other site 1064539009504 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1064539009505 Peptidase family M48; Region: Peptidase_M48; cl12018 1064539009506 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 1064539009507 acetyl-CoA synthetase; Provisional; Region: PRK00174 1064539009508 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1064539009509 active site 1064539009510 CoA binding site [chemical binding]; other site 1064539009511 acyl-activating enzyme (AAE) consensus motif; other site 1064539009512 AMP binding site [chemical binding]; other site 1064539009513 acetate binding site [chemical binding]; other site 1064539009514 EVE domain; Region: EVE; pfam01878 1064539009515 YciI-like protein; Reviewed; Region: PRK12863 1064539009516 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 1064539009517 HemY protein N-terminus; Region: HemY_N; pfam07219 1064539009518 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1064539009519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 1064539009520 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1064539009521 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1064539009522 active site 1064539009523 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1064539009524 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1064539009525 domain interfaces; other site 1064539009526 active site 1064539009527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539009528 S-adenosylmethionine binding site [chemical binding]; other site 1064539009529 UGMP family protein; Validated; Region: PRK09604 1064539009530 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1064539009531 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1064539009532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539009533 Coenzyme A binding pocket [chemical binding]; other site 1064539009534 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1064539009535 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1064539009536 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1064539009537 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539009538 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539009539 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539009540 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1064539009541 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539009542 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539009543 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539009544 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539009545 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1064539009546 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539009547 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064539009548 protein binding site [polypeptide binding]; other site 1064539009549 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1064539009550 NnrU protein; Region: NnrU; pfam07298 1064539009551 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1064539009552 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064539009553 ligand binding site [chemical binding]; other site 1064539009554 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539009555 dimer interface [polypeptide binding]; other site 1064539009556 putative CheW interface [polypeptide binding]; other site 1064539009557 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1064539009558 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1064539009559 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1064539009560 putative active site [active] 1064539009561 putative active site [active] 1064539009562 catalytic site [active] 1064539009563 catalytic site [active] 1064539009564 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1064539009565 putative active site [active] 1064539009566 catalytic site [active] 1064539009567 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539009568 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539009569 putative active site [active] 1064539009570 heme pocket [chemical binding]; other site 1064539009571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539009572 ATP binding site [chemical binding]; other site 1064539009573 Mg2+ binding site [ion binding]; other site 1064539009574 G-X-G motif; other site 1064539009575 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1064539009576 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1064539009577 catalytic triad [active] 1064539009578 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 1064539009579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1064539009580 dimer interface [polypeptide binding]; other site 1064539009581 phosphorylation site [posttranslational modification] 1064539009582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539009583 ATP binding site [chemical binding]; other site 1064539009584 Mg2+ binding site [ion binding]; other site 1064539009585 G-X-G motif; other site 1064539009586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539009587 dimerization interface [polypeptide binding]; other site 1064539009588 PAS fold; Region: PAS_4; pfam08448 1064539009589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539009590 putative active site [active] 1064539009591 heme pocket [chemical binding]; other site 1064539009592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1064539009593 PAS domain; Region: PAS_9; pfam13426 1064539009594 putative active site [active] 1064539009595 heme pocket [chemical binding]; other site 1064539009596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539009597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539009598 dimer interface [polypeptide binding]; other site 1064539009599 phosphorylation site [posttranslational modification] 1064539009600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539009601 ATP binding site [chemical binding]; other site 1064539009602 Mg2+ binding site [ion binding]; other site 1064539009603 G-X-G motif; other site 1064539009604 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539009605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539009606 active site 1064539009607 phosphorylation site [posttranslational modification] 1064539009608 intermolecular recognition site; other site 1064539009609 dimerization interface [polypeptide binding]; other site 1064539009610 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1064539009611 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539009612 substrate binding pocket [chemical binding]; other site 1064539009613 membrane-bound complex binding site; other site 1064539009614 hinge residues; other site 1064539009615 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539009616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539009617 dimer interface [polypeptide binding]; other site 1064539009618 conserved gate region; other site 1064539009619 putative PBP binding loops; other site 1064539009620 ABC-ATPase subunit interface; other site 1064539009621 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539009622 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539009623 Walker A/P-loop; other site 1064539009624 ATP binding site [chemical binding]; other site 1064539009625 Q-loop/lid; other site 1064539009626 ABC transporter signature motif; other site 1064539009627 Walker B; other site 1064539009628 D-loop; other site 1064539009629 H-loop/switch region; other site 1064539009630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539009631 Coenzyme A binding pocket [chemical binding]; other site 1064539009632 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1064539009633 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1064539009634 GTP cyclohydrolase I; Provisional; Region: PLN03044 1064539009635 active site 1064539009636 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539009637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539009638 active site 1064539009639 phosphorylation site [posttranslational modification] 1064539009640 intermolecular recognition site; other site 1064539009641 dimerization interface [polypeptide binding]; other site 1064539009642 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539009643 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1064539009644 putative deacylase active site [active] 1064539009645 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1064539009646 active site 1064539009647 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539009648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539009649 dimer interface [polypeptide binding]; other site 1064539009650 phosphorylation site [posttranslational modification] 1064539009651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539009652 ATP binding site [chemical binding]; other site 1064539009653 Mg2+ binding site [ion binding]; other site 1064539009654 G-X-G motif; other site 1064539009655 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1064539009656 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1064539009657 catalytic center binding site [active] 1064539009658 ATP binding site [chemical binding]; other site 1064539009659 dihydromonapterin reductase; Provisional; Region: PRK06483 1064539009660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539009661 NAD(P) binding site [chemical binding]; other site 1064539009662 active site 1064539009663 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1064539009664 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1064539009665 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1064539009666 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1064539009667 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1064539009668 substrate binding site [chemical binding]; other site 1064539009669 active site 1064539009670 catalytic residues [active] 1064539009671 heterodimer interface [polypeptide binding]; other site 1064539009672 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1064539009673 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1064539009674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539009675 catalytic residue [active] 1064539009676 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539009677 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1064539009678 substrate binding pocket [chemical binding]; other site 1064539009679 membrane-bound complex binding site; other site 1064539009680 hinge residues; other site 1064539009681 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539009682 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539009683 PAS fold; Region: PAS_7; pfam12860 1064539009684 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539009685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539009686 dimer interface [polypeptide binding]; other site 1064539009687 phosphorylation site [posttranslational modification] 1064539009688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539009689 ATP binding site [chemical binding]; other site 1064539009690 Mg2+ binding site [ion binding]; other site 1064539009691 G-X-G motif; other site 1064539009692 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1064539009693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539009694 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539009695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539009696 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539009697 dimerization interface [polypeptide binding]; other site 1064539009698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539009699 ATP binding site [chemical binding]; other site 1064539009700 Mg2+ binding site [ion binding]; other site 1064539009701 G-X-G motif; other site 1064539009702 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1064539009703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539009704 active site 1064539009705 phosphorylation site [posttranslational modification] 1064539009706 intermolecular recognition site; other site 1064539009707 dimerization interface [polypeptide binding]; other site 1064539009708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539009709 DNA binding site [nucleotide binding] 1064539009710 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1064539009711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064539009712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539009713 Evidence 4 : Homologs of previously reported genes of unknown function 1064539009714 Evidence 4 : Homologs of previously reported genes of unknown function 1064539009715 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1064539009716 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1064539009717 Substrate binding site; other site 1064539009718 metal-binding site 1064539009719 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 1064539009720 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539009721 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539009722 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539009723 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539009724 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1064539009725 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1064539009726 catalytic residues [active] 1064539009727 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064539009728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539009729 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1064539009730 dimerization interface [polypeptide binding]; other site 1064539009731 substrate binding pocket [chemical binding]; other site 1064539009732 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1064539009733 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1064539009734 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1064539009735 active site 1064539009736 NAD-dependent deacetylase; Provisional; Region: PRK00481 1064539009737 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1064539009738 NAD+ binding site [chemical binding]; other site 1064539009739 substrate binding site [chemical binding]; other site 1064539009740 Zn binding site [ion binding]; other site 1064539009741 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1064539009742 putative uracil binding site [chemical binding]; other site 1064539009743 putative active site [active] 1064539009744 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1064539009745 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 1064539009746 aromatic arch; other site 1064539009747 DCoH dimer interaction site [polypeptide binding]; other site 1064539009748 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1064539009749 DCoH tetramer interaction site [polypeptide binding]; other site 1064539009750 substrate binding site [chemical binding]; other site 1064539009751 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 1064539009752 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 1064539009753 dimerization interface [polypeptide binding]; other site 1064539009754 active site 1064539009755 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1064539009756 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1064539009757 Cl binding site [ion binding]; other site 1064539009758 oligomer interface [polypeptide binding]; other site 1064539009759 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 1064539009760 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1064539009761 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1064539009762 homodimer interface [polypeptide binding]; other site 1064539009763 NADP binding site [chemical binding]; other site 1064539009764 substrate binding site [chemical binding]; other site 1064539009765 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 1064539009766 YGGT family; Region: YGGT; pfam02325 1064539009767 EamA-like transporter family; Region: EamA; pfam00892 1064539009768 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064539009769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539009770 dimer interface [polypeptide binding]; other site 1064539009771 conserved gate region; other site 1064539009772 putative PBP binding loops; other site 1064539009773 ABC-ATPase subunit interface; other site 1064539009774 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064539009775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539009776 dimer interface [polypeptide binding]; other site 1064539009777 conserved gate region; other site 1064539009778 putative PBP binding loops; other site 1064539009779 ABC-ATPase subunit interface; other site 1064539009780 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1064539009781 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539009782 substrate binding pocket [chemical binding]; other site 1064539009783 membrane-bound complex binding site; other site 1064539009784 hinge residues; other site 1064539009785 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1064539009786 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064539009787 Walker A/P-loop; other site 1064539009788 ATP binding site [chemical binding]; other site 1064539009789 Q-loop/lid; other site 1064539009790 ABC transporter signature motif; other site 1064539009791 Walker B; other site 1064539009792 D-loop; other site 1064539009793 H-loop/switch region; other site 1064539009794 putative transporter; Validated; Region: PRK03818 1064539009795 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1064539009796 TrkA-C domain; Region: TrkA_C; pfam02080 1064539009797 TrkA-C domain; Region: TrkA_C; pfam02080 1064539009798 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1064539009799 putative transporter; Validated; Region: PRK03818 1064539009800 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1064539009801 TrkA-C domain; Region: TrkA_C; pfam02080 1064539009802 TrkA-C domain; Region: TrkA_C; pfam02080 1064539009803 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1064539009804 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1064539009805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539009806 Walker A/P-loop; other site 1064539009807 ATP binding site [chemical binding]; other site 1064539009808 Q-loop/lid; other site 1064539009809 ABC transporter signature motif; other site 1064539009810 Walker B; other site 1064539009811 D-loop; other site 1064539009812 H-loop/switch region; other site 1064539009813 CcmB protein; Region: CcmB; pfam03379 1064539009814 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1064539009815 homotetrameric interface [polypeptide binding]; other site 1064539009816 putative active site [active] 1064539009817 metal binding site [ion binding]; metal-binding site 1064539009818 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1064539009819 heme exporter protein CcmC; Region: ccmC; TIGR01191 1064539009820 Heme exporter protein D (CcmD); Region: CcmD; cl11475 1064539009821 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1064539009822 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1064539009823 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1064539009824 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1064539009825 catalytic residues [active] 1064539009826 central insert; other site 1064539009827 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1064539009828 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1064539009829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539009830 TPR motif; other site 1064539009831 binding surface 1064539009832 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539009833 EamA-like transporter family; Region: EamA; pfam00892 1064539009834 EamA-like transporter family; Region: EamA; cl17759 1064539009835 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1064539009836 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 1064539009837 active site 1064539009838 catalytic residue [active] 1064539009839 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1064539009840 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064539009841 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1064539009842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539009843 dimerization interface [polypeptide binding]; other site 1064539009844 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539009845 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539009846 dimer interface [polypeptide binding]; other site 1064539009847 putative CheW interface [polypeptide binding]; other site 1064539009848 argininosuccinate synthase; Provisional; Region: PRK13820 1064539009849 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1064539009850 ANP binding site [chemical binding]; other site 1064539009851 Substrate Binding Site II [chemical binding]; other site 1064539009852 Substrate Binding Site I [chemical binding]; other site 1064539009853 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1064539009854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539009855 FeS/SAM binding site; other site 1064539009856 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1064539009857 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539009858 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539009859 DNA binding residues [nucleotide binding] 1064539009860 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 1064539009861 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1064539009862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539009863 S-adenosylmethionine binding site [chemical binding]; other site 1064539009864 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1064539009865 L-asparaginase II; Region: Asparaginase_II; pfam06089 1064539009866 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064539009867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539009868 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1064539009869 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1064539009870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539009871 S-adenosylmethionine binding site [chemical binding]; other site 1064539009872 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1064539009873 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1064539009874 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1064539009875 ligand binding site; other site 1064539009876 oligomer interface; other site 1064539009877 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1064539009878 dimer interface [polypeptide binding]; other site 1064539009879 N-terminal domain interface [polypeptide binding]; other site 1064539009880 sulfate 1 binding site; other site 1064539009881 glycogen synthase; Provisional; Region: glgA; PRK00654 1064539009882 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1064539009883 ADP-binding pocket [chemical binding]; other site 1064539009884 homodimer interface [polypeptide binding]; other site 1064539009885 GTP-binding protein LepA; Provisional; Region: PRK05433 1064539009886 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1064539009887 G1 box; other site 1064539009888 putative GEF interaction site [polypeptide binding]; other site 1064539009889 GTP/Mg2+ binding site [chemical binding]; other site 1064539009890 Switch I region; other site 1064539009891 G2 box; other site 1064539009892 G3 box; other site 1064539009893 Switch II region; other site 1064539009894 G4 box; other site 1064539009895 G5 box; other site 1064539009896 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1064539009897 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1064539009898 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1064539009899 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1064539009900 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539009901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539009902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064539009903 dimerization interface [polypeptide binding]; other site 1064539009904 Bacterial SH3 domain; Region: SH3_3; cl17532 1064539009905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539009906 active site 1064539009907 phosphorylation site [posttranslational modification] 1064539009908 intermolecular recognition site; other site 1064539009909 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1064539009910 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1064539009911 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064539009912 Zn2+ binding site [ion binding]; other site 1064539009913 Mg2+ binding site [ion binding]; other site 1064539009914 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539009915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539009916 active site 1064539009917 phosphorylation site [posttranslational modification] 1064539009918 intermolecular recognition site; other site 1064539009919 dimerization interface [polypeptide binding]; other site 1064539009920 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539009921 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539009922 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1064539009923 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1064539009924 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1064539009925 dimer interface [polypeptide binding]; other site 1064539009926 motif 1; other site 1064539009927 active site 1064539009928 motif 2; other site 1064539009929 motif 3; other site 1064539009930 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1064539009931 23S rRNA binding site [nucleotide binding]; other site 1064539009932 L21 binding site [polypeptide binding]; other site 1064539009933 L13 binding site [polypeptide binding]; other site 1064539009934 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1064539009935 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1064539009936 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 1064539009937 Peptidase family M48; Region: Peptidase_M48; pfam01435 1064539009938 HAMP domain; Region: HAMP; pfam00672 1064539009939 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1064539009940 cyclase homology domain; Region: CHD; cd07302 1064539009941 nucleotidyl binding site; other site 1064539009942 metal binding site [ion binding]; metal-binding site 1064539009943 dimer interface [polypeptide binding]; other site 1064539009944 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 1064539009945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539009946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539009947 DNA binding residues [nucleotide binding] 1064539009948 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1064539009949 active site 1064539009950 metal binding site [ion binding]; metal-binding site 1064539009951 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1064539009952 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1064539009953 4Fe-4S binding domain; Region: Fer4; cl02805 1064539009954 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1064539009955 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 1064539009956 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 1064539009957 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1064539009958 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539009959 Protein of unknown function (DUF938); Region: DUF938; pfam06080 1064539009960 FOG: CBS domain [General function prediction only]; Region: COG0517 1064539009961 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1064539009962 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1064539009963 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064539009964 RNA binding surface [nucleotide binding]; other site 1064539009965 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539009966 nucleotide binding region [chemical binding]; other site 1064539009967 ATP-binding site [chemical binding]; other site 1064539009968 heat shock protein 90; Provisional; Region: PRK05218 1064539009969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539009970 ATP binding site [chemical binding]; other site 1064539009971 Mg2+ binding site [ion binding]; other site 1064539009972 G-X-G motif; other site 1064539009973 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1064539009974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539009975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539009976 dimer interface [polypeptide binding]; other site 1064539009977 phosphorylation site [posttranslational modification] 1064539009978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539009979 ATP binding site [chemical binding]; other site 1064539009980 Mg2+ binding site [ion binding]; other site 1064539009981 G-X-G motif; other site 1064539009982 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1064539009983 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1064539009984 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1064539009985 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1064539009986 metal binding site 2 [ion binding]; metal-binding site 1064539009987 putative DNA binding helix; other site 1064539009988 metal binding site 1 [ion binding]; metal-binding site 1064539009989 dimer interface [polypeptide binding]; other site 1064539009990 structural Zn2+ binding site [ion binding]; other site 1064539009991 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1064539009992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539009993 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1064539009994 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1064539009995 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1064539009996 intersubunit interface [polypeptide binding]; other site 1064539009997 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1064539009998 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1064539009999 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1064539010000 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1064539010001 ABC-ATPase subunit interface; other site 1064539010002 dimer interface [polypeptide binding]; other site 1064539010003 putative PBP binding regions; other site 1064539010004 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1064539010005 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1064539010006 ABC-ATPase subunit interface; other site 1064539010007 dimer interface [polypeptide binding]; other site 1064539010008 putative PBP binding regions; other site 1064539010009 PAS fold; Region: PAS_7; pfam12860 1064539010010 PAS fold; Region: PAS_7; pfam12860 1064539010011 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539010012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539010013 putative active site [active] 1064539010014 heme pocket [chemical binding]; other site 1064539010015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539010016 dimer interface [polypeptide binding]; other site 1064539010017 phosphorylation site [posttranslational modification] 1064539010018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539010019 ATP binding site [chemical binding]; other site 1064539010020 Mg2+ binding site [ion binding]; other site 1064539010021 G-X-G motif; other site 1064539010022 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539010023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539010024 active site 1064539010025 phosphorylation site [posttranslational modification] 1064539010026 intermolecular recognition site; other site 1064539010027 dimerization interface [polypeptide binding]; other site 1064539010028 Hpt domain; Region: Hpt; pfam01627 1064539010029 putative binding surface; other site 1064539010030 active site 1064539010031 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539010032 DNA-binding site [nucleotide binding]; DNA binding site 1064539010033 RNA-binding motif; other site 1064539010034 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1064539010035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539010036 active site 1064539010037 phosphorylation site [posttranslational modification] 1064539010038 intermolecular recognition site; other site 1064539010039 dimerization interface [polypeptide binding]; other site 1064539010040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539010041 Walker A motif; other site 1064539010042 ATP binding site [chemical binding]; other site 1064539010043 Walker B motif; other site 1064539010044 arginine finger; other site 1064539010045 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539010046 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1064539010047 Flavoprotein; Region: Flavoprotein; pfam02441 1064539010048 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1064539010049 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1064539010050 trimer interface [polypeptide binding]; other site 1064539010051 active site 1064539010052 Rrf2 family protein; Region: rrf2_super; TIGR00738 1064539010053 Transcriptional regulator; Region: Rrf2; pfam02082 1064539010054 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1064539010055 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1064539010056 dimer interface [polypeptide binding]; other site 1064539010057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539010058 catalytic residue [active] 1064539010059 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1064539010060 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1064539010061 ATP binding site [chemical binding]; other site 1064539010062 substrate interface [chemical binding]; other site 1064539010063 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1064539010064 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1064539010065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539010066 active site 1064539010067 phosphorylation site [posttranslational modification] 1064539010068 intermolecular recognition site; other site 1064539010069 dimerization interface [polypeptide binding]; other site 1064539010070 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539010071 DNA binding site [nucleotide binding] 1064539010072 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1064539010073 PhoU domain; Region: PhoU; pfam01895 1064539010074 PhoU domain; Region: PhoU; pfam01895 1064539010075 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1064539010076 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1064539010077 Walker A/P-loop; other site 1064539010078 ATP binding site [chemical binding]; other site 1064539010079 Q-loop/lid; other site 1064539010080 ABC transporter signature motif; other site 1064539010081 Walker B; other site 1064539010082 D-loop; other site 1064539010083 H-loop/switch region; other site 1064539010084 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1064539010085 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1064539010086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539010087 dimer interface [polypeptide binding]; other site 1064539010088 conserved gate region; other site 1064539010089 putative PBP binding loops; other site 1064539010090 ABC-ATPase subunit interface; other site 1064539010091 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 1064539010092 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1064539010093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539010094 dimer interface [polypeptide binding]; other site 1064539010095 conserved gate region; other site 1064539010096 putative PBP binding loops; other site 1064539010097 ABC-ATPase subunit interface; other site 1064539010098 PBP superfamily domain; Region: PBP_like_2; cl17296 1064539010099 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539010100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539010101 dimer interface [polypeptide binding]; other site 1064539010102 phosphorylation site [posttranslational modification] 1064539010103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539010104 ATP binding site [chemical binding]; other site 1064539010105 Mg2+ binding site [ion binding]; other site 1064539010106 G-X-G motif; other site 1064539010107 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1064539010108 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1064539010109 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1064539010110 putative NAD(P) binding site [chemical binding]; other site 1064539010111 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1064539010112 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539010113 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539010114 ligand binding site [chemical binding]; other site 1064539010115 flexible hinge region; other site 1064539010116 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1064539010117 putative switch regulator; other site 1064539010118 non-specific DNA interactions [nucleotide binding]; other site 1064539010119 DNA binding site [nucleotide binding] 1064539010120 sequence specific DNA binding site [nucleotide binding]; other site 1064539010121 putative cAMP binding site [chemical binding]; other site 1064539010122 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 1064539010123 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1064539010124 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1064539010125 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1064539010126 metal-binding site [ion binding] 1064539010127 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1064539010128 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1064539010129 FixH; Region: FixH; pfam05751 1064539010130 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 1064539010131 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1064539010132 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1064539010133 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1064539010134 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1064539010135 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1064539010136 Cytochrome c; Region: Cytochrom_C; pfam00034 1064539010137 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1064539010138 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1064539010139 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1064539010140 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1064539010141 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1064539010142 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1064539010143 Low-spin heme binding site [chemical binding]; other site 1064539010144 Putative water exit pathway; other site 1064539010145 Binuclear center (active site) [active] 1064539010146 Putative proton exit pathway; other site 1064539010147 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1064539010148 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1064539010149 putative RNA binding site [nucleotide binding]; other site 1064539010150 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1064539010151 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1064539010152 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1064539010153 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1064539010154 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1064539010155 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1064539010156 active site 1064539010157 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064539010158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539010159 dimer interface [polypeptide binding]; other site 1064539010160 conserved gate region; other site 1064539010161 putative PBP binding loops; other site 1064539010162 ABC-ATPase subunit interface; other site 1064539010163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539010164 dimer interface [polypeptide binding]; other site 1064539010165 putative PBP binding loops; other site 1064539010166 ABC-ATPase subunit interface; other site 1064539010167 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1064539010168 CopC domain; Region: CopC; pfam04234 1064539010169 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1064539010170 FixH; Region: FixH; pfam05751 1064539010171 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1064539010172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539010173 Walker A/P-loop; other site 1064539010174 ATP binding site [chemical binding]; other site 1064539010175 Q-loop/lid; other site 1064539010176 ABC transporter signature motif; other site 1064539010177 Walker B; other site 1064539010178 D-loop; other site 1064539010179 H-loop/switch region; other site 1064539010180 TOBE domain; Region: TOBE_2; pfam08402 1064539010181 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1064539010182 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539010183 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1064539010184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539010185 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1064539010186 Walker A motif; other site 1064539010187 ATP binding site [chemical binding]; other site 1064539010188 Walker B motif; other site 1064539010189 arginine finger; other site 1064539010190 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1064539010191 DnaA box-binding interface [nucleotide binding]; other site 1064539010192 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1064539010193 enoyl-CoA hydratase; Provisional; Region: PRK05862 1064539010194 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539010195 substrate binding site [chemical binding]; other site 1064539010196 oxyanion hole (OAH) forming residues; other site 1064539010197 trimer interface [polypeptide binding]; other site 1064539010198 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1064539010199 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1064539010200 DNA binding site [nucleotide binding] 1064539010201 catalytic residue [active] 1064539010202 H2TH interface [polypeptide binding]; other site 1064539010203 putative catalytic residues [active] 1064539010204 turnover-facilitating residue; other site 1064539010205 intercalation triad [nucleotide binding]; other site 1064539010206 8OG recognition residue [nucleotide binding]; other site 1064539010207 putative reading head residues; other site 1064539010208 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1064539010209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539010210 binding surface 1064539010211 TPR motif; other site 1064539010212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539010213 binding surface 1064539010214 TPR motif; other site 1064539010215 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539010216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539010217 TPR motif; other site 1064539010218 binding surface 1064539010219 TPR repeat; Region: TPR_11; pfam13414 1064539010220 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1064539010221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539010222 S-adenosylmethionine binding site [chemical binding]; other site 1064539010223 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1064539010224 ABC1 family; Region: ABC1; cl17513 1064539010225 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1064539010226 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1064539010227 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1064539010228 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1064539010229 dimer interface [polypeptide binding]; other site 1064539010230 substrate binding site [chemical binding]; other site 1064539010231 metal binding sites [ion binding]; metal-binding site 1064539010232 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1064539010233 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1064539010234 NAD(P) binding site [chemical binding]; other site 1064539010235 LDH/MDH dimer interface [polypeptide binding]; other site 1064539010236 substrate binding site [chemical binding]; other site 1064539010237 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1064539010238 CoA binding domain; Region: CoA_binding_2; pfam13380 1064539010239 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1064539010240 Tombusvirus P19 core protein; Region: Tombus_P19; pfam03220 1064539010241 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1064539010242 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1064539010243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539010244 Coenzyme A binding pocket [chemical binding]; other site 1064539010245 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1064539010246 putative active site [active] 1064539010247 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1064539010248 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1064539010249 dimerization interface [polypeptide binding]; other site 1064539010250 ligand binding site [chemical binding]; other site 1064539010251 NADP binding site [chemical binding]; other site 1064539010252 catalytic site [active] 1064539010253 Bacterial SH3 domain; Region: SH3_4; pfam06347 1064539010254 Bacterial SH3 domain; Region: SH3_4; pfam06347 1064539010255 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 1064539010256 Rubrerythrin [Energy production and conversion]; Region: COG1592 1064539010257 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1064539010258 binuclear metal center [ion binding]; other site 1064539010259 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1064539010260 metal binding site 2 [ion binding]; metal-binding site 1064539010261 putative DNA binding helix; other site 1064539010262 metal binding site 1 [ion binding]; metal-binding site 1064539010263 dimer interface [polypeptide binding]; other site 1064539010264 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1064539010265 FMN binding site [chemical binding]; other site 1064539010266 substrate binding site [chemical binding]; other site 1064539010267 putative catalytic residue [active] 1064539010268 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1064539010269 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1064539010270 putative active site [active] 1064539010271 catalytic site [active] 1064539010272 putative metal binding site [ion binding]; other site 1064539010273 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1064539010274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539010275 FeS/SAM binding site; other site 1064539010276 TspO/MBR family; Region: TspO_MBR; cl01379 1064539010277 Predicted metalloprotease [General function prediction only]; Region: COG2321 1064539010278 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1064539010279 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539010280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539010281 S-adenosylmethionine binding site [chemical binding]; other site 1064539010282 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1064539010283 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1064539010284 RNase E interface [polypeptide binding]; other site 1064539010285 trimer interface [polypeptide binding]; other site 1064539010286 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1064539010287 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1064539010288 RNase E interface [polypeptide binding]; other site 1064539010289 trimer interface [polypeptide binding]; other site 1064539010290 active site 1064539010291 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1064539010292 putative nucleic acid binding region [nucleotide binding]; other site 1064539010293 G-X-X-G motif; other site 1064539010294 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1064539010295 RNA binding site [nucleotide binding]; other site 1064539010296 domain interface; other site 1064539010297 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1064539010298 16S/18S rRNA binding site [nucleotide binding]; other site 1064539010299 S13e-L30e interaction site [polypeptide binding]; other site 1064539010300 25S rRNA binding site [nucleotide binding]; other site 1064539010301 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1064539010302 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1064539010303 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1064539010304 translation initiation factor IF-2; Region: IF-2; TIGR00487 1064539010305 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1064539010306 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1064539010307 G1 box; other site 1064539010308 putative GEF interaction site [polypeptide binding]; other site 1064539010309 GTP/Mg2+ binding site [chemical binding]; other site 1064539010310 Switch I region; other site 1064539010311 G2 box; other site 1064539010312 G3 box; other site 1064539010313 Switch II region; other site 1064539010314 G4 box; other site 1064539010315 G5 box; other site 1064539010316 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1064539010317 Translation-initiation factor 2; Region: IF-2; pfam11987 1064539010318 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1064539010319 hypothetical protein; Provisional; Region: PRK09190 1064539010320 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1064539010321 putative RNA binding cleft [nucleotide binding]; other site 1064539010322 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1064539010323 NusA N-terminal domain; Region: NusA_N; pfam08529 1064539010324 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1064539010325 RNA binding site [nucleotide binding]; other site 1064539010326 homodimer interface [polypeptide binding]; other site 1064539010327 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1064539010328 G-X-X-G motif; other site 1064539010329 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1064539010330 G-X-X-G motif; other site 1064539010331 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1064539010332 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1064539010333 Sm and related proteins; Region: Sm_like; cl00259 1064539010334 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1064539010335 putative oligomer interface [polypeptide binding]; other site 1064539010336 putative RNA binding site [nucleotide binding]; other site 1064539010337 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1064539010338 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1064539010339 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1064539010340 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1064539010341 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1064539010342 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1064539010343 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1064539010344 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539010345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539010346 non-specific DNA binding site [nucleotide binding]; other site 1064539010347 salt bridge; other site 1064539010348 sequence-specific DNA binding site [nucleotide binding]; other site 1064539010349 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1064539010350 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1064539010351 putative active site [active] 1064539010352 catalytic triad [active] 1064539010353 putative dimer interface [polypeptide binding]; other site 1064539010354 FOG: CBS domain [General function prediction only]; Region: COG0517 1064539010355 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1064539010356 Transporter associated domain; Region: CorC_HlyC; smart01091 1064539010357 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1064539010358 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1064539010359 PhoH-like protein; Region: PhoH; pfam02562 1064539010360 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1064539010361 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1064539010362 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539010363 FeS/SAM binding site; other site 1064539010364 TRAM domain; Region: TRAM; cl01282 1064539010365 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1064539010366 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1064539010367 putative acyl-acceptor binding pocket; other site 1064539010368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1064539010369 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1064539010370 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1064539010371 CPxP motif; other site 1064539010372 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1064539010373 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1064539010374 Glycoprotease family; Region: Peptidase_M22; pfam00814 1064539010375 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1064539010376 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 1064539010377 putative active site [active] 1064539010378 putative metal binding site [ion binding]; other site 1064539010379 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 1064539010380 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1064539010381 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1064539010382 cyclase homology domain; Region: CHD; cd07302 1064539010383 nucleotidyl binding site; other site 1064539010384 metal binding site [ion binding]; metal-binding site 1064539010385 dimer interface [polypeptide binding]; other site 1064539010386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539010387 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064539010388 Ligand Binding Site [chemical binding]; other site 1064539010389 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 1064539010390 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1064539010391 adenosine kinase; Provisional; Region: PTZ00247 1064539010392 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1064539010393 substrate binding site [chemical binding]; other site 1064539010394 ATP binding site [chemical binding]; other site 1064539010395 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1064539010396 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1064539010397 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1064539010398 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1064539010399 minor groove reading motif; other site 1064539010400 helix-hairpin-helix signature motif; other site 1064539010401 substrate binding pocket [chemical binding]; other site 1064539010402 active site 1064539010403 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1064539010404 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 1064539010405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539010406 Helix-turn-helix domain; Region: HTH_18; pfam12833 1064539010407 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1064539010408 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1064539010409 DNA binding site [nucleotide binding] 1064539010410 active site 1064539010411 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1064539010412 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1064539010413 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1064539010414 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1064539010415 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1064539010416 metal binding site [ion binding]; metal-binding site 1064539010417 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1064539010418 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1064539010419 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1064539010420 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1064539010421 putative PBP binding regions; other site 1064539010422 ABC-ATPase subunit interface; other site 1064539010423 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1064539010424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539010425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064539010426 dimerization interface [polypeptide binding]; other site 1064539010427 Lysine efflux permease [General function prediction only]; Region: COG1279 1064539010428 PAS fold; Region: PAS_3; pfam08447 1064539010429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539010430 putative active site [active] 1064539010431 heme pocket [chemical binding]; other site 1064539010432 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539010433 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539010434 dimer interface [polypeptide binding]; other site 1064539010435 putative CheW interface [polypeptide binding]; other site 1064539010436 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1064539010437 Cysteine-rich domain; Region: CCG; pfam02754 1064539010438 Cysteine-rich domain; Region: CCG; pfam02754 1064539010439 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1064539010440 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1064539010441 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1064539010442 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1064539010443 Smr domain; Region: Smr; pfam01713 1064539010444 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539010445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539010446 non-specific DNA binding site [nucleotide binding]; other site 1064539010447 salt bridge; other site 1064539010448 sequence-specific DNA binding site [nucleotide binding]; other site 1064539010449 PAS domain S-box; Region: sensory_box; TIGR00229 1064539010450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539010451 putative active site [active] 1064539010452 heme pocket [chemical binding]; other site 1064539010453 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539010454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539010455 putative active site [active] 1064539010456 heme pocket [chemical binding]; other site 1064539010457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539010458 dimer interface [polypeptide binding]; other site 1064539010459 phosphorylation site [posttranslational modification] 1064539010460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539010461 ATP binding site [chemical binding]; other site 1064539010462 Mg2+ binding site [ion binding]; other site 1064539010463 G-X-G motif; other site 1064539010464 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1064539010465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539010466 Walker A/P-loop; other site 1064539010467 ATP binding site [chemical binding]; other site 1064539010468 Q-loop/lid; other site 1064539010469 ABC transporter signature motif; other site 1064539010470 Walker B; other site 1064539010471 D-loop; other site 1064539010472 H-loop/switch region; other site 1064539010473 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064539010474 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1064539010475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539010476 Walker A motif; other site 1064539010477 ATP binding site [chemical binding]; other site 1064539010478 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1064539010479 Walker B motif; other site 1064539010480 arginine finger; other site 1064539010481 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1064539010482 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1064539010483 active site 1064539010484 HslU subunit interaction site [polypeptide binding]; other site 1064539010485 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1064539010486 putative active site pocket [active] 1064539010487 4-fold oligomerization interface [polypeptide binding]; other site 1064539010488 metal binding residues [ion binding]; metal-binding site 1064539010489 3-fold/trimer interface [polypeptide binding]; other site 1064539010490 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1064539010491 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1064539010492 putative active site [active] 1064539010493 oxyanion strand; other site 1064539010494 catalytic triad [active] 1064539010495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539010496 Coenzyme A binding pocket [chemical binding]; other site 1064539010497 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1064539010498 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1064539010499 catalytic residues [active] 1064539010500 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1064539010501 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1064539010502 substrate binding site [chemical binding]; other site 1064539010503 glutamase interaction surface [polypeptide binding]; other site 1064539010504 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1064539010505 metal binding site [ion binding]; metal-binding site 1064539010506 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1064539010507 nucleotide binding site/active site [active] 1064539010508 HIT family signature motif; other site 1064539010509 catalytic residue [active] 1064539010510 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1064539010511 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1064539010512 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1064539010513 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1064539010514 MltA specific insert domain; Region: MltA; smart00925 1064539010515 3D domain; Region: 3D; pfam06725 1064539010516 Tim44-like domain; Region: Tim44; pfam04280 1064539010517 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1064539010518 preprotein translocase subunit SecB; Validated; Region: PRK05751 1064539010519 SecA binding site; other site 1064539010520 Preprotein binding site; other site 1064539010521 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1064539010522 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1064539010523 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1064539010524 RNA binding site [nucleotide binding]; other site 1064539010525 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1064539010526 multimer interface [polypeptide binding]; other site 1064539010527 Walker A motif; other site 1064539010528 ATP binding site [chemical binding]; other site 1064539010529 Walker B motif; other site 1064539010530 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1064539010531 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1064539010532 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1064539010533 sarco/endoplasmic reticulum calcium-translocating P-type ATPase; Region: ATPase-IIA1_Ca; TIGR01116 1064539010534 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1064539010535 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1064539010536 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1064539010537 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 1064539010538 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1064539010539 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1064539010540 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1064539010541 substrate binding site [chemical binding]; other site 1064539010542 active site 1064539010543 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1064539010544 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1064539010545 active site 1064539010546 dimer interface [polypeptide binding]; other site 1064539010547 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1064539010548 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1064539010549 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1064539010550 shikimate binding site; other site 1064539010551 NAD(P) binding site [chemical binding]; other site 1064539010552 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1064539010553 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1064539010554 CoA-binding site [chemical binding]; other site 1064539010555 ATP-binding [chemical binding]; other site 1064539010556 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1064539010557 active site 1064539010558 catalytic site [active] 1064539010559 substrate binding site [chemical binding]; other site 1064539010560 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1064539010561 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1064539010562 NADP binding site [chemical binding]; other site 1064539010563 dimer interface [polypeptide binding]; other site 1064539010564 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1064539010565 DNA binding site [nucleotide binding] 1064539010566 active site 1064539010567 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1064539010568 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1064539010569 catalytic residues [active] 1064539010570 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1064539010571 dimer interface [polypeptide binding]; other site 1064539010572 [2Fe-2S] cluster binding site [ion binding]; other site 1064539010573 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1064539010574 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1064539010575 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1064539010576 G1 box; other site 1064539010577 GTP/Mg2+ binding site [chemical binding]; other site 1064539010578 Switch I region; other site 1064539010579 G2 box; other site 1064539010580 Switch II region; other site 1064539010581 G3 box; other site 1064539010582 G4 box; other site 1064539010583 G5 box; other site 1064539010584 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1064539010585 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1064539010586 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1064539010587 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1064539010588 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1064539010589 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1064539010590 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1064539010591 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539010592 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539010593 Magnesium ion binding site [ion binding]; other site 1064539010594 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1064539010595 ParB-like nuclease domain; Region: ParB; smart00470 1064539010596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1064539010597 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 1064539010598 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1064539010599 Lipopolysaccharide-assembly; Region: LptE; cl01125 1064539010600 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1064539010601 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1064539010602 HIGH motif; other site 1064539010603 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1064539010604 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1064539010605 active site 1064539010606 KMSKS motif; other site 1064539010607 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1064539010608 tRNA binding surface [nucleotide binding]; other site 1064539010609 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 1064539010610 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1064539010611 trimer interface [polypeptide binding]; other site 1064539010612 eyelet of channel; other site 1064539010613 Gram-negative porin; Region: Porin_4; pfam13609 1064539010614 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1064539010615 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064539010616 catalytic residue [active] 1064539010617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1064539010618 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1064539010619 dimerization interface [polypeptide binding]; other site 1064539010620 active site 1064539010621 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539010622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1064539010623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539010624 active site 1064539010625 phosphorylation site [posttranslational modification] 1064539010626 intermolecular recognition site; other site 1064539010627 dimerization interface [polypeptide binding]; other site 1064539010628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539010629 DNA binding site [nucleotide binding] 1064539010630 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1064539010631 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1064539010632 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1064539010633 Peptidase M15; Region: Peptidase_M15_3; cl01194 1064539010634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1064539010635 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1064539010636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539010637 dimer interface [polypeptide binding]; other site 1064539010638 conserved gate region; other site 1064539010639 putative PBP binding loops; other site 1064539010640 ABC-ATPase subunit interface; other site 1064539010641 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539010642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539010643 dimer interface [polypeptide binding]; other site 1064539010644 conserved gate region; other site 1064539010645 putative PBP binding loops; other site 1064539010646 ABC-ATPase subunit interface; other site 1064539010647 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1064539010648 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1064539010649 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1064539010650 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539010651 Walker A/P-loop; other site 1064539010652 ATP binding site [chemical binding]; other site 1064539010653 Q-loop/lid; other site 1064539010654 ABC transporter signature motif; other site 1064539010655 Walker B; other site 1064539010656 D-loop; other site 1064539010657 H-loop/switch region; other site 1064539010658 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539010659 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539010660 Walker A/P-loop; other site 1064539010661 ATP binding site [chemical binding]; other site 1064539010662 Q-loop/lid; other site 1064539010663 ABC transporter signature motif; other site 1064539010664 Walker B; other site 1064539010665 D-loop; other site 1064539010666 H-loop/switch region; other site 1064539010667 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539010668 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 1064539010669 NodB motif; other site 1064539010670 putative active site [active] 1064539010671 putative catalytic site [active] 1064539010672 putative Zn binding site [ion binding]; other site 1064539010673 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1064539010674 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1064539010675 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539010676 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539010677 ligand binding site [chemical binding]; other site 1064539010678 flexible hinge region; other site 1064539010679 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1064539010680 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539010681 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1064539010682 Walker A/P-loop; other site 1064539010683 ATP binding site [chemical binding]; other site 1064539010684 Q-loop/lid; other site 1064539010685 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1064539010686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539010687 ABC transporter signature motif; other site 1064539010688 Walker B; other site 1064539010689 D-loop; other site 1064539010690 H-loop/switch region; other site 1064539010691 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1064539010692 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1064539010693 putative ADP-binding pocket [chemical binding]; other site 1064539010694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539010695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539010696 PAS domain; Region: PAS_9; pfam13426 1064539010697 putative active site [active] 1064539010698 heme pocket [chemical binding]; other site 1064539010699 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539010700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539010701 metal binding site [ion binding]; metal-binding site 1064539010702 active site 1064539010703 I-site; other site 1064539010704 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539010705 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064539010706 catalytic core [active] 1064539010707 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1064539010708 putative catalytic site [active] 1064539010709 putative phosphate binding site [ion binding]; other site 1064539010710 active site 1064539010711 metal binding site A [ion binding]; metal-binding site 1064539010712 DNA binding site [nucleotide binding] 1064539010713 putative AP binding site [nucleotide binding]; other site 1064539010714 putative metal binding site B [ion binding]; other site 1064539010715 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1064539010716 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1064539010717 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064539010718 MarR family; Region: MarR; pfam01047 1064539010719 Peptidase C26; Region: Peptidase_C26; pfam07722 1064539010720 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1064539010721 catalytic triad [active] 1064539010722 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 1064539010723 spermidine synthase; Provisional; Region: PRK00811 1064539010724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539010725 TAP-like protein; Region: Abhydrolase_4; pfam08386 1064539010726 OpgC protein; Region: OpgC_C; cl17858 1064539010727 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1064539010728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539010729 NAD(P) binding site [chemical binding]; other site 1064539010730 active site 1064539010731 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539010732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539010733 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1064539010734 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1064539010735 trimer interface [polypeptide binding]; other site 1064539010736 active site 1064539010737 substrate binding site [chemical binding]; other site 1064539010738 CoA binding site [chemical binding]; other site 1064539010739 MarR family; Region: MarR_2; pfam12802 1064539010740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1064539010741 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1064539010742 SEC-C motif; Region: SEC-C; pfam02810 1064539010743 Flagellin N-methylase; Region: FliB; cl00497 1064539010744 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1064539010745 putative substrate binding pocket [chemical binding]; other site 1064539010746 AC domain interface; other site 1064539010747 catalytic triad [active] 1064539010748 AB domain interface; other site 1064539010749 interchain disulfide; other site 1064539010750 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1064539010751 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1064539010752 active site 1064539010753 HIGH motif; other site 1064539010754 dimer interface [polypeptide binding]; other site 1064539010755 KMSKS motif; other site 1064539010756 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1064539010757 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1064539010758 PAS domain; Region: PAS_9; pfam13426 1064539010759 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1064539010760 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539010761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539010762 dimer interface [polypeptide binding]; other site 1064539010763 phosphorylation site [posttranslational modification] 1064539010764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539010765 ATP binding site [chemical binding]; other site 1064539010766 Mg2+ binding site [ion binding]; other site 1064539010767 G-X-G motif; other site 1064539010768 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539010769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539010770 active site 1064539010771 phosphorylation site [posttranslational modification] 1064539010772 intermolecular recognition site; other site 1064539010773 dimerization interface [polypeptide binding]; other site 1064539010774 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1064539010775 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1064539010776 ligand binding site [chemical binding]; other site 1064539010777 dimerization interface [polypeptide binding]; other site 1064539010778 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 1064539010779 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1064539010780 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1064539010781 active site 1064539010782 PII uridylyl-transferase; Provisional; Region: PRK05092 1064539010783 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1064539010784 metal binding triad; other site 1064539010785 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1064539010786 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064539010787 Zn2+ binding site [ion binding]; other site 1064539010788 Mg2+ binding site [ion binding]; other site 1064539010789 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1064539010790 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1064539010791 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1064539010792 MutS domain I; Region: MutS_I; pfam01624 1064539010793 MutS domain II; Region: MutS_II; pfam05188 1064539010794 MutS domain III; Region: MutS_III; pfam05192 1064539010795 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1064539010796 Walker A/P-loop; other site 1064539010797 ATP binding site [chemical binding]; other site 1064539010798 Q-loop/lid; other site 1064539010799 ABC transporter signature motif; other site 1064539010800 Walker B; other site 1064539010801 D-loop; other site 1064539010802 H-loop/switch region; other site 1064539010803 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1064539010804 anti sigma factor interaction site; other site 1064539010805 regulatory phosphorylation site [posttranslational modification]; other site 1064539010806 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1064539010807 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1064539010808 homodimer interface [polypeptide binding]; other site 1064539010809 substrate-cofactor binding pocket; other site 1064539010810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539010811 catalytic residue [active] 1064539010812 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539010813 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1064539010814 putative ligand binding site [chemical binding]; other site 1064539010815 Predicted methyltransferases [General function prediction only]; Region: COG0313 1064539010816 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1064539010817 putative SAM binding site [chemical binding]; other site 1064539010818 putative homodimer interface [polypeptide binding]; other site 1064539010819 hypothetical protein; Reviewed; Region: PRK12497 1064539010820 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1064539010821 Tetratricopeptide repeat; Region: TPR_9; pfam13371 1064539010822 glutathione synthetase; Provisional; Region: PRK05246 1064539010823 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1064539010824 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1064539010825 Helix-turn-helix; Region: HTH_3; pfam01381 1064539010826 sequence-specific DNA binding site [nucleotide binding]; other site 1064539010827 salt bridge; other site 1064539010828 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1064539010829 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1064539010830 folate binding site [chemical binding]; other site 1064539010831 NADP+ binding site [chemical binding]; other site 1064539010832 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1064539010833 HAMP domain; Region: HAMP; pfam00672 1064539010834 dimerization interface [polypeptide binding]; other site 1064539010835 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539010836 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539010837 dimer interface [polypeptide binding]; other site 1064539010838 putative CheW interface [polypeptide binding]; other site 1064539010839 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 1064539010840 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539010841 FeS/SAM binding site; other site 1064539010842 HemN C-terminal domain; Region: HemN_C; pfam06969 1064539010843 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1064539010844 active site 1064539010845 dimerization interface [polypeptide binding]; other site 1064539010846 ribonuclease PH; Reviewed; Region: rph; PRK00173 1064539010847 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1064539010848 hexamer interface [polypeptide binding]; other site 1064539010849 active site 1064539010850 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1064539010851 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1064539010852 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1064539010853 dimer interface [polypeptide binding]; other site 1064539010854 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1064539010855 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539010856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539010857 active site 1064539010858 phosphorylation site [posttranslational modification] 1064539010859 intermolecular recognition site; other site 1064539010860 dimerization interface [polypeptide binding]; other site 1064539010861 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 1064539010862 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1064539010863 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1064539010864 nucleotide binding site [chemical binding]; other site 1064539010865 NEF interaction site [polypeptide binding]; other site 1064539010866 SBD interface [polypeptide binding]; other site 1064539010867 chaperone protein DnaJ; Provisional; Region: PRK10767 1064539010868 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1064539010869 HSP70 interaction site [polypeptide binding]; other site 1064539010870 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1064539010871 substrate binding site [polypeptide binding]; other site 1064539010872 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1064539010873 Zn binding sites [ion binding]; other site 1064539010874 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1064539010875 dimer interface [polypeptide binding]; other site 1064539010876 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539010877 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539010878 metal binding site [ion binding]; metal-binding site 1064539010879 active site 1064539010880 I-site; other site 1064539010881 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1064539010882 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1064539010883 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1064539010884 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1064539010885 Walker A/P-loop; other site 1064539010886 ATP binding site [chemical binding]; other site 1064539010887 Q-loop/lid; other site 1064539010888 ABC transporter signature motif; other site 1064539010889 Walker B; other site 1064539010890 D-loop; other site 1064539010891 H-loop/switch region; other site 1064539010892 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1064539010893 active site 1064539010894 catalytic triad [active] 1064539010895 oxyanion hole [active] 1064539010896 switch loop; other site 1064539010897 FIST N domain; Region: FIST; pfam08495 1064539010898 FIST C domain; Region: FIST_C; pfam10442 1064539010899 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064539010900 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064539010901 active site 1064539010902 catalytic tetrad [active] 1064539010903 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1064539010904 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1064539010905 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1064539010906 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1064539010907 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1064539010908 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1064539010909 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1064539010910 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1064539010911 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539010912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539010913 homodimer interface [polypeptide binding]; other site 1064539010914 catalytic residue [active] 1064539010915 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1064539010916 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1064539010917 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1064539010918 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1064539010919 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1064539010920 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1064539010921 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1064539010922 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1064539010923 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1064539010924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539010925 Walker A motif; other site 1064539010926 ATP binding site [chemical binding]; other site 1064539010927 Walker B motif; other site 1064539010928 arginine finger; other site 1064539010929 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1064539010930 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1064539010931 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064539010932 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1064539010933 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539010934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539010935 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539010936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539010937 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1064539010938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539010939 ABC-ATPase subunit interface; other site 1064539010940 putative PBP binding loops; other site 1064539010941 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064539010942 active site 1064539010943 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1064539010944 Domain of unknown function (DUF892); Region: DUF892; pfam05974 1064539010945 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1064539010946 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1064539010947 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1064539010948 diiron binding motif [ion binding]; other site 1064539010949 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1064539010950 TPP-binding site [chemical binding]; other site 1064539010951 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1064539010952 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 1064539010953 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1064539010954 dimer interface [polypeptide binding]; other site 1064539010955 PYR/PP interface [polypeptide binding]; other site 1064539010956 TPP binding site [chemical binding]; other site 1064539010957 substrate binding site [chemical binding]; other site 1064539010958 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064539010959 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1064539010960 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1064539010961 Moco binding site; other site 1064539010962 metal coordination site [ion binding]; other site 1064539010963 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539010964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539010965 dimer interface [polypeptide binding]; other site 1064539010966 phosphorylation site [posttranslational modification] 1064539010967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539010968 ATP binding site [chemical binding]; other site 1064539010969 Mg2+ binding site [ion binding]; other site 1064539010970 G-X-G motif; other site 1064539010971 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1064539010972 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1064539010973 conserved cys residue [active] 1064539010974 isocitrate lyase; Provisional; Region: PRK15063 1064539010975 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1064539010976 tetramer interface [polypeptide binding]; other site 1064539010977 active site 1064539010978 Mg2+/Mn2+ binding site [ion binding]; other site 1064539010979 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539010980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539010981 non-specific DNA binding site [nucleotide binding]; other site 1064539010982 salt bridge; other site 1064539010983 sequence-specific DNA binding site [nucleotide binding]; other site 1064539010984 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1064539010985 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1064539010986 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1064539010987 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1064539010988 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1064539010989 FAD binding pocket [chemical binding]; other site 1064539010990 FAD binding motif [chemical binding]; other site 1064539010991 phosphate binding motif [ion binding]; other site 1064539010992 beta-alpha-beta structure motif; other site 1064539010993 NAD binding pocket [chemical binding]; other site 1064539010994 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1064539010995 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064539010996 active site 1064539010997 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11123673; Product type pr : putative regulator 1064539010998 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11123673; Product type pr : putative regulator 1064539010999 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1064539011000 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064539011001 potential frameshift: common BLAST hit: gi|375006509|ref|YP_004975293.1| Putative oligopeptide ABC transporter, ATPase component 1064539011002 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539011003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539011004 Walker A/P-loop; other site 1064539011005 ATP binding site [chemical binding]; other site 1064539011006 Q-loop/lid; other site 1064539011007 ABC transporter signature motif; other site 1064539011008 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1064539011009 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1064539011010 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1064539011011 putative active site [active] 1064539011012 putative active site [active] 1064539011013 catalytic site [active] 1064539011014 catalytic site [active] 1064539011015 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1064539011016 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1064539011017 putative active site [active] 1064539011018 putative active site [active] 1064539011019 catalytic site [active] 1064539011020 catalytic site [active] 1064539011021 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1064539011022 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1064539011023 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1064539011024 putative catalytic site [active] 1064539011025 putative metal binding site [ion binding]; other site 1064539011026 putative phosphate binding site [ion binding]; other site 1064539011027 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 1064539011028 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1064539011029 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1064539011030 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1064539011031 potential frameshift: common BLAST hit: gi|114331188|ref|YP_747410.1| FAD-dependent pyridine nucleotide-disulfide oxidoreductase 1064539011032 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 1064539011033 potential frameshift: common BLAST hit: gi|325981345|ref|YP_004293747.1| FAD-dependent pyridine nucleotide-disulfide oxidoreductase 1064539011034 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 1064539011035 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 1064539011036 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 1064539011037 FAD binding pocket [chemical binding]; other site 1064539011038 FAD binding motif [chemical binding]; other site 1064539011039 phosphate binding motif [ion binding]; other site 1064539011040 beta-alpha-beta structure motif; other site 1064539011041 NAD binding pocket [chemical binding]; other site 1064539011042 Iron coordination center [ion binding]; other site 1064539011043 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1064539011044 catalytic residues [active] 1064539011045 Usg-like family; Region: Usg; cl11567 1064539011046 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1064539011047 oligomerisation interface [polypeptide binding]; other site 1064539011048 mobile loop; other site 1064539011049 roof hairpin; other site 1064539011050 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1064539011051 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1064539011052 ring oligomerisation interface [polypeptide binding]; other site 1064539011053 ATP/Mg binding site [chemical binding]; other site 1064539011054 stacking interactions; other site 1064539011055 hinge regions; other site 1064539011056 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1064539011057 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1064539011058 tetramer interface [polypeptide binding]; other site 1064539011059 heme binding pocket [chemical binding]; other site 1064539011060 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1064539011061 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1064539011062 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1064539011063 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1064539011064 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1064539011065 Transglycosylase; Region: Transgly; pfam00912 1064539011066 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1064539011067 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1064539011068 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 1064539011069 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1064539011070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539011071 Walker A motif; other site 1064539011072 ATP binding site [chemical binding]; other site 1064539011073 Walker B motif; other site 1064539011074 arginine finger; other site 1064539011075 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1064539011076 phage shock protein A; Region: phageshock_pspA; TIGR02977 1064539011077 Phage shock protein B; Region: PspB; pfam06667 1064539011078 phage shock protein C; Region: phageshock_pspC; TIGR02978 1064539011079 PspC domain; Region: PspC; pfam04024 1064539011080 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539011081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1064539011082 active site 1064539011083 phosphorylation site [posttranslational modification] 1064539011084 intermolecular recognition site; other site 1064539011085 dimerization interface [polypeptide binding]; other site 1064539011086 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1064539011087 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539011088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539011089 metal binding site [ion binding]; metal-binding site 1064539011090 active site 1064539011091 I-site; other site 1064539011092 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1064539011093 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1064539011094 active site 1064539011095 potential protein location (conserved protein of unknown function [Azospirillum brasilense Sp245]) that overlaps RNA (ribosomal RNA 16s ribosomal RNA) 1064539011096 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539011097 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1064539011098 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539011099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539011100 metal binding site [ion binding]; metal-binding site 1064539011101 active site 1064539011102 I-site; other site 1064539011103 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1064539011104 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1064539011105 Walker A motif; other site 1064539011106 ATP binding site [chemical binding]; other site 1064539011107 Walker B motif; other site 1064539011108 TPR repeat; Region: TPR_11; pfam13414 1064539011109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539011110 TPR motif; other site 1064539011111 binding surface 1064539011112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539011113 TPR motif; other site 1064539011114 binding surface 1064539011115 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064539011116 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1064539011117 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539011118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539011119 dimer interface [polypeptide binding]; other site 1064539011120 conserved gate region; other site 1064539011121 putative PBP binding loops; other site 1064539011122 ABC-ATPase subunit interface; other site 1064539011123 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1064539011124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539011125 dimer interface [polypeptide binding]; other site 1064539011126 conserved gate region; other site 1064539011127 ABC-ATPase subunit interface; other site 1064539011128 Evidence 2b : Function of strongly homologous gene; PubMedId : 7536291; Product type t : transporter 1064539011129 Evidence 2b : Function of strongly homologous gene; PubMedId : 7536291; Product type t : transporter 1064539011130 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1064539011131 MarR family; Region: MarR_2; pfam12802 1064539011132 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539011133 EamA-like transporter family; Region: EamA; pfam00892 1064539011134 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1064539011135 active site 1064539011136 metal binding site [ion binding]; metal-binding site 1064539011137 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 1064539011138 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539011139 DNA-binding site [nucleotide binding]; DNA binding site 1064539011140 RNA-binding motif; other site 1064539011141 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539011142 DNA-binding site [nucleotide binding]; DNA binding site 1064539011143 RNA-binding motif; other site 1064539011144 phosphoglucomutase; Region: PLN02307 1064539011145 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1064539011146 active site 1064539011147 substrate binding site [chemical binding]; other site 1064539011148 metal binding site [ion binding]; metal-binding site 1064539011149 Dienelactone hydrolase family; Region: DLH; pfam01738 1064539011150 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1064539011151 SelR domain; Region: SelR; pfam01641 1064539011152 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1064539011153 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1064539011154 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1064539011155 anti sigma factor interaction site; other site 1064539011156 regulatory phosphorylation site [posttranslational modification]; other site 1064539011157 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 1064539011158 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1064539011159 ligand binding site [chemical binding]; other site 1064539011160 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1064539011161 G1 box; other site 1064539011162 GTP/Mg2+ binding site [chemical binding]; other site 1064539011163 G2 box; other site 1064539011164 G3 box; other site 1064539011165 Switch II region; other site 1064539011166 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1064539011167 G4 box; other site 1064539011168 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1064539011169 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1064539011170 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1064539011171 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064539011172 ligand binding site [chemical binding]; other site 1064539011173 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539011174 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539011175 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1064539011176 DctM-like transporters; Region: DctM; pfam06808 1064539011177 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1064539011178 EamA-like transporter family; Region: EamA; pfam00892 1064539011179 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1064539011180 EamA-like transporter family; Region: EamA; pfam00892 1064539011181 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539011182 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1064539011183 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1064539011184 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539011185 AAA domain; Region: AAA_13; pfam13166 1064539011186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539011187 ABC transporter signature motif; other site 1064539011188 Walker B; other site 1064539011189 D-loop; other site 1064539011190 H-loop/switch region; other site 1064539011191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539011192 active site 1064539011193 phosphorylation site [posttranslational modification] 1064539011194 intermolecular recognition site; other site 1064539011195 dimerization interface [polypeptide binding]; other site 1064539011196 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539011197 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539011198 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1064539011199 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 1064539011200 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1064539011201 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539011202 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1064539011203 Domain of unknown function DUF29; Region: DUF29; pfam01724 1064539011204 Helix-turn-helix domain; Region: HTH_17; cl17695 1064539011205 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064539011206 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1064539011207 active site 1064539011208 catalytic residues [active] 1064539011209 DNA binding site [nucleotide binding] 1064539011210 Int/Topo IB signature motif; other site 1064539011211 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1064539011212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064539011213 ATP binding site [chemical binding]; other site 1064539011214 putative Mg++ binding site [ion binding]; other site 1064539011215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539011216 nucleotide binding region [chemical binding]; other site 1064539011217 ATP-binding site [chemical binding]; other site 1064539011218 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1064539011219 HRDC domain; Region: HRDC; pfam00570 1064539011220 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1064539011221 active site 1064539011222 8-oxo-dGMP binding site [chemical binding]; other site 1064539011223 nudix motif; other site 1064539011224 metal binding site [ion binding]; metal-binding site 1064539011225 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1064539011226 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1064539011227 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1064539011228 heterotetramer interface [polypeptide binding]; other site 1064539011229 active site pocket [active] 1064539011230 cleavage site 1064539011231 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1064539011232 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1064539011233 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1064539011234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1064539011235 nucleotide binding region [chemical binding]; other site 1064539011236 SEC-C motif; Region: SEC-C; pfam02810 1064539011237 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1064539011238 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1064539011239 helicase 45; Provisional; Region: PTZ00424 1064539011240 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1064539011241 ATP binding site [chemical binding]; other site 1064539011242 Mg++ binding site [ion binding]; other site 1064539011243 motif III; other site 1064539011244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539011245 nucleotide binding region [chemical binding]; other site 1064539011246 ATP-binding site [chemical binding]; other site 1064539011247 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1064539011248 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1064539011249 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1064539011250 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1064539011251 Family description; Region: DsbD_2; pfam13386 1064539011252 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539011253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539011254 S-adenosylmethionine binding site [chemical binding]; other site 1064539011255 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1064539011256 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1064539011257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064539011258 active site 1064539011259 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1064539011260 GSH binding site [chemical binding]; other site 1064539011261 catalytic residues [active] 1064539011262 nitrilase; Region: PLN02798 1064539011263 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1064539011264 putative active site [active] 1064539011265 catalytic triad [active] 1064539011266 dimer interface [polypeptide binding]; other site 1064539011267 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539011268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539011269 S-adenosylmethionine binding site [chemical binding]; other site 1064539011270 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 1064539011271 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1064539011272 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1064539011273 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1064539011274 Na binding site [ion binding]; other site 1064539011275 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1064539011276 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539011277 ligand binding site [chemical binding]; other site 1064539011278 flexible hinge region; other site 1064539011279 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 1064539011280 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1064539011281 metal binding triad; other site 1064539011282 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1064539011283 active site 1064539011284 catalytic site [active] 1064539011285 substrate binding site [chemical binding]; other site 1064539011286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1064539011287 Histidine kinase; Region: HisKA_2; pfam07568 1064539011288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539011289 ATP binding site [chemical binding]; other site 1064539011290 Mg2+ binding site [ion binding]; other site 1064539011291 G-X-G motif; other site 1064539011292 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1064539011293 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1064539011294 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1064539011295 active site 1064539011296 catalytic site [active] 1064539011297 substrate binding site [chemical binding]; other site 1064539011298 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1064539011299 ADP-ribose binding site [chemical binding]; other site 1064539011300 dimer interface [polypeptide binding]; other site 1064539011301 active site 1064539011302 nudix motif; other site 1064539011303 metal binding site [ion binding]; metal-binding site 1064539011304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539011305 S-adenosylmethionine binding site [chemical binding]; other site 1064539011306 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1064539011307 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539011308 putative ligand binding site [chemical binding]; other site 1064539011309 aconitate hydratase; Validated; Region: PRK09277 1064539011310 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1064539011311 substrate binding site [chemical binding]; other site 1064539011312 ligand binding site [chemical binding]; other site 1064539011313 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1064539011314 substrate binding site [chemical binding]; other site 1064539011315 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1064539011316 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1064539011317 LytTr DNA-binding domain; Region: LytTR; smart00850 1064539011318 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 1064539011319 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 1064539011320 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1064539011321 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1064539011322 putative dimer interface [polypeptide binding]; other site 1064539011323 GtrA-like protein; Region: GtrA; pfam04138 1064539011324 Predicted membrane protein [Function unknown]; Region: COG2246 1064539011325 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1064539011326 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1064539011327 Ligand binding site; other site 1064539011328 Putative Catalytic site; other site 1064539011329 DXD motif; other site 1064539011330 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1064539011331 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539011332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539011333 putative active site [active] 1064539011334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539011335 heme pocket [chemical binding]; other site 1064539011336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539011337 dimer interface [polypeptide binding]; other site 1064539011338 phosphorylation site [posttranslational modification] 1064539011339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539011340 ATP binding site [chemical binding]; other site 1064539011341 Mg2+ binding site [ion binding]; other site 1064539011342 G-X-G motif; other site 1064539011343 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539011344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539011345 active site 1064539011346 phosphorylation site [posttranslational modification] 1064539011347 intermolecular recognition site; other site 1064539011348 dimerization interface [polypeptide binding]; other site 1064539011349 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539011350 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539011351 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539011352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539011353 active site 1064539011354 phosphorylation site [posttranslational modification] 1064539011355 intermolecular recognition site; other site 1064539011356 dimerization interface [polypeptide binding]; other site 1064539011357 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539011358 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539011359 metal binding site [ion binding]; metal-binding site 1064539011360 active site 1064539011361 I-site; other site 1064539011362 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1064539011363 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1064539011364 MPT binding site; other site 1064539011365 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 1064539011366 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1064539011367 dimer interface [polypeptide binding]; other site 1064539011368 putative functional site; other site 1064539011369 putative MPT binding site; other site 1064539011370 PBP superfamily domain; Region: PBP_like; pfam12727 1064539011371 Pirin-related protein [General function prediction only]; Region: COG1741 1064539011372 Pirin; Region: Pirin; pfam02678 1064539011373 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1064539011374 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 1064539011375 TIGR02300 family protein; Region: FYDLN_acid 1064539011376 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1064539011377 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1064539011378 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1064539011379 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1064539011380 hinge; other site 1064539011381 active site 1064539011382 cytidylate kinase; Provisional; Region: cmk; PRK00023 1064539011383 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1064539011384 CMP-binding site; other site 1064539011385 The sites determining sugar specificity; other site 1064539011386 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1064539011387 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1064539011388 RNA binding site [nucleotide binding]; other site 1064539011389 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1064539011390 RNA binding site [nucleotide binding]; other site 1064539011391 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1064539011392 RNA binding site [nucleotide binding]; other site 1064539011393 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1064539011394 RNA binding site [nucleotide binding]; other site 1064539011395 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1064539011396 RNA binding site [nucleotide binding]; other site 1064539011397 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1064539011398 RNA binding site [nucleotide binding]; other site 1064539011399 Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955 1064539011400 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1064539011401 IHF dimer interface [polypeptide binding]; other site 1064539011402 IHF - DNA interface [nucleotide binding]; other site 1064539011403 ornithine cyclodeaminase; Validated; Region: PRK06141 1064539011404 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1064539011405 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1064539011406 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1064539011407 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1064539011408 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1064539011409 active site 1064539011410 dimer interface [polypeptide binding]; other site 1064539011411 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1064539011412 active site 1064539011413 diguanylate cyclase; Provisional; Region: PRK09894 1064539011414 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1064539011415 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539011416 metal binding site [ion binding]; metal-binding site 1064539011417 active site 1064539011418 I-site; other site 1064539011419 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064539011420 active site 1064539011421 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1064539011422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539011423 dimer interface [polypeptide binding]; other site 1064539011424 conserved gate region; other site 1064539011425 putative PBP binding loops; other site 1064539011426 ABC-ATPase subunit interface; other site 1064539011427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539011428 Pirin-related protein [General function prediction only]; Region: COG1741 1064539011429 Pirin; Region: Pirin; pfam02678 1064539011430 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1064539011431 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1064539011432 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064539011433 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1917840; Product type e : enzyme 1064539011434 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1917840; Product type e : enzyme 1064539011435 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1064539011436 putative active site [active] 1064539011437 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1064539011438 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 1064539011439 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 1064539011440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1064539011441 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1064539011442 HSP70 interaction site [polypeptide binding]; other site 1064539011443 BolA-like protein; Region: BolA; pfam01722 1064539011444 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1064539011445 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 1064539011446 FOG: CBS domain [General function prediction only]; Region: COG0517 1064539011447 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1064539011448 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 1064539011449 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 1064539011450 Evidence 5 : No homology to any previously reported sequences 1064539011451 Evidence 5 : No homology to any previously reported sequences 1064539011452 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1064539011453 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064539011454 active site 1064539011455 DNA binding site [nucleotide binding] 1064539011456 Int/Topo IB signature motif; other site 1064539011457 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1064539011458 malate synthase A; Region: malate_syn_A; TIGR01344 1064539011459 active site 1064539011460 Domain of unknown function DUF29; Region: DUF29; pfam01724 1064539011461 EamA-like transporter family; Region: EamA; pfam00892 1064539011462 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1064539011463 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1064539011464 MAPEG family; Region: MAPEG; pfam01124 1064539011465 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8314774; Product type pt : putative transporter 1064539011466 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8314774; Product type pt : putative transporter 1064539011467 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1064539011468 feedback inhibition sensing region; other site 1064539011469 homohexameric interface [polypeptide binding]; other site 1064539011470 nucleotide binding site [chemical binding]; other site 1064539011471 N-acetyl-L-glutamate binding site [chemical binding]; other site 1064539011472 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1064539011473 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1064539011474 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1064539011475 G1 box; other site 1064539011476 GTP/Mg2+ binding site [chemical binding]; other site 1064539011477 Switch I region; other site 1064539011478 G2 box; other site 1064539011479 G3 box; other site 1064539011480 Switch II region; other site 1064539011481 G4 box; other site 1064539011482 G5 box; other site 1064539011483 membrane protein insertase; Provisional; Region: PRK01318 1064539011484 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1064539011485 Haemolytic domain; Region: Haemolytic; pfam01809 1064539011486 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1064539011487 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1064539011488 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1064539011489 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1064539011490 active site 1064539011491 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1064539011492 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539011493 active site 1064539011494 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539011495 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1064539011496 dinuclear metal binding motif [ion binding]; other site 1064539011497 potential frameshift: common BLAST hit: gi|288962323|ref|YP_003452618.1| glycosyl transferase 1064539011498 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539011499 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539011500 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539011501 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1064539011502 putative glycosyl transferase; Provisional; Region: PRK10307 1064539011503 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1064539011504 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1064539011505 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1064539011506 NADP binding site [chemical binding]; other site 1064539011507 active site 1064539011508 putative substrate binding site [chemical binding]; other site 1064539011509 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539011510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539011511 NAD(P) binding site [chemical binding]; other site 1064539011512 active site 1064539011513 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1064539011514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539011515 NAD(P) binding site [chemical binding]; other site 1064539011516 active site 1064539011517 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1064539011518 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1064539011519 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1064539011520 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1064539011521 Chain length determinant protein; Region: Wzz; pfam02706 1064539011522 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 1064539011523 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1064539011524 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539011525 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1064539011526 ligand binding site [chemical binding]; other site 1064539011527 flexible hinge region; other site 1064539011528 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1064539011529 putative switch regulator; other site 1064539011530 non-specific DNA interactions [nucleotide binding]; other site 1064539011531 DNA binding site [nucleotide binding] 1064539011532 sequence specific DNA binding site [nucleotide binding]; other site 1064539011533 putative cAMP binding site [chemical binding]; other site 1064539011534 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1064539011535 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064539011536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539011537 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1064539011538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539011539 active site 1064539011540 phosphorylation site [posttranslational modification] 1064539011541 intermolecular recognition site; other site 1064539011542 dimerization interface [polypeptide binding]; other site 1064539011543 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1064539011544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539011545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539011546 ATP binding site [chemical binding]; other site 1064539011547 Mg2+ binding site [ion binding]; other site 1064539011548 G-X-G motif; other site 1064539011549 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1064539011550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539011551 Walker A/P-loop; other site 1064539011552 ATP binding site [chemical binding]; other site 1064539011553 Q-loop/lid; other site 1064539011554 ABC transporter signature motif; other site 1064539011555 Walker B; other site 1064539011556 D-loop; other site 1064539011557 H-loop/switch region; other site 1064539011558 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1064539011559 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064539011560 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 1064539011561 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1064539011562 trimer interface [polypeptide binding]; other site 1064539011563 active site 1064539011564 UDP-GlcNAc binding site [chemical binding]; other site 1064539011565 lipid binding site [chemical binding]; lipid-binding site 1064539011566 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1064539011567 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1064539011568 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 1064539011569 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064539011570 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1064539011571 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1064539011572 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1064539011573 putative dimer interface [polypeptide binding]; other site 1064539011574 active site pocket [active] 1064539011575 putative cataytic base [active] 1064539011576 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1064539011577 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1064539011578 metal binding site [ion binding]; metal-binding site 1064539011579 dimer interface [polypeptide binding]; other site 1064539011580 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1064539011581 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1064539011582 trimer interface [polypeptide binding]; other site 1064539011583 active site 1064539011584 substrate binding site [chemical binding]; other site 1064539011585 CoA binding site [chemical binding]; other site 1064539011586 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1064539011587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539011588 motif II; other site 1064539011589 PAS domain; Region: PAS; smart00091 1064539011590 PAS domain; Region: PAS_9; pfam13426 1064539011591 putative active site [active] 1064539011592 heme pocket [chemical binding]; other site 1064539011593 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1064539011594 GAF domain; Region: GAF_3; pfam13492 1064539011595 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539011596 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539011597 metal binding site [ion binding]; metal-binding site 1064539011598 active site 1064539011599 I-site; other site 1064539011600 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1064539011601 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1064539011602 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539011603 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539011604 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1064539011605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539011606 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539011607 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539011608 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539011609 signal recognition particle protein; Provisional; Region: PRK10867 1064539011610 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1064539011611 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1064539011612 P loop; other site 1064539011613 GTP binding site [chemical binding]; other site 1064539011614 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1064539011615 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1064539011616 RimM N-terminal domain; Region: RimM; pfam01782 1064539011617 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 1064539011618 PRC-barrel domain; Region: PRC; pfam05239 1064539011619 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1064539011620 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1064539011621 EamA-like transporter family; Region: EamA; pfam00892 1064539011622 EamA-like transporter family; Region: EamA; pfam00892 1064539011623 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1064539011624 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1064539011625 substrate binding site [chemical binding]; other site 1064539011626 ligand binding site [chemical binding]; other site 1064539011627 WYL domain; Region: WYL; pfam13280 1064539011628 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 1064539011629 putative dimer interface [polypeptide binding]; other site 1064539011630 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064539011631 hypothetical protein; Provisional; Region: PRK02268 1064539011632 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539011633 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539011634 TM-ABC transporter signature motif; other site 1064539011635 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1064539011636 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1064539011637 dimerization interface 3.5A [polypeptide binding]; other site 1064539011638 active site 1064539011639 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1064539011640 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1064539011641 putative active site [active] 1064539011642 substrate binding site [chemical binding]; other site 1064539011643 putative cosubstrate binding site; other site 1064539011644 catalytic site [active] 1064539011645 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1064539011646 substrate binding site [chemical binding]; other site 1064539011647 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1064539011648 active site 1064539011649 catalytic residues [active] 1064539011650 metal binding site [ion binding]; metal-binding site 1064539011651 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539011652 DNA-binding site [nucleotide binding]; DNA binding site 1064539011653 RNA-binding motif; other site 1064539011654 RmuC family; Region: RmuC; pfam02646 1064539011655 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1064539011656 nudix motif; other site 1064539011657 Protein of unknown function, DUF399; Region: DUF399; pfam04187 1064539011658 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064539011659 protein binding site [polypeptide binding]; other site 1064539011660 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1064539011661 classical (c) SDRs; Region: SDR_c; cd05233 1064539011662 NAD(P) binding site [chemical binding]; other site 1064539011663 active site 1064539011664 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064539011665 putative binding surface; other site 1064539011666 active site 1064539011667 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539011668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1064539011669 phosphorylation site [posttranslational modification] 1064539011670 intermolecular recognition site; other site 1064539011671 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1064539011672 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1064539011673 substrate-cofactor binding pocket; other site 1064539011674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539011675 catalytic residue [active] 1064539011676 aminotransferase; Provisional; Region: PRK06105 1064539011677 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064539011678 inhibitor-cofactor binding pocket; inhibition site 1064539011679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539011680 catalytic residue [active] 1064539011681 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1064539011682 glutathionine S-transferase; Provisional; Region: PRK10542 1064539011683 C-terminal domain interface [polypeptide binding]; other site 1064539011684 GSH binding site (G-site) [chemical binding]; other site 1064539011685 dimer interface [polypeptide binding]; other site 1064539011686 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1064539011687 N-terminal domain interface [polypeptide binding]; other site 1064539011688 dimer interface [polypeptide binding]; other site 1064539011689 substrate binding pocket (H-site) [chemical binding]; other site 1064539011690 PAS fold; Region: PAS_4; pfam08448 1064539011691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539011692 putative active site [active] 1064539011693 heme pocket [chemical binding]; other site 1064539011694 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539011695 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539011696 metal binding site [ion binding]; metal-binding site 1064539011697 active site 1064539011698 I-site; other site 1064539011699 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539011700 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064539011701 Ligand Binding Site [chemical binding]; other site 1064539011702 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1064539011703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539011704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539011705 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1064539011706 putative effector binding pocket; other site 1064539011707 dimerization interface [polypeptide binding]; other site 1064539011708 putative transporter; Provisional; Region: PRK10504 1064539011709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539011710 putative substrate translocation pore; other site 1064539011711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539011712 enoyl-CoA hydratase; Provisional; Region: PRK06127 1064539011713 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539011714 substrate binding site [chemical binding]; other site 1064539011715 oxyanion hole (OAH) forming residues; other site 1064539011716 trimer interface [polypeptide binding]; other site 1064539011717 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 1064539011718 peptide binding site [polypeptide binding]; other site 1064539011719 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1064539011720 dimer interface [polypeptide binding]; other site 1064539011721 potential frameshift: common BLAST hit: gi|83311077|ref|YP_421341.1| ABC-type dipeptide/oligopeptide/nickel transport systems 1064539011722 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539011723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539011724 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539011725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539011726 ABC-ATPase subunit interface; other site 1064539011727 putative PBP binding loops; other site 1064539011728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1064539011729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539011730 dimer interface [polypeptide binding]; other site 1064539011731 conserved gate region; other site 1064539011732 putative PBP binding loops; other site 1064539011733 ABC-ATPase subunit interface; other site 1064539011734 PrcB C-terminal; Region: PrcB_C; pfam14343 1064539011735 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1064539011736 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1064539011737 C-terminal domain interface [polypeptide binding]; other site 1064539011738 GSH binding site (G-site) [chemical binding]; other site 1064539011739 dimer interface [polypeptide binding]; other site 1064539011740 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1064539011741 N-terminal domain interface [polypeptide binding]; other site 1064539011742 dimer interface [polypeptide binding]; other site 1064539011743 substrate binding pocket (H-site) [chemical binding]; other site 1064539011744 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1064539011745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539011746 FeS/SAM binding site; other site 1064539011747 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1064539011748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1064539011749 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1064539011750 DTW domain; Region: DTW; cl01221 1064539011751 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 1064539011752 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1064539011753 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1064539011754 putative active site [active] 1064539011755 putative PHP Thumb interface [polypeptide binding]; other site 1064539011756 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1064539011757 generic binding surface II; other site 1064539011758 generic binding surface I; other site 1064539011759 Evidence 2b : Function of strongly homologous gene; PubMedId : 15886391; Product type e : enzyme 1064539011760 Evidence 2b : Function of strongly homologous gene; PubMedId : 15886391; Product type e : enzyme 1064539011761 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1064539011762 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1064539011763 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1064539011764 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1064539011765 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1064539011766 putative C-terminal domain interface [polypeptide binding]; other site 1064539011767 putative GSH binding site (G-site) [chemical binding]; other site 1064539011768 putative dimer interface [polypeptide binding]; other site 1064539011769 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1064539011770 putative substrate binding pocket (H-site) [chemical binding]; other site 1064539011771 putative N-terminal domain interface [polypeptide binding]; other site 1064539011772 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1064539011773 interface (dimer of trimers) [polypeptide binding]; other site 1064539011774 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1064539011775 Substrate-binding/catalytic site; other site 1064539011776 Zn-binding sites [ion binding]; other site 1064539011777 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1064539011778 FliG C-terminal domain; Region: FliG_C; pfam01706 1064539011779 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064539011780 MarR family; Region: MarR; pfam01047 1064539011781 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1064539011782 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1064539011783 putative ligand binding site [chemical binding]; other site 1064539011784 NAD binding site [chemical binding]; other site 1064539011785 dimerization interface [polypeptide binding]; other site 1064539011786 catalytic site [active] 1064539011787 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1064539011788 pseudouridine synthase; Region: TIGR00093 1064539011789 active site 1064539011790 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1064539011791 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539011792 Walker A/P-loop; other site 1064539011793 ATP binding site [chemical binding]; other site 1064539011794 Q-loop/lid; other site 1064539011795 ABC transporter signature motif; other site 1064539011796 Walker B; other site 1064539011797 D-loop; other site 1064539011798 H-loop/switch region; other site 1064539011799 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1064539011800 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539011801 Walker A/P-loop; other site 1064539011802 ATP binding site [chemical binding]; other site 1064539011803 Q-loop/lid; other site 1064539011804 ABC transporter signature motif; other site 1064539011805 Walker B; other site 1064539011806 D-loop; other site 1064539011807 H-loop/switch region; other site 1064539011808 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1064539011809 putative active site [active] 1064539011810 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1064539011811 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1064539011812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539011813 dimer interface [polypeptide binding]; other site 1064539011814 conserved gate region; other site 1064539011815 ABC-ATPase subunit interface; other site 1064539011816 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1064539011817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539011818 dimer interface [polypeptide binding]; other site 1064539011819 conserved gate region; other site 1064539011820 putative PBP binding loops; other site 1064539011821 ABC-ATPase subunit interface; other site 1064539011822 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1064539011823 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1064539011824 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1064539011825 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1064539011826 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1064539011827 amphipathic channel; other site 1064539011828 Asn-Pro-Ala signature motifs; other site 1064539011829 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1064539011830 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1064539011831 active site 1064539011832 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1064539011833 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1064539011834 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1064539011835 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1064539011836 putative NADH binding site [chemical binding]; other site 1064539011837 putative active site [active] 1064539011838 nudix motif; other site 1064539011839 putative metal binding site [ion binding]; other site 1064539011840 prephenate dehydratase; Provisional; Region: PRK11899 1064539011841 Prephenate dehydratase; Region: PDT; pfam00800 1064539011842 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1064539011843 putative L-Phe binding site [chemical binding]; other site 1064539011844 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1064539011845 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1064539011846 Ligand binding site; other site 1064539011847 oligomer interface; other site 1064539011848 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1064539011849 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1064539011850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539011851 Walker A motif; other site 1064539011852 ATP binding site [chemical binding]; other site 1064539011853 Walker B motif; other site 1064539011854 arginine finger; other site 1064539011855 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1064539011856 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 1064539011857 hypothetical protein; Validated; Region: PRK00153 1064539011858 recombination protein RecR; Reviewed; Region: recR; PRK00076 1064539011859 RecR protein; Region: RecR; pfam02132 1064539011860 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1064539011861 putative active site [active] 1064539011862 putative metal-binding site [ion binding]; other site 1064539011863 tetramer interface [polypeptide binding]; other site 1064539011864 Phosphoglycerate kinase; Region: PGK; pfam00162 1064539011865 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1064539011866 substrate binding site [chemical binding]; other site 1064539011867 hinge regions; other site 1064539011868 ADP binding site [chemical binding]; other site 1064539011869 catalytic site [active] 1064539011870 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539011871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539011872 S-adenosylmethionine binding site [chemical binding]; other site 1064539011873 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1064539011874 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1064539011875 putative active site [active] 1064539011876 putative metal binding residues [ion binding]; other site 1064539011877 signature motif; other site 1064539011878 putative triphosphate binding site [ion binding]; other site 1064539011879 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1064539011880 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1064539011881 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539011882 P-loop; other site 1064539011883 Magnesium ion binding site [ion binding]; other site 1064539011884 PAS domain S-box; Region: sensory_box; TIGR00229 1064539011885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539011886 putative active site [active] 1064539011887 heme pocket [chemical binding]; other site 1064539011888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539011889 PAS fold; Region: PAS_3; pfam08447 1064539011890 putative active site [active] 1064539011891 heme pocket [chemical binding]; other site 1064539011892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1064539011893 Histidine kinase; Region: HisKA_2; pfam07568 1064539011894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539011895 ATP binding site [chemical binding]; other site 1064539011896 Mg2+ binding site [ion binding]; other site 1064539011897 G-X-G motif; other site 1064539011898 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 1064539011899 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1064539011900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539011901 S-adenosylmethionine binding site [chemical binding]; other site 1064539011902 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539011903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539011904 ATP binding site [chemical binding]; other site 1064539011905 Mg2+ binding site [ion binding]; other site 1064539011906 G-X-G motif; other site 1064539011907 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1064539011908 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1064539011909 putative ribose interaction site [chemical binding]; other site 1064539011910 putative ADP binding site [chemical binding]; other site 1064539011911 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1064539011912 active site 1064539011913 nucleotide binding site [chemical binding]; other site 1064539011914 HIGH motif; other site 1064539011915 KMSKS motif; other site 1064539011916 Entericidin EcnA/B family; Region: Entericidin; pfam08085 1064539011917 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1064539011918 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1064539011919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539011920 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1064539011921 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1064539011922 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064539011923 active site 1064539011924 DNA binding site [nucleotide binding] 1064539011925 Int/Topo IB signature motif; other site 1064539011926 Protein of unknown function, DUF484; Region: DUF484; cl17449 1064539011927 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1064539011928 active site 1064539011929 intersubunit interactions; other site 1064539011930 catalytic residue [active] 1064539011931 primosome assembly protein PriA; Validated; Region: PRK05580 1064539011932 Helix-turn-helix domain; Region: HTH_20; pfam12840 1064539011933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064539011934 ATP binding site [chemical binding]; other site 1064539011935 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1064539011936 putative Mg++ binding site [ion binding]; other site 1064539011937 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1064539011938 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1064539011939 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1064539011940 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1064539011941 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1064539011942 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1064539011943 beta subunit interaction interface [polypeptide binding]; other site 1064539011944 Walker A motif; other site 1064539011945 ATP binding site [chemical binding]; other site 1064539011946 Walker B motif; other site 1064539011947 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1064539011948 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1064539011949 core domain interface [polypeptide binding]; other site 1064539011950 delta subunit interface [polypeptide binding]; other site 1064539011951 epsilon subunit interface [polypeptide binding]; other site 1064539011952 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1064539011953 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1064539011954 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1064539011955 alpha subunit interaction interface [polypeptide binding]; other site 1064539011956 Walker A motif; other site 1064539011957 ATP binding site [chemical binding]; other site 1064539011958 Walker B motif; other site 1064539011959 inhibitor binding site; inhibition site 1064539011960 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1064539011961 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1064539011962 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1064539011963 gamma subunit interface [polypeptide binding]; other site 1064539011964 epsilon subunit interface [polypeptide binding]; other site 1064539011965 LBP interface [polypeptide binding]; other site 1064539011966 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1064539011967 dinuclear metal binding motif [ion binding]; other site 1064539011968 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1064539011969 putative active site [active] 1064539011970 Ap4A binding site [chemical binding]; other site 1064539011971 nudix motif; other site 1064539011972 putative metal binding site [ion binding]; other site 1064539011973 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1064539011974 NodB motif; other site 1064539011975 putative active site [active] 1064539011976 putative catalytic site [active] 1064539011977 Zn binding site [ion binding]; other site 1064539011978 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1064539011979 C-terminal peptidase (prc); Region: prc; TIGR00225 1064539011980 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1064539011981 protein binding site [polypeptide binding]; other site 1064539011982 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1064539011983 Catalytic dyad [active] 1064539011984 Evidence 4 : Homologs of previously reported genes of unknown function 1064539011985 Evidence 4 : Homologs of previously reported genes of unknown function 1064539011986 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1064539011987 phosphoglyceromutase; Provisional; Region: PRK05434 1064539011988 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1064539011989 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1064539011990 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1064539011991 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1064539011992 active site 1064539011993 (T/H)XGH motif; other site 1064539011994 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1064539011995 putative catalytic cysteine [active] 1064539011996 Cytochrome c; Region: Cytochrom_C; pfam00034 1064539011997 Cytochrome c; Region: Cytochrom_C; cl11414 1064539011998 hypothetical protein; Provisional; Region: PRK10621 1064539011999 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1064539012000 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1064539012001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539012002 motif II; other site 1064539012003 gamma-glutamyl kinase; Provisional; Region: PRK05429 1064539012004 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1064539012005 nucleotide binding site [chemical binding]; other site 1064539012006 homotetrameric interface [polypeptide binding]; other site 1064539012007 putative phosphate binding site [ion binding]; other site 1064539012008 putative allosteric binding site; other site 1064539012009 PUA domain; Region: PUA; pfam01472 1064539012010 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1064539012011 GTP1/OBG; Region: GTP1_OBG; pfam01018 1064539012012 Obg GTPase; Region: Obg; cd01898 1064539012013 G1 box; other site 1064539012014 GTP/Mg2+ binding site [chemical binding]; other site 1064539012015 Switch I region; other site 1064539012016 G2 box; other site 1064539012017 G3 box; other site 1064539012018 Switch II region; other site 1064539012019 G4 box; other site 1064539012020 G5 box; other site 1064539012021 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1064539012022 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1064539012023 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1064539012024 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1064539012025 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1064539012026 substrate binding pocket [chemical binding]; other site 1064539012027 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539012028 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539012029 Walker A/P-loop; other site 1064539012030 ATP binding site [chemical binding]; other site 1064539012031 Q-loop/lid; other site 1064539012032 ABC transporter signature motif; other site 1064539012033 Walker B; other site 1064539012034 D-loop; other site 1064539012035 H-loop/switch region; other site 1064539012036 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539012037 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539012038 Walker A/P-loop; other site 1064539012039 ATP binding site [chemical binding]; other site 1064539012040 Q-loop/lid; other site 1064539012041 ABC transporter signature motif; other site 1064539012042 Walker B; other site 1064539012043 D-loop; other site 1064539012044 H-loop/switch region; other site 1064539012045 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539012046 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539012047 TM-ABC transporter signature motif; other site 1064539012048 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1064539012049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539012050 I-site; other site 1064539012051 active site 1064539012052 metal binding site [ion binding]; metal-binding site 1064539012053 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1064539012054 Ligand Binding Site [chemical binding]; other site 1064539012055 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1064539012056 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539012057 FeS/SAM binding site; other site 1064539012058 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1064539012059 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539012060 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539012061 TM-ABC transporter signature motif; other site 1064539012062 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539012063 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 1064539012064 putative ligand binding site [chemical binding]; other site 1064539012065 Protein of unknown function, DUF462; Region: DUF462; cl01190 1064539012066 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1064539012067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1064539012068 dimerization interface [polypeptide binding]; other site 1064539012069 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539012070 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539012071 dimer interface [polypeptide binding]; other site 1064539012072 putative CheW interface [polypeptide binding]; other site 1064539012073 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1064539012074 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1064539012075 Ligand binding site; other site 1064539012076 Putative Catalytic site; other site 1064539012077 DXD motif; other site 1064539012078 Beta-lactamase; Region: Beta-lactamase; cl17358 1064539012079 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1064539012080 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1064539012081 SnoaL-like domain; Region: SnoaL_3; pfam13474 1064539012082 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1064539012083 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1064539012084 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1064539012085 [2Fe-2S] cluster binding site [ion binding]; other site 1064539012086 NAD synthetase; Provisional; Region: PRK13981 1064539012087 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1064539012088 multimer interface [polypeptide binding]; other site 1064539012089 active site 1064539012090 catalytic triad [active] 1064539012091 protein interface 1 [polypeptide binding]; other site 1064539012092 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1064539012093 homodimer interface [polypeptide binding]; other site 1064539012094 NAD binding pocket [chemical binding]; other site 1064539012095 ATP binding pocket [chemical binding]; other site 1064539012096 Mg binding site [ion binding]; other site 1064539012097 active-site loop [active] 1064539012098 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1064539012099 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1064539012100 conserved cys residue [active] 1064539012101 indolepyruvate/phenylpyruvate decarboxylase, Azospirillum family; Region: indol_phenyl_DC; TIGR03394 1064539012102 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1064539012103 dimer interface [polypeptide binding]; other site 1064539012104 PYR/PP interface [polypeptide binding]; other site 1064539012105 TPP binding site [chemical binding]; other site 1064539012106 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064539012107 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1064539012108 TPP-binding site [chemical binding]; other site 1064539012109 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 1064539012110 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1064539012111 active site 1064539012112 HIGH motif; other site 1064539012113 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1064539012114 active site 1064539012115 KMSKS motif; other site 1064539012116 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1064539012117 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1064539012118 active site 1064539012119 HIGH motif; other site 1064539012120 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1064539012121 KMSKS motif; other site 1064539012122 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1064539012123 tRNA binding surface [nucleotide binding]; other site 1064539012124 anticodon binding site; other site 1064539012125 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1064539012126 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1064539012127 CHASE domain; Region: CHASE; pfam03924 1064539012128 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539012129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539012130 dimer interface [polypeptide binding]; other site 1064539012131 phosphorylation site [posttranslational modification] 1064539012132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539012133 ATP binding site [chemical binding]; other site 1064539012134 Mg2+ binding site [ion binding]; other site 1064539012135 G-X-G motif; other site 1064539012136 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539012137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539012138 active site 1064539012139 phosphorylation site [posttranslational modification] 1064539012140 intermolecular recognition site; other site 1064539012141 dimerization interface [polypeptide binding]; other site 1064539012142 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1064539012143 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1064539012144 active site 1064539012145 catalytic residues [active] 1064539012146 metal binding site [ion binding]; metal-binding site 1064539012147 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1064539012148 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1064539012149 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1064539012150 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1064539012151 LytTr DNA-binding domain; Region: LytTR; smart00850 1064539012152 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1064539012153 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1064539012154 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064539012155 RNA binding surface [nucleotide binding]; other site 1064539012156 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1064539012157 PemK-like protein; Region: PemK; pfam02452 1064539012158 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1064539012159 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1064539012160 FMN binding site [chemical binding]; other site 1064539012161 active site 1064539012162 substrate binding site [chemical binding]; other site 1064539012163 catalytic residue [active] 1064539012164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539012165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539012166 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1064539012167 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1064539012168 putative GSH binding site [chemical binding]; other site 1064539012169 catalytic residues [active] 1064539012170 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1064539012171 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1064539012172 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1064539012173 dimerization interface [polypeptide binding]; other site 1064539012174 ATP binding site [chemical binding]; other site 1064539012175 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1064539012176 dimerization interface [polypeptide binding]; other site 1064539012177 ATP binding site [chemical binding]; other site 1064539012178 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1064539012179 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1064539012180 putative active site [active] 1064539012181 catalytic triad [active] 1064539012182 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064539012183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539012184 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1064539012185 dimerization interface [polypeptide binding]; other site 1064539012186 substrate binding pocket [chemical binding]; other site 1064539012187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539012188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1064539012189 MOSC domain; Region: MOSC; pfam03473 1064539012190 3-alpha domain; Region: 3-alpha; pfam03475 1064539012191 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1064539012192 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1064539012193 helix-hairpin-helix signature motif; other site 1064539012194 substrate binding pocket [chemical binding]; other site 1064539012195 active site 1064539012196 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1064539012197 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1064539012198 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1064539012199 ATP binding site [chemical binding]; other site 1064539012200 active site 1064539012201 substrate binding site [chemical binding]; other site 1064539012202 Evidence 4 : Homologs of previously reported genes of unknown function 1064539012203 Evidence 4 : Homologs of previously reported genes of unknown function 1064539012204 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 1064539012205 adenylosuccinate lyase; Provisional; Region: PRK07492 1064539012206 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1064539012207 tetramer interface [polypeptide binding]; other site 1064539012208 active site 1064539012209 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1064539012210 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1064539012211 PAS domain S-box; Region: sensory_box; TIGR00229 1064539012212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539012213 PAS domain; Region: PAS_9; pfam13426 1064539012214 putative active site [active] 1064539012215 heme pocket [chemical binding]; other site 1064539012216 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539012217 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539012218 metal binding site [ion binding]; metal-binding site 1064539012219 active site 1064539012220 I-site; other site 1064539012221 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539012222 tellurium resistance terB-like protein; Region: terB_like; cd07177 1064539012223 metal binding site [ion binding]; metal-binding site 1064539012224 hypothetical protein; Reviewed; Region: PRK00024 1064539012225 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1064539012226 MPN+ (JAMM) motif; other site 1064539012227 Zinc-binding site [ion binding]; other site 1064539012228 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1064539012229 active site 1064539012230 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1064539012231 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1064539012232 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1064539012233 putative MPT binding site; other site 1064539012234 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1064539012235 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1064539012236 heme binding site [chemical binding]; other site 1064539012237 ferroxidase pore; other site 1064539012238 ferroxidase diiron center [ion binding]; other site 1064539012239 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1064539012240 Transglycosylase; Region: Transgly; cl17702 1064539012241 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1064539012242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539012243 binding surface 1064539012244 TPR motif; other site 1064539012245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539012246 binding surface 1064539012247 TPR motif; other site 1064539012248 TPR repeat; Region: TPR_11; pfam13414 1064539012249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539012250 binding surface 1064539012251 TPR motif; other site 1064539012252 TPR repeat; Region: TPR_11; pfam13414 1064539012253 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1064539012254 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1064539012255 dimer interface [polypeptide binding]; other site 1064539012256 motif 1; other site 1064539012257 active site 1064539012258 motif 2; other site 1064539012259 motif 3; other site 1064539012260 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1064539012261 anticodon binding site; other site 1064539012262 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1064539012263 active site 1064539012264 substrate binding pocket [chemical binding]; other site 1064539012265 dimer interface [polypeptide binding]; other site 1064539012266 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1064539012267 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1064539012268 generic binding surface II; other site 1064539012269 generic binding surface I; other site 1064539012270 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1064539012271 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1064539012272 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1064539012273 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1064539012274 HEPN domain; Region: HEPN; cl00824 1064539012275 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1064539012276 active site 1064539012277 NTP binding site [chemical binding]; other site 1064539012278 metal binding triad [ion binding]; metal-binding site 1064539012279 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1064539012280 nucleoside/Zn binding site; other site 1064539012281 dimer interface [polypeptide binding]; other site 1064539012282 catalytic motif [active] 1064539012283 Dodecin; Region: Dodecin; pfam07311 1064539012284 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1064539012285 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064539012286 RNA binding surface [nucleotide binding]; other site 1064539012287 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1064539012288 active site 1064539012289 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1064539012290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1064539012291 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1064539012292 trehalose synthase; Region: treS_nterm; TIGR02456 1064539012293 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1064539012294 active site 1064539012295 catalytic site [active] 1064539012296 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1064539012297 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1064539012298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539012299 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539012300 substrate binding pocket [chemical binding]; other site 1064539012301 membrane-bound complex binding site; other site 1064539012302 hinge residues; other site 1064539012303 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1064539012304 EF-hand domain pair; Region: EF_hand_5; pfam13499 1064539012305 Ca2+ binding site [ion binding]; other site 1064539012306 Predicted integral membrane protein [Function unknown]; Region: COG5616 1064539012307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539012308 TPR motif; other site 1064539012309 binding surface 1064539012310 TPR repeat; Region: TPR_11; pfam13414 1064539012311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539012312 TPR motif; other site 1064539012313 binding surface 1064539012314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539012315 TPR motif; other site 1064539012316 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1064539012317 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1064539012318 PGAP1-like protein; Region: PGAP1; pfam07819 1064539012319 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 1064539012320 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1064539012321 metal binding triad [ion binding]; metal-binding site 1064539012322 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1064539012323 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 1064539012324 tellurium resistance terB-like protein; Region: terB_like; cd07177 1064539012325 metal binding site [ion binding]; metal-binding site 1064539012326 phosphate acetyltransferase; Provisional; Region: PRK11890 1064539012327 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 1064539012328 propionate/acetate kinase; Provisional; Region: PRK12379 1064539012329 Acetokinase family; Region: Acetate_kinase; cl17229 1064539012330 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539012331 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539012332 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539012333 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539012334 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539012335 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539012336 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1064539012337 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1064539012338 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1064539012339 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1064539012340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539012341 NAD(P) binding site [chemical binding]; other site 1064539012342 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1064539012343 active site 1064539012344 DctM-like transporters; Region: DctM; pfam06808 1064539012345 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1064539012346 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1064539012347 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539012348 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539012349 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539012350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539012351 DNA-binding site [nucleotide binding]; DNA binding site 1064539012352 FCD domain; Region: FCD; pfam07729 1064539012353 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1064539012354 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1064539012355 Metal-binding active site; metal-binding site 1064539012356 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1064539012357 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1064539012358 Ligand binding site; other site 1064539012359 Putative Catalytic site; other site 1064539012360 DXD motif; other site 1064539012361 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1064539012362 putative acyl-acceptor binding pocket; other site 1064539012363 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1064539012364 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1064539012365 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1064539012366 dimer interface [polypeptide binding]; other site 1064539012367 active site 1064539012368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539012369 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1064539012370 NAD(P) binding site [chemical binding]; other site 1064539012371 active site 1064539012372 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1064539012373 active site 2 [active] 1064539012374 active site 1 [active] 1064539012375 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1064539012376 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1064539012377 dimer interface [polypeptide binding]; other site 1064539012378 active site 1064539012379 Predicted exporter [General function prediction only]; Region: COG4258 1064539012380 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 1064539012381 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1064539012382 active site 1064539012383 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1064539012384 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539012385 AMP binding site [chemical binding]; other site 1064539012386 active site 1064539012387 acyl-activating enzyme (AAE) consensus motif; other site 1064539012388 CoA binding site [chemical binding]; other site 1064539012389 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1064539012390 active site 2 [active] 1064539012391 active site 1 [active] 1064539012392 Predicted membrane protein [Function unknown]; Region: COG4648 1064539012393 acyl carrier protein; Provisional; Region: PRK05350 1064539012394 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1064539012395 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1064539012396 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1064539012397 putative acyl-acceptor binding pocket; other site 1064539012398 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1064539012399 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1064539012400 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1064539012401 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1064539012402 PAS domain S-box; Region: sensory_box; TIGR00229 1064539012403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539012404 PAS domain; Region: PAS_9; pfam13426 1064539012405 putative active site [active] 1064539012406 heme pocket [chemical binding]; other site 1064539012407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539012408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539012409 dimer interface [polypeptide binding]; other site 1064539012410 phosphorylation site [posttranslational modification] 1064539012411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539012412 ATP binding site [chemical binding]; other site 1064539012413 Mg2+ binding site [ion binding]; other site 1064539012414 G-X-G motif; other site 1064539012415 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539012416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539012417 active site 1064539012418 phosphorylation site [posttranslational modification] 1064539012419 intermolecular recognition site; other site 1064539012420 dimerization interface [polypeptide binding]; other site 1064539012421 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1064539012422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539012423 putative active site [active] 1064539012424 heme pocket [chemical binding]; other site 1064539012425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539012426 Walker A motif; other site 1064539012427 ATP binding site [chemical binding]; other site 1064539012428 Walker B motif; other site 1064539012429 arginine finger; other site 1064539012430 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1064539012431 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1064539012432 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1064539012433 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1064539012434 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1064539012435 tetramer interface [polypeptide binding]; other site 1064539012436 TPP-binding site [chemical binding]; other site 1064539012437 heterodimer interface [polypeptide binding]; other site 1064539012438 phosphorylation loop region [posttranslational modification] 1064539012439 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1064539012440 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1064539012441 alpha subunit interface [polypeptide binding]; other site 1064539012442 TPP binding site [chemical binding]; other site 1064539012443 heterodimer interface [polypeptide binding]; other site 1064539012444 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064539012445 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1064539012446 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1064539012447 E3 interaction surface; other site 1064539012448 lipoyl attachment site [posttranslational modification]; other site 1064539012449 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1064539012450 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1064539012451 acetoin reductases; Region: 23BDH; TIGR02415 1064539012452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539012453 NAD(P) binding site [chemical binding]; other site 1064539012454 active site 1064539012455 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1064539012456 lipoyl synthase; Provisional; Region: PRK05481 1064539012457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539012458 FeS/SAM binding site; other site 1064539012459 classical (c) SDRs; Region: SDR_c; cd05233 1064539012460 NAD(P) binding site [chemical binding]; other site 1064539012461 active site 1064539012462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539012463 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064539012464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539012465 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1064539012466 dimerization interface [polypeptide binding]; other site 1064539012467 substrate binding pocket [chemical binding]; other site 1064539012468 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1064539012469 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 1064539012470 Trp docking motif [polypeptide binding]; other site 1064539012471 dimer interface [polypeptide binding]; other site 1064539012472 active site 1064539012473 small subunit binding site [polypeptide binding]; other site 1064539012474 Cytochrome c; Region: Cytochrom_C; pfam00034 1064539012475 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1064539012476 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1064539012477 Cytochrome c; Region: Cytochrom_C; pfam00034 1064539012478 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1064539012479 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1064539012480 D-pathway; other site 1064539012481 Putative ubiquinol binding site [chemical binding]; other site 1064539012482 Low-spin heme (heme b) binding site [chemical binding]; other site 1064539012483 Putative water exit pathway; other site 1064539012484 Binuclear center (heme o3/CuB) [ion binding]; other site 1064539012485 K-pathway; other site 1064539012486 Putative proton exit pathway; other site 1064539012487 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 1064539012488 Subunit I/III interface [polypeptide binding]; other site 1064539012489 Cytochrome c; Region: Cytochrom_C; cl11414 1064539012490 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 1064539012491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539012492 substrate binding pocket [chemical binding]; other site 1064539012493 membrane-bound complex binding site; other site 1064539012494 hinge residues; other site 1064539012495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539012496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064539012497 dimerization interface [polypeptide binding]; other site 1064539012498 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064539012499 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1064539012500 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539012501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539012502 dimer interface [polypeptide binding]; other site 1064539012503 conserved gate region; other site 1064539012504 putative PBP binding loops; other site 1064539012505 ABC-ATPase subunit interface; other site 1064539012506 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1064539012507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539012508 dimer interface [polypeptide binding]; other site 1064539012509 conserved gate region; other site 1064539012510 ABC-ATPase subunit interface; other site 1064539012511 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1064539012512 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539012513 Walker A/P-loop; other site 1064539012514 ATP binding site [chemical binding]; other site 1064539012515 Q-loop/lid; other site 1064539012516 ABC transporter signature motif; other site 1064539012517 Walker B; other site 1064539012518 D-loop; other site 1064539012519 H-loop/switch region; other site 1064539012520 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539012521 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539012522 Walker A/P-loop; other site 1064539012523 ATP binding site [chemical binding]; other site 1064539012524 Q-loop/lid; other site 1064539012525 ABC transporter signature motif; other site 1064539012526 Walker B; other site 1064539012527 D-loop; other site 1064539012528 H-loop/switch region; other site 1064539012529 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539012530 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1064539012531 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1064539012532 active site pocket [active] 1064539012533 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1064539012534 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1064539012535 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539012536 catalytic residue [active] 1064539012537 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1064539012538 homotrimer interaction site [polypeptide binding]; other site 1064539012539 putative active site [active] 1064539012540 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539012541 Family description; Region: VCBS; pfam13517 1064539012542 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 1064539012543 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 1064539012544 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539012545 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539012546 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539012547 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539012548 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1064539012549 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1064539012550 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1064539012551 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 1064539012552 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1064539012553 putative hydrophobic ligand binding site [chemical binding]; other site 1064539012554 protein interface [polypeptide binding]; other site 1064539012555 gate; other site 1064539012556 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 1064539012557 hypothetical protein; Provisional; Region: PRK02399 1064539012558 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1064539012559 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 1064539012560 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1064539012561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539012562 Walker A motif; other site 1064539012563 ATP binding site [chemical binding]; other site 1064539012564 Walker B motif; other site 1064539012565 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539012566 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 1064539012567 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539012568 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1064539012569 putative ligand binding site [chemical binding]; other site 1064539012570 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8540696; Product type t : transporter 1064539012571 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8540696; Product type t : transporter 1064539012572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539012573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539012574 active site 1064539012575 phosphorylation site [posttranslational modification] 1064539012576 intermolecular recognition site; other site 1064539012577 dimerization interface [polypeptide binding]; other site 1064539012578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539012579 DNA binding site [nucleotide binding] 1064539012580 HAMP domain; Region: HAMP; pfam00672 1064539012581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539012582 dimer interface [polypeptide binding]; other site 1064539012583 phosphorylation site [posttranslational modification] 1064539012584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539012585 ATP binding site [chemical binding]; other site 1064539012586 Mg2+ binding site [ion binding]; other site 1064539012587 G-X-G motif; other site 1064539012588 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1064539012589 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539012590 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539012591 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1064539012592 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1064539012593 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539012594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1064539012595 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1064539012596 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539012597 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1064539012598 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1064539012599 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1064539012600 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1064539012601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539012602 ATP binding site [chemical binding]; other site 1064539012603 Mg2+ binding site [ion binding]; other site 1064539012604 G-X-G motif; other site 1064539012605 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1064539012606 ATP binding site [chemical binding]; other site 1064539012607 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1064539012608 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1064539012609 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1064539012610 active site 1064539012611 dimer interface [polypeptide binding]; other site 1064539012612 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1064539012613 dimer interface [polypeptide binding]; other site 1064539012614 active site 1064539012615 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1064539012616 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1064539012617 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1064539012618 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1064539012619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1064539012620 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 1064539012621 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1064539012622 lipoprotein signal peptidase; Provisional; Region: PRK14787 1064539012623 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 1064539012624 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1064539012625 active site 1064539012626 HIGH motif; other site 1064539012627 nucleotide binding site [chemical binding]; other site 1064539012628 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1064539012629 active site 1064539012630 KMSKS motif; other site 1064539012631 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1064539012632 tRNA binding surface [nucleotide binding]; other site 1064539012633 anticodon binding site; other site 1064539012634 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1064539012635 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064539012636 active site 1064539012637 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1064539012638 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1064539012639 active site 1064539012640 Riboflavin kinase; Region: Flavokinase; pfam01687 1064539012641 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1064539012642 dimer interaction site [polypeptide binding]; other site 1064539012643 substrate-binding tunnel; other site 1064539012644 active site 1064539012645 catalytic site [active] 1064539012646 substrate binding site [chemical binding]; other site 1064539012647 classical (c) SDRs; Region: SDR_c; cd05233 1064539012648 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1064539012649 NAD(P) binding site [chemical binding]; other site 1064539012650 active site 1064539012651 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1064539012652 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1064539012653 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1064539012654 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1064539012655 Hemerythrin; Region: Hemerythrin; cd12107 1064539012656 Fe binding site [ion binding]; other site 1064539012657 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1064539012658 ATP binding site [chemical binding]; other site 1064539012659 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 1064539012660 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1064539012661 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1064539012662 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1064539012663 active site 1064539012664 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1064539012665 TSCPD domain; Region: TSCPD; pfam12637 1064539012666 Hemerythrin; Region: Hemerythrin; cd12107 1064539012667 Fe binding site [ion binding]; other site 1064539012668 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1064539012669 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1064539012670 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1064539012671 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1064539012672 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1064539012673 homotrimer interaction site [polypeptide binding]; other site 1064539012674 putative active site [active] 1064539012675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1064539012676 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1064539012677 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1064539012678 nucleoside/Zn binding site; other site 1064539012679 dimer interface [polypeptide binding]; other site 1064539012680 catalytic motif [active] 1064539012681 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539012682 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539012683 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539012684 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539012685 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539012686 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539012687 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539012688 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539012689 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539012690 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1064539012691 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064539012692 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1064539012693 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1064539012694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539012695 Walker A motif; other site 1064539012696 ATP binding site [chemical binding]; other site 1064539012697 Walker B motif; other site 1064539012698 arginine finger; other site 1064539012699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539012700 Walker A motif; other site 1064539012701 ATP binding site [chemical binding]; other site 1064539012702 Walker B motif; other site 1064539012703 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1064539012704 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1064539012705 Phasin protein; Region: Phasin_2; pfam09361 1064539012706 Phasin protein; Region: Phasin_2; pfam09361 1064539012707 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1064539012708 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1064539012709 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1064539012710 Sporulation related domain; Region: SPOR; pfam05036 1064539012711 PBP superfamily domain; Region: PBP_like_2; pfam12849 1064539012712 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1064539012713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539012714 dimer interface [polypeptide binding]; other site 1064539012715 conserved gate region; other site 1064539012716 putative PBP binding loops; other site 1064539012717 ABC-ATPase subunit interface; other site 1064539012718 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 1064539012719 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1064539012720 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1064539012721 GTP binding site; other site 1064539012722 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 1064539012723 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 1064539012724 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 1064539012725 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1064539012726 [4Fe-4S] binding site [ion binding]; other site 1064539012727 molybdopterin cofactor binding site; other site 1064539012728 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064539012729 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1064539012730 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1064539012731 molybdopterin cofactor binding site; other site 1064539012732 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1064539012733 4Fe-4S binding domain; Region: Fer4; cl02805 1064539012734 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1064539012735 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1064539012736 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1064539012737 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1064539012738 structural tetrad; other site 1064539012739 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1064539012740 intersubunit interface [polypeptide binding]; other site 1064539012741 active site 1064539012742 Zn2+ binding site [ion binding]; other site 1064539012743 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539012744 HAMP domain; Region: HAMP; pfam00672 1064539012745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539012746 dimer interface [polypeptide binding]; other site 1064539012747 phosphorylation site [posttranslational modification] 1064539012748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539012749 ATP binding site [chemical binding]; other site 1064539012750 Mg2+ binding site [ion binding]; other site 1064539012751 G-X-G motif; other site 1064539012752 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1064539012753 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1064539012754 putative active site [active] 1064539012755 metal binding site [ion binding]; metal-binding site 1064539012756 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1064539012757 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 1064539012758 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1064539012759 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1064539012760 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 1064539012761 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1064539012762 ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Region: ATP_synt_6_or_A; TIGR01131 1064539012763 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1064539012764 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1064539012765 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1064539012766 Cu(I) binding site [ion binding]; other site 1064539012767 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1064539012768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539012769 dimerization interface [polypeptide binding]; other site 1064539012770 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539012771 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539012772 dimer interface [polypeptide binding]; other site 1064539012773 putative CheW interface [polypeptide binding]; other site 1064539012774 Hemerythrin; Region: Hemerythrin; cd12107 1064539012775 Fe binding site [ion binding]; other site 1064539012776 PhoH-like protein; Region: PhoH; pfam02562 1064539012777 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1064539012778 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1064539012779 septum formation inhibitor; Reviewed; Region: minC; PRK04804 1064539012780 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1064539012781 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1064539012782 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1064539012783 P-loop; other site 1064539012784 ADP binding residues [chemical binding]; other site 1064539012785 Switch I; other site 1064539012786 Switch II; other site 1064539012787 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1064539012788 potential frameshift: common BLAST hit: gi|86605626|ref|YP_474389.1| FG-GAP repeat- ASPIC/UnbV domain-containing protein 1064539012789 Family description; Region: VCBS; pfam13517 1064539012790 Family description; Region: VCBS; pfam13517 1064539012791 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 1064539012792 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539012793 PAS fold; Region: PAS_3; pfam08447 1064539012794 putative active site [active] 1064539012795 heme pocket [chemical binding]; other site 1064539012796 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539012797 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539012798 dimer interface [polypeptide binding]; other site 1064539012799 putative CheW interface [polypeptide binding]; other site 1064539012800 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539012801 putative CheW interface [polypeptide binding]; other site 1064539012802 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1064539012803 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1064539012804 active site 1064539012805 Cupin domain; Region: Cupin_2; pfam07883 1064539012806 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1064539012807 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1064539012808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539012809 catalytic residue [active] 1064539012810 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539012811 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539012812 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1064539012813 aromatic arch; other site 1064539012814 DCoH dimer interaction site [polypeptide binding]; other site 1064539012815 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1064539012816 DCoH tetramer interaction site [polypeptide binding]; other site 1064539012817 substrate binding site [chemical binding]; other site 1064539012818 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1064539012819 active site 1064539012820 Fe-S cluster binding site [ion binding]; other site 1064539012821 glucokinase; Provisional; Region: glk; PRK00292 1064539012822 glucokinase, proteobacterial type; Region: glk; TIGR00749 1064539012823 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1064539012824 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1064539012825 active site 1064539012826 homotetramer interface [polypeptide binding]; other site 1064539012827 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1064539012828 HAMP domain; Region: HAMP; pfam00672 1064539012829 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539012830 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539012831 dimer interface [polypeptide binding]; other site 1064539012832 putative CheW interface [polypeptide binding]; other site 1064539012833 PilZ domain; Region: PilZ; pfam07238 1064539012834 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 1064539012835 active site 1064539012836 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1064539012837 AAA domain; Region: AAA_30; pfam13604 1064539012838 Family description; Region: UvrD_C_2; pfam13538 1064539012839 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539012840 DNA-binding site [nucleotide binding]; DNA binding site 1064539012841 RNA-binding motif; other site 1064539012842 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539012843 DNA-binding site [nucleotide binding]; DNA binding site 1064539012844 RNA-binding motif; other site 1064539012845 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539012846 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539012847 ligand binding site [chemical binding]; other site 1064539012848 flexible hinge region; other site 1064539012849 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1064539012850 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 1064539012851 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 1064539012852 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1064539012853 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539012854 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539012855 dimer interface [polypeptide binding]; other site 1064539012856 putative CheW interface [polypeptide binding]; other site 1064539012857 PilZ domain; Region: PilZ; pfam07238 1064539012858 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1064539012859 oxidoreductase; Provisional; Region: PRK10015 1064539012860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1064539012861 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1064539012862 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1064539012863 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1064539012864 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1064539012865 Ligand binding site [chemical binding]; other site 1064539012866 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1064539012867 Nitrogen fixation protein NifW; Region: NifW; pfam03206 1064539012868 serine O-acetyltransferase; Region: cysE; TIGR01172 1064539012869 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1064539012870 trimer interface [polypeptide binding]; other site 1064539012871 active site 1064539012872 substrate binding site [chemical binding]; other site 1064539012873 CoA binding site [chemical binding]; other site 1064539012874 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 1064539012875 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 1064539012876 active site 1064539012877 catalytic residues [active] 1064539012878 metal binding site [ion binding]; metal-binding site 1064539012879 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1064539012880 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1064539012881 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539012882 catalytic residue [active] 1064539012883 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 1064539012884 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1064539012885 trimerization site [polypeptide binding]; other site 1064539012886 active site 1064539012887 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1064539012888 NifU-like domain; Region: NifU; pfam01106 1064539012889 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1064539012890 NifQ; Region: NifQ; pfam04891 1064539012891 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 1064539012892 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1064539012893 Rop-like; Region: Rop-like; pfam05082 1064539012894 probable nitrogen fixation protein; Region: TIGR02935 1064539012895 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1064539012896 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1064539012897 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1064539012898 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 1064539012899 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1064539012900 PAS domain; Region: PAS_9; pfam13426 1064539012901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539012902 putative active site [active] 1064539012903 heme pocket [chemical binding]; other site 1064539012904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539012905 PAS domain; Region: PAS_9; pfam13426 1064539012906 putative active site [active] 1064539012907 heme pocket [chemical binding]; other site 1064539012908 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539012909 dimer interface [polypeptide binding]; other site 1064539012910 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1064539012911 putative CheW interface [polypeptide binding]; other site 1064539012912 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1064539012913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539012914 Predicted transcriptional regulator [Transcription]; Region: COG1959 1064539012915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064539012916 putative Zn2+ binding site [ion binding]; other site 1064539012917 putative DNA binding site [nucleotide binding]; other site 1064539012918 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1064539012919 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1064539012920 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1064539012921 MoFe protein beta/alpha subunit interactions; other site 1064539012922 Beta subunit P cluster binding residues; other site 1064539012923 MoFe protein beta subunit/Fe protein contacts; other site 1064539012924 MoFe protein dimer/ dimer interactions; other site 1064539012925 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1064539012926 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1064539012927 MoFe protein alpha/beta subunit interactions; other site 1064539012928 Alpha subunit P cluster binding residues; other site 1064539012929 FeMoco binding residues [chemical binding]; other site 1064539012930 MoFe protein alpha subunit/Fe protein contacts; other site 1064539012931 MoFe protein dimer/ dimer interactions; other site 1064539012932 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 1064539012933 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1064539012934 Nucleotide-binding sites [chemical binding]; other site 1064539012935 Walker A motif; other site 1064539012936 Switch I region of nucleotide binding site; other site 1064539012937 Fe4S4 binding sites [ion binding]; other site 1064539012938 Switch II region of nucleotide binding site; other site 1064539012939 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 1064539012940 ADP-ribosyl-[dinitrogen reductase] hydrolase; Region: dinitro_DRAG; TIGR02662 1064539012941 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 1064539012942 putative catalytic residues [active] 1064539012943 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1064539012944 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1064539012945 putative active site [active] 1064539012946 putative dimer interface [polypeptide binding]; other site 1064539012947 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1064539012948 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1064539012949 SIR2-like domain; Region: SIR2_2; pfam13289 1064539012950 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1064539012951 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1064539012952 inhibitor-cofactor binding pocket; inhibition site 1064539012953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539012954 catalytic residue [active] 1064539012955 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 18562278, 1885524, 3054814, 9503607; Product type e : enzyme 1064539012956 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 18562278, 1885524, 3054814, 9503607; Product type e : enzyme 1064539012957 NifZ domain; Region: NifZ; pfam04319 1064539012958 NifZ domain; Region: NifZ; pfam04319 1064539012959 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 1064539012960 hypothetical protein; Provisional; Region: PRK13795 1064539012961 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1064539012962 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539012963 FeS/SAM binding site; other site 1064539012964 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1064539012965 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1064539012966 cyclase homology domain; Region: CHD; cd07302 1064539012967 nucleotidyl binding site; other site 1064539012968 metal binding site [ion binding]; metal-binding site 1064539012969 dimer interface [polypeptide binding]; other site 1064539012970 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1064539012971 phosphopeptide binding site; other site 1064539012972 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10518727, 12552819, 1362170, 15887032, 1779763, 8759845,9178550; Product type r : regulator 1064539012973 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10518727, 12552819, 1362170, 15887032, 1779763, 8759845,9178550; Product type r : regulator 1064539012974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539012975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539012976 N terminus of Rad21 / Rec8 like protein; Region: Rad21_Rec8_N; pfam04825 1064539012977 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539012978 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539012979 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1064539012980 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1064539012981 Walker A/P-loop; other site 1064539012982 ATP binding site [chemical binding]; other site 1064539012983 Q-loop/lid; other site 1064539012984 ABC transporter signature motif; other site 1064539012985 Walker B; other site 1064539012986 D-loop; other site 1064539012987 H-loop/switch region; other site 1064539012988 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1064539012989 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064539012990 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1064539012991 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1064539012992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539012993 S-adenosylmethionine binding site [chemical binding]; other site 1064539012994 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1064539012995 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539012996 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1064539012997 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1064539012998 FAD binding domain; Region: FAD_binding_4; pfam01565 1064539012999 FAD binding domain; Region: FAD_binding_4; pfam01565 1064539013000 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1064539013001 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1064539013002 Cysteine-rich domain; Region: CCG; pfam02754 1064539013003 Cysteine-rich domain; Region: CCG; pfam02754 1064539013004 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1064539013005 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1064539013006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539013007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064539013008 active site 1064539013009 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1064539013010 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539013011 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539013012 catalytic residue [active] 1064539013013 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1064539013014 FAD binding domain; Region: FAD_binding_4; pfam01565 1064539013015 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1064539013016 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1064539013017 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539013018 P-loop; other site 1064539013019 Magnesium ion binding site [ion binding]; other site 1064539013020 Protein of unknown function (DUF563); Region: DUF563; pfam04577 1064539013021 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1064539013022 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1064539013023 catalytic triad [active] 1064539013024 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2567108, 2876389; Product type e : enzyme 1064539013025 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2567108, 2876389; Product type e : enzyme 1064539013026 Protein of unknown function; Region: DUF3971; pfam13116 1064539013027 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1064539013028 Calx-beta domain; Region: Calx-beta; cl02522 1064539013029 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1064539013030 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1064539013031 active site 1064539013032 HIGH motif; other site 1064539013033 dimer interface [polypeptide binding]; other site 1064539013034 KMSKS motif; other site 1064539013035 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1064539013036 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1064539013037 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1064539013038 serine O-acetyltransferase; Region: cysE; TIGR01172 1064539013039 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1064539013040 trimer interface [polypeptide binding]; other site 1064539013041 active site 1064539013042 substrate binding site [chemical binding]; other site 1064539013043 CoA binding site [chemical binding]; other site 1064539013044 Transcriptional regulator; Region: Rrf2; cl17282 1064539013045 Rrf2 family protein; Region: rrf2_super; TIGR00738 1064539013046 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1064539013047 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1064539013048 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539013049 catalytic residue [active] 1064539013050 co-chaperone HscB; Provisional; Region: hscB; PRK03578 1064539013051 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1064539013052 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064539013053 catalytic loop [active] 1064539013054 iron binding site [ion binding]; other site 1064539013055 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12549933, 8969519, 7541255; Product type e : enzyme 1064539013056 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12549933, 8969519, 7541255; Product type e : enzyme 1064539013057 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1064539013058 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1064539013059 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1064539013060 putative NADH binding site [chemical binding]; other site 1064539013061 putative active site [active] 1064539013062 nudix motif; other site 1064539013063 putative metal binding site [ion binding]; other site 1064539013064 YCII-related domain; Region: YCII; cl00999 1064539013065 EamA-like transporter family; Region: EamA; pfam00892 1064539013066 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1064539013067 EamA-like transporter family; Region: EamA; pfam00892 1064539013068 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1064539013069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539013070 motif II; other site 1064539013071 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1064539013072 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1064539013073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539013074 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1064539013075 NAD(P) binding site [chemical binding]; other site 1064539013076 active site 1064539013077 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1064539013078 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539013079 acyl-activating enzyme (AAE) consensus motif; other site 1064539013080 active site 1064539013081 AMP binding site [chemical binding]; other site 1064539013082 CoA binding site [chemical binding]; other site 1064539013083 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 1064539013084 classical (c) SDRs; Region: SDR_c; cd05233 1064539013085 NAD(P) binding site [chemical binding]; other site 1064539013086 active site 1064539013087 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1064539013088 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12749836, 16672515, 6261245, 6270337,6271455; Product type e : enzyme 1064539013089 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12749836, 16672515, 6261245, 6270337,6271455; Product type e : enzyme 1064539013090 virion protein; Provisional; Region: V; PHA02564 1064539013091 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 1064539013092 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539013093 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539013094 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1427098; Product type t : transporter 1064539013095 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1427098; Product type t : transporter 1064539013096 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2184029; Product type t : transporter 1064539013097 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2184029; Product type t : transporter 1064539013098 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1064539013099 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 1064539013100 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1064539013101 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1064539013102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539013103 NAD(P) binding site [chemical binding]; other site 1064539013104 active site 1064539013105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539013106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539013107 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1064539013108 putative effector binding pocket; other site 1064539013109 putative dimerization interface [polypeptide binding]; other site 1064539013110 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1064539013111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539013112 S-adenosylmethionine binding site [chemical binding]; other site 1064539013113 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539013114 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1064539013115 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 1064539013116 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539013117 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539013118 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539013119 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539013120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539013121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539013122 dimer interface [polypeptide binding]; other site 1064539013123 phosphorylation site [posttranslational modification] 1064539013124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539013125 ATP binding site [chemical binding]; other site 1064539013126 Mg2+ binding site [ion binding]; other site 1064539013127 G-X-G motif; other site 1064539013128 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539013129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539013130 active site 1064539013131 phosphorylation site [posttranslational modification] 1064539013132 intermolecular recognition site; other site 1064539013133 dimerization interface [polypeptide binding]; other site 1064539013134 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539013135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539013136 active site 1064539013137 phosphorylation site [posttranslational modification] 1064539013138 intermolecular recognition site; other site 1064539013139 dimerization interface [polypeptide binding]; other site 1064539013140 NifQ; Region: NifQ; pfam04891 1064539013141 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1064539013142 putative hydrophobic ligand binding site [chemical binding]; other site 1064539013143 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1064539013144 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1064539013145 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1064539013146 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1064539013147 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1064539013148 Protein of unknown function DUF72; Region: DUF72; pfam01904 1064539013149 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1064539013150 Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; Region: HOT; cd08190 1064539013151 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1064539013152 putative active site [active] 1064539013153 metal binding site [ion binding]; metal-binding site 1064539013154 Phage Tail Collar Domain; Region: Collar; pfam07484 1064539013155 Phage Tail Collar Domain; Region: Collar; pfam07484 1064539013156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1064539013157 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1064539013158 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1064539013159 putative ADP-binding pocket [chemical binding]; other site 1064539013160 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539013161 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1064539013162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539013163 Coenzyme A binding pocket [chemical binding]; other site 1064539013164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1064539013165 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1064539013166 Coenzyme A binding pocket [chemical binding]; other site 1064539013167 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1064539013168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539013169 Coenzyme A binding pocket [chemical binding]; other site 1064539013170 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1064539013171 Class II fumarases; Region: Fumarase_classII; cd01362 1064539013172 active site 1064539013173 tetramer interface [polypeptide binding]; other site 1064539013174 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1064539013175 Protein of unknown function, DUF599; Region: DUF599; pfam04654 1064539013176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539013177 putative active site [active] 1064539013178 heme pocket [chemical binding]; other site 1064539013179 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539013180 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1064539013181 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 1064539013182 ATP-grasp domain; Region: ATP-grasp; pfam02222 1064539013183 AIR carboxylase; Region: AIRC; pfam00731 1064539013184 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 1064539013185 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1064539013186 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1064539013187 active site 1064539013188 ADP/pyrophosphate binding site [chemical binding]; other site 1064539013189 dimerization interface [polypeptide binding]; other site 1064539013190 allosteric effector site; other site 1064539013191 fructose-1,6-bisphosphate binding site; other site 1064539013192 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1064539013193 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1064539013194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539013195 TPR motif; other site 1064539013196 binding surface 1064539013197 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1064539013198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539013199 TPR motif; other site 1064539013200 binding surface 1064539013201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539013202 binding surface 1064539013203 TPR motif; other site 1064539013204 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539013205 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1064539013206 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1064539013207 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1064539013208 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064539013209 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1064539013210 active site clefts [active] 1064539013211 zinc binding site [ion binding]; other site 1064539013212 dimer interface [polypeptide binding]; other site 1064539013213 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1064539013214 Flavoprotein; Region: Flavoprotein; pfam02441 1064539013215 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 1064539013216 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1064539013217 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1064539013218 NAD(P) binding site [chemical binding]; other site 1064539013219 Protein of unknown function (DUF1192); Region: DUF1192; cl11573 1064539013220 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1064539013221 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 1064539013222 Evidence 5 : No homology to any previously reported sequences 1064539013223 Evidence 5 : No homology to any previously reported sequences 1064539013224 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1064539013225 Membrane fusogenic activity; Region: BMFP; pfam04380 1064539013226 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1064539013227 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1064539013228 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1064539013229 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1064539013230 putative deacylase active site [active] 1064539013231 acyl-CoA synthetase; Validated; Region: PRK08162 1064539013232 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1064539013233 acyl-activating enzyme (AAE) consensus motif; other site 1064539013234 putative active site [active] 1064539013235 AMP binding site [chemical binding]; other site 1064539013236 putative CoA binding site [chemical binding]; other site 1064539013237 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1064539013238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539013239 Coenzyme A binding pocket [chemical binding]; other site 1064539013240 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539013241 dimerization interface [polypeptide binding]; other site 1064539013242 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539013243 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539013244 dimer interface [polypeptide binding]; other site 1064539013245 putative CheW interface [polypeptide binding]; other site 1064539013246 O-Antigen ligase; Region: Wzy_C; pfam04932 1064539013247 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1064539013248 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1064539013249 putative active site [active] 1064539013250 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1064539013251 epoxyqueuosine reductase; Region: TIGR00276 1064539013252 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1064539013253 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 1064539013254 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 1064539013255 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1064539013256 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1064539013257 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1064539013258 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1064539013259 potential frameshift: common BLAST hit: gi|288958937|ref|YP_003449278.1| aarF domain-containing kinase 1064539013260 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1064539013261 ABC1 family; Region: ABC1; pfam03109 1064539013262 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1064539013263 active site 1064539013264 ATP binding site [chemical binding]; other site 1064539013265 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1064539013266 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1064539013267 FAD binding domain; Region: FAD_binding_4; pfam01565 1064539013268 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1064539013269 Berberine and berberine like; Region: BBE; pfam08031 1064539013270 Hemerythrin; Region: Hemerythrin; cd12107 1064539013271 Fe binding site [ion binding]; other site 1064539013272 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1064539013273 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1064539013274 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 1064539013275 active site 1064539013276 Zn binding site [ion binding]; other site 1064539013277 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1064539013278 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1064539013279 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1064539013280 acyl-activating enzyme (AAE) consensus motif; other site 1064539013281 putative AMP binding site [chemical binding]; other site 1064539013282 putative active site [active] 1064539013283 putative CoA binding site [chemical binding]; other site 1064539013284 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1064539013285 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1064539013286 active site residue [active] 1064539013287 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1064539013288 active site residue [active] 1064539013289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539013290 RNA polymerase factor sigma-70; Validated; Region: PRK09047 1064539013291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539013292 DNA binding residues [nucleotide binding] 1064539013293 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1064539013294 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1064539013295 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539013296 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539013297 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539013298 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539013299 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539013300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539013301 active site 1064539013302 phosphorylation site [posttranslational modification] 1064539013303 intermolecular recognition site; other site 1064539013304 dimerization interface [polypeptide binding]; other site 1064539013305 FOG: CBS domain [General function prediction only]; Region: COG0517 1064539013306 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1064539013307 Cation efflux family; Region: Cation_efflux; cl00316 1064539013308 anthranilate synthase; Provisional; Region: PRK13566 1064539013309 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1064539013310 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1064539013311 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1064539013312 glutamine binding [chemical binding]; other site 1064539013313 catalytic triad [active] 1064539013314 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 1064539013315 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1064539013316 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1064539013317 ligand binding site [chemical binding]; other site 1064539013318 homodimer interface [polypeptide binding]; other site 1064539013319 NAD(P) binding site [chemical binding]; other site 1064539013320 trimer interface B [polypeptide binding]; other site 1064539013321 trimer interface A [polypeptide binding]; other site 1064539013322 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1064539013323 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1064539013324 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1064539013325 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1064539013326 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1064539013327 oligomerization interface [polypeptide binding]; other site 1064539013328 active site 1064539013329 metal binding site [ion binding]; metal-binding site 1064539013330 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1064539013331 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1064539013332 active site 1064539013333 catalytic residues [active] 1064539013334 metal binding site [ion binding]; metal-binding site 1064539013335 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 1064539013336 COQ9; Region: COQ9; pfam08511 1064539013337 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1064539013338 Stringent starvation protein B; Region: SspB; pfam04386 1064539013339 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1064539013340 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1064539013341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539013342 binding surface 1064539013343 TPR motif; other site 1064539013344 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1064539013345 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539013346 Protein of unknown function (DUF983); Region: DUF983; cl02211 1064539013347 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1064539013348 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1064539013349 zinc binding site [ion binding]; other site 1064539013350 putative ligand binding site [chemical binding]; other site 1064539013351 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1064539013352 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539013353 TM-ABC transporter signature motif; other site 1064539013354 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1064539013355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539013356 Walker A/P-loop; other site 1064539013357 ATP binding site [chemical binding]; other site 1064539013358 Q-loop/lid; other site 1064539013359 ABC transporter signature motif; other site 1064539013360 Walker B; other site 1064539013361 D-loop; other site 1064539013362 H-loop/switch region; other site 1064539013363 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1064539013364 TrkA-N domain; Region: TrkA_N; pfam02254 1064539013365 Domain of unknown function DUF59; Region: DUF59; pfam01883 1064539013366 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1064539013367 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8248183; Product type r : regulator 1064539013368 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8248183; Product type r : regulator 1064539013369 HflC protein; Region: hflC; TIGR01932 1064539013370 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1064539013371 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 1064539013372 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1064539013373 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539013374 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064539013375 protein binding site [polypeptide binding]; other site 1064539013376 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064539013377 protein binding site [polypeptide binding]; other site 1064539013378 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1064539013379 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1064539013380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539013381 motif II; other site 1064539013382 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1064539013383 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1064539013384 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1064539013385 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1064539013386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539013387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539013388 homodimer interface [polypeptide binding]; other site 1064539013389 catalytic residue [active] 1064539013390 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 1064539013391 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1064539013392 PYR/PP interface [polypeptide binding]; other site 1064539013393 dimer interface [polypeptide binding]; other site 1064539013394 TPP binding site [chemical binding]; other site 1064539013395 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064539013396 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1064539013397 TPP-binding site [chemical binding]; other site 1064539013398 dimer interface [polypeptide binding]; other site 1064539013399 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1064539013400 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1064539013401 putative valine binding site [chemical binding]; other site 1064539013402 dimer interface [polypeptide binding]; other site 1064539013403 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1064539013404 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1064539013405 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1064539013406 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1064539013407 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1064539013408 PhoU domain; Region: PhoU; pfam01895 1064539013409 PhoU domain; Region: PhoU; pfam01895 1064539013410 hypothetical protein; Provisional; Region: PRK05208 1064539013411 rod shape-determining protein MreB; Provisional; Region: PRK13927 1064539013412 MreB and similar proteins; Region: MreB_like; cd10225 1064539013413 nucleotide binding site [chemical binding]; other site 1064539013414 Mg binding site [ion binding]; other site 1064539013415 putative protofilament interaction site [polypeptide binding]; other site 1064539013416 RodZ interaction site [polypeptide binding]; other site 1064539013417 rod shape-determining protein MreC; Provisional; Region: PRK13922 1064539013418 rod shape-determining protein MreC; Region: MreC; pfam04085 1064539013419 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1064539013420 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1064539013421 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1064539013422 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1064539013423 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539013424 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539013425 dimer interface [polypeptide binding]; other site 1064539013426 putative CheW interface [polypeptide binding]; other site 1064539013427 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1064539013428 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1064539013429 LysE type translocator; Region: LysE; cl00565 1064539013430 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1064539013431 ligand binding site [chemical binding]; other site 1064539013432 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1064539013433 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1064539013434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539013435 Walker A/P-loop; other site 1064539013436 ATP binding site [chemical binding]; other site 1064539013437 Q-loop/lid; other site 1064539013438 ABC transporter signature motif; other site 1064539013439 Walker B; other site 1064539013440 D-loop; other site 1064539013441 H-loop/switch region; other site 1064539013442 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1064539013443 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1064539013444 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539013445 TM-ABC transporter signature motif; other site 1064539013446 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539013447 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1064539013448 TM-ABC transporter signature motif; other site 1064539013449 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1064539013450 active site 1064539013451 catalytic motif [active] 1064539013452 Zn binding site [ion binding]; other site 1064539013453 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1064539013454 Class I aldolases; Region: Aldolase_Class_I; cl17187 1064539013455 catalytic residue [active] 1064539013456 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6286410, 9698549; Product type e : enzyme 1064539013457 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6286410, 9698549; Product type e : enzyme 1064539013458 phytoene desaturase; Region: crtI_fam; TIGR02734 1064539013459 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539013460 EamA-like transporter family; Region: EamA; pfam00892 1064539013461 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1064539013462 anti sigma factor interaction site; other site 1064539013463 regulatory phosphorylation site [posttranslational modification]; other site 1064539013464 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1064539013465 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1064539013466 ligand binding site [chemical binding]; other site 1064539013467 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539013468 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539013469 TM-ABC transporter signature motif; other site 1064539013470 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539013471 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539013472 TM-ABC transporter signature motif; other site 1064539013473 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539013474 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539013475 Walker A/P-loop; other site 1064539013476 ATP binding site [chemical binding]; other site 1064539013477 Q-loop/lid; other site 1064539013478 ABC transporter signature motif; other site 1064539013479 Walker B; other site 1064539013480 D-loop; other site 1064539013481 H-loop/switch region; other site 1064539013482 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539013483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539013484 Walker A/P-loop; other site 1064539013485 ATP binding site [chemical binding]; other site 1064539013486 Q-loop/lid; other site 1064539013487 ABC transporter signature motif; other site 1064539013488 Walker B; other site 1064539013489 D-loop; other site 1064539013490 H-loop/switch region; other site 1064539013491 Evidence 2b : Function of strongly homologous gene; Product type t : transporter 1064539013492 Evidence 2b : Function of strongly homologous gene; Product type t : transporter 1064539013493 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1064539013494 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1064539013495 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1064539013496 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1064539013497 active site 1064539013498 catalytic site [active] 1064539013499 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1064539013500 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1064539013501 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1064539013502 active site 1064539013503 homodimer interface [polypeptide binding]; other site 1064539013504 catalytic site [active] 1064539013505 acceptor binding site [chemical binding]; other site 1064539013506 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539013507 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1064539013508 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1064539013509 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1064539013510 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1064539013511 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1064539013512 Catalytic site; other site 1064539013513 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1064539013514 two-component response regulator; Provisional; Region: PRK09191 1064539013515 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539013516 DNA binding residues [nucleotide binding] 1064539013517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539013518 active site 1064539013519 phosphorylation site [posttranslational modification] 1064539013520 intermolecular recognition site; other site 1064539013521 dimerization interface [polypeptide binding]; other site 1064539013522 Predicted membrane protein [Function unknown]; Region: COG2261 1064539013523 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1064539013524 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1064539013525 substrate binding site [chemical binding]; other site 1064539013526 hexamer interface [polypeptide binding]; other site 1064539013527 metal binding site [ion binding]; metal-binding site 1064539013528 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1064539013529 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1064539013530 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1064539013531 putative NAD(P) binding site [chemical binding]; other site 1064539013532 dimer interface [polypeptide binding]; other site 1064539013533 Predicted transcriptional regulators [Transcription]; Region: COG1733 1064539013534 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1064539013535 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11882718 1064539013536 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11882718 1064539013537 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1064539013538 glucose-1-dehydrogenase; Provisional; Region: PRK06947 1064539013539 classical (c) SDRs; Region: SDR_c; cd05233 1064539013540 NAD(P) binding site [chemical binding]; other site 1064539013541 active site 1064539013542 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1064539013543 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1064539013544 tetramer interface [polypeptide binding]; other site 1064539013545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539013546 catalytic residue [active] 1064539013547 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064539013548 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1064539013549 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1064539013550 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1064539013551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539013552 motif II; other site 1064539013553 NnrS protein; Region: NnrS; pfam05940 1064539013554 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1064539013555 MPT binding site; other site 1064539013556 trimer interface [polypeptide binding]; other site 1064539013557 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1064539013558 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1064539013559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1064539013560 Predicted membrane protein [Function unknown]; Region: COG1238 1064539013561 PAS domain; Region: PAS_9; pfam13426 1064539013562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539013563 putative active site [active] 1064539013564 heme pocket [chemical binding]; other site 1064539013565 PAS fold; Region: PAS_7; pfam12860 1064539013566 PAS fold; Region: PAS; pfam00989 1064539013567 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539013568 putative active site [active] 1064539013569 heme pocket [chemical binding]; other site 1064539013570 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539013571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539013572 dimer interface [polypeptide binding]; other site 1064539013573 phosphorylation site [posttranslational modification] 1064539013574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539013575 ATP binding site [chemical binding]; other site 1064539013576 Mg2+ binding site [ion binding]; other site 1064539013577 G-X-G motif; other site 1064539013578 pyruvate kinase; Provisional; Region: PRK06247 1064539013579 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1064539013580 domain interfaces; other site 1064539013581 active site 1064539013582 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1064539013583 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1064539013584 30S ribosomal protein S11; Validated; Region: PRK05309 1064539013585 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1064539013586 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1064539013587 alphaNTD - beta interaction site [polypeptide binding]; other site 1064539013588 alphaNTD homodimer interface [polypeptide binding]; other site 1064539013589 alphaNTD - beta' interaction site [polypeptide binding]; other site 1064539013590 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1064539013591 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1064539013592 Predicted membrane protein [Function unknown]; Region: COG1238 1064539013593 recombination factor protein RarA; Reviewed; Region: PRK13342 1064539013594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539013595 Walker A motif; other site 1064539013596 ATP binding site [chemical binding]; other site 1064539013597 Walker B motif; other site 1064539013598 arginine finger; other site 1064539013599 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1064539013600 camphor resistance protein CrcB; Provisional; Region: PRK14195 1064539013601 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1064539013602 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1064539013603 active site 1064539013604 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539013605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539013606 DNA-binding site [nucleotide binding]; DNA binding site 1064539013607 FCD domain; Region: FCD; pfam07729 1064539013608 Benzoate membrane transport protein; Region: BenE; pfam03594 1064539013609 benzoate transporter; Region: benE; TIGR00843 1064539013610 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1064539013611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539013612 motif II; other site 1064539013613 ATP12 chaperone protein; Region: ATP12; cl02228 1064539013614 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1064539013615 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1064539013616 PRC-barrel domain; Region: PRC; pfam05239 1064539013617 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1064539013618 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1064539013619 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1064539013620 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1064539013621 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1064539013622 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1064539013623 Walker A/P-loop; other site 1064539013624 ATP binding site [chemical binding]; other site 1064539013625 Q-loop/lid; other site 1064539013626 ABC transporter signature motif; other site 1064539013627 Walker B; other site 1064539013628 D-loop; other site 1064539013629 H-loop/switch region; other site 1064539013630 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1064539013631 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539013632 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1064539013633 TM-ABC transporter signature motif; other site 1064539013634 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1064539013635 TM-ABC transporter signature motif; other site 1064539013636 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1064539013637 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1064539013638 putative ligand binding site [chemical binding]; other site 1064539013639 NUDIX domain; Region: NUDIX; pfam00293 1064539013640 nudix motif; other site 1064539013641 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539013642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539013643 active site 1064539013644 phosphorylation site [posttranslational modification] 1064539013645 intermolecular recognition site; other site 1064539013646 dimerization interface [polypeptide binding]; other site 1064539013647 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539013648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539013649 metal binding site [ion binding]; metal-binding site 1064539013650 active site 1064539013651 I-site; other site 1064539013652 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 1064539013653 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1064539013654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064539013655 active site 1064539013656 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1064539013657 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064539013658 Beta-Casp domain; Region: Beta-Casp; smart01027 1064539013659 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1064539013660 CHASE domain; Region: CHASE; pfam03924 1064539013661 PAS domain S-box; Region: sensory_box; TIGR00229 1064539013662 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539013663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539013664 metal binding site [ion binding]; metal-binding site 1064539013665 active site 1064539013666 I-site; other site 1064539013667 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539013668 short chain dehydrogenase; Provisional; Region: PRK07109 1064539013669 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1064539013670 putative NAD(P) binding site [chemical binding]; other site 1064539013671 active site 1064539013672 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1064539013673 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1064539013674 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1064539013675 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1064539013676 Hemerythrin-like domain; Region: Hr-like; cd12108 1064539013677 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1064539013678 dihydropteroate synthase; Region: DHPS; TIGR01496 1064539013679 substrate binding pocket [chemical binding]; other site 1064539013680 dimer interface [polypeptide binding]; other site 1064539013681 inhibitor binding site; inhibition site 1064539013682 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 1064539013683 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1064539013684 active site 1064539013685 substrate binding site [chemical binding]; other site 1064539013686 metal binding site [ion binding]; metal-binding site 1064539013687 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1064539013688 dimer interface [polypeptide binding]; other site 1064539013689 substrate binding site [chemical binding]; other site 1064539013690 ATP binding site [chemical binding]; other site 1064539013691 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1064539013692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539013693 DNA-binding site [nucleotide binding]; DNA binding site 1064539013694 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539013695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539013696 homodimer interface [polypeptide binding]; other site 1064539013697 catalytic residue [active] 1064539013698 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1064539013699 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1064539013700 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1064539013701 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1064539013702 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1064539013703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539013704 Coenzyme A binding pocket [chemical binding]; other site 1064539013705 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1064539013706 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1064539013707 putative active site [active] 1064539013708 putative catalytic site [active] 1064539013709 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1064539013710 nucleotide binding site [chemical binding]; other site 1064539013711 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1064539013712 SBD interface [polypeptide binding]; other site 1064539013713 glutamine synthetase; Provisional; Region: glnA; PRK09469 1064539013714 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1064539013715 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1064539013716 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1064539013717 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1064539013718 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1064539013719 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1064539013720 putative substrate binding site [chemical binding]; other site 1064539013721 putative ATP binding site [chemical binding]; other site 1064539013722 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 1064539013723 trigger factor; Provisional; Region: tig; PRK01490 1064539013724 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1064539013725 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1064539013726 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1064539013727 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1064539013728 oligomer interface [polypeptide binding]; other site 1064539013729 active site residues [active] 1064539013730 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1064539013731 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1064539013732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539013733 Walker A motif; other site 1064539013734 ATP binding site [chemical binding]; other site 1064539013735 Walker B motif; other site 1064539013736 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1064539013737 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1064539013738 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1064539013739 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1064539013740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539013741 Walker A motif; other site 1064539013742 ATP binding site [chemical binding]; other site 1064539013743 Walker B motif; other site 1064539013744 arginine finger; other site 1064539013745 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1064539013746 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1064539013747 IHF - DNA interface [nucleotide binding]; other site 1064539013748 IHF dimer interface [polypeptide binding]; other site 1064539013749 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1064539013750 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1064539013751 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1064539013752 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1064539013753 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1064539013754 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1064539013755 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1064539013756 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1064539013757 putative dimer interface [polypeptide binding]; other site 1064539013758 [2Fe-2S] cluster binding site [ion binding]; other site 1064539013759 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 1064539013760 SLBB domain; Region: SLBB; pfam10531 1064539013761 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1064539013762 NADH dehydrogenase subunit G; Validated; Region: PRK09130 1064539013763 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064539013764 catalytic loop [active] 1064539013765 iron binding site [ion binding]; other site 1064539013766 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1064539013767 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 1064539013768 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 1064539013769 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1064539013770 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1064539013771 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1064539013772 4Fe-4S binding domain; Region: Fer4; cl02805 1064539013773 4Fe-4S binding domain; Region: Fer4; pfam00037 1064539013774 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1064539013775 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1064539013776 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 1064539013777 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1064539013778 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1064539013779 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1064539013780 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1064539013781 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1064539013782 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1064539013783 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1064539013784 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1064539013785 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1064539013786 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1064539013787 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1064539013788 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1064539013789 conserved hypothetical protein; Region: MG423; TIGR00649 1064539013790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064539013791 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1064539013792 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064539013793 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1064539013794 dimer interface [polypeptide binding]; other site 1064539013795 substrate binding site [chemical binding]; other site 1064539013796 metal binding site [ion binding]; metal-binding site 1064539013797 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 1064539013798 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1064539013799 prolyl-tRNA synthetase; Provisional; Region: PRK12325 1064539013800 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1064539013801 dimer interface [polypeptide binding]; other site 1064539013802 motif 1; other site 1064539013803 active site 1064539013804 motif 2; other site 1064539013805 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1064539013806 active site 1064539013807 motif 3; other site 1064539013808 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1064539013809 anticodon binding site; other site 1064539013810 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1064539013811 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1064539013812 FtsX-like permease family; Region: FtsX; pfam02687 1064539013813 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1064539013814 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1064539013815 Walker A/P-loop; other site 1064539013816 ATP binding site [chemical binding]; other site 1064539013817 Q-loop/lid; other site 1064539013818 ABC transporter signature motif; other site 1064539013819 Walker B; other site 1064539013820 D-loop; other site 1064539013821 H-loop/switch region; other site 1064539013822 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1064539013823 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1064539013824 EamA-like transporter family; Region: EamA; pfam00892 1064539013825 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1064539013826 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1064539013827 putative active site [active] 1064539013828 putative PHP Thumb interface [polypeptide binding]; other site 1064539013829 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1064539013830 generic binding surface I; other site 1064539013831 generic binding surface II; other site 1064539013832 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1064539013833 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1064539013834 rRNA interaction site [nucleotide binding]; other site 1064539013835 S8 interaction site; other site 1064539013836 putative laminin-1 binding site; other site 1064539013837 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1447125, 6272196, 8596629, 9298646; Product type f : factor 1064539013838 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1447125, 6272196, 8596629, 9298646; Product type f : factor 1064539013839 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1064539013840 putative nucleotide binding site [chemical binding]; other site 1064539013841 uridine monophosphate binding site [chemical binding]; other site 1064539013842 homohexameric interface [polypeptide binding]; other site 1064539013843 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1064539013844 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1064539013845 hinge region; other site 1064539013846 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 1064539013847 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1064539013848 catalytic residue [active] 1064539013849 putative FPP diphosphate binding site; other site 1064539013850 putative FPP binding hydrophobic cleft; other site 1064539013851 dimer interface [polypeptide binding]; other site 1064539013852 putative IPP diphosphate binding site; other site 1064539013853 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1064539013854 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1064539013855 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1064539013856 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1064539013857 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1064539013858 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1064539013859 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1064539013860 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1064539013861 active site 1064539013862 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1064539013863 protein binding site [polypeptide binding]; other site 1064539013864 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1064539013865 putative substrate binding region [chemical binding]; other site 1064539013866 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1064539013867 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1064539013868 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1064539013869 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1064539013870 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1064539013871 Surface antigen; Region: Bac_surface_Ag; pfam01103 1064539013872 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1064539013873 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1064539013874 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1064539013875 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1064539013876 active site 1064539013877 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 1064539013878 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1064539013879 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1064539013880 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064539013881 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1064539013882 dimer interface [polypeptide binding]; other site 1064539013883 active site 1064539013884 metal binding site [ion binding]; metal-binding site 1064539013885 glutathione binding site [chemical binding]; other site 1064539013886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539013887 Coenzyme A binding pocket [chemical binding]; other site 1064539013888 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064539013889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539013890 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1064539013891 dimerization interface [polypeptide binding]; other site 1064539013892 substrate binding pocket [chemical binding]; other site 1064539013893 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1064539013894 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1064539013895 putative C-terminal domain interface [polypeptide binding]; other site 1064539013896 putative GSH binding site (G-site) [chemical binding]; other site 1064539013897 putative dimer interface [polypeptide binding]; other site 1064539013898 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1064539013899 N-terminal domain interface [polypeptide binding]; other site 1064539013900 dimer interface [polypeptide binding]; other site 1064539013901 substrate binding pocket (H-site) [chemical binding]; other site 1064539013902 potential frameshift: common BLAST hit: gi|374291616|ref|YP_005038651.1| citrate synthase 1064539013903 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1064539013904 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1064539013905 oxalacetate binding site [chemical binding]; other site 1064539013906 citrylCoA binding site [chemical binding]; other site 1064539013907 coenzyme A binding site [chemical binding]; other site 1064539013908 catalytic triad [active] 1064539013909 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1064539013910 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1064539013911 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1064539013912 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1064539013913 active site 1064539013914 HIGH motif; other site 1064539013915 nucleotide binding site [chemical binding]; other site 1064539013916 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1064539013917 active site 1064539013918 KMSKS motif; other site 1064539013919 potential frameshift: common BLAST hit: gi|288958448|ref|YP_003448789.1| ComEC/Rec2-like protein 1064539013920 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1064539013921 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1064539013922 Competence protein; Region: Competence; pfam03772 1064539013923 Competence protein; Region: Competence; pfam03772 1064539013924 LexA repressor; Validated; Region: PRK00215 1064539013925 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1064539013926 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1064539013927 Catalytic site [active] 1064539013928 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1064539013929 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1064539013930 dimer interface [polypeptide binding]; other site 1064539013931 putative functional site; other site 1064539013932 putative MPT binding site; other site 1064539013933 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1064539013934 trimer interface [polypeptide binding]; other site 1064539013935 dimer interface [polypeptide binding]; other site 1064539013936 putative active site [active] 1064539013937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539013938 Coenzyme A binding pocket [chemical binding]; other site 1064539013939 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1064539013940 active site 1064539013941 ribulose/triose binding site [chemical binding]; other site 1064539013942 phosphate binding site [ion binding]; other site 1064539013943 substrate (anthranilate) binding pocket [chemical binding]; other site 1064539013944 product (indole) binding pocket [chemical binding]; other site 1064539013945 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1064539013946 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1064539013947 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1064539013948 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1064539013949 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1064539013950 glutamine binding [chemical binding]; other site 1064539013951 catalytic triad [active] 1064539013952 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1064539013953 NodB motif; other site 1064539013954 putative active site [active] 1064539013955 putative catalytic site [active] 1064539013956 Zn binding site [ion binding]; other site 1064539013957 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1064539013958 metal-binding site [ion binding] 1064539013959 anthranilate synthase component I; Provisional; Region: PRK13573 1064539013960 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1064539013961 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1064539013962 SurA N-terminal domain; Region: SurA_N_3; cl07813 1064539013963 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1064539013964 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1064539013965 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1064539013966 substrate binding site [chemical binding]; other site 1064539013967 catalytic triad [active] 1064539013968 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1064539013969 CTP synthetase; Validated; Region: pyrG; PRK05380 1064539013970 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1064539013971 Catalytic site [active] 1064539013972 active site 1064539013973 UTP binding site [chemical binding]; other site 1064539013974 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1064539013975 active site 1064539013976 putative oxyanion hole; other site 1064539013977 catalytic triad [active] 1064539013978 Dienelactone hydrolase family; Region: DLH; pfam01738 1064539013979 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1064539013980 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1064539013981 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1064539013982 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1064539013983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539013984 FeS/SAM binding site; other site 1064539013985 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1064539013986 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 1064539013987 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1064539013988 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1064539013989 PqqA family; Region: PqqA; cl15372 1064539013990 enolase; Provisional; Region: eno; PRK00077 1064539013991 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1064539013992 dimer interface [polypeptide binding]; other site 1064539013993 metal binding site [ion binding]; metal-binding site 1064539013994 substrate binding pocket [chemical binding]; other site 1064539013995 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1064539013996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539013997 binding surface 1064539013998 TPR motif; other site 1064539013999 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1064539014000 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1064539014001 Ligand Binding Site [chemical binding]; other site 1064539014002 potential frameshift: common BLAST hit: gi|374291392|ref|YP_005038427.1| tRNA(Ile)-lysidine synthase 1064539014003 FtsH Extracellular; Region: FtsH_ext; pfam06480 1064539014004 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1064539014005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539014006 Walker A motif; other site 1064539014007 ATP binding site [chemical binding]; other site 1064539014008 Walker B motif; other site 1064539014009 arginine finger; other site 1064539014010 Peptidase family M41; Region: Peptidase_M41; pfam01434 1064539014011 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1064539014012 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 1064539014013 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1064539014014 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1064539014015 catalytic triad [active] 1064539014016 dimer interface [polypeptide binding]; other site 1064539014017 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1064539014018 active sites [active] 1064539014019 tetramer interface [polypeptide binding]; other site 1064539014020 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1064539014021 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539014022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539014023 Walker A/P-loop; other site 1064539014024 ATP binding site [chemical binding]; other site 1064539014025 Q-loop/lid; other site 1064539014026 ABC transporter signature motif; other site 1064539014027 Walker B; other site 1064539014028 D-loop; other site 1064539014029 H-loop/switch region; other site 1064539014030 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1064539014031 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539014032 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539014033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539014034 active site 1064539014035 phosphorylation site [posttranslational modification] 1064539014036 intermolecular recognition site; other site 1064539014037 dimerization interface [polypeptide binding]; other site 1064539014038 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1064539014039 PGAP1-like protein; Region: PGAP1; pfam07819 1064539014040 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1064539014041 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274131 1064539014042 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274131 1064539014043 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1064539014044 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1064539014045 active site residue [active] 1064539014046 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1064539014047 active site residue [active] 1064539014048 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1064539014049 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 1064539014050 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1064539014051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539014052 catalytic residue [active] 1064539014053 hypothetical protein; Provisional; Region: PRK07550 1064539014054 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539014055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539014056 homodimer interface [polypeptide binding]; other site 1064539014057 catalytic residue [active] 1064539014058 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1064539014059 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1064539014060 active site 1064539014061 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1064539014062 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539014063 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539014064 Walker A/P-loop; other site 1064539014065 ATP binding site [chemical binding]; other site 1064539014066 Q-loop/lid; other site 1064539014067 ABC transporter signature motif; other site 1064539014068 Walker B; other site 1064539014069 D-loop; other site 1064539014070 H-loop/switch region; other site 1064539014071 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539014072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539014073 dimer interface [polypeptide binding]; other site 1064539014074 conserved gate region; other site 1064539014075 ABC-ATPase subunit interface; other site 1064539014076 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1064539014077 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539014078 substrate binding pocket [chemical binding]; other site 1064539014079 membrane-bound complex binding site; other site 1064539014080 hinge residues; other site 1064539014081 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1064539014082 PAS fold; Region: PAS_7; pfam12860 1064539014083 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539014084 PAS domain; Region: PAS_8; pfam13188 1064539014085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539014086 dimer interface [polypeptide binding]; other site 1064539014087 phosphorylation site [posttranslational modification] 1064539014088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539014089 ATP binding site [chemical binding]; other site 1064539014090 Mg2+ binding site [ion binding]; other site 1064539014091 G-X-G motif; other site 1064539014092 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539014093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539014094 active site 1064539014095 phosphorylation site [posttranslational modification] 1064539014096 intermolecular recognition site; other site 1064539014097 dimerization interface [polypeptide binding]; other site 1064539014098 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 1064539014099 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539014100 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539014101 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 1064539014102 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1064539014103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1064539014104 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1064539014105 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539014106 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539014107 dimer interface [polypeptide binding]; other site 1064539014108 putative CheW interface [polypeptide binding]; other site 1064539014109 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1064539014110 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1064539014111 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 1064539014112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1064539014113 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1064539014114 HAMP domain; Region: HAMP; pfam00672 1064539014115 dimerization interface [polypeptide binding]; other site 1064539014116 PAS fold; Region: PAS_4; pfam08448 1064539014117 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539014118 putative active site [active] 1064539014119 heme pocket [chemical binding]; other site 1064539014120 PAS fold; Region: PAS_4; pfam08448 1064539014121 PAS domain S-box; Region: sensory_box; TIGR00229 1064539014122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539014123 putative active site [active] 1064539014124 heme pocket [chemical binding]; other site 1064539014125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539014126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539014127 ATP binding site [chemical binding]; other site 1064539014128 Mg2+ binding site [ion binding]; other site 1064539014129 G-X-G motif; other site 1064539014130 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539014131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539014132 active site 1064539014133 phosphorylation site [posttranslational modification] 1064539014134 intermolecular recognition site; other site 1064539014135 dimerization interface [polypeptide binding]; other site 1064539014136 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 1064539014137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539014138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539014139 putative substrate translocation pore; other site 1064539014140 Sporulation related domain; Region: SPOR; pfam05036 1064539014141 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 1064539014142 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1064539014143 homodimer interface [polypeptide binding]; other site 1064539014144 substrate-cofactor binding pocket; other site 1064539014145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539014146 catalytic residue [active] 1064539014147 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1064539014148 enoyl-CoA hydratase; Validated; Region: PRK08139 1064539014149 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539014150 substrate binding site [chemical binding]; other site 1064539014151 oxyanion hole (OAH) forming residues; other site 1064539014152 trimer interface [polypeptide binding]; other site 1064539014153 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1064539014154 CoenzymeA binding site [chemical binding]; other site 1064539014155 subunit interaction site [polypeptide binding]; other site 1064539014156 PHB binding site; other site 1064539014157 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1064539014158 23S rRNA interface [nucleotide binding]; other site 1064539014159 L3 interface [polypeptide binding]; other site 1064539014160 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1064539014161 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1064539014162 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1064539014163 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1064539014164 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1064539014165 trimer interface [polypeptide binding]; other site 1064539014166 putative metal binding site [ion binding]; other site 1064539014167 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1064539014168 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064539014169 ligand binding site [chemical binding]; other site 1064539014170 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1064539014171 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1064539014172 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064539014173 MarR family; Region: MarR; pfam01047 1064539014174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539014175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539014176 putative substrate translocation pore; other site 1064539014177 aminotransferase; Validated; Region: PRK09148 1064539014178 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539014179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539014180 homodimer interface [polypeptide binding]; other site 1064539014181 catalytic residue [active] 1064539014182 homoserine dehydrogenase; Provisional; Region: PRK06349 1064539014183 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1064539014184 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1064539014185 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1064539014186 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1064539014187 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1064539014188 putative active site [active] 1064539014189 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1064539014190 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1064539014191 dimer interface [polypeptide binding]; other site 1064539014192 active site 1064539014193 metal binding site [ion binding]; metal-binding site 1064539014194 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539014195 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1064539014196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1064539014197 Histidine kinase; Region: HisKA_2; pfam07568 1064539014198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539014199 ATP binding site [chemical binding]; other site 1064539014200 Mg2+ binding site [ion binding]; other site 1064539014201 G-X-G motif; other site 1064539014202 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539014203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539014204 non-specific DNA binding site [nucleotide binding]; other site 1064539014205 salt bridge; other site 1064539014206 sequence-specific DNA binding site [nucleotide binding]; other site 1064539014207 potential frameshift: common BLAST hit: gi|288957790|ref|YP_003448131.1| single-stranded-DNA-specific exonuclease 1064539014208 DHH family; Region: DHH; pfam01368 1064539014209 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1064539014210 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1064539014211 catalytic tetrad [active] 1064539014212 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064539014213 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064539014214 active site 1064539014215 catalytic tetrad [active] 1064539014216 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1064539014217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539014218 putative substrate translocation pore; other site 1064539014219 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1064539014220 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1064539014221 putative active site [active] 1064539014222 Zn binding site [ion binding]; other site 1064539014223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539014224 Coenzyme A binding pocket [chemical binding]; other site 1064539014225 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1064539014226 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1064539014227 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1064539014228 FOG: CBS domain [General function prediction only]; Region: COG0517 1064539014229 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1064539014230 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1064539014231 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1064539014232 ligand binding site [chemical binding]; other site 1064539014233 homodimer interface [polypeptide binding]; other site 1064539014234 NAD(P) binding site [chemical binding]; other site 1064539014235 trimer interface B [polypeptide binding]; other site 1064539014236 trimer interface A [polypeptide binding]; other site 1064539014237 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1064539014238 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1064539014239 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1064539014240 FOG: CBS domain [General function prediction only]; Region: COG0517 1064539014241 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1064539014242 BON domain; Region: BON; pfam04972 1064539014243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539014244 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1064539014245 ThiC-associated domain; Region: ThiC-associated; pfam13667 1064539014246 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1064539014247 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1064539014248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539014249 putative substrate translocation pore; other site 1064539014250 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1064539014251 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1064539014252 MOFRL family; Region: MOFRL; pfam05161 1064539014253 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1064539014254 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064539014255 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1064539014256 glyoxylate carboligase; Provisional; Region: PRK11269 1064539014257 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1064539014258 PYR/PP interface [polypeptide binding]; other site 1064539014259 dimer interface [polypeptide binding]; other site 1064539014260 TPP binding site [chemical binding]; other site 1064539014261 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064539014262 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1064539014263 TPP-binding site [chemical binding]; other site 1064539014264 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1064539014265 thiamine phosphate binding site [chemical binding]; other site 1064539014266 active site 1064539014267 pyrophosphate binding site [ion binding]; other site 1064539014268 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539014269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539014270 DNA-binding site [nucleotide binding]; DNA binding site 1064539014271 FCD domain; Region: FCD; pfam07729 1064539014272 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10751408, 1859631, 7592429, 8439398; Product type e : enzyme 1064539014273 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10751408, 1859631, 7592429, 8439398; Product type e : enzyme 1064539014274 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1064539014275 nudix motif; other site 1064539014276 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1064539014277 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1064539014278 FOG: CBS domain [General function prediction only]; Region: COG0517 1064539014279 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1064539014280 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1064539014281 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1064539014282 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1064539014283 trimer interface [polypeptide binding]; other site 1064539014284 putative metal binding site [ion binding]; other site 1064539014285 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 1064539014286 Evidence 2b : Function of strongly homologous gene; PubMedId : 3001057; Product type r : regulator 1064539014287 Evidence 2b : Function of strongly homologous gene; PubMedId : 3001057; Product type r : regulator 1064539014288 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1064539014289 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064539014290 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1064539014291 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1064539014292 proposed catalytic triad [active] 1064539014293 conserved cys residue [active] 1064539014294 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539014295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539014296 active site 1064539014297 intermolecular recognition site; other site 1064539014298 dimerization interface [polypeptide binding]; other site 1064539014299 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539014300 DNA binding residues [nucleotide binding] 1064539014301 dimerization interface [polypeptide binding]; other site 1064539014302 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539014303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539014304 active site 1064539014305 phosphorylation site [posttranslational modification] 1064539014306 intermolecular recognition site; other site 1064539014307 dimerization interface [polypeptide binding]; other site 1064539014308 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539014309 DNA binding residues [nucleotide binding] 1064539014310 dimerization interface [polypeptide binding]; other site 1064539014311 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1064539014312 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064539014313 catalytic loop [active] 1064539014314 iron binding site [ion binding]; other site 1064539014315 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1064539014316 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1064539014317 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1064539014318 UreD urease accessory protein; Region: UreD; pfam01774 1064539014319 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1064539014320 alpha-gamma subunit interface [polypeptide binding]; other site 1064539014321 beta-gamma subunit interface [polypeptide binding]; other site 1064539014322 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1064539014323 gamma-beta subunit interface [polypeptide binding]; other site 1064539014324 alpha-beta subunit interface [polypeptide binding]; other site 1064539014325 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1064539014326 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1064539014327 subunit interactions [polypeptide binding]; other site 1064539014328 active site 1064539014329 flap region; other site 1064539014330 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1064539014331 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1064539014332 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1064539014333 dimer interface [polypeptide binding]; other site 1064539014334 catalytic residues [active] 1064539014335 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1064539014336 UreF; Region: UreF; pfam01730 1064539014337 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1064539014338 G1 box; other site 1064539014339 GTP/Mg2+ binding site [chemical binding]; other site 1064539014340 Switch I region; other site 1064539014341 Switch II region; other site 1064539014342 G3 box; other site 1064539014343 G4 box; other site 1064539014344 G5 box; other site 1064539014345 PRC-barrel domain; Region: PRC; pfam05239 1064539014346 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 1064539014347 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1064539014348 NAD binding site [chemical binding]; other site 1064539014349 homotetramer interface [polypeptide binding]; other site 1064539014350 homodimer interface [polypeptide binding]; other site 1064539014351 substrate binding site [chemical binding]; other site 1064539014352 active site 1064539014353 Hemerythrin; Region: Hemerythrin; cd12107 1064539014354 Fe binding site [ion binding]; other site 1064539014355 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1064539014356 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064539014357 dimerization interface [polypeptide binding]; other site 1064539014358 putative DNA binding site [nucleotide binding]; other site 1064539014359 putative Zn2+ binding site [ion binding]; other site 1064539014360 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 1064539014361 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1064539014362 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1064539014363 putative metal binding site; other site 1064539014364 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539014365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539014366 sequence-specific DNA binding site [nucleotide binding]; other site 1064539014367 salt bridge; other site 1064539014368 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539014369 active site 1064539014370 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1064539014371 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1064539014372 SLBB domain; Region: SLBB; pfam10531 1064539014373 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1064539014374 SprA-related family; Region: SprA-related; pfam12118 1064539014375 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1064539014376 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1064539014377 putative active site; other site 1064539014378 catalytic triad [active] 1064539014379 putative dimer interface [polypeptide binding]; other site 1064539014380 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1064539014381 MarR family; Region: MarR_2; cl17246 1064539014382 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539014383 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539014384 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539014385 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539014386 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539014387 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539014388 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539014389 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539014390 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539014391 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539014392 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539014393 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1064539014394 PhoU domain; Region: PhoU; pfam01895 1064539014395 PhoU domain; Region: PhoU; pfam01895 1064539014396 ChaB; Region: ChaB; cl01887 1064539014397 Evidence 5 : No homology to any previously reported sequences 1064539014398 Evidence 5 : No homology to any previously reported sequences 1064539014399 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539014400 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064539014401 protein binding site [polypeptide binding]; other site 1064539014402 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064539014403 protein binding site [polypeptide binding]; other site 1064539014404 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1064539014405 Ligand binding site; other site 1064539014406 Putative Catalytic site; other site 1064539014407 DXD motif; other site 1064539014408 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 1064539014409 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1064539014410 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1064539014411 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064539014412 nucleotide binding site [chemical binding]; other site 1064539014413 potential frameshift: common BLAST hit: gi|288962874|ref|YP_003453168.1| fructokinase 1064539014414 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1064539014415 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539014416 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539014417 TM-ABC transporter signature motif; other site 1064539014418 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1064539014419 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539014420 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539014421 TM-ABC transporter signature motif; other site 1064539014422 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539014423 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539014424 Walker A/P-loop; other site 1064539014425 ATP binding site [chemical binding]; other site 1064539014426 Q-loop/lid; other site 1064539014427 ABC transporter signature motif; other site 1064539014428 Walker B; other site 1064539014429 D-loop; other site 1064539014430 H-loop/switch region; other site 1064539014431 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539014432 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539014433 Walker A/P-loop; other site 1064539014434 ATP binding site [chemical binding]; other site 1064539014435 Q-loop/lid; other site 1064539014436 ABC transporter signature motif; other site 1064539014437 Walker B; other site 1064539014438 D-loop; other site 1064539014439 H-loop/switch region; other site 1064539014440 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1064539014441 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1064539014442 dimerization interface [polypeptide binding]; other site 1064539014443 ligand binding site [chemical binding]; other site 1064539014444 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1064539014445 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1064539014446 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064539014447 ligand binding site [chemical binding]; other site 1064539014448 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539014449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539014450 active site 1064539014451 phosphorylation site [posttranslational modification] 1064539014452 intermolecular recognition site; other site 1064539014453 dimerization interface [polypeptide binding]; other site 1064539014454 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539014455 DNA binding residues [nucleotide binding] 1064539014456 dimerization interface [polypeptide binding]; other site 1064539014457 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1064539014458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539014459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539014460 dimer interface [polypeptide binding]; other site 1064539014461 phosphorylation site [posttranslational modification] 1064539014462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539014463 ATP binding site [chemical binding]; other site 1064539014464 Mg2+ binding site [ion binding]; other site 1064539014465 G-X-G motif; other site 1064539014466 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1064539014467 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1064539014468 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1064539014469 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1064539014470 active site 1064539014471 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1064539014472 classical (c) SDRs; Region: SDR_c; cd05233 1064539014473 NAD(P) binding site [chemical binding]; other site 1064539014474 active site 1064539014475 amidophosphoribosyltransferase; Provisional; Region: PRK09123 1064539014476 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1064539014477 active site 1064539014478 tetramer interface [polypeptide binding]; other site 1064539014479 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064539014480 active site 1064539014481 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1064539014482 Colicin V production protein; Region: Colicin_V; pfam02674 1064539014483 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1064539014484 KaiC; Region: KaiC; pfam06745 1064539014485 Walker A motif; other site 1064539014486 ATP binding site [chemical binding]; other site 1064539014487 Walker B motif; other site 1064539014488 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1064539014489 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1064539014490 active site 1064539014491 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1064539014492 dimer interface [polypeptide binding]; other site 1064539014493 active site 1064539014494 ADP-ribose binding site [chemical binding]; other site 1064539014495 nudix motif; other site 1064539014496 metal binding site [ion binding]; metal-binding site 1064539014497 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1064539014498 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1064539014499 Walker A/P-loop; other site 1064539014500 ATP binding site [chemical binding]; other site 1064539014501 Q-loop/lid; other site 1064539014502 ABC transporter signature motif; other site 1064539014503 Walker B; other site 1064539014504 D-loop; other site 1064539014505 H-loop/switch region; other site 1064539014506 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1064539014507 Permease; Region: Permease; pfam02405 1064539014508 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1064539014509 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1064539014510 active site 1064539014511 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064539014512 dimer interface [polypeptide binding]; other site 1064539014513 substrate binding site [chemical binding]; other site 1064539014514 catalytic residues [active] 1064539014515 replicative DNA helicase; Provisional; Region: PRK09165 1064539014516 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1064539014517 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1064539014518 Walker A motif; other site 1064539014519 ATP binding site [chemical binding]; other site 1064539014520 Walker B motif; other site 1064539014521 DNA binding loops [nucleotide binding] 1064539014522 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1064539014523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1064539014524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539014525 S-adenosylmethionine binding site [chemical binding]; other site 1064539014526 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1064539014527 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1064539014528 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1064539014529 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1064539014530 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1064539014531 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1064539014532 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1064539014533 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1064539014534 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1064539014535 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1064539014536 NAD(P) binding site [chemical binding]; other site 1064539014537 homotetramer interface [polypeptide binding]; other site 1064539014538 homodimer interface [polypeptide binding]; other site 1064539014539 active site 1064539014540 acyl carrier protein; Provisional; Region: acpP; PRK00982 1064539014541 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1064539014542 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1064539014543 dimer interface [polypeptide binding]; other site 1064539014544 active site 1064539014545 YceG-like family; Region: YceG; pfam02618 1064539014546 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1064539014547 dimerization interface [polypeptide binding]; other site 1064539014548 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1064539014549 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1064539014550 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539014551 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539014552 catalytic residue [active] 1064539014553 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1064539014554 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1064539014555 dimer interface [polypeptide binding]; other site 1064539014556 active site 1064539014557 catalytic residue [active] 1064539014558 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1064539014559 SmpB-tmRNA interface; other site 1064539014560 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1064539014561 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1064539014562 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064539014563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064539014564 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1064539014565 substrate binding site [chemical binding]; other site 1064539014566 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1064539014567 dimer interface [polypeptide binding]; other site 1064539014568 allosteric magnesium binding site [ion binding]; other site 1064539014569 active site 1064539014570 aspartate-rich active site metal binding site; other site 1064539014571 Schiff base residues; other site 1064539014572 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1064539014573 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1064539014574 putative active site [active] 1064539014575 putative metal binding site [ion binding]; other site 1064539014576 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1064539014577 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1064539014578 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1064539014579 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1064539014580 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539014581 substrate binding site [chemical binding]; other site 1064539014582 oxyanion hole (OAH) forming residues; other site 1064539014583 trimer interface [polypeptide binding]; other site 1064539014584 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1064539014585 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1064539014586 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1064539014587 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539014588 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539014589 Walker A/P-loop; other site 1064539014590 ATP binding site [chemical binding]; other site 1064539014591 Q-loop/lid; other site 1064539014592 ABC transporter signature motif; other site 1064539014593 Walker B; other site 1064539014594 D-loop; other site 1064539014595 H-loop/switch region; other site 1064539014596 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539014597 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539014598 Walker A/P-loop; other site 1064539014599 ATP binding site [chemical binding]; other site 1064539014600 Q-loop/lid; other site 1064539014601 ABC transporter signature motif; other site 1064539014602 Walker B; other site 1064539014603 D-loop; other site 1064539014604 H-loop/switch region; other site 1064539014605 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539014606 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539014607 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539014608 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539014609 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539014610 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539014611 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539014612 TM-ABC transporter signature motif; other site 1064539014613 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1064539014614 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1064539014615 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1064539014616 hexamer interface [polypeptide binding]; other site 1064539014617 ligand binding site [chemical binding]; other site 1064539014618 putative active site [active] 1064539014619 NAD(P) binding site [chemical binding]; other site 1064539014620 Phasin protein; Region: Phasin_2; pfam09361 1064539014621 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539014622 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539014623 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1064539014624 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1064539014625 catalytic triad [active] 1064539014626 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1064539014627 putative MPT binding site; other site 1064539014628 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1064539014629 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1064539014630 Ligand binding site; other site 1064539014631 metal-binding site 1064539014632 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1064539014633 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1064539014634 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1064539014635 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1064539014636 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1064539014637 metal ion-dependent adhesion site (MIDAS); other site 1064539014638 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10433972, 7721710; Product type pe : putative enzyme 1064539014639 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10433972, 7721710; Product type pe : putative enzyme 1064539014640 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1064539014641 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1064539014642 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1064539014643 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1064539014644 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1064539014645 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1064539014646 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1064539014647 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1064539014648 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1064539014649 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1064539014650 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1064539014651 DctM-like transporters; Region: DctM; pfam06808 1064539014652 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 1064539014653 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539014654 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 1064539014655 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539014656 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 1064539014657 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 1064539014658 potential frameshift: common BLAST hit: gi|288958333|ref|YP_003448674.1| histone deacetylase 1064539014659 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1064539014660 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1064539014661 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1064539014662 active site 1064539014663 metal binding site [ion binding]; metal-binding site 1064539014664 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1064539014665 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 1064539014666 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1064539014667 cystathionine beta-lyase; Provisional; Region: PRK09028 1064539014668 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1064539014669 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539014670 catalytic residue [active] 1064539014671 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1064539014672 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539014673 substrate binding pocket [chemical binding]; other site 1064539014674 membrane-bound complex binding site; other site 1064539014675 hinge residues; other site 1064539014676 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1064539014677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539014678 conserved gate region; other site 1064539014679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539014680 dimer interface [polypeptide binding]; other site 1064539014681 conserved gate region; other site 1064539014682 putative PBP binding loops; other site 1064539014683 ABC-ATPase subunit interface; other site 1064539014684 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064539014685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539014686 dimer interface [polypeptide binding]; other site 1064539014687 conserved gate region; other site 1064539014688 putative PBP binding loops; other site 1064539014689 ABC-ATPase subunit interface; other site 1064539014690 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1064539014691 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064539014692 Walker A/P-loop; other site 1064539014693 ATP binding site [chemical binding]; other site 1064539014694 Q-loop/lid; other site 1064539014695 ABC transporter signature motif; other site 1064539014696 Walker B; other site 1064539014697 D-loop; other site 1064539014698 H-loop/switch region; other site 1064539014699 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1064539014700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539014701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539014702 homodimer interface [polypeptide binding]; other site 1064539014703 catalytic residue [active] 1064539014704 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539014705 EamA-like transporter family; Region: EamA; pfam00892 1064539014706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539014707 Coenzyme A binding pocket [chemical binding]; other site 1064539014708 putative acetyltransferase; Provisional; Region: PRK03624 1064539014709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539014710 Coenzyme A binding pocket [chemical binding]; other site 1064539014711 3-mercaptopyruvate sulfurtransferase; Region: PLN02723 1064539014712 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1064539014713 active site residue [active] 1064539014714 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1064539014715 active site residue [active] 1064539014716 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1064539014717 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1064539014718 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1064539014719 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1064539014720 dimer interface [polypeptide binding]; other site 1064539014721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539014722 catalytic residue [active] 1064539014723 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1064539014724 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1064539014725 dimer interface [polypeptide binding]; other site 1064539014726 ADP-ribose binding site [chemical binding]; other site 1064539014727 active site 1064539014728 nudix motif; other site 1064539014729 metal binding site [ion binding]; metal-binding site 1064539014730 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1064539014731 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539014732 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064539014733 protein binding site [polypeptide binding]; other site 1064539014734 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1064539014735 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1064539014736 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1064539014737 active site residue [active] 1064539014738 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component 1064539014739 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : putative membrane component 1064539014740 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 1064539014741 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1064539014742 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1064539014743 HIGH motif; other site 1064539014744 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1064539014745 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1064539014746 active site 1064539014747 KMSKS motif; other site 1064539014748 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1064539014749 tRNA binding surface [nucleotide binding]; other site 1064539014750 anticodon binding site; other site 1064539014751 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1064539014752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539014753 dimerization interface [polypeptide binding]; other site 1064539014754 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539014755 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539014756 dimer interface [polypeptide binding]; other site 1064539014757 putative CheW interface [polypeptide binding]; other site 1064539014758 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1064539014759 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1064539014760 putative active site [active] 1064539014761 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein 1064539014762 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein 1064539014763 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1064539014764 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1064539014765 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1064539014766 thymidylate kinase; Validated; Region: tmk; PRK00698 1064539014767 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1064539014768 TMP-binding site; other site 1064539014769 ATP-binding site [chemical binding]; other site 1064539014770 DNA polymerase III subunit delta'; Validated; Region: PRK07471 1064539014771 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1064539014772 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1064539014773 active site 1064539014774 HIGH motif; other site 1064539014775 KMSKS motif; other site 1064539014776 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1064539014777 tRNA binding surface [nucleotide binding]; other site 1064539014778 anticodon binding site; other site 1064539014779 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1064539014780 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1064539014781 active site 1064539014782 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1064539014783 putative hydrolase; Provisional; Region: PRK02113 1064539014784 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1064539014785 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1064539014786 Protein phosphatase 2C; Region: PP2C; pfam00481 1064539014787 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1064539014788 active site 1064539014789 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1064539014790 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1064539014791 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064539014792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539014793 dimer interface [polypeptide binding]; other site 1064539014794 conserved gate region; other site 1064539014795 putative PBP binding loops; other site 1064539014796 ABC-ATPase subunit interface; other site 1064539014797 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1064539014798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539014799 dimer interface [polypeptide binding]; other site 1064539014800 conserved gate region; other site 1064539014801 putative PBP binding loops; other site 1064539014802 ABC-ATPase subunit interface; other site 1064539014803 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1064539014804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539014805 Walker A/P-loop; other site 1064539014806 ATP binding site [chemical binding]; other site 1064539014807 Q-loop/lid; other site 1064539014808 ABC transporter signature motif; other site 1064539014809 Walker B; other site 1064539014810 D-loop; other site 1064539014811 H-loop/switch region; other site 1064539014812 TOBE domain; Region: TOBE_2; pfam08402 1064539014813 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1064539014814 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539014815 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1064539014816 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1064539014817 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1064539014818 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1064539014819 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1064539014820 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1064539014821 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1064539014822 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1064539014823 FAD binding pocket [chemical binding]; other site 1064539014824 FAD binding motif [chemical binding]; other site 1064539014825 phosphate binding motif [ion binding]; other site 1064539014826 beta-alpha-beta structure motif; other site 1064539014827 NAD binding pocket [chemical binding]; other site 1064539014828 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1064539014829 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1064539014830 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1064539014831 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1064539014832 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1064539014833 IHF - DNA interface [nucleotide binding]; other site 1064539014834 IHF dimer interface [polypeptide binding]; other site 1064539014835 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1064539014836 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1064539014837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539014838 Coenzyme A binding pocket [chemical binding]; other site 1064539014839 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1064539014840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539014841 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1064539014842 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1064539014843 heme-binding site [chemical binding]; other site 1064539014844 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539014845 dimer interface [polypeptide binding]; other site 1064539014846 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1064539014847 putative CheW interface [polypeptide binding]; other site 1064539014848 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1064539014849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539014850 Coenzyme A binding pocket [chemical binding]; other site 1064539014851 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1064539014852 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1064539014853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1064539014854 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1064539014855 MoaE homodimer interface [polypeptide binding]; other site 1064539014856 MoaD interaction [polypeptide binding]; other site 1064539014857 active site residues [active] 1064539014858 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1064539014859 MoaE interaction surface [polypeptide binding]; other site 1064539014860 MoeB interaction surface [polypeptide binding]; other site 1064539014861 thiocarboxylated glycine; other site 1064539014862 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1064539014863 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1064539014864 dimer interface [polypeptide binding]; other site 1064539014865 putative functional site; other site 1064539014866 putative MPT binding site; other site 1064539014867 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1064539014868 Walker A motif; other site 1064539014869 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1064539014870 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1064539014871 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1064539014872 GIY-YIG motif/motif A; other site 1064539014873 active site 1064539014874 catalytic site [active] 1064539014875 putative DNA binding site [nucleotide binding]; other site 1064539014876 metal binding site [ion binding]; metal-binding site 1064539014877 UvrB/uvrC motif; Region: UVR; pfam02151 1064539014878 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1064539014879 short chain dehydrogenase; Provisional; Region: PRK09134 1064539014880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539014881 NAD(P) binding site [chemical binding]; other site 1064539014882 active site 1064539014883 Flagellin N-methylase; Region: FliB; pfam03692 1064539014884 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1064539014885 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1064539014886 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1064539014887 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1064539014888 TPP-binding site [chemical binding]; other site 1064539014889 dimer interface [polypeptide binding]; other site 1064539014890 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1064539014891 PYR/PP interface [polypeptide binding]; other site 1064539014892 dimer interface [polypeptide binding]; other site 1064539014893 TPP binding site [chemical binding]; other site 1064539014894 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064539014895 Cell division protein ZapA; Region: ZapA; pfam05164 1064539014896 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1064539014897 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1064539014898 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1064539014899 putative active site [active] 1064539014900 metal binding site [ion binding]; metal-binding site 1064539014901 homodimer binding site [polypeptide binding]; other site 1064539014902 hypothetical protein; Validated; Region: PRK00110 1064539014903 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1064539014904 active site 1064539014905 putative DNA-binding cleft [nucleotide binding]; other site 1064539014906 dimer interface [polypeptide binding]; other site 1064539014907 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1064539014908 putative active site [active] 1064539014909 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1064539014910 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1064539014911 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1064539014912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539014913 Walker A motif; other site 1064539014914 ATP binding site [chemical binding]; other site 1064539014915 Walker B motif; other site 1064539014916 arginine finger; other site 1064539014917 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1064539014918 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1064539014919 active site 1064539014920 TolQ protein; Region: tolQ; TIGR02796 1064539014921 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1064539014922 TolR protein; Region: tolR; TIGR02801 1064539014923 translocation protein TolB; Provisional; Region: tolB; PRK05137 1064539014924 TolB amino-terminal domain; Region: TolB_N; pfam04052 1064539014925 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1064539014926 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1064539014927 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1064539014928 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064539014929 ligand binding site [chemical binding]; other site 1064539014930 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1064539014931 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1064539014932 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1064539014933 NAD(P) binding site [chemical binding]; other site 1064539014934 homodimer interface [polypeptide binding]; other site 1064539014935 substrate binding site [chemical binding]; other site 1064539014936 active site 1064539014937 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539014938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539014939 NAD(P) binding site [chemical binding]; other site 1064539014940 active site 1064539014941 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1064539014942 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1064539014943 Mg++ binding site [ion binding]; other site 1064539014944 putative catalytic motif [active] 1064539014945 putative substrate binding site [chemical binding]; other site 1064539014946 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1064539014947 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539014948 putative ADP-binding pocket [chemical binding]; other site 1064539014949 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539014950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539014951 NAD(P) binding site [chemical binding]; other site 1064539014952 active site 1064539014953 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10498721; Product type pe : putative enzyme 1064539014954 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10498721; Product type pe : putative enzyme 1064539014955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539014956 FeS/SAM binding site; other site 1064539014957 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1064539014958 EamA-like transporter family; Region: EamA; pfam00892 1064539014959 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1064539014960 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1064539014961 hinge; other site 1064539014962 active site 1064539014963 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 1064539014964 OsmC-like protein; Region: OsmC; cl00767 1064539014965 short chain dehydrogenase; Provisional; Region: PRK07109 1064539014966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539014967 NAD(P) binding site [chemical binding]; other site 1064539014968 active site 1064539014969 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1064539014970 Arabidopsis phospholipase-like protein (PEARLI 4); Region: PEARLI-4; pfam05278 1064539014971 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1064539014972 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1064539014973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539014974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539014975 dimer interface [polypeptide binding]; other site 1064539014976 phosphorylation site [posttranslational modification] 1064539014977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539014978 ATP binding site [chemical binding]; other site 1064539014979 G-X-G motif; other site 1064539014980 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 1064539014981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539014982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539014983 ATP binding site [chemical binding]; other site 1064539014984 Mg2+ binding site [ion binding]; other site 1064539014985 G-X-G motif; other site 1064539014986 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539014987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539014988 active site 1064539014989 phosphorylation site [posttranslational modification] 1064539014990 intermolecular recognition site; other site 1064539014991 dimerization interface [polypeptide binding]; other site 1064539014992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539014993 DNA binding site [nucleotide binding] 1064539014994 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539014995 dimerization interface [polypeptide binding]; other site 1064539014996 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1064539014997 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1064539014998 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539014999 substrate binding pocket [chemical binding]; other site 1064539015000 membrane-bound complex binding site; other site 1064539015001 hinge residues; other site 1064539015002 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1064539015003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539015004 Walker A motif; other site 1064539015005 ATP binding site [chemical binding]; other site 1064539015006 Walker B motif; other site 1064539015007 arginine finger; other site 1064539015008 Peptidase family M41; Region: Peptidase_M41; pfam01434 1064539015009 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 1064539015010 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 1064539015011 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 1064539015012 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1064539015013 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1064539015014 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1064539015015 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1064539015016 Cation efflux family; Region: Cation_efflux; cl00316 1064539015017 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539015018 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539015019 dimer interface [polypeptide binding]; other site 1064539015020 putative CheW interface [polypeptide binding]; other site 1064539015021 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539015022 putative CheW interface [polypeptide binding]; other site 1064539015023 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1064539015024 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1064539015025 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1064539015026 transmembrane helices; other site 1064539015027 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1064539015028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539015029 active site 1064539015030 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1064539015031 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539015032 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1064539015033 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1064539015034 metal binding site 2 [ion binding]; metal-binding site 1064539015035 putative DNA binding helix; other site 1064539015036 metal binding site 1 [ion binding]; metal-binding site 1064539015037 dimer interface [polypeptide binding]; other site 1064539015038 structural Zn2+ binding site [ion binding]; other site 1064539015039 Evidence 4 : Homologs of previously reported genes of unknown function 1064539015040 Evidence 4 : Homologs of previously reported genes of unknown function 1064539015041 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1064539015042 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064539015043 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1064539015044 Fasciclin domain; Region: Fasciclin; pfam02469 1064539015045 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1064539015046 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 1064539015047 putative active site [active] 1064539015048 putative metal binding site [ion binding]; other site 1064539015049 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 1064539015050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064539015051 ATP binding site [chemical binding]; other site 1064539015052 putative Mg++ binding site [ion binding]; other site 1064539015053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539015054 nucleotide binding region [chemical binding]; other site 1064539015055 ATP-binding site [chemical binding]; other site 1064539015056 DEAD/H associated; Region: DEAD_assoc; pfam08494 1064539015057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1064539015058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1064539015059 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1064539015060 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1064539015061 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1064539015062 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1064539015063 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064539015064 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539015065 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539015066 ligand binding site [chemical binding]; other site 1064539015067 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1064539015068 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1064539015069 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 1064539015070 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1064539015071 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1064539015072 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1064539015073 ligand binding site [chemical binding]; other site 1064539015074 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1064539015075 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064539015076 ligand binding site [chemical binding]; other site 1064539015077 Protein of unknown function (DUF1150); Region: DUF1150; cl11577 1064539015078 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1064539015079 CHASE2 domain; Region: CHASE2; pfam05226 1064539015080 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1064539015081 cyclase homology domain; Region: CHD; cd07302 1064539015082 nucleotidyl binding site; other site 1064539015083 metal binding site [ion binding]; metal-binding site 1064539015084 dimer interface [polypeptide binding]; other site 1064539015085 Caspase domain; Region: Peptidase_C14; pfam00656 1064539015086 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 1064539015087 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1064539015088 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1064539015089 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539015090 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539015091 ligand binding site [chemical binding]; other site 1064539015092 flexible hinge region; other site 1064539015093 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1064539015094 putative switch regulator; other site 1064539015095 non-specific DNA interactions [nucleotide binding]; other site 1064539015096 DNA binding site [nucleotide binding] 1064539015097 sequence specific DNA binding site [nucleotide binding]; other site 1064539015098 putative cAMP binding site [chemical binding]; other site 1064539015099 acyl-CoA synthetase; Validated; Region: PRK08162 1064539015100 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1064539015101 acyl-activating enzyme (AAE) consensus motif; other site 1064539015102 putative active site [active] 1064539015103 AMP binding site [chemical binding]; other site 1064539015104 putative CoA binding site [chemical binding]; other site 1064539015105 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1064539015106 classical (c) SDRs; Region: SDR_c; cd05233 1064539015107 NAD(P) binding site [chemical binding]; other site 1064539015108 active site 1064539015109 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539015110 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064539015111 active site 1064539015112 potential frameshift: common BLAST hit: gi|288958424|ref|YP_003448765.1| aminoglycoside phosphotransferase 1064539015113 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1064539015114 putative active site [active] 1064539015115 putative substrate binding site [chemical binding]; other site 1064539015116 ATP binding site [chemical binding]; other site 1064539015117 Phosphotransferase enzyme family; Region: APH; pfam01636 1064539015118 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1064539015119 dinuclear metal binding motif [ion binding]; other site 1064539015120 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1064539015121 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1064539015122 active site 1064539015123 Hemerythrin; Region: Hemerythrin; cd12107 1064539015124 Fe binding site [ion binding]; other site 1064539015125 trehalose synthase; Region: treS_nterm; TIGR02456 1064539015126 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1064539015127 active site 1064539015128 catalytic site [active] 1064539015129 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1064539015130 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1064539015131 glycogen branching enzyme; Provisional; Region: PRK05402 1064539015132 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1064539015133 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1064539015134 active site 1064539015135 catalytic site [active] 1064539015136 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1064539015137 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1064539015138 active site 1064539015139 NTP binding site [chemical binding]; other site 1064539015140 metal binding triad [ion binding]; metal-binding site 1064539015141 antibiotic binding site [chemical binding]; other site 1064539015142 Protein of unknown function DUF86; Region: DUF86; cl01031 1064539015143 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1064539015144 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1064539015145 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1064539015146 active site 1064539015147 catalytic site [active] 1064539015148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539015149 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539015150 active site 1064539015151 phosphorylation site [posttranslational modification] 1064539015152 dimerization interface [polypeptide binding]; other site 1064539015153 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1064539015154 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1064539015155 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1064539015156 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1064539015157 heme binding site [chemical binding]; other site 1064539015158 ferroxidase pore; other site 1064539015159 ferroxidase diiron center [ion binding]; other site 1064539015160 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1064539015161 active site 1064539015162 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 1064539015163 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1064539015164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539015165 Walker A/P-loop; other site 1064539015166 ATP binding site [chemical binding]; other site 1064539015167 Q-loop/lid; other site 1064539015168 ABC transporter signature motif; other site 1064539015169 Walker B; other site 1064539015170 D-loop; other site 1064539015171 H-loop/switch region; other site 1064539015172 ABC transporter; Region: ABC_tran_2; pfam12848 1064539015173 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064539015174 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1064539015175 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015176 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015177 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1064539015178 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015179 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015180 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015181 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015182 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1064539015183 VacJ like lipoprotein; Region: VacJ; cl01073 1064539015184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064539015185 Predicted transcriptional regulator [Transcription]; Region: COG2345 1064539015186 putative DNA binding site [nucleotide binding]; other site 1064539015187 putative Zn2+ binding site [ion binding]; other site 1064539015188 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1064539015189 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1064539015190 FAD binding site [chemical binding]; other site 1064539015191 Domain of unknown function DUF29; Region: DUF29; pfam01724 1064539015192 potential frameshift: common BLAST hit: gi|374291323|ref|YP_005038358.1| B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase 1064539015193 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1064539015194 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1064539015195 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 1064539015196 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1064539015197 substrate binding pocket [chemical binding]; other site 1064539015198 dimer interface [polypeptide binding]; other site 1064539015199 inhibitor binding site; inhibition site 1064539015200 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1064539015201 B12 binding site [chemical binding]; other site 1064539015202 cobalt ligand [ion binding]; other site 1064539015203 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1064539015204 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1064539015205 active site 1064539015206 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539015207 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015208 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015209 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015210 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539015211 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539015212 metal binding site [ion binding]; metal-binding site 1064539015213 active site 1064539015214 I-site; other site 1064539015215 Nitronate monooxygenase; Region: NMO; pfam03060 1064539015216 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1064539015217 FMN binding site [chemical binding]; other site 1064539015218 substrate binding site [chemical binding]; other site 1064539015219 putative catalytic residue [active] 1064539015220 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1064539015221 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1064539015222 putative [4Fe-4S] binding site [ion binding]; other site 1064539015223 putative molybdopterin cofactor binding site [chemical binding]; other site 1064539015224 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1064539015225 molybdopterin cofactor binding site; other site 1064539015226 HAMP domain; Region: HAMP; pfam00672 1064539015227 dimerization interface [polypeptide binding]; other site 1064539015228 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539015229 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539015230 dimer interface [polypeptide binding]; other site 1064539015231 putative CheW interface [polypeptide binding]; other site 1064539015232 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1064539015233 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1064539015234 PhnA protein; Region: PhnA; pfam03831 1064539015235 DctM-like transporters; Region: DctM; pfam06808 1064539015236 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1064539015237 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1064539015238 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539015239 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539015240 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8455557, 11803016; Product type e : enzyme 1064539015241 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8455557, 11803016; Product type e : enzyme 1064539015242 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1064539015243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539015244 active site 1064539015245 phosphorylation site [posttranslational modification] 1064539015246 intermolecular recognition site; other site 1064539015247 dimerization interface [polypeptide binding]; other site 1064539015248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539015249 DNA binding residues [nucleotide binding] 1064539015250 dimerization interface [polypeptide binding]; other site 1064539015251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539015252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539015253 dimer interface [polypeptide binding]; other site 1064539015254 phosphorylation site [posttranslational modification] 1064539015255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539015256 ATP binding site [chemical binding]; other site 1064539015257 Mg2+ binding site [ion binding]; other site 1064539015258 G-X-G motif; other site 1064539015259 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1064539015260 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1064539015261 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1064539015262 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1064539015263 hypothetical protein; Provisional; Region: PRK10279 1064539015264 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1064539015265 active site 1064539015266 nucleophile elbow; other site 1064539015267 LysE type translocator; Region: LysE; cl00565 1064539015268 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1064539015269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064539015270 putative DNA binding site [nucleotide binding]; other site 1064539015271 putative Zn2+ binding site [ion binding]; other site 1064539015272 AsnC family; Region: AsnC_trans_reg; pfam01037 1064539015273 Rubredoxin; Region: Rubredoxin; pfam00301 1064539015274 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1064539015275 iron binding site [ion binding]; other site 1064539015276 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015277 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1064539015278 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015279 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015280 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015281 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015282 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539015283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1064539015284 Peptidase M15; Region: Peptidase_M15_3; cl01194 1064539015285 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1064539015286 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1064539015287 glutaminase active site [active] 1064539015288 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1064539015289 dimer interface [polypeptide binding]; other site 1064539015290 active site 1064539015291 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1064539015292 dimer interface [polypeptide binding]; other site 1064539015293 active site 1064539015294 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 1064539015295 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1064539015296 Substrate binding site; other site 1064539015297 Mg++ binding site; other site 1064539015298 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1064539015299 active site 1064539015300 substrate binding site [chemical binding]; other site 1064539015301 CoA binding site [chemical binding]; other site 1064539015302 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1064539015303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1064539015304 motif I; other site 1064539015305 active site 1064539015306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539015307 motif II; other site 1064539015308 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1064539015309 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1064539015310 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1064539015311 active site 1064539015312 ATP-binding site [chemical binding]; other site 1064539015313 pantoate-binding site; other site 1064539015314 HXXH motif; other site 1064539015315 succinic semialdehyde dehydrogenase; Region: PLN02278 1064539015316 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1064539015317 tetramerization interface [polypeptide binding]; other site 1064539015318 NAD(P) binding site [chemical binding]; other site 1064539015319 catalytic residues [active] 1064539015320 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1064539015321 muropeptide transporter; Validated; Region: ampG; cl17669 1064539015322 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1064539015323 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1064539015324 dimanganese center [ion binding]; other site 1064539015325 glutathione reductase; Validated; Region: PRK06116 1064539015326 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539015327 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1064539015328 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1064539015329 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1064539015330 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 1064539015331 active site 1064539015332 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1064539015333 dimer interface [polypeptide binding]; other site 1064539015334 [2Fe-2S] cluster binding site [ion binding]; other site 1064539015335 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1064539015336 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1064539015337 enoyl-CoA hydratase; Provisional; Region: PRK05980 1064539015338 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539015339 substrate binding site [chemical binding]; other site 1064539015340 oxyanion hole (OAH) forming residues; other site 1064539015341 trimer interface [polypeptide binding]; other site 1064539015342 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1064539015343 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1064539015344 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1064539015345 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064539015346 ATP binding site [chemical binding]; other site 1064539015347 putative Mg++ binding site [ion binding]; other site 1064539015348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539015349 nucleotide binding region [chemical binding]; other site 1064539015350 ATP-binding site [chemical binding]; other site 1064539015351 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1064539015352 Family description; Region: ACT_7; pfam13840 1064539015353 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1064539015354 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1064539015355 PRC-barrel domain; Region: PRC; pfam05239 1064539015356 hypothetical protein; Provisional; Region: PRK09256 1064539015357 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1064539015358 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1064539015359 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1064539015360 catalytic residues [active] 1064539015361 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 1064539015362 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1064539015363 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1064539015364 homotrimer interface [polypeptide binding]; other site 1064539015365 Walker A motif; other site 1064539015366 GTP binding site [chemical binding]; other site 1064539015367 Walker B motif; other site 1064539015368 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1064539015369 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1064539015370 homodimer interface [polypeptide binding]; other site 1064539015371 Walker A motif; other site 1064539015372 ATP binding site [chemical binding]; other site 1064539015373 hydroxycobalamin binding site [chemical binding]; other site 1064539015374 Walker B motif; other site 1064539015375 cobyric acid synthase; Provisional; Region: PRK00784 1064539015376 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539015377 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1064539015378 catalytic triad [active] 1064539015379 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1064539015380 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1064539015381 generic binding surface II; other site 1064539015382 ssDNA binding site; other site 1064539015383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064539015384 ATP binding site [chemical binding]; other site 1064539015385 putative Mg++ binding site [ion binding]; other site 1064539015386 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539015387 nucleotide binding region [chemical binding]; other site 1064539015388 ATP-binding site [chemical binding]; other site 1064539015389 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1064539015390 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1064539015391 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1064539015392 malonyl-CoA binding site [chemical binding]; other site 1064539015393 dimer interface [polypeptide binding]; other site 1064539015394 active site 1064539015395 product binding site; other site 1064539015396 Phospholipid methyltransferase; Region: PEMT; cl17370 1064539015397 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539015398 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539015399 ligand binding site [chemical binding]; other site 1064539015400 flexible hinge region; other site 1064539015401 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1064539015402 putative switch regulator; other site 1064539015403 non-specific DNA interactions [nucleotide binding]; other site 1064539015404 DNA binding site [nucleotide binding] 1064539015405 sequence specific DNA binding site [nucleotide binding]; other site 1064539015406 putative cAMP binding site [chemical binding]; other site 1064539015407 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539015408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1064539015409 active site 1064539015410 phosphorylation site [posttranslational modification] 1064539015411 intermolecular recognition site; other site 1064539015412 dimerization interface [polypeptide binding]; other site 1064539015413 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539015414 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539015415 ligand binding site [chemical binding]; other site 1064539015416 flexible hinge region; other site 1064539015417 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1064539015418 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1064539015419 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1064539015420 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 1064539015421 Ligand binding site; other site 1064539015422 DXD motif; other site 1064539015423 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1064539015424 HIT family signature motif; other site 1064539015425 catalytic residue [active] 1064539015426 CsbD-like; Region: CsbD; cl17424 1064539015427 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 1064539015428 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1064539015429 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1064539015430 G1 box; other site 1064539015431 putative GEF interaction site [polypeptide binding]; other site 1064539015432 GTP/Mg2+ binding site [chemical binding]; other site 1064539015433 Switch I region; other site 1064539015434 G2 box; other site 1064539015435 G3 box; other site 1064539015436 Switch II region; other site 1064539015437 G4 box; other site 1064539015438 G5 box; other site 1064539015439 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1064539015440 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1064539015441 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1064539015442 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1064539015443 Surface antigen; Region: Bac_surface_Ag; pfam01103 1064539015444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1064539015445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1064539015446 Family of unknown function (DUF490); Region: DUF490; pfam04357 1064539015447 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1064539015448 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 1064539015449 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1064539015450 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1064539015451 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064539015452 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 1064539015453 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 1064539015454 active site 1064539015455 DNA binding site [nucleotide binding] 1064539015456 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1064539015457 DNA binding site [nucleotide binding] 1064539015458 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1064539015459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539015460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1064539015461 Coenzyme A binding pocket [chemical binding]; other site 1064539015462 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1064539015463 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1064539015464 dimerization interface [polypeptide binding]; other site 1064539015465 metal binding site [ion binding]; metal-binding site 1064539015466 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1064539015467 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1064539015468 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1064539015469 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1064539015470 dimer interface [polypeptide binding]; other site 1064539015471 active site 1064539015472 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1064539015473 folate binding site [chemical binding]; other site 1064539015474 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1064539015475 ATP cone domain; Region: ATP-cone; pfam03477 1064539015476 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1064539015477 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1064539015478 catalytic motif [active] 1064539015479 Zn binding site [ion binding]; other site 1064539015480 RibD C-terminal domain; Region: RibD_C; cl17279 1064539015481 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1064539015482 Lumazine binding domain; Region: Lum_binding; pfam00677 1064539015483 Lumazine binding domain; Region: Lum_binding; pfam00677 1064539015484 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1064539015485 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1064539015486 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1064539015487 dimerization interface [polypeptide binding]; other site 1064539015488 active site 1064539015489 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1064539015490 homopentamer interface [polypeptide binding]; other site 1064539015491 active site 1064539015492 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1064539015493 thiamine monophosphate kinase; Provisional; Region: PRK05731 1064539015494 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1064539015495 ATP binding site [chemical binding]; other site 1064539015496 dimerization interface [polypeptide binding]; other site 1064539015497 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1064539015498 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1064539015499 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1064539015500 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1064539015501 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981 1064539015502 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1064539015503 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1064539015504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1064539015505 putative phosphate acyltransferase; Provisional; Region: PRK05331 1064539015506 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1064539015507 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1064539015508 dimer interface [polypeptide binding]; other site 1064539015509 active site 1064539015510 CoA binding pocket [chemical binding]; other site 1064539015511 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1064539015512 IHF dimer interface [polypeptide binding]; other site 1064539015513 IHF - DNA interface [nucleotide binding]; other site 1064539015514 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1064539015515 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1064539015516 DNA binding residues [nucleotide binding] 1064539015517 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1064539015518 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1064539015519 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539015520 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539015521 ligand binding site [chemical binding]; other site 1064539015522 flexible hinge region; other site 1064539015523 elongation factor EF-2; Reviewed; Region: PRK07560 1064539015524 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1064539015525 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1064539015526 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1064539015527 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1064539015528 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 1064539015529 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 1064539015530 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme 1064539015531 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1064539015532 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1064539015533 Active Sites [active] 1064539015534 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1064539015535 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1064539015536 Active Sites [active] 1064539015537 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1064539015538 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1064539015539 CysD dimerization site [polypeptide binding]; other site 1064539015540 G1 box; other site 1064539015541 putative GEF interaction site [polypeptide binding]; other site 1064539015542 GTP/Mg2+ binding site [chemical binding]; other site 1064539015543 Switch I region; other site 1064539015544 G2 box; other site 1064539015545 G3 box; other site 1064539015546 Switch II region; other site 1064539015547 G4 box; other site 1064539015548 G5 box; other site 1064539015549 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1064539015550 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1064539015551 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1064539015552 ligand-binding site [chemical binding]; other site 1064539015553 NMT1-like family; Region: NMT1_2; pfam13379 1064539015554 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1064539015555 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539015556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539015557 dimer interface [polypeptide binding]; other site 1064539015558 conserved gate region; other site 1064539015559 putative PBP binding loops; other site 1064539015560 ABC-ATPase subunit interface; other site 1064539015561 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539015562 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539015563 Walker A/P-loop; other site 1064539015564 ATP binding site [chemical binding]; other site 1064539015565 Q-loop/lid; other site 1064539015566 ABC transporter signature motif; other site 1064539015567 Walker B; other site 1064539015568 D-loop; other site 1064539015569 H-loop/switch region; other site 1064539015570 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1064539015571 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539015572 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539015573 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1064539015574 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1064539015575 DNA binding residues [nucleotide binding] 1064539015576 putative dimer interface [polypeptide binding]; other site 1064539015577 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1064539015578 active site 1064539015579 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1064539015580 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1064539015581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539015582 putative substrate translocation pore; other site 1064539015583 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1064539015584 Cupin domain; Region: Cupin_2; pfam07883 1064539015585 Hemerythrin; Region: Hemerythrin; cd12107 1064539015586 Hemerythrin; Region: Hemerythrin; cd12107 1064539015587 Fe binding site [ion binding]; other site 1064539015588 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1064539015589 dimer interface [polypeptide binding]; other site 1064539015590 active site 1064539015591 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064539015592 catalytic residues [active] 1064539015593 substrate binding site [chemical binding]; other site 1064539015594 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 1064539015595 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1064539015596 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1064539015597 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1064539015598 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1064539015599 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539015600 catalytic residue [active] 1064539015601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539015602 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539015603 putative active site [active] 1064539015604 heme pocket [chemical binding]; other site 1064539015605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539015606 putative active site [active] 1064539015607 heme pocket [chemical binding]; other site 1064539015608 PAS domain S-box; Region: sensory_box; TIGR00229 1064539015609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539015610 putative active site [active] 1064539015611 heme pocket [chemical binding]; other site 1064539015612 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539015613 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539015614 metal binding site [ion binding]; metal-binding site 1064539015615 active site 1064539015616 I-site; other site 1064539015617 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539015618 PAS domain; Region: PAS_9; pfam13426 1064539015619 putative active site [active] 1064539015620 heme pocket [chemical binding]; other site 1064539015621 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539015622 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539015623 dimer interface [polypeptide binding]; other site 1064539015624 putative CheW interface [polypeptide binding]; other site 1064539015625 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539015626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539015627 putative active site [active] 1064539015628 heme pocket [chemical binding]; other site 1064539015629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539015630 dimer interface [polypeptide binding]; other site 1064539015631 phosphorylation site [posttranslational modification] 1064539015632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539015633 ATP binding site [chemical binding]; other site 1064539015634 Mg2+ binding site [ion binding]; other site 1064539015635 G-X-G motif; other site 1064539015636 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539015637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539015638 active site 1064539015639 phosphorylation site [posttranslational modification] 1064539015640 intermolecular recognition site; other site 1064539015641 dimerization interface [polypeptide binding]; other site 1064539015642 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539015643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539015644 active site 1064539015645 phosphorylation site [posttranslational modification] 1064539015646 intermolecular recognition site; other site 1064539015647 dimerization interface [polypeptide binding]; other site 1064539015648 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064539015649 putative binding surface; other site 1064539015650 active site 1064539015651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539015652 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539015653 substrate binding pocket [chemical binding]; other site 1064539015654 membrane-bound complex binding site; other site 1064539015655 hinge residues; other site 1064539015656 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1064539015657 potassium uptake protein; Region: kup; TIGR00794 1064539015658 Archaeal ATPase; Region: Arch_ATPase; pfam01637 1064539015659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539015660 Walker A motif; other site 1064539015661 ATP binding site [chemical binding]; other site 1064539015662 Walker B motif; other site 1064539015663 arginine finger; other site 1064539015664 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539015665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539015666 active site 1064539015667 phosphorylation site [posttranslational modification] 1064539015668 intermolecular recognition site; other site 1064539015669 dimerization interface [polypeptide binding]; other site 1064539015670 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539015671 DNA binding residues [nucleotide binding] 1064539015672 dimerization interface [polypeptide binding]; other site 1064539015673 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539015674 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539015675 DNA binding residues [nucleotide binding] 1064539015676 dimerization interface [polypeptide binding]; other site 1064539015677 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539015678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539015679 active site 1064539015680 phosphorylation site [posttranslational modification] 1064539015681 intermolecular recognition site; other site 1064539015682 dimerization interface [polypeptide binding]; other site 1064539015683 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539015684 DNA binding residues [nucleotide binding] 1064539015685 dimerization interface [polypeptide binding]; other site 1064539015686 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1064539015687 putative catalytic residue [active] 1064539015688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 1064539015689 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1064539015690 Trp docking motif [polypeptide binding]; other site 1064539015691 active site 1064539015692 PQQ-like domain; Region: PQQ_2; pfam13360 1064539015693 GTP-binding protein Der; Reviewed; Region: PRK00093 1064539015694 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1064539015695 G1 box; other site 1064539015696 GTP/Mg2+ binding site [chemical binding]; other site 1064539015697 Switch I region; other site 1064539015698 G2 box; other site 1064539015699 Switch II region; other site 1064539015700 G3 box; other site 1064539015701 G4 box; other site 1064539015702 G5 box; other site 1064539015703 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1064539015704 G1 box; other site 1064539015705 GTP/Mg2+ binding site [chemical binding]; other site 1064539015706 Switch I region; other site 1064539015707 G2 box; other site 1064539015708 G3 box; other site 1064539015709 Switch II region; other site 1064539015710 G4 box; other site 1064539015711 G5 box; other site 1064539015712 fumarate hydratase; Provisional; Region: PRK15389 1064539015713 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1064539015714 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1064539015715 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 1064539015716 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1064539015717 acyl-activating enzyme (AAE) consensus motif; other site 1064539015718 AMP binding site [chemical binding]; other site 1064539015719 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1064539015720 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1064539015721 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1064539015722 putative trimer interface [polypeptide binding]; other site 1064539015723 putative CoA binding site [chemical binding]; other site 1064539015724 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1064539015725 putative trimer interface [polypeptide binding]; other site 1064539015726 putative CoA binding site [chemical binding]; other site 1064539015727 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1064539015728 putative trimer interface [polypeptide binding]; other site 1064539015729 putative CoA binding site [chemical binding]; other site 1064539015730 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 1064539015731 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539015732 active site 1064539015733 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1064539015734 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 1064539015735 putative acyl-acceptor binding pocket; other site 1064539015736 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064539015737 phytoene desaturase; Region: crtI_fam; TIGR02734 1064539015738 phytoene desaturase; Region: crtI_fam; TIGR02734 1064539015739 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1064539015740 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064539015741 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1064539015742 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1064539015743 NAD(P) binding site [chemical binding]; other site 1064539015744 potential frameshift: common BLAST hit: gi|374998579|ref|YP_004974078.1| putative aldehyde dehydrogenase (NAD+) 1064539015745 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1064539015746 catalytic residues [active] 1064539015747 Predicted membrane protein [Function unknown]; Region: COG3918 1064539015748 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064539015749 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1064539015750 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1064539015751 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1064539015752 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1064539015753 HicB family; Region: HicB; pfam05534 1064539015754 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1064539015755 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1064539015756 putative active site; other site 1064539015757 catalytic residue [active] 1064539015758 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1064539015759 thiamine phosphate binding site [chemical binding]; other site 1064539015760 active site 1064539015761 pyrophosphate binding site [ion binding]; other site 1064539015762 hypothetical protein; Provisional; Region: PRK10621 1064539015763 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1064539015764 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 1064539015765 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1064539015766 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1064539015767 NADP binding site [chemical binding]; other site 1064539015768 dimer interface [polypeptide binding]; other site 1064539015769 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1064539015770 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1064539015771 motif 1; other site 1064539015772 dimer interface [polypeptide binding]; other site 1064539015773 active site 1064539015774 motif 2; other site 1064539015775 motif 3; other site 1064539015776 elongation factor P; Validated; Region: PRK00529 1064539015777 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1064539015778 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1064539015779 RNA binding site [nucleotide binding]; other site 1064539015780 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1064539015781 RNA binding site [nucleotide binding]; other site 1064539015782 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1064539015783 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1064539015784 active site 1064539015785 dimerization interface [polypeptide binding]; other site 1064539015786 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1064539015787 ligand binding site [chemical binding]; other site 1064539015788 hypothetical protein; Validated; Region: PRK09039 1064539015789 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064539015790 ligand binding site [chemical binding]; other site 1064539015791 Evidence 2b : Function of strongly homologous gene; PubMedId : 8165245; Product type e : enzyme 1064539015792 Evidence 2b : Function of strongly homologous gene; PubMedId : 8165245; Product type e : enzyme 1064539015793 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1064539015794 lipoyl attachment site [posttranslational modification]; other site 1064539015795 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1064539015796 Amidinotransferase; Region: Amidinotransf; cl12043 1064539015797 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1064539015798 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 1064539015799 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1064539015800 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1064539015801 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1064539015802 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1064539015803 putative active site [active] 1064539015804 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1064539015805 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1064539015806 putative active site [active] 1064539015807 putative substrate binding site [chemical binding]; other site 1064539015808 ATP binding site [chemical binding]; other site 1064539015809 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1064539015810 RNA/DNA hybrid binding site [nucleotide binding]; other site 1064539015811 active site 1064539015812 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1064539015813 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1064539015814 acyl-activating enzyme (AAE) consensus motif; other site 1064539015815 putative AMP binding site [chemical binding]; other site 1064539015816 putative active site [active] 1064539015817 putative CoA binding site [chemical binding]; other site 1064539015818 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1064539015819 catalytic triad [active] 1064539015820 dimer interface [polypeptide binding]; other site 1064539015821 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1064539015822 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1064539015823 DsbD alpha interface [polypeptide binding]; other site 1064539015824 catalytic residues [active] 1064539015825 hypothetical protein; Validated; Region: PRK00228 1064539015826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1064539015827 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1064539015828 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1064539015829 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1064539015830 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1064539015831 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1064539015832 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1064539015833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539015834 catalytic residue [active] 1064539015835 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1064539015836 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1064539015837 Evidence 2b : Function of strongly homologous gene; PubMedId : 7765282; Product type e : enzyme 1064539015838 Evidence 2b : Function of strongly homologous gene; PubMedId : 7765282; Product type e : enzyme 1064539015839 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1064539015840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 1064539015841 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1064539015842 Subunit III/VIIa interface [polypeptide binding]; other site 1064539015843 Phospholipid binding site [chemical binding]; other site 1064539015844 Subunit I/III interface [polypeptide binding]; other site 1064539015845 Subunit III/VIb interface [polypeptide binding]; other site 1064539015846 Subunit III/VIa interface; other site 1064539015847 Subunit III/Vb interface [polypeptide binding]; other site 1064539015848 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442 1064539015849 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1064539015850 UbiA prenyltransferase family; Region: UbiA; pfam01040 1064539015851 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1064539015852 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1064539015853 Subunit I/III interface [polypeptide binding]; other site 1064539015854 D-pathway; other site 1064539015855 Subunit I/VIIc interface [polypeptide binding]; other site 1064539015856 Subunit I/IV interface [polypeptide binding]; other site 1064539015857 Subunit I/II interface [polypeptide binding]; other site 1064539015858 Low-spin heme (heme a) binding site [chemical binding]; other site 1064539015859 Subunit I/VIIa interface [polypeptide binding]; other site 1064539015860 Subunit I/VIa interface [polypeptide binding]; other site 1064539015861 Dimer interface; other site 1064539015862 Putative water exit pathway; other site 1064539015863 Binuclear center (heme a3/CuB) [ion binding]; other site 1064539015864 K-pathway; other site 1064539015865 Subunit I/Vb interface [polypeptide binding]; other site 1064539015866 Putative proton exit pathway; other site 1064539015867 Subunit I/VIb interface; other site 1064539015868 Subunit I/VIc interface [polypeptide binding]; other site 1064539015869 Electron transfer pathway; other site 1064539015870 Subunit I/VIIIb interface [polypeptide binding]; other site 1064539015871 Subunit I/VIIb interface [polypeptide binding]; other site 1064539015872 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1064539015873 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 1064539015874 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1064539015875 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 1064539015876 protease TldD; Provisional; Region: tldD; PRK10735 1064539015877 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1064539015878 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1064539015879 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1064539015880 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1064539015881 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539015882 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539015883 DNA binding residues [nucleotide binding] 1064539015884 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064539015885 Sel1-like repeats; Region: SEL1; smart00671 1064539015886 Sel1-like repeats; Region: SEL1; smart00671 1064539015887 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1064539015888 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539015889 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539015890 catalytic residue [active] 1064539015891 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1064539015892 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9464392; Product type e : enzyme 1064539015893 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9464392; Product type e : enzyme 1064539015894 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1064539015895 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064539015896 RNA binding surface [nucleotide binding]; other site 1064539015897 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1064539015898 active site 1064539015899 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1064539015900 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1064539015901 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539015902 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539015903 DNA binding residues [nucleotide binding] 1064539015904 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1064539015905 active site 1064539015906 ATP binding site [chemical binding]; other site 1064539015907 substrate binding site [chemical binding]; other site 1064539015908 activation loop (A-loop); other site 1064539015909 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1064539015910 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1064539015911 GDP-binding site [chemical binding]; other site 1064539015912 ACT binding site; other site 1064539015913 IMP binding site; other site 1064539015914 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 1064539015915 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1064539015916 dimer interface [polypeptide binding]; other site 1064539015917 motif 1; other site 1064539015918 active site 1064539015919 motif 2; other site 1064539015920 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1064539015921 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1064539015922 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 1064539015923 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539015924 catalytic residue [active] 1064539015925 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1064539015926 Asp-box motif; other site 1064539015927 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 1064539015928 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539015929 FeS/SAM binding site; other site 1064539015930 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1064539015931 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1064539015932 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 1064539015933 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1064539015934 NAD binding site [chemical binding]; other site 1064539015935 homotetramer interface [polypeptide binding]; other site 1064539015936 homodimer interface [polypeptide binding]; other site 1064539015937 substrate binding site [chemical binding]; other site 1064539015938 active site 1064539015939 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1064539015940 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1064539015941 Tetramer interface [polypeptide binding]; other site 1064539015942 active site 1064539015943 FMN-binding site [chemical binding]; other site 1064539015944 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539015945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539015946 active site 1064539015947 phosphorylation site [posttranslational modification] 1064539015948 intermolecular recognition site; other site 1064539015949 dimerization interface [polypeptide binding]; other site 1064539015950 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1064539015951 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1064539015952 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1064539015953 tandem repeat interface [polypeptide binding]; other site 1064539015954 oligomer interface [polypeptide binding]; other site 1064539015955 active site residues [active] 1064539015956 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1064539015957 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1064539015958 tandem repeat interface [polypeptide binding]; other site 1064539015959 oligomer interface [polypeptide binding]; other site 1064539015960 active site residues [active] 1064539015961 CheB methylesterase; Region: CheB_methylest; pfam01339 1064539015962 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1064539015963 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1064539015964 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1064539015965 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 1064539015966 PAS domain; Region: PAS_10; pfam13596 1064539015967 PAS domain S-box; Region: sensory_box; TIGR00229 1064539015968 PAS fold; Region: PAS; pfam00989 1064539015969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539015970 putative active site [active] 1064539015971 heme pocket [chemical binding]; other site 1064539015972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539015973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539015974 dimer interface [polypeptide binding]; other site 1064539015975 phosphorylation site [posttranslational modification] 1064539015976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539015977 ATP binding site [chemical binding]; other site 1064539015978 Mg2+ binding site [ion binding]; other site 1064539015979 G-X-G motif; other site 1064539015980 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539015981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539015982 active site 1064539015983 phosphorylation site [posttranslational modification] 1064539015984 intermolecular recognition site; other site 1064539015985 dimerization interface [polypeptide binding]; other site 1064539015986 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1064539015987 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1064539015988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1064539015989 Walker A/P-loop; other site 1064539015990 ATP binding site [chemical binding]; other site 1064539015991 Q-loop/lid; other site 1064539015992 ABC transporter signature motif; other site 1064539015993 Walker B; other site 1064539015994 D-loop; other site 1064539015995 H-loop/switch region; other site 1064539015996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539015997 putative substrate translocation pore; other site 1064539015998 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1064539015999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539016000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539016001 dimerization interface [polypeptide binding]; other site 1064539016002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539016003 dimer interface [polypeptide binding]; other site 1064539016004 phosphorylation site [posttranslational modification] 1064539016005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539016006 ATP binding site [chemical binding]; other site 1064539016007 Mg2+ binding site [ion binding]; other site 1064539016008 G-X-G motif; other site 1064539016009 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1064539016010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539016011 active site 1064539016012 phosphorylation site [posttranslational modification] 1064539016013 intermolecular recognition site; other site 1064539016014 dimerization interface [polypeptide binding]; other site 1064539016015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539016016 DNA binding site [nucleotide binding] 1064539016017 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539016018 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539016019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539016020 TPR repeat; Region: TPR_11; pfam13414 1064539016021 binding surface 1064539016022 TPR motif; other site 1064539016023 elongation factor G; Reviewed; Region: PRK00007 1064539016024 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1064539016025 G1 box; other site 1064539016026 putative GEF interaction site [polypeptide binding]; other site 1064539016027 GTP/Mg2+ binding site [chemical binding]; other site 1064539016028 Switch I region; other site 1064539016029 G2 box; other site 1064539016030 G3 box; other site 1064539016031 Switch II region; other site 1064539016032 G4 box; other site 1064539016033 G5 box; other site 1064539016034 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1064539016035 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1064539016036 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1064539016037 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1064539016038 homotrimer interaction site [polypeptide binding]; other site 1064539016039 putative active site [active] 1064539016040 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1064539016041 active site 1064539016042 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1064539016043 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 1064539016044 active site 1064539016045 putative interdomain interaction site [polypeptide binding]; other site 1064539016046 putative metal-binding site [ion binding]; other site 1064539016047 putative nucleotide binding site [chemical binding]; other site 1064539016048 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1064539016049 domain I; other site 1064539016050 DNA binding groove [nucleotide binding] 1064539016051 phosphate binding site [ion binding]; other site 1064539016052 domain II; other site 1064539016053 domain III; other site 1064539016054 nucleotide binding site [chemical binding]; other site 1064539016055 catalytic site [active] 1064539016056 domain IV; other site 1064539016057 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1064539016058 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1064539016059 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539016060 active site 1064539016061 potential frameshift: common BLAST hit: gi|163852137|ref|YP_001640180.1| HhH-GPD family protein 1064539016062 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1064539016063 helix-hairpin-helix signature motif; other site 1064539016064 substrate binding pocket [chemical binding]; other site 1064539016065 active site 1064539016066 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1064539016067 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1064539016068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1064539016069 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1064539016070 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1064539016071 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1064539016072 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1064539016073 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539016074 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1064539016075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539016076 DNA binding residues [nucleotide binding] 1064539016077 DNA primase, catalytic core; Region: dnaG; TIGR01391 1064539016078 CHC2 zinc finger; Region: zf-CHC2; cl17510 1064539016079 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1064539016080 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1064539016081 active site 1064539016082 metal binding site [ion binding]; metal-binding site 1064539016083 interdomain interaction site; other site 1064539016084 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1064539016085 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1064539016086 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1064539016087 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1064539016088 catalytic site [active] 1064539016089 subunit interface [polypeptide binding]; other site 1064539016090 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539016091 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539016092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539016093 dimer interface [polypeptide binding]; other site 1064539016094 phosphorylation site [posttranslational modification] 1064539016095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539016096 ATP binding site [chemical binding]; other site 1064539016097 Mg2+ binding site [ion binding]; other site 1064539016098 G-X-G motif; other site 1064539016099 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539016100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539016101 active site 1064539016102 phosphorylation site [posttranslational modification] 1064539016103 intermolecular recognition site; other site 1064539016104 dimerization interface [polypeptide binding]; other site 1064539016105 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1064539016106 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1064539016107 ligand binding site [chemical binding]; other site 1064539016108 NAD binding site [chemical binding]; other site 1064539016109 tetramer interface [polypeptide binding]; other site 1064539016110 catalytic site [active] 1064539016111 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1064539016112 L-serine binding site [chemical binding]; other site 1064539016113 ACT domain interface; other site 1064539016114 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1064539016115 ArsC family; Region: ArsC; pfam03960 1064539016116 catalytic residues [active] 1064539016117 HemK family putative methylases; Region: hemK_fam; TIGR00536 1064539016118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539016119 S-adenosylmethionine binding site [chemical binding]; other site 1064539016120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539016121 Coenzyme A binding pocket [chemical binding]; other site 1064539016122 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1064539016123 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1064539016124 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1064539016125 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064539016126 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1064539016127 isocitrate dehydrogenase; Validated; Region: PRK08299 1064539016128 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1064539016129 NAD(P) binding site [chemical binding]; other site 1064539016130 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1064539016131 GcrA cell cycle regulator; Region: GcrA; cl11564 1064539016132 Putative zinc-finger; Region: zf-HC2; pfam13490 1064539016133 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1064539016134 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1064539016135 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539016136 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539016137 DNA binding residues [nucleotide binding] 1064539016138 isocitrate dehydrogenase; Validated; Region: PRK09222 1064539016139 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1064539016140 Phosphate-starvation-inducible E; Region: PsiE; cl01264 1064539016141 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1064539016142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539016143 dimerization interface [polypeptide binding]; other site 1064539016144 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539016145 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539016146 dimer interface [polypeptide binding]; other site 1064539016147 putative CheW interface [polypeptide binding]; other site 1064539016148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1064539016149 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1064539016150 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064539016151 Zn2+ binding site [ion binding]; other site 1064539016152 Mg2+ binding site [ion binding]; other site 1064539016153 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1064539016154 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1064539016155 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1064539016156 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1064539016157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539016158 catalytic residue [active] 1064539016159 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1064539016160 TIGR02594 family protein; Region: TIGR02594 1064539016161 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1064539016162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539016163 Walker A motif; other site 1064539016164 ATP binding site [chemical binding]; other site 1064539016165 Walker B motif; other site 1064539016166 arginine finger; other site 1064539016167 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1064539016168 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1064539016169 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1064539016170 motif 1; other site 1064539016171 active site 1064539016172 motif 2; other site 1064539016173 motif 3; other site 1064539016174 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1064539016175 recombinase A; Provisional; Region: recA; PRK09354 1064539016176 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1064539016177 hexamer interface [polypeptide binding]; other site 1064539016178 Walker A motif; other site 1064539016179 ATP binding site [chemical binding]; other site 1064539016180 Walker B motif; other site 1064539016181 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 1064539016182 PAS domain; Region: PAS; smart00091 1064539016183 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539016184 PAS domain; Region: PAS; smart00091 1064539016185 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539016186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539016187 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1064539016188 putative active site [active] 1064539016189 heme pocket [chemical binding]; other site 1064539016190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539016191 dimer interface [polypeptide binding]; other site 1064539016192 phosphorylation site [posttranslational modification] 1064539016193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539016194 ATP binding site [chemical binding]; other site 1064539016195 Mg2+ binding site [ion binding]; other site 1064539016196 G-X-G motif; other site 1064539016197 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539016198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539016199 active site 1064539016200 phosphorylation site [posttranslational modification] 1064539016201 intermolecular recognition site; other site 1064539016202 dimerization interface [polypeptide binding]; other site 1064539016203 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1064539016204 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1064539016205 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1064539016206 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1064539016207 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 1064539016208 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9161424; Product type s : structure 1064539016209 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9161424; Product type s : structure 1064539016210 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 1064539016211 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1064539016212 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1064539016213 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1064539016214 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1064539016215 potassium uptake protein; Region: kup; TIGR00794 1064539016216 flagellar motor protein MotS; Reviewed; Region: PRK06925 1064539016217 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1064539016218 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1064539016219 General stress protein [General function prediction only]; Region: GsiB; COG3729 1064539016220 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1064539016221 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 1064539016222 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1064539016223 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1064539016224 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 1064539016225 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1064539016226 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1064539016227 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 1064539016228 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064539016229 SAF-like; Region: SAF_2; pfam13144 1064539016230 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1064539016231 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1064539016232 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1064539016233 MAEBL; Provisional; Region: PTZ00121 1064539016234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539016235 TPR motif; other site 1064539016236 binding surface 1064539016237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539016238 TPR motif; other site 1064539016239 TPR repeat; Region: TPR_11; pfam13414 1064539016240 binding surface 1064539016241 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1064539016242 Alpha 1,4-glycosyltransferase conserved region; Region: Gb3_synth; pfam04572 1064539016243 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1064539016244 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1064539016245 flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787 1064539016246 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1064539016247 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1064539016248 Rod binding protein; Region: Rod-binding; cl01626 1064539016249 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1064539016250 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1064539016251 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 1064539016252 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1064539016253 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 1064539016254 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1064539016255 putative active site [active] 1064539016256 putative catalytic site [active] 1064539016257 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1064539016258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539016259 S-adenosylmethionine binding site [chemical binding]; other site 1064539016260 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 1064539016261 Evidence 2b : Function of strongly homologous gene; Product type t : transporter 1064539016262 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 1064539016263 Evidence 2b : Function of strongly homologous gene; Product type t : transporter 1064539016264 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539016265 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 1064539016266 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 1064539016267 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1064539016268 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1064539016269 putative dimer interface [polypeptide binding]; other site 1064539016270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539016271 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539016272 putative active site [active] 1064539016273 heme pocket [chemical binding]; other site 1064539016274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539016275 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1064539016276 putative active site [active] 1064539016277 heme pocket [chemical binding]; other site 1064539016278 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1064539016279 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539016280 dimer interface [polypeptide binding]; other site 1064539016281 phosphorylation site [posttranslational modification] 1064539016282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539016283 ATP binding site [chemical binding]; other site 1064539016284 Mg2+ binding site [ion binding]; other site 1064539016285 G-X-G motif; other site 1064539016286 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1064539016287 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1064539016288 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 1064539016289 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1064539016290 homodimer interface [polypeptide binding]; other site 1064539016291 substrate-cofactor binding pocket; other site 1064539016292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539016293 catalytic residue [active] 1064539016294 carboxylate-amine ligase; Provisional; Region: PRK13515 1064539016295 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1064539016296 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1064539016297 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539016298 EamA-like transporter family; Region: EamA; pfam00892 1064539016299 EamA-like transporter family; Region: EamA; pfam00892 1064539016300 transcriptional regulator NanR; Provisional; Region: PRK03837 1064539016301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539016302 DNA-binding site [nucleotide binding]; DNA binding site 1064539016303 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1064539016304 adenylate kinase; Reviewed; Region: adk; PRK00279 1064539016305 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1064539016306 AMP-binding site [chemical binding]; other site 1064539016307 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1064539016308 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1064539016309 SecY translocase; Region: SecY; pfam00344 1064539016310 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1064539016311 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1064539016312 23S rRNA binding site [nucleotide binding]; other site 1064539016313 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1064539016314 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1064539016315 5S rRNA interface [nucleotide binding]; other site 1064539016316 23S rRNA interface [nucleotide binding]; other site 1064539016317 L5 interface [polypeptide binding]; other site 1064539016318 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1064539016319 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1064539016320 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1064539016321 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type s : structure 1064539016322 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type s : structure 1064539016323 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1064539016324 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1064539016325 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1064539016326 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1064539016327 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1064539016328 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1064539016329 RNA binding site [nucleotide binding]; other site 1064539016330 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1064539016331 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1064539016332 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1064539016333 putative translocon interaction site; other site 1064539016334 23S rRNA interface [nucleotide binding]; other site 1064539016335 signal recognition particle (SRP54) interaction site; other site 1064539016336 L23 interface [polypeptide binding]; other site 1064539016337 trigger factor interaction site; other site 1064539016338 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1064539016339 23S rRNA interface [nucleotide binding]; other site 1064539016340 5S rRNA interface [nucleotide binding]; other site 1064539016341 putative antibiotic binding site [chemical binding]; other site 1064539016342 L25 interface [polypeptide binding]; other site 1064539016343 L27 interface [polypeptide binding]; other site 1064539016344 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1064539016345 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1064539016346 G-X-X-G motif; other site 1064539016347 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1064539016348 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1064539016349 putative translocon binding site; other site 1064539016350 protein-rRNA interface [nucleotide binding]; other site 1064539016351 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1064539016352 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1064539016353 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1064539016354 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1064539016355 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1064539016356 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1064539016357 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1064539016358 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1064539016359 elongation factor Tu; Reviewed; Region: PRK00049 1064539016360 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1064539016361 G1 box; other site 1064539016362 GEF interaction site [polypeptide binding]; other site 1064539016363 GTP/Mg2+ binding site [chemical binding]; other site 1064539016364 Switch I region; other site 1064539016365 G2 box; other site 1064539016366 G3 box; other site 1064539016367 Switch II region; other site 1064539016368 G4 box; other site 1064539016369 G5 box; other site 1064539016370 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1064539016371 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1064539016372 Antibiotic Binding Site [chemical binding]; other site 1064539016373 elongation factor G; Reviewed; Region: PRK00007 1064539016374 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1064539016375 G1 box; other site 1064539016376 putative GEF interaction site [polypeptide binding]; other site 1064539016377 GTP/Mg2+ binding site [chemical binding]; other site 1064539016378 Switch I region; other site 1064539016379 G2 box; other site 1064539016380 G3 box; other site 1064539016381 Switch II region; other site 1064539016382 G4 box; other site 1064539016383 G5 box; other site 1064539016384 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1064539016385 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1064539016386 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1064539016387 30S ribosomal protein S7; Validated; Region: PRK05302 1064539016388 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1064539016389 S17 interaction site [polypeptide binding]; other site 1064539016390 S8 interaction site; other site 1064539016391 16S rRNA interaction site [nucleotide binding]; other site 1064539016392 streptomycin interaction site [chemical binding]; other site 1064539016393 23S rRNA interaction site [nucleotide binding]; other site 1064539016394 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1064539016395 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1064539016396 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1064539016397 conserved cys residue [active] 1064539016398 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1064539016399 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1064539016400 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1064539016401 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1064539016402 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1064539016403 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1064539016404 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1064539016405 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1064539016406 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1064539016407 DNA binding site [nucleotide binding] 1064539016408 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1064539016409 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1064539016410 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1064539016411 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1064539016412 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1064539016413 RPB11 interaction site [polypeptide binding]; other site 1064539016414 RPB12 interaction site [polypeptide binding]; other site 1064539016415 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1064539016416 RPB1 interaction site [polypeptide binding]; other site 1064539016417 RPB11 interaction site [polypeptide binding]; other site 1064539016418 RPB3 interaction site [polypeptide binding]; other site 1064539016419 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1064539016420 L11 interface [polypeptide binding]; other site 1064539016421 putative EF-Tu interaction site [polypeptide binding]; other site 1064539016422 putative EF-G interaction site [polypeptide binding]; other site 1064539016423 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1064539016424 23S rRNA interface [nucleotide binding]; other site 1064539016425 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1064539016426 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1064539016427 mRNA/rRNA interface [nucleotide binding]; other site 1064539016428 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1064539016429 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1064539016430 23S rRNA interface [nucleotide binding]; other site 1064539016431 L7/L12 interface [polypeptide binding]; other site 1064539016432 putative thiostrepton binding site; other site 1064539016433 L25 interface [polypeptide binding]; other site 1064539016434 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1064539016435 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1064539016436 putative homodimer interface [polypeptide binding]; other site 1064539016437 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1064539016438 heterodimer interface [polypeptide binding]; other site 1064539016439 homodimer interface [polypeptide binding]; other site 1064539016440 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1064539016441 elongation factor Tu; Reviewed; Region: PRK00049 1064539016442 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1064539016443 G1 box; other site 1064539016444 GEF interaction site [polypeptide binding]; other site 1064539016445 GTP/Mg2+ binding site [chemical binding]; other site 1064539016446 Switch I region; other site 1064539016447 G2 box; other site 1064539016448 G3 box; other site 1064539016449 Switch II region; other site 1064539016450 G4 box; other site 1064539016451 G5 box; other site 1064539016452 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1064539016453 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1064539016454 Antibiotic Binding Site [chemical binding]; other site 1064539016455 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1064539016456 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1064539016457 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1064539016458 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1064539016459 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064539016460 active site 1064539016461 DNA binding site [nucleotide binding] 1064539016462 Int/Topo IB signature motif; other site 1064539016463 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1064539016464 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1064539016465 catalytic residues [active] 1064539016466 catalytic nucleophile [active] 1064539016467 Hemerythrin; Region: Hemerythrin; cd12107 1064539016468 Fe binding site [ion binding]; other site 1064539016469 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1064539016470 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1064539016471 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1064539016472 SLBB domain; Region: SLBB; pfam10531 1064539016473 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1064539016474 MarR family; Region: MarR_2; pfam12802 1064539016475 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064539016476 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539016477 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 1064539016478 putative ligand binding site [chemical binding]; other site 1064539016479 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539016480 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539016481 TM-ABC transporter signature motif; other site 1064539016482 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539016483 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539016484 TM-ABC transporter signature motif; other site 1064539016485 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539016486 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539016487 Walker A/P-loop; other site 1064539016488 ATP binding site [chemical binding]; other site 1064539016489 Q-loop/lid; other site 1064539016490 ABC transporter signature motif; other site 1064539016491 Walker B; other site 1064539016492 D-loop; other site 1064539016493 H-loop/switch region; other site 1064539016494 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539016495 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539016496 Walker A/P-loop; other site 1064539016497 ATP binding site [chemical binding]; other site 1064539016498 Q-loop/lid; other site 1064539016499 ABC transporter signature motif; other site 1064539016500 Walker B; other site 1064539016501 D-loop; other site 1064539016502 H-loop/switch region; other site 1064539016503 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1064539016504 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1064539016505 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1064539016506 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1064539016507 active site 1064539016508 dimer interface [polypeptide binding]; other site 1064539016509 fructokinase; Reviewed; Region: PRK09557 1064539016510 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064539016511 nucleotide binding site [chemical binding]; other site 1064539016512 AAA domain; Region: AAA_22; pfam13401 1064539016513 Tetratricopeptide repeat; Region: TPR_2; pfam07719 1064539016514 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1064539016515 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1064539016516 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1064539016517 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1064539016518 HAMP domain; Region: HAMP; pfam00672 1064539016519 dimerization interface [polypeptide binding]; other site 1064539016520 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539016521 dimer interface [polypeptide binding]; other site 1064539016522 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1064539016523 putative CheW interface [polypeptide binding]; other site 1064539016524 hypothetical protein; Validated; Region: PRK09104 1064539016525 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1064539016526 metal binding site [ion binding]; metal-binding site 1064539016527 putative dimer interface [polypeptide binding]; other site 1064539016528 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1064539016529 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539016530 Walker A/P-loop; other site 1064539016531 ATP binding site [chemical binding]; other site 1064539016532 Q-loop/lid; other site 1064539016533 ABC transporter signature motif; other site 1064539016534 Walker B; other site 1064539016535 D-loop; other site 1064539016536 H-loop/switch region; other site 1064539016537 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1064539016538 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539016539 Walker A/P-loop; other site 1064539016540 ATP binding site [chemical binding]; other site 1064539016541 Q-loop/lid; other site 1064539016542 ABC transporter signature motif; other site 1064539016543 Walker B; other site 1064539016544 D-loop; other site 1064539016545 H-loop/switch region; other site 1064539016546 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539016547 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539016548 TM-ABC transporter signature motif; other site 1064539016549 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539016550 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539016551 TM-ABC transporter signature motif; other site 1064539016552 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539016553 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1064539016554 putative ligand binding site [chemical binding]; other site 1064539016555 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1064539016556 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1064539016557 catalytic triad [active] 1064539016558 conserved cis-peptide bond; other site 1064539016559 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1064539016560 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1064539016561 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064539016562 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1064539016563 metal binding site [ion binding]; metal-binding site 1064539016564 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539016565 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539016566 Walker A/P-loop; other site 1064539016567 ATP binding site [chemical binding]; other site 1064539016568 Q-loop/lid; other site 1064539016569 ABC transporter signature motif; other site 1064539016570 Walker B; other site 1064539016571 D-loop; other site 1064539016572 H-loop/switch region; other site 1064539016573 NMT1/THI5 like; Region: NMT1; pfam09084 1064539016574 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539016575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539016576 dimer interface [polypeptide binding]; other site 1064539016577 conserved gate region; other site 1064539016578 ABC-ATPase subunit interface; other site 1064539016579 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1064539016580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539016581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1064539016582 MORN repeat; Region: MORN; cl14787 1064539016583 Caspase domain; Region: Peptidase_C14; pfam00656 1064539016584 Bacterial SH3 domain; Region: SH3_3; pfam08239 1064539016585 Caspase domain; Region: Peptidase_C14; pfam00656 1064539016586 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1064539016587 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1064539016588 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1064539016589 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 1064539016590 Cupin domain; Region: Cupin_2; cl17218 1064539016591 potential frameshift: common BLAST hit: gi|222523947|ref|YP_002568417.1| AMP-dependent synthetase and ligase 1064539016592 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539016593 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539016594 acyl-activating enzyme (AAE) consensus motif; other site 1064539016595 AMP binding site [chemical binding]; other site 1064539016596 active site 1064539016597 CoA binding site [chemical binding]; other site 1064539016598 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539016599 substrate binding site [chemical binding]; other site 1064539016600 oxyanion hole (OAH) forming residues; other site 1064539016601 trimer interface [polypeptide binding]; other site 1064539016602 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1064539016603 NAD(P) binding site [chemical binding]; other site 1064539016604 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1064539016605 NAD(P) binding site [chemical binding]; other site 1064539016606 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539016607 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539016608 Walker A/P-loop; other site 1064539016609 ATP binding site [chemical binding]; other site 1064539016610 Q-loop/lid; other site 1064539016611 ABC transporter signature motif; other site 1064539016612 Walker B; other site 1064539016613 D-loop; other site 1064539016614 H-loop/switch region; other site 1064539016615 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539016616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539016617 dimer interface [polypeptide binding]; other site 1064539016618 conserved gate region; other site 1064539016619 ABC-ATPase subunit interface; other site 1064539016620 NMT1/THI5 like; Region: NMT1; pfam09084 1064539016621 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539016622 substrate binding pocket [chemical binding]; other site 1064539016623 membrane-bound complex binding site; other site 1064539016624 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1064539016625 peptide chain release factor 2; Provisional; Region: PRK07342 1064539016626 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1064539016627 RF-1 domain; Region: RF-1; pfam00472 1064539016628 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1064539016629 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1064539016630 catalytic triad [active] 1064539016631 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1064539016632 Transglycosylase; Region: Transgly; pfam00912 1064539016633 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1064539016634 AMIN domain; Region: AMIN; pfam11741 1064539016635 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1064539016636 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1064539016637 active site 1064539016638 metal binding site [ion binding]; metal-binding site 1064539016639 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1064539016640 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1064539016641 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 1064539016642 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1064539016643 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1064539016644 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1064539016645 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1064539016646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539016647 motif II; other site 1064539016648 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1064539016649 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1064539016650 catalytic residues [active] 1064539016651 Peptidase family M48; Region: Peptidase_M48; cl12018 1064539016652 TPR repeat; Region: TPR_11; pfam13414 1064539016653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539016654 TPR motif; other site 1064539016655 binding surface 1064539016656 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 18720502, 1360205, 1358750; Product type pe : putative enzyme 1064539016657 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 18720502, 1360205, 1358750; Product type pe : putative enzyme 1064539016658 aspartate aminotransferase; Provisional; Region: PRK05764 1064539016659 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539016660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539016661 homodimer interface [polypeptide binding]; other site 1064539016662 catalytic residue [active] 1064539016663 glutamate--cysteine ligase; Region: PLN02611 1064539016664 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1064539016665 RNA methyltransferase, RsmE family; Region: TIGR00046 1064539016666 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 1064539016667 UbiA prenyltransferase family; Region: UbiA; pfam01040 1064539016668 Predicted methyltransferase [General function prediction only]; Region: COG3897 1064539016669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539016670 S-adenosylmethionine binding site [chemical binding]; other site 1064539016671 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1064539016672 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1064539016673 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 1064539016674 Predicted membrane protein [Function unknown]; Region: COG2259 1064539016675 peptidase PmbA; Provisional; Region: PRK11040 1064539016676 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1064539016677 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1064539016678 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1064539016679 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1064539016680 putative active site [active] 1064539016681 putative metal binding site [ion binding]; other site 1064539016682 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539016683 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1064539016684 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1064539016685 heme-binding site [chemical binding]; other site 1064539016686 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539016687 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539016688 dimer interface [polypeptide binding]; other site 1064539016689 putative CheW interface [polypeptide binding]; other site 1064539016690 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1064539016691 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1064539016692 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 1064539016693 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1064539016694 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1064539016695 putative acyl-acceptor binding pocket; other site 1064539016696 LysE type translocator; Region: LysE; cl00565 1064539016697 NADH dehydrogenase; Validated; Region: PRK08183 1064539016698 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1064539016699 mce related protein; Region: MCE; pfam02470 1064539016700 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 1064539016701 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1064539016702 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1064539016703 B1 nucleotide binding pocket [chemical binding]; other site 1064539016704 B2 nucleotide binding pocket [chemical binding]; other site 1064539016705 CAS motifs; other site 1064539016706 active site 1064539016707 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1064539016708 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1064539016709 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1064539016710 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1064539016711 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1064539016712 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1064539016713 carboxyltransferase (CT) interaction site; other site 1064539016714 biotinylation site [posttranslational modification]; other site 1064539016715 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1064539016716 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1064539016717 trimer interface [polypeptide binding]; other site 1064539016718 active site 1064539016719 dimer interface [polypeptide binding]; other site 1064539016720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539016721 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539016722 substrate binding pocket [chemical binding]; other site 1064539016723 membrane-bound complex binding site; other site 1064539016724 hinge residues; other site 1064539016725 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1064539016726 G1 box; other site 1064539016727 GTP/Mg2+ binding site [chemical binding]; other site 1064539016728 G2 box; other site 1064539016729 Switch I region; other site 1064539016730 G3 box; other site 1064539016731 Switch II region; other site 1064539016732 G4 box; other site 1064539016733 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539016734 dimerization interface [polypeptide binding]; other site 1064539016735 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539016736 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539016737 dimer interface [polypeptide binding]; other site 1064539016738 putative CheW interface [polypeptide binding]; other site 1064539016739 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539016740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539016741 salt bridge; other site 1064539016742 non-specific DNA binding site [nucleotide binding]; other site 1064539016743 sequence-specific DNA binding site [nucleotide binding]; other site 1064539016744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1064539016745 Peptidase M15; Region: Peptidase_M15_3; cl01194 1064539016746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1064539016747 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1064539016748 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064539016749 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064539016750 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1064539016751 30S subunit binding site; other site 1064539016752 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064539016753 DNA-binding site [nucleotide binding]; DNA binding site 1064539016754 RNA-binding motif; other site 1064539016755 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1064539016756 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1064539016757 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1064539016758 NodB motif; other site 1064539016759 active site 1064539016760 catalytic site [active] 1064539016761 metal binding site [ion binding]; metal-binding site 1064539016762 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1064539016763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539016764 putative active site [active] 1064539016765 heme pocket [chemical binding]; other site 1064539016766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539016767 dimer interface [polypeptide binding]; other site 1064539016768 phosphorylation site [posttranslational modification] 1064539016769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539016770 ATP binding site [chemical binding]; other site 1064539016771 Mg2+ binding site [ion binding]; other site 1064539016772 G-X-G motif; other site 1064539016773 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 1064539016774 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 1064539016775 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1064539016776 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539016777 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539016778 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1064539016779 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1064539016780 NAD binding site [chemical binding]; other site 1064539016781 catalytic Zn binding site [ion binding]; other site 1064539016782 structural Zn binding site [ion binding]; other site 1064539016783 Predicted integral membrane protein [Function unknown]; Region: COG5637 1064539016784 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1064539016785 putative hydrophobic ligand binding site [chemical binding]; other site 1064539016786 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 1064539016787 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1064539016788 PGAP1-like protein; Region: PGAP1; pfam07819 1064539016789 LrgA family; Region: LrgA; pfam03788 1064539016790 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1064539016791 2-isopropylmalate synthase; Validated; Region: PRK03739 1064539016792 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1064539016793 active site 1064539016794 catalytic residues [active] 1064539016795 metal binding site [ion binding]; metal-binding site 1064539016796 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1064539016797 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1064539016798 DALR anticodon binding domain; Region: DALR_1; pfam05746 1064539016799 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1064539016800 dimer interface [polypeptide binding]; other site 1064539016801 motif 1; other site 1064539016802 active site 1064539016803 motif 2; other site 1064539016804 motif 3; other site 1064539016805 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1064539016806 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1064539016807 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1064539016808 tandem repeat interface [polypeptide binding]; other site 1064539016809 oligomer interface [polypeptide binding]; other site 1064539016810 active site residues [active] 1064539016811 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1064539016812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1064539016813 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1064539016814 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1064539016815 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1064539016816 substrate binding pocket [chemical binding]; other site 1064539016817 chain length determination region; other site 1064539016818 substrate-Mg2+ binding site; other site 1064539016819 catalytic residues [active] 1064539016820 aspartate-rich region 1; other site 1064539016821 active site lid residues [active] 1064539016822 aspartate-rich region 2; other site 1064539016823 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1064539016824 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1064539016825 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539016826 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539016827 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1064539016828 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1064539016829 FAD binding domain; Region: FAD_binding_4; pfam01565 1064539016830 5-oxoprolinase; Region: PLN02666 1064539016831 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1064539016832 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1064539016833 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1064539016834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539016835 Coenzyme A binding pocket [chemical binding]; other site 1064539016836 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1064539016837 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1064539016838 putative metal binding site [ion binding]; other site 1064539016839 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1064539016840 HSP70 interaction site [polypeptide binding]; other site 1064539016841 ABC transporter ATPase component; Reviewed; Region: PRK11147 1064539016842 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064539016843 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064539016844 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539016845 EamA-like transporter family; Region: EamA; pfam00892 1064539016846 EamA-like transporter family; Region: EamA; pfam00892 1064539016847 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1064539016848 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1064539016849 amidase catalytic site [active] 1064539016850 Zn binding residues [ion binding]; other site 1064539016851 substrate binding site [chemical binding]; other site 1064539016852 cell division protein MraZ; Reviewed; Region: PRK00326 1064539016853 MraZ protein; Region: MraZ; pfam02381 1064539016854 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1064539016855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539016856 S-adenosylmethionine binding site [chemical binding]; other site 1064539016857 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 1064539016858 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1064539016859 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1064539016860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1064539016861 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1064539016862 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1064539016863 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1064539016864 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1064539016865 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 1064539016866 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1064539016867 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1064539016868 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1064539016869 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1064539016870 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1064539016871 Mg++ binding site [ion binding]; other site 1064539016872 putative catalytic motif [active] 1064539016873 putative substrate binding site [chemical binding]; other site 1064539016874 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 1064539016875 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1064539016876 NAD(P) binding pocket [chemical binding]; other site 1064539016877 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1064539016878 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1064539016879 cell division protein FtsW; Region: ftsW; TIGR02614 1064539016880 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8449890; Product type e : enzyme 1064539016881 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1064539016882 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8449890; Product type e : enzyme 1064539016883 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1064539016884 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1064539016885 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1064539016886 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1064539016887 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1064539016888 FAD binding domain; Region: FAD_binding_4; pfam01565 1064539016889 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1064539016890 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1064539016891 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1064539016892 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1064539016893 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1064539016894 Cell division protein FtsQ; Region: FtsQ; pfam03799 1064539016895 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1064539016896 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064539016897 nucleotide binding site [chemical binding]; other site 1064539016898 Cell division protein FtsA; Region: FtsA; pfam14450 1064539016899 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1064539016900 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1064539016901 nucleotide binding site [chemical binding]; other site 1064539016902 SulA interaction site; other site 1064539016903 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1064539016904 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1064539016905 Hemerythrin; Region: Hemerythrin; cd12107 1064539016906 Fe binding site [ion binding]; other site 1064539016907 Ligase N family; Region: LIGANc; smart00532 1064539016908 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1064539016909 nucleotide binding pocket [chemical binding]; other site 1064539016910 K-X-D-G motif; other site 1064539016911 catalytic site [active] 1064539016912 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1064539016913 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1064539016914 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1064539016915 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1064539016916 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1064539016917 Dimer interface [polypeptide binding]; other site 1064539016918 BRCT sequence motif; other site 1064539016919 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1064539016920 heme-binding site [chemical binding]; other site 1064539016921 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1064539016922 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539016923 dimer interface [polypeptide binding]; other site 1064539016924 putative CheW interface [polypeptide binding]; other site 1064539016925 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1064539016926 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1064539016927 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1064539016928 Walker A/P-loop; other site 1064539016929 ATP binding site [chemical binding]; other site 1064539016930 Q-loop/lid; other site 1064539016931 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1064539016932 ABC transporter signature motif; other site 1064539016933 Walker B; other site 1064539016934 D-loop; other site 1064539016935 H-loop/switch region; other site 1064539016936 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1064539016937 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1064539016938 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1064539016939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539016940 active site 1064539016941 phosphorylation site [posttranslational modification] 1064539016942 intermolecular recognition site; other site 1064539016943 dimerization interface [polypeptide binding]; other site 1064539016944 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1064539016945 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1064539016946 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1064539016947 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1064539016948 active site 1064539016949 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 1064539016950 putative metal binding site [ion binding]; other site 1064539016951 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1064539016952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539016953 S-adenosylmethionine binding site [chemical binding]; other site 1064539016954 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064539016955 protein binding site [polypeptide binding]; other site 1064539016956 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1064539016957 Part of AAA domain; Region: AAA_19; pfam13245 1064539016958 Family description; Region: UvrD_C_2; pfam13538 1064539016959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539016960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539016961 active site 1064539016962 phosphorylation site [posttranslational modification] 1064539016963 intermolecular recognition site; other site 1064539016964 dimerization interface [polypeptide binding]; other site 1064539016965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539016966 DNA binding residues [nucleotide binding] 1064539016967 dimerization interface [polypeptide binding]; other site 1064539016968 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539016969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539016970 active site 1064539016971 phosphorylation site [posttranslational modification] 1064539016972 intermolecular recognition site; other site 1064539016973 dimerization interface [polypeptide binding]; other site 1064539016974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539016975 DNA binding residues [nucleotide binding] 1064539016976 dimerization interface [polypeptide binding]; other site 1064539016977 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1064539016978 hypothetical protein; Provisional; Region: PRK11770 1064539016979 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1064539016980 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 1064539016981 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 1064539016982 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1064539016983 Acetokinase family; Region: Acetate_kinase; cl17229 1064539016984 propionate/acetate kinase; Provisional; Region: PRK12379 1064539016985 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 1064539016986 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1064539016987 dimer interaction site [polypeptide binding]; other site 1064539016988 substrate-binding tunnel; other site 1064539016989 active site 1064539016990 catalytic site [active] 1064539016991 substrate binding site [chemical binding]; other site 1064539016992 phosphate acetyltransferase; Provisional; Region: PRK11890 1064539016993 CHASE domain; Region: CHASE; pfam03924 1064539016994 PAS fold; Region: PAS_4; pfam08448 1064539016995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539016996 putative active site [active] 1064539016997 heme pocket [chemical binding]; other site 1064539016998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539016999 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539017000 dimer interface [polypeptide binding]; other site 1064539017001 phosphorylation site [posttranslational modification] 1064539017002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539017003 ATP binding site [chemical binding]; other site 1064539017004 Mg2+ binding site [ion binding]; other site 1064539017005 G-X-G motif; other site 1064539017006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539017007 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539017008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017009 active site 1064539017010 phosphorylation site [posttranslational modification] 1064539017011 intermolecular recognition site; other site 1064539017012 dimerization interface [polypeptide binding]; other site 1064539017013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539017014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539017015 dimer interface [polypeptide binding]; other site 1064539017016 phosphorylation site [posttranslational modification] 1064539017017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539017018 ATP binding site [chemical binding]; other site 1064539017019 Mg2+ binding site [ion binding]; other site 1064539017020 G-X-G motif; other site 1064539017021 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 1064539017022 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539017023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017024 active site 1064539017025 phosphorylation site [posttranslational modification] 1064539017026 intermolecular recognition site; other site 1064539017027 dimerization interface [polypeptide binding]; other site 1064539017028 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1064539017029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1064539017030 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier 1064539017031 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier 1064539017032 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1064539017033 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539017034 FeS/SAM binding site; other site 1064539017035 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1064539017036 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 1064539017037 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1064539017038 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 1064539017039 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1064539017040 active site 1064539017041 Zn binding site [ion binding]; other site 1064539017042 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1064539017043 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1064539017044 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1064539017045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 1064539017046 CreA protein; Region: CreA; pfam05981 1064539017047 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1064539017048 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1064539017049 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1064539017050 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1064539017051 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1064539017052 HRDC domain; Region: HRDC; pfam00570 1064539017053 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1064539017054 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1064539017055 anti sigma factor interaction site; other site 1064539017056 regulatory phosphorylation site [posttranslational modification]; other site 1064539017057 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539017058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017059 active site 1064539017060 phosphorylation site [posttranslational modification] 1064539017061 intermolecular recognition site; other site 1064539017062 dimerization interface [polypeptide binding]; other site 1064539017063 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1064539017064 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1064539017065 diiron binding motif [ion binding]; other site 1064539017066 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1064539017067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539017068 dimer interface [polypeptide binding]; other site 1064539017069 conserved gate region; other site 1064539017070 putative PBP binding loops; other site 1064539017071 ABC-ATPase subunit interface; other site 1064539017072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539017073 dimer interface [polypeptide binding]; other site 1064539017074 conserved gate region; other site 1064539017075 putative PBP binding loops; other site 1064539017076 ABC-ATPase subunit interface; other site 1064539017077 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539017078 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539017079 Walker A/P-loop; other site 1064539017080 ATP binding site [chemical binding]; other site 1064539017081 Q-loop/lid; other site 1064539017082 ABC transporter signature motif; other site 1064539017083 Walker B; other site 1064539017084 D-loop; other site 1064539017085 H-loop/switch region; other site 1064539017086 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1064539017087 potential frameshift: common BLAST hit: gi|374290821|ref|YP_005037856.1| ATP-dependent helicase 1064539017088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064539017089 ATP binding site [chemical binding]; other site 1064539017090 putative Mg++ binding site [ion binding]; other site 1064539017091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539017092 nucleotide binding region [chemical binding]; other site 1064539017093 ATP-binding site [chemical binding]; other site 1064539017094 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1064539017095 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1064539017096 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1064539017097 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1064539017098 cyclase homology domain; Region: CHD; cd07302 1064539017099 nucleotidyl binding site; other site 1064539017100 metal binding site [ion binding]; metal-binding site 1064539017101 dimer interface [polypeptide binding]; other site 1064539017102 SpoVR family protein; Provisional; Region: PRK11767 1064539017103 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1064539017104 hypothetical protein; Provisional; Region: PRK05325 1064539017105 PrkA family serine protein kinase; Provisional; Region: PRK15455 1064539017106 AAA ATPase domain; Region: AAA_16; pfam13191 1064539017107 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1064539017108 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539017109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017110 active site 1064539017111 phosphorylation site [posttranslational modification] 1064539017112 intermolecular recognition site; other site 1064539017113 dimerization interface [polypeptide binding]; other site 1064539017114 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1064539017115 nudix motif; other site 1064539017116 PAS fold; Region: PAS_4; pfam08448 1064539017117 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539017118 putative active site [active] 1064539017119 heme pocket [chemical binding]; other site 1064539017120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539017121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1064539017122 dimer interface [polypeptide binding]; other site 1064539017123 phosphorylation site [posttranslational modification] 1064539017124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539017125 ATP binding site [chemical binding]; other site 1064539017126 Mg2+ binding site [ion binding]; other site 1064539017127 G-X-G motif; other site 1064539017128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017129 active site 1064539017130 phosphorylation site [posttranslational modification] 1064539017131 intermolecular recognition site; other site 1064539017132 dimerization interface [polypeptide binding]; other site 1064539017133 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1064539017134 active site 1064539017135 HIGH motif; other site 1064539017136 nucleotide binding site [chemical binding]; other site 1064539017137 active site 1064539017138 KMSKS motif; other site 1064539017139 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1064539017140 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1064539017141 active site 1064539017142 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1064539017143 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1064539017144 diiron binding motif [ion binding]; other site 1064539017145 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1064539017146 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1064539017147 Cytochrome c; Region: Cytochrom_C; cl11414 1064539017148 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1064539017149 active site residue [active] 1064539017150 NMT1/THI5 like; Region: NMT1; pfam09084 1064539017151 substrate binding pocket [chemical binding]; other site 1064539017152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1064539017153 membrane-bound complex binding site; other site 1064539017154 hinge residues; other site 1064539017155 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064539017156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539017157 dimer interface [polypeptide binding]; other site 1064539017158 conserved gate region; other site 1064539017159 putative PBP binding loops; other site 1064539017160 ABC-ATPase subunit interface; other site 1064539017161 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539017162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539017163 Walker A/P-loop; other site 1064539017164 ATP binding site [chemical binding]; other site 1064539017165 Q-loop/lid; other site 1064539017166 ABC transporter signature motif; other site 1064539017167 Walker B; other site 1064539017168 D-loop; other site 1064539017169 H-loop/switch region; other site 1064539017170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539017171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017172 active site 1064539017173 phosphorylation site [posttranslational modification] 1064539017174 intermolecular recognition site; other site 1064539017175 dimerization interface [polypeptide binding]; other site 1064539017176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539017177 DNA binding residues [nucleotide binding] 1064539017178 dimerization interface [polypeptide binding]; other site 1064539017179 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1064539017180 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1064539017181 dimer interface [polypeptide binding]; other site 1064539017182 Trp docking motif [polypeptide binding]; other site 1064539017183 active site 1064539017184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064539017185 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1064539017186 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1064539017187 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411266; Product type pt : putative transporter 1064539017188 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411266; Product type pt : putative transporter 1064539017189 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539017190 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539017191 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1064539017192 ligand binding site [chemical binding]; other site 1064539017193 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1064539017194 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1064539017195 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1064539017196 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1064539017197 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1064539017198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539017199 Walker A/P-loop; other site 1064539017200 ATP binding site [chemical binding]; other site 1064539017201 Q-loop/lid; other site 1064539017202 ABC transporter signature motif; other site 1064539017203 Walker B; other site 1064539017204 D-loop; other site 1064539017205 H-loop/switch region; other site 1064539017206 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1064539017207 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064539017208 PAS fold; Region: PAS_7; pfam12860 1064539017209 PAS fold; Region: PAS_4; pfam08448 1064539017210 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539017211 putative active site [active] 1064539017212 heme pocket [chemical binding]; other site 1064539017213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539017214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539017215 dimer interface [polypeptide binding]; other site 1064539017216 phosphorylation site [posttranslational modification] 1064539017217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539017218 ATP binding site [chemical binding]; other site 1064539017219 Mg2+ binding site [ion binding]; other site 1064539017220 G-X-G motif; other site 1064539017221 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539017222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017223 active site 1064539017224 phosphorylation site [posttranslational modification] 1064539017225 intermolecular recognition site; other site 1064539017226 dimerization interface [polypeptide binding]; other site 1064539017227 PAS fold; Region: PAS_7; pfam12860 1064539017228 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1064539017229 FIST N domain; Region: FIST; pfam08495 1064539017230 FIST C domain; Region: FIST_C; pfam10442 1064539017231 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1064539017232 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539017233 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539017234 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1064539017235 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1064539017236 Predicted membrane protein [Function unknown]; Region: COG1238 1064539017237 short chain dehydrogenase; Provisional; Region: PRK06181 1064539017238 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1064539017239 putative NAD(P) binding site [chemical binding]; other site 1064539017240 active site 1064539017241 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1064539017242 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1064539017243 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1064539017244 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1064539017245 PAS fold; Region: PAS_4; pfam08448 1064539017246 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10027974, 10922461, 11703663; Product type cp : cell process 1064539017247 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10027974, 10922461, 11703663; Product type cp : cell process 1064539017248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1064539017249 DinB superfamily; Region: DinB_2; pfam12867 1064539017250 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1064539017251 MgtC family; Region: MgtC; pfam02308 1064539017252 PAS fold; Region: PAS_4; pfam08448 1064539017253 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1064539017254 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1064539017255 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1064539017256 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1064539017257 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1064539017258 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1064539017259 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1064539017260 IMP binding site; other site 1064539017261 dimer interface [polypeptide binding]; other site 1064539017262 partial ornithine binding site; other site 1064539017263 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1064539017264 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1064539017265 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1064539017266 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1064539017267 Beta-lactamase; Region: Beta-lactamase; pfam00144 1064539017268 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1064539017269 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1064539017270 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1064539017271 AsnC family; Region: AsnC_trans_reg; pfam01037 1064539017272 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 1064539017273 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 1064539017274 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1064539017275 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1064539017276 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1064539017277 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064539017278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064539017279 Predicted membrane protein [Function unknown]; Region: COG2259 1064539017280 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1064539017281 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1064539017282 dimerization interface [polypeptide binding]; other site 1064539017283 DPS ferroxidase diiron center [ion binding]; other site 1064539017284 ion pore; other site 1064539017285 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1064539017286 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1064539017287 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1064539017288 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1064539017289 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1064539017290 elongation factor G; Reviewed; Region: PRK12740 1064539017291 G1 box; other site 1064539017292 putative GEF interaction site [polypeptide binding]; other site 1064539017293 GTP/Mg2+ binding site [chemical binding]; other site 1064539017294 Switch I region; other site 1064539017295 G2 box; other site 1064539017296 G3 box; other site 1064539017297 Switch II region; other site 1064539017298 G4 box; other site 1064539017299 G5 box; other site 1064539017300 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1064539017301 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1064539017302 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1064539017303 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1064539017304 aspartate aminotransferase; Provisional; Region: PRK05764 1064539017305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539017306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539017307 homodimer interface [polypeptide binding]; other site 1064539017308 catalytic residue [active] 1064539017309 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1064539017310 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1064539017311 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 1064539017312 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1064539017313 putative active site [active] 1064539017314 putative metal binding site [ion binding]; other site 1064539017315 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1064539017316 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539017317 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1064539017318 metal ion-dependent adhesion site (MIDAS); other site 1064539017319 Virulence factor SrfB; Region: SrfB; pfam07520 1064539017320 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 1064539017321 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064539017322 Sel1 repeat; Region: Sel1; pfam08238 1064539017323 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1064539017324 metal ion-dependent adhesion site (MIDAS); other site 1064539017325 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1064539017326 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1064539017327 Walker A/P-loop; other site 1064539017328 ATP binding site [chemical binding]; other site 1064539017329 Q-loop/lid; other site 1064539017330 ABC transporter signature motif; other site 1064539017331 Walker B; other site 1064539017332 D-loop; other site 1064539017333 H-loop/switch region; other site 1064539017334 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1064539017335 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1064539017336 hypothetical protein; Validated; Region: PRK09039 1064539017337 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1064539017338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539017339 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539017340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1064539017341 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539017342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539017343 dimer interface [polypeptide binding]; other site 1064539017344 putative PBP binding loops; other site 1064539017345 ABC-ATPase subunit interface; other site 1064539017346 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539017347 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539017348 Walker A/P-loop; other site 1064539017349 ATP binding site [chemical binding]; other site 1064539017350 Q-loop/lid; other site 1064539017351 ABC transporter signature motif; other site 1064539017352 Walker B; other site 1064539017353 D-loop; other site 1064539017354 H-loop/switch region; other site 1064539017355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539017356 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539017357 putative substrate translocation pore; other site 1064539017358 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1064539017359 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539017360 substrate binding pocket [chemical binding]; other site 1064539017361 membrane-bound complex binding site; other site 1064539017362 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539017363 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539017364 Ferredoxin [Energy production and conversion]; Region: COG1146 1064539017365 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1064539017366 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1064539017367 putative FMN binding site [chemical binding]; other site 1064539017368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539017369 active site 1064539017370 motif I; other site 1064539017371 motif II; other site 1064539017372 potential frameshift: common BLAST hit: gi|288959816|ref|YP_003450156.1| HAD-superfamily hydrolase, subfamily IIB 1064539017373 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1064539017374 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539017375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539017376 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064539017377 dimerization interface [polypeptide binding]; other site 1064539017378 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539017379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539017380 dimer interface [polypeptide binding]; other site 1064539017381 conserved gate region; other site 1064539017382 putative PBP binding loops; other site 1064539017383 ABC-ATPase subunit interface; other site 1064539017384 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539017385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539017386 Walker A/P-loop; other site 1064539017387 ATP binding site [chemical binding]; other site 1064539017388 Q-loop/lid; other site 1064539017389 ABC transporter signature motif; other site 1064539017390 Walker B; other site 1064539017391 D-loop; other site 1064539017392 H-loop/switch region; other site 1064539017393 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539017394 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1064539017395 substrate binding pocket [chemical binding]; other site 1064539017396 membrane-bound complex binding site; other site 1064539017397 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539017398 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539017399 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1064539017400 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1064539017401 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1064539017402 NAD binding site [chemical binding]; other site 1064539017403 hypothetical protein; Provisional; Region: PRK06208 1064539017404 intersubunit interface [polypeptide binding]; other site 1064539017405 active site 1064539017406 Zn2+ binding site [ion binding]; other site 1064539017407 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1064539017408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539017409 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1064539017410 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1064539017411 active site 1064539017412 PAS domain; Region: PAS; smart00091 1064539017413 PAS domain; Region: PAS_9; pfam13426 1064539017414 putative active site [active] 1064539017415 heme pocket [chemical binding]; other site 1064539017416 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539017417 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539017418 metal binding site [ion binding]; metal-binding site 1064539017419 active site 1064539017420 I-site; other site 1064539017421 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539017422 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8185833; Product type pe : putative enzyme 1064539017423 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8185833; Product type pe : putative enzyme 1064539017424 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1064539017425 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1064539017426 putative active site [active] 1064539017427 putative FMN binding site [chemical binding]; other site 1064539017428 putative substrate binding site [chemical binding]; other site 1064539017429 putative catalytic residue [active] 1064539017430 Recombinase; Region: Recombinase; pfam07508 1064539017431 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 1064539017432 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1064539017433 active site 1064539017434 substrate binding site [chemical binding]; other site 1064539017435 Mg2+ binding site [ion binding]; other site 1064539017436 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539017437 AAA ATPase domain; Region: AAA_16; pfam13191 1064539017438 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539017439 potential frameshift: common BLAST hit: gi|148257617|ref|YP_001242202.1| peptidase 1064539017440 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064539017441 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1064539017442 active site 1064539017443 catalytic residues [active] 1064539017444 Domain of unknown function (DUF4344); Region: DUF4344; pfam14247 1064539017445 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 1064539017446 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1064539017447 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1064539017448 NAD binding site [chemical binding]; other site 1064539017449 substrate binding site [chemical binding]; other site 1064539017450 catalytic Zn binding site [ion binding]; other site 1064539017451 tetramer interface [polypeptide binding]; other site 1064539017452 structural Zn binding site [ion binding]; other site 1064539017453 Gram-negative porin; Region: Porin_4; pfam13609 1064539017454 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1064539017455 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1064539017456 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1064539017457 putative substrate binding site [chemical binding]; other site 1064539017458 nucleotide binding site [chemical binding]; other site 1064539017459 nucleotide binding site [chemical binding]; other site 1064539017460 homodimer interface [polypeptide binding]; other site 1064539017461 ornithine carbamoyltransferase; Validated; Region: PRK02102 1064539017462 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1064539017463 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1064539017464 arginine deiminase; Provisional; Region: PRK01388 1064539017465 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1064539017466 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539017467 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539017468 ligand binding site [chemical binding]; other site 1064539017469 flexible hinge region; other site 1064539017470 FHA domain; Region: FHA; pfam00498 1064539017471 phosphopeptide binding site; other site 1064539017472 putative phosphoketolase; Provisional; Region: PRK05261 1064539017473 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1064539017474 TPP-binding site; other site 1064539017475 XFP C-terminal domain; Region: XFP_C; pfam09363 1064539017476 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1064539017477 homodimer interface [polypeptide binding]; other site 1064539017478 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1064539017479 active site pocket [active] 1064539017480 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1064539017481 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 1064539017482 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1064539017483 active site 1064539017484 catalytic site [active] 1064539017485 potential frameshift: common BLAST hit: gi|254560073|ref|YP_003067168.1| transposase of ISMex10, ISL3 family 1064539017486 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1064539017487 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539017488 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539017489 Walker A/P-loop; other site 1064539017490 ATP binding site [chemical binding]; other site 1064539017491 Q-loop/lid; other site 1064539017492 ABC transporter signature motif; other site 1064539017493 Walker B; other site 1064539017494 D-loop; other site 1064539017495 H-loop/switch region; other site 1064539017496 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539017497 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539017498 Walker A/P-loop; other site 1064539017499 ATP binding site [chemical binding]; other site 1064539017500 Q-loop/lid; other site 1064539017501 ABC transporter signature motif; other site 1064539017502 Walker B; other site 1064539017503 D-loop; other site 1064539017504 H-loop/switch region; other site 1064539017505 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539017506 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539017507 TM-ABC transporter signature motif; other site 1064539017508 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539017509 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539017510 TM-ABC transporter signature motif; other site 1064539017511 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539017512 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539017513 short chain dehydrogenase; Provisional; Region: PRK06125 1064539017514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539017515 NAD(P) binding site [chemical binding]; other site 1064539017516 active site 1064539017517 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1064539017518 Amidase; Region: Amidase; cl11426 1064539017519 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1064539017520 enoyl-CoA hydratase; Provisional; Region: PRK06127 1064539017521 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539017522 substrate binding site [chemical binding]; other site 1064539017523 oxyanion hole (OAH) forming residues; other site 1064539017524 trimer interface [polypeptide binding]; other site 1064539017525 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1064539017526 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064539017527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539017528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539017529 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1064539017530 putative dimerization interface [polypeptide binding]; other site 1064539017531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539017532 sequence-specific DNA binding site [nucleotide binding]; other site 1064539017533 salt bridge; other site 1064539017534 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1064539017535 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1064539017536 catalytic residues [active] 1064539017537 catalytic nucleophile [active] 1064539017538 Recombinase; Region: Recombinase; pfam07508 1064539017539 ParB-like nuclease domain; Region: ParB; smart00470 1064539017540 ParB-like nuclease domain; Region: ParB; smart00470 1064539017541 RepB plasmid partitioning protein; Region: RepB; pfam07506 1064539017542 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064539017543 NACHT domain; Region: NACHT; pfam05729 1064539017544 Homeodomain-like domain; Region: HTH_23; pfam13384 1064539017545 Winged helix-turn helix; Region: HTH_29; pfam13551 1064539017546 Homeodomain-like domain; Region: HTH_32; pfam13565 1064539017547 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1064539017548 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1064539017549 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539017550 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1064539017551 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1064539017552 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539017553 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1064539017554 putative active site [active] 1064539017555 putative metal-binding site [ion binding]; other site 1064539017556 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1064539017557 Part of AAA domain; Region: AAA_19; pfam13245 1064539017558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539017559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539017560 DNA binding site [nucleotide binding] 1064539017561 Predicted integral membrane protein [Function unknown]; Region: COG5616 1064539017562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539017563 TPR motif; other site 1064539017564 TPR repeat; Region: TPR_11; pfam13414 1064539017565 binding surface 1064539017566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539017567 binding surface 1064539017568 TPR motif; other site 1064539017569 TPR repeat; Region: TPR_11; pfam13414 1064539017570 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1064539017571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539017572 NAD(P) binding site [chemical binding]; other site 1064539017573 active site 1064539017574 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1064539017575 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1064539017576 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1064539017577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539017578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539017579 non-specific DNA binding site [nucleotide binding]; other site 1064539017580 salt bridge; other site 1064539017581 sequence-specific DNA binding site [nucleotide binding]; other site 1064539017582 C2 domain; Region: C2; cl14603 1064539017583 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1064539017584 ParB-like nuclease domain; Region: ParB; smart00470 1064539017585 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1064539017586 DNA methylase; Region: N6_N4_Mtase; pfam01555 1064539017587 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1064539017588 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 1064539017589 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 1064539017590 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1064539017591 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1064539017592 catalytic residues [active] 1064539017593 catalytic nucleophile [active] 1064539017594 Presynaptic Site I dimer interface [polypeptide binding]; other site 1064539017595 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1064539017596 Synaptic Flat tetramer interface [polypeptide binding]; other site 1064539017597 Synaptic Site I dimer interface [polypeptide binding]; other site 1064539017598 DNA binding site [nucleotide binding] 1064539017599 Recombinase; Region: Recombinase; pfam07508 1064539017600 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1064539017601 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1064539017602 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 1064539017603 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1064539017604 putative ADP-binding pocket [chemical binding]; other site 1064539017605 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1064539017606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064539017607 active site 1064539017608 motif I; other site 1064539017609 motif II; other site 1064539017610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1064539017611 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1064539017612 Transglycosylase; Region: Transgly; pfam00912 1064539017613 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1064539017614 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1064539017615 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1064539017616 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1064539017617 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1064539017618 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1064539017619 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1064539017620 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1064539017621 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1064539017622 active site 1064539017623 dimer interface [polypeptide binding]; other site 1064539017624 motif 1; other site 1064539017625 motif 2; other site 1064539017626 motif 3; other site 1064539017627 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1064539017628 anticodon binding site; other site 1064539017629 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539017630 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1064539017631 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1064539017632 quinone interaction residues [chemical binding]; other site 1064539017633 active site 1064539017634 catalytic residues [active] 1064539017635 FMN binding site [chemical binding]; other site 1064539017636 substrate binding site [chemical binding]; other site 1064539017637 Protein of unknown function (DUF952); Region: DUF952; cl01393 1064539017638 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1064539017639 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1064539017640 hypothetical protein; Region: PHA00661 1064539017641 hypothetical protein; Region: PHA00662 1064539017642 hypothetical protein; Provisional; Region: PRK11281 1064539017643 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1064539017644 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1064539017645 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1064539017646 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539017647 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539017648 catalytic residue [active] 1064539017649 Phage terminase large subunit; Region: Terminase_3; cl12054 1064539017650 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1064539017651 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1064539017652 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; pfam13876 1064539017653 Helix-turn-helix domain; Region: HTH_36; pfam13730 1064539017654 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539017655 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539017656 non-specific DNA binding site [nucleotide binding]; other site 1064539017657 salt bridge; other site 1064539017658 sequence-specific DNA binding site [nucleotide binding]; other site 1064539017659 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 1064539017660 VRR-NUC domain; Region: VRR_NUC; pfam08774 1064539017661 Herpes virus protein UL24; Region: Herpes_UL24; cl17308 1064539017662 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1064539017663 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 1064539017664 Helix-turn-helix domain; Region: HTH_17; pfam12728 1064539017665 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064539017666 active site 1064539017667 DNA binding site [nucleotide binding] 1064539017668 Int/Topo IB signature motif; other site 1064539017669 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1064539017670 HAMP domain; Region: HAMP; pfam00672 1064539017671 dimerization interface [polypeptide binding]; other site 1064539017672 PAS domain S-box; Region: sensory_box; TIGR00229 1064539017673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539017674 putative active site [active] 1064539017675 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539017676 metal binding site [ion binding]; metal-binding site 1064539017677 active site 1064539017678 I-site; other site 1064539017679 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539017680 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 1064539017681 hypothetical protein; Region: PHA00670 1064539017682 Predicted transcriptional regulator [Transcription]; Region: COG2932 1064539017683 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1064539017684 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1064539017685 Catalytic site [active] 1064539017686 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1064539017687 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1064539017688 homodimer interface [polypeptide binding]; other site 1064539017689 substrate-cofactor binding pocket; other site 1064539017690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539017691 catalytic residue [active] 1064539017692 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1064539017693 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1064539017694 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10373108, 2668268, 6388571, 7037404; Product type e : enzyme 1064539017695 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10373108, 2668268, 6388571, 7037404; Product type e : enzyme 1064539017696 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 1064539017697 putative SdhC subunit interface [polypeptide binding]; other site 1064539017698 putative proximal heme binding site [chemical binding]; other site 1064539017699 putative Iron-sulfur protein interface [polypeptide binding]; other site 1064539017700 putative proximal quinone binding site; other site 1064539017701 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1064539017702 Iron-sulfur protein interface; other site 1064539017703 proximal quinone binding site [chemical binding]; other site 1064539017704 SdhD (CybS) interface [polypeptide binding]; other site 1064539017705 proximal heme binding site [chemical binding]; other site 1064539017706 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1064539017707 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1064539017708 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1064539017709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539017710 Coenzyme A binding pocket [chemical binding]; other site 1064539017711 potential frameshift: common BLAST hit: gi|374292887|ref|YP_005039922.1| tartronate semialdehyde reductase 1064539017712 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1064539017713 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064539017714 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064539017715 tellurite resistance protein terB; Region: terB; cd07176 1064539017716 putative metal binding site [ion binding]; other site 1064539017717 Predicted permeases [General function prediction only]; Region: COG0679 1064539017718 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1064539017719 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539017720 dimerization interface [polypeptide binding]; other site 1064539017721 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539017722 dimer interface [polypeptide binding]; other site 1064539017723 putative CheW interface [polypeptide binding]; other site 1064539017724 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1064539017725 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1064539017726 proposed active site lysine [active] 1064539017727 conserved cys residue [active] 1064539017728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539017729 non-specific DNA binding site [nucleotide binding]; other site 1064539017730 salt bridge; other site 1064539017731 sequence-specific DNA binding site [nucleotide binding]; other site 1064539017732 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1064539017733 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1064539017734 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539017735 dimerization interface [polypeptide binding]; other site 1064539017736 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539017737 putative CheW interface [polypeptide binding]; other site 1064539017738 potential frameshift: common BLAST hit: gi|374292892|ref|YP_005039927.1| putative ATP-dependent DNA helicase 1064539017739 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1064539017740 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1064539017741 Transglycosylase; Region: Transgly; cl17702 1064539017742 potential frameshift: common BLAST hit: gi|374292893|ref|YP_005039928.1| biosynthetic peptidoglycan transglycosylase 1064539017743 Transglycosylase; Region: Transgly; cl17702 1064539017744 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1064539017745 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 1064539017746 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1064539017747 active site 1064539017748 nucleotide binding site [chemical binding]; other site 1064539017749 HIGH motif; other site 1064539017750 KMSKS motif; other site 1064539017751 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1064539017752 malate dehydrogenase; Reviewed; Region: PRK06223 1064539017753 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1064539017754 NAD(P) binding site [chemical binding]; other site 1064539017755 dimer interface [polypeptide binding]; other site 1064539017756 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1064539017757 substrate binding site [chemical binding]; other site 1064539017758 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1064539017759 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1064539017760 CoA-ligase; Region: Ligase_CoA; pfam00549 1064539017761 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1064539017762 CoA binding domain; Region: CoA_binding; pfam02629 1064539017763 CoA-ligase; Region: Ligase_CoA; pfam00549 1064539017764 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1064539017765 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1064539017766 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1064539017767 TPP-binding site [chemical binding]; other site 1064539017768 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1064539017769 PYR/PP interface [polypeptide binding]; other site 1064539017770 dimer interface [polypeptide binding]; other site 1064539017771 TPP binding site [chemical binding]; other site 1064539017772 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1064539017773 E3 interaction surface; other site 1064539017774 lipoyl attachment site [posttranslational modification]; other site 1064539017775 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1064539017776 e3 binding domain; Region: E3_binding; pfam02817 1064539017777 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1064539017778 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539017779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539017780 putative active site [active] 1064539017781 heme pocket [chemical binding]; other site 1064539017782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539017783 dimer interface [polypeptide binding]; other site 1064539017784 phosphorylation site [posttranslational modification] 1064539017785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539017786 ATP binding site [chemical binding]; other site 1064539017787 Mg2+ binding site [ion binding]; other site 1064539017788 G-X-G motif; other site 1064539017789 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1064539017790 heme-binding site [chemical binding]; other site 1064539017791 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539017792 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539017793 metal binding site [ion binding]; metal-binding site 1064539017794 active site 1064539017795 I-site; other site 1064539017796 Predicted ATPase [General function prediction only]; Region: COG1485 1064539017797 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1064539017798 pyridoxamine kinase; Validated; Region: PRK05756 1064539017799 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1064539017800 dimer interface [polypeptide binding]; other site 1064539017801 pyridoxal binding site [chemical binding]; other site 1064539017802 ATP binding site [chemical binding]; other site 1064539017803 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1064539017804 General stress protein [General function prediction only]; Region: GsiB; COG3729 1064539017805 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1064539017806 tartrate dehydrogenase; Region: TTC; TIGR02089 1064539017807 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1064539017808 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1064539017809 substrate binding site [chemical binding]; other site 1064539017810 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1064539017811 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1064539017812 Ligand binding site; other site 1064539017813 Putative Catalytic site; other site 1064539017814 DXD motif; other site 1064539017815 GtrA-like protein; Region: GtrA; pfam04138 1064539017816 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1064539017817 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1064539017818 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1064539017819 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1064539017820 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1064539017821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539017822 FeS/SAM binding site; other site 1064539017823 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1064539017824 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539017825 AMP nucleosidase; Provisional; Region: PRK08292 1064539017826 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1064539017827 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1064539017828 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 1064539017829 intracellular septation protein A; Reviewed; Region: PRK00259 1064539017830 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1064539017831 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1064539017832 active site 1064539017833 catalytic site [active] 1064539017834 tetramer interface [polypeptide binding]; other site 1064539017835 Sporulation related domain; Region: SPOR; pfam05036 1064539017836 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539017837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017838 active site 1064539017839 phosphorylation site [posttranslational modification] 1064539017840 intermolecular recognition site; other site 1064539017841 dimerization interface [polypeptide binding]; other site 1064539017842 PAS domain; Region: PAS; smart00091 1064539017843 PAS domain; Region: PAS_9; pfam13426 1064539017844 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1064539017845 active site 1064539017846 catalytic site [active] 1064539017847 substrate binding site [chemical binding]; other site 1064539017848 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1064539017849 Na binding site [ion binding]; other site 1064539017850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539017851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539017852 dimer interface [polypeptide binding]; other site 1064539017853 phosphorylation site [posttranslational modification] 1064539017854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539017855 ATP binding site [chemical binding]; other site 1064539017856 Mg2+ binding site [ion binding]; other site 1064539017857 G-X-G motif; other site 1064539017858 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1064539017859 anti sigma factor interaction site; other site 1064539017860 regulatory phosphorylation site [posttranslational modification]; other site 1064539017861 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539017862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017863 active site 1064539017864 phosphorylation site [posttranslational modification] 1064539017865 intermolecular recognition site; other site 1064539017866 dimerization interface [polypeptide binding]; other site 1064539017867 potential frameshift: common BLAST hit: gi|374292814|ref|YP_005039849.1| Chemotaxis sensor histidine kinase CheA 1064539017868 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064539017869 putative binding surface; other site 1064539017870 active site 1064539017871 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1064539017872 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1064539017873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539017874 ATP binding site [chemical binding]; other site 1064539017875 Mg2+ binding site [ion binding]; other site 1064539017876 G-X-G motif; other site 1064539017877 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1064539017878 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1064539017879 putative CheA interaction surface; other site 1064539017880 HAMP domain; Region: HAMP; pfam00672 1064539017881 PAS fold; Region: PAS_4; pfam08448 1064539017882 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1064539017883 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539017884 dimer interface [polypeptide binding]; other site 1064539017885 putative CheW interface [polypeptide binding]; other site 1064539017886 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1064539017887 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1064539017888 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1064539017889 CheD chemotactic sensory transduction; Region: CheD; cl00810 1064539017890 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1064539017891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017892 active site 1064539017893 phosphorylation site [posttranslational modification] 1064539017894 intermolecular recognition site; other site 1064539017895 dimerization interface [polypeptide binding]; other site 1064539017896 CheB methylesterase; Region: CheB_methylest; pfam01339 1064539017897 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539017898 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539017899 dimer interface [polypeptide binding]; other site 1064539017900 putative CheW interface [polypeptide binding]; other site 1064539017901 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1064539017902 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1064539017903 anti sigma factor interaction site; other site 1064539017904 regulatory phosphorylation site [posttranslational modification]; other site 1064539017905 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1064539017906 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1064539017907 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539017908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017909 active site 1064539017910 phosphorylation site [posttranslational modification] 1064539017911 intermolecular recognition site; other site 1064539017912 dimerization interface [polypeptide binding]; other site 1064539017913 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1064539017914 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1064539017915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017916 active site 1064539017917 phosphorylation site [posttranslational modification] 1064539017918 intermolecular recognition site; other site 1064539017919 dimerization interface [polypeptide binding]; other site 1064539017920 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1064539017921 PIN domain; Region: PIN_3; cl17397 1064539017922 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1064539017923 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1064539017924 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539017925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017926 active site 1064539017927 phosphorylation site [posttranslational modification] 1064539017928 intermolecular recognition site; other site 1064539017929 dimerization interface [polypeptide binding]; other site 1064539017930 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1064539017931 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1064539017932 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1064539017933 anti sigma factor interaction site; other site 1064539017934 regulatory phosphorylation site [posttranslational modification]; other site 1064539017935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1064539017936 dimerization interface [polypeptide binding]; other site 1064539017937 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539017938 PAS fold; Region: PAS_3; pfam08447 1064539017939 putative active site [active] 1064539017940 heme pocket [chemical binding]; other site 1064539017941 PAS fold; Region: PAS_7; pfam12860 1064539017942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539017943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539017944 ATP binding site [chemical binding]; other site 1064539017945 Mg2+ binding site [ion binding]; other site 1064539017946 G-X-G motif; other site 1064539017947 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539017948 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539017949 putative active site [active] 1064539017950 heme pocket [chemical binding]; other site 1064539017951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539017952 dimer interface [polypeptide binding]; other site 1064539017953 phosphorylation site [posttranslational modification] 1064539017954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539017955 ATP binding site [chemical binding]; other site 1064539017956 Mg2+ binding site [ion binding]; other site 1064539017957 G-X-G motif; other site 1064539017958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539017959 active site 1064539017960 phosphorylation site [posttranslational modification] 1064539017961 intermolecular recognition site; other site 1064539017962 Hpt domain; Region: Hpt; pfam01627 1064539017963 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 1064539017964 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1064539017965 metal binding site 2 [ion binding]; metal-binding site 1064539017966 putative DNA binding helix; other site 1064539017967 metal binding site 1 [ion binding]; metal-binding site 1064539017968 dimer interface [polypeptide binding]; other site 1064539017969 structural Zn2+ binding site [ion binding]; other site 1064539017970 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1064539017971 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1064539017972 ATP binding site [chemical binding]; other site 1064539017973 Mg++ binding site [ion binding]; other site 1064539017974 motif III; other site 1064539017975 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064539017976 nucleotide binding region [chemical binding]; other site 1064539017977 ATP-binding site [chemical binding]; other site 1064539017978 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539017979 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1064539017980 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064539017981 putative metal binding site [ion binding]; other site 1064539017982 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1064539017983 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064539017984 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1064539017985 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 1064539017986 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 1064539017987 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1064539017988 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1064539017989 active site 1064539017990 catalytic residues [active] 1064539017991 metal binding site [ion binding]; metal-binding site 1064539017992 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1064539017993 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1064539017994 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1064539017995 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1064539017996 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1064539017997 carboxyltransferase (CT) interaction site; other site 1064539017998 biotinylation site [posttranslational modification]; other site 1064539017999 enoyl-CoA hydratase; Provisional; Region: PRK05995 1064539018000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539018001 substrate binding site [chemical binding]; other site 1064539018002 oxyanion hole (OAH) forming residues; other site 1064539018003 trimer interface [polypeptide binding]; other site 1064539018004 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1064539018005 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1064539018006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539018007 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1064539018008 FAD binding site [chemical binding]; other site 1064539018009 homotetramer interface [polypeptide binding]; other site 1064539018010 substrate binding pocket [chemical binding]; other site 1064539018011 catalytic base [active] 1064539018012 potential frameshift: common BLAST hit: gi|374998043|ref|YP_004973542.1| acetyl-CoA acetyltransferase with thiolase domain 1064539018013 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1064539018014 active site 1064539018015 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1064539018016 dimer interface [polypeptide binding]; other site 1064539018017 isovaleryl-CoA dehydrogenase; Region: PLN02519 1064539018018 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1064539018019 substrate binding site [chemical binding]; other site 1064539018020 FAD binding site [chemical binding]; other site 1064539018021 catalytic base [active] 1064539018022 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1064539018023 Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108 1064539018024 NAD(P) binding site [chemical binding]; other site 1064539018025 catalytic residues [active] 1064539018026 catalytic residues [active] 1064539018027 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539018028 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539018029 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539018030 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539018031 Walker A/P-loop; other site 1064539018032 ATP binding site [chemical binding]; other site 1064539018033 Q-loop/lid; other site 1064539018034 ABC transporter signature motif; other site 1064539018035 Walker B; other site 1064539018036 D-loop; other site 1064539018037 H-loop/switch region; other site 1064539018038 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539018039 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1064539018040 putative ligand binding site [chemical binding]; other site 1064539018041 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1064539018042 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539018043 TM-ABC transporter signature motif; other site 1064539018044 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064539018045 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539018046 TM-ABC transporter signature motif; other site 1064539018047 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1064539018048 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1064539018049 acyl-activating enzyme (AAE) consensus motif; other site 1064539018050 putative AMP binding site [chemical binding]; other site 1064539018051 putative active site [active] 1064539018052 putative CoA binding site [chemical binding]; other site 1064539018053 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539018054 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539018055 Walker A/P-loop; other site 1064539018056 ATP binding site [chemical binding]; other site 1064539018057 Q-loop/lid; other site 1064539018058 ABC transporter signature motif; other site 1064539018059 Walker B; other site 1064539018060 D-loop; other site 1064539018061 H-loop/switch region; other site 1064539018062 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539018063 AMP-binding enzyme; Region: AMP-binding; pfam00501 1064539018064 acyl-activating enzyme (AAE) consensus motif; other site 1064539018065 active site 1064539018066 AMP binding site [chemical binding]; other site 1064539018067 CoA binding site [chemical binding]; other site 1064539018068 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064539018069 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1064539018070 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539018071 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1064539018072 substrate binding pocket [chemical binding]; other site 1064539018073 FAD binding site [chemical binding]; other site 1064539018074 catalytic base [active] 1064539018075 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539018076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539018077 DNA-binding site [nucleotide binding]; DNA binding site 1064539018078 FCD domain; Region: FCD; pfam07729 1064539018079 malonyl-CoA synthase; Validated; Region: PRK07514 1064539018080 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 1064539018081 acyl-activating enzyme (AAE) consensus motif; other site 1064539018082 active site 1064539018083 AMP binding site [chemical binding]; other site 1064539018084 CoA binding site [chemical binding]; other site 1064539018085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539018086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539018087 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1064539018088 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 1064539018089 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 1064539018090 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1064539018091 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1064539018092 NAD binding site [chemical binding]; other site 1064539018093 homodimer interface [polypeptide binding]; other site 1064539018094 active site 1064539018095 substrate binding site [chemical binding]; other site 1064539018096 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1064539018097 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539018098 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1064539018099 Walker A/P-loop; other site 1064539018100 ATP binding site [chemical binding]; other site 1064539018101 Q-loop/lid; other site 1064539018102 ABC transporter signature motif; other site 1064539018103 Walker B; other site 1064539018104 D-loop; other site 1064539018105 H-loop/switch region; other site 1064539018106 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1064539018107 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539018108 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539018109 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539018110 potential frameshift: common BLAST hit: gi|374999176|ref|YP_004974674.1| Putative glycosyl transferase, family 2 1064539018111 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1064539018112 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539018113 active site 1064539018114 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1064539018115 Probable Catalytic site; other site 1064539018116 metal-binding site 1064539018117 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539018118 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539018119 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 1064539018120 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539018121 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 1064539018122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539018123 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1064539018124 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1064539018125 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539018126 Evidence 4 : Homologs of previously reported genes of unknown function 1064539018127 Evidence 4 : Homologs of previously reported genes of unknown function 1064539018128 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1064539018129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1064539018130 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1064539018131 FOG: CBS domain [General function prediction only]; Region: COG0517 1064539018132 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1064539018133 BON domain; Region: BON; pfam04972 1064539018134 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539018135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539018136 DNA-binding site [nucleotide binding]; DNA binding site 1064539018137 FCD domain; Region: FCD; pfam07729 1064539018138 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1064539018139 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1064539018140 tetrameric interface [polypeptide binding]; other site 1064539018141 NAD binding site [chemical binding]; other site 1064539018142 catalytic residues [active] 1064539018143 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1064539018144 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064539018145 inhibitor-cofactor binding pocket; inhibition site 1064539018146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539018147 catalytic residue [active] 1064539018148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539018149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539018150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064539018151 dimerization interface [polypeptide binding]; other site 1064539018152 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1064539018153 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1064539018154 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1064539018155 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539018156 DNA-binding site [nucleotide binding]; DNA binding site 1064539018157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539018158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539018159 homodimer interface [polypeptide binding]; other site 1064539018160 catalytic residue [active] 1064539018161 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1064539018162 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1064539018163 active site 1064539018164 dimer interface [polypeptide binding]; other site 1064539018165 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1064539018166 Ligand Binding Site [chemical binding]; other site 1064539018167 Molecular Tunnel; other site 1064539018168 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1064539018169 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1064539018170 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1064539018171 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1064539018172 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1064539018173 putative oligomer interface [polypeptide binding]; other site 1064539018174 putative active site [active] 1064539018175 metal binding site [ion binding]; metal-binding site 1064539018176 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539018177 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 1064539018178 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1064539018179 Carbon starvation protein CstA; Region: CstA; pfam02554 1064539018180 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1064539018181 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1064539018182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539018183 active site 1064539018184 phosphorylation site [posttranslational modification] 1064539018185 intermolecular recognition site; other site 1064539018186 dimerization interface [polypeptide binding]; other site 1064539018187 LytTr DNA-binding domain; Region: LytTR; smart00850 1064539018188 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1064539018189 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1064539018190 GAF domain; Region: GAF; pfam01590 1064539018191 Histidine kinase; Region: His_kinase; pfam06580 1064539018192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539018193 ATP binding site [chemical binding]; other site 1064539018194 Mg2+ binding site [ion binding]; other site 1064539018195 G-X-G motif; other site 1064539018196 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1064539018197 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1064539018198 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1064539018199 active site 1064539018200 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 1064539018201 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1064539018202 potential frameshift: common BLAST hit: gi|375006583|ref|YP_004975367.1| membrane spanning protein in TonB-ExbB-ExbD complex 1064539018203 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1064539018204 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1064539018205 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1064539018206 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1064539018207 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1064539018208 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1064539018209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539018210 active site 1064539018211 phosphorylation site [posttranslational modification] 1064539018212 intermolecular recognition site; other site 1064539018213 dimerization interface [polypeptide binding]; other site 1064539018214 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539018215 DNA binding residues [nucleotide binding] 1064539018216 dimerization interface [polypeptide binding]; other site 1064539018217 MASE1; Region: MASE1; cl17823 1064539018218 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539018219 dimer interface [polypeptide binding]; other site 1064539018220 phosphorylation site [posttranslational modification] 1064539018221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539018222 ATP binding site [chemical binding]; other site 1064539018223 Mg2+ binding site [ion binding]; other site 1064539018224 G-X-G motif; other site 1064539018225 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1064539018226 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1064539018227 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1064539018228 NAD(P) binding site [chemical binding]; other site 1064539018229 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1064539018230 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1064539018231 Troponin; Region: Troponin; pfam00992 1064539018232 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1064539018233 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064539018234 MarR family; Region: MarR_2; pfam12802 1064539018235 PAS domain; Region: PAS_9; pfam13426 1064539018236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539018237 putative active site [active] 1064539018238 heme pocket [chemical binding]; other site 1064539018239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539018240 PAS domain; Region: PAS_9; pfam13426 1064539018241 putative active site [active] 1064539018242 heme pocket [chemical binding]; other site 1064539018243 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539018244 dimer interface [polypeptide binding]; other site 1064539018245 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1064539018246 putative CheW interface [polypeptide binding]; other site 1064539018247 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539018248 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539018249 substrate binding pocket [chemical binding]; other site 1064539018250 membrane-bound complex binding site; other site 1064539018251 hinge residues; other site 1064539018252 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539018253 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539018254 substrate binding pocket [chemical binding]; other site 1064539018255 membrane-bound complex binding site; other site 1064539018256 hinge residues; other site 1064539018257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539018258 dimer interface [polypeptide binding]; other site 1064539018259 phosphorylation site [posttranslational modification] 1064539018260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539018261 ATP binding site [chemical binding]; other site 1064539018262 Mg2+ binding site [ion binding]; other site 1064539018263 G-X-G motif; other site 1064539018264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539018265 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539018266 active site 1064539018267 phosphorylation site [posttranslational modification] 1064539018268 intermolecular recognition site; other site 1064539018269 dimerization interface [polypeptide binding]; other site 1064539018270 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539018271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539018272 active site 1064539018273 phosphorylation site [posttranslational modification] 1064539018274 intermolecular recognition site; other site 1064539018275 dimerization interface [polypeptide binding]; other site 1064539018276 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064539018277 putative binding surface; other site 1064539018278 active site 1064539018279 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539018280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539018281 active site 1064539018282 phosphorylation site [posttranslational modification] 1064539018283 intermolecular recognition site; other site 1064539018284 dimerization interface [polypeptide binding]; other site 1064539018285 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539018286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539018287 active site 1064539018288 phosphorylation site [posttranslational modification] 1064539018289 intermolecular recognition site; other site 1064539018290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539018291 dimerization interface [polypeptide binding]; other site 1064539018292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539018293 ATP binding site [chemical binding]; other site 1064539018294 Mg2+ binding site [ion binding]; other site 1064539018295 G-X-G motif; other site 1064539018296 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1064539018297 classical (c) SDRs; Region: SDR_c; cd05233 1064539018298 NAD(P) binding site [chemical binding]; other site 1064539018299 active site 1064539018300 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1064539018301 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1064539018302 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1064539018303 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1064539018304 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1064539018305 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1064539018306 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1064539018307 active site 1064539018308 intersubunit interface [polypeptide binding]; other site 1064539018309 catalytic residue [active] 1064539018310 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 381020; Product type e : enzyme 1064539018311 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 381020; Product type e : enzyme 1064539018312 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064539018313 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064539018314 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539018315 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1064539018316 Clp amino terminal domain; Region: Clp_N; pfam02861 1064539018317 Clp amino terminal domain; Region: Clp_N; pfam02861 1064539018318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539018319 Walker A motif; other site 1064539018320 ATP binding site [chemical binding]; other site 1064539018321 Walker B motif; other site 1064539018322 arginine finger; other site 1064539018323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539018324 Walker A motif; other site 1064539018325 ATP binding site [chemical binding]; other site 1064539018326 Walker B motif; other site 1064539018327 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1064539018328 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1064539018329 Amidase; Region: Amidase; pfam01425 1064539018330 dihydropyrimidinase; Provisional; Region: PRK13404 1064539018331 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1064539018332 tetramer interface [polypeptide binding]; other site 1064539018333 active site 1064539018334 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1064539018335 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 1064539018336 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1064539018337 active site 1064539018338 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539018339 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1064539018340 Walker A/P-loop; other site 1064539018341 ATP binding site [chemical binding]; other site 1064539018342 Q-loop/lid; other site 1064539018343 ABC transporter signature motif; other site 1064539018344 Walker B; other site 1064539018345 D-loop; other site 1064539018346 H-loop/switch region; other site 1064539018347 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539018348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539018349 dimer interface [polypeptide binding]; other site 1064539018350 conserved gate region; other site 1064539018351 putative PBP binding loops; other site 1064539018352 ABC-ATPase subunit interface; other site 1064539018353 NMT1-like family; Region: NMT1_2; pfam13379 1064539018354 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1064539018355 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539018356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539018357 DNA-binding site [nucleotide binding]; DNA binding site 1064539018358 FCD domain; Region: FCD; pfam07729 1064539018359 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1064539018360 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 1064539018361 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1064539018362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539018363 Walker A/P-loop; other site 1064539018364 ATP binding site [chemical binding]; other site 1064539018365 Q-loop/lid; other site 1064539018366 ABC transporter signature motif; other site 1064539018367 Walker B; other site 1064539018368 D-loop; other site 1064539018369 H-loop/switch region; other site 1064539018370 TOBE domain; Region: TOBE_2; pfam08402 1064539018371 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064539018372 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1064539018373 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1064539018374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539018375 dimer interface [polypeptide binding]; other site 1064539018376 conserved gate region; other site 1064539018377 putative PBP binding loops; other site 1064539018378 ABC-ATPase subunit interface; other site 1064539018379 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064539018380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539018381 dimer interface [polypeptide binding]; other site 1064539018382 conserved gate region; other site 1064539018383 putative PBP binding loops; other site 1064539018384 ABC-ATPase subunit interface; other site 1064539018385 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1064539018386 active site 1064539018387 homotetramer interface [polypeptide binding]; other site 1064539018388 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1064539018389 Amidase; Region: Amidase; cl11426 1064539018390 PAS fold; Region: PAS_4; pfam08448 1064539018391 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539018392 putative active site [active] 1064539018393 heme pocket [chemical binding]; other site 1064539018394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539018395 PAS fold; Region: PAS_3; pfam08447 1064539018396 putative active site [active] 1064539018397 heme pocket [chemical binding]; other site 1064539018398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539018399 PAS fold; Region: PAS_3; pfam08447 1064539018400 putative active site [active] 1064539018401 heme pocket [chemical binding]; other site 1064539018402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539018403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539018404 dimer interface [polypeptide binding]; other site 1064539018405 phosphorylation site [posttranslational modification] 1064539018406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539018407 ATP binding site [chemical binding]; other site 1064539018408 Mg2+ binding site [ion binding]; other site 1064539018409 G-X-G motif; other site 1064539018410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539018411 S-adenosylmethionine binding site [chemical binding]; other site 1064539018412 conserved hypothetical protein; Region: MG423; TIGR00649 1064539018413 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064539018414 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1064539018415 BON domain; Region: BON; pfam04972 1064539018416 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1064539018417 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1064539018418 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539018419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539018420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1064539018421 active site 1064539018422 intermolecular recognition site; other site 1064539018423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539018424 DNA binding residues [nucleotide binding] 1064539018425 dimerization interface [polypeptide binding]; other site 1064539018426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539018427 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539018428 DNA binding residues [nucleotide binding] 1064539018429 dimerization interface [polypeptide binding]; other site 1064539018430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539018431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1064539018432 active site 1064539018433 phosphorylation site [posttranslational modification] 1064539018434 intermolecular recognition site; other site 1064539018435 dimerization interface [polypeptide binding]; other site 1064539018436 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539018437 DNA binding residues [nucleotide binding] 1064539018438 dimerization interface [polypeptide binding]; other site 1064539018439 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1064539018440 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1064539018441 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1064539018442 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1064539018443 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1064539018444 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539018445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539018446 NAD(P) binding site [chemical binding]; other site 1064539018447 active site 1064539018448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539018449 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539018450 NAD(P) binding site [chemical binding]; other site 1064539018451 active site 1064539018452 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539018453 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1064539018454 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1064539018455 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1064539018456 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 1064539018457 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1064539018458 NAD binding site [chemical binding]; other site 1064539018459 homotetramer interface [polypeptide binding]; other site 1064539018460 homodimer interface [polypeptide binding]; other site 1064539018461 active site 1064539018462 substrate binding site [chemical binding]; other site 1064539018463 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1064539018464 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1064539018465 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1064539018466 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1064539018467 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064539018468 NAD binding site [chemical binding]; other site 1064539018469 putative substrate binding site 2 [chemical binding]; other site 1064539018470 putative substrate binding site 1 [chemical binding]; other site 1064539018471 active site 1064539018472 potential frameshift: common BLAST hit: gi|209967243|ref|YP_002300158.1| succinoglycan biosynthesis transport protein ExoP 1064539018473 Chain length determinant protein; Region: Wzz; cl15801 1064539018474 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1064539018475 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064539018476 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1064539018477 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064539018478 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1064539018479 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1064539018480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539018481 NAD(P) binding site [chemical binding]; other site 1064539018482 active site 1064539018483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539018484 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1064539018485 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539018486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539018487 O-Antigen ligase; Region: Wzy_C; cl04850 1064539018488 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1064539018489 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064539018490 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1064539018491 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1064539018492 inhibitor-cofactor binding pocket; inhibition site 1064539018493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539018494 catalytic residue [active] 1064539018495 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539018496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539018497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539018498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064539018499 dimerization interface [polypeptide binding]; other site 1064539018500 acetylornithine deacetylase; Provisional; Region: PRK06837 1064539018501 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1064539018502 metal binding site [ion binding]; metal-binding site 1064539018503 dimer interface [polypeptide binding]; other site 1064539018504 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1064539018505 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1064539018506 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539018507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539018508 dimer interface [polypeptide binding]; other site 1064539018509 conserved gate region; other site 1064539018510 putative PBP binding loops; other site 1064539018511 ABC-ATPase subunit interface; other site 1064539018512 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1064539018513 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1064539018514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539018515 dimer interface [polypeptide binding]; other site 1064539018516 conserved gate region; other site 1064539018517 ABC-ATPase subunit interface; other site 1064539018518 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1064539018519 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539018520 Walker A/P-loop; other site 1064539018521 ATP binding site [chemical binding]; other site 1064539018522 Q-loop/lid; other site 1064539018523 ABC transporter signature motif; other site 1064539018524 Walker B; other site 1064539018525 D-loop; other site 1064539018526 H-loop/switch region; other site 1064539018527 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1064539018528 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539018529 Walker A/P-loop; other site 1064539018530 ATP binding site [chemical binding]; other site 1064539018531 Q-loop/lid; other site 1064539018532 ABC transporter signature motif; other site 1064539018533 Walker B; other site 1064539018534 D-loop; other site 1064539018535 H-loop/switch region; other site 1064539018536 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539018537 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1064539018538 allantoate amidohydrolase; Reviewed; Region: PRK12893 1064539018539 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1064539018540 active site 1064539018541 metal binding site [ion binding]; metal-binding site 1064539018542 dimer interface [polypeptide binding]; other site 1064539018543 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1064539018544 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1064539018545 active site 1064539018546 Zn binding site [ion binding]; other site 1064539018547 hypothetical protein; Validated; Region: PRK07586 1064539018548 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1064539018549 PYR/PP interface [polypeptide binding]; other site 1064539018550 dimer interface [polypeptide binding]; other site 1064539018551 TPP binding site [chemical binding]; other site 1064539018552 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1064539018553 TPP-binding site [chemical binding]; other site 1064539018554 dimer interface [polypeptide binding]; other site 1064539018555 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1064539018556 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539018557 EamA-like transporter family; Region: EamA; pfam00892 1064539018558 EamA-like transporter family; Region: EamA; pfam00892 1064539018559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064539018560 DNA binding site [nucleotide binding] 1064539018561 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1064539018562 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1064539018563 putative ligand binding site [chemical binding]; other site 1064539018564 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539018565 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539018566 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1809844, 9287004; Product type pt : putative transporter 1064539018567 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1809844, 9287004; Product type pt : putative transporter 1064539018568 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1064539018569 dimer interface [polypeptide binding]; other site 1064539018570 substrate binding site [chemical binding]; other site 1064539018571 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 1064539018572 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 1064539018573 dimer interface [polypeptide binding]; other site 1064539018574 active site 1064539018575 catalytic residue [active] 1064539018576 metal binding site [ion binding]; metal-binding site 1064539018577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1064539018578 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 1064539018579 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539018580 ligand binding site [chemical binding]; other site 1064539018581 flexible hinge region; other site 1064539018582 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1064539018583 non-specific DNA interactions [nucleotide binding]; other site 1064539018584 DNA binding site [nucleotide binding] 1064539018585 sequence specific DNA binding site [nucleotide binding]; other site 1064539018586 putative cAMP binding site [chemical binding]; other site 1064539018587 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539018588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539018589 active site 1064539018590 phosphorylation site [posttranslational modification] 1064539018591 intermolecular recognition site; other site 1064539018592 dimerization interface [polypeptide binding]; other site 1064539018593 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1064539018594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539018595 putative substrate translocation pore; other site 1064539018596 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 1064539018597 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1064539018598 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1064539018599 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1064539018600 NapD protein; Region: NapD; pfam03927 1064539018601 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1064539018602 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1064539018603 [4Fe-4S] binding site [ion binding]; other site 1064539018604 molybdopterin cofactor binding site; other site 1064539018605 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1064539018606 molybdopterin cofactor binding site; other site 1064539018607 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 1064539018608 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 1064539018609 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 1064539018610 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1064539018611 IHF dimer interface [polypeptide binding]; other site 1064539018612 IHF - DNA interface [nucleotide binding]; other site 1064539018613 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1064539018614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539018615 active site 1064539018616 phosphorylation site [posttranslational modification] 1064539018617 intermolecular recognition site; other site 1064539018618 dimerization interface [polypeptide binding]; other site 1064539018619 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064539018620 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539018621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539018622 dimer interface [polypeptide binding]; other site 1064539018623 phosphorylation site [posttranslational modification] 1064539018624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539018625 ATP binding site [chemical binding]; other site 1064539018626 Mg2+ binding site [ion binding]; other site 1064539018627 G-X-G motif; other site 1064539018628 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1064539018629 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1064539018630 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1064539018631 Subunit I/III interface [polypeptide binding]; other site 1064539018632 Subunit III/IV interface [polypeptide binding]; other site 1064539018633 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1064539018634 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1064539018635 D-pathway; other site 1064539018636 Putative ubiquinol binding site [chemical binding]; other site 1064539018637 Low-spin heme (heme b) binding site [chemical binding]; other site 1064539018638 Putative water exit pathway; other site 1064539018639 Binuclear center (heme o3/CuB) [ion binding]; other site 1064539018640 K-pathway; other site 1064539018641 Putative proton exit pathway; other site 1064539018642 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1064539018643 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1064539018644 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1064539018645 metabolite-proton symporter; Region: 2A0106; TIGR00883 1064539018646 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1064539018647 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1064539018648 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1064539018649 putative substrate binding site [chemical binding]; other site 1064539018650 putative ATP binding site [chemical binding]; other site 1064539018651 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064539018652 catalytic core [active] 1064539018653 PAS fold; Region: PAS_4; pfam08448 1064539018654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539018655 putative active site [active] 1064539018656 heme pocket [chemical binding]; other site 1064539018657 PAS fold; Region: PAS_4; pfam08448 1064539018658 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539018659 putative active site [active] 1064539018660 heme pocket [chemical binding]; other site 1064539018661 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064539018662 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064539018663 metal binding site [ion binding]; metal-binding site 1064539018664 active site 1064539018665 I-site; other site 1064539018666 BCCT family transporter; Region: BCCT; pfam02028 1064539018667 Predicted integral membrane protein [Function unknown]; Region: COG0392 1064539018668 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1064539018669 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1064539018670 SapC; Region: SapC; pfam07277 1064539018671 Plasmodium Vir superfamily; Provisional; Region: PTZ00473 1064539018672 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1064539018673 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1064539018674 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1064539018675 Surface antigen; Region: Bac_surface_Ag; pfam01103 1064539018676 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1064539018677 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1064539018678 DAK2 domain; Region: Dak2; pfam02734 1064539018679 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1064539018680 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1064539018681 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064539018682 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064539018683 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539018684 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1064539018685 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1064539018686 inhibitor site; inhibition site 1064539018687 active site 1064539018688 dimer interface [polypeptide binding]; other site 1064539018689 catalytic residue [active] 1064539018690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1064539018691 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1064539018692 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1064539018693 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 1064539018694 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1064539018695 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1064539018696 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539018697 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539018698 DNA binding residues [nucleotide binding] 1064539018699 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1064539018700 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539018701 N-terminal plug; other site 1064539018702 ligand-binding site [chemical binding]; other site 1064539018703 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1064539018704 FecR protein; Region: FecR; pfam04773 1064539018705 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539018706 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1064539018707 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1064539018708 Walker A/P-loop; other site 1064539018709 ATP binding site [chemical binding]; other site 1064539018710 Q-loop/lid; other site 1064539018711 ABC transporter signature motif; other site 1064539018712 Walker B; other site 1064539018713 D-loop; other site 1064539018714 H-loop/switch region; other site 1064539018715 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1064539018716 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064539018717 N-terminal plug; other site 1064539018718 ligand-binding site [chemical binding]; other site 1064539018719 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1064539018720 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1064539018721 intersubunit interface [polypeptide binding]; other site 1064539018722 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1064539018723 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1064539018724 dimer interface [polypeptide binding]; other site 1064539018725 putative PBP binding regions; other site 1064539018726 ABC-ATPase subunit interface; other site 1064539018727 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064539018728 ABC-ATPase subunit interface; other site 1064539018729 dimer interface [polypeptide binding]; other site 1064539018730 putative PBP binding regions; other site 1064539018731 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1064539018732 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1064539018733 FAD binding pocket [chemical binding]; other site 1064539018734 FAD binding motif [chemical binding]; other site 1064539018735 phosphate binding motif [ion binding]; other site 1064539018736 NAD binding pocket [chemical binding]; other site 1064539018737 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1064539018738 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1064539018739 Walker A/P-loop; other site 1064539018740 ATP binding site [chemical binding]; other site 1064539018741 Q-loop/lid; other site 1064539018742 ABC transporter signature motif; other site 1064539018743 Walker B; other site 1064539018744 D-loop; other site 1064539018745 H-loop/switch region; other site 1064539018746 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1064539018747 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539018748 DNA binding residues [nucleotide binding] 1064539018749 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1064539018750 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1064539018751 active site 1064539018752 nucleophile elbow; other site 1064539018753 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1064539018754 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1064539018755 active site 1064539018756 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064539018757 dimer interface [polypeptide binding]; other site 1064539018758 substrate binding site [chemical binding]; other site 1064539018759 catalytic residues [active] 1064539018760 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539018761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064539018762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1064539018763 Cache domain; Region: Cache_1; pfam02743 1064539018764 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1064539018765 dimerization interface [polypeptide binding]; other site 1064539018766 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1064539018767 cyclase homology domain; Region: CHD; cd07302 1064539018768 nucleotidyl binding site; other site 1064539018769 metal binding site [ion binding]; metal-binding site 1064539018770 dimer interface [polypeptide binding]; other site 1064539018771 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539018772 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1064539018773 Helix-turn-helix domain; Region: HTH_36; pfam13730 1064539018774 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064539018775 MarR family; Region: MarR; pfam01047 1064539018776 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1064539018777 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1064539018778 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1064539018779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539018780 active site 1064539018781 phosphorylation site [posttranslational modification] 1064539018782 intermolecular recognition site; other site 1064539018783 dimerization interface [polypeptide binding]; other site 1064539018784 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064539018785 Zn2+ binding site [ion binding]; other site 1064539018786 Mg2+ binding site [ion binding]; other site 1064539018787 PAS fold; Region: PAS_4; pfam08448 1064539018788 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1064539018789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539018790 putative active site [active] 1064539018791 heme pocket [chemical binding]; other site 1064539018792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539018793 dimer interface [polypeptide binding]; other site 1064539018794 phosphorylation site [posttranslational modification] 1064539018795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539018796 ATP binding site [chemical binding]; other site 1064539018797 Mg2+ binding site [ion binding]; other site 1064539018798 G-X-G motif; other site 1064539018799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539018800 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539018801 active site 1064539018802 phosphorylation site [posttranslational modification] 1064539018803 intermolecular recognition site; other site 1064539018804 dimerization interface [polypeptide binding]; other site 1064539018805 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064539018806 putative binding surface; other site 1064539018807 active site 1064539018808 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1064539018809 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1064539018810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539018811 dimer interface [polypeptide binding]; other site 1064539018812 conserved gate region; other site 1064539018813 putative PBP binding loops; other site 1064539018814 ABC-ATPase subunit interface; other site 1064539018815 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1064539018816 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1064539018817 Walker A/P-loop; other site 1064539018818 ATP binding site [chemical binding]; other site 1064539018819 Q-loop/lid; other site 1064539018820 ABC transporter signature motif; other site 1064539018821 Walker B; other site 1064539018822 D-loop; other site 1064539018823 H-loop/switch region; other site 1064539018824 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1064539018825 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1064539018826 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1064539018827 active site 1064539018828 Zn binding site [ion binding]; other site 1064539018829 HutD; Region: HutD; pfam05962 1064539018830 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1064539018831 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1064539018832 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064539018833 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064539018834 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539018835 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1064539018836 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1064539018837 active site 1064539018838 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1064539018839 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539018840 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064539018841 substrate binding pocket [chemical binding]; other site 1064539018842 membrane-bound complex binding site; other site 1064539018843 hinge residues; other site 1064539018844 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064539018845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539018846 dimer interface [polypeptide binding]; other site 1064539018847 conserved gate region; other site 1064539018848 putative PBP binding loops; other site 1064539018849 ABC-ATPase subunit interface; other site 1064539018850 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1064539018851 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064539018852 Walker A/P-loop; other site 1064539018853 ATP binding site [chemical binding]; other site 1064539018854 Q-loop/lid; other site 1064539018855 ABC transporter signature motif; other site 1064539018856 Walker B; other site 1064539018857 D-loop; other site 1064539018858 H-loop/switch region; other site 1064539018859 AAA domain; Region: AAA_30; pfam13604 1064539018860 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 1064539018861 Family description; Region: UvrD_C_2; pfam13538 1064539018862 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1064539018863 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064539018864 molybdopterin cofactor binding site; other site 1064539018865 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 1064539018866 putative molybdopterin cofactor binding site [chemical binding]; other site 1064539018867 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1064539018868 putative molybdopterin cofactor binding site; other site 1064539018869 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1064539018870 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1064539018871 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1064539018872 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1064539018873 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1064539018874 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064539018875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539018876 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064539018877 dimerization interface [polypeptide binding]; other site 1064539018878 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064539018879 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064539018880 active site 1064539018881 catalytic tetrad [active] 1064539018882 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1064539018883 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539018884 dimerization interface [polypeptide binding]; other site 1064539018885 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1064539018886 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 1064539018887 HPP family; Region: HPP; pfam04982 1064539018888 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1064539018889 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1064539018890 ParB-like nuclease domain; Region: ParBc; pfam02195 1064539018891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1064539018892 non-specific DNA binding site [nucleotide binding]; other site 1064539018893 salt bridge; other site 1064539018894 sequence-specific DNA binding site [nucleotide binding]; other site 1064539018895 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539018896 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1064539018897 P-loop; other site 1064539018898 Magnesium ion binding site [ion binding]; other site 1064539018899 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539018900 Magnesium ion binding site [ion binding]; other site 1064539018901 Peptidase family M48; Region: Peptidase_M48; pfam01435 1064539018902 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1064539018903 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1064539018904 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1064539018905 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1064539018906 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1064539018907 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1064539018908 Predicted permeases [General function prediction only]; Region: COG0679 1064539018909 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1064539018910 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1064539018911 active site 1064539018912 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1064539018913 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1064539018914 active site 1064539018915 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1064539018916 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1064539018917 O-Antigen ligase; Region: Wzy_C; pfam04932 1064539018918 Chain length determinant protein; Region: Wzz; cl15801 1064539018919 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 1064539018920 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1064539018921 Nucleotide binding site [chemical binding]; other site 1064539018922 P loop; other site 1064539018923 DTAP/Switch II; other site 1064539018924 Switch I; other site 1064539018925 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1064539018926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539018927 NAD(P) binding site [chemical binding]; other site 1064539018928 active site 1064539018929 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1064539018930 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1064539018931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1064539018932 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539018933 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539018934 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1064539018935 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1064539018936 putative active site [active] 1064539018937 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064539018938 active site 1064539018939 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1064539018940 Right handed beta helix region; Region: Beta_helix; pfam13229 1064539018941 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1064539018942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064539018943 putative DNA binding site [nucleotide binding]; other site 1064539018944 putative Zn2+ binding site [ion binding]; other site 1064539018945 AsnC family; Region: AsnC_trans_reg; pfam01037 1064539018946 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1064539018947 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1064539018948 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 1064539018949 Proline dehydrogenase; Region: Pro_dh; pfam01619 1064539018950 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1064539018951 Glutamate binding site [chemical binding]; other site 1064539018952 NAD binding site [chemical binding]; other site 1064539018953 catalytic residues [active] 1064539018954 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1064539018955 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1064539018956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064539018957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064539018958 DNA binding residues [nucleotide binding] 1064539018959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064539018960 dimerization interface [polypeptide binding]; other site 1064539018961 putative DNA binding site [nucleotide binding]; other site 1064539018962 putative Zn2+ binding site [ion binding]; other site 1064539018963 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1064539018964 active site residue [active] 1064539018965 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1064539018966 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539018967 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539018968 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539018969 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1064539018970 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1064539018971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539018972 dimer interface [polypeptide binding]; other site 1064539018973 phosphorylation site [posttranslational modification] 1064539018974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539018975 ATP binding site [chemical binding]; other site 1064539018976 Mg2+ binding site [ion binding]; other site 1064539018977 G-X-G motif; other site 1064539018978 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1064539018979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539018980 active site 1064539018981 phosphorylation site [posttranslational modification] 1064539018982 intermolecular recognition site; other site 1064539018983 dimerization interface [polypeptide binding]; other site 1064539018984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539018985 DNA binding residues [nucleotide binding] 1064539018986 dimerization interface [polypeptide binding]; other site 1064539018987 thioredoxin 2; Provisional; Region: PRK10996 1064539018988 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1064539018989 catalytic residues [active] 1064539018990 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 1064539018991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539018992 NAD(P) binding site [chemical binding]; other site 1064539018993 active site 1064539018994 potential frameshift: common BLAST hit: gi|374293929|ref|YP_005040952.1| para-aminobenzoate synthase, subunit I 1064539018995 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1064539018996 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1064539018997 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1064539018998 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1064539018999 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1064539019000 homodimer interface [polypeptide binding]; other site 1064539019001 substrate-cofactor binding pocket; other site 1064539019002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539019003 catalytic residue [active] 1064539019004 DsrE/DsrF-like family; Region: DrsE; pfam02635 1064539019005 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1064539019006 Peptidase family M50; Region: Peptidase_M50; pfam02163 1064539019007 active site 1064539019008 putative substrate binding region [chemical binding]; other site 1064539019009 FOG: CBS domain [General function prediction only]; Region: COG0517 1064539019010 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_26; cd04639 1064539019011 potential frameshift: common BLAST hit: gi|374998026|ref|YP_004973525.1| putative transketolase 1064539019012 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1064539019013 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1064539019014 PYR/PP interface [polypeptide binding]; other site 1064539019015 dimer interface [polypeptide binding]; other site 1064539019016 TPP binding site [chemical binding]; other site 1064539019017 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1064539019018 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1064539019019 TPP-binding site [chemical binding]; other site 1064539019020 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1064539019021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064539019022 putative DNA binding site [nucleotide binding]; other site 1064539019023 putative Zn2+ binding site [ion binding]; other site 1064539019024 AsnC family; Region: AsnC_trans_reg; pfam01037 1064539019025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539019026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539019027 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1064539019028 putative effector binding pocket; other site 1064539019029 dimerization interface [polypeptide binding]; other site 1064539019030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539019031 D-galactonate transporter; Region: 2A0114; TIGR00893 1064539019032 putative substrate translocation pore; other site 1064539019033 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064539019034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539019035 DNA-binding site [nucleotide binding]; DNA binding site 1064539019036 FCD domain; Region: FCD; pfam07729 1064539019037 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539019038 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539019039 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1064539019040 DctM-like transporters; Region: DctM; pfam06808 1064539019041 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1064539019042 Protein of unknown function (DUF808); Region: DUF808; cl01002 1064539019043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539019044 non-specific DNA binding site [nucleotide binding]; other site 1064539019045 salt bridge; other site 1064539019046 sequence-specific DNA binding site [nucleotide binding]; other site 1064539019047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539019048 TPR motif; other site 1064539019049 binding surface 1064539019050 TPR repeat; Region: TPR_11; pfam13414 1064539019051 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1064539019052 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1064539019053 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064539019054 Zn2+ binding site [ion binding]; other site 1064539019055 Mg2+ binding site [ion binding]; other site 1064539019056 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1064539019057 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1064539019058 Walker A/P-loop; other site 1064539019059 ATP binding site [chemical binding]; other site 1064539019060 Q-loop/lid; other site 1064539019061 ABC transporter signature motif; other site 1064539019062 Walker B; other site 1064539019063 D-loop; other site 1064539019064 H-loop/switch region; other site 1064539019065 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1064539019066 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064539019067 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1064539019068 Amidase; Region: Amidase; cl11426 1064539019069 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1064539019070 Amidase; Region: Amidase; pfam01425 1064539019071 Isochorismatase family; Region: Isochorismatase; pfam00857 1064539019072 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1064539019073 catalytic triad [active] 1064539019074 conserved cis-peptide bond; other site 1064539019075 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064539019076 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1064539019077 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539019078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019079 dimer interface [polypeptide binding]; other site 1064539019080 conserved gate region; other site 1064539019081 putative PBP binding loops; other site 1064539019082 ABC-ATPase subunit interface; other site 1064539019083 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1064539019084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019085 dimer interface [polypeptide binding]; other site 1064539019086 conserved gate region; other site 1064539019087 putative PBP binding loops; other site 1064539019088 ABC-ATPase subunit interface; other site 1064539019089 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1064539019090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539019091 Walker A/P-loop; other site 1064539019092 ATP binding site [chemical binding]; other site 1064539019093 Q-loop/lid; other site 1064539019094 ABC transporter signature motif; other site 1064539019095 Walker B; other site 1064539019096 D-loop; other site 1064539019097 H-loop/switch region; other site 1064539019098 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539019099 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1064539019100 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064539019101 Walker A/P-loop; other site 1064539019102 ATP binding site [chemical binding]; other site 1064539019103 Q-loop/lid; other site 1064539019104 ABC transporter signature motif; other site 1064539019105 Walker B; other site 1064539019106 D-loop; other site 1064539019107 H-loop/switch region; other site 1064539019108 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064539019109 Isochorismatase family; Region: Isochorismatase; pfam00857 1064539019110 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1064539019111 catalytic triad [active] 1064539019112 conserved cis-peptide bond; other site 1064539019113 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1064539019114 potential frameshift: common BLAST hit: gi|288961688|ref|YP_003451998.1| ammonia monooxygenase 1064539019115 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1064539019116 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064539019117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539019118 DNA-binding site [nucleotide binding]; DNA binding site 1064539019119 FCD domain; Region: FCD; pfam07729 1064539019120 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1064539019121 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1064539019122 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1064539019123 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1064539019124 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 1064539019125 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1064539019126 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1064539019127 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1064539019128 Ligand Binding Site [chemical binding]; other site 1064539019129 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1064539019130 GAF domain; Region: GAF_3; pfam13492 1064539019131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539019132 dimer interface [polypeptide binding]; other site 1064539019133 phosphorylation site [posttranslational modification] 1064539019134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539019135 ATP binding site [chemical binding]; other site 1064539019136 Mg2+ binding site [ion binding]; other site 1064539019137 G-X-G motif; other site 1064539019138 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1064539019139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539019140 active site 1064539019141 phosphorylation site [posttranslational modification] 1064539019142 intermolecular recognition site; other site 1064539019143 dimerization interface [polypeptide binding]; other site 1064539019144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064539019145 DNA binding site [nucleotide binding] 1064539019146 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1064539019147 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1064539019148 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064539019149 catalytic loop [active] 1064539019150 iron binding site [ion binding]; other site 1064539019151 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1064539019152 cyclase homology domain; Region: CHD; cd07302 1064539019153 nucleotidyl binding site; other site 1064539019154 metal binding site [ion binding]; metal-binding site 1064539019155 dimer interface [polypeptide binding]; other site 1064539019156 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064539019157 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539019158 ligand binding site [chemical binding]; other site 1064539019159 flexible hinge region; other site 1064539019160 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1064539019161 putative switch regulator; other site 1064539019162 non-specific DNA interactions [nucleotide binding]; other site 1064539019163 DNA binding site [nucleotide binding] 1064539019164 sequence specific DNA binding site [nucleotide binding]; other site 1064539019165 putative cAMP binding site [chemical binding]; other site 1064539019166 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1064539019167 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1064539019168 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1064539019169 putative FMN binding site [chemical binding]; other site 1064539019170 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539019171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539019172 active site 1064539019173 phosphorylation site [posttranslational modification] 1064539019174 intermolecular recognition site; other site 1064539019175 dimerization interface [polypeptide binding]; other site 1064539019176 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1064539019177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539019178 active site 1064539019179 phosphorylation site [posttranslational modification] 1064539019180 intermolecular recognition site; other site 1064539019181 dimerization interface [polypeptide binding]; other site 1064539019182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539019183 DNA binding residues [nucleotide binding] 1064539019184 dimerization interface [polypeptide binding]; other site 1064539019185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539019186 PAS domain; Region: PAS_9; pfam13426 1064539019187 putative active site [active] 1064539019188 heme pocket [chemical binding]; other site 1064539019189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539019190 putative active site [active] 1064539019191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539019192 heme pocket [chemical binding]; other site 1064539019193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539019194 dimer interface [polypeptide binding]; other site 1064539019195 phosphorylation site [posttranslational modification] 1064539019196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539019197 ATP binding site [chemical binding]; other site 1064539019198 Mg2+ binding site [ion binding]; other site 1064539019199 G-X-G motif; other site 1064539019200 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1064539019201 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1064539019202 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1064539019203 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1064539019204 Protein export membrane protein; Region: SecD_SecF; cl14618 1064539019205 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12107133; Product type t : transporter 1064539019206 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12107133; Product type t : transporter 1064539019207 Protein of unknown function (DUF3624); Region: DUF3624; pfam12292 1064539019208 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1064539019209 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539019210 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539019211 aspartate aminotransferase; Provisional; Region: PRK05764 1064539019212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064539019213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064539019214 homodimer interface [polypeptide binding]; other site 1064539019215 catalytic residue [active] 1064539019216 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1064539019217 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1064539019218 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1064539019219 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1064539019220 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539019221 dimerization interface [polypeptide binding]; other site 1064539019222 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1064539019223 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539019224 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539019225 dimer interface [polypeptide binding]; other site 1064539019226 putative CheW interface [polypeptide binding]; other site 1064539019227 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1064539019228 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1064539019229 acyl-activating enzyme (AAE) consensus motif; other site 1064539019230 putative AMP binding site [chemical binding]; other site 1064539019231 putative active site [active] 1064539019232 putative CoA binding site [chemical binding]; other site 1064539019233 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1064539019234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019235 dimer interface [polypeptide binding]; other site 1064539019236 conserved gate region; other site 1064539019237 putative PBP binding loops; other site 1064539019238 ABC-ATPase subunit interface; other site 1064539019239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019240 dimer interface [polypeptide binding]; other site 1064539019241 conserved gate region; other site 1064539019242 putative PBP binding loops; other site 1064539019243 ABC-ATPase subunit interface; other site 1064539019244 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1064539019245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539019246 Walker A/P-loop; other site 1064539019247 ATP binding site [chemical binding]; other site 1064539019248 Q-loop/lid; other site 1064539019249 ABC transporter signature motif; other site 1064539019250 Walker B; other site 1064539019251 D-loop; other site 1064539019252 H-loop/switch region; other site 1064539019253 TOBE domain; Region: TOBE_2; pfam08402 1064539019254 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1064539019255 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539019256 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1064539019257 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539019258 substrate binding site [chemical binding]; other site 1064539019259 oxyanion hole (OAH) forming residues; other site 1064539019260 trimer interface [polypeptide binding]; other site 1064539019261 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064539019262 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064539019263 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539019264 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 1064539019265 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1064539019266 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1064539019267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539019268 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1064539019269 Walker A/P-loop; other site 1064539019270 ATP binding site [chemical binding]; other site 1064539019271 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1064539019272 AAA domain; Region: AAA_12; pfam13087 1064539019273 potential frameshift: common BLAST hit: gi|148243790|ref|YP_001220030.1| RecD/TraA family helicase 1064539019274 AAA domain; Region: AAA_30; pfam13604 1064539019275 potential frameshift: common BLAST hit: gi|148243790|ref|YP_001220030.1| RecD/TraA family helicase 1064539019276 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1064539019277 potential frameshift: common BLAST hit: gi|339328455|ref|YP_004688147.1| endocuclease TsnA domain-containing protein 1064539019278 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1064539019279 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1064539019280 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539019281 Moco binding site; other site 1064539019282 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1064539019283 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539019284 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1064539019285 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1064539019286 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1064539019287 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1064539019288 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539019289 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1064539019290 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539019291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539019292 active site 1064539019293 phosphorylation site [posttranslational modification] 1064539019294 intermolecular recognition site; other site 1064539019295 dimerization interface [polypeptide binding]; other site 1064539019296 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1064539019297 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1064539019298 dimer interface [polypeptide binding]; other site 1064539019299 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064539019300 ligand binding site [chemical binding]; other site 1064539019301 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1064539019302 Kelch domain; Region: Kelch; smart00612 1064539019303 Kelch motif; Region: Kelch_6; pfam13964 1064539019304 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1064539019305 Dihydroneopterin aldolase; Region: FolB; pfam02152 1064539019306 active site 1064539019307 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1064539019308 FAD binding site [chemical binding]; other site 1064539019309 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1064539019310 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1064539019311 active site 1064539019312 substrate binding site [chemical binding]; other site 1064539019313 coenzyme B12 binding site [chemical binding]; other site 1064539019314 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1064539019315 B12 binding site [chemical binding]; other site 1064539019316 cobalt ligand [ion binding]; other site 1064539019317 potential frameshift: common BLAST hit: gi|83593815|ref|YP_427567.1| methylmalonyl-CoA mutase 1064539019318 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1064539019319 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1064539019320 heterodimer interface [polypeptide binding]; other site 1064539019321 substrate interaction site [chemical binding]; other site 1064539019322 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1064539019323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539019324 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1064539019325 putative dimerization interface [polypeptide binding]; other site 1064539019326 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1064539019327 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1064539019328 THF binding site; other site 1064539019329 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1064539019330 substrate binding site [chemical binding]; other site 1064539019331 THF binding site; other site 1064539019332 zinc-binding site [ion binding]; other site 1064539019333 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539019334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539019335 non-specific DNA binding site [nucleotide binding]; other site 1064539019336 salt bridge; other site 1064539019337 sequence-specific DNA binding site [nucleotide binding]; other site 1064539019338 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1064539019339 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1064539019340 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1064539019341 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 1064539019342 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1064539019343 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1064539019344 active site 1064539019345 dimer interface [polypeptide binding]; other site 1064539019346 catalytic residues [active] 1064539019347 effector binding site; other site 1064539019348 R2 peptide binding site; other site 1064539019349 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1064539019350 dimer interface [polypeptide binding]; other site 1064539019351 putative radical transfer pathway; other site 1064539019352 diiron center [ion binding]; other site 1064539019353 tyrosyl radical; other site 1064539019354 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1064539019355 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1064539019356 dimer interface [polypeptide binding]; other site 1064539019357 active site 1064539019358 citrylCoA binding site [chemical binding]; other site 1064539019359 oxalacetate/citrate binding site [chemical binding]; other site 1064539019360 coenzyme A binding site [chemical binding]; other site 1064539019361 catalytic triad [active] 1064539019362 potential frameshift: common BLAST hit: gi|226944413|ref|YP_002799486.1| aconitate hydratase 1064539019363 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1064539019364 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1064539019365 aconitate hydratase; Validated; Region: PRK09277 1064539019366 substrate binding site [chemical binding]; other site 1064539019367 ligand binding site [chemical binding]; other site 1064539019368 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1064539019369 substrate binding site [chemical binding]; other site 1064539019370 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1064539019371 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1064539019372 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1064539019373 tetramer interface [polypeptide binding]; other site 1064539019374 active site 1064539019375 Mg2+/Mn2+ binding site [ion binding]; other site 1064539019376 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1064539019377 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type rc : receptor 1064539019378 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type rc : receptor 1064539019379 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1064539019380 Sulfatase; Region: Sulfatase; pfam00884 1064539019381 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1064539019382 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1064539019383 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1064539019384 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1064539019385 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1064539019386 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1064539019387 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1064539019388 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1064539019389 MoxR-like ATPases [General function prediction only]; Region: COG0714 1064539019390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539019391 Walker A motif; other site 1064539019392 ATP binding site [chemical binding]; other site 1064539019393 Walker B motif; other site 1064539019394 arginine finger; other site 1064539019395 Protein of unknown function DUF58; Region: DUF58; pfam01882 1064539019396 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1064539019397 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1064539019398 metal ion-dependent adhesion site (MIDAS); other site 1064539019399 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1064539019400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539019401 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539019402 TPR motif; other site 1064539019403 binding surface 1064539019404 Oxygen tolerance; Region: BatD; pfam13584 1064539019405 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539019406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539019407 dimerization interface [polypeptide binding]; other site 1064539019408 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539019409 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539019410 dimer interface [polypeptide binding]; other site 1064539019411 putative CheW interface [polypeptide binding]; other site 1064539019412 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539019413 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539019414 dimer interface [polypeptide binding]; other site 1064539019415 putative CheW interface [polypeptide binding]; other site 1064539019416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539019417 PAS fold; Region: PAS_3; pfam08447 1064539019418 putative active site [active] 1064539019419 heme pocket [chemical binding]; other site 1064539019420 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539019421 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539019422 dimer interface [polypeptide binding]; other site 1064539019423 putative CheW interface [polypeptide binding]; other site 1064539019424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539019425 putative active site [active] 1064539019426 heme pocket [chemical binding]; other site 1064539019427 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064539019428 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064539019429 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1064539019430 active site 1064539019431 Int/Topo IB signature motif; other site 1064539019432 DNA binding site [nucleotide binding] 1064539019433 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1064539019434 MULE transposase domain; Region: MULE; pfam10551 1064539019435 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539019436 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1064539019437 Cadherin repeat-like domain; Region: CA_like; cl15786 1064539019438 Ca2+ binding site [ion binding]; other site 1064539019439 Calx-beta domain; Region: Calx-beta; cl02522 1064539019440 Calx-beta domain; Region: Calx-beta; cl02522 1064539019441 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539019442 RibD C-terminal domain; Region: RibD_C; cl17279 1064539019443 PqqA family; Region: PqqA; cl15372 1064539019444 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1064539019445 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1064539019446 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064539019447 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 1064539019448 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 1064539019449 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1064539019450 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 1064539019451 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 1064539019452 active site 1064539019453 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 1064539019454 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 1064539019455 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1064539019456 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 1064539019457 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 1064539019458 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 1064539019459 trimer interface I [polypeptide binding]; other site 1064539019460 putative substrate binding pocket [chemical binding]; other site 1064539019461 trimer interface II [polypeptide binding]; other site 1064539019462 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 1064539019463 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1064539019464 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 1064539019465 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1064539019466 NAD(P) binding pocket [chemical binding]; other site 1064539019467 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1064539019468 aromatic arch; other site 1064539019469 DCoH dimer interaction site [polypeptide binding]; other site 1064539019470 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1064539019471 DCoH tetramer interaction site [polypeptide binding]; other site 1064539019472 substrate binding site [chemical binding]; other site 1064539019473 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064539019474 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 1064539019475 molybdopterin cofactor binding site; other site 1064539019476 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 1064539019477 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1064539019478 active site 1064539019479 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 1064539019480 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 1064539019481 FTR, proximal lobe; Region: FTR_C; pfam02741 1064539019482 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1064539019483 domain_subunit interface; other site 1064539019484 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1064539019485 ligand binding site [chemical binding]; other site 1064539019486 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539019487 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1064539019488 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1064539019489 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1064539019490 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1064539019491 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1064539019492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539019493 Walker A/P-loop; other site 1064539019494 ATP binding site [chemical binding]; other site 1064539019495 Q-loop/lid; other site 1064539019496 ABC transporter signature motif; other site 1064539019497 Walker B; other site 1064539019498 D-loop; other site 1064539019499 H-loop/switch region; other site 1064539019500 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1064539019501 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064539019502 hypothetical protein; Provisional; Region: PRK02227 1064539019503 Protein of unknown function (DUF447); Region: DUF447; pfam04289 1064539019504 dihydropteroate synthase-related protein; Region: TIGR00284 1064539019505 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1064539019506 substrate binding pocket [chemical binding]; other site 1064539019507 dimer interface [polypeptide binding]; other site 1064539019508 inhibitor binding site; inhibition site 1064539019509 AAK_UC: Uncharacterized (UC) amino acid kinase-like proteins found mainly in archaea and a few bacteria. Sequences in this CD are members of the Amino Acid Kinase (AAK) superfamily; Region: AAK_UC; cd04240 1064539019510 putative nucleotide binding site [chemical binding]; other site 1064539019511 putative substrate binding site [chemical binding]; other site 1064539019512 Dihydroneopterin aldolase; Region: FolB; smart00905 1064539019513 active site 1064539019514 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 1064539019515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539019516 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 1064539019517 substrate binding pocket [chemical binding]; other site 1064539019518 membrane-bound complex binding site; other site 1064539019519 hinge residues; other site 1064539019520 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1064539019521 active site residue [active] 1064539019522 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 1064539019523 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1064539019524 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1064539019525 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 1064539019526 Trp docking motif [polypeptide binding]; other site 1064539019527 dimer interface [polypeptide binding]; other site 1064539019528 active site 1064539019529 small subunit binding site [polypeptide binding]; other site 1064539019530 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 1064539019531 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1064539019532 Fe-S cluster binding site [ion binding]; other site 1064539019533 active site 1064539019534 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 1064539019535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539019536 FeS/SAM binding site; other site 1064539019537 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1064539019538 Beta-lactamase; Region: Beta-lactamase; pfam00144 1064539019539 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1064539019540 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1064539019541 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1064539019542 active site 1064539019543 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 1064539019544 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 1064539019545 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1064539019546 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064539019547 thiolase; Provisional; Region: PRK06158 1064539019548 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1064539019549 active site 1064539019550 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1064539019551 DUF35 OB-fold domain; Region: DUF35; pfam01796 1064539019552 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1064539019553 active site 2 [active] 1064539019554 active site 1 [active] 1064539019555 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1064539019556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539019557 NAD(P) binding site [chemical binding]; other site 1064539019558 active site 1064539019559 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1064539019560 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064539019561 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1064539019562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019563 dimer interface [polypeptide binding]; other site 1064539019564 conserved gate region; other site 1064539019565 putative PBP binding loops; other site 1064539019566 ABC-ATPase subunit interface; other site 1064539019567 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1064539019568 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1064539019569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539019570 Walker A/P-loop; other site 1064539019571 ATP binding site [chemical binding]; other site 1064539019572 Q-loop/lid; other site 1064539019573 ABC transporter signature motif; other site 1064539019574 Walker B; other site 1064539019575 D-loop; other site 1064539019576 H-loop/switch region; other site 1064539019577 TOBE domain; Region: TOBE_2; pfam08402 1064539019578 enoyl-CoA hydratase; Provisional; Region: PRK06144 1064539019579 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064539019580 substrate binding site [chemical binding]; other site 1064539019581 oxyanion hole (OAH) forming residues; other site 1064539019582 trimer interface [polypeptide binding]; other site 1064539019583 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1064539019584 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539019585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539019586 TPR motif; other site 1064539019587 binding surface 1064539019588 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064539019589 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 1064539019590 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1064539019591 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1064539019592 acyl carrier protein; Provisional; Region: PRK07081 1064539019593 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064539019594 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064539019595 active site 1064539019596 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064539019597 active site 1064539019598 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 1064539019599 dimer interface [polypeptide binding]; other site 1064539019600 motif 1; other site 1064539019601 active site 1064539019602 motif 2; other site 1064539019603 motif 3; other site 1064539019604 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 1064539019605 potential frameshift: common BLAST hit: gi|288962744|ref|YP_003453038.1| beta-mannosidase 1064539019606 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1064539019607 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1064539019608 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1064539019609 Phage Tail Collar Domain; Region: Collar; pfam07484 1064539019610 Phage Tail Collar Domain; Region: Collar; pfam07484 1064539019611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064539019612 Coenzyme A binding pocket [chemical binding]; other site 1064539019613 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 1064539019614 middle domain of the stomatal closure-related actin binding protein1; Region: SCAB1_middle; cd11675 1064539019615 PH domain interface [polypeptide binding]; other site 1064539019616 middle domain of the stomatal closure-related actin binding protein1; Region: SCAB1_middle; cd11675 1064539019617 PH domain interface [polypeptide binding]; other site 1064539019618 middle domain of the stomatal closure-related actin binding protein1; Region: SCAB1_middle; cd11675 1064539019619 PH domain interface [polypeptide binding]; other site 1064539019620 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1064539019621 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064539019622 Outer membrane efflux protein; Region: OEP; pfam02321 1064539019623 Outer membrane efflux protein; Region: OEP; pfam02321 1064539019624 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539019625 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539019626 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539019627 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539019628 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1064539019629 active site 1064539019630 putative substrate binding region [chemical binding]; other site 1064539019631 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1064539019632 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539019633 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1064539019634 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064539019635 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 1064539019636 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1064539019637 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1064539019638 GAF domain; Region: GAF; pfam01590 1064539019639 PAS domain S-box; Region: sensory_box; TIGR00229 1064539019640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539019641 putative active site [active] 1064539019642 heme pocket [chemical binding]; other site 1064539019643 PAS domain S-box; Region: sensory_box; TIGR00229 1064539019644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539019645 putative active site [active] 1064539019646 heme pocket [chemical binding]; other site 1064539019647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539019648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539019649 dimer interface [polypeptide binding]; other site 1064539019650 phosphorylation site [posttranslational modification] 1064539019651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539019652 ATP binding site [chemical binding]; other site 1064539019653 Mg2+ binding site [ion binding]; other site 1064539019654 G-X-G motif; other site 1064539019655 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064539019656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539019657 active site 1064539019658 phosphorylation site [posttranslational modification] 1064539019659 intermolecular recognition site; other site 1064539019660 dimerization interface [polypeptide binding]; other site 1064539019661 PBP superfamily domain; Region: PBP_like_2; cl17296 1064539019662 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1064539019663 apolar tunnel; other site 1064539019664 heme binding site [chemical binding]; other site 1064539019665 dimerization interface [polypeptide binding]; other site 1064539019666 Helix-turn-helix domain; Region: HTH_36; pfam13730 1064539019667 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 1064539019668 GIY-YIG motif/motif A; other site 1064539019669 putative active site [active] 1064539019670 putative metal binding site [ion binding]; other site 1064539019671 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1064539019672 citrylCoA binding site [chemical binding]; other site 1064539019673 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1064539019674 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1064539019675 catalytic residues [active] 1064539019676 catalytic nucleophile [active] 1064539019677 Recombinase; Region: Recombinase; pfam07508 1064539019678 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1064539019679 large terminase protein; Provisional; Region: 17; PHA02533 1064539019680 Terminase-like family; Region: Terminase_6; pfam03237 1064539019681 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 1064539019682 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1064539019683 Mu-like prophage protein [General function prediction only]; Region: COG3941 1064539019684 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1064539019685 Phage minor tail protein; Region: Phage_min_tail; cl01940 1064539019686 Phage minor tail protein L; Region: Phage_tail_L; cl01908 1064539019687 VPS10 domain; Region: VPS10; smart00602 1064539019688 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1064539019689 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1064539019690 active site 1064539019691 catalytic residues [active] 1064539019692 DNA binding site [nucleotide binding] 1064539019693 Int/Topo IB signature motif; other site 1064539019694 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1064539019695 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1064539019696 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1064539019697 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1064539019698 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1064539019699 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1064539019700 Cysteine-rich domain; Region: CCG; pfam02754 1064539019701 Cysteine-rich domain; Region: CCG; pfam02754 1064539019702 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1064539019703 FAD binding domain; Region: FAD_binding_4; pfam01565 1064539019704 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1064539019705 L-lactate permease; Provisional; Region: PRK10420 1064539019706 glycolate transporter; Provisional; Region: PRK09695 1064539019707 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1064539019708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064539019709 DNA-binding site [nucleotide binding]; DNA binding site 1064539019710 FCD domain; Region: FCD; pfam07729 1064539019711 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1064539019712 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1064539019713 active site 1064539019714 oxyanion hole [active] 1064539019715 catalytic triad [active] 1064539019716 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1064539019717 oxyanion hole [active] 1064539019718 OpgC protein; Region: OpgC_C; pfam10129 1064539019719 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1064539019720 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1064539019721 putative [4Fe-4S] binding site [ion binding]; other site 1064539019722 putative molybdopterin cofactor binding site [chemical binding]; other site 1064539019723 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1064539019724 putative molybdopterin cofactor binding site; other site 1064539019725 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539019726 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539019727 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539019728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539019729 ABC transporter signature motif; other site 1064539019730 Walker B; other site 1064539019731 D-loop; other site 1064539019732 H-loop/switch region; other site 1064539019733 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1064539019734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539019735 Walker A/P-loop; other site 1064539019736 ATP binding site [chemical binding]; other site 1064539019737 Q-loop/lid; other site 1064539019738 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539019739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019740 dimer interface [polypeptide binding]; other site 1064539019741 conserved gate region; other site 1064539019742 putative PBP binding loops; other site 1064539019743 ABC-ATPase subunit interface; other site 1064539019744 NMT1/THI5 like; Region: NMT1; pfam09084 1064539019745 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539019746 substrate binding pocket [chemical binding]; other site 1064539019747 membrane-bound complex binding site; other site 1064539019748 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1064539019749 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1064539019750 substrate binding pocket [chemical binding]; other site 1064539019751 active site 1064539019752 iron coordination sites [ion binding]; other site 1064539019753 choline-sulfatase; Region: chol_sulfatase; TIGR03417 1064539019754 Sulfatase; Region: Sulfatase; cl17466 1064539019755 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 1064539019756 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539019757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019758 ABC-ATPase subunit interface; other site 1064539019759 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter 1064539019760 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1064539019761 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064539019762 substrate binding pocket [chemical binding]; other site 1064539019763 membrane-bound complex binding site; other site 1064539019764 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1064539019765 putative FMN binding site [chemical binding]; other site 1064539019766 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1064539019767 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1064539019768 active site 1064539019769 iron coordination sites [ion binding]; other site 1064539019770 substrate binding pocket [chemical binding]; other site 1064539019771 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1064539019772 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1064539019773 membrane-bound complex binding site; other site 1064539019774 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1064539019775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019776 dimer interface [polypeptide binding]; other site 1064539019777 ABC-ATPase subunit interface; other site 1064539019778 putative PBP binding loops; other site 1064539019779 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter 1064539019780 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1064539019781 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1064539019782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1064539019783 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1064539019784 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1064539019785 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1064539019786 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1064539019787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1064539019788 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1064539019789 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1064539019790 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1064539019791 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1064539019792 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1064539019793 active site pocket [active] 1064539019794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064539019795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019796 dimer interface [polypeptide binding]; other site 1064539019797 conserved gate region; other site 1064539019798 ABC-ATPase subunit interface; other site 1064539019799 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1064539019800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019801 dimer interface [polypeptide binding]; other site 1064539019802 conserved gate region; other site 1064539019803 putative PBP binding loops; other site 1064539019804 ABC-ATPase subunit interface; other site 1064539019805 Evidence 2b : Function of strongly homologous gene; PubMedId : 7536291; Product type t : transporter 1064539019806 Evidence 2b : Function of strongly homologous gene; PubMedId : 7536291; Product type t : transporter 1064539019807 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064539019808 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1064539019809 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1064539019810 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1064539019811 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1064539019812 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1064539019813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539019814 non-specific DNA binding site [nucleotide binding]; other site 1064539019815 salt bridge; other site 1064539019816 sequence-specific DNA binding site [nucleotide binding]; other site 1064539019817 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1064539019818 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1064539019819 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064539019820 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064539019821 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064539019822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019823 putative PBP binding loops; other site 1064539019824 ABC-ATPase subunit interface; other site 1064539019825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019826 dimer interface [polypeptide binding]; other site 1064539019827 conserved gate region; other site 1064539019828 putative PBP binding loops; other site 1064539019829 ABC-ATPase subunit interface; other site 1064539019830 spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187 1064539019831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539019832 Walker A/P-loop; other site 1064539019833 ATP binding site [chemical binding]; other site 1064539019834 Q-loop/lid; other site 1064539019835 ABC transporter signature motif; other site 1064539019836 Walker B; other site 1064539019837 D-loop; other site 1064539019838 H-loop/switch region; other site 1064539019839 TOBE domain; Region: TOBE_2; pfam08402 1064539019840 potential frameshift: common BLAST hit: gi|221369399|ref|YP_002520495.1| Extracellular solute-binding protein, family 1 precursor 1064539019841 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1064539019842 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064539019843 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1064539019844 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1064539019845 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1064539019846 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1064539019847 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1064539019848 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1064539019849 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1064539019850 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1064539019851 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1064539019852 oligomerisation interface [polypeptide binding]; other site 1064539019853 mobile loop; other site 1064539019854 roof hairpin; other site 1064539019855 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1064539019856 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1064539019857 ring oligomerisation interface [polypeptide binding]; other site 1064539019858 ATP/Mg binding site [chemical binding]; other site 1064539019859 stacking interactions; other site 1064539019860 hinge regions; other site 1064539019861 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1064539019862 serine O-acetyltransferase; Region: cysE; TIGR01172 1064539019863 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1064539019864 trimer interface [polypeptide binding]; other site 1064539019865 active site 1064539019866 substrate binding site [chemical binding]; other site 1064539019867 CoA binding site [chemical binding]; other site 1064539019868 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1064539019869 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1064539019870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064539019871 catalytic residue [active] 1064539019872 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539019873 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539019874 non-specific DNA binding site [nucleotide binding]; other site 1064539019875 salt bridge; other site 1064539019876 sequence-specific DNA binding site [nucleotide binding]; other site 1064539019877 Cupin domain; Region: Cupin_2; pfam07883 1064539019878 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1064539019879 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1064539019880 tetramer interface [polypeptide binding]; other site 1064539019881 TPP-binding site [chemical binding]; other site 1064539019882 heterodimer interface [polypeptide binding]; other site 1064539019883 phosphorylation loop region [posttranslational modification] 1064539019884 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1064539019885 PYR/PP interface [polypeptide binding]; other site 1064539019886 dimer interface [polypeptide binding]; other site 1064539019887 TPP binding site [chemical binding]; other site 1064539019888 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064539019889 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064539019890 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064539019891 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1064539019892 DctM-like transporters; Region: DctM; pfam06808 1064539019893 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1064539019894 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1064539019895 classical (c) SDRs; Region: SDR_c; cd05233 1064539019896 NAD(P) binding site [chemical binding]; other site 1064539019897 active site 1064539019898 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1064539019899 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1064539019900 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1064539019901 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1064539019902 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1064539019903 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1064539019904 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1064539019905 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1064539019906 active site 1064539019907 dimer interface [polypeptide binding]; other site 1064539019908 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1064539019909 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7692961; Product type e : enzyme 1064539019910 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7692961; Product type e : enzyme 1064539019911 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 1064539019912 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 1064539019913 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064539019914 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064539019915 TM-ABC transporter signature motif; other site 1064539019916 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539019917 TM-ABC transporter signature motif; other site 1064539019918 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539019919 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539019920 Walker A/P-loop; other site 1064539019921 ATP binding site [chemical binding]; other site 1064539019922 Q-loop/lid; other site 1064539019923 ABC transporter signature motif; other site 1064539019924 Walker B; other site 1064539019925 D-loop; other site 1064539019926 H-loop/switch region; other site 1064539019927 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539019928 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539019929 Walker A/P-loop; other site 1064539019930 ATP binding site [chemical binding]; other site 1064539019931 Q-loop/lid; other site 1064539019932 ABC transporter signature motif; other site 1064539019933 Walker B; other site 1064539019934 D-loop; other site 1064539019935 H-loop/switch region; other site 1064539019936 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539019937 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1064539019938 ligand binding site [chemical binding]; other site 1064539019939 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1064539019940 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1064539019941 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1064539019942 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064539019943 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1064539019944 active site 1064539019945 catalytic triad [active] 1064539019946 oxyanion hole [active] 1064539019947 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1064539019948 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1064539019949 dimer interface [polypeptide binding]; other site 1064539019950 active site 1064539019951 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1064539019952 dimer interface [polypeptide binding]; other site 1064539019953 active site 1064539019954 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1064539019955 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1064539019956 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1064539019957 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1064539019958 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1064539019959 NAD(P) binding site [chemical binding]; other site 1064539019960 homotetramer interface [polypeptide binding]; other site 1064539019961 homodimer interface [polypeptide binding]; other site 1064539019962 active site 1064539019963 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1064539019964 ParB-like nuclease domain; Region: ParBc; pfam02195 1064539019965 Helix-turn-helix domain; Region: HTH_31; pfam13560 1064539019966 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1064539019967 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539019968 P-loop; other site 1064539019969 Magnesium ion binding site [ion binding]; other site 1064539019970 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539019971 Magnesium ion binding site [ion binding]; other site 1064539019972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539019973 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1064539019974 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1064539019975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019976 dimer interface [polypeptide binding]; other site 1064539019977 conserved gate region; other site 1064539019978 putative PBP binding loops; other site 1064539019979 ABC-ATPase subunit interface; other site 1064539019980 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1064539019981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539019982 dimer interface [polypeptide binding]; other site 1064539019983 conserved gate region; other site 1064539019984 putative PBP binding loops; other site 1064539019985 ABC-ATPase subunit interface; other site 1064539019986 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1064539019987 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1064539019988 Walker A/P-loop; other site 1064539019989 ATP binding site [chemical binding]; other site 1064539019990 Q-loop/lid; other site 1064539019991 ABC transporter signature motif; other site 1064539019992 Walker B; other site 1064539019993 D-loop; other site 1064539019994 H-loop/switch region; other site 1064539019995 TOBE domain; Region: TOBE_2; pfam08402 1064539019996 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1064539019997 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1064539019998 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064539019999 L-lactate permease; Region: Lactate_perm; cl00701 1064539020000 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1064539020001 Predicted flavoprotein [General function prediction only]; Region: COG0431 1064539020002 PAS domain; Region: PAS_9; pfam13426 1064539020003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1064539020004 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539020005 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539020006 dimer interface [polypeptide binding]; other site 1064539020007 putative CheW interface [polypeptide binding]; other site 1064539020008 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1064539020009 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1064539020010 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064539020011 Walker A/P-loop; other site 1064539020012 ATP binding site [chemical binding]; other site 1064539020013 Q-loop/lid; other site 1064539020014 ABC transporter signature motif; other site 1064539020015 Walker B; other site 1064539020016 D-loop; other site 1064539020017 H-loop/switch region; other site 1064539020018 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1064539020019 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064539020020 Walker A/P-loop; other site 1064539020021 ATP binding site [chemical binding]; other site 1064539020022 Q-loop/lid; other site 1064539020023 ABC transporter signature motif; other site 1064539020024 Walker B; other site 1064539020025 D-loop; other site 1064539020026 H-loop/switch region; other site 1064539020027 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064539020028 TM-ABC transporter signature motif; other site 1064539020029 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14702302, 2195019; Product type t : transporter 1064539020030 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14702302, 2195019; Product type t : transporter 1064539020031 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1064539020032 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064539020033 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1064539020034 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1064539020035 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1064539020036 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1064539020037 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1064539020038 metal binding site [ion binding]; metal-binding site 1064539020039 putative dimer interface [polypeptide binding]; other site 1064539020040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539020041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539020042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064539020043 putative substrate translocation pore; other site 1064539020044 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1064539020045 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1064539020046 putative acyl-acceptor binding pocket; other site 1064539020047 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539020048 acyl-activating enzyme (AAE) consensus motif; other site 1064539020049 AMP binding site [chemical binding]; other site 1064539020050 active site 1064539020051 CoA binding site [chemical binding]; other site 1064539020052 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1064539020053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539020054 S-adenosylmethionine binding site [chemical binding]; other site 1064539020055 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1064539020056 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1064539020057 putative metal binding site [ion binding]; other site 1064539020058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1064539020059 Serine hydrolase; Region: Ser_hydrolase; cl17834 1064539020060 Predicted membrane protein [Function unknown]; Region: COG1971 1064539020061 Domain of unknown function DUF; Region: DUF204; pfam02659 1064539020062 Domain of unknown function DUF; Region: DUF204; pfam02659 1064539020063 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15375141, 7921238; Product type rc : receptor 1064539020064 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15375141, 7921238; Product type rc : receptor 1064539020065 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1064539020066 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064539020067 EamA-like transporter family; Region: EamA; pfam00892 1064539020068 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1064539020069 classical (c) SDRs; Region: SDR_c; cd05233 1064539020070 NAD(P) binding site [chemical binding]; other site 1064539020071 active site 1064539020072 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 1064539020073 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1064539020074 active site 1064539020075 catalytic site [active] 1064539020076 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1064539020077 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1064539020078 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 1064539020079 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539020080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539020081 active site 1064539020082 phosphorylation site [posttranslational modification] 1064539020083 intermolecular recognition site; other site 1064539020084 dimerization interface [polypeptide binding]; other site 1064539020085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539020086 PAS fold; Region: PAS_3; pfam08447 1064539020087 putative active site [active] 1064539020088 heme pocket [chemical binding]; other site 1064539020089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539020090 dimer interface [polypeptide binding]; other site 1064539020091 phosphorylation site [posttranslational modification] 1064539020092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539020093 ATP binding site [chemical binding]; other site 1064539020094 Mg2+ binding site [ion binding]; other site 1064539020095 G-X-G motif; other site 1064539020096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539020097 active site 1064539020098 phosphorylation site [posttranslational modification] 1064539020099 intermolecular recognition site; other site 1064539020100 dimerization interface [polypeptide binding]; other site 1064539020101 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1064539020102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1064539020103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1064539020104 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064539020105 dimerization interface [polypeptide binding]; other site 1064539020106 GAF domain; Region: GAF; pfam01590 1064539020107 GAF domain; Region: GAF_2; pfam13185 1064539020108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539020109 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1064539020110 dimer interface [polypeptide binding]; other site 1064539020111 phosphorylation site [posttranslational modification] 1064539020112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539020113 ATP binding site [chemical binding]; other site 1064539020114 Mg2+ binding site [ion binding]; other site 1064539020115 G-X-G motif; other site 1064539020116 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539020117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539020118 active site 1064539020119 phosphorylation site [posttranslational modification] 1064539020120 intermolecular recognition site; other site 1064539020121 dimerization interface [polypeptide binding]; other site 1064539020122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539020123 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539020124 active site 1064539020125 phosphorylation site [posttranslational modification] 1064539020126 intermolecular recognition site; other site 1064539020127 dimerization interface [polypeptide binding]; other site 1064539020128 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539020129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539020130 active site 1064539020131 phosphorylation site [posttranslational modification] 1064539020132 intermolecular recognition site; other site 1064539020133 dimerization interface [polypeptide binding]; other site 1064539020134 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1064539020135 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539020136 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539020137 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539020138 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539020139 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539020140 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064539020141 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1064539020142 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1064539020143 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1064539020144 dinuclear metal binding motif [ion binding]; other site 1064539020145 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1064539020146 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539020147 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539020148 dimer interface [polypeptide binding]; other site 1064539020149 putative CheW interface [polypeptide binding]; other site 1064539020150 PilZ domain; Region: PilZ; pfam07238 1064539020151 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1064539020152 heme-binding site [chemical binding]; other site 1064539020153 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064539020154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539020155 dimer interface [polypeptide binding]; other site 1064539020156 putative CheW interface [polypeptide binding]; other site 1064539020157 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1064539020158 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1064539020159 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1064539020160 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1064539020161 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1064539020162 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 1064539020163 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1064539020164 Walker A/P-loop; other site 1064539020165 ATP binding site [chemical binding]; other site 1064539020166 Q-loop/lid; other site 1064539020167 ABC transporter signature motif; other site 1064539020168 Walker B; other site 1064539020169 D-loop; other site 1064539020170 H-loop/switch region; other site 1064539020171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539020172 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1064539020173 Walker A/P-loop; other site 1064539020174 ATP binding site [chemical binding]; other site 1064539020175 ABC transporter; Region: ABC_tran; pfam00005 1064539020176 Q-loop/lid; other site 1064539020177 ABC transporter signature motif; other site 1064539020178 Walker B; other site 1064539020179 D-loop; other site 1064539020180 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1064539020181 active site 1064539020182 iron coordination sites [ion binding]; other site 1064539020183 substrate binding pocket [chemical binding]; other site 1064539020184 thioester reductase domain; Region: Thioester-redct; TIGR01746 1064539020185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064539020186 NAD(P) binding site [chemical binding]; other site 1064539020187 active site 1064539020188 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539020189 AMP binding site [chemical binding]; other site 1064539020190 active site 1064539020191 CoA binding site [chemical binding]; other site 1064539020192 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1064539020193 AMP binding site [chemical binding]; other site 1064539020194 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1064539020195 Condensation domain; Region: Condensation; pfam00668 1064539020196 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539020197 acyl-activating enzyme (AAE) consensus motif; other site 1064539020198 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1064539020199 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539020200 acyl-activating enzyme (AAE) consensus motif; other site 1064539020201 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1064539020202 acyl-activating enzyme (AAE) consensus motif; other site 1064539020203 AMP binding site [chemical binding]; other site 1064539020204 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1064539020205 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1064539020206 AMP-binding enzyme; Region: AMP-binding; pfam00501 1064539020207 acyl-activating enzyme (AAE) consensus motif; other site 1064539020208 AMP binding site [chemical binding]; other site 1064539020209 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1064539020210 Condensation domain; Region: Condensation; pfam00668 1064539020211 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064539020212 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 1064539020213 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1064539020214 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1064539020215 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1064539020216 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1064539020217 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1064539020218 Walker A/P-loop; other site 1064539020219 ATP binding site [chemical binding]; other site 1064539020220 Q-loop/lid; other site 1064539020221 ABC transporter signature motif; other site 1064539020222 Walker B; other site 1064539020223 D-loop; other site 1064539020224 H-loop/switch region; other site 1064539020225 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1064539020226 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1064539020227 Walker A/P-loop; other site 1064539020228 ATP binding site [chemical binding]; other site 1064539020229 Q-loop/lid; other site 1064539020230 ABC transporter signature motif; other site 1064539020231 Walker B; other site 1064539020232 D-loop; other site 1064539020233 H-loop/switch region; other site 1064539020234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539020235 putative PBP binding loops; other site 1064539020236 dimer interface [polypeptide binding]; other site 1064539020237 ABC-ATPase subunit interface; other site 1064539020238 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1064539020239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064539020240 dimer interface [polypeptide binding]; other site 1064539020241 conserved gate region; other site 1064539020242 putative PBP binding loops; other site 1064539020243 ABC-ATPase subunit interface; other site 1064539020244 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 1064539020245 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1064539020246 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1064539020247 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1064539020248 N- and C-terminal domain interface [polypeptide binding]; other site 1064539020249 active site 1064539020250 MgATP binding site [chemical binding]; other site 1064539020251 catalytic site [active] 1064539020252 metal binding site [ion binding]; metal-binding site 1064539020253 glycerol binding site [chemical binding]; other site 1064539020254 homotetramer interface [polypeptide binding]; other site 1064539020255 homodimer interface [polypeptide binding]; other site 1064539020256 FBP binding site [chemical binding]; other site 1064539020257 protein IIAGlc interface [polypeptide binding]; other site 1064539020258 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1064539020259 classical (c) SDRs; Region: SDR_c; cd05233 1064539020260 NAD(P) binding site [chemical binding]; other site 1064539020261 active site 1064539020262 Predicted ATPase [General function prediction only]; Region: COG3911 1064539020263 AAA domain; Region: AAA_28; pfam13521 1064539020264 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1064539020265 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1064539020266 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1064539020267 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1064539020268 dimer interface [polypeptide binding]; other site 1064539020269 active site 1064539020270 citrylCoA binding site [chemical binding]; other site 1064539020271 NADH binding [chemical binding]; other site 1064539020272 cationic pore residues; other site 1064539020273 oxalacetate/citrate binding site [chemical binding]; other site 1064539020274 coenzyme A binding site [chemical binding]; other site 1064539020275 catalytic triad [active] 1064539020276 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1064539020277 active site 1064539020278 catalytic residues [active] 1064539020279 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1064539020280 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539020281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539020282 active site 1064539020283 phosphorylation site [posttranslational modification] 1064539020284 intermolecular recognition site; other site 1064539020285 dimerization interface [polypeptide binding]; other site 1064539020286 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1064539020287 CheC-like family; Region: CheC; pfam04509 1064539020288 potential frameshift: common BLAST hit: gi|375006691|ref|YP_004975475.1| Putative methyl-accepting chemotaxis sensory transducer 1064539020289 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539020290 dimer interface [polypeptide binding]; other site 1064539020291 putative CheW interface [polypeptide binding]; other site 1064539020292 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064539020293 dimer interface [polypeptide binding]; other site 1064539020294 putative CheW interface [polypeptide binding]; other site 1064539020295 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1064539020296 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1064539020297 CheW-like domain; Region: CheW; pfam01584 1064539020298 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1064539020299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539020300 active site 1064539020301 phosphorylation site [posttranslational modification] 1064539020302 intermolecular recognition site; other site 1064539020303 dimerization interface [polypeptide binding]; other site 1064539020304 CheB methylesterase; Region: CheB_methylest; pfam01339 1064539020305 HEAT repeats; Region: HEAT_2; pfam13646 1064539020306 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1064539020307 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1064539020308 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1064539020309 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15916598; Product type e : enzyme 1064539020310 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15916598; Product type e : enzyme 1064539020311 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539020312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539020313 active site 1064539020314 phosphorylation site [posttranslational modification] 1064539020315 intermolecular recognition site; other site 1064539020316 dimerization interface [polypeptide binding]; other site 1064539020317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539020318 PAS domain; Region: PAS_9; pfam13426 1064539020319 putative active site [active] 1064539020320 heme pocket [chemical binding]; other site 1064539020321 PAS domain S-box; Region: sensory_box; TIGR00229 1064539020322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064539020323 putative active site [active] 1064539020324 heme pocket [chemical binding]; other site 1064539020325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1064539020326 Histidine kinase; Region: HisKA_2; pfam07568 1064539020327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539020328 ATP binding site [chemical binding]; other site 1064539020329 Mg2+ binding site [ion binding]; other site 1064539020330 G-X-G motif; other site 1064539020331 CheC-like family; Region: CheC; pfam04509 1064539020332 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1064539020333 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539020334 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1064539020335 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1064539020336 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1064539020337 alpha-galactosidase; Provisional; Region: PRK15076 1064539020338 NAD(P) binding site [chemical binding]; other site 1064539020339 LDH/MDH dimer interface [polypeptide binding]; other site 1064539020340 substrate binding site [chemical binding]; other site 1064539020341 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1064539020342 beta-galactosidase; Region: BGL; TIGR03356 1064539020343 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1064539020344 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1064539020345 active site 1064539020346 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1064539020347 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1064539020348 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1064539020349 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1064539020350 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1064539020351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539020352 TPR motif; other site 1064539020353 binding surface 1064539020354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539020355 TPR motif; other site 1064539020356 binding surface 1064539020357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1064539020358 binding surface 1064539020359 TPR motif; other site 1064539020360 TPR repeat; Region: TPR_11; pfam13414 1064539020361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064539020362 binding surface 1064539020363 TPR motif; other site 1064539020364 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 1064539020365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064539020366 FeS/SAM binding site; other site 1064539020367 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1064539020368 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1064539020369 beta-galactosidase; Region: BGL; TIGR03356 1064539020370 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1064539020371 beta-galactosidase; Region: BGL; TIGR03356 1064539020372 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1064539020373 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1064539020374 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1064539020375 NodB motif; other site 1064539020376 active site 1064539020377 catalytic site [active] 1064539020378 metal binding site [ion binding]; metal-binding site 1064539020379 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1064539020380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539020381 S-adenosylmethionine binding site [chemical binding]; other site 1064539020382 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1064539020383 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1064539020384 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1064539020385 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1064539020386 NAD binding site [chemical binding]; other site 1064539020387 homodimer interface [polypeptide binding]; other site 1064539020388 homotetramer interface [polypeptide binding]; other site 1064539020389 active site 1064539020390 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1064539020391 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539020392 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539020393 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539020394 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1064539020395 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1064539020396 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1064539020397 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539020398 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539020399 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1064539020400 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539020401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064539020402 Walker A/P-loop; other site 1064539020403 ATP binding site [chemical binding]; other site 1064539020404 Q-loop/lid; other site 1064539020405 ABC transporter signature motif; other site 1064539020406 Walker B; other site 1064539020407 D-loop; other site 1064539020408 H-loop/switch region; other site 1064539020409 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1064539020410 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539020411 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064539020412 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1064539020413 ligand binding site [chemical binding]; other site 1064539020414 flexible hinge region; other site 1064539020415 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1064539020416 putative switch regulator; other site 1064539020417 non-specific DNA interactions [nucleotide binding]; other site 1064539020418 DNA binding site [nucleotide binding] 1064539020419 sequence specific DNA binding site [nucleotide binding]; other site 1064539020420 putative cAMP binding site [chemical binding]; other site 1064539020421 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1064539020422 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1064539020423 Surface antigen; Region: Bac_surface_Ag; pfam01103 1064539020424 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1064539020425 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1064539020426 CHASE2 domain; Region: CHASE2; pfam05226 1064539020427 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1064539020428 cyclase homology domain; Region: CHD; cd07302 1064539020429 nucleotidyl binding site; other site 1064539020430 metal binding site [ion binding]; metal-binding site 1064539020431 dimer interface [polypeptide binding]; other site 1064539020432 CHAT domain; Region: CHAT; cl17868 1064539020433 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539020434 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539020435 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 1064539020436 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1064539020437 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1064539020438 PAS fold; Region: PAS_4; pfam08448 1064539020439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539020440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539020441 ATP binding site [chemical binding]; other site 1064539020442 Mg2+ binding site [ion binding]; other site 1064539020443 G-X-G motif; other site 1064539020444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539020445 Response regulator receiver domain; Region: Response_reg; pfam00072 1064539020446 active site 1064539020447 phosphorylation site [posttranslational modification] 1064539020448 intermolecular recognition site; other site 1064539020449 dimerization interface [polypeptide binding]; other site 1064539020450 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1064539020451 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1064539020452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539020453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539020454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064539020455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064539020456 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 1064539020457 putative efflux protein, MATE family; Region: matE; TIGR00797 1064539020458 short chain dehydrogenase; Provisional; Region: PRK06179 1064539020459 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1064539020460 NADP binding site [chemical binding]; other site 1064539020461 active site 1064539020462 steroid binding site; other site 1064539020463 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064539020464 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539020465 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539020466 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1064539020467 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1064539020468 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1064539020469 catalytic residues [active] 1064539020470 catalytic nucleophile [active] 1064539020471 Presynaptic Site I dimer interface [polypeptide binding]; other site 1064539020472 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1064539020473 Synaptic Flat tetramer interface [polypeptide binding]; other site 1064539020474 Synaptic Site I dimer interface [polypeptide binding]; other site 1064539020475 DNA binding site [nucleotide binding] 1064539020476 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1064539020477 DNA-binding interface [nucleotide binding]; DNA binding site 1064539020478 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1064539020479 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064539020480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064539020481 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1064539020482 putative effector binding pocket; other site 1064539020483 putative dimerization interface [polypeptide binding]; other site 1064539020484 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1064539020485 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 1064539020486 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539020487 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539020488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064539020489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064539020490 dimer interface [polypeptide binding]; other site 1064539020491 phosphorylation site [posttranslational modification] 1064539020492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064539020493 ATP binding site [chemical binding]; other site 1064539020494 Mg2+ binding site [ion binding]; other site 1064539020495 G-X-G motif; other site 1064539020496 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539020497 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1064539020498 MobA/MobL family; Region: MobA_MobL; pfam03389 1064539020499 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1064539020500 OmpA family; Region: OmpA; pfam00691 1064539020501 ligand binding site [chemical binding]; other site 1064539020502 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1064539020503 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1064539020504 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1064539020505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1064539020506 Replication protein C N-terminal domain; Region: RP-C; pfam03428 1064539020507 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1064539020508 Family description; Region: UvrD_C_2; pfam13538 1064539020509 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064539020510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539020511 non-specific DNA binding site [nucleotide binding]; other site 1064539020512 salt bridge; other site 1064539020513 sequence-specific DNA binding site [nucleotide binding]; other site 1064539020514 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1064539020515 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539020516 P-loop; other site 1064539020517 Magnesium ion binding site [ion binding]; other site 1064539020518 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1064539020519 Magnesium ion binding site [ion binding]; other site 1064539020520 ParB-like nuclease domain; Region: ParB; smart00470 1064539020521 KorB domain; Region: KorB; pfam08535 1064539020522 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064539020523 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064539020524 active site 1064539020525 catalytic tetrad [active] 1064539020526 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1064539020527 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1064539020528 catalytic residues [active] 1064539020529 catalytic nucleophile [active] 1064539020530 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1064539020531 Synaptic Flat tetramer interface [polypeptide binding]; other site 1064539020532 Protein of unknown function (DUF465); Region: DUF465; pfam04325 1064539020533 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1064539020534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539020535 non-specific DNA binding site [nucleotide binding]; other site 1064539020536 salt bridge; other site 1064539020537 sequence-specific DNA binding site [nucleotide binding]; other site 1064539020538 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1064539020539 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064539020540 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064539020541 RTX N-terminal domain; Region: RTX; pfam02382 1064539020542 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1064539020543 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064539020544 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1064539020545 Walker A/P-loop; other site 1064539020546 ATP binding site [chemical binding]; other site 1064539020547 Q-loop/lid; other site 1064539020548 ABC transporter signature motif; other site 1064539020549 Walker B; other site 1064539020550 D-loop; other site 1064539020551 H-loop/switch region; other site 1064539020552 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 1064539020553 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821 1064539020554 putative heme binding site [chemical binding]; other site 1064539020555 putative substrate binding site [chemical binding]; other site 1064539020556 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1064539020557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1064539020558 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064539020559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064539020560 active site 1064539020561 phosphorylation site [posttranslational modification] 1064539020562 intermolecular recognition site; other site 1064539020563 dimerization interface [polypeptide binding]; other site 1064539020564 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064539020565 DNA binding residues [nucleotide binding] 1064539020566 dimerization interface [polypeptide binding]; other site 1064539020567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1064539020568 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539020569 Integrase core domain; Region: rve; pfam00665 1064539020570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1064539020571 Protein of unknown function (DUF805); Region: DUF805; cl01224 1064539020572 Transposase domain (DUF772); Region: DUF772; pfam05598 1064539020573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1064539020574 Integrase core domain; Region: rve; pfam00665 1064539020575 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1064539020576 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1064539020577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1064539020578 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1064539020579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1064539020580 Transposase; Region: HTH_Tnp_1; pfam01527 1064539020581 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1064539020582 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1064539020583 TIGR02594 family protein; Region: TIGR02594 1064539020584 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1064539020585 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 1064539020586 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1064539020587 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1064539020588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1064539020589 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 1064539020590 active site 1064539020591 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1064539020592 IHF dimer interface [polypeptide binding]; other site 1064539020593 IHF - DNA interface [nucleotide binding]; other site 1064539020594 Initiator Replication protein; Region: Rep_3; pfam01051 1064539020595 AAA ATPase domain; Region: AAA_16; pfam13191 1064539020596 AAA domain; Region: AAA_22; pfam13401 1064539020597 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1064539020598 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 1064539020599 Walker A motif; other site 1064539020600 ATP binding site [chemical binding]; other site 1064539020601 Walker B motif; other site 1064539020602 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1064539020603 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 1064539020604 VirB7 interaction site; other site 1064539020605 VirB8 protein; Region: VirB8; pfam04335 1064539020606 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 1064539020607 Domain of unknown function DUF87; Region: DUF87; pfam01935 1064539020608 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1064539020609 Walker A motif; other site 1064539020610 ATP binding site [chemical binding]; other site 1064539020611 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1064539020612 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 1064539020613 potential frameshift: common BLAST hit: gi|331700091|ref|YP_004336330.1| transposase IS4 family protein 1064539020614 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 1064539020615 Fic family protein [Function unknown]; Region: COG3177 1064539020616 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 1064539020617 Fic/DOC family; Region: Fic; pfam02661 1064539020618 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1064539020619 domain II; other site 1064539020620 domain IV; other site 1064539020621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064539020622 S-adenosylmethionine binding site [chemical binding]; other site 1064539020623 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1064539020624 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1064539020625 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 1064539020626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064539020627 Walker A motif; other site 1064539020628 ATP binding site [chemical binding]; other site 1064539020629 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1064539020630 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1064539020631 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1064539020632 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1064539020633 Helix-turn-helix domain; Region: HTH_36; pfam13730 1064539020634 Growth-Arrest-Specific Protein 2 Domain; Region: GAS2; cl02524 1064539020635 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064539020636 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064539020637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064539020638 non-specific DNA binding site [nucleotide binding]; other site 1064539020639 salt bridge; other site 1064539020640 sequence-specific DNA binding site [nucleotide binding]; other site 1064539020641 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1064539020642 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1064539020643 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1064539020644 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1064539020645 dimer interface [polypeptide binding]; other site 1064539020646 ssDNA binding site [nucleotide binding]; other site 1064539020647 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1064539020648 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1064539020649 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1064539020650 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1064539020651 RES domain; Region: RES; cl02411 1064539020652 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1064539020653 putative active site [active] 1064539020654 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1064539020655 AAA domain; Region: AAA_27; pfam13514 1064539020656 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1064539020657 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1064539020658 active site 1064539020659 metal binding site [ion binding]; metal-binding site 1064539020660 DNA binding site [nucleotide binding] 1064539020661 potential frameshift: common BLAST hit: gi|288957316|ref|YP_003447657.1| DNA helicase 1064539020662 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1064539020663 Part of AAA domain; Region: AAA_19; pfam13245 1064539020664 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1064539020665 AAA domain; Region: AAA_12; pfam13087 1064539020666 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1064539020667 putative active site [active] 1064539020668 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 1064539020669 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1064539020670 Helix-turn-helix domain; Region: HTH_38; pfam13936 1064539020671 DNA-binding interface [nucleotide binding]; DNA binding site