-- dump date 20140618_210412 -- class Genbank::misc_feature -- table misc_feature_note -- id note 862719000001 potential protein location (conserved protein of unknown function [Azospirillum lipoferum 4B]) that overlaps RNA (ribosomal RNA 16S ribosomal RNA) 862719000002 Transcriptional regulators [Transcription]; Region: FadR; COG2186 862719000003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719000004 DNA-binding site [nucleotide binding]; DNA binding site 862719000005 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 862719000006 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 862719000007 TPP-binding site [chemical binding]; other site 862719000008 PYR/PP interface [polypeptide binding]; other site 862719000009 dimer interface [polypeptide binding]; other site 862719000010 TPP binding site [chemical binding]; other site 862719000011 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 862719000012 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719000013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719000014 putative DNA binding site [nucleotide binding]; other site 862719000015 putative Zn2+ binding site [ion binding]; other site 862719000016 AsnC family; Region: AsnC_trans_reg; pfam01037 862719000017 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 862719000018 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 862719000019 acyl-activating enzyme (AAE) consensus motif; other site 862719000020 AMP binding site [chemical binding]; other site 862719000021 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 862719000022 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 862719000023 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 862719000024 putative trimer interface [polypeptide binding]; other site 862719000025 putative CoA binding site [chemical binding]; other site 862719000026 fumarate hydratase; Provisional; Region: PRK15389 862719000027 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 862719000028 Fumarase C-terminus; Region: Fumerase_C; pfam05683 862719000029 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 862719000030 CcdB protein; Region: CcdB; cl03380 862719000031 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 862719000032 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 862719000033 active site 862719000034 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 862719000035 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719000036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719000037 dimer interface [polypeptide binding]; other site 862719000038 phosphorylation site [posttranslational modification] 862719000039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000040 ATP binding site [chemical binding]; other site 862719000041 Mg2+ binding site [ion binding]; other site 862719000042 G-X-G motif; other site 862719000043 Pirin-related protein [General function prediction only]; Region: COG1741 862719000044 Pirin; Region: Pirin; pfam02678 862719000045 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 862719000046 Low molecular weight phosphatase family; Region: LMWPc; cl00105 862719000047 active site 862719000048 Domain of unknown function (DUF697); Region: DUF697; cl12064 862719000049 hypothetical protein; Provisional; Region: PRK05415 862719000050 YcjX-like family, DUF463; Region: DUF463; pfam04317 862719000051 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 862719000052 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 862719000053 active site 862719000054 catalytic residues [active] 862719000055 metal binding site [ion binding]; metal-binding site 862719000056 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 862719000057 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719000058 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719000059 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 862719000060 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 862719000061 carboxyltransferase (CT) interaction site; other site 862719000062 biotinylation site [posttranslational modification]; other site 862719000063 enoyl-CoA hydratase; Provisional; Region: PRK05995 862719000064 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719000065 substrate binding site [chemical binding]; other site 862719000066 oxyanion hole (OAH) forming residues; other site 862719000067 trimer interface [polypeptide binding]; other site 862719000068 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 862719000069 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719000070 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 862719000071 FAD binding site [chemical binding]; other site 862719000072 homotetramer interface [polypeptide binding]; other site 862719000073 substrate binding pocket [chemical binding]; other site 862719000074 catalytic base [active] 862719000075 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 862719000076 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719000077 dimer interface [polypeptide binding]; other site 862719000078 active site 862719000079 isovaleryl-CoA dehydrogenase; Region: PLN02519 862719000080 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 862719000081 substrate binding site [chemical binding]; other site 862719000082 FAD binding site [chemical binding]; other site 862719000083 catalytic base [active] 862719000084 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 862719000085 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 862719000086 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 862719000087 active site 862719000088 homopentamer interface [polypeptide binding]; other site 862719000089 PAS domain S-box; Region: sensory_box; TIGR00229 862719000090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000091 putative active site [active] 862719000092 heme pocket [chemical binding]; other site 862719000093 PAS fold; Region: PAS_4; pfam08448 862719000094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000095 putative active site [active] 862719000096 heme pocket [chemical binding]; other site 862719000097 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719000098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000099 putative active site [active] 862719000100 heme pocket [chemical binding]; other site 862719000101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719000102 dimer interface [polypeptide binding]; other site 862719000103 phosphorylation site [posttranslational modification] 862719000104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000105 ATP binding site [chemical binding]; other site 862719000106 Mg2+ binding site [ion binding]; other site 862719000107 G-X-G motif; other site 862719000108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000109 Response regulator receiver domain; Region: Response_reg; pfam00072 862719000110 active site 862719000111 phosphorylation site [posttranslational modification] 862719000112 intermolecular recognition site; other site 862719000113 dimerization interface [polypeptide binding]; other site 862719000114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719000115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719000116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719000117 dimerization interface [polypeptide binding]; other site 862719000118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719000119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719000120 putative substrate translocation pore; other site 862719000121 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 862719000122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719000123 Coenzyme A binding pocket [chemical binding]; other site 862719000124 Gram-negative porin; Region: Porin_4; pfam13609 862719000125 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 862719000126 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719000127 Walker A/P-loop; other site 862719000128 ATP binding site [chemical binding]; other site 862719000129 Q-loop/lid; other site 862719000130 ABC transporter signature motif; other site 862719000131 Walker B; other site 862719000132 D-loop; other site 862719000133 H-loop/switch region; other site 862719000134 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 862719000135 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719000136 ABC-ATPase subunit interface; other site 862719000137 dimer interface [polypeptide binding]; other site 862719000138 putative PBP binding regions; other site 862719000139 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 862719000140 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 862719000141 putative ligand binding residues [chemical binding]; other site 862719000142 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 862719000143 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 862719000144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719000145 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 862719000146 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719000147 N-terminal plug; other site 862719000148 ligand-binding site [chemical binding]; other site 862719000149 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 862719000150 Helix-turn-helix domain; Region: HTH_36; pfam13730 862719000151 Replication initiator protein A; Region: RPA; cl17860 862719000152 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719000153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719000154 non-specific DNA binding site [nucleotide binding]; other site 862719000155 salt bridge; other site 862719000156 sequence-specific DNA binding site [nucleotide binding]; other site 862719000157 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719000158 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719000159 P-loop; other site 862719000160 Magnesium ion binding site [ion binding]; other site 862719000161 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719000162 Magnesium ion binding site [ion binding]; other site 862719000163 ParB-like nuclease domain; Region: ParB; smart00470 862719000164 KorB domain; Region: KorB; pfam08535 862719000165 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 862719000166 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 862719000167 Uncharacterized conserved protein [Function unknown]; Region: COG4278 862719000168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719000169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719000170 dimerization interface [polypeptide binding]; other site 862719000171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000172 ATP binding site [chemical binding]; other site 862719000173 Mg2+ binding site [ion binding]; other site 862719000174 G-X-G motif; other site 862719000175 Response regulator receiver domain; Region: Response_reg; pfam00072 862719000176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000177 active site 862719000178 phosphorylation site [posttranslational modification] 862719000179 intermolecular recognition site; other site 862719000180 dimerization interface [polypeptide binding]; other site 862719000181 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 862719000182 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000183 PAS fold; Region: PAS_3; pfam08447 862719000184 putative active site [active] 862719000185 heme pocket [chemical binding]; other site 862719000186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719000187 dimer interface [polypeptide binding]; other site 862719000188 phosphorylation site [posttranslational modification] 862719000189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000190 ATP binding site [chemical binding]; other site 862719000191 Mg2+ binding site [ion binding]; other site 862719000192 G-X-G motif; other site 862719000193 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719000194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000195 active site 862719000196 phosphorylation site [posttranslational modification] 862719000197 intermolecular recognition site; other site 862719000198 dimerization interface [polypeptide binding]; other site 862719000199 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719000200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000201 active site 862719000202 phosphorylation site [posttranslational modification] 862719000203 intermolecular recognition site; other site 862719000204 dimerization interface [polypeptide binding]; other site 862719000205 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 862719000206 Strictosidine synthase; Region: Str_synth; pfam03088 862719000207 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719000208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719000209 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719000210 dimerization interface [polypeptide binding]; other site 862719000211 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 862719000212 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 862719000213 putative dimer interface [polypeptide binding]; other site 862719000214 [2Fe-2S] cluster binding site [ion binding]; other site 862719000215 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 862719000216 putative dimer interface [polypeptide binding]; other site 862719000217 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 862719000218 SLBB domain; Region: SLBB; pfam10531 862719000219 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 862719000220 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 862719000221 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719000222 catalytic loop [active] 862719000223 iron binding site [ion binding]; other site 862719000224 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 862719000225 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 862719000226 [4Fe-4S] binding site [ion binding]; other site 862719000227 molybdopterin cofactor binding site; other site 862719000228 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 862719000229 molybdopterin cofactor binding site; other site 862719000230 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 862719000231 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 862719000232 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 862719000233 dimer interface [polypeptide binding]; other site 862719000234 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719000235 metal binding site [ion binding]; metal-binding site 862719000236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 862719000237 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 862719000238 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 862719000239 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 862719000240 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719000241 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 862719000242 putative ligand binding site [chemical binding]; other site 862719000243 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719000244 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719000245 TM-ABC transporter signature motif; other site 862719000246 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719000247 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 862719000248 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719000249 TM-ABC transporter signature motif; other site 862719000250 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 862719000251 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719000252 Walker A/P-loop; other site 862719000253 ATP binding site [chemical binding]; other site 862719000254 Q-loop/lid; other site 862719000255 ABC transporter signature motif; other site 862719000256 Walker B; other site 862719000257 D-loop; other site 862719000258 H-loop/switch region; other site 862719000259 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 862719000260 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719000261 Walker A/P-loop; other site 862719000262 ATP binding site [chemical binding]; other site 862719000263 Q-loop/lid; other site 862719000264 ABC transporter signature motif; other site 862719000265 Walker B; other site 862719000266 D-loop; other site 862719000267 H-loop/switch region; other site 862719000268 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 862719000269 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 862719000270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719000271 active site 862719000272 motif I; other site 862719000273 motif II; other site 862719000274 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862719000275 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 862719000276 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 862719000277 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719000278 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 862719000279 putative N-terminal domain interface [polypeptide binding]; other site 862719000280 putative dimer interface [polypeptide binding]; other site 862719000281 putative substrate binding pocket (H-site) [chemical binding]; other site 862719000282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719000283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719000284 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 862719000285 putative effector binding pocket; other site 862719000286 putative dimerization interface [polypeptide binding]; other site 862719000287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719000288 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719000289 substrate binding pocket [chemical binding]; other site 862719000290 membrane-bound complex binding site; other site 862719000291 hinge residues; other site 862719000292 Uncharacterized conserved protein [Function unknown]; Region: COG1262 862719000293 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 862719000294 Domain of unknown function (DUF892); Region: DUF892; pfam05974 862719000295 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 862719000296 CoenzymeA binding site [chemical binding]; other site 862719000297 subunit interaction site [polypeptide binding]; other site 862719000298 PHB binding site; other site 862719000299 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 862719000300 23S rRNA interface [nucleotide binding]; other site 862719000301 L3 interface [polypeptide binding]; other site 862719000302 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 862719000303 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 862719000304 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 862719000305 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 862719000306 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 862719000307 trimer interface [polypeptide binding]; other site 862719000308 putative metal binding site [ion binding]; other site 862719000309 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 862719000310 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719000311 ligand binding site [chemical binding]; other site 862719000312 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 862719000313 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 862719000314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719000315 DNA-binding site [nucleotide binding]; DNA binding site 862719000316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719000317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719000318 homodimer interface [polypeptide binding]; other site 862719000319 catalytic residue [active] 862719000320 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 862719000321 trehalose synthase; Region: treS_nterm; TIGR02456 862719000322 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 862719000323 active site 862719000324 catalytic site [active] 862719000325 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 862719000326 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 862719000327 glycogen branching enzyme; Provisional; Region: PRK05402 862719000328 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 862719000329 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 862719000330 active site 862719000331 catalytic site [active] 862719000332 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 862719000333 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 862719000334 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 862719000335 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 862719000336 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 862719000337 active site 862719000338 catalytic site [active] 862719000339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000340 Response regulator receiver domain; Region: Response_reg; pfam00072 862719000341 active site 862719000342 phosphorylation site [posttranslational modification] 862719000343 intermolecular recognition site; other site 862719000344 dimerization interface [polypeptide binding]; other site 862719000345 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 862719000346 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 862719000347 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719000348 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719000349 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719000350 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 862719000351 active site 862719000352 DNA binding site [nucleotide binding] 862719000353 Int/Topo IB signature motif; other site 862719000354 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719000355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719000356 DNA binding residues [nucleotide binding] 862719000357 dimerization interface [polypeptide binding]; other site 862719000358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719000359 non-specific DNA binding site [nucleotide binding]; other site 862719000360 salt bridge; other site 862719000361 sequence-specific DNA binding site [nucleotide binding]; other site 862719000362 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719000363 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 862719000364 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 862719000365 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862719000366 active site residue [active] 862719000367 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 862719000368 AAA domain; Region: AAA_30; pfam13604 862719000369 Family description; Region: UvrD_C_2; pfam13538 862719000370 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 862719000371 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 862719000372 Nuclease-related domain; Region: NERD; pfam08378 862719000373 Protein kinase domain; Region: Pkinase; pfam00069 862719000374 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719000375 active site 862719000376 ATP binding site [chemical binding]; other site 862719000377 substrate binding site [chemical binding]; other site 862719000378 activation loop (A-loop); other site 862719000379 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719000380 AAA domain; Region: AAA_11; pfam13086 862719000381 Part of AAA domain; Region: AAA_19; pfam13245 862719000382 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 862719000383 AAA domain; Region: AAA_30; pfam13604 862719000384 AAA domain; Region: AAA_12; pfam13087 862719000385 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 862719000386 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 862719000387 AIPR protein; Region: AIPR; pfam10592 862719000388 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 862719000389 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 862719000390 Int/Topo IB signature motif; other site 862719000391 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 862719000392 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719000393 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719000394 Evidence 7 : Gene remnant 862719000395 Evidence 7 : Gene remnant; Product type pm : putative membrane component 862719000396 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 862719000397 Bacterial Ig-like domain; Region: Big_5; pfam13205 862719000398 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 862719000399 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719000400 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719000401 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719000402 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719000403 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719000404 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719000405 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719000406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000407 active site 862719000408 phosphorylation site [posttranslational modification] 862719000409 intermolecular recognition site; other site 862719000410 dimerization interface [polypeptide binding]; other site 862719000411 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 862719000412 DNA binding site [nucleotide binding] 862719000413 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 862719000414 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 862719000415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719000416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719000417 dimer interface [polypeptide binding]; other site 862719000418 phosphorylation site [posttranslational modification] 862719000419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000420 ATP binding site [chemical binding]; other site 862719000421 Mg2+ binding site [ion binding]; other site 862719000422 G-X-G motif; other site 862719000423 Transposase; Region: DEDD_Tnp_IS110; pfam01548 862719000424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 862719000425 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 862719000426 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719000427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000428 active site 862719000429 phosphorylation site [posttranslational modification] 862719000430 intermolecular recognition site; other site 862719000431 dimerization interface [polypeptide binding]; other site 862719000432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719000433 DNA binding site [nucleotide binding] 862719000434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719000435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000436 ATP binding site [chemical binding]; other site 862719000437 Mg2+ binding site [ion binding]; other site 862719000438 G-X-G motif; other site 862719000439 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 862719000440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719000441 putative DNA binding site [nucleotide binding]; other site 862719000442 putative Zn2+ binding site [ion binding]; other site 862719000443 AsnC family; Region: AsnC_trans_reg; pfam01037 862719000444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000445 PAS domain; Region: PAS_9; pfam13426 862719000446 putative active site [active] 862719000447 heme pocket [chemical binding]; other site 862719000448 Tar ligand binding domain homologue; Region: TarH; pfam02203 862719000449 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719000450 HAMP domain; Region: HAMP; pfam00672 862719000451 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719000452 putative CheW interface [polypeptide binding]; other site 862719000453 PilZ domain; Region: PilZ; pfam07238 862719000454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719000455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719000456 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 862719000457 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719000458 AMP-binding enzyme; Region: AMP-binding; pfam00501 862719000459 acyl-activating enzyme (AAE) consensus motif; other site 862719000460 active site 862719000461 AMP binding site [chemical binding]; other site 862719000462 CoA binding site [chemical binding]; other site 862719000463 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719000464 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719000465 Walker A/P-loop; other site 862719000466 ATP binding site [chemical binding]; other site 862719000467 Q-loop/lid; other site 862719000468 ABC transporter signature motif; other site 862719000469 Walker B; other site 862719000470 D-loop; other site 862719000471 H-loop/switch region; other site 862719000472 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 862719000473 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 862719000474 acyl-activating enzyme (AAE) consensus motif; other site 862719000475 putative AMP binding site [chemical binding]; other site 862719000476 putative active site [active] 862719000477 putative CoA binding site [chemical binding]; other site 862719000478 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719000479 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719000480 TM-ABC transporter signature motif; other site 862719000481 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719000482 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719000483 TM-ABC transporter signature motif; other site 862719000484 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719000485 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 862719000486 putative ligand binding site [chemical binding]; other site 862719000487 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719000488 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719000489 Walker A/P-loop; other site 862719000490 ATP binding site [chemical binding]; other site 862719000491 Q-loop/lid; other site 862719000492 ABC transporter signature motif; other site 862719000493 Walker B; other site 862719000494 D-loop; other site 862719000495 H-loop/switch region; other site 862719000496 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 862719000497 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719000498 acyl-activating enzyme (AAE) consensus motif; other site 862719000499 AMP binding site [chemical binding]; other site 862719000500 active site 862719000501 CoA binding site [chemical binding]; other site 862719000502 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 862719000503 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719000504 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 862719000505 N-terminal domain interface [polypeptide binding]; other site 862719000506 Response regulator receiver domain; Region: Response_reg; pfam00072 862719000507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000508 active site 862719000509 phosphorylation site [posttranslational modification] 862719000510 intermolecular recognition site; other site 862719000511 dimerization interface [polypeptide binding]; other site 862719000512 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719000513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000514 NAD(P) binding site [chemical binding]; other site 862719000515 active site 862719000516 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 862719000517 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 862719000518 putative active site [active] 862719000519 TPR repeat; Region: TPR_11; pfam13414 862719000520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719000521 binding surface 862719000522 TPR motif; other site 862719000523 Predicted integral membrane protein [Function unknown]; Region: COG5616 862719000524 GAF domain; Region: GAF_3; pfam13492 862719000525 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 862719000526 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 862719000527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719000528 Predicted membrane protein [Function unknown]; Region: COG4267 862719000529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719000530 S-adenosylmethionine binding site [chemical binding]; other site 862719000531 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719000532 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719000533 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719000534 dimerization interface [polypeptide binding]; other site 862719000535 putative DNA binding site [nucleotide binding]; other site 862719000536 putative Zn2+ binding site [ion binding]; other site 862719000537 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 862719000538 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719000539 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 862719000540 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 862719000541 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 862719000542 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 862719000543 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719000544 Peptidase family M23; Region: Peptidase_M23; pfam01551 862719000545 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862719000546 Protein export membrane protein; Region: SecD_SecF; cl14618 862719000547 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862719000548 active site residue [active] 862719000549 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719000550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719000551 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 862719000552 dimerization interface [polypeptide binding]; other site 862719000553 substrate binding pocket [chemical binding]; other site 862719000554 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719000555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719000556 NAD(P) binding site [chemical binding]; other site 862719000557 active site 862719000558 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 862719000559 TPP-binding site [chemical binding]; other site 862719000560 dimer interface [polypeptide binding]; other site 862719000561 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 862719000562 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862719000563 PYR/PP interface [polypeptide binding]; other site 862719000564 dimer interface [polypeptide binding]; other site 862719000565 TPP binding site [chemical binding]; other site 862719000566 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719000567 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719000568 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 862719000569 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 862719000570 DctM-like transporters; Region: DctM; pfam06808 862719000571 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 862719000572 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 862719000573 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 862719000574 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 862719000575 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 862719000576 substrate binding site [chemical binding]; other site 862719000577 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 862719000578 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 862719000579 substrate binding site [chemical binding]; other site 862719000580 ligand binding site [chemical binding]; other site 862719000581 FAD binding domain; Region: FAD_binding_2; pfam00890 862719000582 Isochorismatase family; Region: Isochorismatase; pfam00857 862719000583 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 862719000584 catalytic triad [active] 862719000585 conserved cis-peptide bond; other site 862719000586 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 862719000587 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 862719000588 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 862719000589 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 862719000590 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 862719000591 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 862719000592 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 862719000593 tetramer interface [polypeptide binding]; other site 862719000594 active site 862719000595 Mg2+/Mn2+ binding site [ion binding]; other site 862719000596 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719000597 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719000598 Walker A/P-loop; other site 862719000599 ATP binding site [chemical binding]; other site 862719000600 Q-loop/lid; other site 862719000601 ABC transporter signature motif; other site 862719000602 Walker B; other site 862719000603 D-loop; other site 862719000604 H-loop/switch region; other site 862719000605 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719000606 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719000607 Walker A/P-loop; other site 862719000608 ATP binding site [chemical binding]; other site 862719000609 Q-loop/lid; other site 862719000610 ABC transporter signature motif; other site 862719000611 Walker B; other site 862719000612 D-loop; other site 862719000613 H-loop/switch region; other site 862719000614 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719000615 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719000616 TM-ABC transporter signature motif; other site 862719000617 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719000618 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719000619 TM-ABC transporter signature motif; other site 862719000620 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719000621 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 862719000622 putative ligand binding site [chemical binding]; other site 862719000623 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 862719000624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719000625 DNA-binding site [nucleotide binding]; DNA binding site 862719000626 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 862719000627 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862719000628 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719000629 dimerization interface [polypeptide binding]; other site 862719000630 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719000631 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719000632 dimer interface [polypeptide binding]; other site 862719000633 putative CheW interface [polypeptide binding]; other site 862719000634 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 862719000635 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862719000636 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862719000637 ABC transporter; Region: ABC_tran_2; pfam12848 862719000638 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862719000639 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 862719000640 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 862719000641 putative catalytic cysteine [active] 862719000642 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 862719000643 putative active site [active] 862719000644 metal binding site [ion binding]; metal-binding site 862719000645 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 862719000646 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719000647 active site 862719000648 substrate binding site [chemical binding]; other site 862719000649 activation loop (A-loop); other site 862719000650 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 862719000651 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 862719000652 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719000653 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719000654 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719000655 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 862719000656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719000657 Walker A/P-loop; other site 862719000658 ATP binding site [chemical binding]; other site 862719000659 Q-loop/lid; other site 862719000660 ABC transporter signature motif; other site 862719000661 Walker B; other site 862719000662 D-loop; other site 862719000663 H-loop/switch region; other site 862719000664 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 862719000665 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 862719000666 catalytic triad [active] 862719000667 dimer interface [polypeptide binding]; other site 862719000668 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 862719000669 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 862719000670 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 862719000671 enolase; Provisional; Region: eno; PRK00077 862719000672 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 862719000673 dimer interface [polypeptide binding]; other site 862719000674 metal binding site [ion binding]; metal-binding site 862719000675 substrate binding pocket [chemical binding]; other site 862719000676 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719000677 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 862719000678 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 862719000679 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 862719000680 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 862719000681 active site residue [active] 862719000682 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 862719000683 active site residue [active] 862719000684 flagellar motor switch protein FliN; Region: fliN; TIGR02480 862719000685 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 862719000686 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719000687 catalytic residue [active] 862719000688 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 862719000689 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 862719000690 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 862719000691 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 862719000692 GatB domain; Region: GatB_Yqey; smart00845 862719000693 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000694 PAS fold; Region: PAS_3; pfam08447 862719000695 putative active site [active] 862719000696 heme pocket [chemical binding]; other site 862719000697 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862719000698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719000699 putative active site [active] 862719000700 heme pocket [chemical binding]; other site 862719000701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719000702 dimer interface [polypeptide binding]; other site 862719000703 phosphorylation site [posttranslational modification] 862719000704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719000705 ATP binding site [chemical binding]; other site 862719000706 Mg2+ binding site [ion binding]; other site 862719000707 G-X-G motif; other site 862719000708 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 862719000709 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 862719000710 metal binding site [ion binding]; metal-binding site 862719000711 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 862719000712 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 862719000713 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 862719000714 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 862719000715 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 862719000716 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 862719000717 Cupin domain; Region: Cupin_2; cl17218 862719000718 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 862719000719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719000720 putative substrate translocation pore; other site 862719000721 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 862719000722 thiamine phosphate binding site [chemical binding]; other site 862719000723 active site 862719000724 pyrophosphate binding site [ion binding]; other site 862719000725 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719000726 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719000727 DNA-binding site [nucleotide binding]; DNA binding site 862719000728 FCD domain; Region: FCD; pfam07729 862719000729 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 862719000730 pyruvate kinase; Provisional; Region: PRK06247 862719000731 domain interfaces; other site 862719000732 active site 862719000733 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 862719000734 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719000735 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 862719000736 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 862719000737 putative active site [active] 862719000738 Zn binding site [ion binding]; other site 862719000739 FOG: CBS domain [General function prediction only]; Region: COG0517 862719000740 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 862719000741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719000742 Coenzyme A binding pocket [chemical binding]; other site 862719000743 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 862719000744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719000745 putative substrate translocation pore; other site 862719000746 hypothetical protein; Provisional; Region: PRK10621 862719000747 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862719000748 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 862719000749 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 862719000750 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 862719000751 FOG: CBS domain [General function prediction only]; Region: COG0517 862719000752 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 862719000753 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 862719000754 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 862719000755 ligand binding site [chemical binding]; other site 862719000756 homodimer interface [polypeptide binding]; other site 862719000757 NAD(P) binding site [chemical binding]; other site 862719000758 trimer interface B [polypeptide binding]; other site 862719000759 trimer interface A [polypeptide binding]; other site 862719000760 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 862719000761 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 862719000762 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 862719000763 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 862719000764 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 862719000765 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 862719000766 active site 862719000767 catalytic site [active] 862719000768 tetramer interface [polypeptide binding]; other site 862719000769 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 862719000770 active site 862719000771 homotetramer interface [polypeptide binding]; other site 862719000772 glyoxylate carboligase; Provisional; Region: PRK11269 862719000773 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 862719000774 PYR/PP interface [polypeptide binding]; other site 862719000775 dimer interface [polypeptide binding]; other site 862719000776 TPP binding site [chemical binding]; other site 862719000777 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 862719000778 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 862719000779 TPP-binding site [chemical binding]; other site 862719000780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719000781 dimerization interface [polypeptide binding]; other site 862719000782 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719000783 dimer interface [polypeptide binding]; other site 862719000784 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719000785 putative CheW interface [polypeptide binding]; other site 862719000786 transcriptional regulator; Provisional; Region: PRK10632 862719000787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719000788 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719000789 putative effector binding pocket; other site 862719000790 dimerization interface [polypeptide binding]; other site 862719000791 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 862719000792 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 862719000793 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719000794 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719000795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719000796 DNA-binding site [nucleotide binding]; DNA binding site 862719000797 FCD domain; Region: FCD; pfam07729 862719000798 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 862719000799 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 862719000800 PYR/PP interface [polypeptide binding]; other site 862719000801 dimer interface [polypeptide binding]; other site 862719000802 TPP binding site [chemical binding]; other site 862719000803 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 862719000804 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 862719000805 TPP-binding site; other site 862719000806 dimer interface [polypeptide binding]; other site 862719000807 formyl-coenzyme A transferase; Provisional; Region: PRK05398 862719000808 CoA-transferase family III; Region: CoA_transf_3; pfam02515 862719000809 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 862719000810 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 862719000811 CoA-ligase; Region: Ligase_CoA; pfam00549 862719000812 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 862719000813 CoA binding domain; Region: CoA_binding; pfam02629 862719000814 CoA-ligase; Region: Ligase_CoA; pfam00549 862719000815 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 862719000816 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719000817 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719000818 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 862719000819 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 862719000820 NAD(P) binding site [chemical binding]; other site 862719000821 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 862719000822 BON domain; Region: BON; pfam04972 862719000823 BON domain; Region: BON; pfam04972 862719000824 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 862719000825 active site 862719000826 metal binding site [ion binding]; metal-binding site 862719000827 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 862719000828 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 862719000829 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 862719000830 putative active site [active] 862719000831 putative substrate binding site [chemical binding]; other site 862719000832 putative cosubstrate binding site; other site 862719000833 catalytic site [active] 862719000834 two-component response regulator; Provisional; Region: PRK09191 862719000835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719000836 active site 862719000837 phosphorylation site [posttranslational modification] 862719000838 intermolecular recognition site; other site 862719000839 dimerization interface [polypeptide binding]; other site 862719000840 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719000841 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 862719000842 acyl-activating enzyme (AAE) consensus motif; other site 862719000843 AMP binding site [chemical binding]; other site 862719000844 active site 862719000845 CoA binding site [chemical binding]; other site 862719000846 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 862719000847 putative active site [active] 862719000848 YdjC motif; other site 862719000849 Mg binding site [ion binding]; other site 862719000850 putative homodimer interface [polypeptide binding]; other site 862719000851 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 862719000852 EamA-like transporter family; Region: EamA; pfam00892 862719000853 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719000854 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 862719000855 peptide binding site [polypeptide binding]; other site 862719000856 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719000857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719000858 dimer interface [polypeptide binding]; other site 862719000859 conserved gate region; other site 862719000860 putative PBP binding loops; other site 862719000861 ABC-ATPase subunit interface; other site 862719000862 dipeptide transporter; Provisional; Region: PRK10913 862719000863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719000864 putative PBP binding loops; other site 862719000865 dimer interface [polypeptide binding]; other site 862719000866 ABC-ATPase subunit interface; other site 862719000867 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 862719000868 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719000869 Walker A/P-loop; other site 862719000870 ATP binding site [chemical binding]; other site 862719000871 Q-loop/lid; other site 862719000872 ABC transporter signature motif; other site 862719000873 Walker B; other site 862719000874 D-loop; other site 862719000875 H-loop/switch region; other site 862719000876 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719000877 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 862719000878 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719000879 Walker A/P-loop; other site 862719000880 ATP binding site [chemical binding]; other site 862719000881 Q-loop/lid; other site 862719000882 ABC transporter signature motif; other site 862719000883 Walker B; other site 862719000884 D-loop; other site 862719000885 H-loop/switch region; other site 862719000886 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719000887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 862719000888 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 862719000889 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 862719000890 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 862719000891 tandem repeat interface [polypeptide binding]; other site 862719000892 oligomer interface [polypeptide binding]; other site 862719000893 active site residues [active] 862719000894 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 862719000895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719000896 S-adenosylmethionine binding site [chemical binding]; other site 862719000897 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 862719000898 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 862719000899 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 862719000900 substrate binding pocket [chemical binding]; other site 862719000901 chain length determination region; other site 862719000902 substrate-Mg2+ binding site; other site 862719000903 catalytic residues [active] 862719000904 aspartate-rich region 1; other site 862719000905 active site lid residues [active] 862719000906 aspartate-rich region 2; other site 862719000907 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719000908 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719000909 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 862719000910 active site 862719000911 metal binding site [ion binding]; metal-binding site 862719000912 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719000913 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862719000914 Predicted membrane protein [Function unknown]; Region: COG2860 862719000915 UPF0126 domain; Region: UPF0126; pfam03458 862719000916 UPF0126 domain; Region: UPF0126; pfam03458 862719000917 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862719000918 metal-binding site [ion binding] 862719000919 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 862719000920 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862719000921 metal-binding site [ion binding] 862719000922 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862719000923 Soluble P-type ATPase [General function prediction only]; Region: COG4087 862719000924 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 862719000925 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 862719000926 DNA binding residues [nucleotide binding] 862719000927 dimer interface [polypeptide binding]; other site 862719000928 copper binding site [ion binding]; other site 862719000929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719000930 putative substrate translocation pore; other site 862719000931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719000932 Protein of unknown function (DUF4106); Region: DUF4106; pfam13388 862719000933 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 862719000934 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719000935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719000936 S-adenosylmethionine binding site [chemical binding]; other site 862719000937 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 862719000938 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 862719000939 hypothetical protein; Provisional; Region: PRK06034 862719000940 Chorismate mutase type II; Region: CM_2; smart00830 862719000941 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 862719000942 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719000943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719000944 homodimer interface [polypeptide binding]; other site 862719000945 catalytic residue [active] 862719000946 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 862719000947 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 862719000948 cytosine deaminase; Validated; Region: PRK07572 862719000949 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 862719000950 active site 862719000951 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719000952 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719000953 TM-ABC transporter signature motif; other site 862719000954 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719000955 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719000956 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719000957 TM-ABC transporter signature motif; other site 862719000958 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 862719000959 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 862719000960 Walker A/P-loop; other site 862719000961 ATP binding site [chemical binding]; other site 862719000962 Q-loop/lid; other site 862719000963 ABC transporter signature motif; other site 862719000964 Walker B; other site 862719000965 D-loop; other site 862719000966 H-loop/switch region; other site 862719000967 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 862719000968 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 862719000969 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 862719000970 putative ligand binding site [chemical binding]; other site 862719000971 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719000972 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719000973 putative DNA binding site [nucleotide binding]; other site 862719000974 putative Zn2+ binding site [ion binding]; other site 862719000975 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719000976 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719000977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719000978 Walker A/P-loop; other site 862719000979 ATP binding site [chemical binding]; other site 862719000980 Q-loop/lid; other site 862719000981 ABC transporter signature motif; other site 862719000982 Walker B; other site 862719000983 D-loop; other site 862719000984 H-loop/switch region; other site 862719000985 TOBE domain; Region: TOBE_2; pfam08402 862719000986 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 862719000987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719000988 dimer interface [polypeptide binding]; other site 862719000989 conserved gate region; other site 862719000990 putative PBP binding loops; other site 862719000991 ABC-ATPase subunit interface; other site 862719000992 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719000993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719000994 dimer interface [polypeptide binding]; other site 862719000995 conserved gate region; other site 862719000996 putative PBP binding loops; other site 862719000997 ABC-ATPase subunit interface; other site 862719000998 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 862719000999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 862719001000 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862719001001 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 862719001002 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719001003 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 862719001004 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 862719001005 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 862719001006 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 862719001007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719001008 Coenzyme A binding pocket [chemical binding]; other site 862719001009 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 862719001010 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 862719001011 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 862719001012 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 862719001013 ring oligomerisation interface [polypeptide binding]; other site 862719001014 ATP/Mg binding site [chemical binding]; other site 862719001015 stacking interactions; other site 862719001016 hinge regions; other site 862719001017 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 862719001018 oligomerisation interface [polypeptide binding]; other site 862719001019 mobile loop; other site 862719001020 roof hairpin; other site 862719001021 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 862719001022 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 862719001023 tetramer interface [polypeptide binding]; other site 862719001024 catalytic Zn binding site [ion binding]; other site 862719001025 NADP binding site [chemical binding]; other site 862719001026 putative oxidoreductase; Provisional; Region: PRK11579 862719001027 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 862719001028 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 862719001029 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 862719001030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719001031 dimer interface [polypeptide binding]; other site 862719001032 conserved gate region; other site 862719001033 putative PBP binding loops; other site 862719001034 ABC-ATPase subunit interface; other site 862719001035 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 862719001036 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 862719001037 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 862719001038 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719001039 active site 862719001040 metal binding site [ion binding]; metal-binding site 862719001041 hexamer interface [polypeptide binding]; other site 862719001042 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719001043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719001044 Walker A/P-loop; other site 862719001045 ATP binding site [chemical binding]; other site 862719001046 Q-loop/lid; other site 862719001047 ABC transporter signature motif; other site 862719001048 Walker B; other site 862719001049 D-loop; other site 862719001050 H-loop/switch region; other site 862719001051 TOBE domain; Region: TOBE_2; pfam08402 862719001052 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719001053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719001054 dimer interface [polypeptide binding]; other site 862719001055 conserved gate region; other site 862719001056 putative PBP binding loops; other site 862719001057 ABC-ATPase subunit interface; other site 862719001058 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 862719001059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719001060 dimer interface [polypeptide binding]; other site 862719001061 conserved gate region; other site 862719001062 putative PBP binding loops; other site 862719001063 ABC-ATPase subunit interface; other site 862719001064 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 862719001065 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 862719001066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 862719001067 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719001068 DNA binding site [nucleotide binding] 862719001069 domain linker motif; other site 862719001070 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862719001071 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 862719001072 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 862719001073 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 862719001074 Secretin and TonB N terminus short domain; Region: STN; smart00965 862719001075 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 862719001076 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719001077 N-terminal plug; other site 862719001078 ligand-binding site [chemical binding]; other site 862719001079 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 862719001080 FecR protein; Region: FecR; pfam04773 862719001081 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 862719001082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719001083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719001084 DNA binding residues [nucleotide binding] 862719001085 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719001086 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 862719001087 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 862719001088 glutaminase active site [active] 862719001089 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 862719001090 dimer interface [polypeptide binding]; other site 862719001091 active site 862719001092 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 862719001093 dimer interface [polypeptide binding]; other site 862719001094 active site 862719001095 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 862719001096 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 862719001097 Substrate binding site; other site 862719001098 Mg++ binding site; other site 862719001099 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 862719001100 active site 862719001101 substrate binding site [chemical binding]; other site 862719001102 CoA binding site [chemical binding]; other site 862719001103 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 862719001104 active site 862719001105 catalytic residues [active] 862719001106 DNA binding site [nucleotide binding] 862719001107 Int/Topo IB signature motif; other site 862719001108 Ribbon-helix-helix domain; Region: RHH_4; cl01775 862719001109 DnaA N-terminal domain; Region: DnaA_N; pfam11638 862719001110 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 862719001111 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719001112 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 862719001113 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 862719001114 mismatch recognition site; other site 862719001115 additional DNA contacts [nucleotide binding]; other site 862719001116 active site 862719001117 zinc binding site [ion binding]; other site 862719001118 DNA intercalation site [nucleotide binding]; other site 862719001119 Uncharacterized conserved protein [Function unknown]; Region: COG1479 862719001120 Protein of unknown function DUF262; Region: DUF262; pfam03235 862719001121 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 862719001122 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 862719001123 cofactor binding site; other site 862719001124 DNA binding site [nucleotide binding] 862719001125 substrate interaction site [chemical binding]; other site 862719001126 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 862719001127 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719001128 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 862719001129 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719001130 active site 862719001131 Int/Topo IB signature motif; other site 862719001132 DNA binding site [nucleotide binding] 862719001133 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 862719001134 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 862719001135 DNA methylase; Region: N6_N4_Mtase; cl17433 862719001136 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 862719001137 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 862719001138 gpW; Region: gpW; pfam02831 862719001139 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 862719001140 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 862719001141 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin 862719001142 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 862719001143 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 862719001144 SPRY domain-like in bacteria; Region: SPRY_like; cd12886 862719001145 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 862719001146 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 862719001147 catalytic residue [active] 862719001148 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 862719001149 pantoate--beta-alanine ligase; Region: panC; TIGR00018 862719001150 Pantoate-beta-alanine ligase; Region: PanC; cd00560 862719001151 active site 862719001152 ATP-binding site [chemical binding]; other site 862719001153 pantoate-binding site; other site 862719001154 HXXH motif; other site 862719001155 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 862719001156 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 862719001157 muropeptide transporter; Validated; Region: ampG; cl17669 862719001158 muropeptide transporter; Reviewed; Region: ampG; PRK11902 862719001159 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 862719001160 dimanganese center [ion binding]; other site 862719001161 glutathione reductase; Validated; Region: PRK06116 862719001162 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862719001163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719001164 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862719001165 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 862719001166 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 862719001167 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 862719001168 active site 862719001169 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 862719001170 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 862719001171 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 862719001172 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 862719001173 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 862719001174 intersubunit interface [polypeptide binding]; other site 862719001175 active site 862719001176 catalytic residue [active] 862719001177 purine nucleoside phosphorylase; Provisional; Region: PRK08202 862719001178 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 862719001179 active site 862719001180 catalytic motif [active] 862719001181 Zn binding site [ion binding]; other site 862719001182 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719001183 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719001184 TM-ABC transporter signature motif; other site 862719001185 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719001186 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719001187 TM-ABC transporter signature motif; other site 862719001188 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 862719001189 dimer interface [polypeptide binding]; other site 862719001190 [2Fe-2S] cluster binding site [ion binding]; other site 862719001191 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 862719001192 EamA-like transporter family; Region: EamA; pfam00892 862719001193 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 862719001194 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 862719001195 ligand binding site [chemical binding]; other site 862719001196 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719001197 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719001198 TM-ABC transporter signature motif; other site 862719001199 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719001200 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719001201 TM-ABC transporter signature motif; other site 862719001202 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719001203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719001204 Walker A/P-loop; other site 862719001205 ATP binding site [chemical binding]; other site 862719001206 Q-loop/lid; other site 862719001207 ABC transporter signature motif; other site 862719001208 Walker B; other site 862719001209 D-loop; other site 862719001210 H-loop/switch region; other site 862719001211 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719001212 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719001213 Walker A/P-loop; other site 862719001214 ATP binding site [chemical binding]; other site 862719001215 Q-loop/lid; other site 862719001216 ABC transporter signature motif; other site 862719001217 Walker B; other site 862719001218 D-loop; other site 862719001219 H-loop/switch region; other site 862719001220 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719001221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719001222 dimer interface [polypeptide binding]; other site 862719001223 conserved gate region; other site 862719001224 putative PBP binding loops; other site 862719001225 ABC-ATPase subunit interface; other site 862719001226 NMT1/THI5 like; Region: NMT1; pfam09084 862719001227 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719001228 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 862719001229 Walker A/P-loop; other site 862719001230 ATP binding site [chemical binding]; other site 862719001231 Q-loop/lid; other site 862719001232 ABC transporter signature motif; other site 862719001233 Walker B; other site 862719001234 D-loop; other site 862719001235 H-loop/switch region; other site 862719001236 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 862719001237 metal binding site [ion binding]; metal-binding site 862719001238 substrate binding pocket [chemical binding]; other site 862719001239 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719001240 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 862719001241 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 862719001242 Protein of unknown function (DUF993); Region: DUF993; pfam06187 862719001243 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 862719001244 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 862719001245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719001246 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719001247 Ligand Binding Site [chemical binding]; other site 862719001248 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719001249 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719001250 active site 862719001251 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 862719001252 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 862719001253 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 862719001254 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719001255 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719001256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719001257 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 862719001258 substrate binding site [chemical binding]; other site 862719001259 oxyanion hole (OAH) forming residues; other site 862719001260 trimer interface [polypeptide binding]; other site 862719001261 acyl-CoA synthetase; Validated; Region: PRK08316 862719001262 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719001263 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 862719001264 acyl-activating enzyme (AAE) consensus motif; other site 862719001265 acyl-activating enzyme (AAE) consensus motif; other site 862719001266 putative AMP binding site [chemical binding]; other site 862719001267 putative active site [active] 862719001268 putative CoA binding site [chemical binding]; other site 862719001269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719001270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719001271 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 862719001272 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719001273 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 862719001274 putative ligand binding site [chemical binding]; other site 862719001275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719001276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719001277 short chain dehydrogenase; Provisional; Region: PRK06949 862719001278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719001279 NAD(P) binding site [chemical binding]; other site 862719001280 active site 862719001281 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719001282 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719001283 active site 862719001284 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 862719001285 putative active site [active] 862719001286 putative substrate binding site [chemical binding]; other site 862719001287 ATP binding site [chemical binding]; other site 862719001288 Phosphotransferase enzyme family; Region: APH; pfam01636 862719001289 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719001290 catalytic core [active] 862719001291 pyruvate kinase; Provisional; Region: PRK06247 862719001292 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 862719001293 domain interfaces; other site 862719001294 active site 862719001295 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 862719001296 active site 862719001297 catalytic residues [active] 862719001298 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 862719001299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719001300 motif II; other site 862719001301 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 862719001302 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 862719001303 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 862719001304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719001305 dimer interface [polypeptide binding]; other site 862719001306 conserved gate region; other site 862719001307 putative PBP binding loops; other site 862719001308 ABC-ATPase subunit interface; other site 862719001309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719001310 dimer interface [polypeptide binding]; other site 862719001311 conserved gate region; other site 862719001312 putative PBP binding loops; other site 862719001313 ABC-ATPase subunit interface; other site 862719001314 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 862719001315 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 862719001316 Walker A/P-loop; other site 862719001317 ATP binding site [chemical binding]; other site 862719001318 Q-loop/lid; other site 862719001319 ABC transporter signature motif; other site 862719001320 Walker B; other site 862719001321 D-loop; other site 862719001322 H-loop/switch region; other site 862719001323 putative cation:proton antiport protein; Provisional; Region: PRK10669 862719001324 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 862719001325 TrkA-N domain; Region: TrkA_N; pfam02254 862719001326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 862719001327 NAD synthetase; Reviewed; Region: nadE; PRK00876 862719001328 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719001329 Ligand Binding Site [chemical binding]; other site 862719001330 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 862719001331 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 862719001332 active site 862719001333 dimer interface [polypeptide binding]; other site 862719001334 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 862719001335 Ligand Binding Site [chemical binding]; other site 862719001336 Molecular Tunnel; other site 862719001337 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 862719001338 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719001339 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719001340 acyl-activating enzyme (AAE) consensus motif; other site 862719001341 AMP binding site [chemical binding]; other site 862719001342 active site 862719001343 CoA binding site [chemical binding]; other site 862719001344 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 862719001345 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 862719001346 putative active site [active] 862719001347 putative metal binding site [ion binding]; other site 862719001348 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719001349 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719001350 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719001351 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719001352 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 862719001353 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719001354 active site 862719001355 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 862719001356 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 862719001357 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 862719001358 Bacterial sugar transferase; Region: Bac_transf; pfam02397 862719001359 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 862719001360 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 862719001361 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 862719001362 trimer interface [polypeptide binding]; other site 862719001363 active site 862719001364 substrate binding site [chemical binding]; other site 862719001365 CoA binding site [chemical binding]; other site 862719001366 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 862719001367 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 862719001368 Calx-beta domain; Region: Calx-beta; pfam03160 862719001369 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719001370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719001371 S-adenosylmethionine binding site [chemical binding]; other site 862719001372 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 862719001373 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 862719001374 Chain length determinant protein; Region: Wzz; pfam02706 862719001375 Chain length determinant protein; Region: Wzz; cl15801 862719001376 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 862719001377 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 862719001378 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 862719001379 DEAD/DEAH box helicase; Region: DEAD; pfam00270 862719001380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719001381 nucleotide binding region [chemical binding]; other site 862719001382 ATP-binding site [chemical binding]; other site 862719001383 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 862719001384 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719001385 catalytic core [active] 862719001386 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719001387 Helix-turn-helix domain; Region: HTH_36; pfam13730 862719001388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719001389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719001390 dimer interface [polypeptide binding]; other site 862719001391 phosphorylation site [posttranslational modification] 862719001392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719001393 ATP binding site [chemical binding]; other site 862719001394 Mg2+ binding site [ion binding]; other site 862719001395 G-X-G motif; other site 862719001396 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719001397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719001398 active site 862719001399 phosphorylation site [posttranslational modification] 862719001400 intermolecular recognition site; other site 862719001401 dimerization interface [polypeptide binding]; other site 862719001402 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 862719001403 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719001404 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719001405 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719001406 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719001407 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719001408 pseudaminic acid synthase; Region: PseI; TIGR03586 862719001409 NeuB family; Region: NeuB; pfam03102 862719001410 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 862719001411 NeuB binding interface [polypeptide binding]; other site 862719001412 putative substrate binding site [chemical binding]; other site 862719001413 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 862719001414 ligand binding site; other site 862719001415 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 862719001416 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 862719001417 nucleophilic elbow; other site 862719001418 catalytic triad; other site 862719001419 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719001420 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 862719001421 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719001422 active site 862719001423 AMP binding site [chemical binding]; other site 862719001424 acyl-activating enzyme (AAE) consensus motif; other site 862719001425 CoA binding site [chemical binding]; other site 862719001426 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 862719001427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719001428 NAD(P) binding site [chemical binding]; other site 862719001429 active site 862719001430 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 862719001431 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 862719001432 dimer interface [polypeptide binding]; other site 862719001433 active site 862719001434 CoA binding pocket [chemical binding]; other site 862719001435 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719001436 Flagellar protein FlbT; Region: FlbT; cl11455 862719001437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001438 binding surface 862719001439 TPR motif; other site 862719001440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001441 binding surface 862719001442 TPR motif; other site 862719001443 TPR repeat; Region: TPR_11; pfam13414 862719001444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001445 binding surface 862719001446 TPR motif; other site 862719001447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001448 binding surface 862719001449 TPR motif; other site 862719001450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001451 TPR motif; other site 862719001452 binding surface 862719001453 TPR repeat; Region: TPR_11; pfam13414 862719001454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001455 binding surface 862719001456 TPR motif; other site 862719001457 TPR repeat; Region: TPR_11; pfam13414 862719001458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001459 binding surface 862719001460 TPR repeat; Region: TPR_11; pfam13414 862719001461 TPR motif; other site 862719001462 Protein of unknown function (DUF465); Region: DUF465; cl01070 862719001463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001464 binding surface 862719001465 TPR motif; other site 862719001466 TPR repeat; Region: TPR_11; pfam13414 862719001467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 862719001468 binding surface 862719001469 TPR motif; other site 862719001470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001471 binding surface 862719001472 TPR motif; other site 862719001473 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 862719001474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001475 binding surface 862719001476 TPR motif; other site 862719001477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001478 binding surface 862719001479 TPR motif; other site 862719001480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001481 TPR motif; other site 862719001482 TPR repeat; Region: TPR_11; pfam13414 862719001483 binding surface 862719001484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001485 binding surface 862719001486 TPR motif; other site 862719001487 TPR repeat; Region: TPR_11; pfam13414 862719001488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001489 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719001490 binding surface 862719001491 TPR motif; other site 862719001492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001493 binding surface 862719001494 TPR motif; other site 862719001495 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719001496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719001497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001498 TPR motif; other site 862719001499 binding surface 862719001500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001501 binding surface 862719001502 TPR motif; other site 862719001503 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 862719001504 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862719001505 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 862719001506 Protein phosphatase 2C; Region: PP2C; pfam00481 862719001507 active site 862719001508 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 862719001509 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 862719001510 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 862719001511 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 862719001512 active site 862719001513 catalytic site [active] 862719001514 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 862719001515 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719001516 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719001517 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862719001518 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 862719001519 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862719001520 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 862719001521 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 862719001522 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719001523 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862719001524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001525 TPR motif; other site 862719001526 TPR repeat; Region: TPR_11; pfam13414 862719001527 binding surface 862719001528 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 862719001529 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 862719001530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719001531 putative active site [active] 862719001532 heme pocket [chemical binding]; other site 862719001533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719001534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719001535 ATP binding site [chemical binding]; other site 862719001536 Mg2+ binding site [ion binding]; other site 862719001537 G-X-G motif; other site 862719001538 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862719001539 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 862719001540 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 862719001541 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719001542 active site 862719001543 metal binding site [ion binding]; metal-binding site 862719001544 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 862719001545 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 862719001546 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 862719001547 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 862719001548 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 862719001549 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 862719001550 C-terminal domain interface [polypeptide binding]; other site 862719001551 GSH binding site (G-site) [chemical binding]; other site 862719001552 dimer interface [polypeptide binding]; other site 862719001553 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 862719001554 N-terminal domain interface [polypeptide binding]; other site 862719001555 putative dimer interface [polypeptide binding]; other site 862719001556 active site 862719001557 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719001558 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719001559 active site 862719001560 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 862719001561 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719001562 acyl-activating enzyme (AAE) consensus motif; other site 862719001563 AMP binding site [chemical binding]; other site 862719001564 active site 862719001565 CoA binding site [chemical binding]; other site 862719001566 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 862719001567 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862719001568 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719001569 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719001570 TM-ABC transporter signature motif; other site 862719001571 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719001572 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719001573 TM-ABC transporter signature motif; other site 862719001574 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719001575 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719001576 Walker A/P-loop; other site 862719001577 ATP binding site [chemical binding]; other site 862719001578 Q-loop/lid; other site 862719001579 ABC transporter signature motif; other site 862719001580 Walker B; other site 862719001581 D-loop; other site 862719001582 H-loop/switch region; other site 862719001583 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719001584 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719001585 Walker A/P-loop; other site 862719001586 ATP binding site [chemical binding]; other site 862719001587 Q-loop/lid; other site 862719001588 ABC transporter signature motif; other site 862719001589 Walker B; other site 862719001590 D-loop; other site 862719001591 H-loop/switch region; other site 862719001592 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 862719001593 CoenzymeA binding site [chemical binding]; other site 862719001594 subunit interaction site [polypeptide binding]; other site 862719001595 PHB binding site; other site 862719001596 enoyl-CoA hydratase; Provisional; Region: PRK07511 862719001597 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719001598 substrate binding site [chemical binding]; other site 862719001599 oxyanion hole (OAH) forming residues; other site 862719001600 trimer interface [polypeptide binding]; other site 862719001601 Response regulator receiver domain; Region: Response_reg; pfam00072 862719001602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719001603 active site 862719001604 phosphorylation site [posttranslational modification] 862719001605 intermolecular recognition site; other site 862719001606 dimerization interface [polypeptide binding]; other site 862719001607 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 862719001608 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 862719001609 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 862719001610 active site 862719001611 catalytic site [active] 862719001612 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 862719001613 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 862719001614 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 862719001615 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 862719001616 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 862719001617 catalytic site [active] 862719001618 active site 862719001619 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 862719001620 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 862719001621 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 862719001622 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719001623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719001624 active site 862719001625 phosphorylation site [posttranslational modification] 862719001626 intermolecular recognition site; other site 862719001627 dimerization interface [polypeptide binding]; other site 862719001628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719001629 Walker A motif; other site 862719001630 ATP binding site [chemical binding]; other site 862719001631 Walker B motif; other site 862719001632 arginine finger; other site 862719001633 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719001634 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 862719001635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719001636 dimer interface [polypeptide binding]; other site 862719001637 phosphorylation site [posttranslational modification] 862719001638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719001639 ATP binding site [chemical binding]; other site 862719001640 Mg2+ binding site [ion binding]; other site 862719001641 G-X-G motif; other site 862719001642 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 862719001643 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 862719001644 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 862719001645 Malic enzyme, N-terminal domain; Region: malic; pfam00390 862719001646 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 862719001647 putative NAD(P) binding site [chemical binding]; other site 862719001648 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 862719001649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001650 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719001651 TPR motif; other site 862719001652 binding surface 862719001653 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719001654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001655 binding surface 862719001656 TPR motif; other site 862719001657 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 862719001658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001659 TPR motif; other site 862719001660 binding surface 862719001661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001662 binding surface 862719001663 TPR motif; other site 862719001664 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719001665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001666 binding surface 862719001667 TPR motif; other site 862719001668 TPR repeat; Region: TPR_11; pfam13414 862719001669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001670 binding surface 862719001671 TPR motif; other site 862719001672 TPR repeat; Region: TPR_11; pfam13414 862719001673 TPR repeat; Region: TPR_11; pfam13414 862719001674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001675 binding surface 862719001676 TPR motif; other site 862719001677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001678 binding surface 862719001679 TPR motif; other site 862719001680 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 862719001681 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 862719001682 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 862719001683 Substrate binding site; other site 862719001684 Mg++ binding site; other site 862719001685 metal-binding site 862719001686 Mg++ binding site; other site 862719001687 metal-binding site 862719001688 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 862719001689 Glycosyltransferase family 28 N-terminal domain; Region: Glyco_transf_28; pfam03033 862719001690 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 862719001691 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 862719001692 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 862719001693 active site 862719001694 acyl-activating enzyme (AAE) consensus motif; other site 862719001695 putative CoA binding site [chemical binding]; other site 862719001696 AMP binding site [chemical binding]; other site 862719001697 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862719001698 hypothetical protein; Provisional; Region: PRK10621 862719001699 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719001700 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719001701 Walker A/P-loop; other site 862719001702 ATP binding site [chemical binding]; other site 862719001703 Q-loop/lid; other site 862719001704 ABC transporter signature motif; other site 862719001705 Walker B; other site 862719001706 D-loop; other site 862719001707 H-loop/switch region; other site 862719001708 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719001709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719001710 TPR motif; other site 862719001711 binding surface 862719001712 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719001713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 862719001714 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 862719001715 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719001716 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719001717 TM-ABC transporter signature motif; other site 862719001718 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719001719 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719001720 TM-ABC transporter signature motif; other site 862719001721 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719001722 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719001723 Walker A/P-loop; other site 862719001724 ATP binding site [chemical binding]; other site 862719001725 Q-loop/lid; other site 862719001726 ABC transporter signature motif; other site 862719001727 Walker B; other site 862719001728 D-loop; other site 862719001729 H-loop/switch region; other site 862719001730 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 862719001731 active site 862719001732 catalytic residues [active] 862719001733 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 862719001734 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719001735 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719001736 metal binding site [ion binding]; metal-binding site 862719001737 active site 862719001738 I-site; other site 862719001739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719001740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719001741 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719001742 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 862719001743 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719001744 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719001745 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 862719001746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719001747 putative substrate translocation pore; other site 862719001748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719001749 homoserine O-acetyltransferase; Provisional; Region: PRK06765 862719001750 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 862719001751 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 862719001752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 862719001753 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 862719001754 LysE type translocator; Region: LysE; cl00565 862719001755 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 862719001756 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 862719001757 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 862719001758 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 862719001759 RNA binding site [nucleotide binding]; other site 862719001760 Heavy-metal resistance; Region: Metal_resist; pfam13801 862719001761 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 862719001762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719001763 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 862719001764 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 862719001765 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 862719001766 homodimer interface [polypeptide binding]; other site 862719001767 metal binding site [ion binding]; metal-binding site 862719001768 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 862719001769 homodimer interface [polypeptide binding]; other site 862719001770 active site 862719001771 putative chemical substrate binding site [chemical binding]; other site 862719001772 metal binding site [ion binding]; metal-binding site 862719001773 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 862719001774 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 862719001775 DXD motif; other site 862719001776 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 862719001777 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 862719001778 putative acyl-acceptor binding pocket; other site 862719001779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862719001780 phytoene desaturase; Region: crtI_fam; TIGR02734 862719001781 phytoene desaturase; Region: crtI_fam; TIGR02734 862719001782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862719001783 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 862719001784 NAD(P) binding site [chemical binding]; other site 862719001785 catalytic residues [active] 862719001786 Predicted membrane protein [Function unknown]; Region: COG3918 862719001787 beta-ketothiolase; Provisional; Region: PRK09051 862719001788 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719001789 dimer interface [polypeptide binding]; other site 862719001790 active site 862719001791 enoyl-CoA hydratase; Provisional; Region: PRK06688 862719001792 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719001793 substrate binding site [chemical binding]; other site 862719001794 oxyanion hole (OAH) forming residues; other site 862719001795 trimer interface [polypeptide binding]; other site 862719001796 putative MFS family transporter protein; Provisional; Region: PRK03633 862719001797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719001798 putative substrate translocation pore; other site 862719001799 Predicted acetyltransferase [General function prediction only]; Region: COG2388 862719001800 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719001801 classical (c) SDRs; Region: SDR_c; cd05233 862719001802 NAD(P) binding site [chemical binding]; other site 862719001803 active site 862719001804 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 862719001805 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 862719001806 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 862719001807 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 862719001808 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 862719001809 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 862719001810 trimer interface I [polypeptide binding]; other site 862719001811 putative substrate binding pocket [chemical binding]; other site 862719001812 trimer interface II [polypeptide binding]; other site 862719001813 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 862719001814 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 862719001815 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 862719001816 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 862719001817 molybdopterin cofactor binding site; other site 862719001818 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 862719001819 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719001820 active site 862719001821 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 862719001822 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 862719001823 FTR, proximal lobe; Region: FTR_C; pfam02741 862719001824 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 862719001825 domain_subunit interface; other site 862719001826 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 862719001827 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719001828 ligand binding site [chemical binding]; other site 862719001829 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 862719001830 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719001831 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719001832 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719001833 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 862719001834 PqqA family; Region: PqqA; cl15372 862719001835 RibD C-terminal domain; Region: RibD_C; cl17279 862719001836 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 862719001837 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 862719001838 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719001839 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719001840 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 862719001841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719001842 Walker A/P-loop; other site 862719001843 ATP binding site [chemical binding]; other site 862719001844 Q-loop/lid; other site 862719001845 ABC transporter signature motif; other site 862719001846 Walker B; other site 862719001847 D-loop; other site 862719001848 H-loop/switch region; other site 862719001849 ABC-2 type transporter; Region: ABC2_membrane; cl17235 862719001850 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 862719001851 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 862719001852 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 862719001853 Trp docking motif [polypeptide binding]; other site 862719001854 dimer interface [polypeptide binding]; other site 862719001855 active site 862719001856 small subunit binding site [polypeptide binding]; other site 862719001857 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 862719001858 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 862719001859 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719001860 substrate binding pocket [chemical binding]; other site 862719001861 membrane-bound complex binding site; other site 862719001862 hinge residues; other site 862719001863 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862719001864 active site residue [active] 862719001865 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 862719001866 Dihydroneopterin aldolase; Region: FolB; pfam02152 862719001867 dihydropteroate synthase-related protein; Region: TIGR00284 862719001868 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 862719001869 substrate binding pocket [chemical binding]; other site 862719001870 dimer interface [polypeptide binding]; other site 862719001871 inhibitor binding site; inhibition site 862719001872 Protein of unknown function (DUF447); Region: DUF447; pfam04289 862719001873 hypothetical protein; Provisional; Region: PRK02227 862719001874 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 862719001875 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719001876 catalytic loop [active] 862719001877 iron binding site [ion binding]; other site 862719001878 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862719001879 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 862719001880 [4Fe-4S] binding site [ion binding]; other site 862719001881 molybdopterin cofactor binding site; other site 862719001882 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 862719001883 molybdopterin cofactor binding site; other site 862719001884 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 862719001885 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 862719001886 putative dimer interface [polypeptide binding]; other site 862719001887 [2Fe-2S] cluster binding site [ion binding]; other site 862719001888 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 862719001889 SLBB domain; Region: SLBB; pfam10531 862719001890 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 862719001891 phosphoglycolate phosphatase; Provisional; Region: PRK13222 862719001892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719001893 motif II; other site 862719001894 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 862719001895 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 862719001896 intersubunit interface [polypeptide binding]; other site 862719001897 active site 862719001898 zinc binding site [ion binding]; other site 862719001899 Na+ binding site [ion binding]; other site 862719001900 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 862719001901 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 862719001902 TPP-binding site [chemical binding]; other site 862719001903 dimer interface [polypeptide binding]; other site 862719001904 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862719001905 PYR/PP interface [polypeptide binding]; other site 862719001906 dimer interface [polypeptide binding]; other site 862719001907 TPP binding site [chemical binding]; other site 862719001908 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719001909 phosphoribulokinase; Provisional; Region: PRK15453 862719001910 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 862719001911 AMP binding site [chemical binding]; other site 862719001912 metal binding site [ion binding]; metal-binding site 862719001913 active site 862719001914 CbbX; Provisional; Region: cbbX; CHL00181 862719001915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719001916 Walker A motif; other site 862719001917 ATP binding site [chemical binding]; other site 862719001918 Walker B motif; other site 862719001919 arginine finger; other site 862719001920 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 862719001921 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 862719001922 substrate binding site [chemical binding]; other site 862719001923 hexamer interface [polypeptide binding]; other site 862719001924 metal binding site [ion binding]; metal-binding site 862719001925 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 862719001926 multimerization interface [polypeptide binding]; other site 862719001927 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 862719001928 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 862719001929 homodimer interface [polypeptide binding]; other site 862719001930 active site 862719001931 heterodimer interface [polypeptide binding]; other site 862719001932 catalytic residue [active] 862719001933 metal binding site [ion binding]; metal-binding site 862719001934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719001935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719001936 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 862719001937 putative dimerization interface [polypeptide binding]; other site 862719001938 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 862719001939 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 862719001940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719001941 Walker A motif; other site 862719001942 ATP binding site [chemical binding]; other site 862719001943 Walker B motif; other site 862719001944 arginine finger; other site 862719001945 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719001946 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 862719001947 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 862719001948 ring oligomerisation interface [polypeptide binding]; other site 862719001949 ATP/Mg binding site [chemical binding]; other site 862719001950 stacking interactions; other site 862719001951 hinge regions; other site 862719001952 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 862719001953 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 862719001954 dimerization interface [polypeptide binding]; other site 862719001955 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 862719001956 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719001957 catalytic loop [active] 862719001958 iron binding site [ion binding]; other site 862719001959 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 862719001960 FAD binding pocket [chemical binding]; other site 862719001961 FAD binding motif [chemical binding]; other site 862719001962 phosphate binding motif [ion binding]; other site 862719001963 beta-alpha-beta structure motif; other site 862719001964 NAD binding pocket [chemical binding]; other site 862719001965 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 862719001966 dimerization interface [polypeptide binding]; other site 862719001967 putative path to active site cavity [active] 862719001968 diiron center [ion binding]; other site 862719001969 Cytochrome c; Region: Cytochrom_C; cl11414 862719001970 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719001971 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 862719001972 dimer interface [polypeptide binding]; other site 862719001973 active site 862719001974 metal binding site [ion binding]; metal-binding site 862719001975 glutathione binding site [chemical binding]; other site 862719001976 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 862719001977 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 862719001978 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 862719001979 exonuclease subunit SbcD; Provisional; Region: PRK10966 862719001980 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 862719001981 active site 862719001982 metal binding site [ion binding]; metal-binding site 862719001983 DNA binding site [nucleotide binding] 862719001984 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 862719001985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719001986 Walker A/P-loop; other site 862719001987 ATP binding site [chemical binding]; other site 862719001988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862719001989 Q-loop/lid; other site 862719001990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719001991 Q-loop/lid; other site 862719001992 ABC transporter signature motif; other site 862719001993 Walker B; other site 862719001994 D-loop; other site 862719001995 H-loop/switch region; other site 862719001996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719001997 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862719001998 Walker A motif; other site 862719001999 ATP binding site [chemical binding]; other site 862719002000 Walker B motif; other site 862719002001 arginine finger; other site 862719002002 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719002003 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 862719002004 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 862719002005 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719002006 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 862719002007 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 862719002008 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 862719002009 motif 1; other site 862719002010 active site 862719002011 motif 2; other site 862719002012 motif 3; other site 862719002013 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 862719002014 DHHA1 domain; Region: DHHA1; pfam02272 862719002015 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 862719002016 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 862719002017 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 862719002018 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 862719002019 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 862719002020 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 862719002021 Peptidase family M50; Region: Peptidase_M50; pfam02163 862719002022 active site 862719002023 putative substrate binding region [chemical binding]; other site 862719002024 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 862719002025 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 862719002026 Sporulation related domain; Region: SPOR; pfam05036 862719002027 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 862719002028 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 862719002029 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 862719002030 active site 862719002031 HIGH motif; other site 862719002032 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719002033 KMSK motif region; other site 862719002034 tRNA binding surface [nucleotide binding]; other site 862719002035 DALR anticodon binding domain; Region: DALR_1; smart00836 862719002036 anticodon binding site; other site 862719002037 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 862719002038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719002039 Zn2+ binding site [ion binding]; other site 862719002040 Mg2+ binding site [ion binding]; other site 862719002041 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 862719002042 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 862719002043 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 862719002044 putative catalytic site [active] 862719002045 putative phosphate binding site [ion binding]; other site 862719002046 active site 862719002047 metal binding site A [ion binding]; metal-binding site 862719002048 DNA binding site [nucleotide binding] 862719002049 putative AP binding site [nucleotide binding]; other site 862719002050 putative metal binding site B [ion binding]; other site 862719002051 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 862719002052 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 862719002053 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 862719002054 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 862719002055 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 862719002056 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 862719002057 CSL zinc finger; Region: zf-CSL; cl02163 862719002058 Helix-turn-helix domain; Region: HTH_17; cl17695 862719002059 integrase; Provisional; Region: PRK09692 862719002060 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 862719002061 active site 862719002062 Int/Topo IB signature motif; other site 862719002063 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 862719002064 aminopeptidase N; Provisional; Region: pepN; PRK14015 862719002065 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 862719002066 active site 862719002067 Zn binding site [ion binding]; other site 862719002068 Cytochrome c2 [Energy production and conversion]; Region: COG3474 862719002069 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 862719002070 putative hydrophobic ligand binding site [chemical binding]; other site 862719002071 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 862719002072 catalytic center binding site [active] 862719002073 ATP binding site [chemical binding]; other site 862719002074 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 862719002075 Response regulator receiver domain; Region: Response_reg; pfam00072 862719002076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719002077 active site 862719002078 phosphorylation site [posttranslational modification] 862719002079 intermolecular recognition site; other site 862719002080 dimerization interface [polypeptide binding]; other site 862719002081 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862719002082 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719002083 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719002084 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719002085 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719002086 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 862719002087 active site 862719002088 Clp protease; Region: CLP_protease; pfam00574 862719002089 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 862719002090 oligomer interface [polypeptide binding]; other site 862719002091 active site residues [active] 862719002092 OpgC protein; Region: OpgC_C; cl17858 862719002093 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 862719002094 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 862719002095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719002096 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 862719002097 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 862719002098 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719002099 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719002100 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719002101 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 862719002102 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 862719002103 Cytochrome c553 [Energy production and conversion]; Region: COG2863 862719002104 Cytochrome c; Region: Cytochrom_C; cl11414 862719002105 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 862719002106 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 862719002107 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 862719002108 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 862719002109 D-pathway; other site 862719002110 Low-spin heme binding site [chemical binding]; other site 862719002111 Putative water exit pathway; other site 862719002112 Binuclear center (active site) [active] 862719002113 K-pathway; other site 862719002114 Putative proton exit pathway; other site 862719002115 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 862719002116 Subunit I/III interface [polypeptide binding]; other site 862719002117 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 862719002118 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 862719002119 Cytochrome c; Region: Cytochrom_C; pfam00034 862719002120 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 862719002121 TIGR02588 family protein; Region: TIGR02588 862719002122 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719002123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719002124 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 862719002125 putative effector binding pocket; other site 862719002126 putative dimerization interface [polypeptide binding]; other site 862719002127 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719002128 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719002129 ligand binding site [chemical binding]; other site 862719002130 flexible hinge region; other site 862719002131 CAAX protease self-immunity; Region: Abi; pfam02517 862719002132 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 862719002133 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 862719002134 active site 862719002135 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 862719002136 active site 862719002137 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 862719002138 Acyl transferase domain; Region: Acyl_transf_1; cl08282 862719002139 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 862719002140 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 862719002141 active site 2 [active] 862719002142 active site 1 [active] 862719002143 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 862719002144 active site 2 [active] 862719002145 active site 1 [active] 862719002146 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 862719002147 active site 2 [active] 862719002148 active site 1 [active] 862719002149 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 862719002150 active site 2 [active] 862719002151 active site 1 [active] 862719002152 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 862719002153 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 862719002154 putative acyl-acceptor binding pocket; other site 862719002155 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 862719002156 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 862719002157 active site 862719002158 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 862719002159 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 862719002160 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 862719002161 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 862719002162 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 862719002163 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 862719002164 putative NADP binding site [chemical binding]; other site 862719002165 active site 862719002166 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 862719002167 phosphate binding site [ion binding]; other site 862719002168 Beta-lactamase; Region: Beta-lactamase; pfam00144 862719002169 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 862719002170 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 862719002171 Protein of unknown function (DUF533); Region: DUF533; pfam04391 862719002172 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 862719002173 putative metal binding site [ion binding]; other site 862719002174 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 862719002175 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 862719002176 Cl- selectivity filter; other site 862719002177 Cl- binding residues [ion binding]; other site 862719002178 pore gating glutamate residue; other site 862719002179 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719002180 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719002181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719002182 LysR substrate binding domain; Region: LysR_substrate; pfam03466 862719002183 dimerization interface [polypeptide binding]; other site 862719002184 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 862719002185 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719002186 inhibitor-cofactor binding pocket; inhibition site 862719002187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719002188 catalytic residue [active] 862719002189 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 862719002190 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 862719002191 tetrameric interface [polypeptide binding]; other site 862719002192 NAD binding site [chemical binding]; other site 862719002193 catalytic residues [active] 862719002194 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 862719002195 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 862719002196 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 862719002197 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 862719002198 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 862719002199 dimer interface [polypeptide binding]; other site 862719002200 active site 862719002201 glycine-pyridoxal phosphate binding site [chemical binding]; other site 862719002202 folate binding site [chemical binding]; other site 862719002203 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 862719002204 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 862719002205 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 862719002206 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 862719002207 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 862719002208 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 862719002209 hydroxyglutarate oxidase; Provisional; Region: PRK11728 862719002210 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 862719002211 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 862719002212 conserved cys residue [active] 862719002213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002214 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 862719002215 putative deacylase active site [active] 862719002216 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 862719002217 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 862719002218 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 862719002219 putative active site [active] 862719002220 putative substrate binding site [chemical binding]; other site 862719002221 putative cosubstrate binding site; other site 862719002222 catalytic site [active] 862719002223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719002224 putative substrate translocation pore; other site 862719002225 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 862719002226 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 862719002227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719002228 Walker A/P-loop; other site 862719002229 ATP binding site [chemical binding]; other site 862719002230 Q-loop/lid; other site 862719002231 ABC transporter signature motif; other site 862719002232 Walker B; other site 862719002233 D-loop; other site 862719002234 H-loop/switch region; other site 862719002235 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719002236 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719002237 dimer interface [polypeptide binding]; other site 862719002238 putative CheW interface [polypeptide binding]; other site 862719002239 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 862719002240 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 862719002241 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 862719002242 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 862719002243 [2Fe-2S] cluster binding site [ion binding]; other site 862719002244 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 862719002245 putative alpha subunit interface [polypeptide binding]; other site 862719002246 putative active site [active] 862719002247 putative substrate binding site [chemical binding]; other site 862719002248 Fe binding site [ion binding]; other site 862719002249 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 862719002250 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 862719002251 FAD binding pocket [chemical binding]; other site 862719002252 FAD binding motif [chemical binding]; other site 862719002253 phosphate binding motif [ion binding]; other site 862719002254 beta-alpha-beta structure motif; other site 862719002255 NAD binding pocket [chemical binding]; other site 862719002256 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719002257 catalytic loop [active] 862719002258 iron binding site [ion binding]; other site 862719002259 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 862719002260 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 862719002261 conserved cys residue [active] 862719002262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002264 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 862719002265 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 862719002266 putative active site [active] 862719002267 putative FMN binding site [chemical binding]; other site 862719002268 putative substrate binding site [chemical binding]; other site 862719002269 putative catalytic residue [active] 862719002270 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 862719002271 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 862719002272 4Fe-4S binding domain; Region: Fer4; cl02805 862719002273 Cysteine-rich domain; Region: CCG; pfam02754 862719002274 Cysteine-rich domain; Region: CCG; pfam02754 862719002275 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 862719002276 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 862719002277 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719002278 Electron transfer flavoprotein domain; Region: ETF; pfam01012 862719002279 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 862719002280 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 862719002281 Walker A/P-loop; other site 862719002282 ATP binding site [chemical binding]; other site 862719002283 Q-loop/lid; other site 862719002284 ABC transporter signature motif; other site 862719002285 Walker B; other site 862719002286 D-loop; other site 862719002287 H-loop/switch region; other site 862719002288 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719002289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719002290 dimer interface [polypeptide binding]; other site 862719002291 conserved gate region; other site 862719002292 putative PBP binding loops; other site 862719002293 ABC-ATPase subunit interface; other site 862719002294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719002295 Coenzyme A binding pocket [chemical binding]; other site 862719002296 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 862719002297 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 862719002298 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 862719002299 transcription elongation factor regulatory protein; Validated; Region: PRK06342 862719002300 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 862719002301 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 862719002302 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 862719002303 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719002304 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 862719002305 phosphate binding site [ion binding]; other site 862719002306 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 862719002307 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 862719002308 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 862719002309 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719002310 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 862719002311 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 862719002312 trimer interface I [polypeptide binding]; other site 862719002313 putative substrate binding pocket [chemical binding]; other site 862719002314 trimer interface II [polypeptide binding]; other site 862719002315 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 862719002316 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719002317 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 862719002318 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 862719002319 NAD(P) binding pocket [chemical binding]; other site 862719002320 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 862719002321 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 862719002322 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 862719002323 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 862719002324 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 862719002325 molybdopterin cofactor binding site; other site 862719002326 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 862719002327 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719002328 active site 862719002329 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 862719002330 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 862719002331 FTR, proximal lobe; Region: FTR_C; pfam02741 862719002332 Formylmethanofuran dehydrogenase subunit C [Energy production and conversion]; Region: FwdC; COG2218 862719002333 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 862719002334 domain_subunit interface; other site 862719002335 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 862719002336 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 862719002337 conserved cys residue [active] 862719002338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002340 Dihydroneopterin aldolase; Region: FolB; smart00905 862719002341 active site 862719002342 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 862719002343 nucleotide binding site [chemical binding]; other site 862719002344 substrate binding site [chemical binding]; other site 862719002345 archaeoflavoprotein AfpA; Region: archaeo_AfpA; TIGR02699 862719002346 Flavoprotein; Region: Flavoprotein; pfam02441 862719002347 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 862719002348 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 862719002349 Protein of unknown function (DUF447); Region: DUF447; pfam04289 862719002350 hypothetical protein; Provisional; Region: PRK02227 862719002351 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 862719002352 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 862719002353 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 862719002354 PAS domain; Region: PAS_9; pfam13426 862719002355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719002356 putative active site [active] 862719002357 heme pocket [chemical binding]; other site 862719002358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719002359 Histidine kinase; Region: HisKA_2; pfam07568 862719002360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719002361 ATP binding site [chemical binding]; other site 862719002362 Mg2+ binding site [ion binding]; other site 862719002363 G-X-G motif; other site 862719002364 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 862719002365 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 862719002366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862719002367 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 862719002368 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 862719002369 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 862719002370 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 862719002371 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 862719002372 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 862719002373 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719002374 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 862719002375 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 862719002376 EamA-like transporter family; Region: EamA; pfam00892 862719002377 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 862719002378 acetylornithine deacetylase; Provisional; Region: PRK07522 862719002379 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 862719002380 metal binding site [ion binding]; metal-binding site 862719002381 putative dimer interface [polypeptide binding]; other site 862719002382 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 862719002383 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 862719002384 putative ligand binding site [chemical binding]; other site 862719002385 NAD binding site [chemical binding]; other site 862719002386 dimerization interface [polypeptide binding]; other site 862719002387 catalytic site [active] 862719002388 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 862719002389 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 862719002390 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862719002391 NAD(P) binding site [chemical binding]; other site 862719002392 catalytic residues [active] 862719002393 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 862719002394 tartrate dehydrogenase; Region: TTC; TIGR02089 862719002395 succinic semialdehyde dehydrogenase; Region: PLN02278 862719002396 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 862719002397 tetramerization interface [polypeptide binding]; other site 862719002398 NAD(P) binding site [chemical binding]; other site 862719002399 catalytic residues [active] 862719002400 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 862719002401 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719002402 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 862719002403 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 862719002404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719002405 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 862719002406 Coenzyme A binding pocket [chemical binding]; other site 862719002407 hypothetical protein; Provisional; Region: PRK05965 862719002408 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719002409 inhibitor-cofactor binding pocket; inhibition site 862719002410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719002411 catalytic residue [active] 862719002412 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 862719002413 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 862719002414 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719002415 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 862719002416 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719002417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719002418 conserved gate region; other site 862719002419 dimer interface [polypeptide binding]; other site 862719002420 putative PBP binding loops; other site 862719002421 ABC-ATPase subunit interface; other site 862719002422 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 862719002423 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 862719002424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719002425 dimer interface [polypeptide binding]; other site 862719002426 conserved gate region; other site 862719002427 ABC-ATPase subunit interface; other site 862719002428 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 862719002429 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719002430 Walker A/P-loop; other site 862719002431 ATP binding site [chemical binding]; other site 862719002432 Q-loop/lid; other site 862719002433 ABC transporter signature motif; other site 862719002434 Walker B; other site 862719002435 D-loop; other site 862719002436 H-loop/switch region; other site 862719002437 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719002438 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719002439 Walker A/P-loop; other site 862719002440 ATP binding site [chemical binding]; other site 862719002441 Q-loop/lid; other site 862719002442 ABC transporter signature motif; other site 862719002443 Walker B; other site 862719002444 D-loop; other site 862719002445 H-loop/switch region; other site 862719002446 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719002447 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719002448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719002449 putative DNA binding site [nucleotide binding]; other site 862719002450 putative Zn2+ binding site [ion binding]; other site 862719002451 AsnC family; Region: AsnC_trans_reg; pfam01037 862719002452 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719002453 hydroxyglutarate oxidase; Provisional; Region: PRK11728 862719002454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719002455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719002456 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 862719002457 putative dimerization interface [polypeptide binding]; other site 862719002458 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 862719002459 PAS domain S-box; Region: sensory_box; TIGR00229 862719002460 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 862719002461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719002462 dimer interface [polypeptide binding]; other site 862719002463 phosphorylation site [posttranslational modification] 862719002464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719002465 ATP binding site [chemical binding]; other site 862719002466 Mg2+ binding site [ion binding]; other site 862719002467 G-X-G motif; other site 862719002468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719002469 active site 862719002470 phosphorylation site [posttranslational modification] 862719002471 intermolecular recognition site; other site 862719002472 dimerization interface [polypeptide binding]; other site 862719002473 Protein of unknown function (DUF808); Region: DUF808; cl01002 862719002474 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719002475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719002476 active site 862719002477 phosphorylation site [posttranslational modification] 862719002478 intermolecular recognition site; other site 862719002479 dimerization interface [polypeptide binding]; other site 862719002480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719002481 DNA binding residues [nucleotide binding] 862719002482 dimerization interface [polypeptide binding]; other site 862719002483 Histidine kinase; Region: HisKA_3; pfam07730 862719002484 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 862719002485 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 862719002486 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 862719002487 Trp docking motif [polypeptide binding]; other site 862719002488 dimer interface [polypeptide binding]; other site 862719002489 active site 862719002490 small subunit binding site [polypeptide binding]; other site 862719002491 methanol oxidation system protein MoxJ; Region: ABC_MoxJ; TIGR03870 862719002492 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719002493 substrate binding pocket [chemical binding]; other site 862719002494 membrane-bound complex binding site; other site 862719002495 cytochrome c(L), periplasmic; Region: cytochrome_MoxG; TIGR03872 862719002496 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 862719002497 MoxR-like ATPases [General function prediction only]; Region: COG0714 862719002498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719002499 Walker A motif; other site 862719002500 ATP binding site [chemical binding]; other site 862719002501 Walker B motif; other site 862719002502 arginine finger; other site 862719002503 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 862719002504 metal ion-dependent adhesion site (MIDAS); other site 862719002505 von Willebrand factor type A domain; Region: VWA_2; pfam13519 862719002506 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 862719002507 putative hydrophobic ligand binding site [chemical binding]; other site 862719002508 protein interface [polypeptide binding]; other site 862719002509 gate; other site 862719002510 ornithine cyclodeaminase; Validated; Region: PRK06199 862719002511 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 862719002512 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 862719002513 homotrimer interaction site [polypeptide binding]; other site 862719002514 putative active site [active] 862719002515 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719002516 Helix-turn-helix domain; Region: HTH_18; pfam12833 862719002517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002518 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 862719002519 Amidase; Region: Amidase; pfam01425 862719002520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719002521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719002522 putative substrate translocation pore; other site 862719002523 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 862719002524 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 862719002525 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 862719002526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002527 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 862719002528 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 862719002529 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 862719002530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002531 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719002532 PAS domain; Region: PAS_9; pfam13426 862719002533 putative active site [active] 862719002534 heme pocket [chemical binding]; other site 862719002535 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719002536 dimer interface [polypeptide binding]; other site 862719002537 putative CheW interface [polypeptide binding]; other site 862719002538 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 862719002539 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862719002540 NAD(P) binding site [chemical binding]; other site 862719002541 catalytic residues [active] 862719002542 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 862719002543 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 862719002544 dimer interface [polypeptide binding]; other site 862719002545 active site 862719002546 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 862719002547 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 862719002548 active site 862719002549 dimer interface [polypeptide binding]; other site 862719002550 metal binding site [ion binding]; metal-binding site 862719002551 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 862719002552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719002553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719002554 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719002555 putative effector binding pocket; other site 862719002556 dimerization interface [polypeptide binding]; other site 862719002557 SnoaL-like domain; Region: SnoaL_4; pfam13577 862719002558 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 862719002559 Amidase; Region: Amidase; cl11426 862719002560 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719002561 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719002562 active site 862719002563 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 862719002564 [2Fe-2S] cluster binding site [ion binding]; other site 862719002565 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 862719002566 putative alpha subunit interface [polypeptide binding]; other site 862719002567 putative active site [active] 862719002568 putative substrate binding site [chemical binding]; other site 862719002569 Fe binding site [ion binding]; other site 862719002570 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 862719002571 inter-subunit interface; other site 862719002572 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 862719002573 classical (c) SDRs; Region: SDR_c; cd05233 862719002574 NAD(P) binding site [chemical binding]; other site 862719002575 active site 862719002576 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 862719002577 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 862719002578 FMN-binding pocket [chemical binding]; other site 862719002579 flavin binding motif; other site 862719002580 phosphate binding motif [ion binding]; other site 862719002581 beta-alpha-beta structure motif; other site 862719002582 NAD binding pocket [chemical binding]; other site 862719002583 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719002584 catalytic loop [active] 862719002585 iron binding site [ion binding]; other site 862719002586 Flavin Reductases; Region: FlaRed; cl00801 862719002587 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719002588 MarR family; Region: MarR_2; pfam12802 862719002589 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 862719002590 Hemerythrin family; Region: Hemerythrin-like; cl15774 862719002591 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719002592 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719002593 Walker A/P-loop; other site 862719002594 ATP binding site [chemical binding]; other site 862719002595 Q-loop/lid; other site 862719002596 ABC transporter signature motif; other site 862719002597 Walker B; other site 862719002598 D-loop; other site 862719002599 H-loop/switch region; other site 862719002600 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719002601 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719002602 Walker A/P-loop; other site 862719002603 ATP binding site [chemical binding]; other site 862719002604 Q-loop/lid; other site 862719002605 ABC transporter signature motif; other site 862719002606 Walker B; other site 862719002607 D-loop; other site 862719002608 H-loop/switch region; other site 862719002609 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719002610 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719002611 TM-ABC transporter signature motif; other site 862719002612 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719002613 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719002614 TM-ABC transporter signature motif; other site 862719002615 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 862719002616 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 862719002617 putative ligand binding site [chemical binding]; other site 862719002618 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 862719002619 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 862719002620 metal binding site [ion binding]; metal-binding site 862719002621 substrate binding pocket [chemical binding]; other site 862719002622 Muconolactone delta-isomerase; Region: MIase; cl01992 862719002623 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 862719002624 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 862719002625 dimer interface [polypeptide binding]; other site 862719002626 active site 862719002627 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 862719002628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719002629 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719002630 dimerization interface [polypeptide binding]; other site 862719002631 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719002632 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 862719002633 ligand binding site [chemical binding]; other site 862719002634 flexible hinge region; other site 862719002635 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 862719002636 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 862719002637 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 862719002638 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719002639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719002640 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 862719002641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719002642 DNA binding residues [nucleotide binding] 862719002643 dimerization interface [polypeptide binding]; other site 862719002644 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719002645 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002646 Evidence 5 : No homology to any previously reported sequences 862719002647 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 862719002648 iron-sulfur cluster [ion binding]; other site 862719002649 [2Fe-2S] cluster binding site [ion binding]; other site 862719002650 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 862719002651 putative alpha subunit interface [polypeptide binding]; other site 862719002652 putative active site [active] 862719002653 putative substrate binding site [chemical binding]; other site 862719002654 Fe binding site [ion binding]; other site 862719002655 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 862719002656 inter-subunit interface; other site 862719002657 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 862719002658 [2Fe-2S] cluster binding site [ion binding]; other site 862719002659 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 862719002660 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719002661 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719002662 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 862719002663 putative ligand binding site [chemical binding]; other site 862719002664 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719002665 TM-ABC transporter signature motif; other site 862719002666 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719002667 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719002668 TM-ABC transporter signature motif; other site 862719002669 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719002670 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719002671 Walker A/P-loop; other site 862719002672 ATP binding site [chemical binding]; other site 862719002673 Q-loop/lid; other site 862719002674 ABC transporter signature motif; other site 862719002675 Walker B; other site 862719002676 D-loop; other site 862719002677 H-loop/switch region; other site 862719002678 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719002679 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719002680 Walker A/P-loop; other site 862719002681 ATP binding site [chemical binding]; other site 862719002682 Q-loop/lid; other site 862719002683 ABC transporter signature motif; other site 862719002684 Walker B; other site 862719002685 D-loop; other site 862719002686 H-loop/switch region; other site 862719002687 multicopper oxidase; Provisional; Region: PRK10965 862719002688 Integrase core domain; Region: rve; pfam00665 862719002689 transposase; Validated; Region: PRK08181 862719002690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719002691 Walker A motif; other site 862719002692 ATP binding site [chemical binding]; other site 862719002693 Walker B motif; other site 862719002694 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 862719002695 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 862719002696 substrate binding pocket [chemical binding]; other site 862719002697 Helix-turn-helix domain; Region: HTH_18; pfam12833 862719002698 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 862719002699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719002700 putative substrate translocation pore; other site 862719002701 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719002702 Carboxylesterase family; Region: COesterase; pfam00135 862719002703 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 862719002704 substrate binding pocket [chemical binding]; other site 862719002705 catalytic triad [active] 862719002706 LysR family transcriptional regulator; Provisional; Region: PRK14997 862719002707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719002708 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719002709 putative effector binding pocket; other site 862719002710 dimerization interface [polypeptide binding]; other site 862719002711 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002712 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2159625; Product type e : enzyme 862719002713 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002714 FOG: CBS domain [General function prediction only]; Region: COG0517 862719002715 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 862719002716 BON domain; Region: BON; pfam04972 862719002717 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 862719002718 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719002719 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719002720 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719002721 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719002722 dimerization interface [polypeptide binding]; other site 862719002723 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 862719002724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 862719002725 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862719002726 GAF domain; Region: GAF; pfam01590 862719002727 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719002728 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719002729 active site 862719002730 I-site; other site 862719002731 metal binding site [ion binding]; metal-binding site 862719002732 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719002733 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 862719002734 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 862719002735 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 862719002736 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 862719002737 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 862719002738 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 862719002739 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719002740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719002741 non-specific DNA binding site [nucleotide binding]; other site 862719002742 salt bridge; other site 862719002743 sequence-specific DNA binding site [nucleotide binding]; other site 862719002744 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719002745 active site 862719002746 DNA binding site [nucleotide binding] 862719002747 Int/Topo IB signature motif; other site 862719002748 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002749 transposase; Validated; Region: PRK08181 862719002750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719002751 Walker A motif; other site 862719002752 ATP binding site [chemical binding]; other site 862719002753 Walker B motif; other site 862719002754 Integrase core domain; Region: rve; pfam00665 862719002755 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719002756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719002757 non-specific DNA binding site [nucleotide binding]; other site 862719002758 salt bridge; other site 862719002759 sequence-specific DNA binding site [nucleotide binding]; other site 862719002760 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719002761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719002762 non-specific DNA binding site [nucleotide binding]; other site 862719002763 salt bridge; other site 862719002764 sequence-specific DNA binding site [nucleotide binding]; other site 862719002765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719002766 non-specific DNA binding site [nucleotide binding]; other site 862719002767 salt bridge; other site 862719002768 sequence-specific DNA binding site [nucleotide binding]; other site 862719002769 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719002770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719002771 non-specific DNA binding site [nucleotide binding]; other site 862719002772 salt bridge; other site 862719002773 sequence-specific DNA binding site [nucleotide binding]; other site 862719002774 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 862719002775 Helix-turn-helix domain; Region: HTH_17; pfam12728 862719002776 Replication initiator protein A; Region: RPA; pfam10134 862719002777 ParA-like protein; Provisional; Region: PHA02518 862719002778 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719002779 P-loop; other site 862719002780 Magnesium ion binding site [ion binding]; other site 862719002781 ParA-like protein; Provisional; Region: PHA02518 862719002782 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719002783 P-loop; other site 862719002784 Magnesium ion binding site [ion binding]; other site 862719002785 Evidence 7 : Gene remnant; Product type f : factor 862719002786 Evidence 7 : Gene remnant; PubMedId : 1665997; Product type f : factor 862719002787 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 862719002788 Walker A motif; other site 862719002789 ATP binding site [chemical binding]; other site 862719002790 Walker B motif; other site 862719002791 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 862719002792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719002793 Walker B; other site 862719002794 D-loop; other site 862719002795 H-loop/switch region; other site 862719002796 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 862719002797 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 862719002798 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 862719002799 VirB7 interaction site; other site 862719002800 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 862719002801 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719002802 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719002803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719002804 dimerization interface [polypeptide binding]; other site 862719002805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 862719002806 binding surface 862719002807 TPR motif; other site 862719002808 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719002809 CHAT domain; Region: CHAT; pfam12770 862719002810 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 862719002811 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 862719002812 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 862719002813 putative active site [active] 862719002814 putative NTP binding site [chemical binding]; other site 862719002815 putative nucleic acid binding site [nucleotide binding]; other site 862719002816 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 862719002817 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 862719002818 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 862719002819 SIR2-like domain; Region: SIR2_2; pfam13289 862719002820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719002821 AAA domain; Region: AAA_23; pfam13476 862719002822 Walker A/P-loop; other site 862719002823 ATP binding site [chemical binding]; other site 862719002824 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 862719002825 CRISPR-associated protein; Region: DUF3692; pfam12469 862719002826 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 862719002827 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 862719002828 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 862719002829 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 862719002830 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 862719002831 Winged helix-turn helix; Region: HTH_29; pfam13551 862719002832 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719002833 Homeodomain-like domain; Region: HTH_32; pfam13565 862719002834 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719002835 Evidence 7 : Gene remnant; Product type e : enzyme 862719002836 Evidence 7 : Gene remnant; Product type e : enzyme 862719002837 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719002838 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 862719002839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 862719002840 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 862719002841 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 862719002842 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 862719002843 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 862719002844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 862719002845 Transposase; Region: HTH_Tnp_1; pfam01527 862719002846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 862719002847 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002848 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002849 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719002850 Winged helix-turn helix; Region: HTH_29; pfam13551 862719002851 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719002852 Homeodomain-like domain; Region: HTH_32; pfam13565 862719002853 Evidence 7 : Gene remnant; Product type e : enzyme 862719002854 Evidence 7 : Gene remnant; Product type e : enzyme 862719002855 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719002856 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002857 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002858 SIR2-like domain; Region: SIR2_2; pfam13289 862719002859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719002860 binding surface 862719002861 TPR motif; other site 862719002862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719002863 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002864 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002865 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002866 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 862719002867 Winged helix-turn helix; Region: HTH_29; pfam13551 862719002868 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719002869 Homeodomain-like domain; Region: HTH_32; pfam13565 862719002870 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719002871 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 862719002872 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 862719002873 active site 862719002874 homodimer interface [polypeptide binding]; other site 862719002875 SAM binding site [chemical binding]; other site 862719002876 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 862719002877 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719002878 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862719002879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719002880 Walker A/P-loop; other site 862719002881 ATP binding site [chemical binding]; other site 862719002882 Q-loop/lid; other site 862719002883 ABC transporter signature motif; other site 862719002884 Walker B; other site 862719002885 D-loop; other site 862719002886 H-loop/switch region; other site 862719002887 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719002888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719002889 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862719002890 Walker A/P-loop; other site 862719002891 ATP binding site [chemical binding]; other site 862719002892 Q-loop/lid; other site 862719002893 ABC transporter signature motif; other site 862719002894 Walker B; other site 862719002895 D-loop; other site 862719002896 H-loop/switch region; other site 862719002897 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719002898 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719002899 Walker A/P-loop; other site 862719002900 ATP binding site [chemical binding]; other site 862719002901 Q-loop/lid; other site 862719002902 ABC transporter signature motif; other site 862719002903 Walker B; other site 862719002904 D-loop; other site 862719002905 H-loop/switch region; other site 862719002906 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 862719002907 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719002908 dimer interface [polypeptide binding]; other site 862719002909 putative PBP binding regions; other site 862719002910 ABC-ATPase subunit interface; other site 862719002911 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 862719002912 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862719002913 intersubunit interface [polypeptide binding]; other site 862719002914 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 862719002915 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719002916 N-terminal plug; other site 862719002917 ligand-binding site [chemical binding]; other site 862719002918 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 862719002919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002920 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 862719002921 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 862719002922 acyl-activating enzyme (AAE) consensus motif; other site 862719002923 active site 862719002924 AMP binding site [chemical binding]; other site 862719002925 substrate binding site [chemical binding]; other site 862719002926 Phosphopantetheine attachment site; Region: PP-binding; cl09936 862719002927 Condensation domain; Region: Condensation; pfam00668 862719002928 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 862719002929 Nonribosomal peptide synthase; Region: NRPS; pfam08415 862719002930 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 862719002931 acyl-activating enzyme (AAE) consensus motif; other site 862719002932 AMP binding site [chemical binding]; other site 862719002933 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 862719002934 Condensation domain; Region: Condensation; pfam00668 862719002935 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 862719002936 Nonribosomal peptide synthase; Region: NRPS; pfam08415 862719002937 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 862719002938 acyl-activating enzyme (AAE) consensus motif; other site 862719002939 AMP binding site [chemical binding]; other site 862719002940 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719002941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719002942 S-adenosylmethionine binding site [chemical binding]; other site 862719002943 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719002944 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 862719002945 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 862719002946 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 862719002947 Chorismate mutase type II; Region: CM_2; cl00693 862719002948 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 862719002949 chorismate binding enzyme; Region: Chorismate_bind; cl10555 862719002950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719002951 hypothetical protein; Provisional; Region: PRK09262 862719002952 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 862719002953 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 862719002954 NAD binding site [chemical binding]; other site 862719002955 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 862719002956 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719002957 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719002958 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719002959 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 862719002960 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 862719002961 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002962 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 862719002963 DctM-like transporters; Region: DctM; pfam06808 862719002964 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 862719002965 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 862719002966 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 862719002967 inhibitor site; inhibition site 862719002968 active site 862719002969 dimer interface [polypeptide binding]; other site 862719002970 catalytic residue [active] 862719002971 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 862719002972 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 862719002973 substrate binding site [chemical binding]; other site 862719002974 ATP binding site [chemical binding]; other site 862719002975 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719002976 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 862719002977 Transcriptional regulators [Transcription]; Region: PurR; COG1609 862719002978 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719002979 DNA binding site [nucleotide binding] 862719002980 domain linker motif; other site 862719002981 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 862719002982 putative dimerization interface [polypeptide binding]; other site 862719002983 putative ligand binding site [chemical binding]; other site 862719002984 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719002985 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719002986 Cupin domain; Region: Cupin_2; pfam07883 862719002987 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 862719002988 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 862719002989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719002990 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 862719002991 Fusaric acid resistance protein family; Region: FUSC; pfam04632 862719002992 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 862719002993 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719002994 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719002995 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719002996 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862719002997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 862719002998 Walker A motif; other site 862719002999 ATP binding site [chemical binding]; other site 862719003000 Walker B motif; other site 862719003001 arginine finger; other site 862719003002 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862719003003 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 862719003004 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719003005 DNA-binding site [nucleotide binding]; DNA binding site 862719003006 UTRA domain; Region: UTRA; pfam07702 862719003007 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 862719003008 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719003009 active site 862719003010 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 862719003011 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 862719003012 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 862719003013 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 862719003014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719003015 Walker A/P-loop; other site 862719003016 ATP binding site [chemical binding]; other site 862719003017 Q-loop/lid; other site 862719003018 ABC transporter signature motif; other site 862719003019 Walker B; other site 862719003020 D-loop; other site 862719003021 H-loop/switch region; other site 862719003022 TOBE domain; Region: TOBE_2; pfam08402 862719003023 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 862719003024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003025 putative PBP binding loops; other site 862719003026 ABC-ATPase subunit interface; other site 862719003027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003028 dimer interface [polypeptide binding]; other site 862719003029 conserved gate region; other site 862719003030 putative PBP binding loops; other site 862719003031 ABC-ATPase subunit interface; other site 862719003032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719003033 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 862719003034 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719003035 dimerization interface [polypeptide binding]; other site 862719003036 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719003037 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719003038 catalytic residue [active] 862719003039 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 862719003040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719003041 motif II; other site 862719003042 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 862719003043 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719003044 inhibitor-cofactor binding pocket; inhibition site 862719003045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719003046 catalytic residue [active] 862719003047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719003048 dimerization interface [polypeptide binding]; other site 862719003049 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719003050 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719003051 dimer interface [polypeptide binding]; other site 862719003052 putative CheW interface [polypeptide binding]; other site 862719003053 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719003054 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 862719003055 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 862719003056 ligand binding site [chemical binding]; other site 862719003057 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 862719003058 dimerization interface [polypeptide binding]; other site 862719003059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719003060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003061 ATP binding site [chemical binding]; other site 862719003062 Mg2+ binding site [ion binding]; other site 862719003063 G-X-G motif; other site 862719003064 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719003065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 862719003066 active site 862719003067 phosphorylation site [posttranslational modification] 862719003068 intermolecular recognition site; other site 862719003069 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719003070 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719003071 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719003072 metal binding site [ion binding]; metal-binding site 862719003073 active site 862719003074 I-site; other site 862719003075 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719003076 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 862719003077 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 862719003078 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 862719003079 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862719003080 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 862719003081 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 862719003082 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 862719003083 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 862719003084 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 862719003085 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 862719003086 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 862719003087 putative catalytic cysteine [active] 862719003088 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719003089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719003090 Walker A/P-loop; other site 862719003091 ATP binding site [chemical binding]; other site 862719003092 Q-loop/lid; other site 862719003093 ABC transporter signature motif; other site 862719003094 Walker B; other site 862719003095 D-loop; other site 862719003096 H-loop/switch region; other site 862719003097 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719003098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003099 dimer interface [polypeptide binding]; other site 862719003100 conserved gate region; other site 862719003101 putative PBP binding loops; other site 862719003102 ABC-ATPase subunit interface; other site 862719003103 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719003104 NMT1/THI5 like; Region: NMT1; pfam09084 862719003105 substrate binding pocket [chemical binding]; other site 862719003106 membrane-bound complex binding site; other site 862719003107 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 862719003108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719003109 NAD(P) binding site [chemical binding]; other site 862719003110 active site 862719003111 phosphoglycolate phosphatase; Provisional; Region: PRK13222 862719003112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719003113 motif II; other site 862719003114 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 862719003115 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 862719003116 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 862719003117 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 862719003118 serine transporter; Region: stp; TIGR00814 862719003119 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 862719003120 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 862719003121 Histidine kinase; Region: His_kinase; pfam06580 862719003122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003123 ATP binding site [chemical binding]; other site 862719003124 Mg2+ binding site [ion binding]; other site 862719003125 G-X-G motif; other site 862719003126 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 862719003127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003128 active site 862719003129 phosphorylation site [posttranslational modification] 862719003130 intermolecular recognition site; other site 862719003131 dimerization interface [polypeptide binding]; other site 862719003132 LytTr DNA-binding domain; Region: LytTR; pfam04397 862719003133 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 862719003134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719003135 HAMP domain; Region: HAMP; pfam00672 862719003136 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 862719003137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003138 ATP binding site [chemical binding]; other site 862719003139 Mg2+ binding site [ion binding]; other site 862719003140 G-X-G motif; other site 862719003141 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 862719003142 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 862719003143 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719003144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003145 active site 862719003146 phosphorylation site [posttranslational modification] 862719003147 intermolecular recognition site; other site 862719003148 dimerization interface [polypeptide binding]; other site 862719003149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719003150 DNA binding site [nucleotide binding] 862719003151 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719003152 Ligand Binding Site [chemical binding]; other site 862719003153 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719003154 Ligand Binding Site [chemical binding]; other site 862719003155 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 862719003156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 862719003157 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 862719003158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719003159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719003160 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719003161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003162 active site 862719003163 phosphorylation site [posttranslational modification] 862719003164 intermolecular recognition site; other site 862719003165 dimerization interface [polypeptide binding]; other site 862719003166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719003167 DNA binding residues [nucleotide binding] 862719003168 dimerization interface [polypeptide binding]; other site 862719003169 Histidine kinase; Region: HisKA_3; pfam07730 862719003170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003171 ATP binding site [chemical binding]; other site 862719003172 Mg2+ binding site [ion binding]; other site 862719003173 G-X-G motif; other site 862719003174 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 862719003175 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 862719003176 dimer interface [polypeptide binding]; other site 862719003177 Trp docking motif [polypeptide binding]; other site 862719003178 active site 862719003179 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719003180 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719003181 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 862719003182 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719003183 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 862719003184 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 862719003185 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 862719003186 kynureninase; Region: kynureninase; TIGR01814 862719003187 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719003188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719003189 catalytic residue [active] 862719003190 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 862719003191 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 862719003192 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719003193 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 862719003194 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; pfam01184 862719003195 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719003196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719003197 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719003198 dimerization interface [polypeptide binding]; other site 862719003199 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719003200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719003201 NAD(P) binding site [chemical binding]; other site 862719003202 active site 862719003203 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 862719003204 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 862719003205 TPP-binding site [chemical binding]; other site 862719003206 dimer interface [polypeptide binding]; other site 862719003207 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862719003208 PYR/PP interface [polypeptide binding]; other site 862719003209 dimer interface [polypeptide binding]; other site 862719003210 TPP binding site [chemical binding]; other site 862719003211 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719003212 glycerate dehydrogenase; Provisional; Region: PRK06932 862719003213 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 862719003214 putative ligand binding site [chemical binding]; other site 862719003215 putative NAD binding site [chemical binding]; other site 862719003216 catalytic site [active] 862719003217 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 862719003218 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 862719003219 MOFRL family; Region: MOFRL; pfam05161 862719003220 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719003221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719003222 DNA-binding site [nucleotide binding]; DNA binding site 862719003223 FCD domain; Region: FCD; pfam07729 862719003224 NMT1-like family; Region: NMT1_2; pfam13379 862719003225 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 862719003226 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719003227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003228 dimer interface [polypeptide binding]; other site 862719003229 conserved gate region; other site 862719003230 putative PBP binding loops; other site 862719003231 ABC-ATPase subunit interface; other site 862719003232 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719003233 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 862719003234 Walker A/P-loop; other site 862719003235 ATP binding site [chemical binding]; other site 862719003236 Q-loop/lid; other site 862719003237 ABC transporter signature motif; other site 862719003238 Walker B; other site 862719003239 D-loop; other site 862719003240 H-loop/switch region; other site 862719003241 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 862719003242 dihydropyrimidinase; Provisional; Region: PRK13404 862719003243 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 862719003244 tetramer interface [polypeptide binding]; other site 862719003245 active site 862719003246 mannonate dehydratase; Region: uxuA; TIGR00695 862719003247 mannonate dehydratase; Provisional; Region: PRK03906 862719003248 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 862719003249 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 862719003250 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 862719003251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719003252 D-galactonate transporter; Region: 2A0114; TIGR00893 862719003253 putative substrate translocation pore; other site 862719003254 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 862719003255 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719003256 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719003257 metal binding site [ion binding]; metal-binding site 862719003258 active site 862719003259 I-site; other site 862719003260 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719003261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719003262 DNA-binding site [nucleotide binding]; DNA binding site 862719003263 FCD domain; Region: FCD; pfam07729 862719003264 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 862719003265 Amidase; Region: Amidase; cl11426 862719003266 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 862719003267 active site 862719003268 homotetramer interface [polypeptide binding]; other site 862719003269 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719003270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003271 dimer interface [polypeptide binding]; other site 862719003272 conserved gate region; other site 862719003273 putative PBP binding loops; other site 862719003274 ABC-ATPase subunit interface; other site 862719003275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003276 dimer interface [polypeptide binding]; other site 862719003277 conserved gate region; other site 862719003278 putative PBP binding loops; other site 862719003279 ABC-ATPase subunit interface; other site 862719003280 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 862719003281 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 862719003282 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719003283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719003284 Walker A/P-loop; other site 862719003285 ATP binding site [chemical binding]; other site 862719003286 Q-loop/lid; other site 862719003287 ABC transporter signature motif; other site 862719003288 Walker B; other site 862719003289 D-loop; other site 862719003290 H-loop/switch region; other site 862719003291 TOBE domain; Region: TOBE_2; pfam08402 862719003292 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 862719003293 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 862719003294 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 862719003295 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 862719003296 FliG C-terminal domain; Region: FliG_C; pfam01706 862719003297 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 862719003298 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862719003299 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 862719003300 putative active site [active] 862719003301 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 862719003302 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 862719003303 homodimer interface [polypeptide binding]; other site 862719003304 substrate-cofactor binding pocket; other site 862719003305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719003306 catalytic residue [active] 862719003307 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 862719003308 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719003309 Walker A/P-loop; other site 862719003310 ATP binding site [chemical binding]; other site 862719003311 Q-loop/lid; other site 862719003312 ABC transporter signature motif; other site 862719003313 Walker B; other site 862719003314 D-loop; other site 862719003315 H-loop/switch region; other site 862719003316 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 862719003317 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719003318 Walker A/P-loop; other site 862719003319 ATP binding site [chemical binding]; other site 862719003320 Q-loop/lid; other site 862719003321 ABC transporter signature motif; other site 862719003322 Walker B; other site 862719003323 D-loop; other site 862719003324 H-loop/switch region; other site 862719003325 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719003326 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 862719003327 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 862719003328 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 862719003329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003330 dimer interface [polypeptide binding]; other site 862719003331 conserved gate region; other site 862719003332 putative PBP binding loops; other site 862719003333 ABC-ATPase subunit interface; other site 862719003334 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 862719003335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003336 dimer interface [polypeptide binding]; other site 862719003337 conserved gate region; other site 862719003338 putative PBP binding loops; other site 862719003339 ABC-ATPase subunit interface; other site 862719003340 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 862719003341 homodimer interface [polypeptide binding]; other site 862719003342 homotetramer interface [polypeptide binding]; other site 862719003343 active site pocket [active] 862719003344 cleavage site 862719003345 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 862719003346 SxDxEG motif; other site 862719003347 active site 862719003348 metal binding site [ion binding]; metal-binding site 862719003349 homopentamer interface [polypeptide binding]; other site 862719003350 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 862719003351 catalytic nucleophile [active] 862719003352 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 862719003353 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 862719003354 putative NAD(P) binding site [chemical binding]; other site 862719003355 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 862719003356 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 862719003357 dimer interface [polypeptide binding]; other site 862719003358 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 862719003359 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719003360 Walker A/P-loop; other site 862719003361 ATP binding site [chemical binding]; other site 862719003362 Q-loop/lid; other site 862719003363 ABC transporter signature motif; other site 862719003364 Walker B; other site 862719003365 D-loop; other site 862719003366 H-loop/switch region; other site 862719003367 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719003368 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 862719003369 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719003370 Walker A/P-loop; other site 862719003371 ATP binding site [chemical binding]; other site 862719003372 Q-loop/lid; other site 862719003373 ABC transporter signature motif; other site 862719003374 Walker B; other site 862719003375 D-loop; other site 862719003376 H-loop/switch region; other site 862719003377 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719003378 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 862719003379 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 862719003380 dimer interface [polypeptide binding]; other site 862719003381 active site 862719003382 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862719003383 substrate binding site [chemical binding]; other site 862719003384 catalytic residue [active] 862719003385 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 862719003386 homotrimer interaction site [polypeptide binding]; other site 862719003387 putative active site [active] 862719003388 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 862719003389 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719003390 active site 862719003391 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719003392 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 862719003393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003394 dimer interface [polypeptide binding]; other site 862719003395 conserved gate region; other site 862719003396 putative PBP binding loops; other site 862719003397 ABC-ATPase subunit interface; other site 862719003398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719003399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003400 dimer interface [polypeptide binding]; other site 862719003401 conserved gate region; other site 862719003402 putative PBP binding loops; other site 862719003403 ABC-ATPase subunit interface; other site 862719003404 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719003405 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 862719003406 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719003407 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 862719003408 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719003409 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 862719003410 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 862719003411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003412 active site 862719003413 phosphorylation site [posttranslational modification] 862719003414 intermolecular recognition site; other site 862719003415 dimerization interface [polypeptide binding]; other site 862719003416 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719003417 DNA binding residues [nucleotide binding] 862719003418 dimerization interface [polypeptide binding]; other site 862719003419 MASE1; Region: MASE1; cl17823 862719003420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719003421 dimer interface [polypeptide binding]; other site 862719003422 phosphorylation site [posttranslational modification] 862719003423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003424 ATP binding site [chemical binding]; other site 862719003425 Mg2+ binding site [ion binding]; other site 862719003426 G-X-G motif; other site 862719003427 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719003428 Ligand Binding Site [chemical binding]; other site 862719003429 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719003430 Ligand Binding Site [chemical binding]; other site 862719003431 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 862719003432 active site 862719003433 phosphorylation site [posttranslational modification] 862719003434 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 862719003435 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 862719003436 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719003437 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 862719003438 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 862719003439 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 862719003440 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 862719003441 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719003442 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 862719003443 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 862719003444 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671 862719003445 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 862719003446 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 862719003447 P-loop; other site 862719003448 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 862719003449 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 862719003450 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 862719003451 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 862719003452 FHIPEP family; Region: FHIPEP; pfam00771 862719003453 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719003454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719003455 Walker A motif; other site 862719003456 ATP binding site [chemical binding]; other site 862719003457 Walker B motif; other site 862719003458 arginine finger; other site 862719003459 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719003460 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 862719003461 flagellar motor switch protein; Reviewed; Region: PRK08916 862719003462 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 862719003463 flagellar assembly protein H; Validated; Region: fliH; PRK06032 862719003464 Flagellar assembly protein FliH; Region: FliH; pfam02108 862719003465 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 862719003466 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 862719003467 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 862719003468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719003469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719003470 non-specific DNA binding site [nucleotide binding]; other site 862719003471 salt bridge; other site 862719003472 sequence-specific DNA binding site [nucleotide binding]; other site 862719003473 HD domain; Region: HD_3; cl17350 862719003474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719003475 putative active site [active] 862719003476 heme pocket [chemical binding]; other site 862719003477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719003478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719003479 dimer interface [polypeptide binding]; other site 862719003480 phosphorylation site [posttranslational modification] 862719003481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003482 ATP binding site [chemical binding]; other site 862719003483 Mg2+ binding site [ion binding]; other site 862719003484 G-X-G motif; other site 862719003485 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003487 active site 862719003488 phosphorylation site [posttranslational modification] 862719003489 intermolecular recognition site; other site 862719003490 dimerization interface [polypeptide binding]; other site 862719003491 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719003492 putative binding surface; other site 862719003493 active site 862719003494 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003496 active site 862719003497 phosphorylation site [posttranslational modification] 862719003498 intermolecular recognition site; other site 862719003499 dimerization interface [polypeptide binding]; other site 862719003500 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 862719003501 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 862719003502 Domain of unknown function DUF21; Region: DUF21; pfam01595 862719003503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 862719003504 Transporter associated domain; Region: CorC_HlyC; smart01091 862719003505 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 862719003506 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 862719003507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719003508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719003509 dimer interface [polypeptide binding]; other site 862719003510 phosphorylation site [posttranslational modification] 862719003511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003512 ATP binding site [chemical binding]; other site 862719003513 Mg2+ binding site [ion binding]; other site 862719003514 G-X-G motif; other site 862719003515 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719003516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003517 active site 862719003518 phosphorylation site [posttranslational modification] 862719003519 intermolecular recognition site; other site 862719003520 dimerization interface [polypeptide binding]; other site 862719003521 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003523 active site 862719003524 phosphorylation site [posttranslational modification] 862719003525 intermolecular recognition site; other site 862719003526 dimerization interface [polypeptide binding]; other site 862719003527 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719003528 DNA binding residues [nucleotide binding] 862719003529 PIN domain; Region: PIN_3; pfam13470 862719003530 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 862719003531 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 862719003532 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719003533 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 862719003534 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 862719003535 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 862719003536 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 862719003537 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 862719003538 Uncharacterized conserved protein [Function unknown]; Region: COG3791 862719003539 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 862719003540 thiamine pyrophosphate protein; Provisional; Region: PRK08273 862719003541 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 862719003542 PYR/PP interface [polypeptide binding]; other site 862719003543 dimer interface [polypeptide binding]; other site 862719003544 tetramer interface [polypeptide binding]; other site 862719003545 TPP binding site [chemical binding]; other site 862719003546 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 862719003547 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 862719003548 TPP-binding site [chemical binding]; other site 862719003549 Sensors of blue-light using FAD; Region: BLUF; pfam04940 862719003550 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 862719003551 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862719003552 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719003553 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719003554 ligand binding site [chemical binding]; other site 862719003555 flexible hinge region; other site 862719003556 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 862719003557 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 862719003558 active site 862719003559 dimer interface [polypeptide binding]; other site 862719003560 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 862719003561 Ligand Binding Site [chemical binding]; other site 862719003562 Molecular Tunnel; other site 862719003563 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 862719003564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719003565 Coenzyme A binding pocket [chemical binding]; other site 862719003566 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719003567 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719003568 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 862719003569 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 862719003570 putative oligomer interface [polypeptide binding]; other site 862719003571 putative active site [active] 862719003572 metal binding site [ion binding]; metal-binding site 862719003573 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719003574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719003575 dimer interface [polypeptide binding]; other site 862719003576 phosphorylation site [posttranslational modification] 862719003577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003578 ATP binding site [chemical binding]; other site 862719003579 Mg2+ binding site [ion binding]; other site 862719003580 G-X-G motif; other site 862719003581 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719003582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003583 active site 862719003584 phosphorylation site [posttranslational modification] 862719003585 intermolecular recognition site; other site 862719003586 dimerization interface [polypeptide binding]; other site 862719003587 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003589 active site 862719003590 phosphorylation site [posttranslational modification] 862719003591 intermolecular recognition site; other site 862719003592 dimerization interface [polypeptide binding]; other site 862719003593 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 862719003594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003595 active site 862719003596 phosphorylation site [posttranslational modification] 862719003597 intermolecular recognition site; other site 862719003598 dimerization interface [polypeptide binding]; other site 862719003599 CheB methylesterase; Region: CheB_methylest; pfam01339 862719003600 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719003601 putative binding surface; other site 862719003602 active site 862719003603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003604 ATP binding site [chemical binding]; other site 862719003605 Mg2+ binding site [ion binding]; other site 862719003606 G-X-G motif; other site 862719003607 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003609 active site 862719003610 phosphorylation site [posttranslational modification] 862719003611 intermolecular recognition site; other site 862719003612 dimerization interface [polypeptide binding]; other site 862719003613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719003614 dimerization interface [polypeptide binding]; other site 862719003615 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719003616 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719003617 dimer interface [polypeptide binding]; other site 862719003618 putative CheW interface [polypeptide binding]; other site 862719003619 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 862719003620 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 862719003621 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 862719003622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719003623 TPR motif; other site 862719003624 binding surface 862719003625 CheW-like domain; Region: CheW; pfam01584 862719003626 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 862719003627 putative active site [active] 862719003628 putative catalytic site [active] 862719003629 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862719003630 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 862719003631 active site 862719003632 metal binding site [ion binding]; metal-binding site 862719003633 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 862719003634 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 862719003635 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 862719003636 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 862719003637 phosphate binding site [ion binding]; other site 862719003638 Nitrate and nitrite sensing; Region: NIT; pfam08376 862719003639 ANTAR domain; Region: ANTAR; pfam03861 862719003640 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 862719003641 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719003642 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 862719003643 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 862719003644 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 862719003645 NAD binding site [chemical binding]; other site 862719003646 homodimer interface [polypeptide binding]; other site 862719003647 active site 862719003648 substrate binding site [chemical binding]; other site 862719003649 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 862719003650 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 862719003651 Walker A/P-loop; other site 862719003652 ATP binding site [chemical binding]; other site 862719003653 Q-loop/lid; other site 862719003654 ABC transporter signature motif; other site 862719003655 Walker B; other site 862719003656 D-loop; other site 862719003657 H-loop/switch region; other site 862719003658 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719003659 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719003660 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719003661 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 862719003662 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719003663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719003664 S-adenosylmethionine binding site [chemical binding]; other site 862719003665 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 862719003666 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719003667 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 862719003668 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719003669 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 862719003670 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 862719003671 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 862719003672 DEAD-like helicases superfamily; Region: DEXDc; smart00487 862719003673 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719003674 ATP binding site [chemical binding]; other site 862719003675 putative Mg++ binding site [ion binding]; other site 862719003676 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719003677 nucleotide binding region [chemical binding]; other site 862719003678 ATP-binding site [chemical binding]; other site 862719003679 TRCF domain; Region: TRCF; pfam03461 862719003680 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 862719003681 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 862719003682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719003683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719003684 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 862719003685 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 862719003686 DNA binding site [nucleotide binding] 862719003687 active site 862719003688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 862719003689 ABC-2 type transporter; Region: ABC2_membrane; cl17235 862719003690 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 862719003691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719003692 Walker A/P-loop; other site 862719003693 ATP binding site [chemical binding]; other site 862719003694 Q-loop/lid; other site 862719003695 ABC transporter signature motif; other site 862719003696 Walker B; other site 862719003697 D-loop; other site 862719003698 H-loop/switch region; other site 862719003699 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 862719003700 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719003701 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719003702 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719003703 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719003704 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 862719003705 ligand binding site [chemical binding]; other site 862719003706 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719003707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719003708 substrate binding pocket [chemical binding]; other site 862719003709 membrane-bound complex binding site; other site 862719003710 hinge residues; other site 862719003711 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 862719003712 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 862719003713 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 862719003714 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 862719003715 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 862719003716 dimer interface [polypeptide binding]; other site 862719003717 Trp docking motif [polypeptide binding]; other site 862719003718 active site 862719003719 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 862719003720 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719003721 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719003722 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 862719003723 substrate binding pocket [chemical binding]; other site 862719003724 membrane-bound complex binding site; other site 862719003725 hinge residues; other site 862719003726 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719003727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719003728 dimer interface [polypeptide binding]; other site 862719003729 conserved gate region; other site 862719003730 putative PBP binding loops; other site 862719003731 ABC-ATPase subunit interface; other site 862719003732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719003733 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 862719003734 Walker A/P-loop; other site 862719003735 ATP binding site [chemical binding]; other site 862719003736 Q-loop/lid; other site 862719003737 ABC transporter signature motif; other site 862719003738 Walker B; other site 862719003739 D-loop; other site 862719003740 H-loop/switch region; other site 862719003741 Protein of unknown function (DUF461); Region: DUF461; pfam04314 862719003742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719003743 putative active site [active] 862719003744 heme pocket [chemical binding]; other site 862719003745 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719003746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003747 active site 862719003748 phosphorylation site [posttranslational modification] 862719003749 intermolecular recognition site; other site 862719003750 dimerization interface [polypeptide binding]; other site 862719003751 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719003752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003753 active site 862719003754 phosphorylation site [posttranslational modification] 862719003755 intermolecular recognition site; other site 862719003756 dimerization interface [polypeptide binding]; other site 862719003757 PAS domain S-box; Region: sensory_box; TIGR00229 862719003758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719003759 putative active site [active] 862719003760 heme pocket [chemical binding]; other site 862719003761 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719003762 HWE histidine kinase; Region: HWE_HK; pfam07536 862719003763 Response regulator receiver domain; Region: Response_reg; pfam00072 862719003764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719003765 active site 862719003766 phosphorylation site [posttranslational modification] 862719003767 intermolecular recognition site; other site 862719003768 dimerization interface [polypeptide binding]; other site 862719003769 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 862719003770 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 862719003771 Phytochrome region; Region: PHY; pfam00360 862719003772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719003773 dimer interface [polypeptide binding]; other site 862719003774 phosphorylation site [posttranslational modification] 862719003775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719003776 ATP binding site [chemical binding]; other site 862719003777 Mg2+ binding site [ion binding]; other site 862719003778 G-X-G motif; other site 862719003779 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 862719003780 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 862719003781 FMN binding site [chemical binding]; other site 862719003782 substrate binding site [chemical binding]; other site 862719003783 putative catalytic residue [active] 862719003784 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 862719003785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719003786 DNA-binding site [nucleotide binding]; DNA binding site 862719003787 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719003788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719003789 homodimer interface [polypeptide binding]; other site 862719003790 catalytic residue [active] 862719003791 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719003792 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 862719003793 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 862719003794 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719003795 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719003796 Cytochrome c; Region: Cytochrom_C; pfam00034 862719003797 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 862719003798 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 862719003799 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 862719003800 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 862719003801 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719003802 catalytic loop [active] 862719003803 iron binding site [ion binding]; other site 862719003804 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 862719003805 Transcriptional regulators [Transcription]; Region: MarR; COG1846 862719003806 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 862719003807 hypothetical protein; Provisional; Region: PRK06847 862719003808 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 862719003809 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862719003810 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719003811 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 862719003812 Isochorismatase family; Region: Isochorismatase; pfam00857 862719003813 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 862719003814 catalytic triad [active] 862719003815 substrate binding site [chemical binding]; other site 862719003816 domain interfaces; other site 862719003817 conserved cis-peptide bond; other site 862719003818 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 862719003819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719003820 putative substrate translocation pore; other site 862719003821 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719003822 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719003823 dimerization interface [polypeptide binding]; other site 862719003824 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719003825 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719003826 dimer interface [polypeptide binding]; other site 862719003827 putative CheW interface [polypeptide binding]; other site 862719003828 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719003829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719003830 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719003831 putative effector binding pocket; other site 862719003832 dimerization interface [polypeptide binding]; other site 862719003833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719003834 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 862719003835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719003836 active site 862719003837 AMP binding site [chemical binding]; other site 862719003838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719003839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719003840 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 862719003841 putative dimerization interface [polypeptide binding]; other site 862719003842 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719003843 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 862719003844 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 862719003845 DctM-like transporters; Region: DctM; pfam06808 862719003846 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 862719003847 active site 862719003848 catalytic residues [active] 862719003849 metal binding site [ion binding]; metal-binding site 862719003850 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 862719003851 CoA-transferase family III; Region: CoA_transf_3; pfam02515 862719003852 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 862719003853 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 862719003854 trimer interface [polypeptide binding]; other site 862719003855 putative metal binding site [ion binding]; other site 862719003856 ABC-2 type transporter; Region: ABC2_membrane; cl17235 862719003857 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 862719003858 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862719003859 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 862719003860 Walker A/P-loop; other site 862719003861 ATP binding site [chemical binding]; other site 862719003862 Q-loop/lid; other site 862719003863 ABC transporter signature motif; other site 862719003864 Walker B; other site 862719003865 D-loop; other site 862719003866 H-loop/switch region; other site 862719003867 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 862719003868 enolase; Provisional; Region: eno; PRK00077 862719003869 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 862719003870 dimer interface [polypeptide binding]; other site 862719003871 metal binding site [ion binding]; metal-binding site 862719003872 substrate binding pocket [chemical binding]; other site 862719003873 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 862719003874 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 862719003875 dimer interaction site [polypeptide binding]; other site 862719003876 substrate-binding tunnel; other site 862719003877 active site 862719003878 catalytic site [active] 862719003879 substrate binding site [chemical binding]; other site 862719003880 phosphate acetyltransferase; Provisional; Region: PRK11890 862719003881 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 862719003882 propionate/acetate kinase; Provisional; Region: PRK12379 862719003883 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 862719003884 EamA-like transporter family; Region: EamA; pfam00892 862719003885 EamA-like transporter family; Region: EamA; pfam00892 862719003886 Evidence 2b : Function of strongly homologous gene; PubMedId : 7928974; Product type e : enzyme 862719003887 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 862719003888 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 862719003889 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 862719003890 Cytochrome c; Region: Cytochrom_C; pfam00034 862719003891 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 862719003892 Cytochrome c; Region: Cytochrom_C; pfam00034 862719003893 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 862719003894 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 862719003895 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 862719003896 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 862719003897 Caspase domain; Region: Peptidase_C14; pfam00656 862719003898 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 862719003899 active site 862719003900 homodimer interface [polypeptide binding]; other site 862719003901 homotetramer interface [polypeptide binding]; other site 862719003902 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 862719003903 catalytic core [active] 862719003904 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 862719003905 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 862719003906 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719003907 Walker A/P-loop; other site 862719003908 ATP binding site [chemical binding]; other site 862719003909 Q-loop/lid; other site 862719003910 ABC transporter signature motif; other site 862719003911 Walker B; other site 862719003912 D-loop; other site 862719003913 H-loop/switch region; other site 862719003914 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 862719003915 ABC-ATPase subunit interface; other site 862719003916 dimer interface [polypeptide binding]; other site 862719003917 putative PBP binding regions; other site 862719003918 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 862719003919 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719003920 ABC-ATPase subunit interface; other site 862719003921 dimer interface [polypeptide binding]; other site 862719003922 putative PBP binding regions; other site 862719003923 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 862719003924 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 862719003925 putative ligand binding residues [chemical binding]; other site 862719003926 Predicted membrane protein [Function unknown]; Region: COG2510 862719003927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719003928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719003929 hypothetical protein; Validated; Region: PRK09071 862719003930 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 862719003931 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 862719003932 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 862719003933 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719003934 N-terminal plug; other site 862719003935 ligand-binding site [chemical binding]; other site 862719003936 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 862719003937 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 862719003938 Sel1-like repeats; Region: SEL1; smart00671 862719003939 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 862719003940 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 862719003941 active site 862719003942 substrate binding site [chemical binding]; other site 862719003943 FMN binding site [chemical binding]; other site 862719003944 putative catalytic residues [active] 862719003945 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 862719003946 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719003947 acyl-activating enzyme (AAE) consensus motif; other site 862719003948 AMP binding site [chemical binding]; other site 862719003949 active site 862719003950 CoA binding site [chemical binding]; other site 862719003951 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 862719003952 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 862719003953 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719003954 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719003955 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 862719003956 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 862719003957 FAD binding domain; Region: FAD_binding_4; pfam01565 862719003958 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 862719003959 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 862719003960 substrate binding site [chemical binding]; other site 862719003961 ligand binding site [chemical binding]; other site 862719003962 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 862719003963 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 862719003964 substrate binding site [chemical binding]; other site 862719003965 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 862719003966 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 862719003967 tetramer interface [polypeptide binding]; other site 862719003968 active site 862719003969 Mg2+/Mn2+ binding site [ion binding]; other site 862719003970 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719003971 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 862719003972 ligand binding site [chemical binding]; other site 862719003973 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719003974 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719003975 TM-ABC transporter signature motif; other site 862719003976 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719003977 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719003978 TM-ABC transporter signature motif; other site 862719003979 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719003980 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719003981 Walker A/P-loop; other site 862719003982 ATP binding site [chemical binding]; other site 862719003983 Q-loop/lid; other site 862719003984 ABC transporter signature motif; other site 862719003985 Walker B; other site 862719003986 D-loop; other site 862719003987 H-loop/switch region; other site 862719003988 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719003989 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719003990 Walker A/P-loop; other site 862719003991 ATP binding site [chemical binding]; other site 862719003992 Q-loop/lid; other site 862719003993 ABC transporter signature motif; other site 862719003994 Walker B; other site 862719003995 D-loop; other site 862719003996 H-loop/switch region; other site 862719003997 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 862719003998 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 862719003999 FAD binding pocket [chemical binding]; other site 862719004000 FAD binding motif [chemical binding]; other site 862719004001 phosphate binding motif [ion binding]; other site 862719004002 NAD binding pocket [chemical binding]; other site 862719004003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719004004 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 862719004005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719004006 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 862719004007 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719004008 N-terminal plug; other site 862719004009 ligand-binding site [chemical binding]; other site 862719004010 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 862719004011 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719004012 Walker A/P-loop; other site 862719004013 ATP binding site [chemical binding]; other site 862719004014 Q-loop/lid; other site 862719004015 ABC transporter signature motif; other site 862719004016 Walker B; other site 862719004017 D-loop; other site 862719004018 H-loop/switch region; other site 862719004019 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 862719004020 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 862719004021 siderophore binding site; other site 862719004022 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 862719004023 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719004024 ABC-ATPase subunit interface; other site 862719004025 dimer interface [polypeptide binding]; other site 862719004026 putative PBP binding regions; other site 862719004027 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 862719004028 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719004029 dimer interface [polypeptide binding]; other site 862719004030 putative PBP binding regions; other site 862719004031 ABC-ATPase subunit interface; other site 862719004032 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862719004033 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719004034 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 862719004035 Walker A/P-loop; other site 862719004036 ATP binding site [chemical binding]; other site 862719004037 Q-loop/lid; other site 862719004038 ABC transporter signature motif; other site 862719004039 Walker B; other site 862719004040 D-loop; other site 862719004041 H-loop/switch region; other site 862719004042 BCCT family transporter; Region: BCCT; pfam02028 862719004043 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719004044 dimerization interface [polypeptide binding]; other site 862719004045 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719004046 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719004047 dimer interface [polypeptide binding]; other site 862719004048 putative CheW interface [polypeptide binding]; other site 862719004049 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 862719004050 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 862719004051 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862719004052 Soluble P-type ATPase [General function prediction only]; Region: COG4087 862719004053 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 862719004054 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 862719004055 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 862719004056 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 862719004057 Ligand Binding Site [chemical binding]; other site 862719004058 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 862719004059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719004060 dimer interface [polypeptide binding]; other site 862719004061 phosphorylation site [posttranslational modification] 862719004062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004063 ATP binding site [chemical binding]; other site 862719004064 Mg2+ binding site [ion binding]; other site 862719004065 G-X-G motif; other site 862719004066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719004067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004068 active site 862719004069 phosphorylation site [posttranslational modification] 862719004070 intermolecular recognition site; other site 862719004071 dimerization interface [polypeptide binding]; other site 862719004072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719004073 DNA binding site [nucleotide binding] 862719004074 ornithine cyclodeaminase; Validated; Region: PRK07589 862719004075 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 862719004076 Arginase family; Region: Arginase; cd09989 862719004077 agmatinase; Region: agmatinase; TIGR01230 862719004078 active site 862719004079 Mn binding site [ion binding]; other site 862719004080 oligomer interface [polypeptide binding]; other site 862719004081 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719004082 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 862719004083 AsnC family; Region: AsnC_trans_reg; pfam01037 862719004084 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 862719004085 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719004086 substrate binding pocket [chemical binding]; other site 862719004087 membrane-bound complex binding site; other site 862719004088 hinge residues; other site 862719004089 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 862719004090 4Fe-4S binding domain; Region: Fer4_5; pfam12801 862719004091 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862719004092 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 862719004093 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 862719004094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719004095 DNA-binding site [nucleotide binding]; DNA binding site 862719004096 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719004097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719004098 homodimer interface [polypeptide binding]; other site 862719004099 catalytic residue [active] 862719004100 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 862719004101 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 862719004102 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 862719004103 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 862719004104 NADH dehydrogenase; Region: NADHdh; cl00469 862719004105 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 862719004106 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719004107 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 862719004108 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719004109 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 862719004110 MoaE interaction surface [polypeptide binding]; other site 862719004111 MoeB interaction surface [polypeptide binding]; other site 862719004112 thiocarboxylated glycine; other site 862719004113 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 862719004114 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 862719004115 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 862719004116 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719004117 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 862719004118 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 862719004119 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 862719004120 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719004121 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719004122 DNA binding residues [nucleotide binding] 862719004123 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 862719004124 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 862719004125 NADP binding site [chemical binding]; other site 862719004126 homodimer interface [polypeptide binding]; other site 862719004127 active site 862719004128 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 862719004129 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 862719004130 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 862719004131 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719004132 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719004133 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719004134 dimerization interface [polypeptide binding]; other site 862719004135 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719004136 dimer interface [polypeptide binding]; other site 862719004137 putative CheW interface [polypeptide binding]; other site 862719004138 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719004139 catalytic core [active] 862719004140 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862719004141 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719004142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719004143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719004144 putative substrate translocation pore; other site 862719004145 FeoA domain; Region: FeoA; pfam04023 862719004146 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 862719004147 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 862719004148 G1 box; other site 862719004149 GTP/Mg2+ binding site [chemical binding]; other site 862719004150 Switch I region; other site 862719004151 G2 box; other site 862719004152 G3 box; other site 862719004153 Switch II region; other site 862719004154 G4 box; other site 862719004155 G5 box; other site 862719004156 Nucleoside recognition; Region: Gate; pfam07670 862719004157 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 862719004158 Nucleoside recognition; Region: Gate; pfam07670 862719004159 manganese transport regulator MntR; Provisional; Region: PRK11050 862719004160 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 862719004161 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 862719004162 manganese transport protein MntH; Reviewed; Region: PRK00701 862719004163 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 862719004164 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 862719004165 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 862719004166 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 862719004167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719004168 catalytic residue [active] 862719004169 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719004170 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719004171 putative DNA binding site [nucleotide binding]; other site 862719004172 putative Zn2+ binding site [ion binding]; other site 862719004173 AsnC family; Region: AsnC_trans_reg; pfam01037 862719004174 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 862719004175 amidase; Provisional; Region: PRK07056 862719004176 Amidase; Region: Amidase; cl11426 862719004177 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 862719004178 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719004179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004180 dimer interface [polypeptide binding]; other site 862719004181 ABC-ATPase subunit interface; other site 862719004182 putative PBP binding loops; other site 862719004183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004184 dimer interface [polypeptide binding]; other site 862719004185 conserved gate region; other site 862719004186 putative PBP binding loops; other site 862719004187 ABC-ATPase subunit interface; other site 862719004188 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 862719004189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 862719004190 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719004191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719004192 Walker A/P-loop; other site 862719004193 ATP binding site [chemical binding]; other site 862719004194 Q-loop/lid; other site 862719004195 ABC transporter signature motif; other site 862719004196 Walker B; other site 862719004197 D-loop; other site 862719004198 H-loop/switch region; other site 862719004199 TOBE domain; Region: TOBE_2; pfam08402 862719004200 Transcriptional regulators [Transcription]; Region: FadR; COG2186 862719004201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719004202 DNA-binding site [nucleotide binding]; DNA binding site 862719004203 FCD domain; Region: FCD; pfam07729 862719004204 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 862719004205 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 862719004206 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 862719004207 active site turn [active] 862719004208 phosphorylation site [posttranslational modification] 862719004209 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 862719004210 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 862719004211 putative active site [active] 862719004212 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 862719004213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719004214 DNA-binding site [nucleotide binding]; DNA binding site 862719004215 UTRA domain; Region: UTRA; pfam07702 862719004216 putative phosphatase; Provisional; Region: PRK11587 862719004217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719004218 active site 862719004219 motif I; other site 862719004220 motif II; other site 862719004221 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 862719004222 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 862719004223 active site 862719004224 dimer interface [polypeptide binding]; other site 862719004225 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 862719004226 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 862719004227 dimer interface [polypeptide binding]; other site 862719004228 active site 862719004229 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 862719004230 dimer interface [polypeptide binding]; other site 862719004231 active site 862719004232 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 862719004233 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 862719004234 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 862719004235 active site turn [active] 862719004236 phosphorylation site [posttranslational modification] 862719004237 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 862719004238 active site turn [active] 862719004239 phosphorylation site [posttranslational modification] 862719004240 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 862719004241 HPr interaction site; other site 862719004242 glycerol kinase (GK) interaction site [polypeptide binding]; other site 862719004243 active site 862719004244 phosphorylation site [posttranslational modification] 862719004245 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 862719004246 dimerization domain swap beta strand [polypeptide binding]; other site 862719004247 regulatory protein interface [polypeptide binding]; other site 862719004248 active site 862719004249 regulatory phosphorylation site [posttranslational modification]; other site 862719004250 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 862719004251 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 862719004252 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 862719004253 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 862719004254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719004255 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719004256 dimer interface [polypeptide binding]; other site 862719004257 putative CheW interface [polypeptide binding]; other site 862719004258 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 862719004259 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 862719004260 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 862719004261 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 862719004262 Walker A/P-loop; other site 862719004263 ATP binding site [chemical binding]; other site 862719004264 Q-loop/lid; other site 862719004265 ABC transporter signature motif; other site 862719004266 Walker B; other site 862719004267 D-loop; other site 862719004268 H-loop/switch region; other site 862719004269 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 862719004270 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719004271 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004272 TM-ABC transporter signature motif; other site 862719004273 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 862719004274 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 862719004275 putative ligand binding site [chemical binding]; other site 862719004276 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 862719004277 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 862719004278 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719004279 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 862719004280 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 862719004281 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 862719004282 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862719004283 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 862719004284 Isochorismatase family; Region: Isochorismatase; pfam00857 862719004285 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 862719004286 catalytic triad [active] 862719004287 dimer interface [polypeptide binding]; other site 862719004288 conserved cis-peptide bond; other site 862719004289 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 862719004290 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 862719004291 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 862719004292 active site 862719004293 Predicted membrane protein [Function unknown]; Region: COG2259 862719004294 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 862719004295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004296 active site 862719004297 phosphorylation site [posttranslational modification] 862719004298 intermolecular recognition site; other site 862719004299 dimerization interface [polypeptide binding]; other site 862719004300 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719004301 DNA binding residues [nucleotide binding] 862719004302 dimerization interface [polypeptide binding]; other site 862719004303 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719004304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004305 active site 862719004306 phosphorylation site [posttranslational modification] 862719004307 intermolecular recognition site; other site 862719004308 dimerization interface [polypeptide binding]; other site 862719004309 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719004310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719004311 putative active site [active] 862719004312 heme pocket [chemical binding]; other site 862719004313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719004314 dimer interface [polypeptide binding]; other site 862719004315 phosphorylation site [posttranslational modification] 862719004316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004317 ATP binding site [chemical binding]; other site 862719004318 Mg2+ binding site [ion binding]; other site 862719004319 G-X-G motif; other site 862719004320 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719004321 substrate binding site [chemical binding]; other site 862719004322 activation loop (A-loop); other site 862719004323 Predicted ATPase [General function prediction only]; Region: COG3899 862719004324 AAA ATPase domain; Region: AAA_16; pfam13191 862719004325 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862719004326 GAF domain; Region: GAF; pfam01590 862719004327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719004328 Histidine kinase; Region: HisKA_2; pfam07568 862719004329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004330 ATP binding site [chemical binding]; other site 862719004331 Mg2+ binding site [ion binding]; other site 862719004332 G-X-G motif; other site 862719004333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004334 Response regulator receiver domain; Region: Response_reg; pfam00072 862719004335 active site 862719004336 phosphorylation site [posttranslational modification] 862719004337 intermolecular recognition site; other site 862719004338 dimerization interface [polypeptide binding]; other site 862719004339 RNA polymerase sigma factor; Provisional; Region: PRK11924 862719004340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719004341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719004342 DNA binding residues [nucleotide binding] 862719004343 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 862719004344 FecR protein; Region: FecR; pfam04773 862719004345 Secretin and TonB N terminus short domain; Region: STN; smart00965 862719004346 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 862719004347 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 862719004348 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 862719004349 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 862719004350 IucA / IucC family; Region: IucA_IucC; pfam04183 862719004351 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 862719004352 IucA / IucC family; Region: IucA_IucC; pfam04183 862719004353 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 862719004354 acyl-CoA synthetase; Validated; Region: PRK08308 862719004355 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719004356 acyl-activating enzyme (AAE) consensus motif; other site 862719004357 AMP binding site [chemical binding]; other site 862719004358 active site 862719004359 CoA binding site [chemical binding]; other site 862719004360 acyl carrier protein; Provisional; Region: PRK07639 862719004361 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 862719004362 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 862719004363 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862719004364 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 862719004365 Transposase [DNA replication, recombination, and repair]; Region: COG5433 862719004366 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 862719004367 RNA polymerase sigma factor; Provisional; Region: PRK12547 862719004368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719004369 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719004370 DNA binding residues [nucleotide binding] 862719004371 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 862719004372 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719004373 Walker A/P-loop; other site 862719004374 ATP binding site [chemical binding]; other site 862719004375 Q-loop/lid; other site 862719004376 ABC transporter signature motif; other site 862719004377 Walker B; other site 862719004378 D-loop; other site 862719004379 H-loop/switch region; other site 862719004380 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 862719004381 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 862719004382 putative ligand binding residues [chemical binding]; other site 862719004383 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 862719004384 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719004385 ABC-ATPase subunit interface; other site 862719004386 dimer interface [polypeptide binding]; other site 862719004387 putative PBP binding regions; other site 862719004388 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 862719004389 dimer interface [polypeptide binding]; other site 862719004390 [2Fe-2S] cluster binding site [ion binding]; other site 862719004391 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 862719004392 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719004393 N-terminal plug; other site 862719004394 ligand-binding site [chemical binding]; other site 862719004395 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 862719004396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004397 active site 862719004398 phosphorylation site [posttranslational modification] 862719004399 intermolecular recognition site; other site 862719004400 dimerization interface [polypeptide binding]; other site 862719004401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719004402 DNA binding residues [nucleotide binding] 862719004403 dimerization interface [polypeptide binding]; other site 862719004404 PAS domain; Region: PAS_9; pfam13426 862719004405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719004406 dimer interface [polypeptide binding]; other site 862719004407 phosphorylation site [posttranslational modification] 862719004408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004409 ATP binding site [chemical binding]; other site 862719004410 Mg2+ binding site [ion binding]; other site 862719004411 G-X-G motif; other site 862719004412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719004413 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 862719004414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719004415 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719004416 Predicted membrane protein [Function unknown]; Region: COG2855 862719004417 AAA domain; Region: AAA_30; pfam13604 862719004418 Family description; Region: UvrD_C_2; pfam13538 862719004419 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 862719004420 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 862719004421 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862719004422 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719004423 active site 862719004424 catalytic tetrad [active] 862719004425 Cache domain; Region: Cache_1; pfam02743 862719004426 PAS domain S-box; Region: sensory_box; TIGR00229 862719004427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719004428 putative active site [active] 862719004429 heme pocket [chemical binding]; other site 862719004430 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719004431 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719004432 metal binding site [ion binding]; metal-binding site 862719004433 active site 862719004434 I-site; other site 862719004435 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719004436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719004437 putative DNA binding site [nucleotide binding]; other site 862719004438 putative Zn2+ binding site [ion binding]; other site 862719004439 AsnC family; Region: AsnC_trans_reg; pfam01037 862719004440 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719004441 EamA-like transporter family; Region: EamA; pfam00892 862719004442 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 862719004443 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 862719004444 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 862719004445 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 862719004446 intersubunit interface [polypeptide binding]; other site 862719004447 active site 862719004448 catalytic residue [active] 862719004449 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 862719004450 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 862719004451 ligand binding site [chemical binding]; other site 862719004452 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 862719004453 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 862719004454 Walker A/P-loop; other site 862719004455 ATP binding site [chemical binding]; other site 862719004456 Q-loop/lid; other site 862719004457 ABC transporter signature motif; other site 862719004458 Walker B; other site 862719004459 D-loop; other site 862719004460 H-loop/switch region; other site 862719004461 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 862719004462 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719004463 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004464 TM-ABC transporter signature motif; other site 862719004465 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719004466 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004467 TM-ABC transporter signature motif; other site 862719004468 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 862719004469 active site 862719004470 catalytic residues [active] 862719004471 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 862719004472 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 862719004473 substrate binding site [chemical binding]; other site 862719004474 dimer interface [polypeptide binding]; other site 862719004475 ATP binding site [chemical binding]; other site 862719004476 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 862719004477 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 862719004478 N- and C-terminal domain interface [polypeptide binding]; other site 862719004479 active site 862719004480 MgATP binding site [chemical binding]; other site 862719004481 catalytic site [active] 862719004482 metal binding site [ion binding]; metal-binding site 862719004483 carbohydrate binding site [chemical binding]; other site 862719004484 putative homodimer interface [polypeptide binding]; other site 862719004485 benzoate transport; Region: 2A0115; TIGR00895 862719004486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719004487 putative substrate translocation pore; other site 862719004488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719004489 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 862719004490 Cupin domain; Region: Cupin_2; pfam07883 862719004491 Cupin domain; Region: Cupin_2; cl17218 862719004492 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 862719004493 [2Fe-2S] cluster binding site [ion binding]; other site 862719004494 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 862719004495 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 862719004496 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 862719004497 iron-sulfur cluster [ion binding]; other site 862719004498 [2Fe-2S] cluster binding site [ion binding]; other site 862719004499 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 862719004500 putative alpha subunit interface [polypeptide binding]; other site 862719004501 putative active site [active] 862719004502 putative substrate binding site [chemical binding]; other site 862719004503 Fe binding site [ion binding]; other site 862719004504 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 862719004505 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 862719004506 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719004507 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719004508 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 862719004509 maleylacetoacetate isomerase; Region: maiA; TIGR01262 862719004510 C-terminal domain interface [polypeptide binding]; other site 862719004511 GSH binding site (G-site) [chemical binding]; other site 862719004512 putative dimer interface [polypeptide binding]; other site 862719004513 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 862719004514 dimer interface [polypeptide binding]; other site 862719004515 N-terminal domain interface [polypeptide binding]; other site 862719004516 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 862719004517 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 862719004518 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 862719004519 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 862719004520 Predicted transcriptional regulator [Transcription]; Region: COG2345 862719004521 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 862719004522 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 862719004523 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 862719004524 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 862719004525 malonic semialdehyde reductase; Provisional; Region: PRK10538 862719004526 putative NAD(P) binding site [chemical binding]; other site 862719004527 homodimer interface [polypeptide binding]; other site 862719004528 homotetramer interface [polypeptide binding]; other site 862719004529 active site 862719004530 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719004531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004532 dimer interface [polypeptide binding]; other site 862719004533 conserved gate region; other site 862719004534 putative PBP binding loops; other site 862719004535 ABC-ATPase subunit interface; other site 862719004536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004537 dimer interface [polypeptide binding]; other site 862719004538 conserved gate region; other site 862719004539 ABC-ATPase subunit interface; other site 862719004540 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719004541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719004542 Walker A/P-loop; other site 862719004543 ATP binding site [chemical binding]; other site 862719004544 Q-loop/lid; other site 862719004545 ABC transporter signature motif; other site 862719004546 Walker B; other site 862719004547 D-loop; other site 862719004548 H-loop/switch region; other site 862719004549 TOBE domain; Region: TOBE_2; pfam08402 862719004550 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 862719004551 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 862719004552 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 862719004553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719004554 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 862719004555 putative dimerization interface [polypeptide binding]; other site 862719004556 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719004557 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 862719004558 hydroxyglutarate oxidase; Provisional; Region: PRK11728 862719004559 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 862719004560 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 862719004561 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719004562 hydroxyglutarate oxidase; Provisional; Region: PRK11728 862719004563 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 862719004564 homotrimer interaction site [polypeptide binding]; other site 862719004565 putative active site [active] 862719004566 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719004567 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719004568 substrate binding pocket [chemical binding]; other site 862719004569 membrane-bound complex binding site; other site 862719004570 hinge residues; other site 862719004571 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 862719004572 homotrimer interaction site [polypeptide binding]; other site 862719004573 putative active site [active] 862719004574 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 862719004575 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719004576 N-terminal plug; other site 862719004577 ligand-binding site [chemical binding]; other site 862719004578 putative heme utilization carrier protein HutX; Region: HutX; TIGR04108 862719004579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719004580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719004581 dimer interface [polypeptide binding]; other site 862719004582 phosphorylation site [posttranslational modification] 862719004583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004584 ATP binding site [chemical binding]; other site 862719004585 Mg2+ binding site [ion binding]; other site 862719004586 G-X-G motif; other site 862719004587 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719004588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004589 active site 862719004590 phosphorylation site [posttranslational modification] 862719004591 intermolecular recognition site; other site 862719004592 dimerization interface [polypeptide binding]; other site 862719004593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719004594 DNA binding site [nucleotide binding] 862719004595 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 862719004596 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719004597 Walker A/P-loop; other site 862719004598 ATP binding site [chemical binding]; other site 862719004599 ABC transporter signature motif; other site 862719004600 Walker B; other site 862719004601 D-loop; other site 862719004602 H-loop/switch region; other site 862719004603 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 862719004604 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719004605 ABC-ATPase subunit interface; other site 862719004606 dimer interface [polypeptide binding]; other site 862719004607 putative PBP binding regions; other site 862719004608 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862719004609 intersubunit interface [polypeptide binding]; other site 862719004610 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 862719004611 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 862719004612 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719004613 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 862719004614 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719004615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004616 putative PBP binding loops; other site 862719004617 dimer interface [polypeptide binding]; other site 862719004618 ABC-ATPase subunit interface; other site 862719004619 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 862719004620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719004621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719004622 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 862719004623 Walker A/P-loop; other site 862719004624 ATP binding site [chemical binding]; other site 862719004625 Q-loop/lid; other site 862719004626 ABC transporter signature motif; other site 862719004627 Walker B; other site 862719004628 D-loop; other site 862719004629 H-loop/switch region; other site 862719004630 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719004631 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862719004632 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719004633 Walker A/P-loop; other site 862719004634 ATP binding site [chemical binding]; other site 862719004635 Q-loop/lid; other site 862719004636 ABC transporter signature motif; other site 862719004637 Walker B; other site 862719004638 D-loop; other site 862719004639 H-loop/switch region; other site 862719004640 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719004641 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719004642 substrate binding pocket [chemical binding]; other site 862719004643 membrane-bound complex binding site; other site 862719004644 hinge residues; other site 862719004645 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719004646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004647 dimer interface [polypeptide binding]; other site 862719004648 conserved gate region; other site 862719004649 putative PBP binding loops; other site 862719004650 ABC-ATPase subunit interface; other site 862719004651 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719004652 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 862719004653 Walker A/P-loop; other site 862719004654 ATP binding site [chemical binding]; other site 862719004655 Q-loop/lid; other site 862719004656 ABC transporter signature motif; other site 862719004657 Walker B; other site 862719004658 D-loop; other site 862719004659 H-loop/switch region; other site 862719004660 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 862719004661 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 862719004662 putative catalytic cysteine [active] 862719004663 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 862719004664 putative active site [active] 862719004665 metal binding site [ion binding]; metal-binding site 862719004666 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 862719004667 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719004668 ligand binding site [chemical binding]; other site 862719004669 flexible hinge region; other site 862719004670 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 862719004671 putative switch regulator; other site 862719004672 non-specific DNA interactions [nucleotide binding]; other site 862719004673 DNA binding site [nucleotide binding] 862719004674 sequence specific DNA binding site [nucleotide binding]; other site 862719004675 putative cAMP binding site [chemical binding]; other site 862719004676 Evidence 2b : Function of strongly homologous gene; Product type r : regulator 862719004677 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 862719004678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004679 active site 862719004680 phosphorylation site [posttranslational modification] 862719004681 intermolecular recognition site; other site 862719004682 dimerization interface [polypeptide binding]; other site 862719004683 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719004684 DNA binding residues [nucleotide binding] 862719004685 dimerization interface [polypeptide binding]; other site 862719004686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719004687 putative active site [active] 862719004688 heme pocket [chemical binding]; other site 862719004689 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719004690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719004691 putative active site [active] 862719004692 heme pocket [chemical binding]; other site 862719004693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719004694 dimer interface [polypeptide binding]; other site 862719004695 phosphorylation site [posttranslational modification] 862719004696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004697 ATP binding site [chemical binding]; other site 862719004698 Mg2+ binding site [ion binding]; other site 862719004699 G-X-G motif; other site 862719004700 UV-endonuclease UvdE; Region: UvdE; cl10036 862719004701 Helix-turn-helix domain; Region: HTH_36; pfam13730 862719004702 TIR domain; Region: TIR_2; pfam13676 862719004703 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719004704 Tetratricopeptide repeat; Region: TPR_10; pfam13374 862719004705 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719004706 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 862719004707 Walker A/P-loop; other site 862719004708 ATP binding site [chemical binding]; other site 862719004709 Q-loop/lid; other site 862719004710 ABC transporter signature motif; other site 862719004711 Walker B; other site 862719004712 D-loop; other site 862719004713 H-loop/switch region; other site 862719004714 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 862719004715 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004716 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719004717 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004718 TM-ABC transporter signature motif; other site 862719004719 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 862719004720 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 862719004721 putative ligand binding site [chemical binding]; other site 862719004722 xylose isomerase; Provisional; Region: PRK05474 862719004723 xylose isomerase; Region: xylose_isom_A; TIGR02630 862719004724 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 862719004725 N- and C-terminal domain interface [polypeptide binding]; other site 862719004726 D-xylulose kinase; Region: XylB; TIGR01312 862719004727 active site 862719004728 MgATP binding site [chemical binding]; other site 862719004729 catalytic site [active] 862719004730 metal binding site [ion binding]; metal-binding site 862719004731 xylulose binding site [chemical binding]; other site 862719004732 homodimer interface [polypeptide binding]; other site 862719004733 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719004734 DNA binding site [nucleotide binding] 862719004735 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 862719004736 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 862719004737 putative ligand binding site [chemical binding]; other site 862719004738 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 862719004739 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 862719004740 ATP binding site [chemical binding]; other site 862719004741 putative Mg++ binding site [ion binding]; other site 862719004742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719004743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719004744 LysR substrate binding domain; Region: LysR_substrate; pfam03466 862719004745 dimerization interface [polypeptide binding]; other site 862719004746 Uncharacterized conserved protein [Function unknown]; Region: COG2353 862719004747 NnrS protein; Region: NnrS; pfam05940 862719004748 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719004749 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 862719004750 ligand binding site [chemical binding]; other site 862719004751 flexible hinge region; other site 862719004752 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 862719004753 putative switch regulator; other site 862719004754 non-specific DNA interactions [nucleotide binding]; other site 862719004755 DNA binding site [nucleotide binding] 862719004756 sequence specific DNA binding site [nucleotide binding]; other site 862719004757 putative cAMP binding site [chemical binding]; other site 862719004758 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 862719004759 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 862719004760 oxidoreductase; Provisional; Region: PRK06128 862719004761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719004762 NAD(P) binding site [chemical binding]; other site 862719004763 active site 862719004764 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719004765 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719004766 TM-ABC transporter signature motif; other site 862719004767 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 862719004768 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 862719004769 Walker A/P-loop; other site 862719004770 ATP binding site [chemical binding]; other site 862719004771 Q-loop/lid; other site 862719004772 ABC transporter signature motif; other site 862719004773 Walker B; other site 862719004774 D-loop; other site 862719004775 H-loop/switch region; other site 862719004776 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 862719004777 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 862719004778 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 862719004779 putative ligand binding site [chemical binding]; other site 862719004780 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 862719004781 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 862719004782 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 862719004783 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 862719004784 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719004785 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719004786 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 862719004787 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 862719004788 carboxyltransferase (CT) interaction site; other site 862719004789 biotinylation site [posttranslational modification]; other site 862719004790 hypothetical protein; Provisional; Region: PRK12569 862719004791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719004792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719004793 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 862719004794 putative substrate binding pocket [chemical binding]; other site 862719004795 dimerization interface [polypeptide binding]; other site 862719004796 SCP-2 sterol transfer family; Region: SCP2; cl01225 862719004797 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 862719004798 Peptidase family U32; Region: Peptidase_U32; pfam01136 862719004799 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 862719004800 putative protease; Provisional; Region: PRK15447 862719004801 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 862719004802 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 862719004803 ApbE family; Region: ApbE; pfam02424 862719004804 NosL; Region: NosL; pfam05573 862719004805 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 862719004806 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862719004807 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 862719004808 Walker A/P-loop; other site 862719004809 ATP binding site [chemical binding]; other site 862719004810 Q-loop/lid; other site 862719004811 ABC transporter signature motif; other site 862719004812 Walker B; other site 862719004813 D-loop; other site 862719004814 H-loop/switch region; other site 862719004815 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 862719004816 nitrous-oxide reductase; Validated; Region: PRK02888 862719004817 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 862719004818 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 862719004819 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 862719004820 4Fe-4S binding domain; Region: Fer4_5; pfam12801 862719004821 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 862719004822 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 862719004823 active site 862719004824 catalytic residues [active] 862719004825 Evidence 2b : Function of strongly homologous gene; PubMedId : 7639719; Product type f : factor 862719004826 ferredoxin-type protein NapF; Region: napF; TIGR00402 862719004827 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 862719004828 NapD protein; Region: NapD; pfam03927 862719004829 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 862719004830 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 862719004831 [4Fe-4S] binding site [ion binding]; other site 862719004832 molybdopterin cofactor binding site; other site 862719004833 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 862719004834 molybdopterin cofactor binding site; other site 862719004835 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 862719004836 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 862719004837 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 862719004838 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 862719004839 ParB-like nuclease domain; Region: ParBc; pfam02195 862719004840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719004841 non-specific DNA binding site [nucleotide binding]; other site 862719004842 salt bridge; other site 862719004843 sequence-specific DNA binding site [nucleotide binding]; other site 862719004844 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719004845 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 862719004846 P-loop; other site 862719004847 Magnesium ion binding site [ion binding]; other site 862719004848 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719004849 Magnesium ion binding site [ion binding]; other site 862719004850 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 862719004851 DNA-binding site [nucleotide binding]; DNA binding site 862719004852 RNA-binding motif; other site 862719004853 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719004854 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719004855 P-loop; other site 862719004856 Magnesium ion binding site [ion binding]; other site 862719004857 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 862719004858 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862719004859 putative catalytic site [active] 862719004860 putative metal binding site [ion binding]; other site 862719004861 putative phosphate binding site [ion binding]; other site 862719004862 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862719004863 putative metal binding site [ion binding]; other site 862719004864 CheD chemotactic sensory transduction; Region: CheD; cl00810 862719004865 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 862719004866 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862719004867 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862719004868 phosphopeptide binding site; other site 862719004869 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 862719004870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719004871 putative substrate translocation pore; other site 862719004872 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 862719004873 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719004874 Histidine kinase; Region: HisKA_2; pfam07568 862719004875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719004876 ATP binding site [chemical binding]; other site 862719004877 Mg2+ binding site [ion binding]; other site 862719004878 G-X-G motif; other site 862719004879 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 862719004880 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719004881 substrate binding pocket [chemical binding]; other site 862719004882 membrane-bound complex binding site; other site 862719004883 hinge residues; other site 862719004884 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 862719004885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719004886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004887 dimer interface [polypeptide binding]; other site 862719004888 putative PBP binding loops; other site 862719004889 ABC-ATPase subunit interface; other site 862719004890 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719004891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719004892 dimer interface [polypeptide binding]; other site 862719004893 conserved gate region; other site 862719004894 putative PBP binding loops; other site 862719004895 ABC-ATPase subunit interface; other site 862719004896 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719004897 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 862719004898 Walker A/P-loop; other site 862719004899 ATP binding site [chemical binding]; other site 862719004900 Q-loop/lid; other site 862719004901 ABC transporter signature motif; other site 862719004902 Walker B; other site 862719004903 D-loop; other site 862719004904 H-loop/switch region; other site 862719004905 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 862719004906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719004907 active site 862719004908 phosphorylation site [posttranslational modification] 862719004909 intermolecular recognition site; other site 862719004910 dimerization interface [polypeptide binding]; other site 862719004911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719004912 DNA binding site [nucleotide binding] 862719004913 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719004914 dimerization interface [polypeptide binding]; other site 862719004915 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719004916 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719004917 dimer interface [polypeptide binding]; other site 862719004918 putative CheW interface [polypeptide binding]; other site 862719004919 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 862719004920 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719004921 substrate binding pocket [chemical binding]; other site 862719004922 membrane-bound complex binding site; other site 862719004923 hinge residues; other site 862719004924 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719004925 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719004926 Walker A/P-loop; other site 862719004927 ATP binding site [chemical binding]; other site 862719004928 Q-loop/lid; other site 862719004929 ABC transporter signature motif; other site 862719004930 Walker B; other site 862719004931 D-loop; other site 862719004932 H-loop/switch region; other site 862719004933 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719004934 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719004935 Walker A/P-loop; other site 862719004936 ATP binding site [chemical binding]; other site 862719004937 Q-loop/lid; other site 862719004938 ABC transporter signature motif; other site 862719004939 Walker B; other site 862719004940 D-loop; other site 862719004941 H-loop/switch region; other site 862719004942 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719004943 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719004944 TM-ABC transporter signature motif; other site 862719004945 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719004946 TM-ABC transporter signature motif; other site 862719004947 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 862719004948 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862719004949 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 862719004950 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 862719004951 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 862719004952 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719004953 dimer interface [polypeptide binding]; other site 862719004954 active site 862719004955 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 862719004956 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 862719004957 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 862719004958 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 862719004959 tetramer interface [polypeptide binding]; other site 862719004960 active site 862719004961 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 862719004962 heterodimer interface [polypeptide binding]; other site 862719004963 multimer interface [polypeptide binding]; other site 862719004964 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 862719004965 active site 862719004966 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 862719004967 heterodimer interface [polypeptide binding]; other site 862719004968 active site 862719004969 Cache domain; Region: Cache_1; pfam02743 862719004970 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719004971 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719004972 dimer interface [polypeptide binding]; other site 862719004973 putative CheW interface [polypeptide binding]; other site 862719004974 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719004975 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 862719004976 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 862719004977 DctM-like transporters; Region: DctM; pfam06808 862719004978 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 862719004979 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 862719004980 ATP-binding site [chemical binding]; other site 862719004981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 862719004982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719004983 DNA binding site [nucleotide binding] 862719004984 domain linker motif; other site 862719004985 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 862719004986 putative dimerization interface [polypeptide binding]; other site 862719004987 putative ligand binding site [chemical binding]; other site 862719004988 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719004989 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719004990 dimerization interface [polypeptide binding]; other site 862719004991 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719004992 dimer interface [polypeptide binding]; other site 862719004993 putative CheW interface [polypeptide binding]; other site 862719004994 short chain dehydrogenase; Provisional; Region: PRK06500 862719004995 classical (c) SDRs; Region: SDR_c; cd05233 862719004996 NAD(P) binding site [chemical binding]; other site 862719004997 active site 862719004998 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 862719004999 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 862719005000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862719005001 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 862719005002 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 862719005003 tetramer interface [polypeptide binding]; other site 862719005004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719005005 catalytic residue [active] 862719005006 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 862719005007 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862719005008 RNA binding surface [nucleotide binding]; other site 862719005009 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 862719005010 active site 862719005011 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 862719005012 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 862719005013 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719005014 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719005015 DNA binding residues [nucleotide binding] 862719005016 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 862719005017 LysE type translocator; Region: LysE; cl00565 862719005018 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 862719005019 putative active site pocket [active] 862719005020 dimerization interface [polypeptide binding]; other site 862719005021 putative catalytic residue [active] 862719005022 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 862719005023 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 862719005024 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 862719005025 tetramer interface [polypeptide binding]; other site 862719005026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719005027 catalytic residue [active] 862719005028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719005029 Coenzyme A binding pocket [chemical binding]; other site 862719005030 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 862719005031 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 862719005032 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719005033 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 862719005034 putative substrate binding pocket [chemical binding]; other site 862719005035 putative dimerization interface [polypeptide binding]; other site 862719005036 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719005037 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862719005038 active site 862719005039 catalytic tetrad [active] 862719005040 hypothetical protein; Validated; Region: PRK09104 862719005041 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 862719005042 metal binding site [ion binding]; metal-binding site 862719005043 putative dimer interface [polypeptide binding]; other site 862719005044 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719005045 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719005046 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 862719005047 P-loop; other site 862719005048 Magnesium ion binding site [ion binding]; other site 862719005049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719005050 dimerization interface [polypeptide binding]; other site 862719005051 putative DNA binding site [nucleotide binding]; other site 862719005052 putative Zn2+ binding site [ion binding]; other site 862719005053 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 862719005054 Low molecular weight phosphatase family; Region: LMWPc; cd00115 862719005055 active site 862719005056 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 862719005057 ArsC family; Region: ArsC; pfam03960 862719005058 catalytic residues [active] 862719005059 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 862719005060 Sodium Bile acid symporter family; Region: SBF; cl17470 862719005061 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 862719005062 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 862719005063 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 862719005064 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 862719005065 tetrameric interface [polypeptide binding]; other site 862719005066 NAD binding site [chemical binding]; other site 862719005067 catalytic residues [active] 862719005068 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719005069 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 862719005070 substrate binding pocket [chemical binding]; other site 862719005071 FAD binding site [chemical binding]; other site 862719005072 catalytic base [active] 862719005073 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 862719005074 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 862719005075 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 862719005076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719005077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719005078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719005079 dimerization interface [polypeptide binding]; other site 862719005080 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 862719005081 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : putative factor 862719005082 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 862719005083 Caspase domain; Region: Peptidase_C14; pfam00656 862719005084 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 862719005085 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 862719005086 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862719005087 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719005088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719005089 Walker A/P-loop; other site 862719005090 ATP binding site [chemical binding]; other site 862719005091 Q-loop/lid; other site 862719005092 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862719005093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719005094 ABC transporter signature motif; other site 862719005095 Walker B; other site 862719005096 D-loop; other site 862719005097 H-loop/switch region; other site 862719005098 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719005099 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719005100 ligand binding site [chemical binding]; other site 862719005101 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 862719005102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719005103 Walker A/P-loop; other site 862719005104 ATP binding site [chemical binding]; other site 862719005105 Q-loop/lid; other site 862719005106 ABC transporter signature motif; other site 862719005107 Walker B; other site 862719005108 D-loop; other site 862719005109 H-loop/switch region; other site 862719005110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719005111 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719005112 Walker A/P-loop; other site 862719005113 ATP binding site [chemical binding]; other site 862719005114 Q-loop/lid; other site 862719005115 ABC transporter signature motif; other site 862719005116 Walker B; other site 862719005117 D-loop; other site 862719005118 H-loop/switch region; other site 862719005119 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719005120 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719005121 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 862719005122 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719005123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719005124 dimer interface [polypeptide binding]; other site 862719005125 conserved gate region; other site 862719005126 ABC-ATPase subunit interface; other site 862719005127 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 862719005128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719005129 dimer interface [polypeptide binding]; other site 862719005130 conserved gate region; other site 862719005131 putative PBP binding loops; other site 862719005132 ABC-ATPase subunit interface; other site 862719005133 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 862719005134 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 862719005135 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 862719005136 putative ADP-binding pocket [chemical binding]; other site 862719005137 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719005138 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719005139 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719005140 catalytic core [active] 862719005141 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 862719005142 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719005143 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 862719005144 NodB motif; other site 862719005145 putative active site [active] 862719005146 putative catalytic site [active] 862719005147 putative Zn binding site [ion binding]; other site 862719005148 Abi-like protein; Region: Abi_2; pfam07751 862719005149 Helix-turn-helix domain; Region: HTH_36; pfam13730 862719005150 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 862719005151 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 862719005152 Calx-beta domain; Region: Calx-beta; pfam03160 862719005153 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719005154 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 862719005155 Walker A/P-loop; other site 862719005156 ATP binding site [chemical binding]; other site 862719005157 Q-loop/lid; other site 862719005158 ABC transporter signature motif; other site 862719005159 Walker B; other site 862719005160 D-loop; other site 862719005161 H-loop/switch region; other site 862719005162 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719005163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719005164 dimer interface [polypeptide binding]; other site 862719005165 conserved gate region; other site 862719005166 putative PBP binding loops; other site 862719005167 ABC-ATPase subunit interface; other site 862719005168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719005169 dimer interface [polypeptide binding]; other site 862719005170 conserved gate region; other site 862719005171 ABC-ATPase subunit interface; other site 862719005172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719005173 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719005174 substrate binding pocket [chemical binding]; other site 862719005175 membrane-bound complex binding site; other site 862719005176 hinge residues; other site 862719005177 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862719005178 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 862719005179 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 862719005180 pyruvate kinase; Provisional; Region: PRK06247 862719005181 domain interfaces; other site 862719005182 active site 862719005183 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719005184 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 862719005185 AsnC family; Region: AsnC_trans_reg; pfam01037 862719005186 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862719005187 active site 862719005188 Right handed beta helix region; Region: Beta_helix; pfam13229 862719005189 Right handed beta helix region; Region: Beta_helix; pfam13229 862719005190 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 862719005191 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719005192 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862719005193 active site 862719005194 catalytic tetrad [active] 862719005195 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 862719005196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 862719005197 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719005198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719005199 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 862719005200 dimerization interface [polypeptide binding]; other site 862719005201 substrate binding pocket [chemical binding]; other site 862719005202 Initiator Replication protein; Region: Rep_3; pfam01051 862719005203 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 862719005204 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 862719005205 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 862719005206 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 862719005207 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 862719005208 putative acyl-acceptor binding pocket; other site 862719005209 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 862719005210 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 862719005211 Walker A/P-loop; other site 862719005212 ATP binding site [chemical binding]; other site 862719005213 Q-loop/lid; other site 862719005214 ABC transporter signature motif; other site 862719005215 Walker B; other site 862719005216 D-loop; other site 862719005217 H-loop/switch region; other site 862719005218 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 862719005219 Uncharacterized conserved protein [Function unknown]; Region: COG1434 862719005220 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 862719005221 putative active site [active] 862719005222 Hemin uptake protein hemP; Region: hemP; pfam10636 862719005223 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862719005224 metal-binding site [ion binding] 862719005225 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 862719005226 putative hydrophobic ligand binding site [chemical binding]; other site 862719005227 protein interface [polypeptide binding]; other site 862719005228 gate; other site 862719005229 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 862719005230 Coenzyme A transferase; Region: CoA_trans; cl17247 862719005231 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 862719005232 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 862719005233 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 862719005234 NAD binding site [chemical binding]; other site 862719005235 homotetramer interface [polypeptide binding]; other site 862719005236 homodimer interface [polypeptide binding]; other site 862719005237 substrate binding site [chemical binding]; other site 862719005238 active site 862719005239 Ribbon-helix-helix domain; Region: RHH_4; cl01775 862719005240 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719005241 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719005242 ligand binding site [chemical binding]; other site 862719005243 flexible hinge region; other site 862719005244 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 862719005245 non-specific DNA interactions [nucleotide binding]; other site 862719005246 DNA binding site [nucleotide binding] 862719005247 sequence specific DNA binding site [nucleotide binding]; other site 862719005248 putative cAMP binding site [chemical binding]; other site 862719005249 Uncharacterized conserved protein [Function unknown]; Region: COG3482 862719005250 Uncharacterized conserved protein [Function unknown]; Region: COG1944 862719005251 YcaO-like family; Region: YcaO; pfam02624 862719005252 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719005253 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719005254 cyclase homology domain; Region: CHD; cd07302 862719005255 nucleotidyl binding site; other site 862719005256 metal binding site [ion binding]; metal-binding site 862719005257 dimer interface [polypeptide binding]; other site 862719005258 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 862719005259 AAA ATPase domain; Region: AAA_16; pfam13191 862719005260 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 862719005261 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 862719005262 dimerization interface [polypeptide binding]; other site 862719005263 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 862719005264 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862719005265 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 862719005266 putative active site [active] 862719005267 O-Antigen ligase; Region: Wzy_C; pfam04932 862719005268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719005269 Coenzyme A binding pocket [chemical binding]; other site 862719005270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 862719005271 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 862719005272 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 862719005273 oligomeric interface; other site 862719005274 putative active site [active] 862719005275 homodimer interface [polypeptide binding]; other site 862719005276 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 862719005277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719005278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719005279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719005280 dimerization interface [polypeptide binding]; other site 862719005281 Domain of unknown function (DUF897); Region: DUF897; cl01312 862719005282 Predicted acetyltransferase [General function prediction only]; Region: COG2388 862719005283 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 862719005284 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 862719005285 active site 862719005286 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 862719005287 active site 862719005288 tetramer interface; other site 862719005289 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 862719005290 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 862719005291 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 862719005292 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 862719005293 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 862719005294 active site 862719005295 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 862719005296 substrate binding site [chemical binding]; other site 862719005297 metal binding site [ion binding]; metal-binding site 862719005298 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 862719005299 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 862719005300 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 862719005301 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 862719005302 Walker A/P-loop; other site 862719005303 ATP binding site [chemical binding]; other site 862719005304 Q-loop/lid; other site 862719005305 ABC transporter signature motif; other site 862719005306 Walker B; other site 862719005307 D-loop; other site 862719005308 H-loop/switch region; other site 862719005309 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 862719005310 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 862719005311 Walker A/P-loop; other site 862719005312 ATP binding site [chemical binding]; other site 862719005313 Q-loop/lid; other site 862719005314 ABC transporter signature motif; other site 862719005315 Walker B; other site 862719005316 D-loop; other site 862719005317 H-loop/switch region; other site 862719005318 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 862719005319 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 862719005320 HlyD family secretion protein; Region: HlyD; pfam00529 862719005321 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719005322 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719005323 thioredoxin 2; Provisional; Region: PRK10996 862719005324 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 862719005325 catalytic residues [active] 862719005326 Heavy-metal resistance; Region: Metal_resist; pfam13801 862719005327 RNA polymerase sigma factor; Reviewed; Region: PRK05602 862719005328 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719005329 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719005330 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 862719005331 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 862719005332 Protein export membrane protein; Region: SecD_SecF; cl14618 862719005333 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719005334 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719005335 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719005336 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 862719005337 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 862719005338 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862719005339 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719005340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719005341 DNA-binding site [nucleotide binding]; DNA binding site 862719005342 FCD domain; Region: FCD; pfam07729 862719005343 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 862719005344 active site 862719005345 ATP binding site [chemical binding]; other site 862719005346 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 862719005347 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719005348 inhibitor-cofactor binding pocket; inhibition site 862719005349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719005350 catalytic residue [active] 862719005351 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 862719005352 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719005353 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 862719005354 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719005355 FAD binding site [chemical binding]; other site 862719005356 substrate binding pocket [chemical binding]; other site 862719005357 catalytic base [active] 862719005358 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719005359 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719005360 dimer interface [polypeptide binding]; other site 862719005361 putative CheW interface [polypeptide binding]; other site 862719005362 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719005363 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719005364 Walker A/P-loop; other site 862719005365 ATP binding site [chemical binding]; other site 862719005366 Q-loop/lid; other site 862719005367 ABC transporter signature motif; other site 862719005368 Walker B; other site 862719005369 D-loop; other site 862719005370 H-loop/switch region; other site 862719005371 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719005372 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719005373 Walker A/P-loop; other site 862719005374 ATP binding site [chemical binding]; other site 862719005375 Q-loop/lid; other site 862719005376 ABC transporter signature motif; other site 862719005377 Walker B; other site 862719005378 D-loop; other site 862719005379 H-loop/switch region; other site 862719005380 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719005381 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719005382 TM-ABC transporter signature motif; other site 862719005383 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719005384 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719005385 TM-ABC transporter signature motif; other site 862719005386 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 862719005387 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 862719005388 hexamer interface [polypeptide binding]; other site 862719005389 ligand binding site [chemical binding]; other site 862719005390 putative active site [active] 862719005391 NAD(P) binding site [chemical binding]; other site 862719005392 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719005393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719005394 putative DNA binding site [nucleotide binding]; other site 862719005395 putative Zn2+ binding site [ion binding]; other site 862719005396 AsnC family; Region: AsnC_trans_reg; pfam01037 862719005397 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 862719005398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719005399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719005400 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719005401 dimerization interface [polypeptide binding]; other site 862719005402 DNA polymerase IV; Provisional; Region: PRK02794 862719005403 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 862719005404 active site 862719005405 DNA binding site [nucleotide binding] 862719005406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719005407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005408 active site 862719005409 phosphorylation site [posttranslational modification] 862719005410 intermolecular recognition site; other site 862719005411 dimerization interface [polypeptide binding]; other site 862719005412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719005413 DNA binding residues [nucleotide binding] 862719005414 dimerization interface [polypeptide binding]; other site 862719005415 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 862719005416 Na binding site [ion binding]; other site 862719005417 PAS fold; Region: PAS_7; pfam12860 862719005418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719005419 putative active site [active] 862719005420 heme pocket [chemical binding]; other site 862719005421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719005422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719005423 dimer interface [polypeptide binding]; other site 862719005424 phosphorylation site [posttranslational modification] 862719005425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005426 ATP binding site [chemical binding]; other site 862719005427 Mg2+ binding site [ion binding]; other site 862719005428 G-X-G motif; other site 862719005429 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719005430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 862719005431 active site 862719005432 phosphorylation site [posttranslational modification] 862719005433 intermolecular recognition site; other site 862719005434 dimerization interface [polypeptide binding]; other site 862719005435 tellurium resistance terB-like protein; Region: terB_like; cd07177 862719005436 metal binding site [ion binding]; metal-binding site 862719005437 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719005438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719005439 dimer interface [polypeptide binding]; other site 862719005440 phosphorylation site [posttranslational modification] 862719005441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005442 ATP binding site [chemical binding]; other site 862719005443 Mg2+ binding site [ion binding]; other site 862719005444 G-X-G motif; other site 862719005445 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005447 active site 862719005448 phosphorylation site [posttranslational modification] 862719005449 intermolecular recognition site; other site 862719005450 dimerization interface [polypeptide binding]; other site 862719005451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005452 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005453 active site 862719005454 phosphorylation site [posttranslational modification] 862719005455 intermolecular recognition site; other site 862719005456 dimerization interface [polypeptide binding]; other site 862719005457 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 862719005458 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 862719005459 diaminopimelate decarboxylase; Region: lysA; TIGR01048 862719005460 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 862719005461 active site 862719005462 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862719005463 substrate binding site [chemical binding]; other site 862719005464 catalytic residues [active] 862719005465 dimer interface [polypeptide binding]; other site 862719005466 argininosuccinate lyase; Provisional; Region: PRK00855 862719005467 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 862719005468 active sites [active] 862719005469 tetramer interface [polypeptide binding]; other site 862719005470 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 862719005471 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 862719005472 catalytic residues [active] 862719005473 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719005474 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719005475 ligand binding site [chemical binding]; other site 862719005476 flexible hinge region; other site 862719005477 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719005478 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719005479 ligand binding site [chemical binding]; other site 862719005480 flexible hinge region; other site 862719005481 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719005482 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719005483 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719005484 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862719005485 active site 862719005486 catalytic tetrad [active] 862719005487 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 862719005488 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 862719005489 MOFRL family; Region: MOFRL; pfam05161 862719005490 tartronate semialdehyde reductase; Provisional; Region: PRK15059 862719005491 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 862719005492 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 862719005493 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 862719005494 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 862719005495 active site 862719005496 FMN binding site [chemical binding]; other site 862719005497 2,4-decadienoyl-CoA binding site; other site 862719005498 catalytic residue [active] 862719005499 4Fe-4S cluster binding site [ion binding]; other site 862719005500 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 862719005501 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719005502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719005503 DNA-binding site [nucleotide binding]; DNA binding site 862719005504 FCD domain; Region: FCD; pfam07729 862719005505 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719005506 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 862719005507 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 862719005508 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 862719005509 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719005510 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 862719005511 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 862719005512 DctM-like transporters; Region: DctM; pfam06808 862719005513 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 862719005514 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 862719005515 putative FMN binding site [chemical binding]; other site 862719005516 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 862719005517 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 862719005518 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 862719005519 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 862719005520 active site 862719005521 SAM binding site [chemical binding]; other site 862719005522 homodimer interface [polypeptide binding]; other site 862719005523 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 862719005524 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 862719005525 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 862719005526 active site 862719005527 SAM binding site [chemical binding]; other site 862719005528 homodimer interface [polypeptide binding]; other site 862719005529 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 862719005530 active site 862719005531 putative homodimer interface [polypeptide binding]; other site 862719005532 SAM binding site [chemical binding]; other site 862719005533 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 862719005534 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 862719005535 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 862719005536 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 862719005537 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 862719005538 active site 862719005539 SAM binding site [chemical binding]; other site 862719005540 homodimer interface [polypeptide binding]; other site 862719005541 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 862719005542 active site 862719005543 SAM binding site [chemical binding]; other site 862719005544 homodimer interface [polypeptide binding]; other site 862719005545 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 862719005546 Precorrin-8X methylmutase; Region: CbiC; pfam02570 862719005547 precorrin-3B synthase; Region: CobG; TIGR02435 862719005548 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 862719005549 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 862719005550 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 862719005551 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 862719005552 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 862719005553 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 862719005554 Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490 862719005555 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 862719005556 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719005557 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719005558 Walker A/P-loop; other site 862719005559 ATP binding site [chemical binding]; other site 862719005560 Q-loop/lid; other site 862719005561 ABC transporter signature motif; other site 862719005562 Walker B; other site 862719005563 D-loop; other site 862719005564 H-loop/switch region; other site 862719005565 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719005566 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719005567 Walker A/P-loop; other site 862719005568 ATP binding site [chemical binding]; other site 862719005569 Q-loop/lid; other site 862719005570 ABC transporter signature motif; other site 862719005571 Walker B; other site 862719005572 D-loop; other site 862719005573 H-loop/switch region; other site 862719005574 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 862719005575 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719005576 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 862719005577 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719005578 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 862719005579 acyl-activating enzyme (AAE) consensus motif; other site 862719005580 AMP binding site [chemical binding]; other site 862719005581 active site 862719005582 CoA binding site [chemical binding]; other site 862719005583 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 862719005584 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719005585 dimer interface [polypeptide binding]; other site 862719005586 active site 862719005587 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 862719005588 CoenzymeA binding site [chemical binding]; other site 862719005589 subunit interaction site [polypeptide binding]; other site 862719005590 PHB binding site; other site 862719005591 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 862719005592 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 862719005593 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719005594 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719005595 enoyl-CoA hydratase; Provisional; Region: PRK08140 862719005596 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719005597 substrate binding site [chemical binding]; other site 862719005598 oxyanion hole (OAH) forming residues; other site 862719005599 trimer interface [polypeptide binding]; other site 862719005600 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 862719005601 Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Region: ALDH_PAD-PaaZ; cd07127 862719005602 NADP binding site [chemical binding]; other site 862719005603 catalytic residues [active] 862719005604 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 862719005605 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 862719005606 FAD binding pocket [chemical binding]; other site 862719005607 FAD binding motif [chemical binding]; other site 862719005608 phosphate binding motif [ion binding]; other site 862719005609 beta-alpha-beta structure motif; other site 862719005610 NAD(p) ribose binding residues [chemical binding]; other site 862719005611 NAD binding pocket [chemical binding]; other site 862719005612 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 862719005613 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719005614 catalytic loop [active] 862719005615 iron binding site [ion binding]; other site 862719005616 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 862719005617 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 862719005618 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 862719005619 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 862719005620 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 862719005621 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 862719005622 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719005623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719005624 dimerization interface [polypeptide binding]; other site 862719005625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719005626 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 862719005627 dimer interface [polypeptide binding]; other site 862719005628 phosphorylation site [posttranslational modification] 862719005629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005630 ATP binding site [chemical binding]; other site 862719005631 Mg2+ binding site [ion binding]; other site 862719005632 G-X-G motif; other site 862719005633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005634 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005635 active site 862719005636 phosphorylation site [posttranslational modification] 862719005637 intermolecular recognition site; other site 862719005638 dimerization interface [polypeptide binding]; other site 862719005639 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862719005640 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719005641 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 862719005642 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 862719005643 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 862719005644 active site 862719005645 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 862719005646 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 862719005647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719005648 FeS/SAM binding site; other site 862719005649 Transcriptional regulators [Transcription]; Region: MarR; COG1846 862719005650 MarR family; Region: MarR_2; pfam12802 862719005651 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 862719005652 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 862719005653 cell density-dependent motility repressor; Provisional; Region: PRK10082 862719005654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719005655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719005656 dimerization interface [polypeptide binding]; other site 862719005657 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 862719005658 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 862719005659 putative active site pocket [active] 862719005660 metal binding site [ion binding]; metal-binding site 862719005661 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 862719005662 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 862719005663 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 862719005664 dimerization interface [polypeptide binding]; other site 862719005665 active site 862719005666 L-aspartate oxidase; Provisional; Region: PRK06175 862719005667 L-aspartate oxidase; Provisional; Region: PRK07512 862719005668 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 862719005669 quinolinate synthetase; Provisional; Region: PRK09375 862719005670 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 862719005671 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 862719005672 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 862719005673 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 862719005674 [4Fe-4S] binding site [ion binding]; other site 862719005675 molybdopterin cofactor binding site; other site 862719005676 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 862719005677 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 862719005678 molybdopterin cofactor binding site; other site 862719005679 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 862719005680 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 862719005681 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 862719005682 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 862719005683 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 862719005684 NAD(P) binding site [chemical binding]; other site 862719005685 catalytic residues [active] 862719005686 Protein of unknown function (DUF779); Region: DUF779; cl01432 862719005687 Uncharacterized conserved protein [Function unknown]; Region: COG3287 862719005688 FIST N domain; Region: FIST; pfam08495 862719005689 FIST C domain; Region: FIST_C; pfam10442 862719005690 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719005691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719005692 dimer interface [polypeptide binding]; other site 862719005693 phosphorylation site [posttranslational modification] 862719005694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005695 ATP binding site [chemical binding]; other site 862719005696 Mg2+ binding site [ion binding]; other site 862719005697 G-X-G motif; other site 862719005698 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005700 active site 862719005701 phosphorylation site [posttranslational modification] 862719005702 intermolecular recognition site; other site 862719005703 dimerization interface [polypeptide binding]; other site 862719005704 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 862719005705 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 862719005706 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 862719005707 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719005708 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719005709 metal binding site [ion binding]; metal-binding site 862719005710 active site 862719005711 I-site; other site 862719005712 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719005713 LysE type translocator; Region: LysE; cl00565 862719005714 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 862719005715 metal ion-dependent adhesion site (MIDAS); other site 862719005716 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 862719005717 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 862719005718 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 862719005719 ethanolamine permease; Region: 2A0305; TIGR00908 862719005720 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 862719005721 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 862719005722 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 862719005723 putative catalytic site [active] 862719005724 putative metal binding site [ion binding]; other site 862719005725 putative phosphate binding site [ion binding]; other site 862719005726 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 862719005727 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 862719005728 putative active site [active] 862719005729 putative active site [active] 862719005730 catalytic site [active] 862719005731 catalytic site [active] 862719005732 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 862719005733 PLD-like domain; Region: PLDc_2; pfam13091 862719005734 putative active site [active] 862719005735 catalytic site [active] 862719005736 Uncharacterized conserved protein [Function unknown]; Region: COG0398 862719005737 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 862719005738 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719005739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719005740 ABC-ATPase subunit interface; other site 862719005741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719005742 Walker A/P-loop; other site 862719005743 ATP binding site [chemical binding]; other site 862719005744 Q-loop/lid; other site 862719005745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719005746 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 862719005747 Walker A/P-loop; other site 862719005748 ATP binding site [chemical binding]; other site 862719005749 Q-loop/lid; other site 862719005750 ABC transporter signature motif; other site 862719005751 Walker B; other site 862719005752 D-loop; other site 862719005753 H-loop/switch region; other site 862719005754 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719005755 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 862719005756 DNA-binding site [nucleotide binding]; DNA binding site 862719005757 RNA-binding motif; other site 862719005758 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 862719005759 DNA-binding site [nucleotide binding]; DNA binding site 862719005760 RNA-binding motif; other site 862719005761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 862719005762 SEC-C motif; Region: SEC-C; pfam02810 862719005763 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 862719005764 RNA/DNA hybrid binding site [nucleotide binding]; other site 862719005765 active site 862719005766 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 862719005767 DNA methylase; Region: N6_N4_Mtase; pfam01555 862719005768 Dihydroneopterin aldolase; Region: FolB; smart00905 862719005769 active site 862719005770 ornithine cyclodeaminase; Validated; Region: PRK07340 862719005771 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 862719005772 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 862719005773 active site 862719005774 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 862719005775 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719005776 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 862719005777 ATP binding site [chemical binding]; other site 862719005778 active site 862719005779 substrate binding site [chemical binding]; other site 862719005780 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 862719005781 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 862719005782 C-terminal peptidase (prc); Region: prc; TIGR00225 862719005783 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 862719005784 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 862719005785 protein binding site [polypeptide binding]; other site 862719005786 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 862719005787 Catalytic dyad [active] 862719005788 Bacterial sugar transferase; Region: Bac_transf; pfam02397 862719005789 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 862719005790 dimerization interface [polypeptide binding]; other site 862719005791 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 862719005792 ATP binding site [chemical binding]; other site 862719005793 HupF/HypC family; Region: HupF_HypC; pfam01455 862719005794 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 862719005795 G1 box; other site 862719005796 GTP/Mg2+ binding site [chemical binding]; other site 862719005797 G2 box; other site 862719005798 Switch I region; other site 862719005799 Switch II region; other site 862719005800 G4 box; other site 862719005801 G5 box; other site 862719005802 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 862719005803 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 862719005804 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 862719005805 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 862719005806 HutD; Region: HutD; pfam05962 862719005807 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 862719005808 beta-galactosidase; Region: BGL; TIGR03356 862719005809 xanthine permease; Region: pbuX; TIGR03173 862719005810 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719005811 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719005812 aromatic amino acid exporter; Provisional; Region: PRK11689 862719005813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719005814 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 862719005815 Serine hydrolase; Region: Ser_hydrolase; cl17834 862719005816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719005817 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 862719005818 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 862719005819 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719005820 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 862719005821 putative DNA binding site [nucleotide binding]; other site 862719005822 putative Zn2+ binding site [ion binding]; other site 862719005823 AsnC family; Region: AsnC_trans_reg; pfam01037 862719005824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 862719005825 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 862719005826 NnrS protein; Region: NnrS; pfam05940 862719005827 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005829 active site 862719005830 phosphorylation site [posttranslational modification] 862719005831 intermolecular recognition site; other site 862719005832 dimerization interface [polypeptide binding]; other site 862719005833 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719005834 PAS domain; Region: PAS; smart00091 862719005835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719005836 dimer interface [polypeptide binding]; other site 862719005837 phosphorylation site [posttranslational modification] 862719005838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005839 ATP binding site [chemical binding]; other site 862719005840 Mg2+ binding site [ion binding]; other site 862719005841 G-X-G motif; other site 862719005842 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005844 active site 862719005845 phosphorylation site [posttranslational modification] 862719005846 intermolecular recognition site; other site 862719005847 dimerization interface [polypeptide binding]; other site 862719005848 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 862719005849 Predicted membrane protein [Function unknown]; Region: COG3748 862719005850 Protein of unknown function (DUF989); Region: DUF989; pfam06181 862719005851 Cytochrome c; Region: Cytochrom_C; pfam00034 862719005852 guanine deaminase; Provisional; Region: PRK09228 862719005853 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 862719005854 active site 862719005855 Predicted membrane protein [Function unknown]; Region: COG1971 862719005856 Domain of unknown function DUF; Region: DUF204; pfam02659 862719005857 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 862719005858 Putative transcription activator [Transcription]; Region: TenA; COG0819 862719005859 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 862719005860 ABC-2 type transporter; Region: ABC2_membrane; cl17235 862719005861 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 862719005862 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 862719005863 Walker A/P-loop; other site 862719005864 ATP binding site [chemical binding]; other site 862719005865 Q-loop/lid; other site 862719005866 ABC transporter signature motif; other site 862719005867 Walker B; other site 862719005868 D-loop; other site 862719005869 H-loop/switch region; other site 862719005870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719005871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005872 ATP binding site [chemical binding]; other site 862719005873 Mg2+ binding site [ion binding]; other site 862719005874 G-X-G motif; other site 862719005875 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 862719005876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005877 active site 862719005878 phosphorylation site [posttranslational modification] 862719005879 intermolecular recognition site; other site 862719005880 dimerization interface [polypeptide binding]; other site 862719005881 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 862719005882 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 862719005883 Protein of unknown function DUF86; Region: DUF86; cl01031 862719005884 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 862719005885 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719005886 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719005887 ligand binding site [chemical binding]; other site 862719005888 flexible hinge region; other site 862719005889 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 862719005890 non-specific DNA interactions [nucleotide binding]; other site 862719005891 DNA binding site [nucleotide binding] 862719005892 sequence specific DNA binding site [nucleotide binding]; other site 862719005893 putative cAMP binding site [chemical binding]; other site 862719005894 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 862719005895 Chain length determinant protein; Region: Wzz; pfam02706 862719005896 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 862719005897 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 862719005898 Nucleotide binding site [chemical binding]; other site 862719005899 P loop; other site 862719005900 DTAP/Switch II; other site 862719005901 Switch I; other site 862719005902 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 862719005903 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 862719005904 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 862719005905 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 862719005906 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 862719005907 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 862719005908 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719005909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005910 NAD(P) binding site [chemical binding]; other site 862719005911 active site 862719005912 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 862719005913 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 862719005914 NADP binding site [chemical binding]; other site 862719005915 active site 862719005916 putative substrate binding site [chemical binding]; other site 862719005917 putative glycosyl transferase; Provisional; Region: PRK10307 862719005918 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 862719005919 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719005920 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719005921 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719005922 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719005923 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719005924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719005925 putative DNA binding site [nucleotide binding]; other site 862719005926 putative Zn2+ binding site [ion binding]; other site 862719005927 AsnC family; Region: AsnC_trans_reg; pfam01037 862719005928 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 862719005929 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 862719005930 dimer interface [polypeptide binding]; other site 862719005931 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 862719005932 active site 862719005933 Fe binding site [ion binding]; other site 862719005934 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 862719005935 Right handed beta helix region; Region: Beta_helix; pfam13229 862719005936 Phytochelatin synthase; Region: Phytochelatin; pfam05023 862719005937 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 862719005938 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 862719005939 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 862719005940 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 862719005941 putative NAD(P) binding site [chemical binding]; other site 862719005942 active site 862719005943 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 862719005944 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 862719005945 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 862719005946 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 862719005947 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 862719005948 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 862719005949 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 862719005950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719005951 short chain dehydrogenase; Provisional; Region: PRK06101 862719005952 NAD(P) binding site [chemical binding]; other site 862719005953 active site 862719005954 SnoaL-like domain; Region: SnoaL_2; pfam12680 862719005955 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 862719005956 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 862719005957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862719005958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719005959 S-adenosylmethionine binding site [chemical binding]; other site 862719005960 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 862719005961 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 862719005962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862719005963 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 862719005964 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719005965 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719005966 DNA binding residues [nucleotide binding] 862719005967 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 862719005968 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 862719005969 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719005970 HAMP domain; Region: HAMP; pfam00672 862719005971 dimerization interface [polypeptide binding]; other site 862719005972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719005973 dimer interface [polypeptide binding]; other site 862719005974 putative CheW interface [polypeptide binding]; other site 862719005975 PilZ domain; Region: PilZ; pfam07238 862719005976 PAS domain S-box; Region: sensory_box; TIGR00229 862719005977 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719005978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719005979 putative active site [active] 862719005980 heme pocket [chemical binding]; other site 862719005981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719005982 dimer interface [polypeptide binding]; other site 862719005983 phosphorylation site [posttranslational modification] 862719005984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719005985 ATP binding site [chemical binding]; other site 862719005986 Mg2+ binding site [ion binding]; other site 862719005987 G-X-G motif; other site 862719005988 Response regulator receiver domain; Region: Response_reg; pfam00072 862719005989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719005990 active site 862719005991 phosphorylation site [posttranslational modification] 862719005992 intermolecular recognition site; other site 862719005993 dimerization interface [polypeptide binding]; other site 862719005994 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719005995 putative binding surface; other site 862719005996 active site 862719005997 cheY-homologous receiver domain; Region: REC; smart00448 862719005998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719005999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006000 active site 862719006001 phosphorylation site [posttranslational modification] 862719006002 intermolecular recognition site; other site 862719006003 dimerization interface [polypeptide binding]; other site 862719006004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719006005 DNA binding residues [nucleotide binding] 862719006006 dimerization interface [polypeptide binding]; other site 862719006007 Winged helix-turn helix; Region: HTH_29; pfam13551 862719006008 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719006009 Homeodomain-like domain; Region: HTH_32; pfam13565 862719006010 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719006011 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006013 active site 862719006014 phosphorylation site [posttranslational modification] 862719006015 intermolecular recognition site; other site 862719006016 dimerization interface [polypeptide binding]; other site 862719006017 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 862719006018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006019 active site 862719006020 phosphorylation site [posttranslational modification] 862719006021 intermolecular recognition site; other site 862719006022 dimerization interface [polypeptide binding]; other site 862719006023 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719006024 Zn2+ binding site [ion binding]; other site 862719006025 Mg2+ binding site [ion binding]; other site 862719006026 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 862719006027 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 862719006028 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 862719006029 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 862719006030 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 862719006031 EamA-like transporter family; Region: EamA; pfam00892 862719006032 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 862719006033 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 862719006034 putative active site [active] 862719006035 putative PHP Thumb interface [polypeptide binding]; other site 862719006036 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 862719006037 generic binding surface II; other site 862719006038 generic binding surface I; other site 862719006039 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 862719006040 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 862719006041 Walker A motif/ATP binding site; other site 862719006042 Walker B motif; other site 862719006043 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719006044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006045 active site 862719006046 phosphorylation site [posttranslational modification] 862719006047 intermolecular recognition site; other site 862719006048 dimerization interface [polypeptide binding]; other site 862719006049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719006050 DNA binding site [nucleotide binding] 862719006051 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 862719006052 DNA-binding site [nucleotide binding]; DNA binding site 862719006053 RNA-binding motif; other site 862719006054 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 862719006055 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 862719006056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719006057 S-adenosylmethionine binding site [chemical binding]; other site 862719006058 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 862719006059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006060 active site 862719006061 phosphorylation site [posttranslational modification] 862719006062 intermolecular recognition site; other site 862719006063 dimerization interface [polypeptide binding]; other site 862719006064 CheB methylesterase; Region: CheB_methylest; pfam01339 862719006065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006066 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006067 active site 862719006068 phosphorylation site [posttranslational modification] 862719006069 intermolecular recognition site; other site 862719006070 dimerization interface [polypeptide binding]; other site 862719006071 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 862719006072 putative CheA interaction surface; other site 862719006073 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719006074 putative binding surface; other site 862719006075 active site 862719006076 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 862719006077 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 862719006078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006079 ATP binding site [chemical binding]; other site 862719006080 Mg2+ binding site [ion binding]; other site 862719006081 G-X-G motif; other site 862719006082 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 862719006083 CheW-like domain; Region: CheW; pfam01584 862719006084 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719006085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006086 active site 862719006087 phosphorylation site [posttranslational modification] 862719006088 intermolecular recognition site; other site 862719006089 dimerization interface [polypeptide binding]; other site 862719006090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 862719006091 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 862719006092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719006093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719006094 dimer interface [polypeptide binding]; other site 862719006095 phosphorylation site [posttranslational modification] 862719006096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006097 ATP binding site [chemical binding]; other site 862719006098 Mg2+ binding site [ion binding]; other site 862719006099 G-X-G motif; other site 862719006100 EamA-like transporter family; Region: EamA; pfam00892 862719006101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 862719006102 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 862719006103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719006104 Histidine kinase; Region: HisKA_2; pfam07568 862719006105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006106 ATP binding site [chemical binding]; other site 862719006107 Mg2+ binding site [ion binding]; other site 862719006108 G-X-G motif; other site 862719006109 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 862719006110 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 862719006111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719006112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719006113 DNA binding residues [nucleotide binding] 862719006114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006115 TPR repeat; Region: TPR_11; pfam13414 862719006116 TPR motif; other site 862719006117 binding surface 862719006118 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719006119 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 862719006120 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 862719006121 putative substrate binding pocket [chemical binding]; other site 862719006122 AC domain interface; other site 862719006123 catalytic triad [active] 862719006124 AB domain interface; other site 862719006125 interchain disulfide; other site 862719006126 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719006127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719006128 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 862719006129 dimerization interface [polypeptide binding]; other site 862719006130 substrate binding pocket [chemical binding]; other site 862719006131 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 862719006132 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719006133 putative metal binding site [ion binding]; other site 862719006134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719006135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006136 active site 862719006137 phosphorylation site [posttranslational modification] 862719006138 intermolecular recognition site; other site 862719006139 dimerization interface [polypeptide binding]; other site 862719006140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719006141 DNA binding residues [nucleotide binding] 862719006142 dimerization interface [polypeptide binding]; other site 862719006143 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 862719006144 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862719006145 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719006146 protein binding site [polypeptide binding]; other site 862719006147 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719006148 protein binding site [polypeptide binding]; other site 862719006149 HflC protein; Region: hflC; TIGR01932 862719006150 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 862719006151 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 862719006152 HflK protein; Region: hflK; TIGR01933 862719006153 Domain of unknown function DUF59; Region: DUF59; pfam01883 862719006154 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 862719006155 putative chaperone; Provisional; Region: PRK11678 862719006156 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 862719006157 nucleotide binding site [chemical binding]; other site 862719006158 putative NEF/HSP70 interaction site [polypeptide binding]; other site 862719006159 SBD interface [polypeptide binding]; other site 862719006160 short chain dehydrogenase; Provisional; Region: PRK06139 862719006161 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 862719006162 putative NAD(P) binding site [chemical binding]; other site 862719006163 active site 862719006164 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 862719006165 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 862719006166 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 862719006167 Domain of unknown function (DUF364); Region: DUF364; pfam04016 862719006168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 862719006169 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 862719006170 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 862719006171 C-terminal domain interface [polypeptide binding]; other site 862719006172 GSH binding site (G-site) [chemical binding]; other site 862719006173 dimer interface [polypeptide binding]; other site 862719006174 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 862719006175 dimer interface [polypeptide binding]; other site 862719006176 N-terminal domain interface [polypeptide binding]; other site 862719006177 putative substrate binding pocket (H-site) [chemical binding]; other site 862719006178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719006179 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719006180 substrate binding pocket [chemical binding]; other site 862719006181 membrane-bound complex binding site; other site 862719006182 hinge residues; other site 862719006183 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719006184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719006185 putative active site [active] 862719006186 heme pocket [chemical binding]; other site 862719006187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719006188 dimer interface [polypeptide binding]; other site 862719006189 phosphorylation site [posttranslational modification] 862719006190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006191 ATP binding site [chemical binding]; other site 862719006192 Mg2+ binding site [ion binding]; other site 862719006193 G-X-G motif; other site 862719006194 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006196 active site 862719006197 phosphorylation site [posttranslational modification] 862719006198 intermolecular recognition site; other site 862719006199 dimerization interface [polypeptide binding]; other site 862719006200 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006202 active site 862719006203 phosphorylation site [posttranslational modification] 862719006204 intermolecular recognition site; other site 862719006205 dimerization interface [polypeptide binding]; other site 862719006206 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719006207 putative binding surface; other site 862719006208 active site 862719006209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006210 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006211 active site 862719006212 phosphorylation site [posttranslational modification] 862719006213 intermolecular recognition site; other site 862719006214 dimerization interface [polypeptide binding]; other site 862719006215 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 862719006216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 862719006217 PAS domain; Region: PAS; smart00091 862719006218 PAS fold; Region: PAS_4; pfam08448 862719006219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719006220 putative active site [active] 862719006221 heme pocket [chemical binding]; other site 862719006222 PAS domain S-box; Region: sensory_box; TIGR00229 862719006223 PAS domain; Region: PAS_8; pfam13188 862719006224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719006225 putative active site [active] 862719006226 heme pocket [chemical binding]; other site 862719006227 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719006228 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719006229 metal binding site [ion binding]; metal-binding site 862719006230 active site 862719006231 I-site; other site 862719006232 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 862719006233 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719006234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719006235 catalytic residue [active] 862719006236 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 862719006237 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 862719006238 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 862719006239 PAS domain S-box; Region: sensory_box; TIGR00229 862719006240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719006241 putative active site [active] 862719006242 heme pocket [chemical binding]; other site 862719006243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719006244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719006245 dimer interface [polypeptide binding]; other site 862719006246 phosphorylation site [posttranslational modification] 862719006247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006248 ATP binding site [chemical binding]; other site 862719006249 Mg2+ binding site [ion binding]; other site 862719006250 G-X-G motif; other site 862719006251 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719006252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006253 active site 862719006254 phosphorylation site [posttranslational modification] 862719006255 intermolecular recognition site; other site 862719006256 dimerization interface [polypeptide binding]; other site 862719006257 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 862719006258 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 862719006259 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 862719006260 active site 862719006261 threonine dehydratase; Provisional; Region: PRK07334 862719006262 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 862719006263 tetramer interface [polypeptide binding]; other site 862719006264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719006265 catalytic residue [active] 862719006266 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 862719006267 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719006268 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 862719006269 Walker A/P-loop; other site 862719006270 ATP binding site [chemical binding]; other site 862719006271 Q-loop/lid; other site 862719006272 ABC transporter signature motif; other site 862719006273 Walker B; other site 862719006274 D-loop; other site 862719006275 H-loop/switch region; other site 862719006276 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719006277 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 862719006278 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719006279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719006280 dimer interface [polypeptide binding]; other site 862719006281 conserved gate region; other site 862719006282 putative PBP binding loops; other site 862719006283 ABC-ATPase subunit interface; other site 862719006284 NMT1/THI5 like; Region: NMT1; pfam09084 862719006285 Transcriptional regulators [Transcription]; Region: FadR; COG2186 862719006286 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719006287 DNA-binding site [nucleotide binding]; DNA binding site 862719006288 FCD domain; Region: FCD; pfam07729 862719006289 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 862719006290 active site 862719006291 dimer interfaces [polypeptide binding]; other site 862719006292 catalytic residues [active] 862719006293 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 862719006294 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 862719006295 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 862719006296 NADP binding site [chemical binding]; other site 862719006297 homodimer interface [polypeptide binding]; other site 862719006298 active site 862719006299 Cupin domain; Region: Cupin_2; pfam07883 862719006300 Predicted transcriptional regulators [Transcription]; Region: COG1733 862719006301 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 862719006302 glutathionine S-transferase; Provisional; Region: PRK10542 862719006303 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 862719006304 C-terminal domain interface [polypeptide binding]; other site 862719006305 GSH binding site (G-site) [chemical binding]; other site 862719006306 dimer interface [polypeptide binding]; other site 862719006307 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 862719006308 dimer interface [polypeptide binding]; other site 862719006309 N-terminal domain interface [polypeptide binding]; other site 862719006310 substrate binding pocket (H-site) [chemical binding]; other site 862719006311 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 862719006312 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 862719006313 active site 1 [active] 862719006314 dimer interface [polypeptide binding]; other site 862719006315 hexamer interface [polypeptide binding]; other site 862719006316 active site 2 [active] 862719006317 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719006318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719006319 DNA-binding site [nucleotide binding]; DNA binding site 862719006320 FCD domain; Region: FCD; pfam07729 862719006321 glucuronate isomerase; Reviewed; Region: PRK02925 862719006322 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 862719006323 galactarate dehydratase; Region: galactar-dH20; TIGR03248 862719006324 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 862719006325 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 862719006326 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 862719006327 EamA-like transporter family; Region: EamA; pfam00892 862719006328 EamA-like transporter family; Region: EamA; pfam00892 862719006329 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 862719006330 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 862719006331 substrate binding site [chemical binding]; other site 862719006332 ATP binding site [chemical binding]; other site 862719006333 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 862719006334 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 862719006335 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 862719006336 DNA binding site [nucleotide binding] 862719006337 active site 862719006338 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 862719006339 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862719006340 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862719006341 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719006342 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 862719006343 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 862719006344 homodimer interface [polypeptide binding]; other site 862719006345 active site 862719006346 FMN binding site [chemical binding]; other site 862719006347 substrate binding site [chemical binding]; other site 862719006348 4Fe-4S binding domain; Region: Fer4_6; pfam12837 862719006349 allantoate amidohydrolase; Reviewed; Region: PRK12893 862719006350 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 862719006351 active site 862719006352 metal binding site [ion binding]; metal-binding site 862719006353 dimer interface [polypeptide binding]; other site 862719006354 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 862719006355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719006356 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 862719006357 phenylhydantoinase; Validated; Region: PRK08323 862719006358 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 862719006359 tetramer interface [polypeptide binding]; other site 862719006360 active site 862719006361 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719006362 putative binding surface; other site 862719006363 active site 862719006364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006365 ATP binding site [chemical binding]; other site 862719006366 Mg2+ binding site [ion binding]; other site 862719006367 G-X-G motif; other site 862719006368 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 862719006369 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006371 active site 862719006372 phosphorylation site [posttranslational modification] 862719006373 intermolecular recognition site; other site 862719006374 dimerization interface [polypeptide binding]; other site 862719006375 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 862719006376 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 862719006377 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 862719006378 HEAT repeats; Region: HEAT_2; pfam13646 862719006379 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 862719006380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006381 active site 862719006382 phosphorylation site [posttranslational modification] 862719006383 intermolecular recognition site; other site 862719006384 dimerization interface [polypeptide binding]; other site 862719006385 CheB methylesterase; Region: CheB_methylest; pfam01339 862719006386 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 862719006387 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 862719006388 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 862719006389 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719006390 dimer interface [polypeptide binding]; other site 862719006391 putative CheW interface [polypeptide binding]; other site 862719006392 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719006393 dimer interface [polypeptide binding]; other site 862719006394 putative CheW interface [polypeptide binding]; other site 862719006395 CheC-like family; Region: CheC; pfam04509 862719006396 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719006397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006398 active site 862719006399 phosphorylation site [posttranslational modification] 862719006400 intermolecular recognition site; other site 862719006401 dimerization interface [polypeptide binding]; other site 862719006402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006403 TPR repeat; Region: TPR_11; pfam13414 862719006404 TPR motif; other site 862719006405 binding surface 862719006406 TPR repeat; Region: TPR_11; pfam13414 862719006407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006408 binding surface 862719006409 TPR motif; other site 862719006410 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719006411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006412 binding surface 862719006413 TPR motif; other site 862719006414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006415 binding surface 862719006416 TPR motif; other site 862719006417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006418 binding surface 862719006419 TPR motif; other site 862719006420 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 862719006421 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 862719006422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719006423 dimer interface [polypeptide binding]; other site 862719006424 conserved gate region; other site 862719006425 ABC-ATPase subunit interface; other site 862719006426 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 862719006427 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 862719006428 Walker A/P-loop; other site 862719006429 ATP binding site [chemical binding]; other site 862719006430 Q-loop/lid; other site 862719006431 ABC transporter signature motif; other site 862719006432 Walker B; other site 862719006433 D-loop; other site 862719006434 H-loop/switch region; other site 862719006435 NIL domain; Region: NIL; pfam09383 862719006436 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 862719006437 active site 862719006438 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 862719006439 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 862719006440 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 862719006441 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 862719006442 NAD binding site [chemical binding]; other site 862719006443 dimerization interface [polypeptide binding]; other site 862719006444 product binding site; other site 862719006445 substrate binding site [chemical binding]; other site 862719006446 zinc binding site [ion binding]; other site 862719006447 catalytic residues [active] 862719006448 hypothetical protein; Provisional; Region: PRK02853 862719006449 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 862719006450 Low molecular weight phosphatase family; Region: LMWPc; cd00115 862719006451 active site 862719006452 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 862719006453 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 862719006454 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 862719006455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719006456 HAMP domain; Region: HAMP; pfam00672 862719006457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719006458 dimer interface [polypeptide binding]; other site 862719006459 phosphorylation site [posttranslational modification] 862719006460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719006461 ATP binding site [chemical binding]; other site 862719006462 Mg2+ binding site [ion binding]; other site 862719006463 G-X-G motif; other site 862719006464 Response regulator receiver domain; Region: Response_reg; pfam00072 862719006465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006466 active site 862719006467 phosphorylation site [posttranslational modification] 862719006468 intermolecular recognition site; other site 862719006469 dimerization interface [polypeptide binding]; other site 862719006470 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862719006471 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719006472 catalytic residue [active] 862719006473 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 862719006474 rRNA binding site [nucleotide binding]; other site 862719006475 predicted 30S ribosome binding site; other site 862719006476 Maf-like protein; Region: Maf; pfam02545 862719006477 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 862719006478 active site 862719006479 dimer interface [polypeptide binding]; other site 862719006480 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 862719006481 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 862719006482 homodimer interface [polypeptide binding]; other site 862719006483 oligonucleotide binding site [chemical binding]; other site 862719006484 Domain of unknown function (DUF329); Region: DUF329; pfam03884 862719006485 LabA_like proteins; Region: LabA_like/DUF88; cl10034 862719006486 putative metal binding site [ion binding]; other site 862719006487 Winged helix-turn helix; Region: HTH_29; pfam13551 862719006488 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719006489 Winged helix-turn helix; Region: HTH_33; pfam13592 862719006490 DDE superfamily endonuclease; Region: DDE_3; pfam13358 862719006491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 862719006492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 862719006493 Transposase; Region: DDE_Tnp_ISL3; pfam01610 862719006494 Transposase; Region: DDE_Tnp_ISL3; pfam01610 862719006495 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719006496 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 862719006497 Protein kinase domain; Region: Pkinase; pfam00069 862719006498 Catalytic domain of Protein Kinases; Region: PKc; cd00180 862719006499 active site 862719006500 ATP binding site [chemical binding]; other site 862719006501 substrate binding site [chemical binding]; other site 862719006502 activation loop (A-loop); other site 862719006503 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862719006504 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862719006505 phosphopeptide binding site; other site 862719006506 Protein kinase domain; Region: Pkinase; pfam00069 862719006507 Catalytic domain of Protein Kinases; Region: PKc; cd00180 862719006508 active site 862719006509 ATP binding site [chemical binding]; other site 862719006510 substrate binding site [chemical binding]; other site 862719006511 activation loop (A-loop); other site 862719006512 Protein of unknown function (DUF805); Region: DUF805; pfam05656 862719006513 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 862719006514 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862719006515 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862719006516 phosphopeptide binding site; other site 862719006517 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862719006518 Protein phosphatase 2C; Region: PP2C; pfam00481 862719006519 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 862719006520 active site 862719006521 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 862719006522 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862719006523 phosphopeptide binding site; other site 862719006524 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 862719006525 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862719006526 phosphopeptide binding site; other site 862719006527 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 862719006528 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719006529 ligand binding site [chemical binding]; other site 862719006530 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 862719006531 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 862719006532 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 862719006533 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719006534 active site 862719006535 Int/Topo IB signature motif; other site 862719006536 DNA binding site [nucleotide binding] 862719006537 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 862719006538 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 862719006539 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 862719006540 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 862719006541 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 862719006542 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862719006543 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 862719006544 NADH dehydrogenase; Region: NADHdh; cl00469 862719006545 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 862719006546 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719006547 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 862719006548 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 862719006549 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719006550 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 862719006551 MoaE interaction surface [polypeptide binding]; other site 862719006552 MoeB interaction surface [polypeptide binding]; other site 862719006553 thiocarboxylated glycine; other site 862719006554 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 862719006555 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 862719006556 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 862719006557 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : putative carrier 862719006558 GAF domain; Region: GAF; pfam01590 862719006559 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719006560 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719006561 ligand binding site [chemical binding]; other site 862719006562 flexible hinge region; other site 862719006563 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 862719006564 putative switch regulator; other site 862719006565 non-specific DNA interactions [nucleotide binding]; other site 862719006566 DNA binding site [nucleotide binding] 862719006567 sequence specific DNA binding site [nucleotide binding]; other site 862719006568 putative cAMP binding site [chemical binding]; other site 862719006569 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719006570 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 862719006571 AsnC family; Region: AsnC_trans_reg; pfam01037 862719006572 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 862719006573 homotrimer interaction site [polypeptide binding]; other site 862719006574 putative active site [active] 862719006575 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 862719006576 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 862719006577 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719006578 catalytic residue [active] 862719006579 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 862719006580 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 862719006581 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862719006582 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719006583 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719006584 TM-ABC transporter signature motif; other site 862719006585 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719006586 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719006587 TM-ABC transporter signature motif; other site 862719006588 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719006589 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719006590 Walker A/P-loop; other site 862719006591 ATP binding site [chemical binding]; other site 862719006592 Q-loop/lid; other site 862719006593 ABC transporter signature motif; other site 862719006594 Walker B; other site 862719006595 D-loop; other site 862719006596 H-loop/switch region; other site 862719006597 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719006598 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719006599 Walker A/P-loop; other site 862719006600 ATP binding site [chemical binding]; other site 862719006601 Q-loop/lid; other site 862719006602 ABC transporter signature motif; other site 862719006603 Walker B; other site 862719006604 D-loop; other site 862719006605 H-loop/switch region; other site 862719006606 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 862719006607 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 862719006608 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 862719006609 metal binding site [ion binding]; metal-binding site 862719006610 putative dimer interface [polypeptide binding]; other site 862719006611 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 862719006612 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719006613 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 862719006614 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 862719006615 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 862719006616 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719006617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719006618 Walker A/P-loop; other site 862719006619 ATP binding site [chemical binding]; other site 862719006620 Q-loop/lid; other site 862719006621 ABC transporter signature motif; other site 862719006622 Walker B; other site 862719006623 D-loop; other site 862719006624 H-loop/switch region; other site 862719006625 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719006626 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719006627 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719006628 VCBS repeat; Region: VCBS_repeat; TIGR01965 862719006629 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 862719006630 Ca2+ binding site [ion binding]; other site 862719006631 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719006632 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 862719006633 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 862719006634 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719006635 Family description; Region: VCBS; pfam13517 862719006636 Family description; Region: VCBS; pfam13517 862719006637 Family description; Region: VCBS; pfam13517 862719006638 Family description; Region: VCBS; pfam13517 862719006639 serine acetyltransferase; Provisional; Region: cysE; PRK11132 862719006640 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 862719006641 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 862719006642 trimer interface [polypeptide binding]; other site 862719006643 active site 862719006644 substrate binding site [chemical binding]; other site 862719006645 CoA binding site [chemical binding]; other site 862719006646 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 862719006647 Cupin domain; Region: Cupin_2; cl17218 862719006648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719006649 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 862719006650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862719006651 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 862719006652 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719006653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719006654 dimerization interface [polypeptide binding]; other site 862719006655 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719006656 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719006657 dimer interface [polypeptide binding]; other site 862719006658 putative CheW interface [polypeptide binding]; other site 862719006659 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 862719006660 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 862719006661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719006662 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862719006663 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 862719006664 Walker A/P-loop; other site 862719006665 ATP binding site [chemical binding]; other site 862719006666 Q-loop/lid; other site 862719006667 ABC transporter signature motif; other site 862719006668 Walker B; other site 862719006669 D-loop; other site 862719006670 H-loop/switch region; other site 862719006671 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719006672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719006673 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 862719006674 NMT1-like family; Region: NMT1_2; pfam13379 862719006675 Uncharacterized conserved protein [Function unknown]; Region: COG5470 862719006676 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 862719006677 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 862719006678 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 862719006679 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 862719006680 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 862719006681 homodimer interface [polypeptide binding]; other site 862719006682 ligand binding site [chemical binding]; other site 862719006683 NAD(P) binding site [chemical binding]; other site 862719006684 trimer interface B [polypeptide binding]; other site 862719006685 trimer interface A [polypeptide binding]; other site 862719006686 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 862719006687 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 862719006688 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 862719006689 Walker A/P-loop; other site 862719006690 ATP binding site [chemical binding]; other site 862719006691 Q-loop/lid; other site 862719006692 ABC transporter signature motif; other site 862719006693 Walker B; other site 862719006694 D-loop; other site 862719006695 H-loop/switch region; other site 862719006696 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 862719006697 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 862719006698 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 862719006699 ligand binding site [chemical binding]; other site 862719006700 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 862719006701 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 862719006702 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 862719006703 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 862719006704 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 862719006705 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 862719006706 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 862719006707 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 862719006708 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 862719006709 Nitrogen regulatory protein P-II; Region: P-II; smart00938 862719006710 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 862719006711 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 862719006712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719006713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719006714 homodimer interface [polypeptide binding]; other site 862719006715 catalytic residue [active] 862719006716 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 862719006717 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 862719006718 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 862719006719 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 862719006720 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 862719006721 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 862719006722 putative PBP binding regions; other site 862719006723 ABC-ATPase subunit interface; other site 862719006724 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 862719006725 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 862719006726 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 862719006727 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 862719006728 metal binding site [ion binding]; metal-binding site 862719006729 dihydrodipicolinate reductase; Provisional; Region: PRK00048 862719006730 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 862719006731 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 862719006732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719006733 active site 862719006734 phosphorylation site [posttranslational modification] 862719006735 intermolecular recognition site; other site 862719006736 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719006737 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719006738 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719006739 Zn2+ binding site [ion binding]; other site 862719006740 Mg2+ binding site [ion binding]; other site 862719006741 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 862719006742 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 862719006743 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 862719006744 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 862719006745 FAD binding pocket [chemical binding]; other site 862719006746 FAD binding motif [chemical binding]; other site 862719006747 phosphate binding motif [ion binding]; other site 862719006748 beta-alpha-beta structure motif; other site 862719006749 NAD binding pocket [chemical binding]; other site 862719006750 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719006751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719006752 non-specific DNA binding site [nucleotide binding]; other site 862719006753 salt bridge; other site 862719006754 sequence-specific DNA binding site [nucleotide binding]; other site 862719006755 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 862719006756 Domain of unknown function (DUF955); Region: DUF955; pfam06114 862719006757 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 862719006758 isocitrate lyase; Provisional; Region: PRK15063 862719006759 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 862719006760 tetramer interface [polypeptide binding]; other site 862719006761 active site 862719006762 Mg2+/Mn2+ binding site [ion binding]; other site 862719006763 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 862719006764 intracellular protease, PfpI family; Region: PfpI; TIGR01382 862719006765 conserved cys residue [active] 862719006766 HAMP domain; Region: HAMP; pfam00672 862719006767 dimerization interface [polypeptide binding]; other site 862719006768 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719006769 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719006770 dimer interface [polypeptide binding]; other site 862719006771 putative CheW interface [polypeptide binding]; other site 862719006772 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 862719006773 prephenate dehydrogenase; Validated; Region: PRK08507 862719006774 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 862719006775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719006776 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 862719006777 dimerization interface [polypeptide binding]; other site 862719006778 peroxiredoxin; Region: AhpC; TIGR03137 862719006779 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 862719006780 dimer interface [polypeptide binding]; other site 862719006781 decamer (pentamer of dimers) interface [polypeptide binding]; other site 862719006782 catalytic triad [active] 862719006783 peroxidatic and resolving cysteines [active] 862719006784 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 862719006785 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 862719006786 catalytic residue [active] 862719006787 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 862719006788 catalytic residues [active] 862719006789 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862719006790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719006791 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719006792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006793 binding surface 862719006794 TPR motif; other site 862719006795 TPR repeat; Region: TPR_11; pfam13414 862719006796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006797 binding surface 862719006798 TPR motif; other site 862719006799 TPR repeat; Region: TPR_11; pfam13414 862719006800 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 862719006801 GDP-Fucose binding site [chemical binding]; other site 862719006802 hypothetical protein; Provisional; Region: PRK08317 862719006803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719006804 S-adenosylmethionine binding site [chemical binding]; other site 862719006805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719006806 S-adenosylmethionine binding site [chemical binding]; other site 862719006807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006808 TPR motif; other site 862719006809 binding surface 862719006810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006811 binding surface 862719006812 TPR motif; other site 862719006813 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719006814 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719006815 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719006816 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719006817 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 862719006818 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 862719006819 NADP binding site [chemical binding]; other site 862719006820 active site 862719006821 putative substrate binding site [chemical binding]; other site 862719006822 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 862719006823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006824 binding surface 862719006825 TPR motif; other site 862719006826 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719006827 TPR repeat; Region: TPR_11; pfam13414 862719006828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006829 binding surface 862719006830 TPR motif; other site 862719006831 TPR repeat; Region: TPR_11; pfam13414 862719006832 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 862719006833 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 862719006834 putative active site [active] 862719006835 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 862719006836 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719006837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719006838 Walker A/P-loop; other site 862719006839 ATP binding site [chemical binding]; other site 862719006840 Q-loop/lid; other site 862719006841 ABC transporter signature motif; other site 862719006842 Walker B; other site 862719006843 D-loop; other site 862719006844 H-loop/switch region; other site 862719006845 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719006846 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862719006847 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719006848 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 862719006849 Sel1-like repeats; Region: SEL1; smart00671 862719006850 Sel1-like repeats; Region: SEL1; smart00671 862719006851 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 862719006852 Sel1-like repeats; Region: SEL1; smart00671 862719006853 Sel1-like repeats; Region: SEL1; smart00671 862719006854 Sel1-like repeats; Region: SEL1; smart00671 862719006855 Sel1-like repeats; Region: SEL1; smart00671 862719006856 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 862719006857 ADP-ribose binding site [chemical binding]; other site 862719006858 dimer interface [polypeptide binding]; other site 862719006859 active site 862719006860 nudix motif; other site 862719006861 metal binding site [ion binding]; metal-binding site 862719006862 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 862719006863 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 862719006864 B12 binding domain; Region: B12-binding; pfam02310 862719006865 B12 binding site [chemical binding]; other site 862719006866 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 862719006867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719006868 FeS/SAM binding site; other site 862719006869 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 862719006870 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 862719006871 NADP binding site [chemical binding]; other site 862719006872 active site 862719006873 putative substrate binding site [chemical binding]; other site 862719006874 Autophagy protein 16 (ATG16); Region: ATG16; pfam08614 862719006875 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 862719006876 active site 862719006877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719006878 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 862719006879 hypothetical protein; Provisional; Region: PRK05849 862719006880 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 862719006881 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 862719006882 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 862719006883 catalytic triad [active] 862719006884 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 862719006885 active site 862719006886 metal-binding site 862719006887 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 862719006888 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 862719006889 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 862719006890 C1q domain; Region: C1q; cl17543 862719006891 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 862719006892 catalytic core [active] 862719006893 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 862719006894 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 862719006895 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 862719006896 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 862719006897 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 862719006898 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862719006899 inhibitor-cofactor binding pocket; inhibition site 862719006900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719006901 catalytic residue [active] 862719006902 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 862719006903 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 862719006904 alpha subunit interface [polypeptide binding]; other site 862719006905 TPP binding site [chemical binding]; other site 862719006906 heterodimer interface [polypeptide binding]; other site 862719006907 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719006908 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 862719006909 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 862719006910 tetramer interface [polypeptide binding]; other site 862719006911 TPP-binding site [chemical binding]; other site 862719006912 heterodimer interface [polypeptide binding]; other site 862719006913 phosphorylation loop region [posttranslational modification] 862719006914 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719006915 extended (e) SDRs; Region: SDR_e; cd08946 862719006916 NAD(P) binding site [chemical binding]; other site 862719006917 active site 862719006918 substrate binding site [chemical binding]; other site 862719006919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719006920 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 862719006921 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 862719006922 Substrate binding site; other site 862719006923 Mg++ binding site; other site 862719006924 metal-binding site 862719006925 Mg++ binding site; other site 862719006926 metal-binding site 862719006927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719006928 active site 862719006929 motif I; other site 862719006930 motif II; other site 862719006931 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719006932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006933 binding surface 862719006934 TPR motif; other site 862719006935 TPR repeat; Region: TPR_11; pfam13414 862719006936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006937 binding surface 862719006938 TPR motif; other site 862719006939 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719006940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006941 binding surface 862719006942 TPR motif; other site 862719006943 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719006944 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719006945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006946 binding surface 862719006947 TPR motif; other site 862719006948 TPR repeat; Region: TPR_11; pfam13414 862719006949 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862719006950 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719006951 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719006952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719006953 S-adenosylmethionine binding site [chemical binding]; other site 862719006954 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 862719006955 active site 862719006956 catalytic site [active] 862719006957 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 862719006958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719006959 motif II; other site 862719006960 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 862719006961 Ligand binding site; other site 862719006962 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 862719006963 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 862719006964 Ligand binding site; other site 862719006965 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719006966 active site 862719006967 WavE lipopolysaccharide synthesis; Region: WavE; pfam07507 862719006968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006969 binding surface 862719006970 TPR repeat; Region: TPR_11; pfam13414 862719006971 TPR motif; other site 862719006972 TPR repeat; Region: TPR_11; pfam13414 862719006973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006974 binding surface 862719006975 TPR motif; other site 862719006976 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719006977 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 862719006978 dimer interface [polypeptide binding]; other site 862719006979 active site 862719006980 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719006981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006982 binding surface 862719006983 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719006984 TPR motif; other site 862719006985 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719006986 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 862719006987 GDP-Fucose binding site [chemical binding]; other site 862719006988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719006989 TPR motif; other site 862719006990 TPR repeat; Region: TPR_11; pfam13414 862719006991 binding surface 862719006992 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719006993 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719006994 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 862719006995 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719006996 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719006997 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 862719006998 active site 862719006999 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 862719007000 active site 862719007001 putative substrate binding region [chemical binding]; other site 862719007002 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719007003 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719007004 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 862719007005 PemK-like protein; Region: PemK; pfam02452 862719007006 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719007007 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719007008 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719007009 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719007010 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 862719007011 Sporulation related domain; Region: SPOR; pfam05036 862719007012 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 862719007013 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 862719007014 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 862719007015 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 862719007016 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 862719007017 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 862719007018 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719007019 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 862719007020 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 862719007021 Phage Tail Collar Domain; Region: Collar; pfam07484 862719007022 Evidence 2b : Function of strongly homologous gene 862719007023 TPR repeat; Region: TPR_11; pfam13414 862719007024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007025 binding surface 862719007026 TPR motif; other site 862719007027 Tetratricopeptide repeat; Region: TPR_9; pfam13371 862719007028 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719007029 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 862719007030 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 862719007031 ligand binding site; other site 862719007032 tetramer interface; other site 862719007033 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719007034 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 862719007035 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719007036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719007037 NAD(P) binding site [chemical binding]; other site 862719007038 active site 862719007039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719007040 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 862719007041 NAD(P) binding site [chemical binding]; other site 862719007042 active site 862719007043 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 862719007044 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 862719007045 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 862719007046 B12 binding site [chemical binding]; other site 862719007047 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 862719007048 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719007049 FeS/SAM binding site; other site 862719007050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719007051 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 862719007052 NAD(P) binding site [chemical binding]; other site 862719007053 active site 862719007054 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 862719007055 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 862719007056 active site 862719007057 homodimer interface [polypeptide binding]; other site 862719007058 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 862719007059 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862719007060 inhibitor-cofactor binding pocket; inhibition site 862719007061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719007062 catalytic residue [active] 862719007063 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719007064 active site 862719007065 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719007066 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 862719007067 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719007068 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 862719007069 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 862719007070 active site 862719007071 cosubstrate binding site; other site 862719007072 catalytic site [active] 862719007073 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 862719007074 NeuB family; Region: NeuB; pfam03102 862719007075 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 862719007076 NeuB binding interface [polypeptide binding]; other site 862719007077 putative substrate binding site [chemical binding]; other site 862719007078 Cephalosporin hydroxylase; Region: CmcI; pfam04989 862719007079 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 862719007080 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 862719007081 dimer interface [polypeptide binding]; other site 862719007082 active site 862719007083 CoA binding pocket [chemical binding]; other site 862719007084 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719007085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719007086 sequence-specific DNA binding site [nucleotide binding]; other site 862719007087 salt bridge; other site 862719007088 potential frameshift: common BLAST hit: gi|288963057|ref|YP_003453336.1| hipA domain protein 862719007089 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 862719007090 HipA N-terminal domain; Region: Couple_hipA; cl11853 862719007091 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719007092 classical (c) SDRs; Region: SDR_c; cd05233 862719007093 NAD(P) binding site [chemical binding]; other site 862719007094 active site 862719007095 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 862719007096 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 862719007097 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 862719007098 oligomeric interface; other site 862719007099 putative active site [active] 862719007100 homodimer interface [polypeptide binding]; other site 862719007101 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 862719007102 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 862719007103 [2Fe-2S] cluster binding site [ion binding]; other site 862719007104 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 862719007105 alpha subunit interface [polypeptide binding]; other site 862719007106 active site 862719007107 substrate binding site [chemical binding]; other site 862719007108 Fe binding site [ion binding]; other site 862719007109 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 862719007110 Asp-box motif; other site 862719007111 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719007112 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719007113 active site 862719007114 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 862719007115 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 862719007116 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719007117 active site 862719007118 Anp1; Region: Anp1; pfam03452 862719007119 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 862719007120 dimer interface [polypeptide binding]; other site 862719007121 ADP-ribose binding site [chemical binding]; other site 862719007122 active site 862719007123 nudix motif; other site 862719007124 metal binding site [ion binding]; metal-binding site 862719007125 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 862719007126 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 862719007127 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 862719007128 catalytic residues [active] 862719007129 catalytic nucleophile [active] 862719007130 Recombinase; Region: Recombinase; pfam07508 862719007131 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 862719007132 Helix-turn-helix domain; Region: HTH_17; pfam12728 862719007133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 862719007134 Transposase; Region: HTH_Tnp_1; pfam01527 862719007135 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719007136 FOG: CBS domain [General function prediction only]; Region: COG0517 862719007137 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 862719007138 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 862719007139 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 862719007140 Substrate binding site; other site 862719007141 metal-binding site 862719007142 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 862719007143 Ligand Binding Site [chemical binding]; other site 862719007144 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 862719007145 Methyltransferase domain; Region: Methyltransf_24; pfam13578 862719007146 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719007147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007148 S-adenosylmethionine binding site [chemical binding]; other site 862719007149 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719007150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 862719007151 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 862719007152 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 862719007153 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 862719007154 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 862719007155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 862719007156 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 862719007157 Transposase; Region: HTH_Tnp_1; pfam01527 862719007158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 862719007159 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862719007160 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 862719007161 Cephalosporin hydroxylase; Region: CmcI; pfam04989 862719007162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719007163 NAD(P) binding site [chemical binding]; other site 862719007164 active site 862719007165 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 862719007166 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 862719007167 substrate binding site; other site 862719007168 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 862719007169 ligand binding site; other site 862719007170 tetramer interface; other site 862719007171 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 862719007172 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 862719007173 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 862719007174 putative active site [active] 862719007175 oxyanion strand; other site 862719007176 catalytic triad [active] 862719007177 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 862719007178 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 862719007179 substrate binding site [chemical binding]; other site 862719007180 glutamase interaction surface [polypeptide binding]; other site 862719007181 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 862719007182 extended (e) SDRs; Region: SDR_e; cd08946 862719007183 NAD(P) binding site [chemical binding]; other site 862719007184 active site 862719007185 substrate binding site [chemical binding]; other site 862719007186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007187 S-adenosylmethionine binding site [chemical binding]; other site 862719007188 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719007189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 862719007190 Transposase; Region: DDE_Tnp_ISL3; pfam01610 862719007191 Transposase; Region: DDE_Tnp_ISL3; pfam01610 862719007192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007193 TPR motif; other site 862719007194 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719007195 binding surface 862719007196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007197 binding surface 862719007198 TPR motif; other site 862719007199 TPR repeat; Region: TPR_11; pfam13414 862719007200 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719007201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007202 S-adenosylmethionine binding site [chemical binding]; other site 862719007203 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 862719007204 Ligand binding site; other site 862719007205 Putative Catalytic site; other site 862719007206 DXD motif; other site 862719007207 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 862719007208 Right handed beta helix region; Region: Beta_helix; pfam13229 862719007209 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 862719007210 Peptidase family M23; Region: Peptidase_M23; pfam01551 862719007211 AMIN domain; Region: AMIN; pfam11741 862719007212 Uncharacterized conserved protein [Function unknown]; Region: COG1739 862719007213 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 862719007214 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 862719007215 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719007216 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 862719007217 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 862719007218 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862719007219 inhibitor-cofactor binding pocket; inhibition site 862719007220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719007221 catalytic residue [active] 862719007222 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 862719007223 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 862719007224 NAD(P) binding site [chemical binding]; other site 862719007225 homodimer interface [polypeptide binding]; other site 862719007226 substrate binding site [chemical binding]; other site 862719007227 active site 862719007228 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719007229 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 862719007230 putative ADP-binding pocket [chemical binding]; other site 862719007231 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 862719007232 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 862719007233 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 862719007234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 862719007235 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 862719007236 Probable transposase; Region: OrfB_IS605; pfam01385 862719007237 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 862719007238 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 862719007239 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 862719007240 Substrate binding site; other site 862719007241 Cupin domain; Region: Cupin_2; cl17218 862719007242 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 862719007243 Protein of unknown function (DUF497); Region: DUF497; pfam04365 862719007244 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 862719007245 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 862719007246 putative active site [active] 862719007247 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719007248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719007249 Walker A/P-loop; other site 862719007250 ATP binding site [chemical binding]; other site 862719007251 Q-loop/lid; other site 862719007252 ABC transporter signature motif; other site 862719007253 Walker B; other site 862719007254 D-loop; other site 862719007255 H-loop/switch region; other site 862719007256 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719007257 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719007258 Predicted membrane protein [Function unknown]; Region: COG2246 862719007259 GtrA-like protein; Region: GtrA; pfam04138 862719007260 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719007261 active site 862719007262 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719007263 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 862719007264 NAD binding site [chemical binding]; other site 862719007265 putative substrate binding site 2 [chemical binding]; other site 862719007266 putative substrate binding site 1 [chemical binding]; other site 862719007267 active site 862719007268 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 862719007269 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 862719007270 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 862719007271 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 862719007272 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 862719007273 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 862719007274 NAD binding site [chemical binding]; other site 862719007275 homodimer interface [polypeptide binding]; other site 862719007276 active site 862719007277 substrate binding site [chemical binding]; other site 862719007278 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 862719007279 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 862719007280 substrate binding site; other site 862719007281 tetramer interface; other site 862719007282 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 862719007283 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 862719007284 NADP binding site [chemical binding]; other site 862719007285 active site 862719007286 putative substrate binding site [chemical binding]; other site 862719007287 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 862719007288 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 862719007289 NAD binding site [chemical binding]; other site 862719007290 substrate binding site [chemical binding]; other site 862719007291 homodimer interface [polypeptide binding]; other site 862719007292 active site 862719007293 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 862719007294 Methyltransferase domain; Region: Methyltransf_24; pfam13578 862719007295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 862719007296 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 862719007297 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 862719007298 Probable Catalytic site; other site 862719007299 metal-binding site 862719007300 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719007301 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 862719007302 Probable Catalytic site; other site 862719007303 metal-binding site 862719007304 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 862719007305 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 862719007306 Walker A/P-loop; other site 862719007307 ATP binding site [chemical binding]; other site 862719007308 Q-loop/lid; other site 862719007309 ABC transporter signature motif; other site 862719007310 Walker B; other site 862719007311 D-loop; other site 862719007312 H-loop/switch region; other site 862719007313 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 862719007314 putative carbohydrate binding site [chemical binding]; other site 862719007315 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 862719007316 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 862719007317 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 862719007318 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 862719007319 Active Sites [active] 862719007320 Evidence 7 : Gene remnant; Product type e : enzyme 862719007321 Evidence 7 : Gene remnant; Product type e : enzyme 862719007322 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719007323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007324 TPR motif; other site 862719007325 binding surface 862719007326 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 862719007327 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 862719007328 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 862719007329 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 862719007330 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 862719007331 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 862719007332 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 862719007333 active site 862719007334 NTP binding site [chemical binding]; other site 862719007335 metal binding triad [ion binding]; metal-binding site 862719007336 antibiotic binding site [chemical binding]; other site 862719007337 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 862719007338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719007339 non-specific DNA binding site [nucleotide binding]; other site 862719007340 salt bridge; other site 862719007341 sequence-specific DNA binding site [nucleotide binding]; other site 862719007342 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 862719007343 translation initiation factor IF-3; Region: infC; TIGR00168 862719007344 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 862719007345 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 862719007346 PAS domain S-box; Region: sensory_box; TIGR00229 862719007347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007348 putative active site [active] 862719007349 heme pocket [chemical binding]; other site 862719007350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007351 ATP binding site [chemical binding]; other site 862719007352 Mg2+ binding site [ion binding]; other site 862719007353 G-X-G motif; other site 862719007354 Response regulator receiver domain; Region: Response_reg; pfam00072 862719007355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007356 active site 862719007357 phosphorylation site [posttranslational modification] 862719007358 intermolecular recognition site; other site 862719007359 dimerization interface [polypeptide binding]; other site 862719007360 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 862719007361 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 862719007362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719007363 dimer interface [polypeptide binding]; other site 862719007364 phosphorylation site [posttranslational modification] 862719007365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007366 ATP binding site [chemical binding]; other site 862719007367 Mg2+ binding site [ion binding]; other site 862719007368 G-X-G motif; other site 862719007369 Response regulator receiver domain; Region: Response_reg; pfam00072 862719007370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007371 active site 862719007372 phosphorylation site [posttranslational modification] 862719007373 intermolecular recognition site; other site 862719007374 dimerization interface [polypeptide binding]; other site 862719007375 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 862719007376 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 862719007377 DNA binding residues [nucleotide binding] 862719007378 dimer interface [polypeptide binding]; other site 862719007379 putative metal binding site [ion binding]; other site 862719007380 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862719007381 metal-binding site [ion binding] 862719007382 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 862719007383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862719007384 Soluble P-type ATPase [General function prediction only]; Region: COG4087 862719007385 Predicted metal-binding protein [General function prediction only]; Region: COG3019 862719007386 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 862719007387 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 862719007388 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 862719007389 Substrate binding site; other site 862719007390 Mg++ binding site; other site 862719007391 metal-binding site 862719007392 Mg++ binding site; other site 862719007393 metal-binding site 862719007394 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 862719007395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719007396 motif I; other site 862719007397 motif II; other site 862719007398 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 862719007399 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 862719007400 catalytic residues [active] 862719007401 catalytic nucleophile [active] 862719007402 Presynaptic Site I dimer interface [polypeptide binding]; other site 862719007403 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 862719007404 Synaptic Flat tetramer interface [polypeptide binding]; other site 862719007405 Synaptic Site I dimer interface [polypeptide binding]; other site 862719007406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007407 TPR motif; other site 862719007408 TPR repeat; Region: TPR_11; pfam13414 862719007409 binding surface 862719007410 Tetratricopeptide repeat; Region: TPR_9; pfam13371 862719007411 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719007412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719007413 NB-ARC domain; Region: NB-ARC; pfam00931 862719007414 Walker A motif; other site 862719007415 ATP binding site [chemical binding]; other site 862719007416 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719007417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007418 binding surface 862719007419 TPR motif; other site 862719007420 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719007421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007422 binding surface 862719007423 TPR motif; other site 862719007424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719007425 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719007426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007427 binding surface 862719007428 TPR motif; other site 862719007429 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719007430 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719007431 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719007432 P-loop; other site 862719007433 Magnesium ion binding site [ion binding]; other site 862719007434 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 862719007435 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719007436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007437 TPR motif; other site 862719007438 binding surface 862719007439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007440 TPR repeat; Region: TPR_11; pfam13414 862719007441 binding surface 862719007442 TPR motif; other site 862719007443 TPR repeat; Region: TPR_11; pfam13414 862719007444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007445 binding surface 862719007446 TPR motif; other site 862719007447 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719007448 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 862719007449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719007450 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719007451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007452 S-adenosylmethionine binding site [chemical binding]; other site 862719007453 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719007454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007455 S-adenosylmethionine binding site [chemical binding]; other site 862719007456 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 862719007457 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 862719007458 Ligand binding site; other site 862719007459 Putative Catalytic site; other site 862719007460 DXD motif; other site 862719007461 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 862719007462 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 862719007463 active site 862719007464 dimer interface [polypeptide binding]; other site 862719007465 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 862719007466 Ligand Binding Site [chemical binding]; other site 862719007467 Molecular Tunnel; other site 862719007468 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719007469 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719007470 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 862719007471 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862719007472 inhibitor-cofactor binding pocket; inhibition site 862719007473 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719007474 catalytic residue [active] 862719007475 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719007476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719007477 NAD(P) binding site [chemical binding]; other site 862719007478 active site 862719007479 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 862719007480 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 862719007481 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719007482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007483 S-adenosylmethionine binding site [chemical binding]; other site 862719007484 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719007485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007486 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 862719007487 GDP-Fucose binding site [chemical binding]; other site 862719007488 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 862719007489 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 862719007490 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719007491 active site 862719007492 TPR repeat; Region: TPR_11; pfam13414 862719007493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007494 binding surface 862719007495 TPR motif; other site 862719007496 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719007497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007498 binding surface 862719007499 TPR motif; other site 862719007500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007501 binding surface 862719007502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007503 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719007504 S-adenosylmethionine binding site [chemical binding]; other site 862719007505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007506 TPR motif; other site 862719007507 binding surface 862719007508 TPR repeat; Region: TPR_11; pfam13414 862719007509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007510 binding surface 862719007511 TPR motif; other site 862719007512 TPR repeat; Region: TPR_11; pfam13414 862719007513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007514 binding surface 862719007515 TPR motif; other site 862719007516 TPR repeat; Region: TPR_11; pfam13414 862719007517 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719007518 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 862719007519 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 862719007520 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 862719007521 NADP-binding site; other site 862719007522 homotetramer interface [polypeptide binding]; other site 862719007523 substrate binding site [chemical binding]; other site 862719007524 homodimer interface [polypeptide binding]; other site 862719007525 active site 862719007526 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8793876, 15033235; Product type e : enzyme 862719007527 Evidence 2b : Function of strongly homologous gene; Product type s : structure 862719007528 DnaA N-terminal domain; Region: DnaA_N; pfam11638 862719007529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719007530 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862719007531 Walker A motif; other site 862719007532 ATP binding site [chemical binding]; other site 862719007533 Walker B motif; other site 862719007534 arginine finger; other site 862719007535 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 862719007536 DnaA box-binding interface [nucleotide binding]; other site 862719007537 Response regulator receiver domain; Region: Response_reg; pfam00072 862719007538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007539 active site 862719007540 phosphorylation site [posttranslational modification] 862719007541 intermolecular recognition site; other site 862719007542 dimerization interface [polypeptide binding]; other site 862719007543 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719007544 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719007545 metal binding site [ion binding]; metal-binding site 862719007546 active site 862719007547 I-site; other site 862719007548 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719007549 dimerization interface [polypeptide binding]; other site 862719007550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719007551 dimer interface [polypeptide binding]; other site 862719007552 phosphorylation site [posttranslational modification] 862719007553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007554 ATP binding site [chemical binding]; other site 862719007555 Mg2+ binding site [ion binding]; other site 862719007556 G-X-G motif; other site 862719007557 osmolarity response regulator; Provisional; Region: ompR; PRK09468 862719007558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007559 active site 862719007560 phosphorylation site [posttranslational modification] 862719007561 intermolecular recognition site; other site 862719007562 dimerization interface [polypeptide binding]; other site 862719007563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719007564 DNA binding site [nucleotide binding] 862719007565 LTXXQ motif family protein; Region: LTXXQ; pfam07813 862719007566 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719007567 nucleotide binding region [chemical binding]; other site 862719007568 ATP-binding site [chemical binding]; other site 862719007569 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862719007570 RNA binding surface [nucleotide binding]; other site 862719007571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 862719007572 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719007573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719007574 Walker A/P-loop; other site 862719007575 ATP binding site [chemical binding]; other site 862719007576 Q-loop/lid; other site 862719007577 ABC transporter signature motif; other site 862719007578 Walker B; other site 862719007579 D-loop; other site 862719007580 H-loop/switch region; other site 862719007581 TOBE domain; Region: TOBE_2; pfam08402 862719007582 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 862719007583 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 862719007584 Transglycosylase; Region: Transgly; pfam00912 862719007585 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 862719007586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 862719007587 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 862719007588 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719007589 ligand binding site [chemical binding]; other site 862719007590 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 862719007591 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 862719007592 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 862719007593 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719007594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007595 binding surface 862719007596 TPR motif; other site 862719007597 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719007598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007599 binding surface 862719007600 TPR motif; other site 862719007601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719007602 binding surface 862719007603 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719007604 TPR motif; other site 862719007605 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 862719007606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007607 S-adenosylmethionine binding site [chemical binding]; other site 862719007608 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 862719007609 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 862719007610 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719007611 FeS/SAM binding site; other site 862719007612 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 862719007613 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 862719007614 homotetramer interface [polypeptide binding]; other site 862719007615 ligand binding site [chemical binding]; other site 862719007616 catalytic site [active] 862719007617 NAD binding site [chemical binding]; other site 862719007618 Post-segregation antitoxin CcdA; Region: CcdA; cl02188 862719007619 CcdB protein; Region: CcdB; cl03380 862719007620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862719007621 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 862719007622 Bacterial SH3 domain; Region: SH3_3; pfam08239 862719007623 Bacterial SH3 domain; Region: SH3_3; pfam08239 862719007624 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 862719007625 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 862719007626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719007627 active site 862719007628 motif I; other site 862719007629 motif II; other site 862719007630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719007631 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 862719007632 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 862719007633 putative ADP-binding pocket [chemical binding]; other site 862719007634 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719007635 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862719007636 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 862719007637 Evidence 7 : Gene remnant; Product type pe : putative enzyme 862719007638 Evidence 7 : Gene remnant; Product type pe : putative enzyme 862719007639 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719007640 MarR family; Region: MarR; pfam01047 862719007641 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 862719007642 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 862719007643 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 862719007644 putative catalytic site [active] 862719007645 putative phosphate binding site [ion binding]; other site 862719007646 active site 862719007647 metal binding site A [ion binding]; metal-binding site 862719007648 DNA binding site [nucleotide binding] 862719007649 putative AP binding site [nucleotide binding]; other site 862719007650 putative metal binding site B [ion binding]; other site 862719007651 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719007652 catalytic core [active] 862719007653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 862719007654 Peptidase M15; Region: Peptidase_M15_3; cl01194 862719007655 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 862719007656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719007657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007658 active site 862719007659 phosphorylation site [posttranslational modification] 862719007660 intermolecular recognition site; other site 862719007661 dimerization interface [polypeptide binding]; other site 862719007662 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719007663 DNA binding site [nucleotide binding] 862719007664 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 862719007665 dimerization interface [polypeptide binding]; other site 862719007666 active site 862719007667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 862719007668 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 862719007669 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862719007670 catalytic residue [active] 862719007671 Gram-negative porin; Region: Porin_4; pfam13609 862719007672 Gram-negative porin; Region: Porin_4; pfam13609 862719007673 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 862719007674 trimer interface [polypeptide binding]; other site 862719007675 eyelet of channel; other site 862719007676 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 862719007677 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 862719007678 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 862719007679 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 862719007680 HIGH motif; other site 862719007681 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 862719007682 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719007683 active site 862719007684 KMSKS motif; other site 862719007685 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 862719007686 tRNA binding surface [nucleotide binding]; other site 862719007687 Lipopolysaccharide-assembly; Region: LptE; cl01125 862719007688 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 862719007689 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 862719007690 TspO/MBR family; Region: TspO_MBR; cl01379 862719007691 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 862719007692 GIY-YIG motif/motif A; other site 862719007693 Winged helix-turn helix; Region: HTH_29; pfam13551 862719007694 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719007695 Homeodomain-like domain; Region: HTH_32; pfam13565 862719007696 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719007697 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 862719007698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719007699 FeS/SAM binding site; other site 862719007700 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 862719007701 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 862719007702 active site 862719007703 catalytic site [active] 862719007704 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 862719007705 FMN binding site [chemical binding]; other site 862719007706 substrate binding site [chemical binding]; other site 862719007707 putative catalytic residue [active] 862719007708 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 862719007709 metal binding site 2 [ion binding]; metal-binding site 862719007710 putative DNA binding helix; other site 862719007711 metal binding site 1 [ion binding]; metal-binding site 862719007712 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719007713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007714 putative active site [active] 862719007715 heme pocket [chemical binding]; other site 862719007716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719007717 dimer interface [polypeptide binding]; other site 862719007718 phosphorylation site [posttranslational modification] 862719007719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007720 ATP binding site [chemical binding]; other site 862719007721 Mg2+ binding site [ion binding]; other site 862719007722 G-X-G motif; other site 862719007723 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 862719007724 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 862719007725 Na binding site [ion binding]; other site 862719007726 Protein of unknown function, DUF485; Region: DUF485; pfam04341 862719007727 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719007728 Cache domain; Region: Cache_2; cl07034 862719007729 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862719007730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719007731 dimerization interface [polypeptide binding]; other site 862719007732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719007734 putative active site [active] 862719007735 heme pocket [chemical binding]; other site 862719007736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719007737 dimer interface [polypeptide binding]; other site 862719007738 phosphorylation site [posttranslational modification] 862719007739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007740 ATP binding site [chemical binding]; other site 862719007741 Mg2+ binding site [ion binding]; other site 862719007742 G-X-G motif; other site 862719007743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007744 Response regulator receiver domain; Region: Response_reg; pfam00072 862719007745 active site 862719007746 phosphorylation site [posttranslational modification] 862719007747 intermolecular recognition site; other site 862719007748 dimerization interface [polypeptide binding]; other site 862719007749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719007750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007751 active site 862719007752 phosphorylation site [posttranslational modification] 862719007753 intermolecular recognition site; other site 862719007754 dimerization interface [polypeptide binding]; other site 862719007755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719007756 DNA binding site [nucleotide binding] 862719007757 acyl-CoA synthetase; Validated; Region: PRK08162 862719007758 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 862719007759 acyl-activating enzyme (AAE) consensus motif; other site 862719007760 putative active site [active] 862719007761 AMP binding site [chemical binding]; other site 862719007762 putative CoA binding site [chemical binding]; other site 862719007763 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 862719007764 Ligand binding site [chemical binding]; other site 862719007765 Electron transfer flavoprotein domain; Region: ETF; pfam01012 862719007766 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 862719007767 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 862719007768 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 862719007769 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 862719007770 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 862719007771 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719007772 active site 862719007773 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 862719007774 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 862719007775 pseudouridine synthase; Region: TIGR00093 862719007776 active site 862719007777 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 862719007778 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 862719007779 putative ligand binding site [chemical binding]; other site 862719007780 NAD binding site [chemical binding]; other site 862719007781 dimerization interface [polypeptide binding]; other site 862719007782 catalytic site [active] 862719007783 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719007784 Winged helix-turn helix; Region: HTH_29; pfam13551 862719007785 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719007786 Homeodomain-like domain; Region: HTH_32; pfam13565 862719007787 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 862719007788 ABC1 family; Region: ABC1; cl17513 862719007789 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 862719007790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719007791 S-adenosylmethionine binding site [chemical binding]; other site 862719007792 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 862719007793 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719007794 active site 862719007795 DNA binding site [nucleotide binding] 862719007796 Int/Topo IB signature motif; other site 862719007797 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 862719007798 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 862719007799 23S rRNA binding site [nucleotide binding]; other site 862719007800 L21 binding site [polypeptide binding]; other site 862719007801 L13 binding site [polypeptide binding]; other site 862719007802 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 862719007803 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 862719007804 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 862719007805 dimer interface [polypeptide binding]; other site 862719007806 motif 1; other site 862719007807 active site 862719007808 motif 2; other site 862719007809 motif 3; other site 862719007810 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 862719007811 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 862719007812 putative tRNA-binding site [nucleotide binding]; other site 862719007813 B3/4 domain; Region: B3_4; pfam03483 862719007814 tRNA synthetase B5 domain; Region: B5; smart00874 862719007815 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 862719007816 dimer interface [polypeptide binding]; other site 862719007817 motif 1; other site 862719007818 motif 3; other site 862719007819 motif 2; other site 862719007820 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 862719007821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007822 Response regulator receiver domain; Region: Response_reg; pfam00072 862719007823 active site 862719007824 phosphorylation site [posttranslational modification] 862719007825 intermolecular recognition site; other site 862719007826 dimerization interface [polypeptide binding]; other site 862719007827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719007828 active site 862719007829 phosphorylation site [posttranslational modification] 862719007830 intermolecular recognition site; other site 862719007831 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719007832 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 862719007833 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719007834 Zn2+ binding site [ion binding]; other site 862719007835 Mg2+ binding site [ion binding]; other site 862719007836 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 862719007837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719007838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719007839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719007840 dimerization interface [polypeptide binding]; other site 862719007841 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 862719007842 active site 862719007843 homodimer interface [polypeptide binding]; other site 862719007844 GTP-binding protein LepA; Provisional; Region: PRK05433 862719007845 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 862719007846 G1 box; other site 862719007847 putative GEF interaction site [polypeptide binding]; other site 862719007848 GTP/Mg2+ binding site [chemical binding]; other site 862719007849 Switch I region; other site 862719007850 G2 box; other site 862719007851 G3 box; other site 862719007852 Switch II region; other site 862719007853 G4 box; other site 862719007854 G5 box; other site 862719007855 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 862719007856 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 862719007857 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 862719007858 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719007859 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719007860 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719007861 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719007862 glycogen synthase; Provisional; Region: glgA; PRK00654 862719007863 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 862719007864 ADP-binding pocket [chemical binding]; other site 862719007865 homodimer interface [polypeptide binding]; other site 862719007866 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 862719007867 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 862719007868 ligand binding site; other site 862719007869 oligomer interface; other site 862719007870 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 862719007871 dimer interface [polypeptide binding]; other site 862719007872 N-terminal domain interface [polypeptide binding]; other site 862719007873 sulfate 1 binding site; other site 862719007874 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 862719007875 Pirin-related protein [General function prediction only]; Region: COG1741 862719007876 Pirin; Region: Pirin; pfam02678 862719007877 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 862719007878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719007879 putative active site [active] 862719007880 PAS fold; Region: PAS_3; pfam08447 862719007881 heme pocket [chemical binding]; other site 862719007882 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719007883 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719007884 metal binding site [ion binding]; metal-binding site 862719007885 active site 862719007886 I-site; other site 862719007887 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719007888 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 862719007889 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 862719007890 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 862719007891 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 862719007892 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 862719007893 active site 862719007894 DNA binding site [nucleotide binding] 862719007895 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 862719007896 DNA binding site [nucleotide binding] 862719007897 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 862719007898 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 862719007899 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 862719007900 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 862719007901 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719007902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719007903 putative DNA binding site [nucleotide binding]; other site 862719007904 putative Zn2+ binding site [ion binding]; other site 862719007905 AsnC family; Region: AsnC_trans_reg; pfam01037 862719007906 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 862719007907 Chromate transporter; Region: Chromate_transp; pfam02417 862719007908 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 862719007909 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 862719007910 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 862719007911 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 862719007912 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 862719007913 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 862719007914 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719007915 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 862719007916 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 862719007917 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719007918 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719007919 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 862719007920 IMP binding site; other site 862719007921 dimer interface [polypeptide binding]; other site 862719007922 partial ornithine binding site; other site 862719007923 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 862719007924 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 862719007925 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 862719007926 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 862719007927 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 862719007928 [4Fe-4S] binding site [ion binding]; other site 862719007929 molybdopterin cofactor binding site; other site 862719007930 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 862719007931 molybdopterin cofactor binding site; other site 862719007932 NapD protein; Region: NapD; pfam03927 862719007933 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 862719007934 MgtC family; Region: MgtC; pfam02308 862719007935 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 862719007936 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 862719007937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719007938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719007939 dimer interface [polypeptide binding]; other site 862719007940 phosphorylation site [posttranslational modification] 862719007941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007942 ATP binding site [chemical binding]; other site 862719007943 Mg2+ binding site [ion binding]; other site 862719007944 G-X-G motif; other site 862719007945 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 862719007946 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 862719007947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719007948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719007949 dimer interface [polypeptide binding]; other site 862719007950 phosphorylation site [posttranslational modification] 862719007951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719007952 ATP binding site [chemical binding]; other site 862719007953 Mg2+ binding site [ion binding]; other site 862719007954 G-X-G motif; other site 862719007955 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 862719007956 DinB family; Region: DinB; cl17821 862719007957 DinB superfamily; Region: DinB_2; pfam12867 862719007958 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 862719007959 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 862719007960 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 862719007961 PAS fold; Region: PAS_4; pfam08448 862719007962 methionine sulfoxide reductase A; Provisional; Region: PRK00058 862719007963 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 862719007964 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 862719007965 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 862719007966 Predicted membrane protein [Function unknown]; Region: COG1238 862719007967 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 862719007968 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 862719007969 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 862719007970 glucokinase, proteobacterial type; Region: glk; TIGR00749 862719007971 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 862719007972 nucleotide binding site [chemical binding]; other site 862719007973 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 862719007974 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 862719007975 active site 862719007976 homotetramer interface [polypeptide binding]; other site 862719007977 N-formylglutamate amidohydrolase; Region: FGase; cl01522 862719007978 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 862719007979 TIGR02300 family protein; Region: FYDLN_acid 862719007980 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 862719007981 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 862719007982 hinge; other site 862719007983 active site 862719007984 cytidylate kinase; Provisional; Region: cmk; PRK00023 862719007985 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 862719007986 CMP-binding site; other site 862719007987 The sites determining sugar specificity; other site 862719007988 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 862719007989 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 862719007990 RNA binding site [nucleotide binding]; other site 862719007991 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 862719007992 RNA binding site [nucleotide binding]; other site 862719007993 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 862719007994 RNA binding site [nucleotide binding]; other site 862719007995 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 862719007996 RNA binding site [nucleotide binding]; other site 862719007997 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 862719007998 RNA binding site [nucleotide binding]; other site 862719007999 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 862719008000 RNA binding site [nucleotide binding]; other site 862719008001 PRC-barrel domain; Region: PRC; pfam05239 862719008002 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 862719008003 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 862719008004 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 862719008005 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 862719008006 active site 862719008007 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 862719008008 TSCPD domain; Region: TSCPD; pfam12637 862719008009 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862719008010 GAF domain; Region: GAF; pfam01590 862719008011 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719008012 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719008013 metal binding site [ion binding]; metal-binding site 862719008014 active site 862719008015 I-site; other site 862719008016 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719008017 pyruvate phosphate dikinase; Provisional; Region: PRK09279 862719008018 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 862719008019 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 862719008020 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 862719008021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 862719008022 sequence-specific DNA binding site [nucleotide binding]; other site 862719008023 salt bridge; other site 862719008024 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 862719008025 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 862719008026 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719008027 Predicted transcriptional regulator [Transcription]; Region: COG4190 862719008028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719008029 putative DNA binding site [nucleotide binding]; other site 862719008030 putative Zn2+ binding site [ion binding]; other site 862719008031 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 862719008032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719008033 ATP binding site [chemical binding]; other site 862719008034 putative Mg++ binding site [ion binding]; other site 862719008035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719008036 nucleotide binding region [chemical binding]; other site 862719008037 ATP-binding site [chemical binding]; other site 862719008038 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 862719008039 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 862719008040 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 862719008041 diiron binding motif [ion binding]; other site 862719008042 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719008043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008044 active site 862719008045 phosphorylation site [posttranslational modification] 862719008046 intermolecular recognition site; other site 862719008047 dimerization interface [polypeptide binding]; other site 862719008048 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 862719008049 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 862719008050 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 862719008051 anti sigma factor interaction site; other site 862719008052 regulatory phosphorylation site [posttranslational modification]; other site 862719008053 HRDC domain; Region: HRDC; cl02578 862719008054 formyl-coenzyme A transferase; Provisional; Region: PRK05398 862719008055 CoA-transferase family III; Region: CoA_transf_3; pfam02515 862719008056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719008057 PAS domain; Region: PAS_9; pfam13426 862719008058 putative active site [active] 862719008059 heme pocket [chemical binding]; other site 862719008060 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 862719008061 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862719008062 E3 interaction surface; other site 862719008063 lipoyl attachment site [posttranslational modification]; other site 862719008064 e3 binding domain; Region: E3_binding; pfam02817 862719008065 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 862719008066 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 862719008067 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 862719008068 TPP-binding site [chemical binding]; other site 862719008069 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 862719008070 dimer interface [polypeptide binding]; other site 862719008071 PYR/PP interface [polypeptide binding]; other site 862719008072 TPP binding site [chemical binding]; other site 862719008073 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 862719008074 CoA binding domain; Region: CoA_binding; pfam02629 862719008075 CoA-ligase; Region: Ligase_CoA; pfam00549 862719008076 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 862719008077 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 862719008078 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 862719008079 CoA-ligase; Region: Ligase_CoA; pfam00549 862719008080 malate dehydrogenase; Reviewed; Region: PRK06223 862719008081 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 862719008082 NAD(P) binding site [chemical binding]; other site 862719008083 dimer interface [polypeptide binding]; other site 862719008084 tetramer (dimer of dimers) interface [polypeptide binding]; other site 862719008085 substrate binding site [chemical binding]; other site 862719008086 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 862719008087 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 862719008088 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719008089 active site 862719008090 nucleotide binding site [chemical binding]; other site 862719008091 HIGH motif; other site 862719008092 KMSKS motif; other site 862719008093 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 862719008094 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719008095 dimerization interface [polypeptide binding]; other site 862719008096 putative DNA binding site [nucleotide binding]; other site 862719008097 putative Zn2+ binding site [ion binding]; other site 862719008098 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 862719008099 putative hydrophobic ligand binding site [chemical binding]; other site 862719008100 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719008101 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719008102 substrate binding pocket [chemical binding]; other site 862719008103 membrane-bound complex binding site; other site 862719008104 hinge residues; other site 862719008105 PAS domain S-box; Region: sensory_box; TIGR00229 862719008106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719008107 putative active site [active] 862719008108 heme pocket [chemical binding]; other site 862719008109 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719008110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719008111 metal binding site [ion binding]; metal-binding site 862719008112 active site 862719008113 I-site; other site 862719008114 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719008115 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 862719008116 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 862719008117 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 862719008118 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 862719008119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 862719008120 nucleotide binding region [chemical binding]; other site 862719008121 SEC-C motif; Region: SEC-C; pfam02810 862719008122 SurA N-terminal domain; Region: SurA_N_3; cl07813 862719008123 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 862719008124 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 862719008125 heterotetramer interface [polypeptide binding]; other site 862719008126 active site pocket [active] 862719008127 cleavage site 862719008128 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 862719008129 active site 862719008130 8-oxo-dGMP binding site [chemical binding]; other site 862719008131 nudix motif; other site 862719008132 metal binding site [ion binding]; metal-binding site 862719008133 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 862719008134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719008135 ATP binding site [chemical binding]; other site 862719008136 putative Mg++ binding site [ion binding]; other site 862719008137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719008138 nucleotide binding region [chemical binding]; other site 862719008139 ATP-binding site [chemical binding]; other site 862719008140 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 862719008141 HRDC domain; Region: HRDC; pfam00570 862719008142 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719008143 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 862719008144 active site 862719008145 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 862719008146 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 862719008147 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 862719008148 putative MPT binding site; other site 862719008149 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862719008150 active site residue [active] 862719008151 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719008152 putative DNA binding site [nucleotide binding]; other site 862719008153 dimerization interface [polypeptide binding]; other site 862719008154 putative Zn2+ binding site [ion binding]; other site 862719008155 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 862719008156 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 862719008157 diiron binding motif [ion binding]; other site 862719008158 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 862719008159 malate synthase A; Region: malate_syn_A; TIGR01344 862719008160 active site 862719008161 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 862719008162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719008163 Walker A motif; other site 862719008164 ATP binding site [chemical binding]; other site 862719008165 Walker B motif; other site 862719008166 arginine finger; other site 862719008167 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 862719008168 phage shock protein A; Region: phageshock_pspA; TIGR02977 862719008169 Phage shock protein B; Region: PspB; pfam06667 862719008170 PspC domain; Region: PspC; cl00864 862719008171 phage shock protein C; Region: phageshock_pspC; TIGR02978 862719008172 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 862719008173 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 862719008174 MAPEG family; Region: MAPEG; pfam01124 862719008175 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719008176 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719008177 active site 862719008178 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862719008179 Right handed beta helix region; Region: Beta_helix; pfam13229 862719008180 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 862719008181 HemY protein N-terminus; Region: HemY_N; pfam07219 862719008182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 862719008183 TPR motif; other site 862719008184 binding surface 862719008185 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 862719008186 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 862719008187 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 862719008188 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 862719008189 active site 862719008190 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 862719008191 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 862719008192 domain interfaces; other site 862719008193 active site 862719008194 UGMP family protein; Validated; Region: PRK09604 862719008195 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 862719008196 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 862719008197 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 862719008198 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 862719008199 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 862719008200 LytTr DNA-binding domain; Region: LytTR; smart00850 862719008201 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 862719008202 Predicted transcriptional regulator [Transcription]; Region: COG2378 862719008203 HTH domain; Region: HTH_11; pfam08279 862719008204 WYL domain; Region: WYL; pfam13280 862719008205 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 862719008206 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719008207 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 862719008208 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 862719008209 putative active site [active] 862719008210 putative PHP Thumb interface [polypeptide binding]; other site 862719008211 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 862719008212 generic binding surface I; other site 862719008213 generic binding surface II; other site 862719008214 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719008215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719008216 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719008217 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719008218 metal binding site [ion binding]; metal-binding site 862719008219 active site 862719008220 I-site; other site 862719008221 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 862719008222 potassium uptake protein; Region: kup; TIGR00794 862719008223 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 862719008224 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 862719008225 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 862719008226 dimerization interface [polypeptide binding]; other site 862719008227 domain crossover interface; other site 862719008228 redox-dependent activation switch; other site 862719008229 ornithine carbamoyltransferase; Provisional; Region: PRK00779 862719008230 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 862719008231 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 862719008232 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 862719008233 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719008234 inhibitor-cofactor binding pocket; inhibition site 862719008235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719008236 catalytic residue [active] 862719008237 ABC-2 type transporter; Region: ABC2_membrane; cl17235 862719008238 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 862719008239 RecX family; Region: RecX; pfam02631 862719008240 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 862719008241 membrane ATPase/protein kinase; Provisional; Region: PRK09435 862719008242 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 862719008243 Walker A; other site 862719008244 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 862719008245 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719008246 Walker A/P-loop; other site 862719008247 ATP binding site [chemical binding]; other site 862719008248 Q-loop/lid; other site 862719008249 ABC transporter signature motif; other site 862719008250 Walker B; other site 862719008251 D-loop; other site 862719008252 H-loop/switch region; other site 862719008253 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 862719008254 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719008255 Walker A/P-loop; other site 862719008256 ATP binding site [chemical binding]; other site 862719008257 Q-loop/lid; other site 862719008258 ABC transporter signature motif; other site 862719008259 Walker B; other site 862719008260 D-loop; other site 862719008261 H-loop/switch region; other site 862719008262 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 862719008263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719008264 dimer interface [polypeptide binding]; other site 862719008265 conserved gate region; other site 862719008266 ABC-ATPase subunit interface; other site 862719008267 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 862719008268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719008269 dimer interface [polypeptide binding]; other site 862719008270 conserved gate region; other site 862719008271 putative PBP binding loops; other site 862719008272 ABC-ATPase subunit interface; other site 862719008273 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 862719008274 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 862719008275 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 862719008276 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 862719008277 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 862719008278 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 862719008279 active site 862719008280 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 862719008281 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 862719008282 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 862719008283 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 862719008284 putative NADH binding site [chemical binding]; other site 862719008285 putative active site [active] 862719008286 nudix motif; other site 862719008287 putative metal binding site [ion binding]; other site 862719008288 Domain of unknown function DUF29; Region: DUF29; pfam01724 862719008289 prephenate dehydratase; Provisional; Region: PRK11899 862719008290 Prephenate dehydratase; Region: PDT; pfam00800 862719008291 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 862719008292 putative L-Phe binding site [chemical binding]; other site 862719008293 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 862719008294 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 862719008295 Ligand binding site; other site 862719008296 oligomer interface; other site 862719008297 Cytochrome c2 [Energy production and conversion]; Region: COG3474 862719008298 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 862719008299 nudix motif; other site 862719008300 Response regulator receiver domain; Region: Response_reg; pfam00072 862719008301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008302 active site 862719008303 phosphorylation site [posttranslational modification] 862719008304 intermolecular recognition site; other site 862719008305 dimerization interface [polypeptide binding]; other site 862719008306 PrkA family serine protein kinase; Provisional; Region: PRK15455 862719008307 AAA ATPase domain; Region: AAA_16; pfam13191 862719008308 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 862719008309 hypothetical protein; Provisional; Region: PRK05325 862719008310 SpoVR family protein; Provisional; Region: PRK11767 862719008311 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 862719008312 PilZ domain; Region: PilZ; pfam07238 862719008313 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 862719008314 Beta-lactamase; Region: Beta-lactamase; pfam00144 862719008315 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 862719008316 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 862719008317 acyl-activating enzyme (AAE) consensus motif; other site 862719008318 putative AMP binding site [chemical binding]; other site 862719008319 putative active site [active] 862719008320 putative CoA binding site [chemical binding]; other site 862719008321 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 862719008322 lipoate-protein ligase B; Provisional; Region: PRK14341 862719008323 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 862719008324 anti sigma factor interaction site; other site 862719008325 regulatory phosphorylation site [posttranslational modification]; other site 862719008326 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 862719008327 MgtE intracellular N domain; Region: MgtE_N; smart00924 862719008328 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 862719008329 Divalent cation transporter; Region: MgtE; pfam01769 862719008330 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 862719008331 CoenzymeA binding site [chemical binding]; other site 862719008332 subunit interaction site [polypeptide binding]; other site 862719008333 PHB binding site; other site 862719008334 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 862719008335 ThiS interaction site; other site 862719008336 putative active site [active] 862719008337 tetramer interface [polypeptide binding]; other site 862719008338 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 862719008339 thiS-thiF/thiG interaction site; other site 862719008340 hydroxyglutarate oxidase; Provisional; Region: PRK11728 862719008341 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 862719008342 FIST N domain; Region: FIST; smart00897 862719008343 FIST C domain; Region: FIST_C; pfam10442 862719008344 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719008345 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719008346 dimer interface [polypeptide binding]; other site 862719008347 putative CheW interface [polypeptide binding]; other site 862719008348 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 862719008349 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719008350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008351 active site 862719008352 dimerization interface [polypeptide binding]; other site 862719008353 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719008354 DNA binding site [nucleotide binding] 862719008355 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 862719008356 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 862719008357 putative catalytic residue [active] 862719008358 Ion channel; Region: Ion_trans_2; pfam07885 862719008359 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 862719008360 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 862719008361 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 862719008362 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 862719008363 active site 862719008364 HIGH motif; other site 862719008365 dimer interface [polypeptide binding]; other site 862719008366 KMSKS motif; other site 862719008367 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862719008368 RNA binding surface [nucleotide binding]; other site 862719008369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 862719008370 Peptidase M15; Region: Peptidase_M15_3; cl01194 862719008371 DNA repair protein radc; Region: radc; TIGR00608 862719008372 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 862719008373 MPN+ (JAMM) motif; other site 862719008374 Zinc-binding site [ion binding]; other site 862719008375 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 862719008376 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 862719008377 ligand binding site [chemical binding]; other site 862719008378 NAD binding site [chemical binding]; other site 862719008379 dimerization interface [polypeptide binding]; other site 862719008380 catalytic site [active] 862719008381 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 862719008382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719008383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719008384 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 862719008385 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 862719008386 FAD binding domain; Region: FAD_binding_4; pfam01565 862719008387 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 862719008388 FAD binding domain; Region: FAD_binding_4; pfam01565 862719008389 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 862719008390 Cysteine-rich domain; Region: CCG; pfam02754 862719008391 Cysteine-rich domain; Region: CCG; pfam02754 862719008392 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 862719008393 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 862719008394 Uncharacterized conserved protein [Function unknown]; Region: COG1801 862719008395 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 862719008396 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 862719008397 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 862719008398 active site 862719008399 NAD binding site [chemical binding]; other site 862719008400 metal binding site [ion binding]; metal-binding site 862719008401 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 862719008402 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719008403 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719008404 active site 862719008405 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 862719008406 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862719008407 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719008408 catalytic residue [active] 862719008409 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 862719008410 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 862719008411 putative dimer interface [polypeptide binding]; other site 862719008412 active site pocket [active] 862719008413 putative cataytic base [active] 862719008414 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 862719008415 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 862719008416 metal binding site [ion binding]; metal-binding site 862719008417 dimer interface [polypeptide binding]; other site 862719008418 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 862719008419 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 862719008420 trimer interface [polypeptide binding]; other site 862719008421 active site 862719008422 substrate binding site [chemical binding]; other site 862719008423 CoA binding site [chemical binding]; other site 862719008424 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 862719008425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719008426 motif II; other site 862719008427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719008428 PAS domain; Region: PAS_9; pfam13426 862719008429 putative active site [active] 862719008430 heme pocket [chemical binding]; other site 862719008431 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719008432 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719008433 metal binding site [ion binding]; metal-binding site 862719008434 active site 862719008435 I-site; other site 862719008436 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 862719008437 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 862719008438 HSP70 interaction site [polypeptide binding]; other site 862719008439 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719008440 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719008441 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719008442 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719008443 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719008444 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719008445 signal recognition particle protein; Provisional; Region: PRK10867 862719008446 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 862719008447 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 862719008448 P loop; other site 862719008449 GTP binding site [chemical binding]; other site 862719008450 Signal peptide binding domain; Region: SRP_SPB; pfam02978 862719008451 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 862719008452 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14592 862719008453 RimM N-terminal domain; Region: RimM; pfam01782 862719008454 PRC-barrel domain; Region: PRC; pfam05239 862719008455 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 862719008456 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 862719008457 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 862719008458 Ribonuclease P; Region: Ribonuclease_P; pfam00825 862719008459 hypothetical protein; Validated; Region: PRK00041 862719008460 membrane protein insertase; Provisional; Region: PRK01318 862719008461 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 862719008462 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 862719008463 G1 box; other site 862719008464 GTP/Mg2+ binding site [chemical binding]; other site 862719008465 Switch I region; other site 862719008466 G2 box; other site 862719008467 G3 box; other site 862719008468 Switch II region; other site 862719008469 G4 box; other site 862719008470 G5 box; other site 862719008471 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 862719008472 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 862719008473 feedback inhibition sensing region; other site 862719008474 homohexameric interface [polypeptide binding]; other site 862719008475 nucleotide binding site [chemical binding]; other site 862719008476 N-acetyl-L-glutamate binding site [chemical binding]; other site 862719008477 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 862719008478 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 862719008479 Cl binding site [ion binding]; other site 862719008480 oligomer interface [polypeptide binding]; other site 862719008481 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 862719008482 ThiC-associated domain; Region: ThiC-associated; pfam13667 862719008483 ThiC family; Region: ThiC; pfam01964 862719008484 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 862719008485 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 862719008486 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 862719008487 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 862719008488 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 862719008489 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 862719008490 AMIN domain; Region: AMIN; pfam11741 862719008491 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 862719008492 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 862719008493 active site 862719008494 metal binding site [ion binding]; metal-binding site 862719008495 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 862719008496 Transglycosylase; Region: Transgly; pfam00912 862719008497 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 862719008498 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 862719008499 catalytic triad [active] 862719008500 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 862719008501 peptide chain release factor 2; Provisional; Region: PRK07342 862719008502 This domain is found in peptide chain release factors; Region: PCRF; smart00937 862719008503 RF-1 domain; Region: RF-1; pfam00472 862719008504 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 862719008505 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 862719008506 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 862719008507 fructokinase; Reviewed; Region: PRK09557 862719008508 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 862719008509 nucleotide binding site [chemical binding]; other site 862719008510 Glucokinase; Region: Glucokinase; cl17310 862719008511 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 862719008512 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 862719008513 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862719008514 Caspase domain; Region: Peptidase_C14; pfam00656 862719008515 MORN repeat; Region: MORN; pfam02493 862719008516 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 862719008517 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719008518 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 862719008519 Walker A/P-loop; other site 862719008520 ATP binding site [chemical binding]; other site 862719008521 Q-loop/lid; other site 862719008522 ABC transporter signature motif; other site 862719008523 Walker B; other site 862719008524 D-loop; other site 862719008525 H-loop/switch region; other site 862719008526 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719008527 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 862719008528 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719008529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719008530 dimer interface [polypeptide binding]; other site 862719008531 conserved gate region; other site 862719008532 putative PBP binding loops; other site 862719008533 ABC-ATPase subunit interface; other site 862719008534 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719008535 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 862719008536 Walker A/P-loop; other site 862719008537 ATP binding site [chemical binding]; other site 862719008538 Q-loop/lid; other site 862719008539 ABC transporter signature motif; other site 862719008540 Walker B; other site 862719008541 D-loop; other site 862719008542 H-loop/switch region; other site 862719008543 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719008544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719008545 dimer interface [polypeptide binding]; other site 862719008546 conserved gate region; other site 862719008547 ABC-ATPase subunit interface; other site 862719008548 NMT1/THI5 like; Region: NMT1; pfam09084 862719008549 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719008550 substrate binding pocket [chemical binding]; other site 862719008551 membrane-bound complex binding site; other site 862719008552 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719008553 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719008554 Walker A/P-loop; other site 862719008555 ATP binding site [chemical binding]; other site 862719008556 Q-loop/lid; other site 862719008557 ABC transporter signature motif; other site 862719008558 Walker B; other site 862719008559 D-loop; other site 862719008560 H-loop/switch region; other site 862719008561 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719008562 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719008563 Walker A/P-loop; other site 862719008564 ATP binding site [chemical binding]; other site 862719008565 Q-loop/lid; other site 862719008566 ABC transporter signature motif; other site 862719008567 Walker B; other site 862719008568 D-loop; other site 862719008569 H-loop/switch region; other site 862719008570 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719008571 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719008572 TM-ABC transporter signature motif; other site 862719008573 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719008574 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719008575 TM-ABC transporter signature motif; other site 862719008576 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719008577 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 862719008578 putative ligand binding site [chemical binding]; other site 862719008579 Transcriptional regulators [Transcription]; Region: MarR; COG1846 862719008580 MarR family; Region: MarR; pfam01047 862719008581 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 862719008582 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 862719008583 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 862719008584 SLBB domain; Region: SLBB; pfam10531 862719008585 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 862719008586 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 862719008587 catalytic residues [active] 862719008588 catalytic nucleophile [active] 862719008589 Recombinase; Region: Recombinase; pfam07508 862719008590 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719008591 active site 862719008592 Int/Topo IB signature motif; other site 862719008593 DNA binding site [nucleotide binding] 862719008594 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719008595 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719008596 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 862719008597 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 862719008598 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 862719008599 elongation factor Tu; Reviewed; Region: PRK00049 862719008600 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 862719008601 G1 box; other site 862719008602 GEF interaction site [polypeptide binding]; other site 862719008603 GTP/Mg2+ binding site [chemical binding]; other site 862719008604 Switch I region; other site 862719008605 G2 box; other site 862719008606 G3 box; other site 862719008607 Switch II region; other site 862719008608 G4 box; other site 862719008609 G5 box; other site 862719008610 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 862719008611 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 862719008612 Antibiotic Binding Site [chemical binding]; other site 862719008613 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 862719008614 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 862719008615 putative homodimer interface [polypeptide binding]; other site 862719008616 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 862719008617 heterodimer interface [polypeptide binding]; other site 862719008618 homodimer interface [polypeptide binding]; other site 862719008619 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 862719008620 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 862719008621 23S rRNA interface [nucleotide binding]; other site 862719008622 L7/L12 interface [polypeptide binding]; other site 862719008623 putative thiostrepton binding site; other site 862719008624 L25 interface [polypeptide binding]; other site 862719008625 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 862719008626 mRNA/rRNA interface [nucleotide binding]; other site 862719008627 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 862719008628 23S rRNA interface [nucleotide binding]; other site 862719008629 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 862719008630 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 862719008631 L11 interface [polypeptide binding]; other site 862719008632 putative EF-Tu interaction site [polypeptide binding]; other site 862719008633 putative EF-G interaction site [polypeptide binding]; other site 862719008634 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 862719008635 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 862719008636 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 862719008637 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 862719008638 RPB11 interaction site [polypeptide binding]; other site 862719008639 RPB12 interaction site [polypeptide binding]; other site 862719008640 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 862719008641 RPB1 interaction site [polypeptide binding]; other site 862719008642 RPB11 interaction site [polypeptide binding]; other site 862719008643 RPB10 interaction site [polypeptide binding]; other site 862719008644 RPB3 interaction site [polypeptide binding]; other site 862719008645 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 862719008646 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 862719008647 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 862719008648 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 862719008649 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 862719008650 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 862719008651 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 862719008652 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 862719008653 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 862719008654 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 862719008655 DNA binding site [nucleotide binding] 862719008656 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 862719008657 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 862719008658 S17 interaction site [polypeptide binding]; other site 862719008659 S8 interaction site; other site 862719008660 16S rRNA interaction site [nucleotide binding]; other site 862719008661 streptomycin interaction site [chemical binding]; other site 862719008662 23S rRNA interaction site [nucleotide binding]; other site 862719008663 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 862719008664 30S ribosomal protein S7; Validated; Region: PRK05302 862719008665 elongation factor G; Reviewed; Region: PRK00007 862719008666 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 862719008667 G1 box; other site 862719008668 putative GEF interaction site [polypeptide binding]; other site 862719008669 GTP/Mg2+ binding site [chemical binding]; other site 862719008670 Switch I region; other site 862719008671 G2 box; other site 862719008672 G3 box; other site 862719008673 Switch II region; other site 862719008674 G4 box; other site 862719008675 G5 box; other site 862719008676 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 862719008677 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 862719008678 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 862719008679 elongation factor Tu; Reviewed; Region: PRK00049 862719008680 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 862719008681 G1 box; other site 862719008682 GEF interaction site [polypeptide binding]; other site 862719008683 GTP/Mg2+ binding site [chemical binding]; other site 862719008684 Switch I region; other site 862719008685 G2 box; other site 862719008686 G3 box; other site 862719008687 Switch II region; other site 862719008688 G4 box; other site 862719008689 G5 box; other site 862719008690 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 862719008691 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 862719008692 Antibiotic Binding Site [chemical binding]; other site 862719008693 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 862719008694 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 862719008695 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 862719008696 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 862719008697 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 862719008698 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 862719008699 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 862719008700 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 862719008701 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 862719008702 putative translocon binding site; other site 862719008703 protein-rRNA interface [nucleotide binding]; other site 862719008704 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 862719008705 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 862719008706 G-X-X-G motif; other site 862719008707 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 862719008708 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 862719008709 23S rRNA interface [nucleotide binding]; other site 862719008710 5S rRNA interface [nucleotide binding]; other site 862719008711 putative antibiotic binding site [chemical binding]; other site 862719008712 L25 interface [polypeptide binding]; other site 862719008713 L27 interface [polypeptide binding]; other site 862719008714 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 862719008715 putative translocon interaction site; other site 862719008716 23S rRNA interface [nucleotide binding]; other site 862719008717 signal recognition particle (SRP54) interaction site; other site 862719008718 L23 interface [polypeptide binding]; other site 862719008719 trigger factor interaction site; other site 862719008720 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 862719008721 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 862719008722 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 862719008723 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 862719008724 RNA binding site [nucleotide binding]; other site 862719008725 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 862719008726 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 862719008727 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 862719008728 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 862719008729 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 862719008730 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 862719008731 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 862719008732 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 862719008733 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 862719008734 5S rRNA interface [nucleotide binding]; other site 862719008735 23S rRNA interface [nucleotide binding]; other site 862719008736 L5 interface [polypeptide binding]; other site 862719008737 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 862719008738 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 862719008739 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 862719008740 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 862719008741 23S rRNA binding site [nucleotide binding]; other site 862719008742 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 862719008743 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 862719008744 SecY translocase; Region: SecY; pfam00344 862719008745 adenylate kinase; Reviewed; Region: adk; PRK00279 862719008746 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 862719008747 AMP-binding site [chemical binding]; other site 862719008748 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 862719008749 Transcriptional regulators [Transcription]; Region: FadR; COG2186 862719008750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719008751 DNA-binding site [nucleotide binding]; DNA binding site 862719008752 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 862719008753 EamA-like transporter family; Region: EamA; pfam00892 862719008754 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 862719008755 Agenet domain; Region: Agenet; pfam05641 862719008756 N-formylglutamate amidohydrolase; Region: FGase; cl01522 862719008757 carboxylate-amine ligase; Provisional; Region: PRK13515 862719008758 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 862719008759 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 862719008760 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 862719008761 homodimer interface [polypeptide binding]; other site 862719008762 substrate-cofactor binding pocket; other site 862719008763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719008764 catalytic residue [active] 862719008765 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862719008766 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719008767 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 862719008768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719008769 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862719008770 putative active site [active] 862719008771 heme pocket [chemical binding]; other site 862719008772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719008773 putative active site [active] 862719008774 heme pocket [chemical binding]; other site 862719008775 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719008776 PAS domain; Region: PAS; smart00091 862719008777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719008778 dimer interface [polypeptide binding]; other site 862719008779 phosphorylation site [posttranslational modification] 862719008780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719008781 ATP binding site [chemical binding]; other site 862719008782 Mg2+ binding site [ion binding]; other site 862719008783 G-X-G motif; other site 862719008784 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 862719008785 Ligand Binding Site [chemical binding]; other site 862719008786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719008787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 862719008788 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 862719008789 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 862719008790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719008791 motif II; other site 862719008792 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 862719008793 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 862719008794 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 862719008795 dimer interface [polypeptide binding]; other site 862719008796 active site 862719008797 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862719008798 catalytic residues [active] 862719008799 substrate binding site [chemical binding]; other site 862719008800 MgtC family; Region: MgtC; pfam02308 862719008801 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 862719008802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719008803 putative substrate translocation pore; other site 862719008804 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 862719008805 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 862719008806 active site 862719008807 Riboflavin kinase; Region: Flavokinase; pfam01687 862719008808 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 862719008809 dimer interaction site [polypeptide binding]; other site 862719008810 substrate-binding tunnel; other site 862719008811 active site 862719008812 catalytic site [active] 862719008813 substrate binding site [chemical binding]; other site 862719008814 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 862719008815 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 862719008816 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 862719008817 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862719008818 TAP-like protein; Region: Abhydrolase_4; pfam08386 862719008819 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 862719008820 Domain of unknown function DUF20; Region: UPF0118; pfam01594 862719008821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 862719008822 CreA protein; Region: CreA; pfam05981 862719008823 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 862719008824 active site 862719008825 Zn binding site [ion binding]; other site 862719008826 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 862719008827 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 862719008828 NRDE protein; Region: NRDE; cl01315 862719008829 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 862719008830 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 862719008831 ATP binding site [chemical binding]; other site 862719008832 active site 862719008833 substrate binding site [chemical binding]; other site 862719008834 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 862719008835 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 862719008836 endonuclease III; Region: ENDO3c; smart00478 862719008837 minor groove reading motif; other site 862719008838 helix-hairpin-helix signature motif; other site 862719008839 substrate binding pocket [chemical binding]; other site 862719008840 active site 862719008841 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 862719008842 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 862719008843 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 862719008844 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719008845 putative active site [active] 862719008846 putative metal binding site [ion binding]; other site 862719008847 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719008848 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 862719008849 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 862719008850 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 862719008851 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 862719008852 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 862719008853 putative active site [active] 862719008854 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 862719008855 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 862719008856 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719008857 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 862719008858 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 862719008859 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 862719008860 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 862719008861 putative acyl-acceptor binding pocket; other site 862719008862 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 862719008863 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 862719008864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008865 active site 862719008866 phosphorylation site [posttranslational modification] 862719008867 intermolecular recognition site; other site 862719008868 dimerization interface [polypeptide binding]; other site 862719008869 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719008870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719008871 dimer interface [polypeptide binding]; other site 862719008872 phosphorylation site [posttranslational modification] 862719008873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719008874 ATP binding site [chemical binding]; other site 862719008875 Mg2+ binding site [ion binding]; other site 862719008876 G-X-G motif; other site 862719008877 Response regulator receiver domain; Region: Response_reg; pfam00072 862719008878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008879 active site 862719008880 phosphorylation site [posttranslational modification] 862719008881 intermolecular recognition site; other site 862719008882 dimerization interface [polypeptide binding]; other site 862719008883 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719008884 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 862719008885 Ligand binding site [chemical binding]; other site 862719008886 Electron transfer flavoprotein domain; Region: ETF; pfam01012 862719008887 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 862719008888 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 862719008889 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 862719008890 oxidoreductase; Provisional; Region: PRK10015 862719008891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862719008892 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 862719008893 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719008894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008895 active site 862719008896 phosphorylation site [posttranslational modification] 862719008897 intermolecular recognition site; other site 862719008898 dimerization interface [polypeptide binding]; other site 862719008899 Nitrogen fixation protein NifW; Region: NifW; pfam03206 862719008900 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 862719008901 serine O-acetyltransferase; Region: cysE; TIGR01172 862719008902 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 862719008903 trimer interface [polypeptide binding]; other site 862719008904 active site 862719008905 substrate binding site [chemical binding]; other site 862719008906 CoA binding site [chemical binding]; other site 862719008907 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 862719008908 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 862719008909 active site 862719008910 catalytic residues [active] 862719008911 metal binding site [ion binding]; metal-binding site 862719008912 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 862719008913 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 862719008914 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719008915 catalytic residue [active] 862719008916 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 862719008917 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 862719008918 trimerization site [polypeptide binding]; other site 862719008919 active site 862719008920 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 862719008921 NifU-like domain; Region: NifU; pfam01106 862719008922 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 862719008923 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 862719008924 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 862719008925 FMN binding site [chemical binding]; other site 862719008926 active site 862719008927 substrate binding site [chemical binding]; other site 862719008928 catalytic residue [active] 862719008929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719008930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719008931 Predicted permeases [General function prediction only]; Region: RarD; COG2962 862719008932 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 862719008933 putative GSH binding site [chemical binding]; other site 862719008934 catalytic residues [active] 862719008935 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 862719008936 adenylosuccinate lyase; Provisional; Region: PRK07492 862719008937 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 862719008938 tetramer interface [polypeptide binding]; other site 862719008939 active site 862719008940 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719008941 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719008942 PAS domain S-box; Region: sensory_box; TIGR00229 862719008943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719008944 PAS domain; Region: PAS_9; pfam13426 862719008945 putative active site [active] 862719008946 heme pocket [chemical binding]; other site 862719008947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719008948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719008949 metal binding site [ion binding]; metal-binding site 862719008950 active site 862719008951 I-site; other site 862719008952 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719008953 Protein of unknown function DUF45; Region: DUF45; pfam01863 862719008954 PAS domain; Region: PAS; smart00091 862719008955 PAS fold; Region: PAS_4; pfam08448 862719008956 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719008957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719008958 dimer interface [polypeptide binding]; other site 862719008959 phosphorylation site [posttranslational modification] 862719008960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719008961 ATP binding site [chemical binding]; other site 862719008962 Mg2+ binding site [ion binding]; other site 862719008963 G-X-G motif; other site 862719008964 Response regulator receiver domain; Region: Response_reg; pfam00072 862719008965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719008966 active site 862719008967 phosphorylation site [posttranslational modification] 862719008968 intermolecular recognition site; other site 862719008969 dimerization interface [polypeptide binding]; other site 862719008970 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 862719008971 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 862719008972 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 862719008973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719008974 putative PBP binding loops; other site 862719008975 dimer interface [polypeptide binding]; other site 862719008976 ABC-ATPase subunit interface; other site 862719008977 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 862719008978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719008979 dimer interface [polypeptide binding]; other site 862719008980 conserved gate region; other site 862719008981 putative PBP binding loops; other site 862719008982 ABC-ATPase subunit interface; other site 862719008983 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 862719008984 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 862719008985 Walker A/P-loop; other site 862719008986 ATP binding site [chemical binding]; other site 862719008987 Q-loop/lid; other site 862719008988 ABC transporter signature motif; other site 862719008989 Walker B; other site 862719008990 D-loop; other site 862719008991 H-loop/switch region; other site 862719008992 TOBE domain; Region: TOBE_2; pfam08402 862719008993 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 862719008994 heat shock protein HtpX; Provisional; Region: PRK01345 862719008995 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 862719008996 CobD/Cbib protein; Region: CobD_Cbib; cl00561 862719008997 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862719008998 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 862719008999 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862719009000 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 862719009001 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719009002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009003 active site 862719009004 phosphorylation site [posttranslational modification] 862719009005 intermolecular recognition site; other site 862719009006 dimerization interface [polypeptide binding]; other site 862719009007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719009008 dimer interface [polypeptide binding]; other site 862719009009 phosphorylation site [posttranslational modification] 862719009010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009011 ATP binding site [chemical binding]; other site 862719009012 Mg2+ binding site [ion binding]; other site 862719009013 G-X-G motif; other site 862719009014 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719009015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009016 active site 862719009017 phosphorylation site [posttranslational modification] 862719009018 intermolecular recognition site; other site 862719009019 dimerization interface [polypeptide binding]; other site 862719009020 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719009021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719009022 dimerization interface [polypeptide binding]; other site 862719009023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719009024 PAS fold; Region: PAS_3; pfam08447 862719009025 putative active site [active] 862719009026 heme pocket [chemical binding]; other site 862719009027 PAS domain; Region: PAS; smart00091 862719009028 PAS fold; Region: PAS_7; pfam12860 862719009029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719009030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719009031 dimer interface [polypeptide binding]; other site 862719009032 phosphorylation site [posttranslational modification] 862719009033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009034 ATP binding site [chemical binding]; other site 862719009035 Mg2+ binding site [ion binding]; other site 862719009036 G-X-G motif; other site 862719009037 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 862719009038 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 862719009039 anti sigma factor interaction site; other site 862719009040 regulatory phosphorylation site [posttranslational modification]; other site 862719009041 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 862719009042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 862719009043 Response regulator receiver domain; Region: Response_reg; pfam00072 862719009044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009045 active site 862719009046 phosphorylation site [posttranslational modification] 862719009047 intermolecular recognition site; other site 862719009048 dimerization interface [polypeptide binding]; other site 862719009049 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 862719009050 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 862719009051 ATP-NAD kinase; Region: NAD_kinase; pfam01513 862719009052 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 862719009053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719009054 Walker A motif; other site 862719009055 ATP binding site [chemical binding]; other site 862719009056 Walker B motif; other site 862719009057 arginine finger; other site 862719009058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719009059 Walker A motif; other site 862719009060 ATP binding site [chemical binding]; other site 862719009061 Walker B motif; other site 862719009062 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 862719009063 Uncharacterized conserved protein [Function unknown]; Region: COG2127 862719009064 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719009065 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719009066 Phasin protein; Region: Phasin_2; pfam09361 862719009067 Phasin protein; Region: Phasin_2; pfam09361 862719009068 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 862719009069 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 862719009070 active site 862719009071 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 862719009072 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 862719009073 Sporulation related domain; Region: SPOR; pfam05036 862719009074 Response regulator receiver domain; Region: Response_reg; pfam00072 862719009075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009076 active site 862719009077 phosphorylation site [posttranslational modification] 862719009078 intermolecular recognition site; other site 862719009079 dimerization interface [polypeptide binding]; other site 862719009080 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 862719009081 PAS fold; Region: PAS_7; pfam12860 862719009082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719009083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719009084 dimer interface [polypeptide binding]; other site 862719009085 phosphorylation site [posttranslational modification] 862719009086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009087 ATP binding site [chemical binding]; other site 862719009088 Mg2+ binding site [ion binding]; other site 862719009089 G-X-G motif; other site 862719009090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719009091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719009092 dimer interface [polypeptide binding]; other site 862719009093 phosphorylation site [posttranslational modification] 862719009094 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 862719009095 Response regulator receiver domain; Region: Response_reg; pfam00072 862719009096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009097 active site 862719009098 phosphorylation site [posttranslational modification] 862719009099 intermolecular recognition site; other site 862719009100 dimerization interface [polypeptide binding]; other site 862719009101 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 862719009102 PAS fold; Region: PAS_4; pfam08448 862719009103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719009104 putative active site [active] 862719009105 heme pocket [chemical binding]; other site 862719009106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719009107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719009108 dimer interface [polypeptide binding]; other site 862719009109 phosphorylation site [posttranslational modification] 862719009110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009111 ATP binding site [chemical binding]; other site 862719009112 Mg2+ binding site [ion binding]; other site 862719009113 G-X-G motif; other site 862719009114 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 862719009115 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 862719009116 dimer interaction site [polypeptide binding]; other site 862719009117 substrate-binding tunnel; other site 862719009118 active site 862719009119 catalytic site [active] 862719009120 substrate binding site [chemical binding]; other site 862719009121 phosphate acetyltransferase; Provisional; Region: PRK11890 862719009122 Acetokinase family; Region: Acetate_kinase; cl17229 862719009123 propionate/acetate kinase; Provisional; Region: PRK12379 862719009124 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719009125 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 862719009126 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 862719009127 active site 862719009128 dimer interface [polypeptide binding]; other site 862719009129 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 862719009130 dimer interface [polypeptide binding]; other site 862719009131 active site 862719009132 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 862719009133 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 862719009134 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 862719009135 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 862719009136 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 862719009137 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 862719009138 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 862719009139 lipoprotein signal peptidase; Provisional; Region: PRK14787 862719009140 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 862719009141 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719009142 active site 862719009143 HIGH motif; other site 862719009144 nucleotide binding site [chemical binding]; other site 862719009145 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 862719009146 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 862719009147 active site 862719009148 KMSKS motif; other site 862719009149 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 862719009150 tRNA binding surface [nucleotide binding]; other site 862719009151 anticodon binding site; other site 862719009152 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 862719009153 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 862719009154 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719009155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719009156 TPR motif; other site 862719009157 binding surface 862719009158 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719009159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719009160 binding surface 862719009161 TPR motif; other site 862719009162 TPR repeat; Region: TPR_11; pfam13414 862719009163 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719009164 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719009165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719009166 active site 862719009167 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 862719009168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719009169 active site 862719009170 Hemerythrin; Region: Hemerythrin; cd12107 862719009171 Fe binding site [ion binding]; other site 862719009172 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862719009173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719009174 dimerization interface [polypeptide binding]; other site 862719009175 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009176 dimer interface [polypeptide binding]; other site 862719009177 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719009178 putative CheW interface [polypeptide binding]; other site 862719009179 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 862719009180 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719009181 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 862719009182 homotrimer interaction site [polypeptide binding]; other site 862719009183 putative active site [active] 862719009184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 862719009185 Protein of unknown function, DUF482; Region: DUF482; pfam04339 862719009186 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 862719009187 CoA-transferase family III; Region: CoA_transf_3; pfam02515 862719009188 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 862719009189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719009190 FeS/SAM binding site; other site 862719009191 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 862719009192 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 862719009193 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 862719009194 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 862719009195 PBP superfamily domain; Region: PBP_like_2; pfam12849 862719009196 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 862719009197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719009198 dimer interface [polypeptide binding]; other site 862719009199 conserved gate region; other site 862719009200 putative PBP binding loops; other site 862719009201 ABC-ATPase subunit interface; other site 862719009202 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 862719009203 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 862719009204 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 862719009205 GTP binding site; other site 862719009206 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 862719009207 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 862719009208 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 862719009209 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 862719009210 [4Fe-4S] binding site [ion binding]; other site 862719009211 molybdopterin cofactor binding site; other site 862719009212 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 862719009213 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 862719009214 molybdopterin cofactor binding site; other site 862719009215 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 862719009216 4Fe-4S binding domain; Region: Fer4; cl02805 862719009217 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 862719009218 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 862719009219 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 862719009220 intersubunit interface [polypeptide binding]; other site 862719009221 active site 862719009222 Zn2+ binding site [ion binding]; other site 862719009223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719009224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719009225 dimer interface [polypeptide binding]; other site 862719009226 phosphorylation site [posttranslational modification] 862719009227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009228 ATP binding site [chemical binding]; other site 862719009229 Mg2+ binding site [ion binding]; other site 862719009230 G-X-G motif; other site 862719009231 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 862719009232 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 862719009233 putative active site [active] 862719009234 metal binding site [ion binding]; metal-binding site 862719009235 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 862719009236 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 862719009237 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 862719009238 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 862719009239 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 862719009240 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 862719009241 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719009242 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 862719009243 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 862719009244 Cu(I) binding site [ion binding]; other site 862719009245 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719009246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719009247 dimerization interface [polypeptide binding]; other site 862719009248 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009249 dimer interface [polypeptide binding]; other site 862719009250 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719009251 putative CheW interface [polypeptide binding]; other site 862719009252 Hemerythrin; Region: Hemerythrin; cd12107 862719009253 Fe binding site [ion binding]; other site 862719009254 PhoH-like protein; Region: PhoH; pfam02562 862719009255 DEAD-like helicases superfamily; Region: DEXDc; smart00487 862719009256 septum formation inhibitor; Reviewed; Region: minC; PRK00339 862719009257 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 862719009258 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 862719009259 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 862719009260 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 862719009261 P-loop; other site 862719009262 ADP binding residues [chemical binding]; other site 862719009263 Switch I; other site 862719009264 Switch II; other site 862719009265 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 862719009266 Family description; Region: VCBS; pfam13517 862719009267 Family description; Region: VCBS; pfam13517 862719009268 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 862719009269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719009270 PAS fold; Region: PAS_3; pfam08447 862719009271 putative active site [active] 862719009272 heme pocket [chemical binding]; other site 862719009273 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719009274 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009275 dimer interface [polypeptide binding]; other site 862719009276 putative CheW interface [polypeptide binding]; other site 862719009277 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009278 putative CheW interface [polypeptide binding]; other site 862719009279 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 862719009280 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 862719009281 active site 862719009282 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 862719009283 aromatic arch; other site 862719009284 DCoH dimer interaction site [polypeptide binding]; other site 862719009285 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 862719009286 DCoH tetramer interaction site [polypeptide binding]; other site 862719009287 substrate binding site [chemical binding]; other site 862719009288 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 862719009289 active site 862719009290 Predicted methyltransferase [General function prediction only]; Region: COG3897 862719009291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719009292 S-adenosylmethionine binding site [chemical binding]; other site 862719009293 CHAP domain; Region: CHAP; cl17642 862719009294 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 862719009295 UbiA prenyltransferase family; Region: UbiA; pfam01040 862719009296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009297 Response regulator receiver domain; Region: Response_reg; pfam00072 862719009298 active site 862719009299 phosphorylation site [posttranslational modification] 862719009300 intermolecular recognition site; other site 862719009301 dimerization interface [polypeptide binding]; other site 862719009302 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 862719009303 RNA methyltransferase, RsmE family; Region: TIGR00046 862719009304 glutamate--cysteine ligase; Region: PLN02611 862719009305 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 862719009306 4Fe-4S binding domain; Region: Fer4; cl02805 862719009307 Rop-like; Region: Rop-like; pfam05082 862719009308 probable nitrogen fixation protein; Region: TIGR02935 862719009309 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 862719009310 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 862719009311 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 862719009312 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 862719009313 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 862719009314 Cache domain; Region: Cache_1; pfam02743 862719009315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719009316 dimerization interface [polypeptide binding]; other site 862719009317 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009318 dimer interface [polypeptide binding]; other site 862719009319 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719009320 putative CheW interface [polypeptide binding]; other site 862719009321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719009322 PAS domain; Region: PAS_9; pfam13426 862719009323 putative active site [active] 862719009324 heme pocket [chemical binding]; other site 862719009325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719009326 PAS domain; Region: PAS_9; pfam13426 862719009327 putative active site [active] 862719009328 heme pocket [chemical binding]; other site 862719009329 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009330 dimer interface [polypeptide binding]; other site 862719009331 putative CheW interface [polypeptide binding]; other site 862719009332 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 862719009333 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 862719009334 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 862719009335 MoFe protein beta/alpha subunit interactions; other site 862719009336 Beta subunit P cluster binding residues; other site 862719009337 MoFe protein beta subunit/Fe protein contacts; other site 862719009338 MoFe protein dimer/ dimer interactions; other site 862719009339 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 862719009340 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 862719009341 MoFe protein alpha/beta subunit interactions; other site 862719009342 Alpha subunit P cluster binding residues; other site 862719009343 FeMoco binding residues [chemical binding]; other site 862719009344 MoFe protein alpha subunit/Fe protein contacts; other site 862719009345 MoFe protein dimer/ dimer interactions; other site 862719009346 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 862719009347 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 862719009348 Nucleotide-binding sites [chemical binding]; other site 862719009349 Walker A motif; other site 862719009350 Switch I region of nucleotide binding site; other site 862719009351 Fe4S4 binding sites [ion binding]; other site 862719009352 Switch II region of nucleotide binding site; other site 862719009353 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 862719009354 ADP-ribosyl-[dinitrogen reductase] hydrolase; Region: dinitro_DRAG; TIGR02662 862719009355 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 862719009356 ArsC family; Region: ArsC; pfam03960 862719009357 putative catalytic residues [active] 862719009358 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 862719009359 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 862719009360 putative active site [active] 862719009361 putative dimer interface [polypeptide binding]; other site 862719009362 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 862719009363 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 862719009364 AMP nucleosidase; Provisional; Region: PRK08292 862719009365 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 862719009366 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 862719009367 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 862719009368 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 862719009369 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 862719009370 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 862719009371 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719009372 FeS/SAM binding site; other site 862719009373 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 862719009374 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 862719009375 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 862719009376 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 862719009377 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 862719009378 GtrA-like protein; Region: GtrA; pfam04138 862719009379 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 862719009380 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 862719009381 Ligand binding site; other site 862719009382 Putative Catalytic site; other site 862719009383 DXD motif; other site 862719009384 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 862719009385 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 862719009386 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 862719009387 substrate binding site [chemical binding]; other site 862719009388 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 862719009389 tartrate dehydrogenase; Region: TTC; TIGR02089 862719009390 General stress protein [General function prediction only]; Region: GsiB; COG3729 862719009391 Response regulator receiver domain; Region: Response_reg; pfam00072 862719009392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009393 active site 862719009394 phosphorylation site [posttranslational modification] 862719009395 intermolecular recognition site; other site 862719009396 dimerization interface [polypeptide binding]; other site 862719009397 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 862719009398 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 862719009399 pyridoxamine kinase; Validated; Region: PRK05756 862719009400 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 862719009401 dimer interface [polypeptide binding]; other site 862719009402 pyridoxal binding site [chemical binding]; other site 862719009403 ATP binding site [chemical binding]; other site 862719009404 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719009405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719009406 putative active site [active] 862719009407 heme pocket [chemical binding]; other site 862719009408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719009409 dimer interface [polypeptide binding]; other site 862719009410 phosphorylation site [posttranslational modification] 862719009411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009412 ATP binding site [chemical binding]; other site 862719009413 Mg2+ binding site [ion binding]; other site 862719009414 G-X-G motif; other site 862719009415 Predicted ATPase [General function prediction only]; Region: COG1485 862719009416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 862719009417 non-specific DNA binding site [nucleotide binding]; other site 862719009418 salt bridge; other site 862719009419 sequence-specific DNA binding site [nucleotide binding]; other site 862719009420 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719009421 Winged helix-turn helix; Region: HTH_29; pfam13551 862719009422 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719009423 Homeodomain-like domain; Region: HTH_32; pfam13565 862719009424 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719009425 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719009426 ligand binding site [chemical binding]; other site 862719009427 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 862719009428 Tubulin like; Region: Tubulin_2; pfam13809 862719009429 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719009430 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719009431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 862719009432 Transposase; Region: DDE_Tnp_ISL3; pfam01610 862719009433 Transposase; Region: DDE_Tnp_ISL3; pfam01610 862719009434 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719009435 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862719009436 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719009437 dimerization interface [polypeptide binding]; other site 862719009438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009439 dimer interface [polypeptide binding]; other site 862719009440 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719009441 putative CheW interface [polypeptide binding]; other site 862719009442 lipoyl synthase; Provisional; Region: PRK05481 862719009443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719009444 FeS/SAM binding site; other site 862719009445 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 862719009446 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 862719009447 putative NAD(P) binding site [chemical binding]; other site 862719009448 catalytic Zn binding site [ion binding]; other site 862719009449 acetoin reductases; Region: 23BDH; TIGR02415 862719009450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719009451 NAD(P) binding site [chemical binding]; other site 862719009452 active site 862719009453 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 862719009454 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862719009455 E3 interaction surface; other site 862719009456 lipoyl attachment site [posttranslational modification]; other site 862719009457 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862719009458 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 862719009459 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 862719009460 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 862719009461 alpha subunit interface [polypeptide binding]; other site 862719009462 TPP binding site [chemical binding]; other site 862719009463 heterodimer interface [polypeptide binding]; other site 862719009464 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719009465 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 862719009466 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 862719009467 tetramer interface [polypeptide binding]; other site 862719009468 TPP-binding site [chemical binding]; other site 862719009469 heterodimer interface [polypeptide binding]; other site 862719009470 phosphorylation loop region [posttranslational modification] 862719009471 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 862719009472 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 862719009473 FAD binding domain; Region: FAD_binding_4; pfam01565 862719009474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 862719009475 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 862719009476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719009477 Walker A/P-loop; other site 862719009478 ATP binding site [chemical binding]; other site 862719009479 Q-loop/lid; other site 862719009480 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862719009481 ABC transporter; Region: ABC_tran_2; pfam12848 862719009482 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862719009483 Cupin domain; Region: Cupin_2; pfam07883 862719009484 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 862719009485 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009486 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719009487 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009488 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009489 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009490 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009491 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 862719009492 VacJ like lipoprotein; Region: VacJ; cl01073 862719009493 Predicted transcriptional regulator [Transcription]; Region: COG2345 862719009494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719009495 putative DNA binding site [nucleotide binding]; other site 862719009496 putative Zn2+ binding site [ion binding]; other site 862719009497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719009498 S-adenosylmethionine binding site [chemical binding]; other site 862719009499 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 862719009500 FAD binding site [chemical binding]; other site 862719009501 Domain of unknown function DUF29; Region: DUF29; pfam01724 862719009502 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 862719009503 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 862719009504 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 862719009505 substrate binding pocket [chemical binding]; other site 862719009506 dimer interface [polypeptide binding]; other site 862719009507 inhibitor binding site; inhibition site 862719009508 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 862719009509 B12 binding site [chemical binding]; other site 862719009510 cobalt ligand [ion binding]; other site 862719009511 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 862719009512 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 862719009513 active site 862719009514 NTP binding site [chemical binding]; other site 862719009515 metal binding triad [ion binding]; metal-binding site 862719009516 antibiotic binding site [chemical binding]; other site 862719009517 HEPN domain; Region: HEPN; pfam05168 862719009518 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862719009519 active site 862719009520 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009521 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 862719009522 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009523 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009524 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719009525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719009526 metal binding site [ion binding]; metal-binding site 862719009527 active site 862719009528 I-site; other site 862719009529 Nitronate monooxygenase; Region: NMO; pfam03060 862719009530 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 862719009531 FMN binding site [chemical binding]; other site 862719009532 substrate binding site [chemical binding]; other site 862719009533 putative catalytic residue [active] 862719009534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719009535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719009536 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 862719009537 peptide binding site [polypeptide binding]; other site 862719009538 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 862719009539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719009540 non-specific DNA binding site [nucleotide binding]; other site 862719009541 salt bridge; other site 862719009542 sequence-specific DNA binding site [nucleotide binding]; other site 862719009543 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 862719009544 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 862719009545 CysD dimerization site [polypeptide binding]; other site 862719009546 G1 box; other site 862719009547 putative GEF interaction site [polypeptide binding]; other site 862719009548 GTP/Mg2+ binding site [chemical binding]; other site 862719009549 Switch I region; other site 862719009550 G2 box; other site 862719009551 G3 box; other site 862719009552 Switch II region; other site 862719009553 G4 box; other site 862719009554 G5 box; other site 862719009555 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 862719009556 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 862719009557 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 862719009558 ligand-binding site [chemical binding]; other site 862719009559 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 862719009560 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 862719009561 Active Sites [active] 862719009562 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 862719009563 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 862719009564 Active Sites [active] 862719009565 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 862719009566 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 862719009567 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 862719009568 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 862719009569 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 862719009570 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 862719009571 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 862719009572 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719009573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 862719009574 Peptidase M15; Region: Peptidase_M15_3; cl01194 862719009575 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719009576 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009577 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719009578 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009579 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009580 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009581 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719009582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719009583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719009584 dimer interface [polypeptide binding]; other site 862719009585 phosphorylation site [posttranslational modification] 862719009586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009587 ATP binding site [chemical binding]; other site 862719009588 Mg2+ binding site [ion binding]; other site 862719009589 G-X-G motif; other site 862719009590 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 862719009591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719009592 active site 862719009593 phosphorylation site [posttranslational modification] 862719009594 intermolecular recognition site; other site 862719009595 dimerization interface [polypeptide binding]; other site 862719009596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719009597 DNA binding residues [nucleotide binding] 862719009598 dimerization interface [polypeptide binding]; other site 862719009599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719009600 putative active site [active] 862719009601 heme pocket [chemical binding]; other site 862719009602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719009603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719009604 dimer interface [polypeptide binding]; other site 862719009605 phosphorylation site [posttranslational modification] 862719009606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719009607 ATP binding site [chemical binding]; other site 862719009608 Mg2+ binding site [ion binding]; other site 862719009609 G-X-G motif; other site 862719009610 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719009611 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 862719009612 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 862719009613 DctM-like transporters; Region: DctM; pfam06808 862719009614 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 862719009615 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 862719009616 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 862719009617 putative [4Fe-4S] binding site [ion binding]; other site 862719009618 putative molybdopterin cofactor binding site [chemical binding]; other site 862719009619 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 862719009620 molybdopterin cofactor binding site; other site 862719009621 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 862719009622 DHH family; Region: DHH; pfam01368 862719009623 DHHA1 domain; Region: DHHA1; pfam02272 862719009624 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 862719009625 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 862719009626 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 862719009627 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 862719009628 FMN binding site [chemical binding]; other site 862719009629 active site 862719009630 catalytic residues [active] 862719009631 substrate binding site [chemical binding]; other site 862719009632 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 862719009633 dimerization interface [polypeptide binding]; other site 862719009634 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719009635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009636 dimer interface [polypeptide binding]; other site 862719009637 putative CheW interface [polypeptide binding]; other site 862719009638 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 862719009639 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 862719009640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719009641 catalytic residue [active] 862719009642 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 862719009643 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 862719009644 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 862719009645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 862719009646 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 862719009647 hypothetical protein; Validated; Region: PRK09039 862719009648 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719009649 ligand binding site [chemical binding]; other site 862719009650 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 862719009651 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 862719009652 active site 862719009653 dimerization interface [polypeptide binding]; other site 862719009654 elongation factor P; Validated; Region: PRK00529 862719009655 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 862719009656 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 862719009657 RNA binding site [nucleotide binding]; other site 862719009658 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 862719009659 RNA binding site [nucleotide binding]; other site 862719009660 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 862719009661 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 862719009662 motif 1; other site 862719009663 dimer interface [polypeptide binding]; other site 862719009664 active site 862719009665 motif 2; other site 862719009666 motif 3; other site 862719009667 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 862719009668 hypothetical protein; Provisional; Region: PRK10621 862719009669 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862719009670 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 862719009671 thiamine phosphate binding site [chemical binding]; other site 862719009672 active site 862719009673 pyrophosphate binding site [ion binding]; other site 862719009674 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 862719009675 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 862719009676 putative active site; other site 862719009677 catalytic residue [active] 862719009678 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 862719009679 HicB family; Region: HicB; pfam05534 862719009680 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719009681 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719009682 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009683 dimer interface [polypeptide binding]; other site 862719009684 putative CheW interface [polypeptide binding]; other site 862719009685 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 862719009686 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 862719009687 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 862719009688 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 862719009689 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 862719009690 TPP-binding site [chemical binding]; other site 862719009691 dimer interface [polypeptide binding]; other site 862719009692 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862719009693 PYR/PP interface [polypeptide binding]; other site 862719009694 dimer interface [polypeptide binding]; other site 862719009695 TPP binding site [chemical binding]; other site 862719009696 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719009697 Cell division protein ZapA; Region: ZapA; pfam05164 862719009698 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 862719009699 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 862719009700 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719009701 putative active site [active] 862719009702 metal binding site [ion binding]; metal-binding site 862719009703 homodimer binding site [polypeptide binding]; other site 862719009704 hypothetical protein; Validated; Region: PRK00110 862719009705 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 862719009706 active site 862719009707 putative DNA-binding cleft [nucleotide binding]; other site 862719009708 dimer interface [polypeptide binding]; other site 862719009709 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 862719009710 putative active site [active] 862719009711 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 862719009712 RuvA N terminal domain; Region: RuvA_N; pfam01330 862719009713 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 862719009714 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 862719009715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719009716 Walker A motif; other site 862719009717 ATP binding site [chemical binding]; other site 862719009718 Walker B motif; other site 862719009719 arginine finger; other site 862719009720 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 862719009721 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862719009722 active site 862719009723 TolQ protein; Region: tolQ; TIGR02796 862719009724 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 862719009725 TolR protein; Region: tolR; TIGR02801 862719009726 translocation protein TolB; Provisional; Region: tolB; PRK05137 862719009727 TolB amino-terminal domain; Region: TolB_N; pfam04052 862719009728 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 862719009729 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 862719009730 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 862719009731 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 862719009732 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719009733 ligand binding site [chemical binding]; other site 862719009734 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 862719009735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719009736 binding surface 862719009737 TPR motif; other site 862719009738 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 862719009739 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 862719009740 Ligand Binding Site [chemical binding]; other site 862719009741 FtsH Extracellular; Region: FtsH_ext; pfam06480 862719009742 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 862719009743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719009744 Walker A motif; other site 862719009745 ATP binding site [chemical binding]; other site 862719009746 Walker B motif; other site 862719009747 arginine finger; other site 862719009748 Peptidase family M41; Region: Peptidase_M41; pfam01434 862719009749 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 862719009750 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 862719009751 NAD binding site [chemical binding]; other site 862719009752 homotetramer interface [polypeptide binding]; other site 862719009753 homodimer interface [polypeptide binding]; other site 862719009754 substrate binding site [chemical binding]; other site 862719009755 active site 862719009756 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 862719009757 Protein of unknown function (DUF805); Region: DUF805; pfam05656 862719009758 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 862719009759 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 862719009760 HSP70 interaction site [polypeptide binding]; other site 862719009761 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 862719009762 substrate binding site [polypeptide binding]; other site 862719009763 dimer interface [polypeptide binding]; other site 862719009764 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 862719009765 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 862719009766 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 862719009767 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 862719009768 Cation efflux family; Region: Cation_efflux; cl00316 862719009769 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 862719009770 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719009771 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719009772 dimer interface [polypeptide binding]; other site 862719009773 putative CheW interface [polypeptide binding]; other site 862719009774 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 862719009775 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 862719009776 transmembrane helices; other site 862719009777 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 862719009778 GAF domain; Region: GAF; pfam01590 862719009779 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 862719009780 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719009781 Zn2+ binding site [ion binding]; other site 862719009782 Mg2+ binding site [ion binding]; other site 862719009783 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 862719009784 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 862719009785 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719009786 Ligand Binding Site [chemical binding]; other site 862719009787 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719009788 Ligand Binding Site [chemical binding]; other site 862719009789 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 862719009790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719009791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 862719009792 Coenzyme A binding pocket [chemical binding]; other site 862719009793 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 862719009794 dimerization interface [polypeptide binding]; other site 862719009795 metal binding site [ion binding]; metal-binding site 862719009796 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 862719009797 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 862719009798 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 862719009799 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 862719009800 dimer interface [polypeptide binding]; other site 862719009801 active site 862719009802 glycine-pyridoxal phosphate binding site [chemical binding]; other site 862719009803 folate binding site [chemical binding]; other site 862719009804 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 862719009805 ATP cone domain; Region: ATP-cone; pfam03477 862719009806 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 862719009807 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 862719009808 thiamine monophosphate kinase; Provisional; Region: PRK05731 862719009809 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 862719009810 ATP binding site [chemical binding]; other site 862719009811 dimerization interface [polypeptide binding]; other site 862719009812 transcription antitermination factor NusB; Region: nusB; TIGR01951 862719009813 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 862719009814 homopentamer interface [polypeptide binding]; other site 862719009815 active site 862719009816 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 862719009817 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 862719009818 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 862719009819 dimerization interface [polypeptide binding]; other site 862719009820 active site 862719009821 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 862719009822 Lumazine binding domain; Region: Lum_binding; pfam00677 862719009823 Lumazine binding domain; Region: Lum_binding; pfam00677 862719009824 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 862719009825 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 862719009826 catalytic motif [active] 862719009827 Zn binding site [ion binding]; other site 862719009828 RibD C-terminal domain; Region: RibD_C; cl17279 862719009829 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 862719009830 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 862719009831 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 862719009832 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 862719009833 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 862719009834 putative phosphate acyltransferase; Provisional; Region: PRK05331 862719009835 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 862719009836 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 862719009837 dimer interface [polypeptide binding]; other site 862719009838 active site 862719009839 CoA binding pocket [chemical binding]; other site 862719009840 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862719009841 IHF dimer interface [polypeptide binding]; other site 862719009842 IHF - DNA interface [nucleotide binding]; other site 862719009843 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 862719009844 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 862719009845 DNA binding residues [nucleotide binding] 862719009846 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 862719009847 Evidence 7 : Gene remnant; Product type e : enzyme 862719009848 Evidence 4 : Homologs of previously reported genes of unknown function; Product type e : enzyme 862719009849 Evidence 7 : Gene remnant; Product type e : enzyme 862719009850 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 862719009851 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 862719009852 catalytic residues [active] 862719009853 catalytic nucleophile [active] 862719009854 Recombinase; Region: Recombinase; pfam07508 862719009855 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 862719009856 Helix-turn-helix domain; Region: HTH_17; pfam12728 862719009857 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719009858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 862719009859 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 862719009860 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 862719009861 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 862719009862 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 862719009863 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719009864 hypothetical protein; Provisional; Region: PRK07338 862719009865 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 862719009866 metal binding site [ion binding]; metal-binding site 862719009867 dimer interface [polypeptide binding]; other site 862719009868 hypothetical protein; Provisional; Region: PRK07079 862719009869 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 862719009870 metal binding site [ion binding]; metal-binding site 862719009871 putative dimer interface [polypeptide binding]; other site 862719009872 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 862719009873 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719009874 Walker A/P-loop; other site 862719009875 ATP binding site [chemical binding]; other site 862719009876 Q-loop/lid; other site 862719009877 ABC transporter signature motif; other site 862719009878 Walker B; other site 862719009879 D-loop; other site 862719009880 H-loop/switch region; other site 862719009881 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719009882 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 862719009883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719009884 Walker A/P-loop; other site 862719009885 ATP binding site [chemical binding]; other site 862719009886 Q-loop/lid; other site 862719009887 ABC transporter signature motif; other site 862719009888 Walker B; other site 862719009889 D-loop; other site 862719009890 H-loop/switch region; other site 862719009891 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 862719009892 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 862719009893 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 862719009894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719009895 dimer interface [polypeptide binding]; other site 862719009896 conserved gate region; other site 862719009897 putative PBP binding loops; other site 862719009898 ABC-ATPase subunit interface; other site 862719009899 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719009900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719009901 dimer interface [polypeptide binding]; other site 862719009902 conserved gate region; other site 862719009903 putative PBP binding loops; other site 862719009904 ABC-ATPase subunit interface; other site 862719009905 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 862719009906 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719009907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719009908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719009909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719009910 dimerization interface [polypeptide binding]; other site 862719009911 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 862719009912 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 862719009913 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719009914 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719009915 DNA binding residues [nucleotide binding] 862719009916 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 862719009917 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719009918 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 862719009919 Domain of unknown function (DUF305); Region: DUF305; cl17794 862719009920 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719009921 short chain dehydrogenase; Provisional; Region: PRK07577 862719009922 classical (c) SDRs; Region: SDR_c; cd05233 862719009923 NAD(P) binding site [chemical binding]; other site 862719009924 active site 862719009925 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 862719009926 putative catalytic residues [active] 862719009927 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719009928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719009929 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719009930 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719009931 putative effector binding pocket; other site 862719009932 dimerization interface [polypeptide binding]; other site 862719009933 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 862719009934 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 862719009935 classical (c) SDRs; Region: SDR_c; cd05233 862719009936 NAD(P) binding site [chemical binding]; other site 862719009937 active site 862719009938 Evidence 7 : Gene remnant; Product type e : enzyme 862719009939 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 862719009940 Transcriptional regulators [Transcription]; Region: MarR; COG1846 862719009941 MarR family; Region: MarR; pfam01047 862719009942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719009943 Coenzyme A binding pocket [chemical binding]; other site 862719009944 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719009945 HemK family putative methylases; Region: hemK_fam; TIGR00536 862719009946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719009947 S-adenosylmethionine binding site [chemical binding]; other site 862719009948 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 862719009949 ArsC family; Region: ArsC; pfam03960 862719009950 catalytic residues [active] 862719009951 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 862719009952 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 862719009953 ligand binding site [chemical binding]; other site 862719009954 NAD binding site [chemical binding]; other site 862719009955 tetramer interface [polypeptide binding]; other site 862719009956 catalytic site [active] 862719009957 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 862719009958 L-serine binding site [chemical binding]; other site 862719009959 ACT domain interface; other site 862719009960 HNH endonuclease; Region: HNH; pfam01844 862719009961 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719009962 EamA-like transporter family; Region: EamA; pfam00892 862719009963 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 862719009964 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 862719009965 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 862719009966 catalytic site [active] 862719009967 subunit interface [polypeptide binding]; other site 862719009968 Yqey-like protein; Region: YqeY; pfam09424 862719009969 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 862719009970 putative active site [active] 862719009971 DNA primase; Validated; Region: dnaG; PRK05667 862719009972 CHC2 zinc finger; Region: zf-CHC2; cl17510 862719009973 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 862719009974 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 862719009975 active site 862719009976 metal binding site [ion binding]; metal-binding site 862719009977 interdomain interaction site; other site 862719009978 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 862719009979 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 862719009980 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 862719009981 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 862719009982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719009983 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 862719009984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719009985 DNA binding residues [nucleotide binding] 862719009986 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 862719009987 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719009988 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719009989 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719009990 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 862719009991 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 862719009992 Walker A/P-loop; other site 862719009993 ATP binding site [chemical binding]; other site 862719009994 Q-loop/lid; other site 862719009995 ABC transporter signature motif; other site 862719009996 Walker B; other site 862719009997 D-loop; other site 862719009998 H-loop/switch region; other site 862719009999 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719010000 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719010001 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 862719010002 putative ADP-binding pocket [chemical binding]; other site 862719010003 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719010004 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 862719010005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719010006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719010007 DNA binding residues [nucleotide binding] 862719010008 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 862719010009 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862719010010 Predicted integral membrane protein [Function unknown]; Region: COG5637 862719010011 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 862719010012 hydrophobic ligand binding site; other site 862719010013 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 862719010014 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 862719010015 NAD binding site [chemical binding]; other site 862719010016 catalytic Zn binding site [ion binding]; other site 862719010017 structural Zn binding site [ion binding]; other site 862719010018 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 862719010019 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 862719010020 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 862719010021 catalytic site [active] 862719010022 active site 862719010023 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 862719010024 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 862719010025 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 862719010026 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 862719010027 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 862719010028 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 862719010029 NodB motif; other site 862719010030 active site 862719010031 catalytic site [active] 862719010032 metal binding site [ion binding]; metal-binding site 862719010033 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 862719010034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 862719010035 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 862719010036 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 862719010037 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 862719010038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 862719010039 Peptidase M15; Region: Peptidase_M15_3; cl01194 862719010040 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719010041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719010042 salt bridge; other site 862719010043 non-specific DNA binding site [nucleotide binding]; other site 862719010044 sequence-specific DNA binding site [nucleotide binding]; other site 862719010045 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 862719010046 G1 box; other site 862719010047 GTP/Mg2+ binding site [chemical binding]; other site 862719010048 G2 box; other site 862719010049 Switch I region; other site 862719010050 G3 box; other site 862719010051 Switch II region; other site 862719010052 G4 box; other site 862719010053 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719010054 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719010055 substrate binding pocket [chemical binding]; other site 862719010056 membrane-bound complex binding site; other site 862719010057 hinge residues; other site 862719010058 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 862719010059 Dehydroquinase class II; Region: DHquinase_II; pfam01220 862719010060 trimer interface [polypeptide binding]; other site 862719010061 active site 862719010062 dimer interface [polypeptide binding]; other site 862719010063 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 862719010064 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 862719010065 carboxyltransferase (CT) interaction site; other site 862719010066 biotinylation site [posttranslational modification]; other site 862719010067 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 862719010068 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719010069 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 862719010070 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 862719010071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719010072 PAS domain; Region: PAS_9; pfam13426 862719010073 putative active site [active] 862719010074 heme pocket [chemical binding]; other site 862719010075 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862719010076 Tar ligand binding domain homologue; Region: TarH; pfam02203 862719010077 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719010078 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719010079 dimer interface [polypeptide binding]; other site 862719010080 putative CheW interface [polypeptide binding]; other site 862719010081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719010082 PAS fold; Region: PAS_3; pfam08447 862719010083 putative active site [active] 862719010084 heme pocket [chemical binding]; other site 862719010085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719010086 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862719010087 putative active site [active] 862719010088 heme pocket [chemical binding]; other site 862719010089 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 862719010090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719010091 putative active site [active] 862719010092 heme pocket [chemical binding]; other site 862719010093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719010094 putative active site [active] 862719010095 heme pocket [chemical binding]; other site 862719010096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719010097 dimer interface [polypeptide binding]; other site 862719010098 phosphorylation site [posttranslational modification] 862719010099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719010100 ATP binding site [chemical binding]; other site 862719010101 Mg2+ binding site [ion binding]; other site 862719010102 G-X-G motif; other site 862719010103 CHASE domain; Region: CHASE; cl01369 862719010104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719010105 dimer interface [polypeptide binding]; other site 862719010106 phosphorylation site [posttranslational modification] 862719010107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719010108 ATP binding site [chemical binding]; other site 862719010109 Mg2+ binding site [ion binding]; other site 862719010110 G-X-G motif; other site 862719010111 Response regulator receiver domain; Region: Response_reg; pfam00072 862719010112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010113 active site 862719010114 phosphorylation site [posttranslational modification] 862719010115 intermolecular recognition site; other site 862719010116 dimerization interface [polypeptide binding]; other site 862719010117 Response regulator receiver domain; Region: Response_reg; pfam00072 862719010118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010119 active site 862719010120 phosphorylation site [posttranslational modification] 862719010121 intermolecular recognition site; other site 862719010122 PAS domain S-box; Region: sensory_box; TIGR00229 862719010123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719010124 putative active site [active] 862719010125 heme pocket [chemical binding]; other site 862719010126 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719010127 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719010128 metal binding site [ion binding]; metal-binding site 862719010129 active site 862719010130 I-site; other site 862719010131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010132 Response regulator receiver domain; Region: Response_reg; pfam00072 862719010133 active site 862719010134 phosphorylation site [posttranslational modification] 862719010135 intermolecular recognition site; other site 862719010136 dimerization interface [polypeptide binding]; other site 862719010137 Response regulator receiver domain; Region: Response_reg; pfam00072 862719010138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010139 active site 862719010140 phosphorylation site [posttranslational modification] 862719010141 intermolecular recognition site; other site 862719010142 dimerization interface [polypeptide binding]; other site 862719010143 NifQ; Region: NifQ; pfam04891 862719010144 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 862719010145 putative hydrophobic ligand binding site [chemical binding]; other site 862719010146 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 862719010147 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 862719010148 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862719010149 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719010150 protein binding site [polypeptide binding]; other site 862719010151 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719010152 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 862719010153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010154 active site 862719010155 phosphorylation site [posttranslational modification] 862719010156 intermolecular recognition site; other site 862719010157 dimerization interface [polypeptide binding]; other site 862719010158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719010159 DNA binding site [nucleotide binding] 862719010160 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 862719010161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719010162 dimerization interface [polypeptide binding]; other site 862719010163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719010164 dimer interface [polypeptide binding]; other site 862719010165 phosphorylation site [posttranslational modification] 862719010166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719010167 ATP binding site [chemical binding]; other site 862719010168 Mg2+ binding site [ion binding]; other site 862719010169 G-X-G motif; other site 862719010170 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 862719010171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719010172 putative substrate translocation pore; other site 862719010173 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 862719010174 active site 862719010175 multimer interface [polypeptide binding]; other site 862719010176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719010177 PAS domain; Region: PAS_9; pfam13426 862719010178 putative active site [active] 862719010179 heme pocket [chemical binding]; other site 862719010180 PAS fold; Region: PAS_7; pfam12860 862719010181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719010182 dimer interface [polypeptide binding]; other site 862719010183 phosphorylation site [posttranslational modification] 862719010184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719010185 ATP binding site [chemical binding]; other site 862719010186 G-X-G motif; other site 862719010187 Response regulator receiver domain; Region: Response_reg; pfam00072 862719010188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010189 active site 862719010190 phosphorylation site [posttranslational modification] 862719010191 intermolecular recognition site; other site 862719010192 dimerization interface [polypeptide binding]; other site 862719010193 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 862719010194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010195 active site 862719010196 phosphorylation site [posttranslational modification] 862719010197 intermolecular recognition site; other site 862719010198 dimerization interface [polypeptide binding]; other site 862719010199 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 862719010200 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719010201 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 862719010202 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719010203 active site 862719010204 ATP binding site [chemical binding]; other site 862719010205 substrate binding site [chemical binding]; other site 862719010206 activation loop (A-loop); other site 862719010207 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 862719010208 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 862719010209 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 862719010210 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 862719010211 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719010212 ligand binding site [chemical binding]; other site 862719010213 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 862719010214 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 862719010215 Sel1-like repeats; Region: SEL1; smart00671 862719010216 Sel1-like repeats; Region: SEL1; smart00671 862719010217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719010218 S-adenosylmethionine binding site [chemical binding]; other site 862719010219 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 862719010220 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 862719010221 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 862719010222 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 862719010223 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 862719010224 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 862719010225 ImpE protein; Region: ImpE; pfam07024 862719010226 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 862719010227 Protein of unknown function (DUF877); Region: DUF877; pfam05943 862719010228 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 862719010229 Protein of unknown function (DUF877); Region: DUF877; pfam05943 862719010230 Protein of unknown function (DUF770); Region: DUF770; pfam05591 862719010231 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 862719010232 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 862719010233 PAAR motif; Region: PAAR_motif; pfam05488 862719010234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719010235 S-adenosylmethionine binding site [chemical binding]; other site 862719010236 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 862719010237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719010238 Walker A motif; other site 862719010239 ATP binding site [chemical binding]; other site 862719010240 Walker B motif; other site 862719010241 arginine finger; other site 862719010242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719010243 Walker A motif; other site 862719010244 ATP binding site [chemical binding]; other site 862719010245 Walker B motif; other site 862719010246 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 862719010247 Protein of unknown function (DUF796); Region: DUF796; pfam05638 862719010248 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 862719010249 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 862719010250 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 862719010251 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 862719010252 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 862719010253 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862719010254 phosphopeptide binding site; other site 862719010255 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 862719010256 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 862719010257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719010258 putative substrate translocation pore; other site 862719010259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719010260 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 862719010261 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 862719010262 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 862719010263 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 862719010264 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 862719010265 anti sigma factor interaction site; other site 862719010266 regulatory phosphorylation site [posttranslational modification]; other site 862719010267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010268 Response regulator receiver domain; Region: Response_reg; pfam00072 862719010269 active site 862719010270 phosphorylation site [posttranslational modification] 862719010271 intermolecular recognition site; other site 862719010272 dimerization interface [polypeptide binding]; other site 862719010273 BON domain; Region: BON; pfam04972 862719010274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719010275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719010276 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 862719010277 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719010278 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719010279 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 862719010280 Protein export membrane protein; Region: SecD_SecF; cl14618 862719010281 anthranilate synthase component I; Provisional; Region: PRK13573 862719010282 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 862719010283 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 862719010284 SurA N-terminal domain; Region: SurA_N_3; cl07813 862719010285 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 862719010286 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 862719010287 CsbD-like; Region: CsbD; pfam05532 862719010288 hypothetical protein; Provisional; Region: PRK02237 862719010289 PAS fold; Region: PAS_4; pfam08448 862719010290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719010291 putative active site [active] 862719010292 heme pocket [chemical binding]; other site 862719010293 PAS domain S-box; Region: sensory_box; TIGR00229 862719010294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719010295 putative active site [active] 862719010296 heme pocket [chemical binding]; other site 862719010297 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719010298 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719010299 metal binding site [ion binding]; metal-binding site 862719010300 active site 862719010301 I-site; other site 862719010302 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719010303 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 862719010304 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 862719010305 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719010306 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 862719010307 Walker A/P-loop; other site 862719010308 ATP binding site [chemical binding]; other site 862719010309 Q-loop/lid; other site 862719010310 ABC transporter signature motif; other site 862719010311 Walker B; other site 862719010312 D-loop; other site 862719010313 H-loop/switch region; other site 862719010314 TOBE domain; Region: TOBE_2; pfam08402 862719010315 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 862719010316 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719010317 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 862719010318 Walker A/P-loop; other site 862719010319 ATP binding site [chemical binding]; other site 862719010320 Q-loop/lid; other site 862719010321 ABC transporter signature motif; other site 862719010322 Walker B; other site 862719010323 D-loop; other site 862719010324 H-loop/switch region; other site 862719010325 hypothetical protein; Provisional; Region: PRK10279 862719010326 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 862719010327 active site 862719010328 nucleophile elbow; other site 862719010329 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 862719010330 potassium/proton antiporter; Reviewed; Region: PRK05326 862719010331 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 862719010332 Transporter associated domain; Region: CorC_HlyC; smart01091 862719010333 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 862719010334 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 862719010335 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 862719010336 G1 box; other site 862719010337 putative GEF interaction site [polypeptide binding]; other site 862719010338 GTP/Mg2+ binding site [chemical binding]; other site 862719010339 Switch I region; other site 862719010340 G2 box; other site 862719010341 G3 box; other site 862719010342 Switch II region; other site 862719010343 G4 box; other site 862719010344 G5 box; other site 862719010345 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 862719010346 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 862719010347 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 862719010348 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862719010349 Surface antigen; Region: Bac_surface_Ag; pfam01103 862719010350 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 862719010351 Family of unknown function (DUF490); Region: DUF490; pfam04357 862719010352 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 862719010353 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 862719010354 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 862719010355 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719010356 catalytic residue [active] 862719010357 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719010358 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719010359 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719010360 dimer interface [polypeptide binding]; other site 862719010361 putative CheW interface [polypeptide binding]; other site 862719010362 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 862719010363 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 862719010364 catalytic site [active] 862719010365 G-X2-G-X-G-K; other site 862719010366 hypothetical protein; Provisional; Region: PRK11820 862719010367 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 862719010368 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 862719010369 short chain dehydrogenase; Provisional; Region: PRK07024 862719010370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010371 NAD(P) binding site [chemical binding]; other site 862719010372 active site 862719010373 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 862719010374 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 862719010375 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 862719010376 catalytic site [active] 862719010377 putative active site [active] 862719010378 putative substrate binding site [chemical binding]; other site 862719010379 HRDC domain; Region: HRDC; pfam00570 862719010380 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 862719010381 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 862719010382 dimer interface [polypeptide binding]; other site 862719010383 anticodon binding site; other site 862719010384 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 862719010385 homodimer interface [polypeptide binding]; other site 862719010386 motif 1; other site 862719010387 active site 862719010388 motif 2; other site 862719010389 GAD domain; Region: GAD; pfam02938 862719010390 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 862719010391 active site 862719010392 motif 3; other site 862719010393 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 862719010394 rRNA interaction site [nucleotide binding]; other site 862719010395 S8 interaction site; other site 862719010396 putative laminin-1 binding site; other site 862719010397 elongation factor Ts; Provisional; Region: tsf; PRK09377 862719010398 UBA/TS-N domain; Region: UBA; pfam00627 862719010399 Elongation factor TS; Region: EF_TS; pfam00889 862719010400 Elongation factor TS; Region: EF_TS; pfam00889 862719010401 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 862719010402 putative nucleotide binding site [chemical binding]; other site 862719010403 uridine monophosphate binding site [chemical binding]; other site 862719010404 homohexameric interface [polypeptide binding]; other site 862719010405 ribosome recycling factor; Reviewed; Region: frr; PRK00083 862719010406 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 862719010407 hinge region; other site 862719010408 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 862719010409 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 862719010410 catalytic residue [active] 862719010411 putative FPP diphosphate binding site; other site 862719010412 putative FPP binding hydrophobic cleft; other site 862719010413 dimer interface [polypeptide binding]; other site 862719010414 putative IPP diphosphate binding site; other site 862719010415 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 862719010416 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 862719010417 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 862719010418 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 862719010419 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 862719010420 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 862719010421 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 862719010422 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 862719010423 active site 862719010424 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 862719010425 protein binding site [polypeptide binding]; other site 862719010426 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 862719010427 putative substrate binding region [chemical binding]; other site 862719010428 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 862719010429 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862719010430 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862719010431 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862719010432 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 862719010433 Surface antigen; Region: Bac_surface_Ag; pfam01103 862719010434 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 862719010435 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 862719010436 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 862719010437 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 862719010438 active site 862719010439 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 862719010440 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 862719010441 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 862719010442 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719010443 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 862719010444 dimer interface [polypeptide binding]; other site 862719010445 active site 862719010446 metal binding site [ion binding]; metal-binding site 862719010447 glutathione binding site [chemical binding]; other site 862719010448 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 862719010449 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 862719010450 conserved cys residue [active] 862719010451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719010452 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719010453 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 862719010454 active site residue [active] 862719010455 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 862719010456 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 862719010457 dimer interface [polypeptide binding]; other site 862719010458 active site 862719010459 citrylCoA binding site [chemical binding]; other site 862719010460 NADH binding [chemical binding]; other site 862719010461 cationic pore residues; other site 862719010462 oxalacetate/citrate binding site [chemical binding]; other site 862719010463 coenzyme A binding site [chemical binding]; other site 862719010464 catalytic triad [active] 862719010465 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 862719010466 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719010467 active site 862719010468 HIGH motif; other site 862719010469 nucleotide binding site [chemical binding]; other site 862719010470 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 862719010471 active site 862719010472 KMSKS motif; other site 862719010473 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 862719010474 Competence protein; Region: Competence; pfam03772 862719010475 LexA repressor; Validated; Region: PRK00215 862719010476 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 862719010477 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 862719010478 Catalytic site [active] 862719010479 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 862719010480 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 862719010481 dimer interface [polypeptide binding]; other site 862719010482 putative functional site; other site 862719010483 putative MPT binding site; other site 862719010484 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 862719010485 trimer interface [polypeptide binding]; other site 862719010486 dimer interface [polypeptide binding]; other site 862719010487 putative active site [active] 862719010488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719010489 Coenzyme A binding pocket [chemical binding]; other site 862719010490 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 862719010491 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 862719010492 active site 862719010493 ribulose/triose binding site [chemical binding]; other site 862719010494 phosphate binding site [ion binding]; other site 862719010495 substrate (anthranilate) binding pocket [chemical binding]; other site 862719010496 product (indole) binding pocket [chemical binding]; other site 862719010497 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 862719010498 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 862719010499 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 862719010500 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 862719010501 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 862719010502 glutamine binding [chemical binding]; other site 862719010503 catalytic triad [active] 862719010504 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 862719010505 NodB motif; other site 862719010506 putative active site [active] 862719010507 putative catalytic site [active] 862719010508 Zn binding site [ion binding]; other site 862719010509 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862719010510 metal-binding site [ion binding] 862719010511 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 862719010512 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 862719010513 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862719010514 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719010515 catalytic residue [active] 862719010516 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 862719010517 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 862719010518 dimer interface [polypeptide binding]; other site 862719010519 active site 862719010520 catalytic residue [active] 862719010521 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 862719010522 SmpB-tmRNA interface; other site 862719010523 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 862719010524 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 862719010525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719010526 S-adenosylmethionine binding site [chemical binding]; other site 862719010527 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719010528 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862719010529 active site 862719010530 catalytic tetrad [active] 862719010531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719010532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719010533 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719010534 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 862719010535 Helix-turn-helix domain; Region: HTH_18; pfam12833 862719010536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719010537 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 862719010538 substrate binding site [chemical binding]; other site 862719010539 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 862719010540 dimer interface [polypeptide binding]; other site 862719010541 allosteric magnesium binding site [ion binding]; other site 862719010542 active site 862719010543 aspartate-rich active site metal binding site; other site 862719010544 Schiff base residues; other site 862719010545 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719010546 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 862719010547 putative active site [active] 862719010548 putative metal binding site [ion binding]; other site 862719010549 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862719010550 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 862719010551 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 862719010552 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 862719010553 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719010554 substrate binding site [chemical binding]; other site 862719010555 oxyanion hole (OAH) forming residues; other site 862719010556 trimer interface [polypeptide binding]; other site 862719010557 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 862719010558 Transcriptional regulators [Transcription]; Region: MarR; COG1846 862719010559 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 862719010560 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 862719010561 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719010562 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 862719010563 putative ligand binding site [chemical binding]; other site 862719010564 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719010565 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719010566 TM-ABC transporter signature motif; other site 862719010567 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719010568 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719010569 TM-ABC transporter signature motif; other site 862719010570 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 862719010571 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862719010572 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719010573 catalytic residue [active] 862719010574 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 862719010575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719010576 TPR motif; other site 862719010577 binding surface 862719010578 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719010579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719010580 binding surface 862719010581 TPR motif; other site 862719010582 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 862719010583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862719010584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719010585 S-adenosylmethionine binding site [chemical binding]; other site 862719010586 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719010587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719010588 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 862719010589 short chain dehydrogenase; Provisional; Region: PRK06701 862719010590 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 862719010591 NAD binding site [chemical binding]; other site 862719010592 metal binding site [ion binding]; metal-binding site 862719010593 active site 862719010594 RNA polymerase sigma factor; Provisional; Region: PRK12547 862719010595 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719010596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719010597 DNA binding residues [nucleotide binding] 862719010598 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719010599 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 862719010600 homodimer interface [polypeptide binding]; other site 862719010601 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 862719010602 active site pocket [active] 862719010603 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 862719010604 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 862719010605 Phage Tail Collar Domain; Region: Collar; pfam07484 862719010606 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 862719010607 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 862719010608 G1 box; other site 862719010609 putative GEF interaction site [polypeptide binding]; other site 862719010610 GTP/Mg2+ binding site [chemical binding]; other site 862719010611 Switch I region; other site 862719010612 G2 box; other site 862719010613 G3 box; other site 862719010614 Switch II region; other site 862719010615 G4 box; other site 862719010616 G5 box; other site 862719010617 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 862719010618 PAS fold; Region: PAS_4; pfam08448 862719010619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 862719010620 putative active site [active] 862719010621 heme pocket [chemical binding]; other site 862719010622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719010623 dimer interface [polypeptide binding]; other site 862719010624 phosphorylation site [posttranslational modification] 862719010625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719010626 ATP binding site [chemical binding]; other site 862719010627 Mg2+ binding site [ion binding]; other site 862719010628 G-X-G motif; other site 862719010629 Response regulator receiver domain; Region: Response_reg; pfam00072 862719010630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010631 active site 862719010632 phosphorylation site [posttranslational modification] 862719010633 intermolecular recognition site; other site 862719010634 dimerization interface [polypeptide binding]; other site 862719010635 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 862719010636 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 862719010637 Transglutaminase/protease-like homologues; Region: TGc; smart00460 862719010638 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 862719010639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 862719010640 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 862719010641 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 862719010642 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 862719010643 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 862719010644 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 862719010645 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 862719010646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 862719010647 short chain dehydrogenase; Provisional; Region: PRK06523 862719010648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719010649 NAD(P) binding site [chemical binding]; other site 862719010650 active site 862719010651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719010652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719010653 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 862719010654 putative effector binding pocket; other site 862719010655 putative dimerization interface [polypeptide binding]; other site 862719010656 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 862719010657 active site 862719010658 catalytic residues [active] 862719010659 Protein kinase domain; Region: Pkinase; pfam00069 862719010660 Catalytic domain of Protein Kinases; Region: PKc; cd00180 862719010661 active site 862719010662 ATP binding site [chemical binding]; other site 862719010663 substrate binding site [chemical binding]; other site 862719010664 activation loop (A-loop); other site 862719010665 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 862719010666 active site 862719010667 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 862719010668 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 862719010669 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 862719010670 TPR repeat; Region: TPR_11; pfam13414 862719010671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719010672 binding surface 862719010673 TPR motif; other site 862719010674 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719010675 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 862719010676 OstA-like protein; Region: OstA; cl00844 862719010677 Organic solvent tolerance protein; Region: OstA_C; pfam04453 862719010678 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 862719010679 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 862719010680 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 862719010681 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 862719010682 dimer interface [polypeptide binding]; other site 862719010683 active site 862719010684 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862719010685 catalytic residues [active] 862719010686 substrate binding site [chemical binding]; other site 862719010687 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 862719010688 Cupin domain; Region: Cupin_2; pfam07883 862719010689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719010690 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719010691 putative substrate translocation pore; other site 862719010692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 862719010693 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 862719010694 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 862719010695 PQQ-like domain; Region: PQQ_2; pfam13360 862719010696 Trp docking motif [polypeptide binding]; other site 862719010697 active site 862719010698 PQQ-like domain; Region: PQQ_2; pfam13360 862719010699 GTP-binding protein Der; Reviewed; Region: PRK00093 862719010700 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 862719010701 G1 box; other site 862719010702 GTP/Mg2+ binding site [chemical binding]; other site 862719010703 Switch I region; other site 862719010704 G2 box; other site 862719010705 Switch II region; other site 862719010706 G3 box; other site 862719010707 G4 box; other site 862719010708 G5 box; other site 862719010709 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 862719010710 G1 box; other site 862719010711 GTP/Mg2+ binding site [chemical binding]; other site 862719010712 Switch I region; other site 862719010713 G2 box; other site 862719010714 G3 box; other site 862719010715 Switch II region; other site 862719010716 G4 box; other site 862719010717 G5 box; other site 862719010718 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 862719010719 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 862719010720 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 862719010721 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 862719010722 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862719010723 intersubunit interface [polypeptide binding]; other site 862719010724 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 862719010725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719010726 Walker A/P-loop; other site 862719010727 ATP binding site [chemical binding]; other site 862719010728 Q-loop/lid; other site 862719010729 ABC transporter signature motif; other site 862719010730 Walker B; other site 862719010731 D-loop; other site 862719010732 H-loop/switch region; other site 862719010733 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 862719010734 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 862719010735 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 862719010736 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 862719010737 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 862719010738 Walker A/P-loop; other site 862719010739 ATP binding site [chemical binding]; other site 862719010740 Q-loop/lid; other site 862719010741 ABC transporter signature motif; other site 862719010742 Walker B; other site 862719010743 D-loop; other site 862719010744 H-loop/switch region; other site 862719010745 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 862719010746 FtsX-like permease family; Region: FtsX; pfam02687 862719010747 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719010748 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719010749 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719010750 Secretin and TonB N terminus short domain; Region: STN; smart00965 862719010751 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 862719010752 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719010753 N-terminal plug; other site 862719010754 ligand-binding site [chemical binding]; other site 862719010755 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 862719010756 FecR protein; Region: FecR; pfam04773 862719010757 RNA polymerase sigma factor; Reviewed; Region: PRK12527 862719010758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719010759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719010760 DNA binding residues [nucleotide binding] 862719010761 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 862719010762 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 862719010763 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 862719010764 dimer interface [polypeptide binding]; other site 862719010765 ADP-ribose binding site [chemical binding]; other site 862719010766 active site 862719010767 nudix motif; other site 862719010768 metal binding site [ion binding]; metal-binding site 862719010769 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 862719010770 active site 862719010771 DNA repair protein RadA; Provisional; Region: PRK11823 862719010772 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 862719010773 Walker A motif/ATP binding site; other site 862719010774 ATP binding site [chemical binding]; other site 862719010775 Walker B motif; other site 862719010776 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 862719010777 Colicin V production protein; Region: Colicin_V; pfam02674 862719010778 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 862719010779 amidophosphoribosyltransferase; Provisional; Region: PRK09123 862719010780 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 862719010781 active site 862719010782 tetramer interface [polypeptide binding]; other site 862719010783 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719010784 active site 862719010785 short chain dehydrogenase; Provisional; Region: PRK08703 862719010786 classical (c) SDRs; Region: SDR_c; cd05233 862719010787 NAD(P) binding site [chemical binding]; other site 862719010788 active site 862719010789 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 862719010790 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 862719010791 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 862719010792 active site 862719010793 substrate binding site [chemical binding]; other site 862719010794 cosubstrate binding site; other site 862719010795 catalytic site [active] 862719010796 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 862719010797 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 862719010798 dimerization interface [polypeptide binding]; other site 862719010799 putative ATP binding site [chemical binding]; other site 862719010800 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 862719010801 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 862719010802 Domain of unknown function DUF20; Region: UPF0118; pfam01594 862719010803 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 862719010804 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 862719010805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 862719010806 short chain dehydrogenase; Provisional; Region: PRK06125 862719010807 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 862719010808 putative NAD(P) binding site [chemical binding]; other site 862719010809 putative active site [active] 862719010810 MarR family; Region: MarR_2; pfam12802 862719010811 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719010812 Archaeal ATPase; Region: Arch_ATPase; pfam01637 862719010813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719010814 Walker A motif; other site 862719010815 ATP binding site [chemical binding]; other site 862719010816 N-formylglutamate amidohydrolase; Region: FGase; cl01522 862719010817 O-Antigen ligase; Region: Wzy_C; cl04850 862719010818 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 862719010819 Chain length determinant protein; Region: Wzz; cl15801 862719010820 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 862719010821 putative metal binding site; other site 862719010822 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719010823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719010824 sequence-specific DNA binding site [nucleotide binding]; other site 862719010825 salt bridge; other site 862719010826 putative glycosyl transferase; Provisional; Region: PRK10063 862719010827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719010828 active site 862719010829 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 862719010830 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 862719010831 SLBB domain; Region: SLBB; pfam10531 862719010832 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 862719010833 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 862719010834 active site 862719010835 Zn binding site [ion binding]; other site 862719010836 SprA-related family; Region: SprA-related; pfam12118 862719010837 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 862719010838 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 862719010839 putative active site; other site 862719010840 catalytic triad [active] 862719010841 putative dimer interface [polypeptide binding]; other site 862719010842 Transcriptional regulators [Transcription]; Region: MarR; COG1846 862719010843 MarR family; Region: MarR_2; cl17246 862719010844 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719010845 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719010846 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719010847 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719010848 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719010849 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719010850 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719010851 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 862719010852 PhoU domain; Region: PhoU; pfam01895 862719010853 PhoU domain; Region: PhoU; pfam01895 862719010854 anthranilate synthase; Provisional; Region: PRK13566 862719010855 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 862719010856 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 862719010857 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 862719010858 glutamine binding [chemical binding]; other site 862719010859 catalytic triad [active] 862719010860 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 862719010861 HAMP domain; Region: HAMP; pfam00672 862719010862 dimerization interface [polypeptide binding]; other site 862719010863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719010864 dimer interface [polypeptide binding]; other site 862719010865 phosphorylation site [posttranslational modification] 862719010866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719010867 ATP binding site [chemical binding]; other site 862719010868 Mg2+ binding site [ion binding]; other site 862719010869 G-X-G motif; other site 862719010870 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719010871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719010872 active site 862719010873 phosphorylation site [posttranslational modification] 862719010874 intermolecular recognition site; other site 862719010875 dimerization interface [polypeptide binding]; other site 862719010876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719010877 DNA binding site [nucleotide binding] 862719010878 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719010879 MarR family; Region: MarR_2; pfam12802 862719010880 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 862719010881 triosephosphate isomerase; Provisional; Region: PRK14565 862719010882 substrate binding site [chemical binding]; other site 862719010883 dimer interface [polypeptide binding]; other site 862719010884 catalytic triad [active] 862719010885 Preprotein translocase SecG subunit; Region: SecG; cl09123 862719010886 CTP synthetase; Validated; Region: pyrG; PRK05380 862719010887 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 862719010888 Catalytic site [active] 862719010889 active site 862719010890 UTP binding site [chemical binding]; other site 862719010891 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 862719010892 active site 862719010893 putative oxyanion hole; other site 862719010894 catalytic triad [active] 862719010895 Dienelactone hydrolase family; Region: DLH; pfam01738 862719010896 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 862719010897 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 862719010898 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 862719010899 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719010900 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719010901 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862719010902 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 862719010903 Walker A/P-loop; other site 862719010904 ATP binding site [chemical binding]; other site 862719010905 Q-loop/lid; other site 862719010906 ABC transporter signature motif; other site 862719010907 Walker B; other site 862719010908 D-loop; other site 862719010909 H-loop/switch region; other site 862719010910 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 862719010911 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 862719010912 FtsX-like permease family; Region: FtsX; pfam02687 862719010913 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 862719010914 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 862719010915 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 862719010916 active site 862719010917 (T/H)XGH motif; other site 862719010918 DNA gyrase subunit A; Validated; Region: PRK05560 862719010919 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 862719010920 CAP-like domain; other site 862719010921 active site 862719010922 primary dimer interface [polypeptide binding]; other site 862719010923 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719010924 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719010925 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719010926 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719010927 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719010928 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 862719010929 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 862719010930 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 862719010931 cation binding site [ion binding]; other site 862719010932 Predicted small secreted protein [Function unknown]; Region: COG5510 862719010933 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862719010934 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719010935 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 862719010936 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 862719010937 homotrimer interface [polypeptide binding]; other site 862719010938 Walker A motif; other site 862719010939 GTP binding site [chemical binding]; other site 862719010940 Walker B motif; other site 862719010941 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 862719010942 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 862719010943 homodimer interface [polypeptide binding]; other site 862719010944 Walker A motif; other site 862719010945 ATP binding site [chemical binding]; other site 862719010946 hydroxycobalamin binding site [chemical binding]; other site 862719010947 Walker B motif; other site 862719010948 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 862719010949 cobyric acid synthase; Provisional; Region: PRK00784 862719010950 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 862719010951 catalytic triad [active] 862719010952 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 862719010953 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 862719010954 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 862719010955 Zn binding site [ion binding]; other site 862719010956 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 862719010957 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 862719010958 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 862719010959 lipoyl attachment site [posttranslational modification]; other site 862719010960 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 862719010961 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 862719010962 tetramer interface [polypeptide binding]; other site 862719010963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719010964 catalytic residue [active] 862719010965 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 862719010966 tetramer interface [polypeptide binding]; other site 862719010967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719010968 catalytic residue [active] 862719010969 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 862719010970 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719010971 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719010972 active site 862719010973 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 862719010974 putative active site [active] 862719010975 putative substrate binding site [chemical binding]; other site 862719010976 ATP binding site [chemical binding]; other site 862719010977 Phosphotransferase enzyme family; Region: APH; pfam01636 862719010978 excinuclease ABC subunit B; Provisional; Region: PRK05298 862719010979 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719010980 ATP binding site [chemical binding]; other site 862719010981 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719010982 nucleotide binding region [chemical binding]; other site 862719010983 ATP-binding site [chemical binding]; other site 862719010984 Ultra-violet resistance protein B; Region: UvrB; pfam12344 862719010985 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 862719010986 Sel1-like repeats; Region: SEL1; smart00671 862719010987 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 862719010988 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862719010989 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719010990 catalytic residue [active] 862719010991 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719010992 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 862719010993 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 862719010994 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 862719010995 heme-binding site [chemical binding]; other site 862719010996 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719010997 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719010998 dimer interface [polypeptide binding]; other site 862719010999 putative CheW interface [polypeptide binding]; other site 862719011000 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 862719011001 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719011002 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 862719011003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719011004 DNA binding residues [nucleotide binding] 862719011005 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 862719011006 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862719011007 IHF - DNA interface [nucleotide binding]; other site 862719011008 IHF dimer interface [polypeptide binding]; other site 862719011009 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 862719011010 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 862719011011 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 862719011012 acyl-activating enzyme (AAE) consensus motif; other site 862719011013 putative AMP binding site [chemical binding]; other site 862719011014 putative active site [active] 862719011015 putative CoA binding site [chemical binding]; other site 862719011016 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 862719011017 dihydroorotase; Validated; Region: pyrC; PRK09357 862719011018 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719011019 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 862719011020 active site 862719011021 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 862719011022 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 862719011023 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 862719011024 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719011025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719011026 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 862719011027 dimerization interface [polypeptide binding]; other site 862719011028 substrate binding pocket [chemical binding]; other site 862719011029 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 862719011030 Uncharacterized conserved protein [Function unknown]; Region: COG3791 862719011031 Uncharacterized conserved protein [Function unknown]; Region: COG3791 862719011032 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 862719011033 Iron permease FTR1 family; Region: FTR1; cl00475 862719011034 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 862719011035 TrkA-N domain; Region: TrkA_N; pfam02254 862719011036 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 862719011037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719011038 Walker A/P-loop; other site 862719011039 ATP binding site [chemical binding]; other site 862719011040 Q-loop/lid; other site 862719011041 ABC transporter signature motif; other site 862719011042 Walker B; other site 862719011043 D-loop; other site 862719011044 H-loop/switch region; other site 862719011045 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719011046 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 862719011047 TM-ABC transporter signature motif; other site 862719011048 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 862719011049 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 862719011050 zinc binding site [ion binding]; other site 862719011051 putative ligand binding site [chemical binding]; other site 862719011052 Protein of unknown function (DUF983); Region: DUF983; cl02211 862719011053 short chain dehydrogenase; Provisional; Region: PRK09134 862719011054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719011055 NAD(P) binding site [chemical binding]; other site 862719011056 active site 862719011057 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 862719011058 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 862719011059 GIY-YIG motif/motif A; other site 862719011060 active site 862719011061 catalytic site [active] 862719011062 putative DNA binding site [nucleotide binding]; other site 862719011063 metal binding site [ion binding]; metal-binding site 862719011064 UvrB/uvrC motif; Region: UVR; pfam02151 862719011065 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 862719011066 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 862719011067 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 862719011068 Walker A motif; other site 862719011069 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 862719011070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719011071 motif II; other site 862719011072 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 862719011073 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 862719011074 dimer interface [polypeptide binding]; other site 862719011075 putative functional site; other site 862719011076 putative MPT binding site; other site 862719011077 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 862719011078 MoaE interaction surface [polypeptide binding]; other site 862719011079 MoeB interaction surface [polypeptide binding]; other site 862719011080 thiocarboxylated glycine; other site 862719011081 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 862719011082 MoaE homodimer interface [polypeptide binding]; other site 862719011083 MoaD interaction [polypeptide binding]; other site 862719011084 active site residues [active] 862719011085 hypothetical protein; Validated; Region: PRK00228 862719011086 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 862719011087 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 862719011088 DsbD alpha interface [polypeptide binding]; other site 862719011089 catalytic residues [active] 862719011090 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 862719011091 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 862719011092 PhnA protein; Region: PhnA; pfam03831 862719011093 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 862719011094 catalytic triad [active] 862719011095 dimer interface [polypeptide binding]; other site 862719011096 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 862719011097 RNA/DNA hybrid binding site [nucleotide binding]; other site 862719011098 active site 862719011099 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 862719011100 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 862719011101 putative active site [active] 862719011102 putative substrate binding site [chemical binding]; other site 862719011103 ATP binding site [chemical binding]; other site 862719011104 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 862719011105 dinuclear metal binding motif [ion binding]; other site 862719011106 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 862719011107 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 862719011108 active site 862719011109 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719011110 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 862719011111 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 862719011112 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719011113 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 862719011114 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 862719011115 Catalytic site; other site 862719011116 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 862719011117 two-component response regulator; Provisional; Region: PRK09191 862719011118 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 862719011119 DNA binding residues [nucleotide binding] 862719011120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011121 active site 862719011122 phosphorylation site [posttranslational modification] 862719011123 intermolecular recognition site; other site 862719011124 dimerization interface [polypeptide binding]; other site 862719011125 Predicted membrane protein [Function unknown]; Region: COG2261 862719011126 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 862719011127 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 862719011128 substrate binding site [chemical binding]; other site 862719011129 hexamer interface [polypeptide binding]; other site 862719011130 metal binding site [ion binding]; metal-binding site 862719011131 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 862719011132 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 862719011133 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 862719011134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719011135 dimer interface [polypeptide binding]; other site 862719011136 conserved gate region; other site 862719011137 putative PBP binding loops; other site 862719011138 ABC-ATPase subunit interface; other site 862719011139 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 862719011140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719011141 Walker A/P-loop; other site 862719011142 ATP binding site [chemical binding]; other site 862719011143 Q-loop/lid; other site 862719011144 ABC transporter signature motif; other site 862719011145 Walker B; other site 862719011146 D-loop; other site 862719011147 H-loop/switch region; other site 862719011148 TOBE domain; Region: TOBE; cl01440 862719011149 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 862719011150 Septum formation initiator; Region: DivIC; pfam04977 862719011151 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 862719011152 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 862719011153 tetramer interface [polypeptide binding]; other site 862719011154 TPP-binding site [chemical binding]; other site 862719011155 heterodimer interface [polypeptide binding]; other site 862719011156 phosphorylation loop region [posttranslational modification] 862719011157 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 862719011158 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862719011159 E3 interaction surface; other site 862719011160 lipoyl attachment site [posttranslational modification]; other site 862719011161 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 862719011162 alpha subunit interface [polypeptide binding]; other site 862719011163 TPP binding site [chemical binding]; other site 862719011164 heterodimer interface [polypeptide binding]; other site 862719011165 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719011166 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 862719011167 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 862719011168 E3 interaction surface; other site 862719011169 lipoyl attachment site [posttranslational modification]; other site 862719011170 e3 binding domain; Region: E3_binding; pfam02817 862719011171 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 862719011172 Chorismate mutase type II; Region: CM_2; smart00830 862719011173 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 862719011174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719011175 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862719011176 Domain of unknown function DUF29; Region: DUF29; pfam01724 862719011177 lipoyl synthase; Provisional; Region: PRK05481 862719011178 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719011179 FeS/SAM binding site; other site 862719011180 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 862719011181 putative coenzyme Q binding site [chemical binding]; other site 862719011182 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 862719011183 active site 1 [active] 862719011184 dimer interface [polypeptide binding]; other site 862719011185 hexamer interface [polypeptide binding]; other site 862719011186 active site 2 [active] 862719011187 Competence-damaged protein; Region: CinA; pfam02464 862719011188 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 862719011189 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 862719011190 substrate binding site; other site 862719011191 dimer interface; other site 862719011192 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 862719011193 homotrimer interaction site [polypeptide binding]; other site 862719011194 zinc binding site [ion binding]; other site 862719011195 CDP-binding sites; other site 862719011196 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 862719011197 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 862719011198 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 862719011199 FMN binding site [chemical binding]; other site 862719011200 active site 862719011201 catalytic residues [active] 862719011202 substrate binding site [chemical binding]; other site 862719011203 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862719011204 PAS domain; Region: PAS; smart00091 862719011205 putative active site [active] 862719011206 heme pocket [chemical binding]; other site 862719011207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719011208 dimer interface [polypeptide binding]; other site 862719011209 phosphorylation site [posttranslational modification] 862719011210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011211 ATP binding site [chemical binding]; other site 862719011212 Mg2+ binding site [ion binding]; other site 862719011213 G-X-G motif; other site 862719011214 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 862719011215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011216 active site 862719011217 phosphorylation site [posttranslational modification] 862719011218 intermolecular recognition site; other site 862719011219 dimerization interface [polypeptide binding]; other site 862719011220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719011221 Walker A motif; other site 862719011222 ATP binding site [chemical binding]; other site 862719011223 Walker B motif; other site 862719011224 arginine finger; other site 862719011225 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 862719011226 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 862719011227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719011228 dimerization interface [polypeptide binding]; other site 862719011229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719011230 dimer interface [polypeptide binding]; other site 862719011231 phosphorylation site [posttranslational modification] 862719011232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011233 ATP binding site [chemical binding]; other site 862719011234 Mg2+ binding site [ion binding]; other site 862719011235 G-X-G motif; other site 862719011236 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719011237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011238 active site 862719011239 phosphorylation site [posttranslational modification] 862719011240 intermolecular recognition site; other site 862719011241 dimerization interface [polypeptide binding]; other site 862719011242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719011243 Walker A motif; other site 862719011244 ATP binding site [chemical binding]; other site 862719011245 Walker B motif; other site 862719011246 arginine finger; other site 862719011247 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719011248 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 862719011249 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 862719011250 putative active site [active] 862719011251 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 862719011252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719011253 motif II; other site 862719011254 bacterial Hfq-like; Region: Hfq; cd01716 862719011255 hexamer interface [polypeptide binding]; other site 862719011256 Sm1 motif; other site 862719011257 RNA binding site [nucleotide binding]; other site 862719011258 Sm2 motif; other site 862719011259 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 862719011260 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 862719011261 HflX GTPase family; Region: HflX; cd01878 862719011262 G1 box; other site 862719011263 GTP/Mg2+ binding site [chemical binding]; other site 862719011264 Switch I region; other site 862719011265 G2 box; other site 862719011266 G3 box; other site 862719011267 Switch II region; other site 862719011268 G4 box; other site 862719011269 G5 box; other site 862719011270 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 862719011271 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 862719011272 active site 862719011273 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719011274 Ligand Binding Site [chemical binding]; other site 862719011275 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719011276 Ligand Binding Site [chemical binding]; other site 862719011277 NMT1/THI5 like; Region: NMT1; pfam09084 862719011278 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 862719011279 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719011280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719011281 dimer interface [polypeptide binding]; other site 862719011282 conserved gate region; other site 862719011283 ABC-ATPase subunit interface; other site 862719011284 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719011285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719011286 Walker A/P-loop; other site 862719011287 ATP binding site [chemical binding]; other site 862719011288 Q-loop/lid; other site 862719011289 ABC transporter signature motif; other site 862719011290 Walker B; other site 862719011291 D-loop; other site 862719011292 H-loop/switch region; other site 862719011293 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 862719011294 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 862719011295 active site 862719011296 Zn binding site [ion binding]; other site 862719011297 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 862719011298 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011300 active site 862719011301 phosphorylation site [posttranslational modification] 862719011302 intermolecular recognition site; other site 862719011303 dimerization interface [polypeptide binding]; other site 862719011304 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 862719011305 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 862719011306 dimer interface [polypeptide binding]; other site 862719011307 ssDNA binding site [nucleotide binding]; other site 862719011308 tetramer (dimer of dimers) interface [polypeptide binding]; other site 862719011309 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719011310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719011311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719011312 dimerization interface [polypeptide binding]; other site 862719011313 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 862719011314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719011315 putative substrate translocation pore; other site 862719011316 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 862719011317 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 862719011318 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 862719011319 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 862719011320 Protein of unknown function DUF58; Region: DUF58; pfam01882 862719011321 MoxR-like ATPases [General function prediction only]; Region: COG0714 862719011322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719011323 Walker A motif; other site 862719011324 ATP binding site [chemical binding]; other site 862719011325 Walker B motif; other site 862719011326 arginine finger; other site 862719011327 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 862719011328 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 862719011329 putative active site [active] 862719011330 putative CoA binding site [chemical binding]; other site 862719011331 nudix motif; other site 862719011332 metal binding site [ion binding]; metal-binding site 862719011333 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 862719011334 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 862719011335 active site 862719011336 NTP binding site [chemical binding]; other site 862719011337 metal binding triad [ion binding]; metal-binding site 862719011338 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 862719011339 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 862719011340 short chain dehydrogenase; Provisional; Region: PRK07478 862719011341 classical (c) SDRs; Region: SDR_c; cd05233 862719011342 NAD(P) binding site [chemical binding]; other site 862719011343 active site 862719011344 exopolyphosphatase; Region: exo_poly_only; TIGR03706 862719011345 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 862719011346 polyphosphate kinase; Provisional; Region: PRK05443 862719011347 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 862719011348 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 862719011349 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 862719011350 putative domain interface [polypeptide binding]; other site 862719011351 putative active site [active] 862719011352 catalytic site [active] 862719011353 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 862719011354 putative domain interface [polypeptide binding]; other site 862719011355 putative active site [active] 862719011356 catalytic site [active] 862719011357 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719011358 catalytic core [active] 862719011359 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 862719011360 putative active site [active] 862719011361 putative metal binding residues [ion binding]; other site 862719011362 signature motif; other site 862719011363 putative triphosphate binding site [ion binding]; other site 862719011364 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 862719011365 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 862719011366 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 862719011367 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 862719011368 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 862719011369 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 862719011370 Glucose inhibited division protein A; Region: GIDA; pfam01134 862719011371 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 862719011372 substrate binding pocket [chemical binding]; other site 862719011373 substrate-Mg2+ binding site; other site 862719011374 aspartate-rich region 1; other site 862719011375 aspartate-rich region 2; other site 862719011376 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 862719011377 active site lid residues [active] 862719011378 substrate binding pocket [chemical binding]; other site 862719011379 catalytic residues [active] 862719011380 substrate-Mg2+ binding site; other site 862719011381 aspartate-rich region 1; other site 862719011382 aspartate-rich region 2; other site 862719011383 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 862719011384 active site lid residues [active] 862719011385 substrate binding pocket [chemical binding]; other site 862719011386 catalytic residues [active] 862719011387 substrate-Mg2+ binding site; other site 862719011388 aspartate-rich region 1; other site 862719011389 aspartate-rich region 2; other site 862719011390 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 862719011391 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 862719011392 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 862719011393 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 862719011394 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 862719011395 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 862719011396 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 862719011397 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 862719011398 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 862719011399 Protein export membrane protein; Region: SecD_SecF; pfam02355 862719011400 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 862719011401 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 862719011402 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 862719011403 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 862719011404 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 862719011405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719011406 Walker A motif; other site 862719011407 ATP binding site [chemical binding]; other site 862719011408 Walker B motif; other site 862719011409 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 862719011410 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 862719011411 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 862719011412 Peptidase family M23; Region: Peptidase_M23; pfam01551 862719011413 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 862719011414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719011415 S-adenosylmethionine binding site [chemical binding]; other site 862719011416 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 862719011417 seryl-tRNA synthetase; Provisional; Region: PRK05431 862719011418 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 862719011419 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 862719011420 dimer interface [polypeptide binding]; other site 862719011421 active site 862719011422 motif 1; other site 862719011423 motif 2; other site 862719011424 motif 3; other site 862719011425 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719011426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719011427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011428 active site 862719011429 phosphorylation site [posttranslational modification] 862719011430 intermolecular recognition site; other site 862719011431 dimerization interface [polypeptide binding]; other site 862719011432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719011433 DNA binding residues [nucleotide binding] 862719011434 dimerization interface [polypeptide binding]; other site 862719011435 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719011436 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719011437 DNA binding residues [nucleotide binding] 862719011438 dimerization interface [polypeptide binding]; other site 862719011439 HAMP domain; Region: HAMP; pfam00672 862719011440 dimerization interface [polypeptide binding]; other site 862719011441 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719011442 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719011443 dimer interface [polypeptide binding]; other site 862719011444 putative CheW interface [polypeptide binding]; other site 862719011445 PilZ domain; Region: PilZ; pfam07238 862719011446 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 862719011447 dimer interface [polypeptide binding]; other site 862719011448 putative tRNA-binding site [nucleotide binding]; other site 862719011449 Phasin protein; Region: Phasin_2; pfam09361 862719011450 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 862719011451 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 862719011452 putative deacylase active site [active] 862719011453 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 862719011454 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 862719011455 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 862719011456 Membrane fusogenic activity; Region: BMFP; pfam04380 862719011457 AsmA family; Region: AsmA; pfam05170 862719011458 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 862719011459 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 862719011460 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 862719011461 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 862719011462 NAD(P) binding site [chemical binding]; other site 862719011463 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 862719011464 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 862719011465 Flavoprotein; Region: Flavoprotein; pfam02441 862719011466 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 862719011467 active site clefts [active] 862719011468 zinc binding site [ion binding]; other site 862719011469 dimer interface [polypeptide binding]; other site 862719011470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719011471 binding surface 862719011472 TPR motif; other site 862719011473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 862719011474 TPR motif; other site 862719011475 binding surface 862719011476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719011477 binding surface 862719011478 TPR repeat; Region: TPR_11; pfam13414 862719011479 TPR motif; other site 862719011480 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 862719011481 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 862719011482 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 862719011483 active site 862719011484 ADP/pyrophosphate binding site [chemical binding]; other site 862719011485 dimerization interface [polypeptide binding]; other site 862719011486 allosteric effector site; other site 862719011487 fructose-1,6-bisphosphate binding site; other site 862719011488 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 862719011489 apolar tunnel; other site 862719011490 heme binding site [chemical binding]; other site 862719011491 dimerization interface [polypeptide binding]; other site 862719011492 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 862719011493 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 862719011494 ATP-grasp domain; Region: ATP-grasp; pfam02222 862719011495 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719011496 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719011497 Protein of unknown function, DUF599; Region: DUF599; pfam04654 862719011498 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 862719011499 fumarate hydratase; Reviewed; Region: fumC; PRK00485 862719011500 Class II fumarases; Region: Fumarase_classII; cd01362 862719011501 active site 862719011502 tetramer interface [polypeptide binding]; other site 862719011503 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 862719011504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719011505 Coenzyme A binding pocket [chemical binding]; other site 862719011506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 862719011507 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 862719011508 Transglycosylase SLT domain; Region: SLT_2; pfam13406 862719011509 murein hydrolase B; Provisional; Region: PRK10760; cl17906 862719011510 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 862719011511 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011513 active site 862719011514 phosphorylation site [posttranslational modification] 862719011515 intermolecular recognition site; other site 862719011516 dimerization interface [polypeptide binding]; other site 862719011517 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 862719011518 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 862719011519 dimer interface [polypeptide binding]; other site 862719011520 PYR/PP interface [polypeptide binding]; other site 862719011521 TPP binding site [chemical binding]; other site 862719011522 substrate binding site [chemical binding]; other site 862719011523 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 862719011524 TPP-binding site; other site 862719011525 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 862719011526 PAS domain; Region: PAS; smart00091 862719011527 PAS fold; Region: PAS_7; pfam12860 862719011528 PAS fold; Region: PAS_7; pfam12860 862719011529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719011530 putative active site [active] 862719011531 heme pocket [chemical binding]; other site 862719011532 PAS fold; Region: PAS_4; pfam08448 862719011533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719011534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719011535 dimer interface [polypeptide binding]; other site 862719011536 phosphorylation site [posttranslational modification] 862719011537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011538 ATP binding site [chemical binding]; other site 862719011539 Mg2+ binding site [ion binding]; other site 862719011540 G-X-G motif; other site 862719011541 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 862719011542 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 862719011543 active site 862719011544 Zn binding site [ion binding]; other site 862719011545 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 862719011546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 862719011547 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 862719011548 Subunit III/VIIa interface [polypeptide binding]; other site 862719011549 Phospholipid binding site [chemical binding]; other site 862719011550 Subunit I/III interface [polypeptide binding]; other site 862719011551 Subunit III/VIb interface [polypeptide binding]; other site 862719011552 Subunit III/VIa interface; other site 862719011553 Subunit III/Vb interface [polypeptide binding]; other site 862719011554 Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175 862719011555 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 862719011556 UbiA prenyltransferase family; Region: UbiA; pfam01040 862719011557 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 862719011558 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 862719011559 Subunit I/III interface [polypeptide binding]; other site 862719011560 D-pathway; other site 862719011561 Subunit I/VIIc interface [polypeptide binding]; other site 862719011562 Subunit I/IV interface [polypeptide binding]; other site 862719011563 Subunit I/II interface [polypeptide binding]; other site 862719011564 Low-spin heme (heme a) binding site [chemical binding]; other site 862719011565 Subunit I/VIIa interface [polypeptide binding]; other site 862719011566 Subunit I/VIa interface [polypeptide binding]; other site 862719011567 Dimer interface; other site 862719011568 Putative water exit pathway; other site 862719011569 Binuclear center (heme a3/CuB) [ion binding]; other site 862719011570 K-pathway; other site 862719011571 Subunit I/Vb interface [polypeptide binding]; other site 862719011572 Putative proton exit pathway; other site 862719011573 Subunit I/VIb interface; other site 862719011574 Subunit I/VIc interface [polypeptide binding]; other site 862719011575 Electron transfer pathway; other site 862719011576 Subunit I/VIIIb interface [polypeptide binding]; other site 862719011577 Subunit I/VIIb interface [polypeptide binding]; other site 862719011578 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 862719011579 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 862719011580 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 862719011581 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 862719011582 protease TldD; Provisional; Region: tldD; PRK10735 862719011583 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 862719011584 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 862719011585 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 862719011586 multidrug efflux system protein; Provisional; Region: PRK11431 862719011587 Uncharacterized conserved protein [Function unknown]; Region: COG2938 862719011588 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 862719011589 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 862719011590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719011591 ATP binding site [chemical binding]; other site 862719011592 putative Mg++ binding site [ion binding]; other site 862719011593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719011594 nucleotide binding region [chemical binding]; other site 862719011595 ATP-binding site [chemical binding]; other site 862719011596 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 862719011597 Family description; Region: ACT_7; pfam13840 862719011598 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 862719011599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719011600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719011601 WHG domain; Region: WHG; pfam13305 862719011602 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 862719011603 nucleotide binding site/active site [active] 862719011604 HIT family signature motif; other site 862719011605 catalytic residue [active] 862719011606 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 862719011607 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719011608 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 862719011609 Ligand binding site; other site 862719011610 DXD motif; other site 862719011611 Cupin domain; Region: Cupin_2; cl17218 862719011612 recombinase A; Provisional; Region: recA; PRK09354 862719011613 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 862719011614 hexamer interface [polypeptide binding]; other site 862719011615 Walker A motif; other site 862719011616 ATP binding site [chemical binding]; other site 862719011617 Walker B motif; other site 862719011618 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862719011619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719011620 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862719011621 putative active site [active] 862719011622 heme pocket [chemical binding]; other site 862719011623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719011624 dimer interface [polypeptide binding]; other site 862719011625 phosphorylation site [posttranslational modification] 862719011626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011627 ATP binding site [chemical binding]; other site 862719011628 Mg2+ binding site [ion binding]; other site 862719011629 G-X-G motif; other site 862719011630 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011632 active site 862719011633 phosphorylation site [posttranslational modification] 862719011634 intermolecular recognition site; other site 862719011635 dimerization interface [polypeptide binding]; other site 862719011636 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 862719011637 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 862719011638 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 862719011639 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 862719011640 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 862719011641 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 862719011642 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862719011643 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 862719011644 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 862719011645 Evidence 2b : Function of strongly homologous gene; Product type s : structure 862719011646 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 862719011647 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 862719011648 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 862719011649 potassium uptake protein; Region: kup; TIGR00794 862719011650 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 862719011651 Fasciclin domain; Region: Fasciclin; pfam02469 862719011652 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719011653 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 862719011654 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 862719011655 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 862719011656 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 862719011657 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 862719011658 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 862719011659 active site 862719011660 nucleophile elbow; other site 862719011661 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 862719011662 active site 862719011663 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 862719011664 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 862719011665 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 862719011666 GTPase Era; Reviewed; Region: era; PRK00089 862719011667 G1 box; other site 862719011668 GTP/Mg2+ binding site [chemical binding]; other site 862719011669 Switch I region; other site 862719011670 G2 box; other site 862719011671 Switch II region; other site 862719011672 G3 box; other site 862719011673 G4 box; other site 862719011674 G5 box; other site 862719011675 KH domain; Region: KH_2; pfam07650 862719011676 ribonuclease III; Reviewed; Region: rnc; PRK00102 862719011677 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 862719011678 dimerization interface [polypeptide binding]; other site 862719011679 active site 862719011680 metal binding site [ion binding]; metal-binding site 862719011681 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 862719011682 dsRNA binding site [nucleotide binding]; other site 862719011683 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 862719011684 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 862719011685 Catalytic site [active] 862719011686 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 862719011687 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 862719011688 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 862719011689 active site 862719011690 hydrophilic channel; other site 862719011691 dimerization interface [polypeptide binding]; other site 862719011692 catalytic residues [active] 862719011693 active site lid [active] 862719011694 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 862719011695 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719011696 Zn2+ binding site [ion binding]; other site 862719011697 Mg2+ binding site [ion binding]; other site 862719011698 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 862719011699 synthetase active site [active] 862719011700 NTP binding site [chemical binding]; other site 862719011701 metal binding site [ion binding]; metal-binding site 862719011702 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 862719011703 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 862719011704 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 862719011705 LabA_like proteins; Region: LabA; cd10911 862719011706 Uncharacterized conserved protein [Function unknown]; Region: COG1432 862719011707 putative metal binding site [ion binding]; other site 862719011708 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 862719011709 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 862719011710 SurA N-terminal domain; Region: SurA_N; pfam09312 862719011711 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 862719011712 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 862719011713 Predicted permeases [General function prediction only]; Region: COG0795 862719011714 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 862719011715 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 862719011716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719011717 Coenzyme A binding pocket [chemical binding]; other site 862719011718 GMP synthase; Reviewed; Region: guaA; PRK00074 862719011719 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 862719011720 AMP/PPi binding site [chemical binding]; other site 862719011721 candidate oxyanion hole; other site 862719011722 catalytic triad [active] 862719011723 potential glutamine specificity residues [chemical binding]; other site 862719011724 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 862719011725 ATP Binding subdomain [chemical binding]; other site 862719011726 Ligand Binding sites [chemical binding]; other site 862719011727 Dimerization subdomain; other site 862719011728 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719011729 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 862719011730 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862719011731 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719011732 catalytic residue [active] 862719011733 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719011734 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719011735 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719011736 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862719011737 Protein export membrane protein; Region: SecD_SecF; cl14618 862719011738 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 862719011739 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 862719011740 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 862719011741 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 862719011742 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 862719011743 DEAD-like helicases superfamily; Region: DEXDc; smart00487 862719011744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719011745 ATP binding site [chemical binding]; other site 862719011746 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719011747 nucleotide binding region [chemical binding]; other site 862719011748 ATP-binding site [chemical binding]; other site 862719011749 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 862719011750 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 862719011751 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 862719011752 SlyX; Region: SlyX; pfam04102 862719011753 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 862719011754 Multicopper oxidase; Region: Cu-oxidase; pfam00394 862719011755 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 862719011756 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 862719011757 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719011758 Winged helix-turn helix; Region: HTH_29; pfam13551 862719011759 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719011760 Homeodomain-like domain; Region: HTH_32; pfam13565 862719011761 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 862719011762 Transglycosylase; Region: Transgly; pfam00912 862719011763 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 862719011764 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 862719011765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719011766 binding surface 862719011767 TPR motif; other site 862719011768 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 862719011769 MG2 domain; Region: A2M_N; pfam01835 862719011770 Alpha-2-macroglobulin family; Region: A2M; pfam00207 862719011771 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 862719011772 surface patch; other site 862719011773 thioester region; other site 862719011774 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 862719011775 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 862719011776 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 862719011777 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 862719011778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719011779 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 862719011780 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 862719011781 putative dimerization interface [polypeptide binding]; other site 862719011782 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 862719011783 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 862719011784 dimer interface [polypeptide binding]; other site 862719011785 putative functional site; other site 862719011786 putative MPT binding site; other site 862719011787 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 862719011788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719011789 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 862719011790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011791 ATP binding site [chemical binding]; other site 862719011792 Mg2+ binding site [ion binding]; other site 862719011793 G-X-G motif; other site 862719011794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011795 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719011796 active site 862719011797 phosphorylation site [posttranslational modification] 862719011798 intermolecular recognition site; other site 862719011799 dimerization interface [polypeptide binding]; other site 862719011800 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 862719011801 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 862719011802 putative active site [active] 862719011803 homoserine dehydrogenase; Provisional; Region: PRK06349 862719011804 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 862719011805 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 862719011806 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 862719011807 aminotransferase; Validated; Region: PRK09148 862719011808 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719011809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719011810 homodimer interface [polypeptide binding]; other site 862719011811 catalytic residue [active] 862719011812 Nitrate and nitrite sensing; Region: NIT; pfam08376 862719011813 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719011814 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719011815 dimer interface [polypeptide binding]; other site 862719011816 putative CheW interface [polypeptide binding]; other site 862719011817 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 862719011818 Response regulator receiver domain; Region: Response_reg; pfam00072 862719011819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011820 active site 862719011821 phosphorylation site [posttranslational modification] 862719011822 intermolecular recognition site; other site 862719011823 dimerization interface [polypeptide binding]; other site 862719011824 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 862719011825 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 862719011826 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 862719011827 tandem repeat interface [polypeptide binding]; other site 862719011828 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 862719011829 oligomer interface [polypeptide binding]; other site 862719011830 active site residues [active] 862719011831 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 862719011832 tandem repeat interface [polypeptide binding]; other site 862719011833 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 862719011834 oligomer interface [polypeptide binding]; other site 862719011835 active site residues [active] 862719011836 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 862719011837 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862719011838 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862719011839 ABC transporter; Region: ABC_tran_2; pfam12848 862719011840 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862719011841 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 862719011842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719011843 S-adenosylmethionine binding site [chemical binding]; other site 862719011844 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 862719011845 MutS domain I; Region: MutS_I; pfam01624 862719011846 MutS domain II; Region: MutS_II; pfam05188 862719011847 MutS domain III; Region: MutS_III; pfam05192 862719011848 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 862719011849 Walker A/P-loop; other site 862719011850 ATP binding site [chemical binding]; other site 862719011851 Q-loop/lid; other site 862719011852 ABC transporter signature motif; other site 862719011853 Walker B; other site 862719011854 D-loop; other site 862719011855 H-loop/switch region; other site 862719011856 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 862719011857 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 862719011858 HIGH motif; other site 862719011859 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 862719011860 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 862719011861 active site 862719011862 KMSKS motif; other site 862719011863 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 862719011864 tRNA binding surface [nucleotide binding]; other site 862719011865 anticodon binding site; other site 862719011866 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 862719011867 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 862719011868 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 862719011869 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 862719011870 active site residue [active] 862719011871 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 862719011872 Methyltransferase domain; Region: Methyltransf_18; pfam12847 862719011873 S-adenosylmethionine binding site [chemical binding]; other site 862719011874 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 862719011875 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862719011876 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719011877 protein binding site [polypeptide binding]; other site 862719011878 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 862719011879 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 862719011880 dimer interface [polypeptide binding]; other site 862719011881 ADP-ribose binding site [chemical binding]; other site 862719011882 active site 862719011883 nudix motif; other site 862719011884 metal binding site [ion binding]; metal-binding site 862719011885 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 862719011886 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 862719011887 dimer interface [polypeptide binding]; other site 862719011888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719011889 catalytic residue [active] 862719011890 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1712632, 6256345, 7005898, 7025207; Product type e : enzyme 862719011891 3-mercaptopyruvate sulfurtransferase; Region: PLN02723 862719011892 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 862719011893 active site residue [active] 862719011894 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 862719011895 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 862719011896 active site residue [active] 862719011897 putative acetyltransferase; Provisional; Region: PRK03624 862719011898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719011899 Coenzyme A binding pocket [chemical binding]; other site 862719011900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719011901 Coenzyme A binding pocket [chemical binding]; other site 862719011902 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 862719011903 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719011904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719011905 homodimer interface [polypeptide binding]; other site 862719011906 catalytic residue [active] 862719011907 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719011908 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 862719011909 Walker A/P-loop; other site 862719011910 ATP binding site [chemical binding]; other site 862719011911 Q-loop/lid; other site 862719011912 ABC transporter signature motif; other site 862719011913 Walker B; other site 862719011914 D-loop; other site 862719011915 H-loop/switch region; other site 862719011916 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719011917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719011918 dimer interface [polypeptide binding]; other site 862719011919 conserved gate region; other site 862719011920 putative PBP binding loops; other site 862719011921 ABC-ATPase subunit interface; other site 862719011922 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 862719011923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719011924 conserved gate region; other site 862719011925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719011926 dimer interface [polypeptide binding]; other site 862719011927 conserved gate region; other site 862719011928 putative PBP binding loops; other site 862719011929 ABC-ATPase subunit interface; other site 862719011930 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 862719011931 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719011932 substrate binding pocket [chemical binding]; other site 862719011933 membrane-bound complex binding site; other site 862719011934 hinge residues; other site 862719011935 cystathionine beta-lyase; Provisional; Region: PRK09028 862719011936 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719011937 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719011938 catalytic residue [active] 862719011939 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 862719011940 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 862719011941 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 862719011942 DctM-like transporters; Region: DctM; pfam06808 862719011943 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 862719011944 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 862719011945 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 862719011946 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 862719011947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 862719011948 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 862719011949 Uncharacterized conserved protein [Function unknown]; Region: COG2308 862719011950 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 862719011951 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719011952 ligand binding site [chemical binding]; other site 862719011953 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 862719011954 SCP-2 sterol transfer family; Region: SCP2; pfam02036 862719011955 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 862719011956 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 862719011957 acyl-activating enzyme (AAE) consensus motif; other site 862719011958 putative AMP binding site [chemical binding]; other site 862719011959 putative active site [active] 862719011960 putative CoA binding site [chemical binding]; other site 862719011961 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 862719011962 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 862719011963 DNA binding residues [nucleotide binding] 862719011964 putative dimer interface [polypeptide binding]; other site 862719011965 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862719011966 active site 862719011967 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 862719011968 Ligand binding site [chemical binding]; other site 862719011969 Electron transfer flavoprotein domain; Region: ETF; pfam01012 862719011970 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 862719011971 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 862719011972 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 862719011973 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 862719011974 PAS fold; Region: PAS_3; pfam08447 862719011975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719011976 heme pocket [chemical binding]; other site 862719011977 putative active site [active] 862719011978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719011979 PAS fold; Region: PAS_3; pfam08447 862719011980 putative active site [active] 862719011981 heme pocket [chemical binding]; other site 862719011982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011983 ATP binding site [chemical binding]; other site 862719011984 Mg2+ binding site [ion binding]; other site 862719011985 G-X-G motif; other site 862719011986 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719011987 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 862719011988 dimer interface [polypeptide binding]; other site 862719011989 phosphorylation site [posttranslational modification] 862719011990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719011991 ATP binding site [chemical binding]; other site 862719011992 Mg2+ binding site [ion binding]; other site 862719011993 G-X-G motif; other site 862719011994 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719011995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719011996 active site 862719011997 phosphorylation site [posttranslational modification] 862719011998 intermolecular recognition site; other site 862719011999 dimerization interface [polypeptide binding]; other site 862719012000 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 862719012001 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 862719012002 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 862719012003 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 862719012004 homodimer interface [polypeptide binding]; other site 862719012005 substrate-cofactor binding pocket; other site 862719012006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719012007 catalytic residue [active] 862719012008 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 862719012009 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 862719012010 OsmC-like protein; Region: OsmC; cl00767 862719012011 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 862719012012 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 862719012013 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719012014 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719012015 DNA binding residues [nucleotide binding] 862719012016 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 862719012017 Sel1-like repeats; Region: SEL1; smart00671 862719012018 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 862719012019 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862719012020 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719012021 catalytic residue [active] 862719012022 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 862719012023 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719012024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012025 S-adenosylmethionine binding site [chemical binding]; other site 862719012026 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719012027 AsnC family; Region: AsnC_trans_reg; pfam01037 862719012028 helicase 45; Provisional; Region: PTZ00424 862719012029 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 862719012030 ATP binding site [chemical binding]; other site 862719012031 Mg++ binding site [ion binding]; other site 862719012032 motif III; other site 862719012033 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719012034 nucleotide binding region [chemical binding]; other site 862719012035 ATP-binding site [chemical binding]; other site 862719012036 Isochorismatase family; Region: Isochorismatase; pfam00857 862719012037 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 862719012038 catalytic triad [active] 862719012039 dimer interface [polypeptide binding]; other site 862719012040 conserved cis-peptide bond; other site 862719012041 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 862719012042 TAP-like protein; Region: Abhydrolase_4; pfam08386 862719012043 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 862719012044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012045 Mg2+ binding site [ion binding]; other site 862719012046 G-X-G motif; other site 862719012047 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 862719012048 anchoring element; other site 862719012049 dimer interface [polypeptide binding]; other site 862719012050 ATP binding site [chemical binding]; other site 862719012051 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 862719012052 active site 862719012053 putative metal-binding site [ion binding]; other site 862719012054 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 862719012055 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 862719012056 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719012057 NMT1/THI5 like; Region: NMT1; pfam09084 862719012058 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719012059 substrate binding pocket [chemical binding]; other site 862719012060 membrane-bound complex binding site; other site 862719012061 hinge residues; other site 862719012062 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719012063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719012064 dimer interface [polypeptide binding]; other site 862719012065 conserved gate region; other site 862719012066 putative PBP binding loops; other site 862719012067 ABC-ATPase subunit interface; other site 862719012068 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719012069 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 862719012070 Walker A/P-loop; other site 862719012071 ATP binding site [chemical binding]; other site 862719012072 Q-loop/lid; other site 862719012073 ABC transporter signature motif; other site 862719012074 Walker B; other site 862719012075 D-loop; other site 862719012076 H-loop/switch region; other site 862719012077 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 862719012078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719012079 Walker A motif; other site 862719012080 ATP binding site [chemical binding]; other site 862719012081 Walker B motif; other site 862719012082 arginine finger; other site 862719012083 Peptidase family M41; Region: Peptidase_M41; pfam01434 862719012084 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 862719012085 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719012086 substrate binding pocket [chemical binding]; other site 862719012087 membrane-bound complex binding site; other site 862719012088 hinge residues; other site 862719012089 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719012090 dimerization interface [polypeptide binding]; other site 862719012091 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 862719012092 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719012093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012094 active site 862719012095 phosphorylation site [posttranslational modification] 862719012096 intermolecular recognition site; other site 862719012097 dimerization interface [polypeptide binding]; other site 862719012098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719012099 DNA binding site [nucleotide binding] 862719012100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719012101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012102 ATP binding site [chemical binding]; other site 862719012103 Mg2+ binding site [ion binding]; other site 862719012104 G-X-G motif; other site 862719012105 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 862719012106 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719012107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012108 active site 862719012109 phosphorylation site [posttranslational modification] 862719012110 intermolecular recognition site; other site 862719012111 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719012112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719012113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719012114 dimer interface [polypeptide binding]; other site 862719012115 phosphorylation site [posttranslational modification] 862719012116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012117 ATP binding site [chemical binding]; other site 862719012118 Mg2+ binding site [ion binding]; other site 862719012119 G-X-G motif; other site 862719012120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719012121 Histidine kinase; Region: HisKA_2; pfam07568 862719012122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012123 ATP binding site [chemical binding]; other site 862719012124 Mg2+ binding site [ion binding]; other site 862719012125 G-X-G motif; other site 862719012126 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719012127 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719012128 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 862719012129 metal binding site [ion binding]; metal-binding site 862719012130 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719012131 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719012132 ligand binding site [chemical binding]; other site 862719012133 flexible hinge region; other site 862719012134 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 862719012135 putative switch regulator; other site 862719012136 non-specific DNA interactions [nucleotide binding]; other site 862719012137 DNA binding site [nucleotide binding] 862719012138 sequence specific DNA binding site [nucleotide binding]; other site 862719012139 putative cAMP binding site [chemical binding]; other site 862719012140 Uncharacterized conserved protein [Function unknown]; Region: COG2928 862719012141 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 862719012142 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 862719012143 generic binding surface II; other site 862719012144 ssDNA binding site; other site 862719012145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719012146 ATP binding site [chemical binding]; other site 862719012147 putative Mg++ binding site [ion binding]; other site 862719012148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719012149 nucleotide binding region [chemical binding]; other site 862719012150 ATP-binding site [chemical binding]; other site 862719012151 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719012152 putative binding surface; other site 862719012153 active site 862719012154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012155 ATP binding site [chemical binding]; other site 862719012156 Mg2+ binding site [ion binding]; other site 862719012157 G-X-G motif; other site 862719012158 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 862719012159 Response regulator receiver domain; Region: Response_reg; pfam00072 862719012160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012161 active site 862719012162 phosphorylation site [posttranslational modification] 862719012163 intermolecular recognition site; other site 862719012164 dimerization interface [polypeptide binding]; other site 862719012165 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 862719012166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012167 active site 862719012168 phosphorylation site [posttranslational modification] 862719012169 intermolecular recognition site; other site 862719012170 CheB methylesterase; Region: CheB_methylest; pfam01339 862719012171 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 862719012172 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 862719012173 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 862719012174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012175 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719012176 dimer interface [polypeptide binding]; other site 862719012177 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719012178 putative CheW interface [polypeptide binding]; other site 862719012179 HAMP domain; Region: HAMP; pfam00672 862719012180 dimerization interface [polypeptide binding]; other site 862719012181 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719012182 dimer interface [polypeptide binding]; other site 862719012183 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719012184 putative CheW interface [polypeptide binding]; other site 862719012185 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 862719012186 YceG-like family; Region: YceG; pfam02618 862719012187 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 862719012188 dimerization interface [polypeptide binding]; other site 862719012189 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 862719012190 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 862719012191 dimer interface [polypeptide binding]; other site 862719012192 active site 862719012193 acyl carrier protein; Provisional; Region: acpP; PRK00982 862719012194 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 862719012195 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 862719012196 NAD(P) binding site [chemical binding]; other site 862719012197 homotetramer interface [polypeptide binding]; other site 862719012198 homodimer interface [polypeptide binding]; other site 862719012199 active site 862719012200 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 862719012201 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 862719012202 Acyltransferase family; Region: Acyl_transf_3; pfam01757 862719012203 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 862719012204 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 862719012205 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 862719012206 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 862719012207 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 862719012208 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 862719012209 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 862719012210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012211 S-adenosylmethionine binding site [chemical binding]; other site 862719012212 isocitrate dehydrogenase; Validated; Region: PRK08299 862719012213 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 862719012214 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 862719012215 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 862719012216 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 862719012217 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719012218 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 862719012219 GcrA cell cycle regulator; Region: GcrA; cl11564 862719012220 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 862719012221 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 862719012222 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 862719012223 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719012224 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719012225 DNA binding residues [nucleotide binding] 862719012226 isocitrate dehydrogenase; Validated; Region: PRK09222 862719012227 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 862719012228 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 862719012229 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 862719012230 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 862719012231 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 862719012232 DNA-binding interface [nucleotide binding]; DNA binding site 862719012233 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 862719012234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 862719012235 HD domain; Region: HD_4; pfam13328 862719012236 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 862719012237 4Fe-4S binding domain; Region: Fer4_5; pfam12801 862719012238 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862719012239 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 862719012240 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9737855; Product type e : enzyme 862719012241 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 862719012242 PII uridylyl-transferase; Provisional; Region: PRK05092 862719012243 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 862719012244 metal binding triad; other site 862719012245 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 862719012246 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719012247 Zn2+ binding site [ion binding]; other site 862719012248 Mg2+ binding site [ion binding]; other site 862719012249 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 862719012250 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 862719012251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 862719012252 Transposase; Region: DEDD_Tnp_IS110; pfam01548 862719012253 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 862719012254 Uncharacterized conserved protein [Function unknown]; Region: COG1434 862719012255 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 862719012256 putative active site [active] 862719012257 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 862719012258 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 862719012259 Sporulation related domain; Region: SPOR; pfam05036 862719012260 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 862719012261 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 862719012262 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 862719012263 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 862719012264 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 862719012265 TMP-binding site; other site 862719012266 ATP-binding site [chemical binding]; other site 862719012267 DNA polymerase III subunit delta'; Validated; Region: PRK07471 862719012268 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 862719012269 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 862719012270 active site 862719012271 HIGH motif; other site 862719012272 KMSKS motif; other site 862719012273 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 862719012274 tRNA binding surface [nucleotide binding]; other site 862719012275 anticodon binding site; other site 862719012276 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 862719012277 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 862719012278 active site 862719012279 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 862719012280 putative hydrolase; Provisional; Region: PRK02113 862719012281 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 862719012282 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719012283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719012284 PAS fold; Region: PAS_3; pfam08447 862719012285 putative active site [active] 862719012286 heme pocket [chemical binding]; other site 862719012287 PAS fold; Region: PAS_3; pfam08447 862719012288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719012289 putative active site [active] 862719012290 heme pocket [chemical binding]; other site 862719012291 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719012292 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719012293 metal binding site [ion binding]; metal-binding site 862719012294 active site 862719012295 I-site; other site 862719012296 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719012297 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 862719012298 Recombination protein O N terminal; Region: RecO_N; pfam11967 862719012299 Recombination protein O C terminal; Region: RecO_C; pfam02565 862719012300 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 862719012301 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 862719012302 CAP-like domain; other site 862719012303 active site 862719012304 primary dimer interface [polypeptide binding]; other site 862719012305 Uncharacterized conserved protein [Function unknown]; Region: COG3334 862719012306 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 862719012307 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 862719012308 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 862719012309 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 862719012310 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 862719012311 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 862719012312 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 862719012313 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862719012314 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 862719012315 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 862719012316 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 862719012317 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12788 862719012318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719012319 non-specific DNA binding site [nucleotide binding]; other site 862719012320 salt bridge; other site 862719012321 sequence-specific DNA binding site [nucleotide binding]; other site 862719012322 Helix-turn-helix domain; Region: HTH_17; cl17695 862719012323 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719012324 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719012325 substrate binding pocket [chemical binding]; other site 862719012326 membrane-bound complex binding site; other site 862719012327 hinge residues; other site 862719012328 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 862719012329 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 862719012330 catalytic residue [active] 862719012331 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 862719012332 SPRY domain-like in bacteria; Region: SPRY_like; cd12886 862719012333 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 862719012334 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 862719012335 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 862719012336 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 862719012337 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 862719012338 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 862719012339 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 862719012340 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 862719012341 replicative DNA helicase; Provisional; Region: PRK09165 862719012342 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 862719012343 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 862719012344 Walker A motif; other site 862719012345 ATP binding site [chemical binding]; other site 862719012346 Walker B motif; other site 862719012347 Helix-turn-helix domain; Region: HTH_17; cl17695 862719012348 Protein of unknown function (DUF497); Region: DUF497; cl01108 862719012349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 862719012350 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 862719012351 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 862719012352 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719012353 active site 862719012354 DNA binding site [nucleotide binding] 862719012355 Int/Topo IB signature motif; other site 862719012356 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 862719012357 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 862719012358 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719012359 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 862719012360 flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787 862719012361 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 862719012362 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 862719012363 Rod binding protein; Region: Rod-binding; cl01626 862719012364 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 862719012365 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 862719012366 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 862719012367 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 862719012368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719012369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719012370 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 862719012371 putative active site [active] 862719012372 putative catalytic site [active] 862719012373 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 862719012374 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719012375 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 862719012376 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719012377 enoyl-CoA hydratase; Provisional; Region: PRK07511 862719012378 substrate binding site [chemical binding]; other site 862719012379 oxyanion hole (OAH) forming residues; other site 862719012380 trimer interface [polypeptide binding]; other site 862719012381 PAS fold; Region: PAS; pfam00989 862719012382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719012383 PAS domain; Region: PAS_9; pfam13426 862719012384 putative active site [active] 862719012385 heme pocket [chemical binding]; other site 862719012386 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719012387 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719012388 dimer interface [polypeptide binding]; other site 862719012389 putative CheW interface [polypeptide binding]; other site 862719012390 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 862719012391 DNA protecting protein DprA; Region: dprA; TIGR00732 862719012392 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 862719012393 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 862719012394 active site 862719012395 interdomain interaction site; other site 862719012396 putative metal-binding site [ion binding]; other site 862719012397 nucleotide binding site [chemical binding]; other site 862719012398 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 862719012399 domain I; other site 862719012400 DNA binding groove [nucleotide binding] 862719012401 phosphate binding site [ion binding]; other site 862719012402 domain II; other site 862719012403 domain III; other site 862719012404 nucleotide binding site [chemical binding]; other site 862719012405 catalytic site [active] 862719012406 domain IV; other site 862719012407 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 862719012408 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 862719012409 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 862719012410 enoyl-CoA hydratase; Validated; Region: PRK08139 862719012411 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719012412 substrate binding site [chemical binding]; other site 862719012413 oxyanion hole (OAH) forming residues; other site 862719012414 trimer interface [polypeptide binding]; other site 862719012415 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 862719012416 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 862719012417 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 862719012418 homodimer interface [polypeptide binding]; other site 862719012419 substrate-cofactor binding pocket; other site 862719012420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719012421 catalytic residue [active] 862719012422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 862719012423 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 862719012424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719012425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719012426 hypothetical protein; Provisional; Region: PRK09256 862719012427 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 862719012428 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 862719012429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012430 S-adenosylmethionine binding site [chemical binding]; other site 862719012431 Predicted membrane protein [Function unknown]; Region: COG4541 862719012432 AzlC protein; Region: AzlC; cl00570 862719012433 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 862719012434 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 862719012435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719012436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719012437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719012438 TPR motif; other site 862719012439 binding surface 862719012440 TPR repeat; Region: TPR_11; pfam13414 862719012441 TPR repeat; Region: TPR_11; pfam13414 862719012442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719012443 binding surface 862719012444 TPR motif; other site 862719012445 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 862719012446 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719012447 ATP binding site [chemical binding]; other site 862719012448 putative Mg++ binding site [ion binding]; other site 862719012449 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719012450 nucleotide binding region [chemical binding]; other site 862719012451 ATP-binding site [chemical binding]; other site 862719012452 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 862719012453 active site 862719012454 response regulator PleD; Reviewed; Region: pleD; PRK09581 862719012455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012456 active site 862719012457 phosphorylation site [posttranslational modification] 862719012458 intermolecular recognition site; other site 862719012459 dimerization interface [polypeptide binding]; other site 862719012460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012461 active site 862719012462 phosphorylation site [posttranslational modification] 862719012463 intermolecular recognition site; other site 862719012464 dimerization interface [polypeptide binding]; other site 862719012465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719012466 metal binding site [ion binding]; metal-binding site 862719012467 active site 862719012468 I-site; other site 862719012469 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719012470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012471 active site 862719012472 phosphorylation site [posttranslational modification] 862719012473 intermolecular recognition site; other site 862719012474 dimerization interface [polypeptide binding]; other site 862719012475 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719012476 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719012477 metal binding site [ion binding]; metal-binding site 862719012478 active site 862719012479 I-site; other site 862719012480 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 862719012481 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 862719012482 dimerization interface [polypeptide binding]; other site 862719012483 ligand binding site [chemical binding]; other site 862719012484 NADP binding site [chemical binding]; other site 862719012485 catalytic site [active] 862719012486 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 862719012487 recombination factor protein RarA; Reviewed; Region: PRK13342 862719012488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719012489 Walker A motif; other site 862719012490 ATP binding site [chemical binding]; other site 862719012491 Walker B motif; other site 862719012492 arginine finger; other site 862719012493 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 862719012494 Predicted membrane protein [Function unknown]; Region: COG1238 862719012495 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 862719012496 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 862719012497 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 862719012498 alphaNTD - beta interaction site [polypeptide binding]; other site 862719012499 alphaNTD homodimer interface [polypeptide binding]; other site 862719012500 alphaNTD - beta' interaction site [polypeptide binding]; other site 862719012501 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 862719012502 30S ribosomal protein S11; Validated; Region: PRK05309 862719012503 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 862719012504 30S ribosomal protein S13; Region: bact_S13; TIGR03631 862719012505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719012506 TPR motif; other site 862719012507 TPR repeat; Region: TPR_11; pfam13414 862719012508 binding surface 862719012509 elongation factor G; Reviewed; Region: PRK00007 862719012510 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 862719012511 G1 box; other site 862719012512 putative GEF interaction site [polypeptide binding]; other site 862719012513 GTP/Mg2+ binding site [chemical binding]; other site 862719012514 Switch I region; other site 862719012515 G2 box; other site 862719012516 G3 box; other site 862719012517 Switch II region; other site 862719012518 G4 box; other site 862719012519 G5 box; other site 862719012520 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 862719012521 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 862719012522 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 862719012523 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 862719012524 homotrimer interaction site [polypeptide binding]; other site 862719012525 putative active site [active] 862719012526 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 862719012527 active site 862719012528 DNA topoisomerase III; Provisional; Region: PRK07726 862719012529 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 862719012530 active site 862719012531 interdomain interaction site; other site 862719012532 putative metal-binding site [ion binding]; other site 862719012533 nucleotide binding site [chemical binding]; other site 862719012534 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 862719012535 domain I; other site 862719012536 DNA binding groove [nucleotide binding] 862719012537 phosphate binding site [ion binding]; other site 862719012538 domain II; other site 862719012539 domain III; other site 862719012540 nucleotide binding site [chemical binding]; other site 862719012541 catalytic site [active] 862719012542 domain IV; other site 862719012543 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862719012544 IHF dimer interface [polypeptide binding]; other site 862719012545 IHF - DNA interface [nucleotide binding]; other site 862719012546 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 862719012547 Found in ATP-dependent protease La (LON); Region: LON; smart00464 862719012548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719012549 Walker A motif; other site 862719012550 ATP binding site [chemical binding]; other site 862719012551 Walker B motif; other site 862719012552 arginine finger; other site 862719012553 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 862719012554 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 862719012555 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 862719012556 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 862719012557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719012558 Walker A motif; other site 862719012559 ATP binding site [chemical binding]; other site 862719012560 Walker B motif; other site 862719012561 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 862719012562 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 862719012563 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 862719012564 oligomer interface [polypeptide binding]; other site 862719012565 active site residues [active] 862719012566 trigger factor; Provisional; Region: tig; PRK01490 862719012567 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 862719012568 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 862719012569 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 862719012570 Uncharacterized conserved protein [Function unknown]; Region: COG0062 862719012571 putative carbohydrate kinase; Provisional; Region: PRK10565 862719012572 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 862719012573 putative substrate binding site [chemical binding]; other site 862719012574 putative ATP binding site [chemical binding]; other site 862719012575 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 862719012576 Nitrogen regulatory protein P-II; Region: P-II; smart00938 862719012577 glutamine synthetase; Provisional; Region: glnA; PRK09469 862719012578 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 862719012579 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 862719012580 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 862719012581 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 862719012582 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 862719012583 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 862719012584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719012585 Coenzyme A binding pocket [chemical binding]; other site 862719012586 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 862719012587 TPR repeat; Region: TPR_11; pfam13414 862719012588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719012589 binding surface 862719012590 TPR motif; other site 862719012591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719012592 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719012593 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 862719012594 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 862719012595 Stringent starvation protein B; Region: SspB; cl01120 862719012596 TfoX N-terminal domain; Region: TfoX_N; pfam04993 862719012597 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 862719012598 COQ9; Region: COQ9; pfam08511 862719012599 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 862719012600 active site 862719012601 catalytic residues [active] 862719012602 metal binding site [ion binding]; metal-binding site 862719012603 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 862719012604 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 862719012605 oligomerization interface [polypeptide binding]; other site 862719012606 active site 862719012607 metal binding site [ion binding]; metal-binding site 862719012608 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 862719012609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719012610 ATP binding site [chemical binding]; other site 862719012611 putative Mg++ binding site [ion binding]; other site 862719012612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719012613 nucleotide binding region [chemical binding]; other site 862719012614 ATP-binding site [chemical binding]; other site 862719012615 DEAD/H associated; Region: DEAD_assoc; pfam08494 862719012616 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 862719012617 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719012618 catalytic loop [active] 862719012619 iron binding site [ion binding]; other site 862719012620 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 862719012621 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 862719012622 putative active site [active] 862719012623 putative metal binding site [ion binding]; other site 862719012624 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 862719012625 DNA photolyase; Region: DNA_photolyase; pfam00875 862719012626 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 862719012627 metal binding site 2 [ion binding]; metal-binding site 862719012628 putative DNA binding helix; other site 862719012629 metal binding site 1 [ion binding]; metal-binding site 862719012630 dimer interface [polypeptide binding]; other site 862719012631 structural Zn2+ binding site [ion binding]; other site 862719012632 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 862719012633 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 862719012634 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 862719012635 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 862719012636 Zn binding site [ion binding]; other site 862719012637 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719012638 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719012639 dimer interface [polypeptide binding]; other site 862719012640 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719012641 putative CheW interface [polypeptide binding]; other site 862719012642 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 862719012643 putative active site pocket [active] 862719012644 dimerization interface [polypeptide binding]; other site 862719012645 putative catalytic residue [active] 862719012646 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 862719012647 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 862719012648 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 862719012649 putative dimer interface [polypeptide binding]; other site 862719012650 putative active site [active] 862719012651 Response regulator receiver domain; Region: Response_reg; pfam00072 862719012652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012653 active site 862719012654 phosphorylation site [posttranslational modification] 862719012655 intermolecular recognition site; other site 862719012656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719012657 dimerization interface [polypeptide binding]; other site 862719012658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719012659 dimer interface [polypeptide binding]; other site 862719012660 phosphorylation site [posttranslational modification] 862719012661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012662 ATP binding site [chemical binding]; other site 862719012663 Mg2+ binding site [ion binding]; other site 862719012664 G-X-G motif; other site 862719012665 DNA polymerase III subunit chi; Validated; Region: PRK05728 862719012666 multifunctional aminopeptidase A; Provisional; Region: PRK00913 862719012667 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 862719012668 interface (dimer of trimers) [polypeptide binding]; other site 862719012669 Substrate-binding/catalytic site; other site 862719012670 Zn-binding sites [ion binding]; other site 862719012671 ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563 862719012672 FtsJ-like methyltransferase; Region: FtsJ; cl17430 862719012673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012674 S-adenosylmethionine binding site [chemical binding]; other site 862719012675 MltA specific insert domain; Region: MltA; smart00925 862719012676 3D domain; Region: 3D; pfam06725 862719012677 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 862719012678 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 862719012679 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 862719012680 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 862719012681 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 862719012682 Walker A/P-loop; other site 862719012683 ATP binding site [chemical binding]; other site 862719012684 Q-loop/lid; other site 862719012685 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 862719012686 Q-loop/lid; other site 862719012687 ABC transporter signature motif; other site 862719012688 Walker B; other site 862719012689 D-loop; other site 862719012690 H-loop/switch region; other site 862719012691 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 862719012692 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 862719012693 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 862719012694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012695 active site 862719012696 phosphorylation site [posttranslational modification] 862719012697 intermolecular recognition site; other site 862719012698 dimerization interface [polypeptide binding]; other site 862719012699 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 862719012700 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 862719012701 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 862719012702 active site 862719012703 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 862719012704 putative metal binding site [ion binding]; other site 862719012705 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 862719012706 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 862719012707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012708 S-adenosylmethionine binding site [chemical binding]; other site 862719012709 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 862719012710 Part of AAA domain; Region: AAA_19; pfam13245 862719012711 Family description; Region: UvrD_C_2; pfam13538 862719012712 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719012713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012714 active site 862719012715 phosphorylation site [posttranslational modification] 862719012716 intermolecular recognition site; other site 862719012717 dimerization interface [polypeptide binding]; other site 862719012718 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719012719 DNA binding residues [nucleotide binding] 862719012720 dimerization interface [polypeptide binding]; other site 862719012721 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719012722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719012723 active site 862719012724 phosphorylation site [posttranslational modification] 862719012725 intermolecular recognition site; other site 862719012726 dimerization interface [polypeptide binding]; other site 862719012727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719012728 DNA binding residues [nucleotide binding] 862719012729 dimerization interface [polypeptide binding]; other site 862719012730 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719012731 hypothetical protein; Provisional; Region: PRK11770 862719012732 Domain of unknown function (DUF307); Region: DUF307; pfam03733 862719012733 Domain of unknown function (DUF307); Region: DUF307; pfam03733 862719012734 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 862719012735 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 862719012736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012737 ATP binding site [chemical binding]; other site 862719012738 Mg2+ binding site [ion binding]; other site 862719012739 G-X-G motif; other site 862719012740 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 862719012741 ATP binding site [chemical binding]; other site 862719012742 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 862719012743 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 862719012744 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 862719012745 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 862719012746 NADH(P)-binding; Region: NAD_binding_10; pfam13460 862719012747 NAD binding site [chemical binding]; other site 862719012748 putative active site [active] 862719012749 substrate binding site [chemical binding]; other site 862719012750 Predicted transcriptional regulators [Transcription]; Region: COG1733 862719012751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719012752 dimerization interface [polypeptide binding]; other site 862719012753 putative DNA binding site [nucleotide binding]; other site 862719012754 putative Zn2+ binding site [ion binding]; other site 862719012755 trehalose synthase; Region: treS_nterm; TIGR02456 862719012756 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 862719012757 active site 862719012758 catalytic site [active] 862719012759 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 862719012760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719012761 putative substrate translocation pore; other site 862719012762 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 862719012763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719012764 S-adenosylmethionine binding site [chemical binding]; other site 862719012765 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 862719012766 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862719012767 RNA binding surface [nucleotide binding]; other site 862719012768 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 862719012769 active site 862719012770 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 862719012771 nucleoside/Zn binding site; other site 862719012772 dimer interface [polypeptide binding]; other site 862719012773 catalytic motif [active] 862719012774 PAS fold; Region: PAS_3; pfam08447 862719012775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719012776 putative active site [active] 862719012777 heme pocket [chemical binding]; other site 862719012778 PAS fold; Region: PAS_3; pfam08447 862719012779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719012780 putative active site [active] 862719012781 heme pocket [chemical binding]; other site 862719012782 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719012783 dimer interface [polypeptide binding]; other site 862719012784 putative CheW interface [polypeptide binding]; other site 862719012785 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 862719012786 active site 862719012787 NTP binding site [chemical binding]; other site 862719012788 metal binding triad [ion binding]; metal-binding site 862719012789 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 862719012790 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 862719012791 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 862719012792 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 862719012793 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 862719012794 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 862719012795 generic binding surface II; other site 862719012796 generic binding surface I; other site 862719012797 tricarballylate dehydrogenase; Validated; Region: PRK08274 862719012798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862719012799 tricarballylate utilization protein B; Provisional; Region: PRK15033 862719012800 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 862719012801 active site 862719012802 substrate binding pocket [chemical binding]; other site 862719012803 dimer interface [polypeptide binding]; other site 862719012804 histidyl-tRNA synthetase; Region: hisS; TIGR00442 862719012805 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 862719012806 dimer interface [polypeptide binding]; other site 862719012807 motif 1; other site 862719012808 active site 862719012809 motif 2; other site 862719012810 motif 3; other site 862719012811 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 862719012812 anticodon binding site; other site 862719012813 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 862719012814 Transglycosylase; Region: Transgly; cl17702 862719012815 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 862719012816 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 862719012817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719012818 NAD(P) binding site [chemical binding]; other site 862719012819 active site 862719012820 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 862719012821 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 862719012822 5S rRNA interface [nucleotide binding]; other site 862719012823 CTC domain interface [polypeptide binding]; other site 862719012824 L16 interface [polypeptide binding]; other site 862719012825 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 862719012826 putative active site [active] 862719012827 catalytic residue [active] 862719012828 GTP-binding protein YchF; Reviewed; Region: PRK09601 862719012829 YchF GTPase; Region: YchF; cd01900 862719012830 G1 box; other site 862719012831 GTP/Mg2+ binding site [chemical binding]; other site 862719012832 Switch I region; other site 862719012833 G2 box; other site 862719012834 Switch II region; other site 862719012835 G3 box; other site 862719012836 G4 box; other site 862719012837 G5 box; other site 862719012838 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 862719012839 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 862719012840 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 862719012841 PhoU domain; Region: PhoU; pfam01895 862719012842 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1689546, 17322315, 15289546; Product type pe : putative enzyme 862719012843 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 862719012844 nudix motif; other site 862719012845 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719012846 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719012847 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719012848 dimerization interface [polypeptide binding]; other site 862719012849 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719012850 NADH dehydrogenase; Validated; Region: PRK08183 862719012851 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 862719012852 mce related protein; Region: MCE; pfam02470 862719012853 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 862719012854 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 862719012855 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 862719012856 serine O-acetyltransferase; Region: cysE; TIGR01172 862719012857 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 862719012858 trimer interface [polypeptide binding]; other site 862719012859 active site 862719012860 substrate binding site [chemical binding]; other site 862719012861 CoA binding site [chemical binding]; other site 862719012862 Transcriptional regulator; Region: Rrf2; cl17282 862719012863 Rrf2 family protein; Region: rrf2_super; TIGR00738 862719012864 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719012865 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 862719012866 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719012867 catalytic residue [active] 862719012868 co-chaperone HscB; Provisional; Region: hscB; PRK05014 862719012869 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 862719012870 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719012871 catalytic loop [active] 862719012872 iron binding site [ion binding]; other site 862719012873 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 862719012874 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 862719012875 Ligand Binding Site [chemical binding]; other site 862719012876 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 862719012877 active site 862719012878 catalytic triad [active] 862719012879 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862719012880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719012881 Walker A motif; other site 862719012882 ATP binding site [chemical binding]; other site 862719012883 Walker B motif; other site 862719012884 arginine finger; other site 862719012885 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 862719012886 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 862719012887 ParB-like nuclease domain; Region: ParBc; pfam02195 862719012888 Methyltransferase domain; Region: Methyltransf_26; pfam13659 862719012889 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 862719012890 Helicase_C-like; Region: Helicase_C_4; pfam13871 862719012891 Toprim domain; Region: Toprim_3; pfam13362 862719012892 active site 862719012893 metal binding site [ion binding]; metal-binding site 862719012894 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 862719012895 Protein of unknown function (DUF736); Region: DUF736; pfam05284 862719012896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719012897 non-specific DNA binding site [nucleotide binding]; other site 862719012898 salt bridge; other site 862719012899 sequence-specific DNA binding site [nucleotide binding]; other site 862719012900 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719012901 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719012902 sequence-specific DNA binding site [nucleotide binding]; other site 862719012903 salt bridge; other site 862719012904 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 862719012905 Evidence 7 : Gene remnant; Product type e : enzyme 862719012906 Evidence 7 : Gene remnant; Product type e : enzyme 862719012907 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719012908 Part of AAA domain; Region: AAA_19; pfam13245 862719012909 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 862719012910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 862719012911 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 862719012912 CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113 862719012913 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 862719012914 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 862719012915 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 862719012916 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 862719012917 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 862719012918 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 862719012919 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719012920 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719012921 Helix-turn-helix domain; Region: HTH_17; pfam12728 862719012922 Replication initiator protein A; Region: RPA; pfam10134 862719012923 ParA-like protein; Provisional; Region: PHA02518 862719012924 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719012925 P-loop; other site 862719012926 Magnesium ion binding site [ion binding]; other site 862719012927 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 862719012928 Evidence 2b : Function of strongly homologous gene; PubMedId : 11976307; Product type f : factor 862719012929 Evidence 2b : Function of strongly homologous gene; PubMedId : 11976307; Product type f : factor 862719012930 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 862719012931 Type II/IV secretion system protein; Region: T2SE; pfam00437 862719012932 Walker A motif; other site 862719012933 ATP binding site [chemical binding]; other site 862719012934 Walker B motif; other site 862719012935 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 862719012936 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 862719012937 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 862719012938 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 862719012939 VirB7 interaction site; other site 862719012940 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 862719012941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719012942 ATP binding site [chemical binding]; other site 862719012943 Mg2+ binding site [ion binding]; other site 862719012944 G-X-G motif; other site 862719012945 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 862719012946 TIGR01210 family protein; Region: TIGR01210 862719012947 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 862719012948 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 862719012949 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 862719012950 HTH-like domain; Region: HTH_21; pfam13276 862719012951 Integrase core domain; Region: rve; pfam00665 862719012952 Integrase core domain; Region: rve_3; pfam13683 862719012953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 862719012954 Transposase; Region: HTH_Tnp_1; cl17663 862719012955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719012956 binding surface 862719012957 TPR motif; other site 862719012958 TPR repeat; Region: TPR_11; pfam13414 862719012959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719012960 binding surface 862719012961 TPR motif; other site 862719012962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719012963 AAA domain; Region: AAA_23; pfam13476 862719012964 Walker A/P-loop; other site 862719012965 ATP binding site [chemical binding]; other site 862719012966 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 862719012967 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719012968 ATP binding site [chemical binding]; other site 862719012969 putative Mg++ binding site [ion binding]; other site 862719012970 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 862719012971 nucleotide binding region [chemical binding]; other site 862719012972 ATP-binding site [chemical binding]; other site 862719012973 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 862719012974 HsdM N-terminal domain; Region: HsdM_N; pfam12161 862719012975 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 862719012976 Methyltransferase domain; Region: Methyltransf_26; pfam13659 862719012977 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 862719012978 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 862719012979 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862719012980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719012981 FeS/SAM binding site; other site 862719012982 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 862719012983 Ferritin-like; Region: Ferritin-like; pfam12902 862719012984 integrase; Provisional; Region: PRK09692 862719012985 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 862719012986 active site 862719012987 Int/Topo IB signature motif; other site 862719012988 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 862719012989 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 862719012990 catalytic residues [active] 862719012991 catalytic nucleophile [active] 862719012992 Recombinase; Region: Recombinase; pfam07508 862719012993 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 862719012994 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719012995 Winged helix-turn helix; Region: HTH_29; pfam13551 862719012996 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719012997 Winged helix-turn helix; Region: HTH_33; pfam13592 862719012998 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 862719012999 catalytic residues [active] 862719013000 catalytic nucleophile [active] 862719013001 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 862719013002 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 862719013003 Protein of unknown function DUF262; Region: DUF262; pfam03235 862719013004 Uncharacterized conserved protein [Function unknown]; Region: COG1479 862719013005 Uncharacterized conserved protein [Function unknown]; Region: COG3472 862719013006 DNA methylase; Region: N6_N4_Mtase; cl17433 862719013007 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 862719013008 EcsC protein family; Region: EcsC; pfam12787 862719013009 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 862719013010 Part of AAA domain; Region: AAA_19; pfam13245 862719013011 Family description; Region: UvrD_C_2; pfam13538 862719013012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 862719013013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719013014 Walker B motif; other site 862719013015 arginine finger; other site 862719013016 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862719013017 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719013018 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719013019 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719013020 short chain dehydrogenase; Provisional; Region: PRK06179 862719013021 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 862719013022 NADP binding site [chemical binding]; other site 862719013023 active site 862719013024 steroid binding site; other site 862719013025 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 862719013026 putative efflux protein, MATE family; Region: matE; TIGR00797 862719013027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719013028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719013029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719013030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719013031 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719013032 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719013033 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013035 active site 862719013036 phosphorylation site [posttranslational modification] 862719013037 intermolecular recognition site; other site 862719013038 dimerization interface [polypeptide binding]; other site 862719013039 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719013040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719013041 metal binding site [ion binding]; metal-binding site 862719013042 active site 862719013043 I-site; other site 862719013044 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 862719013045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719013046 Walker A motif; other site 862719013047 ATP binding site [chemical binding]; other site 862719013048 Walker B motif; other site 862719013049 arginine finger; other site 862719013050 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719013051 5-oxoprolinase; Region: PLN02666 862719013052 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 862719013053 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 862719013054 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 862719013055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719013056 Coenzyme A binding pocket [chemical binding]; other site 862719013057 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 862719013058 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 862719013059 putative metal binding site [ion binding]; other site 862719013060 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 862719013061 HSP70 interaction site [polypeptide binding]; other site 862719013062 ABC transporter ATPase component; Reviewed; Region: PRK11147 862719013063 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862719013064 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 862719013065 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 862719013066 EamA-like transporter family; Region: EamA; pfam00892 862719013067 EamA-like transporter family; Region: EamA; pfam00892 862719013068 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 862719013069 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 862719013070 amidase catalytic site [active] 862719013071 Zn binding residues [ion binding]; other site 862719013072 substrate binding site [chemical binding]; other site 862719013073 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 862719013074 putative active site [active] 862719013075 cell division protein MraZ; Reviewed; Region: PRK00326 862719013076 MraZ protein; Region: MraZ; pfam02381 862719013077 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 862719013078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719013079 S-adenosylmethionine binding site [chemical binding]; other site 862719013080 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 862719013081 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 862719013082 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 862719013083 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 862719013084 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 862719013085 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 862719013086 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862719013087 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862719013088 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 862719013089 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 862719013090 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862719013091 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862719013092 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 862719013093 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 862719013094 Mg++ binding site [ion binding]; other site 862719013095 putative catalytic motif [active] 862719013096 putative substrate binding site [chemical binding]; other site 862719013097 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 862719013098 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 862719013099 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862719013100 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862719013101 cell division protein FtsW; Region: ftsW; TIGR02614 862719013102 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 862719013103 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 862719013104 active site 862719013105 homodimer interface [polypeptide binding]; other site 862719013106 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 862719013107 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 862719013108 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862719013109 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 862719013110 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 862719013111 FAD binding domain; Region: FAD_binding_4; pfam01565 862719013112 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 862719013113 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 862719013114 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 862719013115 ATP-grasp domain; Region: ATP-grasp_4; cl17255 862719013116 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 862719013117 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 862719013118 Cell division protein FtsQ; Region: FtsQ; pfam03799 862719013119 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 862719013120 Cell division protein FtsA; Region: FtsA; smart00842 862719013121 Cell division protein FtsA; Region: FtsA; pfam14450 862719013122 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 862719013123 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 862719013124 nucleotide binding site [chemical binding]; other site 862719013125 SulA interaction site; other site 862719013126 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 862719013127 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 862719013128 Hemerythrin; Region: Hemerythrin; cd12107 862719013129 Fe binding site [ion binding]; other site 862719013130 Ligase N family; Region: LIGANc; smart00532 862719013131 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 862719013132 nucleotide binding pocket [chemical binding]; other site 862719013133 K-X-D-G motif; other site 862719013134 catalytic site [active] 862719013135 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 862719013136 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 862719013137 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 862719013138 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 862719013139 Dimer interface [polypeptide binding]; other site 862719013140 BRCT sequence motif; other site 862719013141 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 862719013142 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 862719013143 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 862719013144 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 862719013145 active site 862719013146 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 862719013147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719013148 S-adenosylmethionine binding site [chemical binding]; other site 862719013149 exopolyphosphatase; Region: exo_poly_only; TIGR03706 862719013150 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 862719013151 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 862719013152 ABC1 family; Region: ABC1; pfam03109 862719013153 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 862719013154 active site 862719013155 ATP binding site [chemical binding]; other site 862719013156 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 862719013157 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 862719013158 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 862719013159 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 862719013160 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 862719013161 epoxyqueuosine reductase; Region: TIGR00276 862719013162 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 862719013163 Sterol carrier protein domain; Region: SCP2_2; pfam13530 862719013164 HAMP domain; Region: HAMP; pfam00672 862719013165 dimerization interface [polypeptide binding]; other site 862719013166 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719013167 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719013168 dimer interface [polypeptide binding]; other site 862719013169 putative CheW interface [polypeptide binding]; other site 862719013170 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 862719013171 putative active site [active] 862719013172 putative metal binding residues [ion binding]; other site 862719013173 signature motif; other site 862719013174 putative dimer interface [polypeptide binding]; other site 862719013175 putative phosphate binding site [ion binding]; other site 862719013176 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 862719013177 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 862719013178 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 862719013179 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 862719013180 Domain of unknown function DUF29; Region: DUF29; pfam01724 862719013181 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 862719013182 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 862719013183 putative ligand binding site [chemical binding]; other site 862719013184 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719013185 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719013186 TM-ABC transporter signature motif; other site 862719013187 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719013188 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 862719013189 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 862719013190 TM-ABC transporter signature motif; other site 862719013191 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 862719013192 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 862719013193 Walker A/P-loop; other site 862719013194 ATP binding site [chemical binding]; other site 862719013195 Q-loop/lid; other site 862719013196 ABC transporter signature motif; other site 862719013197 Walker B; other site 862719013198 D-loop; other site 862719013199 H-loop/switch region; other site 862719013200 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 862719013201 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 862719013202 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 862719013203 PRC-barrel domain; Region: PRC; pfam05239 862719013204 ATP12 chaperone protein; Region: ATP12; cl02228 862719013205 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 862719013206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719013207 motif II; other site 862719013208 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 862719013209 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 862719013210 RNA binding surface [nucleotide binding]; other site 862719013211 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 862719013212 active site 862719013213 CrcB-like protein; Region: CRCB; cl09114 862719013214 Isochorismatase family; Region: Isochorismatase; pfam00857 862719013215 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 862719013216 catalytic triad [active] 862719013217 conserved cis-peptide bond; other site 862719013218 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 862719013219 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 862719013220 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 862719013221 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 862719013222 Walker A/P-loop; other site 862719013223 ATP binding site [chemical binding]; other site 862719013224 Q-loop/lid; other site 862719013225 ABC transporter signature motif; other site 862719013226 Walker B; other site 862719013227 D-loop; other site 862719013228 H-loop/switch region; other site 862719013229 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 862719013230 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 862719013231 FtsX-like permease family; Region: FtsX; pfam02687 862719013232 prolyl-tRNA synthetase; Provisional; Region: PRK12325 862719013233 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 862719013234 dimer interface [polypeptide binding]; other site 862719013235 motif 1; other site 862719013236 active site 862719013237 motif 2; other site 862719013238 motif 3; other site 862719013239 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 862719013240 anticodon binding site; other site 862719013241 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 862719013242 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 862719013243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719013244 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 862719013245 dimer interface [polypeptide binding]; other site 862719013246 substrate binding site [chemical binding]; other site 862719013247 metal binding site [ion binding]; metal-binding site 862719013248 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 862719013249 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 862719013250 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 862719013251 pantothenate kinase; Reviewed; Region: PRK13318 862719013252 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 862719013253 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 862719013254 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 862719013255 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 862719013256 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719013257 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 862719013258 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719013259 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 862719013260 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 862719013261 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719013262 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 862719013263 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 862719013264 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 862719013265 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 862719013266 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 862719013267 4Fe-4S binding domain; Region: Fer4; pfam00037 862719013268 4Fe-4S binding domain; Region: Fer4; pfam00037 862719013269 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 862719013270 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 862719013271 NADH dehydrogenase subunit G; Validated; Region: PRK09130 862719013272 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719013273 catalytic loop [active] 862719013274 iron binding site [ion binding]; other site 862719013275 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 862719013276 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 862719013277 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 862719013278 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 862719013279 SLBB domain; Region: SLBB; pfam10531 862719013280 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 862719013281 NADH dehydrogenase subunit E; Validated; Region: PRK07539 862719013282 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 862719013283 putative dimer interface [polypeptide binding]; other site 862719013284 [2Fe-2S] cluster binding site [ion binding]; other site 862719013285 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 862719013286 NADH dehydrogenase subunit D; Validated; Region: PRK06075 862719013287 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 862719013288 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 862719013289 NADH dehydrogenase subunit B; Validated; Region: PRK06411 862719013290 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 862719013291 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 862719013292 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 862719013293 catalytic residues [active] 862719013294 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 862719013295 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 862719013296 acyl-activating enzyme (AAE) consensus motif; other site 862719013297 putative AMP binding site [chemical binding]; other site 862719013298 putative active site [active] 862719013299 putative CoA binding site [chemical binding]; other site 862719013300 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 862719013301 Lysine efflux permease [General function prediction only]; Region: COG1279 862719013302 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 862719013303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719013304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719013305 dimerization interface [polypeptide binding]; other site 862719013306 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 862719013307 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 862719013308 active site 862719013309 Zn binding site [ion binding]; other site 862719013310 Hemerythrin; Region: Hemerythrin; cd12107 862719013311 Fe binding site [ion binding]; other site 862719013312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719013313 S-adenosylmethionine binding site [chemical binding]; other site 862719013314 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 862719013315 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 862719013316 metal binding site [ion binding]; metal-binding site 862719013317 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 862719013318 PhoU domain; Region: PhoU; pfam01895 862719013319 PhoU domain; Region: PhoU; pfam01895 862719013320 hypothetical protein; Provisional; Region: PRK05208 862719013321 rod shape-determining protein MreB; Provisional; Region: PRK13927 862719013322 MreB and similar proteins; Region: MreB_like; cd10225 862719013323 nucleotide binding site [chemical binding]; other site 862719013324 Mg binding site [ion binding]; other site 862719013325 putative protofilament interaction site [polypeptide binding]; other site 862719013326 RodZ interaction site [polypeptide binding]; other site 862719013327 rod shape-determining protein MreC; Provisional; Region: PRK13922 862719013328 rod shape-determining protein MreC; Region: MreC; pfam04085 862719013329 rod shape-determining protein MreD; Region: MreD; cl01087 862719013330 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 862719013331 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 862719013332 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 862719013333 ketol-acid reductoisomerase; Provisional; Region: PRK05479 862719013334 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 862719013335 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 862719013336 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 862719013337 putative active site [active] 862719013338 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 862719013339 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 862719013340 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 862719013341 putative valine binding site [chemical binding]; other site 862719013342 dimer interface [polypeptide binding]; other site 862719013343 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 862719013344 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 862719013345 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 862719013346 PYR/PP interface [polypeptide binding]; other site 862719013347 dimer interface [polypeptide binding]; other site 862719013348 TPP binding site [chemical binding]; other site 862719013349 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 862719013350 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 862719013351 TPP-binding site [chemical binding]; other site 862719013352 dimer interface [polypeptide binding]; other site 862719013353 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 862719013354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719013355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719013356 homodimer interface [polypeptide binding]; other site 862719013357 catalytic residue [active] 862719013358 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 862719013359 IPP transferase; Region: IPPT; pfam01715 862719013360 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 862719013361 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 862719013362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719013363 motif II; other site 862719013364 Hemerythrin; Region: Hemerythrin; cd12107 862719013365 Fe binding site [ion binding]; other site 862719013366 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 862719013367 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 862719013368 NAD binding site [chemical binding]; other site 862719013369 homotetramer interface [polypeptide binding]; other site 862719013370 homodimer interface [polypeptide binding]; other site 862719013371 substrate binding site [chemical binding]; other site 862719013372 active site 862719013373 PRC-barrel domain; Region: PRC; pfam05239 862719013374 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 862719013375 G1 box; other site 862719013376 GTP/Mg2+ binding site [chemical binding]; other site 862719013377 G2 box; other site 862719013378 Switch I region; other site 862719013379 G3 box; other site 862719013380 Switch II region; other site 862719013381 G4 box; other site 862719013382 G5 box; other site 862719013383 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 862719013384 UreF; Region: UreF; pfam01730 862719013385 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 862719013386 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 862719013387 dimer interface [polypeptide binding]; other site 862719013388 catalytic residues [active] 862719013389 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 862719013390 urease subunit alpha; Reviewed; Region: ureC; PRK13207 862719013391 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 862719013392 subunit interactions [polypeptide binding]; other site 862719013393 active site 862719013394 flap region; other site 862719013395 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 862719013396 gamma-beta subunit interface [polypeptide binding]; other site 862719013397 alpha-beta subunit interface [polypeptide binding]; other site 862719013398 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 862719013399 alpha-gamma subunit interface [polypeptide binding]; other site 862719013400 beta-gamma subunit interface [polypeptide binding]; other site 862719013401 UreD urease accessory protein; Region: UreD; pfam01774 862719013402 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719013403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013404 active site 862719013405 phosphorylation site [posttranslational modification] 862719013406 intermolecular recognition site; other site 862719013407 dimerization interface [polypeptide binding]; other site 862719013408 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719013409 DNA binding residues [nucleotide binding] 862719013410 dimerization interface [polypeptide binding]; other site 862719013411 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719013412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 862719013413 active site 862719013414 phosphorylation site [posttranslational modification] 862719013415 intermolecular recognition site; other site 862719013416 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719013417 DNA binding residues [nucleotide binding] 862719013418 dimerization interface [polypeptide binding]; other site 862719013419 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 862719013420 intracellular protease, PfpI family; Region: PfpI; TIGR01382 862719013421 proposed catalytic triad [active] 862719013422 conserved cys residue [active] 862719013423 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 862719013424 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 862719013425 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 862719013426 hinge; other site 862719013427 active site 862719013428 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 862719013429 trimer interface [polypeptide binding]; other site 862719013430 active site 862719013431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719013432 Coenzyme A binding pocket [chemical binding]; other site 862719013433 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719013434 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 862719013435 putative NAD(P) binding site [chemical binding]; other site 862719013436 active site 862719013437 putative substrate binding site [chemical binding]; other site 862719013438 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 862719013439 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 862719013440 Mg++ binding site [ion binding]; other site 862719013441 putative catalytic motif [active] 862719013442 putative substrate binding site [chemical binding]; other site 862719013443 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 862719013444 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 862719013445 Probable Catalytic site; other site 862719013446 metal-binding site 862719013447 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 862719013448 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 862719013449 Probable Catalytic site; other site 862719013450 metal-binding site 862719013451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719013452 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 862719013453 putative NAD(P) binding site [chemical binding]; other site 862719013454 active site 862719013455 putative substrate binding site [chemical binding]; other site 862719013456 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 862719013457 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 862719013458 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 862719013459 NAD(P) binding site [chemical binding]; other site 862719013460 homodimer interface [polypeptide binding]; other site 862719013461 substrate binding site [chemical binding]; other site 862719013462 active site 862719013463 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 862719013464 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 862719013465 Tetramer interface [polypeptide binding]; other site 862719013466 active site 862719013467 FMN-binding site [chemical binding]; other site 862719013468 ribonuclease R; Region: RNase_R; TIGR02063 862719013469 RNB domain; Region: RNB; pfam00773 862719013470 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 862719013471 RNA binding site [nucleotide binding]; other site 862719013472 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 862719013473 protein binding site [polypeptide binding]; other site 862719013474 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 862719013475 Catalytic dyad [active] 862719013476 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 862719013477 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 862719013478 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 862719013479 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 862719013480 LrgA family; Region: LrgA; pfam03788 862719013481 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 862719013482 2-isopropylmalate synthase; Validated; Region: PRK03739 862719013483 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 862719013484 active site 862719013485 catalytic residues [active] 862719013486 metal binding site [ion binding]; metal-binding site 862719013487 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 862719013488 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 862719013489 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 862719013490 NADP binding site [chemical binding]; other site 862719013491 homopentamer interface [polypeptide binding]; other site 862719013492 substrate binding site [chemical binding]; other site 862719013493 active site 862719013494 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 862719013495 Uncharacterized conserved protein [Function unknown]; Region: COG1565 862719013496 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 862719013497 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 862719013498 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 862719013499 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 862719013500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719013501 active site 862719013502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719013503 sequence-specific DNA binding site [nucleotide binding]; other site 862719013504 salt bridge; other site 862719013505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719013506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719013507 non-specific DNA binding site [nucleotide binding]; other site 862719013508 salt bridge; other site 862719013509 sequence-specific DNA binding site [nucleotide binding]; other site 862719013510 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 862719013511 Catalytic site [active] 862719013512 Uncharacterized conserved protein [Function unknown]; Region: COG2128 862719013513 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 862719013514 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 862719013515 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719013516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719013517 dimer interface [polypeptide binding]; other site 862719013518 phosphorylation site [posttranslational modification] 862719013519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013520 ATP binding site [chemical binding]; other site 862719013521 Mg2+ binding site [ion binding]; other site 862719013522 G-X-G motif; other site 862719013523 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013525 active site 862719013526 phosphorylation site [posttranslational modification] 862719013527 intermolecular recognition site; other site 862719013528 dimerization interface [polypeptide binding]; other site 862719013529 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862719013530 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 862719013531 Walker A/P-loop; other site 862719013532 ATP binding site [chemical binding]; other site 862719013533 Q-loop/lid; other site 862719013534 ABC transporter signature motif; other site 862719013535 Walker B; other site 862719013536 D-loop; other site 862719013537 H-loop/switch region; other site 862719013538 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719013539 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 862719013540 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719013541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719013542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719013543 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862719013544 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 862719013545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719013546 Walker A motif; other site 862719013547 ATP binding site [chemical binding]; other site 862719013548 Walker B motif; other site 862719013549 arginine finger; other site 862719013550 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719013551 cyclase homology domain; Region: CHD; cd07302 862719013552 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 862719013553 nucleotidyl binding site; other site 862719013554 metal binding site [ion binding]; metal-binding site 862719013555 dimer interface [polypeptide binding]; other site 862719013556 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862719013557 phosphopeptide binding site; other site 862719013558 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 862719013559 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719013560 FeS/SAM binding site; other site 862719013561 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 862719013562 hypothetical protein; Provisional; Region: PRK13795 862719013563 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 862719013564 NifZ domain; Region: NifZ; pfam04319 862719013565 NifZ domain; Region: NifZ; pfam04319 862719013566 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 862719013567 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 862719013568 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719013569 catalytic residue [active] 862719013570 NifT/FixU protein; Region: NifT; pfam06988 862719013571 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 862719013572 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 862719013573 inhibitor-cofactor binding pocket; inhibition site 862719013574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719013575 catalytic residue [active] 862719013576 SIR2-like domain; Region: SIR2_2; pfam13289 862719013577 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 862719013578 intracellular septation protein A; Reviewed; Region: PRK00259 862719013579 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 862719013580 Sporulation related domain; Region: SPOR; pfam05036 862719013581 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013583 active site 862719013584 phosphorylation site [posttranslational modification] 862719013585 intermolecular recognition site; other site 862719013586 dimerization interface [polypeptide binding]; other site 862719013587 PAS fold; Region: PAS; pfam00989 862719013588 PAS domain; Region: PAS; smart00091 862719013589 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 862719013590 active site 862719013591 catalytic site [active] 862719013592 substrate binding site [chemical binding]; other site 862719013593 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 862719013594 Na binding site [ion binding]; other site 862719013595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719013596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719013597 dimer interface [polypeptide binding]; other site 862719013598 phosphorylation site [posttranslational modification] 862719013599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013600 ATP binding site [chemical binding]; other site 862719013601 Mg2+ binding site [ion binding]; other site 862719013602 G-X-G motif; other site 862719013603 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013605 active site 862719013606 phosphorylation site [posttranslational modification] 862719013607 intermolecular recognition site; other site 862719013608 dimerization interface [polypeptide binding]; other site 862719013609 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719013610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719013611 putative active site [active] 862719013612 heme pocket [chemical binding]; other site 862719013613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013614 ATP binding site [chemical binding]; other site 862719013615 Mg2+ binding site [ion binding]; other site 862719013616 G-X-G motif; other site 862719013617 PAS domain; Region: PAS_9; pfam13426 862719013618 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 862719013619 PAS fold; Region: PAS_7; pfam12860 862719013620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719013621 dimer interface [polypeptide binding]; other site 862719013622 phosphorylation site [posttranslational modification] 862719013623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013624 ATP binding site [chemical binding]; other site 862719013625 Mg2+ binding site [ion binding]; other site 862719013626 G-X-G motif; other site 862719013627 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013629 active site 862719013630 phosphorylation site [posttranslational modification] 862719013631 intermolecular recognition site; other site 862719013632 dimerization interface [polypeptide binding]; other site 862719013633 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 862719013634 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862719013635 active site residue [active] 862719013636 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 862719013637 ATP binding site [chemical binding]; other site 862719013638 substrate interface [chemical binding]; other site 862719013639 Uncharacterized conserved protein [Function unknown]; Region: COG3482 862719013640 Uncharacterized conserved protein [Function unknown]; Region: COG1944 862719013641 YcaO-like family; Region: YcaO; pfam02624 862719013642 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 862719013643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 862719013644 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 862719013645 dimer interface [polypeptide binding]; other site 862719013646 motif 1; other site 862719013647 active site 862719013648 motif 2; other site 862719013649 motif 3; other site 862719013650 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 862719013651 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862719013652 peptidase PmbA; Provisional; Region: PRK11040 862719013653 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 862719013654 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 862719013655 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 862719013656 putative active site [active] 862719013657 catalytic triad [active] 862719013658 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 862719013659 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 862719013660 dimerization interface [polypeptide binding]; other site 862719013661 ATP binding site [chemical binding]; other site 862719013662 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 862719013663 dimerization interface [polypeptide binding]; other site 862719013664 ATP binding site [chemical binding]; other site 862719013665 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 862719013666 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 862719013667 PIN domain; Region: PIN_3; cl17397 862719013668 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013670 active site 862719013671 phosphorylation site [posttranslational modification] 862719013672 intermolecular recognition site; other site 862719013673 dimerization interface [polypeptide binding]; other site 862719013674 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 862719013675 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 862719013676 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 862719013677 active site 862719013678 HIGH motif; other site 862719013679 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 862719013680 KMSKS motif; other site 862719013681 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 862719013682 tRNA binding surface [nucleotide binding]; other site 862719013683 anticodon binding site; other site 862719013684 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 862719013685 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 862719013686 active site 862719013687 HIGH motif; other site 862719013688 nucleotide binding site [chemical binding]; other site 862719013689 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 862719013690 active site 862719013691 KMSKS motif; other site 862719013692 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 862719013693 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862719013694 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 862719013695 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 862719013696 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 862719013697 conserved cys residue [active] 862719013698 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 862719013699 NAD synthetase; Provisional; Region: PRK13981 862719013700 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 862719013701 active site 862719013702 catalytic triad [active] 862719013703 dimer interface [polypeptide binding]; other site 862719013704 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 862719013705 Ligand Binding Site [chemical binding]; other site 862719013706 SnoaL-like domain; Region: SnoaL_4; cl17707 862719013707 SnoaL-like domain; Region: SnoaL_3; pfam13474 862719013708 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 862719013709 Beta-lactamase; Region: Beta-lactamase; pfam00144 862719013710 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 862719013711 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 862719013712 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 862719013713 Ligand binding site; other site 862719013714 Putative Catalytic site; other site 862719013715 DXD motif; other site 862719013716 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719013717 dimerization interface [polypeptide binding]; other site 862719013718 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719013719 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719013720 dimer interface [polypeptide binding]; other site 862719013721 putative CheW interface [polypeptide binding]; other site 862719013722 Protein of unknown function, DUF462; Region: DUF462; cl01190 862719013723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719013724 dimerization interface [polypeptide binding]; other site 862719013725 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719013726 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719013727 dimer interface [polypeptide binding]; other site 862719013728 putative CheW interface [polypeptide binding]; other site 862719013729 Predicted permeases [General function prediction only]; Region: COG0679 862719013730 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 862719013731 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 862719013732 putative deacylase active site [active] 862719013733 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 862719013734 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 862719013735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719013736 binding surface 862719013737 TPR motif; other site 862719013738 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 862719013739 Found in ATP-dependent protease La (LON); Region: LON; smart00464 862719013740 Uncharacterized conserved protein [Function unknown]; Region: COG2835 862719013741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 862719013742 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 862719013743 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 862719013744 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 862719013745 NAD(P) binding site [chemical binding]; other site 862719013746 homotetramer interface [polypeptide binding]; other site 862719013747 homodimer interface [polypeptide binding]; other site 862719013748 active site 862719013749 putative acyltransferase; Provisional; Region: PRK05790 862719013750 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719013751 dimer interface [polypeptide binding]; other site 862719013752 active site 862719013753 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 862719013754 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 862719013755 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 862719013756 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 862719013757 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 862719013758 Phage tail protein; Region: Sipho_tail; cl17486 862719013759 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 862719013760 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719013761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719013762 S-adenosylmethionine binding site [chemical binding]; other site 862719013763 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 862719013764 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 862719013765 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 862719013766 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 862719013767 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 862719013768 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 862719013769 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 862719013770 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719013771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719013772 Walker A/P-loop; other site 862719013773 ATP binding site [chemical binding]; other site 862719013774 Q-loop/lid; other site 862719013775 ABC transporter signature motif; other site 862719013776 Walker B; other site 862719013777 D-loop; other site 862719013778 H-loop/switch region; other site 862719013779 Predicted membrane protein [Function unknown]; Region: COG2311 862719013780 Protein of unknown function (DUF418); Region: DUF418; cl12135 862719013781 Protein of unknown function (DUF418); Region: DUF418; pfam04235 862719013782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719013783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719013784 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 862719013785 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 862719013786 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 862719013787 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 862719013788 putative dimer interface [polypeptide binding]; other site 862719013789 Predicted helicase [General function prediction only]; Region: COG4889 862719013790 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 862719013791 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 862719013792 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 862719013793 GTPase CgtA; Reviewed; Region: obgE; PRK12299 862719013794 GTP1/OBG; Region: GTP1_OBG; pfam01018 862719013795 Obg GTPase; Region: Obg; cd01898 862719013796 G1 box; other site 862719013797 GTP/Mg2+ binding site [chemical binding]; other site 862719013798 Switch I region; other site 862719013799 G2 box; other site 862719013800 G3 box; other site 862719013801 Switch II region; other site 862719013802 G4 box; other site 862719013803 G5 box; other site 862719013804 gamma-glutamyl kinase; Provisional; Region: PRK05429 862719013805 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 862719013806 nucleotide binding site [chemical binding]; other site 862719013807 homotetrameric interface [polypeptide binding]; other site 862719013808 putative phosphate binding site [ion binding]; other site 862719013809 putative allosteric binding site; other site 862719013810 PUA domain; Region: PUA; pfam01472 862719013811 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 862719013812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719013813 active site 862719013814 motif I; other site 862719013815 motif II; other site 862719013816 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 862719013817 NodB motif; other site 862719013818 putative active site [active] 862719013819 putative catalytic site [active] 862719013820 Zn binding site [ion binding]; other site 862719013821 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 862719013822 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 862719013823 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 862719013824 protein binding site [polypeptide binding]; other site 862719013825 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 862719013826 Catalytic dyad [active] 862719013827 Peptidase family M23; Region: Peptidase_M23; pfam01551 862719013828 phosphoglyceromutase; Provisional; Region: PRK05434 862719013829 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 862719013830 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 862719013831 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 862719013832 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 862719013833 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 862719013834 active site 862719013835 (T/H)XGH motif; other site 862719013836 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 862719013837 putative catalytic cysteine [active] 862719013838 hypothetical protein; Provisional; Region: PRK10621 862719013839 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862719013840 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 862719013841 putative active site [active] 862719013842 Ap4A binding site [chemical binding]; other site 862719013843 nudix motif; other site 862719013844 putative metal binding site [ion binding]; other site 862719013845 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 862719013846 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719013847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013848 active site 862719013849 phosphorylation site [posttranslational modification] 862719013850 intermolecular recognition site; other site 862719013851 dimerization interface [polypeptide binding]; other site 862719013852 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719013853 putative binding surface; other site 862719013854 active site 862719013855 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 862719013856 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 862719013857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719013858 ATP binding site [chemical binding]; other site 862719013859 Mg2+ binding site [ion binding]; other site 862719013860 G-X-G motif; other site 862719013861 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 862719013862 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 862719013863 putative CheA interaction surface; other site 862719013864 PAS domain; Region: PAS_9; pfam13426 862719013865 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719013866 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719013867 dimer interface [polypeptide binding]; other site 862719013868 putative CheW interface [polypeptide binding]; other site 862719013869 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 862719013870 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 862719013871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719013872 CheD chemotactic sensory transduction; Region: CheD; cl00810 862719013873 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 862719013874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013875 active site 862719013876 phosphorylation site [posttranslational modification] 862719013877 intermolecular recognition site; other site 862719013878 dimerization interface [polypeptide binding]; other site 862719013879 CheB methylesterase; Region: CheB_methylest; pfam01339 862719013880 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719013881 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719013882 dimer interface [polypeptide binding]; other site 862719013883 putative CheW interface [polypeptide binding]; other site 862719013884 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 862719013885 anti sigma factor interaction site; other site 862719013886 regulatory phosphorylation site [posttranslational modification]; other site 862719013887 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 862719013888 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013890 active site 862719013891 phosphorylation site [posttranslational modification] 862719013892 intermolecular recognition site; other site 862719013893 dimerization interface [polypeptide binding]; other site 862719013894 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 862719013895 Response regulator receiver domain; Region: Response_reg; pfam00072 862719013896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719013897 active site 862719013898 phosphorylation site [posttranslational modification] 862719013899 intermolecular recognition site; other site 862719013900 dimerization interface [polypeptide binding]; other site 862719013901 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 862719013902 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 862719013903 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 862719013904 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862719013905 RNA binding surface [nucleotide binding]; other site 862719013906 Predicted dehydrogenase [General function prediction only]; Region: COG0579 862719013907 hydroxyglutarate oxidase; Provisional; Region: PRK11728 862719013908 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 862719013909 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 862719013910 putative dimer interface [polypeptide binding]; other site 862719013911 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 862719013912 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719013913 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719013914 dimer interface [polypeptide binding]; other site 862719013915 putative CheW interface [polypeptide binding]; other site 862719013916 PilZ domain; Region: PilZ; pfam07238 862719013917 reverse gyrase; Reviewed; Region: PRK09401 862719013918 RmuC family; Region: RmuC; pfam02646 862719013919 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 862719013920 nudix motif; other site 862719013921 Protein of unknown function, DUF399; Region: DUF399; pfam04187 862719013922 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719013923 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719013924 classical (c) SDRs; Region: SDR_c; cd05233 862719013925 NAD(P) binding site [chemical binding]; other site 862719013926 active site 862719013927 aspartate aminotransferase; Provisional; Region: PRK05764 862719013928 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719013929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719013930 homodimer interface [polypeptide binding]; other site 862719013931 catalytic residue [active] 862719013932 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 862719013933 Peptidase family M48; Region: Peptidase_M48; cl12018 862719013934 TPR repeat; Region: TPR_11; pfam13414 862719013935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 862719013936 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 862719013937 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 862719013938 catalytic residues [active] 862719013939 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 862719013940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719013941 motif II; other site 862719013942 MT-A70; Region: MT-A70; cl01947 862719013943 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719013944 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719013945 ligand binding site [chemical binding]; other site 862719013946 flexible hinge region; other site 862719013947 putative switch regulator; other site 862719013948 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 862719013949 non-specific DNA interactions [nucleotide binding]; other site 862719013950 DNA binding site [nucleotide binding] 862719013951 sequence specific DNA binding site [nucleotide binding]; other site 862719013952 putative cAMP binding site [chemical binding]; other site 862719013953 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 862719013954 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 862719013955 DNA-binding site [nucleotide binding]; DNA binding site 862719013956 RNA-binding motif; other site 862719013957 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 862719013958 DNA-binding site [nucleotide binding]; DNA binding site 862719013959 RNA-binding motif; other site 862719013960 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 862719013961 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 862719013962 FMN binding site [chemical binding]; other site 862719013963 active site 862719013964 substrate binding site [chemical binding]; other site 862719013965 catalytic residue [active] 862719013966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719013967 catalytic core [active] 862719013968 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 862719013969 putative substrate binding site [chemical binding]; other site 862719013970 putative ATP binding site [chemical binding]; other site 862719013971 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 862719013972 B1 nucleotide binding pocket [chemical binding]; other site 862719013973 B2 nucleotide binding pocket [chemical binding]; other site 862719013974 CAS motifs; other site 862719013975 active site 862719013976 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 862719013977 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 862719013978 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 862719013979 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 862719013980 catalytic triad [active] 862719013981 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 862719013982 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 862719013983 metal binding triad; other site 862719013984 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 862719013985 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 862719013986 metal binding triad; other site 862719013987 Protein of unknown function; Region: DUF3971; pfam13116 862719013988 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 862719013989 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 862719013990 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 862719013991 active site 862719013992 HIGH motif; other site 862719013993 dimer interface [polypeptide binding]; other site 862719013994 KMSKS motif; other site 862719013995 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 862719013996 RNA binding surface [nucleotide binding]; other site 862719013997 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 862719013998 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 862719013999 heme binding site [chemical binding]; other site 862719014000 ferroxidase pore; other site 862719014001 ferroxidase diiron center [ion binding]; other site 862719014002 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 862719014003 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 862719014004 heme binding site [chemical binding]; other site 862719014005 ferroxidase pore; other site 862719014006 ferroxidase diiron center [ion binding]; other site 862719014007 AAA domain; Region: AAA_31; pfam13614 862719014008 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719014009 P-loop; other site 862719014010 Magnesium ion binding site [ion binding]; other site 862719014011 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 862719014012 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 862719014013 EamA-like transporter family; Region: EamA; pfam00892 862719014014 EamA-like transporter family; Region: EamA; pfam00892 862719014015 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 862719014016 FAD binding domain; Region: FAD_binding_4; pfam01565 862719014017 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 862719014018 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 862719014019 substrate binding site [chemical binding]; other site 862719014020 ligand binding site [chemical binding]; other site 862719014021 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 862719014022 nucleophilic elbow; other site 862719014023 catalytic triad; other site 862719014024 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719014025 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719014026 TM-ABC transporter signature motif; other site 862719014027 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 862719014028 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 862719014029 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719014030 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 862719014031 Isochorismatase family; Region: Isochorismatase; pfam00857 862719014032 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 862719014033 catalytic triad [active] 862719014034 conserved cis-peptide bond; other site 862719014035 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719014036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719014037 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719014038 dimerization interface [polypeptide binding]; other site 862719014039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719014040 PAS domain S-box; Region: sensory_box; TIGR00229 862719014041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719014042 putative active site [active] 862719014043 heme pocket [chemical binding]; other site 862719014044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719014045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719014046 dimer interface [polypeptide binding]; other site 862719014047 phosphorylation site [posttranslational modification] 862719014048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719014049 ATP binding site [chemical binding]; other site 862719014050 Mg2+ binding site [ion binding]; other site 862719014051 G-X-G motif; other site 862719014052 Response regulator receiver domain; Region: Response_reg; pfam00072 862719014053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719014054 active site 862719014055 phosphorylation site [posttranslational modification] 862719014056 intermolecular recognition site; other site 862719014057 dimerization interface [polypeptide binding]; other site 862719014058 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 862719014059 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 862719014060 dimerization interface 3.5A [polypeptide binding]; other site 862719014061 active site 862719014062 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 862719014063 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 862719014064 putative active site [active] 862719014065 substrate binding site [chemical binding]; other site 862719014066 putative cosubstrate binding site; other site 862719014067 catalytic site [active] 862719014068 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 862719014069 substrate binding site [chemical binding]; other site 862719014070 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 862719014071 active site 862719014072 catalytic residues [active] 862719014073 metal binding site [ion binding]; metal-binding site 862719014074 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 862719014075 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719014076 catalytic core [active] 862719014077 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 862719014078 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 862719014079 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 862719014080 ATP binding site [chemical binding]; other site 862719014081 Mg++ binding site [ion binding]; other site 862719014082 motif III; other site 862719014083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719014084 nucleotide binding region [chemical binding]; other site 862719014085 ATP-binding site [chemical binding]; other site 862719014086 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 862719014087 Winged helix-turn helix; Region: HTH_29; pfam13551 862719014088 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719014089 Winged helix-turn helix; Region: HTH_33; pfam13592 862719014090 Evidence 2b : Function of strongly homologous gene; Product type pe : putative enzyme 862719014091 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 862719014092 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 862719014093 active site 862719014094 catalytic residues [active] 862719014095 metal binding site [ion binding]; metal-binding site 862719014096 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 862719014097 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 862719014098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719014099 dimerization interface [polypeptide binding]; other site 862719014100 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719014101 dimer interface [polypeptide binding]; other site 862719014102 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719014103 putative CheW interface [polypeptide binding]; other site 862719014104 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 862719014105 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 862719014106 tellurite resistance protein terB; Region: terB; cd07176 862719014107 putative metal binding site [ion binding]; other site 862719014108 Predicted permeases [General function prediction only]; Region: COG0679 862719014109 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719014110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719014111 metal binding site [ion binding]; metal-binding site 862719014112 active site 862719014113 I-site; other site 862719014114 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719014115 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 862719014116 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 862719014117 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 862719014118 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 862719014119 Transglycosylase; Region: Transgly; cl17702 862719014120 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 862719014121 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 862719014122 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 862719014123 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719014124 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719014125 DNA binding residues [nucleotide binding] 862719014126 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 862719014127 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 862719014128 dimer interface [polypeptide binding]; other site 862719014129 putative functional site; other site 862719014130 putative MPT binding site; other site 862719014131 PBP superfamily domain; Region: PBP_like; pfam12727 862719014132 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 862719014133 MPT binding site; other site 862719014134 Response regulator receiver domain; Region: Response_reg; pfam00072 862719014135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719014136 active site 862719014137 phosphorylation site [posttranslational modification] 862719014138 intermolecular recognition site; other site 862719014139 dimerization interface [polypeptide binding]; other site 862719014140 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719014141 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719014142 metal binding site [ion binding]; metal-binding site 862719014143 active site 862719014144 I-site; other site 862719014145 PAS fold; Region: PAS; pfam00989 862719014146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719014147 putative active site [active] 862719014148 heme pocket [chemical binding]; other site 862719014149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719014150 dimer interface [polypeptide binding]; other site 862719014151 phosphorylation site [posttranslational modification] 862719014152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719014153 ATP binding site [chemical binding]; other site 862719014154 Mg2+ binding site [ion binding]; other site 862719014155 G-X-G motif; other site 862719014156 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719014157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719014158 active site 862719014159 phosphorylation site [posttranslational modification] 862719014160 intermolecular recognition site; other site 862719014161 dimerization interface [polypeptide binding]; other site 862719014162 Response regulator receiver domain; Region: Response_reg; pfam00072 862719014163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719014164 active site 862719014165 phosphorylation site [posttranslational modification] 862719014166 intermolecular recognition site; other site 862719014167 dimerization interface [polypeptide binding]; other site 862719014168 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 862719014169 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 862719014170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719014171 putative active site [active] 862719014172 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 862719014173 LytTr DNA-binding domain; Region: LytTR; smart00850 862719014174 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 862719014175 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 862719014176 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 862719014177 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 862719014178 trimer interface [polypeptide binding]; other site 862719014179 active site 862719014180 UDP-GlcNAc binding site [chemical binding]; other site 862719014181 lipid binding site [chemical binding]; lipid-binding site 862719014182 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 862719014183 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 862719014184 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719014185 ligand binding site [chemical binding]; other site 862719014186 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719014187 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 862719014188 acetyl-CoA synthetase; Provisional; Region: PRK00174 862719014189 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 862719014190 active site 862719014191 CoA binding site [chemical binding]; other site 862719014192 acyl-activating enzyme (AAE) consensus motif; other site 862719014193 AMP binding site [chemical binding]; other site 862719014194 acetate binding site [chemical binding]; other site 862719014195 EVE domain; Region: EVE; pfam01878 862719014196 YciI-like protein; Reviewed; Region: PRK12863 862719014197 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 862719014198 active site 862719014199 catalytic site [active] 862719014200 substrate binding site [chemical binding]; other site 862719014201 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 862719014202 ADP-ribose binding site [chemical binding]; other site 862719014203 dimer interface [polypeptide binding]; other site 862719014204 active site 862719014205 nudix motif; other site 862719014206 metal binding site [ion binding]; metal-binding site 862719014207 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719014208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719014209 S-adenosylmethionine binding site [chemical binding]; other site 862719014210 aconitate hydratase; Validated; Region: PRK09277 862719014211 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 862719014212 substrate binding site [chemical binding]; other site 862719014213 ligand binding site [chemical binding]; other site 862719014214 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 862719014215 substrate binding site [chemical binding]; other site 862719014216 HAMP domain; Region: HAMP; pfam00672 862719014217 PAS fold; Region: PAS_4; pfam08448 862719014218 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 862719014219 PAS fold; Region: PAS_4; pfam08448 862719014220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719014221 putative active site [active] 862719014222 heme pocket [chemical binding]; other site 862719014223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719014224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719014225 dimer interface [polypeptide binding]; other site 862719014226 phosphorylation site [posttranslational modification] 862719014227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719014228 ATP binding site [chemical binding]; other site 862719014229 Mg2+ binding site [ion binding]; other site 862719014230 G-X-G motif; other site 862719014231 Response regulator receiver domain; Region: Response_reg; pfam00072 862719014232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719014233 active site 862719014234 phosphorylation site [posttranslational modification] 862719014235 intermolecular recognition site; other site 862719014236 dimerization interface [polypeptide binding]; other site 862719014237 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 862719014238 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 862719014239 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 862719014240 catalytic triad [active] 862719014241 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 862719014242 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 862719014243 putative active site [active] 862719014244 catalytic site [active] 862719014245 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 862719014246 putative active site [active] 862719014247 catalytic site [active] 862719014248 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 862719014249 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719014250 ligand binding site [chemical binding]; other site 862719014251 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 862719014252 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 862719014253 NnrU protein; Region: NnrU; pfam07298 862719014254 FOG: CBS domain [General function prediction only]; Region: COG0517 862719014255 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 862719014256 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 862719014257 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 862719014258 DNA-binding site [nucleotide binding]; DNA binding site 862719014259 RNA-binding motif; other site 862719014260 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 862719014261 DNA-binding site [nucleotide binding]; DNA binding site 862719014262 RNA-binding motif; other site 862719014263 EamA-like transporter family; Region: EamA; pfam00892 862719014264 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 862719014265 PAS domain S-box; Region: sensory_box; TIGR00229 862719014266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719014267 putative active site [active] 862719014268 heme pocket [chemical binding]; other site 862719014269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719014270 dimer interface [polypeptide binding]; other site 862719014271 phosphorylation site [posttranslational modification] 862719014272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719014273 ATP binding site [chemical binding]; other site 862719014274 Mg2+ binding site [ion binding]; other site 862719014275 G-X-G motif; other site 862719014276 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719014277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719014278 active site 862719014279 phosphorylation site [posttranslational modification] 862719014280 intermolecular recognition site; other site 862719014281 dimerization interface [polypeptide binding]; other site 862719014282 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719014283 putative binding surface; other site 862719014284 active site 862719014285 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 862719014286 C-terminal domain interface [polypeptide binding]; other site 862719014287 GSH binding site (G-site) [chemical binding]; other site 862719014288 putative dimer interface [polypeptide binding]; other site 862719014289 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 862719014290 dimer interface [polypeptide binding]; other site 862719014291 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 862719014292 N-terminal domain interface [polypeptide binding]; other site 862719014293 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719014294 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719014295 Walker A/P-loop; other site 862719014296 ATP binding site [chemical binding]; other site 862719014297 Q-loop/lid; other site 862719014298 ABC transporter signature motif; other site 862719014299 Walker B; other site 862719014300 D-loop; other site 862719014301 H-loop/switch region; other site 862719014302 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719014303 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719014304 Walker A/P-loop; other site 862719014305 ATP binding site [chemical binding]; other site 862719014306 Q-loop/lid; other site 862719014307 ABC transporter signature motif; other site 862719014308 Walker B; other site 862719014309 D-loop; other site 862719014310 H-loop/switch region; other site 862719014311 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 862719014312 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719014313 TM-ABC transporter signature motif; other site 862719014314 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719014315 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719014316 TM-ABC transporter signature motif; other site 862719014317 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 862719014318 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 862719014319 putative ligand binding site [chemical binding]; other site 862719014320 PaaX-like protein; Region: PaaX; pfam07848 862719014321 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 862719014322 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 862719014323 Sensors of blue-light using FAD; Region: BLUF; pfam04940 862719014324 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 862719014325 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 862719014326 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719014327 catalytic loop [active] 862719014328 iron binding site [ion binding]; other site 862719014329 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 862719014330 FAD binding pocket [chemical binding]; other site 862719014331 FAD binding motif [chemical binding]; other site 862719014332 phosphate binding motif [ion binding]; other site 862719014333 beta-alpha-beta structure motif; other site 862719014334 NAD binding pocket [chemical binding]; other site 862719014335 Cache domain; Region: Cache_1; pfam02743 862719014336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719014337 dimerization interface [polypeptide binding]; other site 862719014338 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719014339 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719014340 dimer interface [polypeptide binding]; other site 862719014341 putative CheW interface [polypeptide binding]; other site 862719014342 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 862719014343 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 862719014344 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 862719014345 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719014346 MarR family; Region: MarR_2; pfam12802 862719014347 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719014348 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862719014349 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 862719014350 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 862719014351 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 862719014352 putative trimer interface [polypeptide binding]; other site 862719014353 putative metal binding site [ion binding]; other site 862719014354 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 862719014355 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 862719014356 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 862719014357 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 862719014358 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 862719014359 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 862719014360 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 862719014361 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 862719014362 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 862719014363 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 862719014364 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 862719014365 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 862719014366 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 862719014367 active site 862719014368 dimer interface [polypeptide binding]; other site 862719014369 motif 1; other site 862719014370 motif 2; other site 862719014371 motif 3; other site 862719014372 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 862719014373 anticodon binding site; other site 862719014374 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719014375 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 862719014376 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 862719014377 quinone interaction residues [chemical binding]; other site 862719014378 active site 862719014379 catalytic residues [active] 862719014380 FMN binding site [chemical binding]; other site 862719014381 substrate binding site [chemical binding]; other site 862719014382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 862719014383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 862719014384 Terminase-like family; Region: Terminase_6; pfam03237 862719014385 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 862719014386 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 862719014387 hypothetical protein; Region: PHA00661 862719014388 hypothetical protein; Region: PHA00662 862719014389 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 862719014390 Phage Tail Collar Domain; Region: Collar; pfam07484 862719014391 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 862719014392 metal binding site 2 [ion binding]; metal-binding site 862719014393 putative DNA binding helix; other site 862719014394 metal binding site 1 [ion binding]; metal-binding site 862719014395 dimer interface [polypeptide binding]; other site 862719014396 structural Zn2+ binding site [ion binding]; other site 862719014397 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 862719014398 E-class dimer interface [polypeptide binding]; other site 862719014399 P-class dimer interface [polypeptide binding]; other site 862719014400 active site 862719014401 Cu2+ binding site [ion binding]; other site 862719014402 Zn2+ binding site [ion binding]; other site 862719014403 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 862719014404 DEAD-like helicases superfamily; Region: DEXDc; smart00487 862719014405 ATP binding site [chemical binding]; other site 862719014406 Mg++ binding site [ion binding]; other site 862719014407 motif III; other site 862719014408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719014409 nucleotide binding region [chemical binding]; other site 862719014410 ATP-binding site [chemical binding]; other site 862719014411 glutathionine S-transferase; Provisional; Region: PRK10542 862719014412 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 862719014413 C-terminal domain interface [polypeptide binding]; other site 862719014414 GSH binding site (G-site) [chemical binding]; other site 862719014415 dimer interface [polypeptide binding]; other site 862719014416 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 862719014417 N-terminal domain interface [polypeptide binding]; other site 862719014418 dimer interface [polypeptide binding]; other site 862719014419 substrate binding pocket (H-site) [chemical binding]; other site 862719014420 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 862719014421 dinuclear metal binding motif [ion binding]; other site 862719014422 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 862719014423 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 862719014424 gamma subunit interface [polypeptide binding]; other site 862719014425 epsilon subunit interface [polypeptide binding]; other site 862719014426 LBP interface [polypeptide binding]; other site 862719014427 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 862719014428 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 862719014429 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 862719014430 alpha subunit interaction interface [polypeptide binding]; other site 862719014431 Walker A motif; other site 862719014432 ATP binding site [chemical binding]; other site 862719014433 Walker B motif; other site 862719014434 inhibitor binding site; inhibition site 862719014435 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862719014436 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 862719014437 core domain interface [polypeptide binding]; other site 862719014438 delta subunit interface [polypeptide binding]; other site 862719014439 epsilon subunit interface [polypeptide binding]; other site 862719014440 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 862719014441 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 862719014442 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 862719014443 beta subunit interaction interface [polypeptide binding]; other site 862719014444 Walker A motif; other site 862719014445 ATP binding site [chemical binding]; other site 862719014446 Walker B motif; other site 862719014447 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862719014448 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 862719014449 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 862719014450 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719014451 primosome assembly protein PriA; Validated; Region: PRK05580 862719014452 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719014453 ATP binding site [chemical binding]; other site 862719014454 putative Mg++ binding site [ion binding]; other site 862719014455 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 862719014456 active site 862719014457 intersubunit interactions; other site 862719014458 catalytic residue [active] 862719014459 Protein of unknown function, DUF484; Region: DUF484; cl17449 862719014460 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 862719014461 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719014462 active site 862719014463 DNA binding site [nucleotide binding] 862719014464 Int/Topo IB signature motif; other site 862719014465 Cache domain; Region: Cache_1; pfam02743 862719014466 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719014467 dimerization interface [polypeptide binding]; other site 862719014468 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719014469 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719014470 dimer interface [polypeptide binding]; other site 862719014471 putative CheW interface [polypeptide binding]; other site 862719014472 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 862719014473 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 862719014474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719014475 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 862719014476 Predicted small secreted protein [Function unknown]; Region: COG5510 862719014477 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 862719014478 DNA-binding site [nucleotide binding]; DNA binding site 862719014479 RNA-binding motif; other site 862719014480 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 862719014481 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 862719014482 putative ribose interaction site [chemical binding]; other site 862719014483 putative ADP binding site [chemical binding]; other site 862719014484 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 862719014485 active site 862719014486 nucleotide binding site [chemical binding]; other site 862719014487 HIGH motif; other site 862719014488 KMSKS motif; other site 862719014489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719014490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719014491 ATP binding site [chemical binding]; other site 862719014492 Mg2+ binding site [ion binding]; other site 862719014493 G-X-G motif; other site 862719014494 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 862719014495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719014496 S-adenosylmethionine binding site [chemical binding]; other site 862719014497 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719014498 ParA-like protein; Provisional; Region: PHA02518 862719014499 P-loop; other site 862719014500 Magnesium ion binding site [ion binding]; other site 862719014501 Uncharacterized conserved protein [Function unknown]; Region: COG3025 862719014502 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 862719014503 putative active site [active] 862719014504 putative metal binding residues [ion binding]; other site 862719014505 signature motif; other site 862719014506 putative triphosphate binding site [ion binding]; other site 862719014507 CHAD domain; Region: CHAD; pfam05235 862719014508 Phosphoglycerate kinase; Region: PGK; pfam00162 862719014509 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 862719014510 substrate binding site [chemical binding]; other site 862719014511 hinge regions; other site 862719014512 ADP binding site [chemical binding]; other site 862719014513 catalytic site [active] 862719014514 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 862719014515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719014516 Walker A motif; other site 862719014517 ATP binding site [chemical binding]; other site 862719014518 Walker B motif; other site 862719014519 arginine finger; other site 862719014520 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 862719014521 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 862719014522 hypothetical protein; Validated; Region: PRK00153 862719014523 recombination protein RecR; Reviewed; Region: recR; PRK00076 862719014524 RecR protein; Region: RecR; pfam02132 862719014525 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 862719014526 putative active site [active] 862719014527 putative metal-binding site [ion binding]; other site 862719014528 tetramer interface [polypeptide binding]; other site 862719014529 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 862719014530 hydroxyglutarate oxidase; Provisional; Region: PRK11728 862719014531 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 862719014532 active site 862719014533 HIGH motif; other site 862719014534 nucleotide binding site [chemical binding]; other site 862719014535 active site 862719014536 KMSKS motif; other site 862719014537 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 862719014538 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 862719014539 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 862719014540 active site 862719014541 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 862719014542 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 862719014543 DNA Polymerase Y-family; Region: PolY_like; cd03468 862719014544 active site 862719014545 DNA binding site [nucleotide binding] 862719014546 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 862719014547 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 862719014548 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 862719014549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719014550 Coenzyme A binding pocket [chemical binding]; other site 862719014551 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 862719014552 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 862719014553 C-terminal domain interface [polypeptide binding]; other site 862719014554 GSH binding site (G-site) [chemical binding]; other site 862719014555 dimer interface [polypeptide binding]; other site 862719014556 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 862719014557 dimer interface [polypeptide binding]; other site 862719014558 N-terminal domain interface [polypeptide binding]; other site 862719014559 substrate binding pocket (H-site) [chemical binding]; other site 862719014560 heat shock protein 90; Provisional; Region: PRK05218 862719014561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719014562 ATP binding site [chemical binding]; other site 862719014563 Mg2+ binding site [ion binding]; other site 862719014564 G-X-G motif; other site 862719014565 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719014566 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719014567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719014568 dimer interface [polypeptide binding]; other site 862719014569 phosphorylation site [posttranslational modification] 862719014570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719014571 ATP binding site [chemical binding]; other site 862719014572 Mg2+ binding site [ion binding]; other site 862719014573 G-X-G motif; other site 862719014574 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 862719014575 metal binding site 2 [ion binding]; metal-binding site 862719014576 putative DNA binding helix; other site 862719014577 metal binding site 1 [ion binding]; metal-binding site 862719014578 dimer interface [polypeptide binding]; other site 862719014579 structural Zn2+ binding site [ion binding]; other site 862719014580 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 862719014581 Response regulator receiver domain; Region: Response_reg; pfam00072 862719014582 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 862719014583 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719014584 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719014585 DNA binding residues [nucleotide binding] 862719014586 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 862719014587 Uncharacterized conserved protein [Function unknown]; Region: COG2128 862719014588 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 862719014589 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 862719014590 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 862719014591 ATP binding site [chemical binding]; other site 862719014592 substrate interface [chemical binding]; other site 862719014593 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 862719014594 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 862719014595 dimer interface [polypeptide binding]; other site 862719014596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719014597 catalytic residue [active] 862719014598 Rrf2 family protein; Region: rrf2_super; TIGR00738 862719014599 Transcriptional regulator; Region: Rrf2; pfam02082 862719014600 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 862719014601 Predicted transcriptional regulators [Transcription]; Region: COG1695 862719014602 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 862719014603 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 862719014604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862719014605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719014606 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719014607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719014608 dimer interface [polypeptide binding]; other site 862719014609 conserved gate region; other site 862719014610 putative PBP binding loops; other site 862719014611 ABC-ATPase subunit interface; other site 862719014612 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 862719014613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719014614 dimer interface [polypeptide binding]; other site 862719014615 conserved gate region; other site 862719014616 ABC-ATPase subunit interface; other site 862719014617 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 862719014618 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719014619 Walker A/P-loop; other site 862719014620 ATP binding site [chemical binding]; other site 862719014621 Q-loop/lid; other site 862719014622 ABC transporter signature motif; other site 862719014623 Walker B; other site 862719014624 D-loop; other site 862719014625 H-loop/switch region; other site 862719014626 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719014627 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 862719014628 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719014629 Walker A/P-loop; other site 862719014630 ATP binding site [chemical binding]; other site 862719014631 Q-loop/lid; other site 862719014632 ABC transporter signature motif; other site 862719014633 Walker B; other site 862719014634 D-loop; other site 862719014635 H-loop/switch region; other site 862719014636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719014637 non-specific DNA binding site [nucleotide binding]; other site 862719014638 salt bridge; other site 862719014639 sequence-specific DNA binding site [nucleotide binding]; other site 862719014640 Protein of unknown function (DUF497); Region: DUF497; pfam04365 862719014641 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719014642 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719014643 HerA helicase [Replication, recombination, and repair]; Region: COG0433 862719014644 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 862719014645 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719014646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719014647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719014648 dimerization interface [polypeptide binding]; other site 862719014649 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 862719014650 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 862719014651 putative NAD(P) binding site [chemical binding]; other site 862719014652 dimer interface [polypeptide binding]; other site 862719014653 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 862719014654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719014655 active site 862719014656 phosphorylation site [posttranslational modification] 862719014657 intermolecular recognition site; other site 862719014658 dimerization interface [polypeptide binding]; other site 862719014659 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719014660 dimerization interface [polypeptide binding]; other site 862719014661 DNA binding residues [nucleotide binding] 862719014662 EamA-like transporter family; Region: EamA; pfam00892 862719014663 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719014664 EamA-like transporter family; Region: EamA; pfam00892 862719014665 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 862719014666 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 862719014667 ring oligomerisation interface [polypeptide binding]; other site 862719014668 ATP/Mg binding site [chemical binding]; other site 862719014669 stacking interactions; other site 862719014670 hinge regions; other site 862719014671 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 862719014672 oligomerisation interface [polypeptide binding]; other site 862719014673 mobile loop; other site 862719014674 roof hairpin; other site 862719014675 Usg-like family; Region: Usg; cl11567 862719014676 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 862719014677 catalytic residues [active] 862719014678 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 862719014679 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 862719014680 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719014681 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719014682 ligand binding site [chemical binding]; other site 862719014683 flexible hinge region; other site 862719014684 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 862719014685 putative switch regulator; other site 862719014686 non-specific DNA interactions [nucleotide binding]; other site 862719014687 DNA binding site [nucleotide binding] 862719014688 sequence specific DNA binding site [nucleotide binding]; other site 862719014689 putative cAMP binding site [chemical binding]; other site 862719014690 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 862719014691 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 862719014692 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 862719014693 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 862719014694 metal-binding site [ion binding] 862719014695 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862719014696 Soluble P-type ATPase [General function prediction only]; Region: COG4087 862719014697 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 862719014698 FixH; Region: FixH; pfam05751 862719014699 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 862719014700 Cytochrome c; Region: Cytochrom_C; pfam00034 862719014701 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 862719014702 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 862719014703 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 862719014704 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 862719014705 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 862719014706 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 862719014707 Low-spin heme binding site [chemical binding]; other site 862719014708 Putative water exit pathway; other site 862719014709 Binuclear center (active site) [active] 862719014710 Putative proton exit pathway; other site 862719014711 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 862719014712 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 862719014713 putative RNA binding site [nucleotide binding]; other site 862719014714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719014715 S-adenosylmethionine binding site [chemical binding]; other site 862719014716 TRAM domain; Region: TRAM; cl01282 862719014717 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 862719014718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719014719 S-adenosylmethionine binding site [chemical binding]; other site 862719014720 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 862719014721 active site 862719014722 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719014723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719014724 dimer interface [polypeptide binding]; other site 862719014725 conserved gate region; other site 862719014726 putative PBP binding loops; other site 862719014727 ABC-ATPase subunit interface; other site 862719014728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719014729 dimer interface [polypeptide binding]; other site 862719014730 ABC-ATPase subunit interface; other site 862719014731 putative PBP binding loops; other site 862719014732 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719014733 putative binding surface; other site 862719014734 active site 862719014735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 862719014736 phosphorylation site [posttranslational modification] 862719014737 intermolecular recognition site; other site 862719014738 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 862719014739 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 862719014740 substrate-cofactor binding pocket; other site 862719014741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719014742 catalytic residue [active] 862719014743 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 862719014744 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719014745 active site 862719014746 diguanylate cyclase; Provisional; Region: PRK09894 862719014747 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 862719014748 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719014749 metal binding site [ion binding]; metal-binding site 862719014750 active site 862719014751 I-site; other site 862719014752 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 862719014753 active site 862719014754 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 862719014755 active site 862719014756 dimer interface [polypeptide binding]; other site 862719014757 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 862719014758 heme binding pocket [chemical binding]; other site 862719014759 heme ligand [chemical binding]; other site 862719014760 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719014761 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 862719014762 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 862719014763 Walker A/P-loop; other site 862719014764 ATP binding site [chemical binding]; other site 862719014765 Q-loop/lid; other site 862719014766 ABC transporter signature motif; other site 862719014767 Walker B; other site 862719014768 D-loop; other site 862719014769 H-loop/switch region; other site 862719014770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719014771 dimerization interface [polypeptide binding]; other site 862719014772 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719014773 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719014774 dimer interface [polypeptide binding]; other site 862719014775 putative CheW interface [polypeptide binding]; other site 862719014776 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 862719014777 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 862719014778 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 862719014779 G1 box; other site 862719014780 GTP/Mg2+ binding site [chemical binding]; other site 862719014781 G2 box; other site 862719014782 Switch I region; other site 862719014783 G3 box; other site 862719014784 Switch II region; other site 862719014785 G4 box; other site 862719014786 G5 box; other site 862719014787 TIR domain; Region: TIR_2; pfam13676 862719014788 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 862719014789 DTW domain; Region: DTW; cl01221 862719014790 Uncharacterized conserved protein [Function unknown]; Region: COG4544 862719014791 Bacterial SH3 domain; Region: SH3_3; cl17532 862719014792 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 862719014793 Ca2+ binding site [ion binding]; other site 862719014794 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 862719014795 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719014796 FeS/SAM binding site; other site 862719014797 HemN C-terminal domain; Region: HemN_C; pfam06969 862719014798 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 862719014799 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 862719014800 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 862719014801 FOG: CBS domain [General function prediction only]; Region: COG0517 862719014802 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 862719014803 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 862719014804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719014805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719014806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719014807 dimerization interface [polypeptide binding]; other site 862719014808 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 862719014809 4Fe-4S binding domain; Region: Fer4; cl02805 862719014810 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 862719014811 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 862719014812 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862719014813 active site 862719014814 metal binding site [ion binding]; metal-binding site 862719014815 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 862719014816 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719014817 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 862719014818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719014819 DNA binding residues [nucleotide binding] 862719014820 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 862719014821 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 862719014822 purine monophosphate binding site [chemical binding]; other site 862719014823 dimer interface [polypeptide binding]; other site 862719014824 putative catalytic residues [active] 862719014825 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 862719014826 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 862719014827 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 862719014828 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 862719014829 putative RNA binding site [nucleotide binding]; other site 862719014830 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 862719014831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719014832 S-adenosylmethionine binding site [chemical binding]; other site 862719014833 enoyl-CoA hydratase; Provisional; Region: PRK06127 862719014834 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719014835 substrate binding site [chemical binding]; other site 862719014836 oxyanion hole (OAH) forming residues; other site 862719014837 trimer interface [polypeptide binding]; other site 862719014838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719014839 putative transporter; Provisional; Region: PRK10504 862719014840 putative substrate translocation pore; other site 862719014841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719014842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719014843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719014844 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719014845 putative effector binding pocket; other site 862719014846 dimerization interface [polypeptide binding]; other site 862719014847 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 862719014848 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 862719014849 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 862719014850 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 862719014851 MarR family; Region: MarR; pfam01047 862719014852 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 862719014853 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 862719014854 dimerization interface [polypeptide binding]; other site 862719014855 ligand binding site [chemical binding]; other site 862719014856 NADP binding site [chemical binding]; other site 862719014857 catalytic site [active] 862719014858 Bacterial SH3 domain; Region: SH3_4; pfam06347 862719014859 Bacterial SH3 domain; Region: SH3_4; pfam06347 862719014860 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719014861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719014862 putative substrate translocation pore; other site 862719014863 argininosuccinate synthase; Provisional; Region: PRK13820 862719014864 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 862719014865 ANP binding site [chemical binding]; other site 862719014866 Substrate Binding Site II [chemical binding]; other site 862719014867 Substrate Binding Site I [chemical binding]; other site 862719014868 RES domain; Region: RES; smart00953 862719014869 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 862719014870 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 862719014871 type II restriction endonuclease, Alw26I/Eco31I/Esp3I family; Region: restrict_Alw26I; TIGR02986 862719014872 Predicted flavoprotein [General function prediction only]; Region: COG0431 862719014873 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 862719014874 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719014875 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862719014876 active site 862719014877 catalytic tetrad [active] 862719014878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719014879 NAD(P) binding site [chemical binding]; other site 862719014880 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 862719014881 active site 862719014882 Uncharacterized conserved protein [Function unknown]; Region: COG3339 862719014883 EamA-like transporter family; Region: EamA; pfam00892 862719014884 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719014885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719014886 Histidine kinase; Region: HisKA_2; pfam07568 862719014887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719014888 ATP binding site [chemical binding]; other site 862719014889 Mg2+ binding site [ion binding]; other site 862719014890 G-X-G motif; other site 862719014891 ornithine cyclodeaminase; Validated; Region: PRK06141 862719014892 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 862719014893 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 862719014894 IHF dimer interface [polypeptide binding]; other site 862719014895 IHF - DNA interface [nucleotide binding]; other site 862719014896 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719014897 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 862719014898 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719014899 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 862719014900 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719014901 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 862719014902 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719014903 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 862719014904 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862719014905 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719014906 protein binding site [polypeptide binding]; other site 862719014907 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 862719014908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719014909 Histidine kinase; Region: HisKA_2; pfam07568 862719014910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719014911 ATP binding site [chemical binding]; other site 862719014912 Mg2+ binding site [ion binding]; other site 862719014913 G-X-G motif; other site 862719014914 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 862719014915 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 862719014916 dimerization interface [polypeptide binding]; other site 862719014917 DPS ferroxidase diiron center [ion binding]; other site 862719014918 ion pore; other site 862719014919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719014920 dimerization interface [polypeptide binding]; other site 862719014921 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719014922 dimer interface [polypeptide binding]; other site 862719014923 putative CheW interface [polypeptide binding]; other site 862719014924 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16303747, 17628132, 8522505; Product type prc : putative receptor 862719014925 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 862719014926 elongation factor G; Reviewed; Region: PRK12740 862719014927 G1 box; other site 862719014928 putative GEF interaction site [polypeptide binding]; other site 862719014929 GTP/Mg2+ binding site [chemical binding]; other site 862719014930 Switch I region; other site 862719014931 G2 box; other site 862719014932 G3 box; other site 862719014933 Switch II region; other site 862719014934 G4 box; other site 862719014935 G5 box; other site 862719014936 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 862719014937 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 862719014938 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 862719014939 PemK-like protein; Region: PemK; cl00995 862719014940 Winged helix-turn helix; Region: HTH_29; pfam13551 862719014941 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719014942 Homeodomain-like domain; Region: HTH_32; pfam13565 862719014943 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719014944 aspartate aminotransferase; Provisional; Region: PRK05764 862719014945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719014946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719014947 homodimer interface [polypeptide binding]; other site 862719014948 catalytic residue [active] 862719014949 Cytochrome C' Region: Cytochrom_C_2; pfam01322 862719014950 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 862719014951 cytochrome c-550; Provisional; Region: psbV; cl17239 862719014952 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 862719014953 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 862719014954 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 862719014955 putative active site [active] 862719014956 putative metal binding site [ion binding]; other site 862719014957 PAS domain S-box; Region: sensory_box; TIGR00229 862719014958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719014959 putative active site [active] 862719014960 heme pocket [chemical binding]; other site 862719014961 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719014962 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719014963 metal binding site [ion binding]; metal-binding site 862719014964 active site 862719014965 I-site; other site 862719014966 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719014967 hypothetical protein; Region: PHA00670 862719014968 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 862719014969 Predicted transcriptional regulator [Transcription]; Region: COG2932 862719014970 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 862719014971 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 862719014972 Catalytic site [active] 862719014973 aminotransferase; Provisional; Region: PRK13356 862719014974 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 862719014975 homodimer interface [polypeptide binding]; other site 862719014976 substrate-cofactor binding pocket; other site 862719014977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719014978 catalytic residue [active] 862719014979 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 862719014980 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 862719014981 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 862719014982 L-aspartate oxidase; Provisional; Region: PRK06175 862719014983 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 862719014984 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 862719014985 putative SdhC subunit interface [polypeptide binding]; other site 862719014986 putative proximal heme binding site [chemical binding]; other site 862719014987 putative Iron-sulfur protein interface [polypeptide binding]; other site 862719014988 putative proximal quinone binding site; other site 862719014989 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 862719014990 Iron-sulfur protein interface; other site 862719014991 proximal quinone binding site [chemical binding]; other site 862719014992 SdhD (CybS) interface [polypeptide binding]; other site 862719014993 proximal heme binding site [chemical binding]; other site 862719014994 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719014995 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 862719014996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719014997 FeS/SAM binding site; other site 862719014998 Response regulator receiver domain; Region: Response_reg; pfam00072 862719014999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015000 active site 862719015001 phosphorylation site [posttranslational modification] 862719015002 intermolecular recognition site; other site 862719015003 dimerization interface [polypeptide binding]; other site 862719015004 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 862719015005 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719015006 Zn2+ binding site [ion binding]; other site 862719015007 Mg2+ binding site [ion binding]; other site 862719015008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 862719015009 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 862719015010 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 862719015011 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 862719015012 C-terminal domain interface [polypeptide binding]; other site 862719015013 GSH binding site (G-site) [chemical binding]; other site 862719015014 dimer interface [polypeptide binding]; other site 862719015015 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 862719015016 N-terminal domain interface [polypeptide binding]; other site 862719015017 dimer interface [polypeptide binding]; other site 862719015018 substrate binding pocket (H-site) [chemical binding]; other site 862719015019 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 862719015020 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 862719015021 metal binding site [ion binding]; metal-binding site 862719015022 putative dimer interface [polypeptide binding]; other site 862719015023 PrcB C-terminal; Region: PrcB_C; pfam14343 862719015024 PAS fold; Region: PAS_4; pfam08448 862719015025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719015026 putative active site [active] 862719015027 heme pocket [chemical binding]; other site 862719015028 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719015029 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719015030 metal binding site [ion binding]; metal-binding site 862719015031 active site 862719015032 I-site; other site 862719015033 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719015034 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719015035 Ligand Binding Site [chemical binding]; other site 862719015036 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 862719015037 Family description; Region: DsbD_2; pfam13386 862719015038 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 862719015039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719015040 S-adenosylmethionine binding site [chemical binding]; other site 862719015041 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 862719015042 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 862719015043 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719015044 active site 862719015045 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 862719015046 GSH binding site [chemical binding]; other site 862719015047 catalytic residues [active] 862719015048 nitrilase; Region: PLN02798 862719015049 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 862719015050 putative active site [active] 862719015051 catalytic triad [active] 862719015052 dimer interface [polypeptide binding]; other site 862719015053 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 862719015054 active site 862719015055 catalytic site [active] 862719015056 substrate binding site [chemical binding]; other site 862719015057 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 862719015058 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719015059 ligand binding site [chemical binding]; other site 862719015060 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 862719015061 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 862719015062 metal binding triad; other site 862719015063 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 862719015064 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 862719015065 Na binding site [ion binding]; other site 862719015066 Protein of unknown function, DUF485; Region: DUF485; pfam04341 862719015067 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 862719015068 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 862719015069 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719015070 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 862719015071 L-asparaginase II; Region: Asparaginase_II; pfam06089 862719015072 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 862719015073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719015074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 862719015075 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 862719015076 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719015077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719015078 S-adenosylmethionine binding site [chemical binding]; other site 862719015079 aminotransferase; Provisional; Region: PRK06105 862719015080 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719015081 inhibitor-cofactor binding pocket; inhibition site 862719015082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719015083 catalytic residue [active] 862719015084 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 862719015085 Clp amino terminal domain; Region: Clp_N; pfam02861 862719015086 Clp amino terminal domain; Region: Clp_N; pfam02861 862719015087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719015088 Walker A motif; other site 862719015089 ATP binding site [chemical binding]; other site 862719015090 Walker B motif; other site 862719015091 arginine finger; other site 862719015092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719015093 Walker A motif; other site 862719015094 ATP binding site [chemical binding]; other site 862719015095 Walker B motif; other site 862719015096 arginine finger; other site 862719015097 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 862719015098 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 862719015099 nudix motif; other site 862719015100 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 862719015101 MOSC domain; Region: MOSC; pfam03473 862719015102 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 862719015103 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 862719015104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719015105 S-adenosylmethionine binding site [chemical binding]; other site 862719015106 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 862719015107 putative active site [active] 862719015108 peptide chain release factor 1; Validated; Region: prfA; PRK00591 862719015109 This domain is found in peptide chain release factors; Region: PCRF; smart00937 862719015110 RF-1 domain; Region: RF-1; pfam00472 862719015111 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 862719015112 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 862719015113 NAD(P) binding pocket [chemical binding]; other site 862719015114 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 862719015115 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 862719015116 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 862719015117 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 862719015118 Helix-turn-helix domain; Region: HTH_25; pfam13413 862719015119 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 862719015120 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 862719015121 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 862719015122 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 862719015123 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 862719015124 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 862719015125 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 862719015126 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 862719015127 FMN binding site [chemical binding]; other site 862719015128 substrate binding site [chemical binding]; other site 862719015129 putative catalytic residue [active] 862719015130 aspartate kinase; Reviewed; Region: PRK06635 862719015131 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 862719015132 putative nucleotide binding site [chemical binding]; other site 862719015133 putative catalytic residues [active] 862719015134 putative Mg ion binding site [ion binding]; other site 862719015135 putative aspartate binding site [chemical binding]; other site 862719015136 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 862719015137 putative allosteric regulatory site; other site 862719015138 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 862719015139 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 862719015140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719015141 S-adenosylmethionine binding site [chemical binding]; other site 862719015142 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 862719015143 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 862719015144 Zn binding site [ion binding]; other site 862719015145 toxin interface [polypeptide binding]; other site 862719015146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719015147 non-specific DNA binding site [nucleotide binding]; other site 862719015148 salt bridge; other site 862719015149 sequence-specific DNA binding site [nucleotide binding]; other site 862719015150 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 862719015151 peptide binding site [polypeptide binding]; other site 862719015152 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 862719015153 putative active site [active] 862719015154 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 862719015155 active site 862719015156 phosphorylation site [posttranslational modification] 862719015157 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 862719015158 30S subunit binding site; other site 862719015159 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 862719015160 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 862719015161 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 862719015162 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 862719015163 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 862719015164 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 862719015165 Walker A/P-loop; other site 862719015166 ATP binding site [chemical binding]; other site 862719015167 Q-loop/lid; other site 862719015168 ABC transporter signature motif; other site 862719015169 Walker B; other site 862719015170 D-loop; other site 862719015171 H-loop/switch region; other site 862719015172 OstA-like protein; Region: OstA; cl00844 862719015173 OstA-like protein; Region: OstA; cl00844 862719015174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 862719015175 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 862719015176 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 862719015177 putative active site [active] 862719015178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 862719015179 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 862719015180 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 862719015181 catalytic site [active] 862719015182 putative active site [active] 862719015183 putative substrate binding site [chemical binding]; other site 862719015184 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 862719015185 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 862719015186 putative NAD(P) binding site [chemical binding]; other site 862719015187 active site 862719015188 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862719015189 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 862719015190 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 862719015191 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862719015192 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 862719015193 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 862719015194 active site 862719015195 dimer interface [polypeptide binding]; other site 862719015196 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 862719015197 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 862719015198 active site 862719015199 FMN binding site [chemical binding]; other site 862719015200 substrate binding site [chemical binding]; other site 862719015201 3Fe-4S cluster binding site [ion binding]; other site 862719015202 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 862719015203 domain interface; other site 862719015204 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 862719015205 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 862719015206 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 862719015207 putative C-terminal domain interface [polypeptide binding]; other site 862719015208 putative GSH binding site (G-site) [chemical binding]; other site 862719015209 putative dimer interface [polypeptide binding]; other site 862719015210 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 862719015211 putative substrate binding pocket (H-site) [chemical binding]; other site 862719015212 putative N-terminal domain interface [polypeptide binding]; other site 862719015213 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 862719015214 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 862719015215 interface (dimer of trimers) [polypeptide binding]; other site 862719015216 Substrate-binding/catalytic site; other site 862719015217 Zn-binding sites [ion binding]; other site 862719015218 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 862719015219 FliG C-terminal domain; Region: FliG_C; pfam01706 862719015220 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719015221 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719015222 ligand binding site [chemical binding]; other site 862719015223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719015224 flexible hinge region; other site 862719015225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 862719015226 dimer interface [polypeptide binding]; other site 862719015227 phosphorylation site [posttranslational modification] 862719015228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015229 ATP binding site [chemical binding]; other site 862719015230 Mg2+ binding site [ion binding]; other site 862719015231 G-X-G motif; other site 862719015232 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 862719015233 Low molecular weight phosphatase family; Region: LMWPc; cd00115 862719015234 active site 862719015235 NAD-dependent deacetylase; Provisional; Region: PRK00481 862719015236 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 862719015237 NAD+ binding site [chemical binding]; other site 862719015238 substrate binding site [chemical binding]; other site 862719015239 Zn binding site [ion binding]; other site 862719015240 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 862719015241 putative uracil binding site [chemical binding]; other site 862719015242 putative active site [active] 862719015243 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 862719015244 pterin-4-alpha-carbinolamine dehydratase; Validated; Region: phhB; PRK00823 862719015245 aromatic arch; other site 862719015246 DCoH dimer interaction site [polypeptide binding]; other site 862719015247 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 862719015248 DCoH tetramer interaction site [polypeptide binding]; other site 862719015249 substrate binding site [chemical binding]; other site 862719015250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 862719015251 dimerization interface [polypeptide binding]; other site 862719015252 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719015253 dimer interface [polypeptide binding]; other site 862719015254 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719015255 putative CheW interface [polypeptide binding]; other site 862719015256 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 862719015257 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 862719015258 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 862719015259 dimer interface [polypeptide binding]; other site 862719015260 substrate binding site [chemical binding]; other site 862719015261 metal binding sites [ion binding]; metal-binding site 862719015262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719015263 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719015264 NAD(P) binding site [chemical binding]; other site 862719015265 active site 862719015266 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719015267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719015268 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719015269 dimerization interface [polypeptide binding]; other site 862719015270 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 862719015271 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 862719015272 NAD(P) binding site [chemical binding]; other site 862719015273 LDH/MDH dimer interface [polypeptide binding]; other site 862719015274 substrate binding site [chemical binding]; other site 862719015275 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 862719015276 CoA binding domain; Region: CoA_binding_2; pfam13380 862719015277 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 862719015278 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 862719015279 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 862719015280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719015281 Coenzyme A binding pocket [chemical binding]; other site 862719015282 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719015283 Winged helix-turn helix; Region: HTH_29; pfam13551 862719015284 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719015285 Homeodomain-like domain; Region: HTH_32; pfam13565 862719015286 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 862719015287 alanine-tRNA ligase; Region: PLN02961 862719015288 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 862719015289 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 862719015290 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 862719015291 dimerization interface [polypeptide binding]; other site 862719015292 active site 862719015293 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 862719015294 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 862719015295 Cl binding site [ion binding]; other site 862719015296 oligomer interface [polypeptide binding]; other site 862719015297 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 862719015298 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 862719015299 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 862719015300 homodimer interface [polypeptide binding]; other site 862719015301 NADP binding site [chemical binding]; other site 862719015302 substrate binding site [chemical binding]; other site 862719015303 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 862719015304 YGGT family; Region: YGGT; pfam02325 862719015305 EamA-like transporter family; Region: EamA; pfam00892 862719015306 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 862719015307 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 862719015308 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 862719015309 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 862719015310 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 862719015311 substrate binding site [chemical binding]; other site 862719015312 active site 862719015313 catalytic residues [active] 862719015314 heterodimer interface [polypeptide binding]; other site 862719015315 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 862719015316 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 862719015317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719015318 catalytic residue [active] 862719015319 Response regulator receiver domain; Region: Response_reg; pfam00072 862719015320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015321 active site 862719015322 phosphorylation site [posttranslational modification] 862719015323 intermolecular recognition site; other site 862719015324 dimerization interface [polypeptide binding]; other site 862719015325 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 862719015326 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 862719015327 DNA-binding site [nucleotide binding]; DNA binding site 862719015328 RNA-binding motif; other site 862719015329 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719015330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015331 active site 862719015332 phosphorylation site [posttranslational modification] 862719015333 intermolecular recognition site; other site 862719015334 dimerization interface [polypeptide binding]; other site 862719015335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719015336 Walker A motif; other site 862719015337 ATP binding site [chemical binding]; other site 862719015338 Walker B motif; other site 862719015339 arginine finger; other site 862719015340 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719015341 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 862719015342 Flavoprotein; Region: Flavoprotein; pfam02441 862719015343 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 862719015344 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 862719015345 trimer interface [polypeptide binding]; other site 862719015346 active site 862719015347 HAMP domain; Region: HAMP; pfam00672 862719015348 PAS domain S-box; Region: sensory_box; TIGR00229 862719015349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719015350 dimer interface [polypeptide binding]; other site 862719015351 phosphorylation site [posttranslational modification] 862719015352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015353 ATP binding site [chemical binding]; other site 862719015354 Mg2+ binding site [ion binding]; other site 862719015355 G-X-G motif; other site 862719015356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015357 Response regulator receiver domain; Region: Response_reg; pfam00072 862719015358 active site 862719015359 phosphorylation site [posttranslational modification] 862719015360 intermolecular recognition site; other site 862719015361 dimerization interface [polypeptide binding]; other site 862719015362 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719015363 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719015364 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 862719015365 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 862719015366 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 862719015367 active site 862719015368 DNA binding site [nucleotide binding] 862719015369 Int/Topo IB signature motif; other site 862719015370 shikimate kinase; Provisional; Region: PRK13946 862719015371 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 862719015372 ADP binding site [chemical binding]; other site 862719015373 magnesium binding site [ion binding]; other site 862719015374 putative shikimate binding site; other site 862719015375 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 862719015376 active site 862719015377 dimer interface [polypeptide binding]; other site 862719015378 metal binding site [ion binding]; metal-binding site 862719015379 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 862719015380 putative hydrophobic ligand binding site [chemical binding]; other site 862719015381 protein interface [polypeptide binding]; other site 862719015382 gate; other site 862719015383 FOG: CBS domain [General function prediction only]; Region: COG0517 862719015384 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 862719015385 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 862719015386 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 862719015387 BolA-like protein; Region: BolA; pfam01722 862719015388 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 862719015389 HSP70 interaction site [polypeptide binding]; other site 862719015390 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 862719015391 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 862719015392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 862719015393 GxxExxY protein; Region: GxxExxY; TIGR04256 862719015394 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 862719015395 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 862719015396 metal ion-dependent adhesion site (MIDAS); other site 862719015397 HAMP domain; Region: HAMP; pfam00672 862719015398 dimerization interface [polypeptide binding]; other site 862719015399 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 862719015400 cyclase homology domain; Region: CHD; cd07302 862719015401 nucleotidyl binding site; other site 862719015402 metal binding site [ion binding]; metal-binding site 862719015403 dimer interface [polypeptide binding]; other site 862719015404 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 862719015405 Peptidase family M48; Region: Peptidase_M48; pfam01435 862719015406 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 862719015407 Catalytic site; other site 862719015408 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 862719015409 Cytochrome c; Region: Cytochrom_C; pfam00034 862719015410 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 862719015411 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 862719015412 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 862719015413 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 862719015414 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 862719015415 dimerization domain swap beta strand [polypeptide binding]; other site 862719015416 regulatory protein interface [polypeptide binding]; other site 862719015417 active site 862719015418 regulatory phosphorylation site [posttranslational modification]; other site 862719015419 Evidence 2b : Function of strongly homologous gene; Product type t : transporter 862719015420 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 862719015421 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 862719015422 Hpr binding site; other site 862719015423 active site 862719015424 homohexamer subunit interaction site [polypeptide binding]; other site 862719015425 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 862719015426 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 862719015427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719015428 HAMP domain; Region: HAMP; pfam00672 862719015429 dimerization interface [polypeptide binding]; other site 862719015430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719015431 dimer interface [polypeptide binding]; other site 862719015432 phosphorylation site [posttranslational modification] 862719015433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015434 ATP binding site [chemical binding]; other site 862719015435 Mg2+ binding site [ion binding]; other site 862719015436 G-X-G motif; other site 862719015437 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719015438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015439 active site 862719015440 phosphorylation site [posttranslational modification] 862719015441 intermolecular recognition site; other site 862719015442 dimerization interface [polypeptide binding]; other site 862719015443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719015444 DNA binding site [nucleotide binding] 862719015445 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 862719015446 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 862719015447 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 862719015448 active site 862719015449 substrate-binding site [chemical binding]; other site 862719015450 metal-binding site [ion binding] 862719015451 GTP binding site [chemical binding]; other site 862719015452 Predicted membrane protein [Function unknown]; Region: COG4420 862719015453 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 862719015454 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 862719015455 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 862719015456 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 862719015457 putative acyl-acceptor binding pocket; other site 862719015458 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 862719015459 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 862719015460 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 862719015461 CPxP motif; other site 862719015462 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 862719015463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719015464 Coenzyme A binding pocket [chemical binding]; other site 862719015465 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 862719015466 Glycoprotease family; Region: Peptidase_M22; pfam00814 862719015467 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 862719015468 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 862719015469 putative active site [active] 862719015470 putative metal binding site [ion binding]; other site 862719015471 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 862719015472 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 862719015473 nucleotide binding site [chemical binding]; other site 862719015474 NEF interaction site [polypeptide binding]; other site 862719015475 SBD interface [polypeptide binding]; other site 862719015476 chaperone protein DnaJ; Provisional; Region: PRK10767 862719015477 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 862719015478 HSP70 interaction site [polypeptide binding]; other site 862719015479 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 862719015480 substrate binding site [polypeptide binding]; other site 862719015481 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 862719015482 Zn binding sites [ion binding]; other site 862719015483 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 862719015484 dimer interface [polypeptide binding]; other site 862719015485 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719015486 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719015487 metal binding site [ion binding]; metal-binding site 862719015488 active site 862719015489 I-site; other site 862719015490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719015491 salt bridge; other site 862719015492 non-specific DNA binding site [nucleotide binding]; other site 862719015493 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719015494 sequence-specific DNA binding site [nucleotide binding]; other site 862719015495 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 862719015496 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719015497 putative NAD(P) binding site [chemical binding]; other site 862719015498 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 862719015499 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 862719015500 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 862719015501 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719015502 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862719015503 active site 862719015504 catalytic tetrad [active] 862719015505 FIST N domain; Region: FIST; pfam08495 862719015506 FIST C domain; Region: FIST_C; pfam10442 862719015507 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 862719015508 active site 862719015509 catalytic triad [active] 862719015510 oxyanion hole [active] 862719015511 switch loop; other site 862719015512 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 862719015513 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 862719015514 Walker A/P-loop; other site 862719015515 ATP binding site [chemical binding]; other site 862719015516 Q-loop/lid; other site 862719015517 ABC transporter signature motif; other site 862719015518 Walker B; other site 862719015519 D-loop; other site 862719015520 H-loop/switch region; other site 862719015521 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 862719015522 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 862719015523 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 862719015524 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 862719015525 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 862719015526 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 862719015527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015528 active site 862719015529 phosphorylation site [posttranslational modification] 862719015530 intermolecular recognition site; other site 862719015531 dimerization interface [polypeptide binding]; other site 862719015532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719015533 DNA binding site [nucleotide binding] 862719015534 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 862719015535 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 862719015536 Walker A/P-loop; other site 862719015537 ATP binding site [chemical binding]; other site 862719015538 Q-loop/lid; other site 862719015539 ABC transporter signature motif; other site 862719015540 Walker B; other site 862719015541 D-loop; other site 862719015542 H-loop/switch region; other site 862719015543 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 862719015544 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 862719015545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719015546 dimer interface [polypeptide binding]; other site 862719015547 conserved gate region; other site 862719015548 putative PBP binding loops; other site 862719015549 ABC-ATPase subunit interface; other site 862719015550 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 862719015551 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 862719015552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719015553 dimer interface [polypeptide binding]; other site 862719015554 conserved gate region; other site 862719015555 putative PBP binding loops; other site 862719015556 ABC-ATPase subunit interface; other site 862719015557 PBP superfamily domain; Region: PBP_like_2; cl17296 862719015558 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719015559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719015560 dimer interface [polypeptide binding]; other site 862719015561 phosphorylation site [posttranslational modification] 862719015562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015563 ATP binding site [chemical binding]; other site 862719015564 Mg2+ binding site [ion binding]; other site 862719015565 G-X-G motif; other site 862719015566 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 862719015567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719015568 non-specific DNA binding site [nucleotide binding]; other site 862719015569 salt bridge; other site 862719015570 sequence-specific DNA binding site [nucleotide binding]; other site 862719015571 Cupin domain; Region: Cupin_2; pfam07883 862719015572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719015573 Coenzyme A binding pocket [chemical binding]; other site 862719015574 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 862719015575 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 862719015576 Malic enzyme, N-terminal domain; Region: malic; pfam00390 862719015577 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 862719015578 putative NAD(P) binding site [chemical binding]; other site 862719015579 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 862719015580 ribonuclease PH; Reviewed; Region: rph; PRK00173 862719015581 Ribonuclease PH; Region: RNase_PH_bact; cd11362 862719015582 hexamer interface [polypeptide binding]; other site 862719015583 active site 862719015584 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 862719015585 active site 862719015586 dimerization interface [polypeptide binding]; other site 862719015587 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 862719015588 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719015589 FeS/SAM binding site; other site 862719015590 HemN C-terminal domain; Region: HemN_C; pfam06969 862719015591 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 862719015592 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 862719015593 folate binding site [chemical binding]; other site 862719015594 NADP+ binding site [chemical binding]; other site 862719015595 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 862719015596 ParB-like nuclease domain; Region: ParB; smart00470 862719015597 KorB domain; Region: KorB; pfam08535 862719015598 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719015599 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 862719015600 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719015601 Magnesium ion binding site [ion binding]; other site 862719015602 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 862719015603 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 862719015604 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 862719015605 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 862719015606 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 862719015607 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 862719015608 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 862719015609 trmE is a tRNA modification GTPase; Region: trmE; cd04164 862719015610 G1 box; other site 862719015611 GTP/Mg2+ binding site [chemical binding]; other site 862719015612 Switch I region; other site 862719015613 G2 box; other site 862719015614 Switch II region; other site 862719015615 G3 box; other site 862719015616 G4 box; other site 862719015617 G5 box; other site 862719015618 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 862719015619 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 862719015620 dimer interface [polypeptide binding]; other site 862719015621 [2Fe-2S] cluster binding site [ion binding]; other site 862719015622 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 862719015623 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 862719015624 catalytic residues [active] 862719015625 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 862719015626 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 862719015627 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 862719015628 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 862719015629 DNA binding site [nucleotide binding] 862719015630 active site 862719015631 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 862719015632 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 862719015633 NADP binding site [chemical binding]; other site 862719015634 dimer interface [polypeptide binding]; other site 862719015635 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 862719015636 active site 862719015637 catalytic site [active] 862719015638 substrate binding site [chemical binding]; other site 862719015639 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 862719015640 dephospho-CoA kinase; Region: TIGR00152 862719015641 CoA-binding site [chemical binding]; other site 862719015642 ATP-binding [chemical binding]; other site 862719015643 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 862719015644 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 862719015645 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 862719015646 NAD(P) binding site [chemical binding]; other site 862719015647 shikimate binding site; other site 862719015648 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 862719015649 active site 862719015650 dimer interface [polypeptide binding]; other site 862719015651 PEP synthetase regulatory protein; Provisional; Region: PRK05339 862719015652 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 862719015653 substrate binding site [chemical binding]; other site 862719015654 active site 862719015655 ferrochelatase; Reviewed; Region: hemH; PRK00035 862719015656 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 862719015657 C-terminal domain interface [polypeptide binding]; other site 862719015658 active site 862719015659 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 862719015660 active site 862719015661 N-terminal domain interface [polypeptide binding]; other site 862719015662 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 862719015663 transcription termination factor Rho; Provisional; Region: rho; PRK09376 862719015664 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 862719015665 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 862719015666 RNA binding site [nucleotide binding]; other site 862719015667 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 862719015668 multimer interface [polypeptide binding]; other site 862719015669 Walker A motif; other site 862719015670 ATP binding site [chemical binding]; other site 862719015671 Walker B motif; other site 862719015672 Preprotein translocase subunit SecB; Region: SecB; pfam02556 862719015673 SecA binding site; other site 862719015674 Preprotein binding site; other site 862719015675 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 862719015676 Tim44-like domain; Region: Tim44; pfam04280 862719015677 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 862719015678 MltA specific insert domain; Region: MltA; smart00925 862719015679 3D domain; Region: 3D; pfam06725 862719015680 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 862719015681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719015682 Walker A motif; other site 862719015683 ATP binding site [chemical binding]; other site 862719015684 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 862719015685 Walker B motif; other site 862719015686 arginine finger; other site 862719015687 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 862719015688 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 862719015689 active site 862719015690 HslU subunit interaction site [polypeptide binding]; other site 862719015691 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862719015692 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 862719015693 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 862719015694 putative active site pocket [active] 862719015695 4-fold oligomerization interface [polypeptide binding]; other site 862719015696 metal binding residues [ion binding]; metal-binding site 862719015697 3-fold/trimer interface [polypeptide binding]; other site 862719015698 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 862719015699 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 862719015700 putative active site [active] 862719015701 oxyanion strand; other site 862719015702 catalytic triad [active] 862719015703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719015704 Coenzyme A binding pocket [chemical binding]; other site 862719015705 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 862719015706 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 862719015707 catalytic residues [active] 862719015708 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 862719015709 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 862719015710 substrate binding site [chemical binding]; other site 862719015711 glutamase interaction surface [polypeptide binding]; other site 862719015712 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 862719015713 metal binding site [ion binding]; metal-binding site 862719015714 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 862719015715 nucleotide binding site/active site [active] 862719015716 HIT family signature motif; other site 862719015717 catalytic residue [active] 862719015718 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719015719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719015720 non-specific DNA binding site [nucleotide binding]; other site 862719015721 salt bridge; other site 862719015722 sequence-specific DNA binding site [nucleotide binding]; other site 862719015723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 862719015724 Smr domain; Region: Smr; pfam01713 862719015725 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 862719015726 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 862719015727 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 862719015728 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 862719015729 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 862719015730 catalytic residues [active] 862719015731 central insert; other site 862719015732 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 862719015733 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 862719015734 Heme exporter protein D (CcmD); Region: CcmD; cl11475 862719015735 heme exporter protein CcmC; Region: ccmC; TIGR01191 862719015736 hypothetical protein; Provisional; Region: PRK02268 862719015737 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 862719015738 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 862719015739 putative dimer interface [polypeptide binding]; other site 862719015740 Predicted transcriptional regulator [Transcription]; Region: COG2378 862719015741 HTH domain; Region: HTH_11; pfam08279 862719015742 WYL domain; Region: WYL; pfam13280 862719015743 glucose-1-dehydrogenase; Provisional; Region: PRK06947 862719015744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719015745 NAD(P) binding site [chemical binding]; other site 862719015746 active site 862719015747 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 862719015748 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 862719015749 RNase E interface [polypeptide binding]; other site 862719015750 trimer interface [polypeptide binding]; other site 862719015751 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 862719015752 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 862719015753 RNase E interface [polypeptide binding]; other site 862719015754 trimer interface [polypeptide binding]; other site 862719015755 active site 862719015756 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 862719015757 putative nucleic acid binding region [nucleotide binding]; other site 862719015758 G-X-X-G motif; other site 862719015759 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 862719015760 RNA binding site [nucleotide binding]; other site 862719015761 domain interface; other site 862719015762 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 862719015763 16S/18S rRNA binding site [nucleotide binding]; other site 862719015764 S13e-L30e interaction site [polypeptide binding]; other site 862719015765 25S rRNA binding site [nucleotide binding]; other site 862719015766 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 862719015767 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 862719015768 RNA binding site [nucleotide binding]; other site 862719015769 active site 862719015770 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 862719015771 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 862719015772 putative active site [active] 862719015773 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 862719015774 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 862719015775 translation initiation factor IF-2; Region: IF-2; TIGR00487 862719015776 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 862719015777 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 862719015778 G1 box; other site 862719015779 putative GEF interaction site [polypeptide binding]; other site 862719015780 GTP/Mg2+ binding site [chemical binding]; other site 862719015781 Switch I region; other site 862719015782 G2 box; other site 862719015783 G3 box; other site 862719015784 Switch II region; other site 862719015785 G4 box; other site 862719015786 G5 box; other site 862719015787 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 862719015788 Translation-initiation factor 2; Region: IF-2; pfam11987 862719015789 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 862719015790 hypothetical protein; Provisional; Region: PRK09190 862719015791 Protein of unknown function (DUF448); Region: DUF448; pfam04296 862719015792 putative RNA binding cleft [nucleotide binding]; other site 862719015793 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 862719015794 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 862719015795 NusA N-terminal domain; Region: NusA_N; pfam08529 862719015796 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 862719015797 RNA binding site [nucleotide binding]; other site 862719015798 homodimer interface [polypeptide binding]; other site 862719015799 NusA-like KH domain; Region: KH_5; pfam13184 862719015800 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 862719015801 G-X-X-G motif; other site 862719015802 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 862719015803 ribosome maturation protein RimP; Reviewed; Region: PRK00092 862719015804 Sm and related proteins; Region: Sm_like; cl00259 862719015805 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 862719015806 putative oligomer interface [polypeptide binding]; other site 862719015807 putative RNA binding site [nucleotide binding]; other site 862719015808 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 862719015809 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 862719015810 S-adenosylmethionine synthetase; Validated; Region: PRK05250 862719015811 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 862719015812 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 862719015813 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 862719015814 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719015815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719015816 non-specific DNA binding site [nucleotide binding]; other site 862719015817 salt bridge; other site 862719015818 sequence-specific DNA binding site [nucleotide binding]; other site 862719015819 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 862719015820 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 862719015821 putative active site [active] 862719015822 catalytic triad [active] 862719015823 putative dimer interface [polypeptide binding]; other site 862719015824 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 862719015825 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 862719015826 Transporter associated domain; Region: CorC_HlyC; smart01091 862719015827 metal-binding heat shock protein; Provisional; Region: PRK00016 862719015828 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 862719015829 PhoH-like protein; Region: PhoH; pfam02562 862719015830 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 862719015831 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 862719015832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719015833 FeS/SAM binding site; other site 862719015834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719015835 Coenzyme A binding pocket [chemical binding]; other site 862719015836 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 862719015837 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 862719015838 GTP cyclohydrolase I; Provisional; Region: PLN03044 862719015839 active site 862719015840 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 862719015841 putative deacylase active site [active] 862719015842 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 862719015843 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 862719015844 Moco binding site; other site 862719015845 metal coordination site [ion binding]; other site 862719015846 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 862719015847 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862719015848 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 862719015849 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 862719015850 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 862719015851 minor groove reading motif; other site 862719015852 helix-hairpin-helix signature motif; other site 862719015853 substrate binding pocket [chemical binding]; other site 862719015854 active site 862719015855 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 862719015856 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 862719015857 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 862719015858 adenosine kinase; Provisional; Region: PTZ00247 862719015859 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 862719015860 substrate binding site [chemical binding]; other site 862719015861 ATP binding site [chemical binding]; other site 862719015862 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 862719015863 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 862719015864 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 862719015865 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 862719015866 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719015867 Ligand Binding Site [chemical binding]; other site 862719015868 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 862719015869 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 862719015870 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 862719015871 Response regulator receiver domain; Region: Response_reg; pfam00072 862719015872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719015873 active site 862719015874 phosphorylation site [posttranslational modification] 862719015875 intermolecular recognition site; other site 862719015876 dimerization interface [polypeptide binding]; other site 862719015877 GrpE; Region: GrpE; pfam01025 862719015878 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 862719015879 dimer interface [polypeptide binding]; other site 862719015880 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 862719015881 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 862719015882 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 862719015883 Creatinine amidohydrolase; Region: Creatininase; pfam02633 862719015884 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 862719015885 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 862719015886 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 862719015887 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 862719015888 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719015889 TAP-like protein; Region: Abhydrolase_4; pfam08386 862719015890 MarR family; Region: MarR_2; pfam12802 862719015891 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 862719015892 putative substrate binding pocket [chemical binding]; other site 862719015893 AC domain interface; other site 862719015894 catalytic triad [active] 862719015895 AB domain interface; other site 862719015896 interchain disulfide; other site 862719015897 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 862719015898 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 862719015899 active site 862719015900 HIGH motif; other site 862719015901 dimer interface [polypeptide binding]; other site 862719015902 KMSKS motif; other site 862719015903 glutathione synthetase; Provisional; Region: PRK05246 862719015904 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 862719015905 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 862719015906 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 862719015907 Tetratricopeptide repeat; Region: TPR_9; pfam13371 862719015908 hypothetical protein; Reviewed; Region: PRK12497 862719015909 Predicted methyltransferases [General function prediction only]; Region: COG0313 862719015910 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 862719015911 putative SAM binding site [chemical binding]; other site 862719015912 putative homodimer interface [polypeptide binding]; other site 862719015913 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 862719015914 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 862719015915 putative ligand binding site [chemical binding]; other site 862719015916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719015917 dimer interface [polypeptide binding]; other site 862719015918 conserved gate region; other site 862719015919 putative PBP binding loops; other site 862719015920 ABC-ATPase subunit interface; other site 862719015921 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719015922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719015923 dimer interface [polypeptide binding]; other site 862719015924 conserved gate region; other site 862719015925 putative PBP binding loops; other site 862719015926 ABC-ATPase subunit interface; other site 862719015927 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 862719015928 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719015929 substrate binding pocket [chemical binding]; other site 862719015930 membrane-bound complex binding site; other site 862719015931 hinge residues; other site 862719015932 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 862719015933 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 862719015934 Walker A/P-loop; other site 862719015935 ATP binding site [chemical binding]; other site 862719015936 Q-loop/lid; other site 862719015937 ABC transporter signature motif; other site 862719015938 Walker B; other site 862719015939 D-loop; other site 862719015940 H-loop/switch region; other site 862719015941 putative transporter; Validated; Region: PRK03818 862719015942 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 862719015943 TrkA-C domain; Region: TrkA_C; pfam02080 862719015944 TrkA-C domain; Region: TrkA_C; pfam02080 862719015945 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 862719015946 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 862719015947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719015948 Walker A/P-loop; other site 862719015949 ATP binding site [chemical binding]; other site 862719015950 Q-loop/lid; other site 862719015951 ABC transporter signature motif; other site 862719015952 Walker B; other site 862719015953 D-loop; other site 862719015954 H-loop/switch region; other site 862719015955 heme exporter protein CcmB; Region: ccmB; TIGR01190 862719015956 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 862719015957 catalytic residues [active] 862719015958 dimer interface [polypeptide binding]; other site 862719015959 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 862719015960 flagellar motor protein MotA; Validated; Region: PRK09110 862719015961 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 862719015962 Peptidase family M23; Region: Peptidase_M23; pfam01551 862719015963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719015964 binding surface 862719015965 Tetratricopeptide repeat; Region: TPR_16; pfam13432 862719015966 TPR motif; other site 862719015967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719015968 TPR motif; other site 862719015969 binding surface 862719015970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719015971 binding surface 862719015972 TPR motif; other site 862719015973 Tetratricopeptide repeat; Region: TPR_12; pfam13424 862719015974 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719015975 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862719015976 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 862719015977 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 862719015978 putative active site [active] 862719015979 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 862719015980 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 862719015981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862719015982 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 862719015983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719015984 ATP binding site [chemical binding]; other site 862719015985 Mg2+ binding site [ion binding]; other site 862719015986 G-X-G motif; other site 862719015987 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 862719015988 anchoring element; other site 862719015989 dimer interface [polypeptide binding]; other site 862719015990 ATP binding site [chemical binding]; other site 862719015991 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 862719015992 active site 862719015993 putative metal-binding site [ion binding]; other site 862719015994 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 862719015995 recombination protein F; Reviewed; Region: recF; PRK00064 862719015996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719015997 Walker A/P-loop; other site 862719015998 ATP binding site [chemical binding]; other site 862719015999 Q-loop/lid; other site 862719016000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719016001 ABC transporter signature motif; other site 862719016002 Walker B; other site 862719016003 D-loop; other site 862719016004 H-loop/switch region; other site 862719016005 DNA polymerase III subunit beta; Validated; Region: PRK05643 862719016006 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 862719016007 putative DNA binding surface [nucleotide binding]; other site 862719016008 dimer interface [polypeptide binding]; other site 862719016009 beta-clamp/clamp loader binding surface; other site 862719016010 beta-clamp/translesion DNA polymerase binding surface; other site 862719016011 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719016012 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 862719016013 putative NAD(P) binding site [chemical binding]; other site 862719016014 TPR repeat; Region: TPR_11; pfam13414 862719016015 TPR repeat; Region: TPR_11; pfam13414 862719016016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719016017 binding surface 862719016018 TPR motif; other site 862719016019 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 862719016020 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 862719016021 catalytic residues [active] 862719016022 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 862719016023 Part of AAA domain; Region: AAA_19; pfam13245 862719016024 Family description; Region: UvrD_C_2; pfam13538 862719016025 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 862719016026 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 862719016027 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 862719016028 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 862719016029 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 862719016030 Substrate binding site; other site 862719016031 metal-binding site 862719016032 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 862719016033 Phosphotransferase enzyme family; Region: APH; pfam01636 862719016034 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 862719016035 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 862719016036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 862719016037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719016038 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719016039 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 862719016040 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719016041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719016042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719016043 ABC-ATPase subunit interface; other site 862719016044 putative PBP binding loops; other site 862719016045 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 862719016046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719016047 dimer interface [polypeptide binding]; other site 862719016048 ABC-ATPase subunit interface; other site 862719016049 putative PBP binding loops; other site 862719016050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719016051 active site 862719016052 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 862719016053 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 862719016054 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 862719016055 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 862719016056 DNA binding site [nucleotide binding] 862719016057 catalytic residue [active] 862719016058 H2TH interface [polypeptide binding]; other site 862719016059 putative catalytic residues [active] 862719016060 turnover-facilitating residue; other site 862719016061 intercalation triad [nucleotide binding]; other site 862719016062 8OG recognition residue [nucleotide binding]; other site 862719016063 putative reading head residues; other site 862719016064 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 862719016065 enoyl-CoA hydratase; Provisional; Region: PRK05862 862719016066 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719016067 substrate binding site [chemical binding]; other site 862719016068 oxyanion hole (OAH) forming residues; other site 862719016069 trimer interface [polypeptide binding]; other site 862719016070 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 862719016071 transmembrane helices; other site 862719016072 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 862719016073 TrkA-C domain; Region: TrkA_C; pfam02080 862719016074 TrkA-C domain; Region: TrkA_C; pfam02080 862719016075 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 862719016076 FOG: CBS domain [General function prediction only]; Region: COG0517 862719016077 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 862719016078 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 862719016079 putative metal binding site [ion binding]; other site 862719016080 Protein of unknown function (DUF533); Region: DUF533; pfam04391 862719016081 Response regulator receiver domain; Region: Response_reg; pfam00072 862719016082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016083 active site 862719016084 phosphorylation site [posttranslational modification] 862719016085 intermolecular recognition site; other site 862719016086 dimerization interface [polypeptide binding]; other site 862719016087 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862719016088 GAF domain; Region: GAF; pfam01590 862719016089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016090 PAS domain; Region: PAS_9; pfam13426 862719016091 putative active site [active] 862719016092 heme pocket [chemical binding]; other site 862719016093 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862719016094 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016095 putative active site [active] 862719016096 heme pocket [chemical binding]; other site 862719016097 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016098 putative active site [active] 862719016099 heme pocket [chemical binding]; other site 862719016100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016101 PAS fold; Region: PAS_3; pfam08447 862719016102 putative active site [active] 862719016103 heme pocket [chemical binding]; other site 862719016104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719016105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719016106 dimer interface [polypeptide binding]; other site 862719016107 phosphorylation site [posttranslational modification] 862719016108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719016109 ATP binding site [chemical binding]; other site 862719016110 Mg2+ binding site [ion binding]; other site 862719016111 G-X-G motif; other site 862719016112 Response regulator receiver domain; Region: Response_reg; pfam00072 862719016113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016114 active site 862719016115 phosphorylation site [posttranslational modification] 862719016116 intermolecular recognition site; other site 862719016117 dimerization interface [polypeptide binding]; other site 862719016118 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719016119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016120 phosphorylation site [posttranslational modification] 862719016121 intermolecular recognition site; other site 862719016122 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 862719016123 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 862719016124 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719016125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719016126 Walker A/P-loop; other site 862719016127 ATP binding site [chemical binding]; other site 862719016128 Q-loop/lid; other site 862719016129 ABC transporter signature motif; other site 862719016130 Walker B; other site 862719016131 D-loop; other site 862719016132 H-loop/switch region; other site 862719016133 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 862719016134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862719016135 UDP-galactopyranose mutase; Region: GLF; pfam03275 862719016136 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 862719016137 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719016138 putative homodimer interface [polypeptide binding]; other site 862719016139 HupF/HypC family; Region: HupF_HypC; cl00394 862719016140 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 862719016141 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 862719016142 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 862719016143 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 862719016144 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 862719016145 nickel binding site [ion binding]; other site 862719016146 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 862719016147 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 862719016148 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 862719016149 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862719016150 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 862719016151 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 862719016152 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 862719016153 hydrogenase 4 subunit F; Validated; Region: PRK06458 862719016154 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719016155 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 862719016156 hydrogenase 4 subunit D; Validated; Region: PRK06525 862719016157 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719016158 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 862719016159 NADH dehydrogenase; Region: NADHdh; cl00469 862719016160 hydrogenase 4 subunit B; Validated; Region: PRK06521 862719016161 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 862719016162 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 862719016163 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 862719016164 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 862719016165 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 862719016166 [4Fe-4S] binding site [ion binding]; other site 862719016167 molybdopterin cofactor binding site; other site 862719016168 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 862719016169 molybdopterin cofactor binding site; other site 862719016170 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type f : factor 862719016171 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719016172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719016173 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719016174 dimerization interface [polypeptide binding]; other site 862719016175 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 862719016176 HD domain; Region: HD_4; pfam13328 862719016177 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719016178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016179 active site 862719016180 phosphorylation site [posttranslational modification] 862719016181 intermolecular recognition site; other site 862719016182 dimerization interface [polypeptide binding]; other site 862719016183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719016184 Walker A motif; other site 862719016185 ATP binding site [chemical binding]; other site 862719016186 Walker B motif; other site 862719016187 arginine finger; other site 862719016188 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719016189 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3671068; Product type pe : putative enzyme 862719016190 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719016191 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 862719016192 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 862719016193 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 862719016194 Aspartase; Region: Aspartase; cd01357 862719016195 active sites [active] 862719016196 tetramer interface [polypeptide binding]; other site 862719016197 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 862719016198 ornithine decarboxylase; Provisional; Region: PRK13578 862719016199 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719016200 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719016201 catalytic residue [active] 862719016202 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 862719016203 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 862719016204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 862719016205 Coenzyme A binding pocket [chemical binding]; other site 862719016206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 862719016207 MOSC domain; Region: MOSC; pfam03473 862719016208 3-alpha domain; Region: 3-alpha; pfam03475 862719016209 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719016210 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 862719016211 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719016212 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719016213 Fusaric acid resistance protein family; Region: FUSC; pfam04632 862719016214 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 862719016215 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 862719016216 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 862719016217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016218 putative active site [active] 862719016219 heme pocket [chemical binding]; other site 862719016220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719016221 dimer interface [polypeptide binding]; other site 862719016222 phosphorylation site [posttranslational modification] 862719016223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719016224 ATP binding site [chemical binding]; other site 862719016225 Mg2+ binding site [ion binding]; other site 862719016226 G-X-G motif; other site 862719016227 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 862719016228 hydrogenase 2 large subunit; Provisional; Region: PRK10467 862719016229 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 862719016230 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 862719016231 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 862719016232 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 862719016233 putative substrate-binding site; other site 862719016234 nickel binding site [ion binding]; other site 862719016235 HupF/HypC family; Region: HupF_HypC; pfam01455 862719016236 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 862719016237 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 862719016238 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 862719016239 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 862719016240 Rubredoxin; Region: Rubredoxin; pfam00301 862719016241 iron binding site [ion binding]; other site 862719016242 Protein of unknown function (DUF3457); Region: DUF3457; pfam11939 862719016243 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 862719016244 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 862719016245 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719016246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016247 active site 862719016248 phosphorylation site [posttranslational modification] 862719016249 intermolecular recognition site; other site 862719016250 dimerization interface [polypeptide binding]; other site 862719016251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719016252 Walker A motif; other site 862719016253 ATP binding site [chemical binding]; other site 862719016254 Walker B motif; other site 862719016255 arginine finger; other site 862719016256 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719016257 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 862719016258 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 862719016259 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 862719016260 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 862719016261 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 862719016262 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 862719016263 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 862719016264 Methyltransferase domain; Region: Methyltransf_23; pfam13489 862719016265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719016266 S-adenosylmethionine binding site [chemical binding]; other site 862719016267 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 862719016268 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 862719016269 Acylphosphatase; Region: Acylphosphatase; pfam00708 862719016270 HypF finger; Region: zf-HYPF; pfam07503 862719016271 HypF finger; Region: zf-HYPF; pfam07503 862719016272 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 862719016273 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 862719016274 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 862719016275 Sulfate transporter family; Region: Sulfate_transp; pfam00916 862719016276 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 862719016277 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 862719016278 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 862719016279 active site 862719016280 Phospholipid methyltransferase; Region: PEMT; cl17370 862719016281 short chain dehydrogenase; Provisional; Region: PRK06181 862719016282 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 862719016283 putative NAD(P) binding site [chemical binding]; other site 862719016284 active site 862719016285 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719016286 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 862719016287 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 862719016288 DctM-like transporters; Region: DctM; pfam06808 862719016289 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 862719016290 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 862719016291 putative active site [active] 862719016292 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 862719016293 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 862719016294 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 862719016295 MPT binding site; other site 862719016296 trimer interface [polypeptide binding]; other site 862719016297 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 862719016298 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 862719016299 metal ion-dependent adhesion site (MIDAS); other site 862719016300 MoxR-like ATPases [General function prediction only]; Region: COG0714 862719016301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719016302 Walker A motif; other site 862719016303 ATP binding site [chemical binding]; other site 862719016304 Walker B motif; other site 862719016305 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 862719016306 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 862719016307 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 862719016308 Low-spin heme binding site [chemical binding]; other site 862719016309 D-pathway; other site 862719016310 K-pathway; other site 862719016311 Binuclear center (active site) [active] 862719016312 Putative proton exit pathway; other site 862719016313 Putative water exit pathway; other site 862719016314 Cytochrome c; Region: Cytochrom_C; pfam00034 862719016315 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 862719016316 Subunit I/III interface [polypeptide binding]; other site 862719016317 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 862719016318 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719016319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719016320 homodimer interface [polypeptide binding]; other site 862719016321 catalytic residue [active] 862719016322 Uncharacterized conserved protein [Function unknown]; Region: COG1284 862719016323 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 862719016324 hypothetical protein; Provisional; Region: PRK01617 862719016325 SEC-C motif; Region: SEC-C; pfam02810 862719016326 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719016327 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719016328 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719016329 Zn2+ binding site [ion binding]; other site 862719016330 Mg2+ binding site [ion binding]; other site 862719016331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719016332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719016333 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719016334 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719016335 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719016336 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 862719016337 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 862719016338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719016339 S-adenosylmethionine binding site [chemical binding]; other site 862719016340 Erythromycin esterase; Region: Erythro_esteras; pfam05139 862719016341 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 862719016342 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 862719016343 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 862719016344 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 862719016345 DctM-like transporters; Region: DctM; pfam06808 862719016346 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 862719016347 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 862719016348 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 862719016349 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 862719016350 catalytic loop [active] 862719016351 iron binding site [ion binding]; other site 862719016352 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 862719016353 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 862719016354 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 862719016355 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719016356 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 862719016357 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 862719016358 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 862719016359 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 862719016360 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 862719016361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719016362 Walker A motif; other site 862719016363 ATP binding site [chemical binding]; other site 862719016364 Walker B motif; other site 862719016365 arginine finger; other site 862719016366 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 862719016367 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 862719016368 metal ion-dependent adhesion site (MIDAS); other site 862719016369 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 862719016370 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 862719016371 XdhC Rossmann domain; Region: XdhC_C; pfam13478 862719016372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719016373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719016374 ATP binding site [chemical binding]; other site 862719016375 Mg2+ binding site [ion binding]; other site 862719016376 G-X-G motif; other site 862719016377 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719016378 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 862719016379 peptide binding site [polypeptide binding]; other site 862719016380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016381 active site 862719016382 phosphorylation site [posttranslational modification] 862719016383 intermolecular recognition site; other site 862719016384 PAS fold; Region: PAS; pfam00989 862719016385 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719016386 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719016387 metal binding site [ion binding]; metal-binding site 862719016388 active site 862719016389 I-site; other site 862719016390 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 862719016391 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 862719016392 tetramer interface [polypeptide binding]; other site 862719016393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719016394 catalytic residue [active] 862719016395 MarR family; Region: MarR_2; cl17246 862719016396 Uncharacterized conserved protein [Function unknown]; Region: COG1284 862719016397 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 862719016398 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 862719016399 Putative phosphatase (DUF442); Region: DUF442; cl17385 862719016400 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 862719016401 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 862719016402 active site 862719016403 metal binding site [ion binding]; metal-binding site 862719016404 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 862719016405 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 862719016406 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 862719016407 catalytic triad [active] 862719016408 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 862719016409 putative MPT binding site; other site 862719016410 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 862719016411 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 862719016412 Ligand binding site; other site 862719016413 metal-binding site 862719016414 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 862719016415 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 862719016416 transcriptional regulator BetI; Validated; Region: PRK00767 862719016417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719016418 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 862719016419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719016420 dimer interface [polypeptide binding]; other site 862719016421 conserved gate region; other site 862719016422 putative PBP binding loops; other site 862719016423 ABC-ATPase subunit interface; other site 862719016424 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 862719016425 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 862719016426 Walker A/P-loop; other site 862719016427 ATP binding site [chemical binding]; other site 862719016428 Q-loop/lid; other site 862719016429 ABC transporter signature motif; other site 862719016430 Walker B; other site 862719016431 D-loop; other site 862719016432 H-loop/switch region; other site 862719016433 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719016434 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 862719016435 heme-binding site [chemical binding]; other site 862719016436 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719016437 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719016438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719016439 dimer interface [polypeptide binding]; other site 862719016440 putative CheW interface [polypeptide binding]; other site 862719016441 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 862719016442 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 862719016443 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 862719016444 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 862719016445 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 862719016446 homodimer interface [polypeptide binding]; other site 862719016447 substrate-cofactor binding pocket; other site 862719016448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719016449 catalytic residue [active] 862719016450 Imelysin; Region: Peptidase_M75; cl09159 862719016451 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 862719016452 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 862719016453 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 862719016454 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 862719016455 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 862719016456 Imelysin; Region: Peptidase_M75; pfam09375 862719016457 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 862719016458 S-formylglutathione hydrolase; Region: PLN02442 862719016459 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 862719016460 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 862719016461 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 862719016462 substrate binding site [chemical binding]; other site 862719016463 catalytic Zn binding site [ion binding]; other site 862719016464 NAD binding site [chemical binding]; other site 862719016465 structural Zn binding site [ion binding]; other site 862719016466 dimer interface [polypeptide binding]; other site 862719016467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719016468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719016469 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719016470 dimerization interface [polypeptide binding]; other site 862719016471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 862719016472 Protein of unknown function (DUF330); Region: DUF330; pfam03886 862719016473 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 862719016474 mce related protein; Region: MCE; pfam02470 862719016475 mce related protein; Region: MCE; pfam02470 862719016476 mce related protein; Region: MCE; pfam02470 862719016477 Paraquat-inducible protein A; Region: PqiA; pfam04403 862719016478 Paraquat-inducible protein A; Region: PqiA; pfam04403 862719016479 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 862719016480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719016481 DNA-binding site [nucleotide binding]; DNA binding site 862719016482 UTRA domain; Region: UTRA; pfam07702 862719016483 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719016484 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719016485 substrate binding pocket [chemical binding]; other site 862719016486 membrane-bound complex binding site; other site 862719016487 hinge residues; other site 862719016488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 862719016489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719016490 dimer interface [polypeptide binding]; other site 862719016491 ABC-ATPase subunit interface; other site 862719016492 putative PBP binding loops; other site 862719016493 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719016494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719016495 dimer interface [polypeptide binding]; other site 862719016496 conserved gate region; other site 862719016497 putative PBP binding loops; other site 862719016498 ABC-ATPase subunit interface; other site 862719016499 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719016500 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 862719016501 Walker A/P-loop; other site 862719016502 ATP binding site [chemical binding]; other site 862719016503 Q-loop/lid; other site 862719016504 ABC transporter signature motif; other site 862719016505 Walker B; other site 862719016506 D-loop; other site 862719016507 H-loop/switch region; other site 862719016508 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 862719016509 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 862719016510 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 862719016511 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 862719016512 Walker A/P-loop; other site 862719016513 ATP binding site [chemical binding]; other site 862719016514 Q-loop/lid; other site 862719016515 ABC transporter signature motif; other site 862719016516 Walker B; other site 862719016517 D-loop; other site 862719016518 H-loop/switch region; other site 862719016519 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 862719016520 BioY family; Region: BioY; pfam02632 862719016521 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 862719016522 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719016523 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 862719016524 acyl-activating enzyme (AAE) consensus motif; other site 862719016525 acyl-activating enzyme (AAE) consensus motif; other site 862719016526 AMP binding site [chemical binding]; other site 862719016527 active site 862719016528 CoA binding site [chemical binding]; other site 862719016529 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 862719016530 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719016531 dimer interface [polypeptide binding]; other site 862719016532 active site 862719016533 H+ Antiporter protein; Region: 2A0121; TIGR00900 862719016534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719016535 putative substrate translocation pore; other site 862719016536 phosphoribosylglycinamide formyltransferase 2; Region: purT; TIGR01142 862719016537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719016538 ATP-grasp domain; Region: ATP-grasp; pfam02222 862719016539 Response regulator receiver domain; Region: Response_reg; pfam00072 862719016540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016541 active site 862719016542 phosphorylation site [posttranslational modification] 862719016543 intermolecular recognition site; other site 862719016544 dimerization interface [polypeptide binding]; other site 862719016545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016546 PAS fold; Region: PAS_3; pfam08447 862719016547 putative active site [active] 862719016548 heme pocket [chemical binding]; other site 862719016549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719016550 dimer interface [polypeptide binding]; other site 862719016551 phosphorylation site [posttranslational modification] 862719016552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719016553 ATP binding site [chemical binding]; other site 862719016554 Mg2+ binding site [ion binding]; other site 862719016555 G-X-G motif; other site 862719016556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 862719016557 phosphorylation site [posttranslational modification] 862719016558 intermolecular recognition site; other site 862719016559 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719016560 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719016561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719016562 dimerization interface [polypeptide binding]; other site 862719016563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719016564 dimerization interface [polypeptide binding]; other site 862719016565 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719016566 dimerization interface [polypeptide binding]; other site 862719016567 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719016568 dimerization interface [polypeptide binding]; other site 862719016569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719016570 dimerization interface [polypeptide binding]; other site 862719016571 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 862719016572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719016573 dimerization interface [polypeptide binding]; other site 862719016574 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719016575 dimerization interface [polypeptide binding]; other site 862719016576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719016577 dimerization interface [polypeptide binding]; other site 862719016578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719016579 dimerization interface [polypeptide binding]; other site 862719016580 GAF domain; Region: GAF_2; pfam13185 862719016581 GAF domain; Region: GAF; pfam01590 862719016582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719016583 dimer interface [polypeptide binding]; other site 862719016584 phosphorylation site [posttranslational modification] 862719016585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719016586 ATP binding site [chemical binding]; other site 862719016587 Mg2+ binding site [ion binding]; other site 862719016588 G-X-G motif; other site 862719016589 Response regulator receiver domain; Region: Response_reg; pfam00072 862719016590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016591 active site 862719016592 phosphorylation site [posttranslational modification] 862719016593 intermolecular recognition site; other site 862719016594 dimerization interface [polypeptide binding]; other site 862719016595 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719016596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016597 active site 862719016598 phosphorylation site [posttranslational modification] 862719016599 intermolecular recognition site; other site 862719016600 Response regulator receiver domain; Region: Response_reg; pfam00072 862719016601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016602 active site 862719016603 phosphorylation site [posttranslational modification] 862719016604 intermolecular recognition site; other site 862719016605 dimerization interface [polypeptide binding]; other site 862719016606 TMAO/DMSO reductase; Reviewed; Region: PRK05363 862719016607 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 862719016608 Moco binding site; other site 862719016609 metal coordination site [ion binding]; other site 862719016610 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 862719016611 Dienelactone hydrolase family; Region: DLH; pfam01738 862719016612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719016613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719016614 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 862719016615 dimerization interface [polypeptide binding]; other site 862719016616 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 862719016617 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 862719016618 dimer interface [polypeptide binding]; other site 862719016619 active site 862719016620 heme binding site [chemical binding]; other site 862719016621 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 862719016622 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 862719016623 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 862719016624 S4 RNA-binding domain; Region: S4; smart00363 862719016625 RNA binding surface [nucleotide binding]; other site 862719016626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719016627 S-adenosylmethionine binding site [chemical binding]; other site 862719016628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719016629 Histidine kinase; Region: HisKA_2; pfam07568 862719016630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719016631 ATP binding site [chemical binding]; other site 862719016632 Mg2+ binding site [ion binding]; other site 862719016633 G-X-G motif; other site 862719016634 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 862719016635 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 862719016636 TPP-binding site; other site 862719016637 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 862719016638 PYR/PP interface [polypeptide binding]; other site 862719016639 dimer interface [polypeptide binding]; other site 862719016640 TPP binding site [chemical binding]; other site 862719016641 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719016642 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 862719016643 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 862719016644 substrate binding pocket [chemical binding]; other site 862719016645 chain length determination region; other site 862719016646 substrate-Mg2+ binding site; other site 862719016647 catalytic residues [active] 862719016648 aspartate-rich region 1; other site 862719016649 active site lid residues [active] 862719016650 aspartate-rich region 2; other site 862719016651 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 862719016652 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 862719016653 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 862719016654 putative active site [active] 862719016655 Zn binding site [ion binding]; other site 862719016656 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 862719016657 CPxP motif; other site 862719016658 Predicted transcriptional regulators [Transcription]; Region: COG1733 862719016659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 862719016660 dimerization interface [polypeptide binding]; other site 862719016661 putative DNA binding site [nucleotide binding]; other site 862719016662 putative Zn2+ binding site [ion binding]; other site 862719016663 Protein of unknown function (DUF423); Region: DUF423; pfam04241 862719016664 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 862719016665 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719016666 active site 862719016667 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 862719016668 Amidase; Region: Amidase; cl11426 862719016669 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 862719016670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719016671 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719016672 NAD(P) binding site [chemical binding]; other site 862719016673 active site 862719016674 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 862719016675 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719016676 catalytic residue [active] 862719016677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016678 PAS domain; Region: PAS_9; pfam13426 862719016679 putative active site [active] 862719016680 heme pocket [chemical binding]; other site 862719016681 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719016682 PAS domain S-box; Region: sensory_box; TIGR00229 862719016683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016684 putative active site [active] 862719016685 heme pocket [chemical binding]; other site 862719016686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016687 PAS domain; Region: PAS_9; pfam13426 862719016688 putative active site [active] 862719016689 heme pocket [chemical binding]; other site 862719016690 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719016691 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719016692 metal binding site [ion binding]; metal-binding site 862719016693 active site 862719016694 I-site; other site 862719016695 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719016696 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 862719016697 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 862719016698 active site 862719016699 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 862719016700 Catalytic domain of Protein Kinases; Region: PKc; cd00180 862719016701 active site 862719016702 ATP binding site [chemical binding]; other site 862719016703 substrate binding site [chemical binding]; other site 862719016704 activation loop (A-loop); other site 862719016705 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 862719016706 Zinc-finger domain; Region: zf-CHCC; cl01821 862719016707 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 862719016708 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 862719016709 Walker A/P-loop; other site 862719016710 ATP binding site [chemical binding]; other site 862719016711 Q-loop/lid; other site 862719016712 ABC transporter signature motif; other site 862719016713 Walker B; other site 862719016714 D-loop; other site 862719016715 H-loop/switch region; other site 862719016716 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 862719016717 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 862719016718 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 862719016719 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 862719016720 active site 862719016721 catalytic site [active] 862719016722 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 862719016723 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 862719016724 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 862719016725 active site 862719016726 homodimer interface [polypeptide binding]; other site 862719016727 catalytic site [active] 862719016728 acceptor binding site [chemical binding]; other site 862719016729 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 862719016730 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 862719016731 aspartate racemase; Region: asp_race; TIGR00035 862719016732 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719016733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719016734 active site 862719016735 phosphorylation site [posttranslational modification] 862719016736 intermolecular recognition site; other site 862719016737 dimerization interface [polypeptide binding]; other site 862719016738 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719016739 DNA binding residues [nucleotide binding] 862719016740 dimerization interface [polypeptide binding]; other site 862719016741 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016742 PAS domain; Region: PAS_9; pfam13426 862719016743 putative active site [active] 862719016744 heme pocket [chemical binding]; other site 862719016745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719016746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719016747 dimer interface [polypeptide binding]; other site 862719016748 phosphorylation site [posttranslational modification] 862719016749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719016750 ATP binding site [chemical binding]; other site 862719016751 Mg2+ binding site [ion binding]; other site 862719016752 G-X-G motif; other site 862719016753 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 862719016754 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 862719016755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016756 PAS domain; Region: PAS_9; pfam13426 862719016757 putative active site [active] 862719016758 heme pocket [chemical binding]; other site 862719016759 PAS domain; Region: PAS; smart00091 862719016760 PAS domain; Region: PAS_9; pfam13426 862719016761 PAS domain; Region: PAS_9; pfam13426 862719016762 CheB methylesterase; Region: CheB_methylest; pfam01339 862719016763 Domain of unknown function (DUF892); Region: DUF892; pfam05974 862719016764 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 862719016765 Protein of unknown function (DUF533); Region: DUF533; pfam04391 862719016766 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 862719016767 putative metal binding site [ion binding]; other site 862719016768 Predicted membrane protein [Function unknown]; Region: COG4325 862719016769 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 862719016770 Peptidase propeptide and YPEB domain; Region: PepSY_2; cl17877 862719016771 Predicted membrane protein [Function unknown]; Region: COG2323 862719016772 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 862719016773 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 862719016774 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 862719016775 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 862719016776 Surface antigen; Region: Bac_surface_Ag; pfam01103 862719016777 CHASE2 domain; Region: CHASE2; pfam05226 862719016778 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 862719016779 cyclase homology domain; Region: CHD; cd07302 862719016780 nucleotidyl binding site; other site 862719016781 metal binding site [ion binding]; metal-binding site 862719016782 dimer interface [polypeptide binding]; other site 862719016783 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 862719016784 PhoU domain; Region: PhoU; pfam01895 862719016785 PhoU domain; Region: PhoU; pfam01895 862719016786 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 862719016787 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 862719016788 motif 1; other site 862719016789 dimer interface [polypeptide binding]; other site 862719016790 active site 862719016791 motif 2; other site 862719016792 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 862719016793 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 862719016794 GDP-binding site [chemical binding]; other site 862719016795 ACT binding site; other site 862719016796 IMP binding site; other site 862719016797 Rrf2 family protein; Region: rrf2_super; TIGR00738 862719016798 Transcriptional regulator; Region: Rrf2; pfam02082 862719016799 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 862719016800 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 862719016801 ParB-like nuclease domain; Region: ParB; smart00470 862719016802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719016803 S-adenosylmethionine binding site [chemical binding]; other site 862719016804 Methyltransferase domain; Region: Methyltransf_24; pfam13578 862719016805 malate synthase G; Provisional; Region: PRK02999 862719016806 active site 862719016807 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 862719016808 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 862719016809 Transcriptional regulator; Region: Rrf2; pfam02082 862719016810 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 862719016811 putative ABC transporter; Region: ycf24; CHL00085 862719016812 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 862719016813 GIY-YIG motif/motif A; other site 862719016814 putative active site [active] 862719016815 putative metal binding site [ion binding]; other site 862719016816 FeS assembly ATPase SufC; Region: sufC; TIGR01978 862719016817 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 862719016818 Walker A/P-loop; other site 862719016819 ATP binding site [chemical binding]; other site 862719016820 Q-loop/lid; other site 862719016821 ABC transporter signature motif; other site 862719016822 Walker B; other site 862719016823 D-loop; other site 862719016824 H-loop/switch region; other site 862719016825 FeS assembly protein SufD; Region: sufD; TIGR01981 862719016826 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 862719016827 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 862719016828 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 862719016829 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719016830 catalytic residue [active] 862719016831 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 862719016832 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 862719016833 trimerization site [polypeptide binding]; other site 862719016834 active site 862719016835 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 862719016836 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 862719016837 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719016838 Winged helix-turn helix; Region: HTH_29; pfam13551 862719016839 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719016840 Homeodomain-like domain; Region: HTH_32; pfam13565 862719016841 Pirin-related protein [General function prediction only]; Region: COG1741 862719016842 Pirin; Region: Pirin; pfam02678 862719016843 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 862719016844 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 862719016845 PAS fold; Region: PAS; pfam00989 862719016846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016847 putative active site [active] 862719016848 heme pocket [chemical binding]; other site 862719016849 PAS domain S-box; Region: sensory_box; TIGR00229 862719016850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719016851 putative active site [active] 862719016852 heme pocket [chemical binding]; other site 862719016853 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719016854 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719016855 metal binding site [ion binding]; metal-binding site 862719016856 active site 862719016857 I-site; other site 862719016858 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719016859 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 862719016860 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 862719016861 dimerization interface [polypeptide binding]; other site 862719016862 ligand binding site [chemical binding]; other site 862719016863 Transcriptional regulator [Transcription]; Region: IclR; COG1414 862719016864 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 862719016865 Bacterial transcriptional regulator; Region: IclR; pfam01614 862719016866 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 862719016867 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 862719016868 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 862719016869 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 862719016870 active site 862719016871 intersubunit interface [polypeptide binding]; other site 862719016872 catalytic residue [active] 862719016873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 862719016874 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 862719016875 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 862719016876 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 862719016877 classical (c) SDRs; Region: SDR_c; cd05233 862719016878 NAD(P) binding site [chemical binding]; other site 862719016879 active site 862719016880 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719016881 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719016882 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 862719016883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719016884 non-specific DNA binding site [nucleotide binding]; other site 862719016885 salt bridge; other site 862719016886 sequence-specific DNA binding site [nucleotide binding]; other site 862719016887 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 862719016888 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 862719016889 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 862719016890 substrate binding site [chemical binding]; other site 862719016891 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 862719016892 substrate binding site [chemical binding]; other site 862719016893 ligand binding site [chemical binding]; other site 862719016894 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 862719016895 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719016896 EamA-like transporter family; Region: EamA; pfam00892 862719016897 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 862719016898 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719016899 FeS/SAM binding site; other site 862719016900 Agmatinase-like family; Region: Agmatinase-like; cd09990 862719016901 agmatinase; Region: agmatinase; TIGR01230 862719016902 active site 862719016903 oligomer interface [polypeptide binding]; other site 862719016904 Mn binding site [ion binding]; other site 862719016905 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 862719016906 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862719016907 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 862719016908 putative active site [active] 862719016909 Pyruvate formate lyase 1; Region: PFL1; cd01678 862719016910 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 862719016911 coenzyme A binding site [chemical binding]; other site 862719016912 active site 862719016913 catalytic residues [active] 862719016914 glycine loop; other site 862719016915 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 862719016916 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719016917 FeS/SAM binding site; other site 862719016918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 862719016919 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 862719016920 FAD binding domain; Region: FAD_binding_4; pfam01565 862719016921 Berberine and berberine like; Region: BBE; pfam08031 862719016922 Transcriptional regulators [Transcription]; Region: PurR; COG1609 862719016923 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719016924 DNA binding site [nucleotide binding] 862719016925 domain linker motif; other site 862719016926 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 862719016927 putative dimerization interface [polypeptide binding]; other site 862719016928 putative ligand binding site [chemical binding]; other site 862719016929 altronate oxidoreductase; Provisional; Region: PRK03643 862719016930 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 862719016931 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 862719016932 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 862719016933 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 862719016934 dimer interface [polypeptide binding]; other site 862719016935 PYR/PP interface [polypeptide binding]; other site 862719016936 TPP binding site [chemical binding]; other site 862719016937 substrate binding site [chemical binding]; other site 862719016938 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 862719016939 Domain of unknown function; Region: EKR; pfam10371 862719016940 4Fe-4S binding domain; Region: Fer4; pfam00037 862719016941 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 862719016942 TPP-binding site [chemical binding]; other site 862719016943 dimer interface [polypeptide binding]; other site 862719016944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719016945 D-galactonate transporter; Region: 2A0114; TIGR00893 862719016946 putative substrate translocation pore; other site 862719016947 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 862719016948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 862719016949 motif II; other site 862719016950 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 862719016951 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 862719016952 alpha-amylase; Reviewed; Region: malS; PRK09505 862719016953 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 862719016954 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 862719016955 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719016956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719016957 Walker A/P-loop; other site 862719016958 ATP binding site [chemical binding]; other site 862719016959 Q-loop/lid; other site 862719016960 ABC transporter signature motif; other site 862719016961 Walker B; other site 862719016962 D-loop; other site 862719016963 H-loop/switch region; other site 862719016964 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 862719016965 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 862719016966 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719016967 Walker A/P-loop; other site 862719016968 ATP binding site [chemical binding]; other site 862719016969 Q-loop/lid; other site 862719016970 ABC transporter signature motif; other site 862719016971 Walker B; other site 862719016972 D-loop; other site 862719016973 H-loop/switch region; other site 862719016974 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 862719016975 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719016976 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 862719016977 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719016978 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719016979 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719016980 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 862719016981 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 862719016982 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 862719016983 Beta-lactamase; Region: Beta-lactamase; pfam00144 862719016984 DNA polymerase I; Provisional; Region: PRK05755 862719016985 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 862719016986 active site 862719016987 metal binding site 1 [ion binding]; metal-binding site 862719016988 putative 5' ssDNA interaction site; other site 862719016989 metal binding site 3; metal-binding site 862719016990 metal binding site 2 [ion binding]; metal-binding site 862719016991 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 862719016992 putative DNA binding site [nucleotide binding]; other site 862719016993 putative metal binding site [ion binding]; other site 862719016994 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 862719016995 active site 862719016996 catalytic site [active] 862719016997 substrate binding site [chemical binding]; other site 862719016998 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 862719016999 active site 862719017000 DNA binding site [nucleotide binding] 862719017001 catalytic site [active] 862719017002 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719017003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719017004 active site 862719017005 phosphorylation site [posttranslational modification] 862719017006 intermolecular recognition site; other site 862719017007 dimerization interface [polypeptide binding]; other site 862719017008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719017009 DNA binding site [nucleotide binding] 862719017010 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 862719017011 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719017012 substrate binding pocket [chemical binding]; other site 862719017013 membrane-bound complex binding site; other site 862719017014 hinge residues; other site 862719017015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719017016 dimerization interface [polypeptide binding]; other site 862719017017 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 862719017018 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 862719017019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719017020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719017021 dimer interface [polypeptide binding]; other site 862719017022 phosphorylation site [posttranslational modification] 862719017023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719017024 ATP binding site [chemical binding]; other site 862719017025 Mg2+ binding site [ion binding]; other site 862719017026 G-X-G motif; other site 862719017027 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719017028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719017029 metal binding site [ion binding]; metal-binding site 862719017030 active site 862719017031 I-site; other site 862719017032 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 862719017033 Domain of unknown function DUF20; Region: UPF0118; pfam01594 862719017034 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 862719017035 agmatine deiminase; Region: agmatine_aguA; TIGR03380 862719017036 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 862719017037 Sulfatase; Region: Sulfatase; cl17466 862719017038 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 862719017039 Sulfatase; Region: Sulfatase; cl17466 862719017040 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719017041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719017042 dimer interface [polypeptide binding]; other site 862719017043 conserved gate region; other site 862719017044 putative PBP binding loops; other site 862719017045 ABC-ATPase subunit interface; other site 862719017046 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 862719017047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719017048 dimer interface [polypeptide binding]; other site 862719017049 conserved gate region; other site 862719017050 putative PBP binding loops; other site 862719017051 ABC-ATPase subunit interface; other site 862719017052 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 862719017053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 862719017054 Walker A/P-loop; other site 862719017055 ATP binding site [chemical binding]; other site 862719017056 Q-loop/lid; other site 862719017057 ABC transporter signature motif; other site 862719017058 Walker B; other site 862719017059 D-loop; other site 862719017060 H-loop/switch region; other site 862719017061 TOBE domain; Region: TOBE_2; pfam08402 862719017062 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 862719017063 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 862719017064 Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913 862719017065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719017066 FeS/SAM binding site; other site 862719017067 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 862719017068 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 862719017069 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 862719017070 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 862719017071 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 862719017072 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 862719017073 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 862719017074 hypothetical protein; Validated; Region: PRK08238 862719017075 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 862719017076 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 862719017077 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 862719017078 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 862719017079 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 862719017080 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 862719017081 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719017082 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 862719017083 AAA domain; Region: AAA_23; pfam13476 862719017084 Walker A/P-loop; other site 862719017085 ATP binding site [chemical binding]; other site 862719017086 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 862719017087 ABC transporter signature motif; other site 862719017088 Walker B; other site 862719017089 D-loop; other site 862719017090 H-loop/switch region; other site 862719017091 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 862719017092 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 862719017093 catalytic residues [active] 862719017094 Protein of unknown function (DUF721); Region: DUF721; cl02324 862719017095 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 862719017096 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 862719017097 minor groove reading motif; other site 862719017098 helix-hairpin-helix signature motif; other site 862719017099 substrate binding pocket [chemical binding]; other site 862719017100 active site 862719017101 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 862719017102 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 862719017103 DNA binding and oxoG recognition site [nucleotide binding] 862719017104 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 862719017105 metal ion-dependent adhesion site (MIDAS); other site 862719017106 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 862719017107 hydroxyglutarate oxidase; Provisional; Region: PRK11728 862719017108 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 862719017109 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 862719017110 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719017111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719017112 active site 862719017113 phosphorylation site [posttranslational modification] 862719017114 intermolecular recognition site; other site 862719017115 dimerization interface [polypeptide binding]; other site 862719017116 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719017117 dimerization interface [polypeptide binding]; other site 862719017118 DNA binding residues [nucleotide binding] 862719017119 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 862719017120 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 862719017121 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719017122 active site 862719017123 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 862719017124 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 862719017125 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 862719017126 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719017127 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719017128 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 862719017129 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719017130 substrate binding site [chemical binding]; other site 862719017131 oxyanion hole (OAH) forming residues; other site 862719017132 trimer interface [polypeptide binding]; other site 862719017133 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 862719017134 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 862719017135 dimer interface [polypeptide binding]; other site 862719017136 active site 862719017137 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 862719017138 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 862719017139 DNA binding residues [nucleotide binding] 862719017140 putative dimer interface [polypeptide binding]; other site 862719017141 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 862719017142 MG2 domain; Region: A2M_N; pfam01835 862719017143 Alpha-2-macroglobulin family; Region: A2M; pfam00207 862719017144 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 862719017145 surface patch; other site 862719017146 thioester region; other site 862719017147 specificity defining residues; other site 862719017148 hypothetical protein; Provisional; Region: PRK08912 862719017149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719017150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719017151 homodimer interface [polypeptide binding]; other site 862719017152 catalytic residue [active] 862719017153 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719017154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719017155 dimer interface [polypeptide binding]; other site 862719017156 putative CheW interface [polypeptide binding]; other site 862719017157 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 862719017158 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : putative transporter 862719017159 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 862719017160 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 862719017161 EamA-like transporter family; Region: EamA; pfam00892 862719017162 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719017163 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719017164 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 862719017165 putative DNA binding site [nucleotide binding]; other site 862719017166 putative Zn2+ binding site [ion binding]; other site 862719017167 AsnC family; Region: AsnC_trans_reg; pfam01037 862719017168 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 862719017169 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 862719017170 putative NAD(P) binding site [chemical binding]; other site 862719017171 catalytic Zn binding site [ion binding]; other site 862719017172 structural Zn binding site [ion binding]; other site 862719017173 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 862719017174 CoA-transferase family III; Region: CoA_transf_3; pfam02515 862719017175 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 862719017176 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 862719017177 inhibitor-cofactor binding pocket; inhibition site 862719017178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719017179 catalytic residue [active] 862719017180 succinic semialdehyde dehydrogenase; Region: PLN02278 862719017181 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 862719017182 tetramerization interface [polypeptide binding]; other site 862719017183 NAD(P) binding site [chemical binding]; other site 862719017184 catalytic residues [active] 862719017185 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 862719017186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719017187 non-specific DNA binding site [nucleotide binding]; other site 862719017188 salt bridge; other site 862719017189 sequence-specific DNA binding site [nucleotide binding]; other site 862719017190 Cupin domain; Region: Cupin_2; pfam07883 862719017191 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719017192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719017193 dimer interface [polypeptide binding]; other site 862719017194 conserved gate region; other site 862719017195 putative PBP binding loops; other site 862719017196 ABC-ATPase subunit interface; other site 862719017197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719017198 dimer interface [polypeptide binding]; other site 862719017199 conserved gate region; other site 862719017200 putative PBP binding loops; other site 862719017201 ABC-ATPase subunit interface; other site 862719017202 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 862719017203 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 862719017204 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 862719017205 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 862719017206 Walker A/P-loop; other site 862719017207 ATP binding site [chemical binding]; other site 862719017208 Q-loop/lid; other site 862719017209 ABC transporter signature motif; other site 862719017210 Walker B; other site 862719017211 D-loop; other site 862719017212 H-loop/switch region; other site 862719017213 TOBE domain; Region: TOBE_2; pfam08402 862719017214 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 862719017215 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 862719017216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 862719017217 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 862719017218 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 862719017219 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 862719017220 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 862719017221 active site 862719017222 catalytic site [active] 862719017223 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 862719017224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719017225 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 862719017226 dimerization interface [polypeptide binding]; other site 862719017227 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 862719017228 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 862719017229 tetramer interface [polypeptide binding]; other site 862719017230 heme binding pocket [chemical binding]; other site 862719017231 NADPH binding site [chemical binding]; other site 862719017232 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 862719017233 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862719017234 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719017235 catalytic residue [active] 862719017236 Sporulation related domain; Region: SPOR; pfam05036 862719017237 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 862719017238 GAF domain; Region: GAF; pfam01590 862719017239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719017240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719017241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 862719017242 dimerization interface [polypeptide binding]; other site 862719017243 acetylornithine deacetylase; Provisional; Region: PRK06837 862719017244 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 862719017245 metal binding site [ion binding]; metal-binding site 862719017246 dimer interface [polypeptide binding]; other site 862719017247 aldolase II superfamily protein; Provisional; Region: PRK07044 862719017248 intersubunit interface [polypeptide binding]; other site 862719017249 active site 862719017250 Zn2+ binding site [ion binding]; other site 862719017251 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 862719017252 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 862719017253 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 862719017254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719017255 dimer interface [polypeptide binding]; other site 862719017256 conserved gate region; other site 862719017257 putative PBP binding loops; other site 862719017258 ABC-ATPase subunit interface; other site 862719017259 dipeptide transporter; Provisional; Region: PRK10913 862719017260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719017261 dimer interface [polypeptide binding]; other site 862719017262 conserved gate region; other site 862719017263 putative PBP binding loops; other site 862719017264 ABC-ATPase subunit interface; other site 862719017265 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 862719017266 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719017267 Walker A/P-loop; other site 862719017268 ATP binding site [chemical binding]; other site 862719017269 Q-loop/lid; other site 862719017270 ABC transporter signature motif; other site 862719017271 Walker B; other site 862719017272 D-loop; other site 862719017273 H-loop/switch region; other site 862719017274 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 862719017275 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 862719017276 Walker A/P-loop; other site 862719017277 ATP binding site [chemical binding]; other site 862719017278 Q-loop/lid; other site 862719017279 ABC transporter signature motif; other site 862719017280 Walker B; other site 862719017281 D-loop; other site 862719017282 H-loop/switch region; other site 862719017283 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 862719017284 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 862719017285 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 862719017286 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 862719017287 allantoate amidohydrolase; Reviewed; Region: PRK12893 862719017288 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 862719017289 active site 862719017290 metal binding site [ion binding]; metal-binding site 862719017291 dimer interface [polypeptide binding]; other site 862719017292 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 862719017293 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 862719017294 active site 862719017295 Zn binding site [ion binding]; other site 862719017296 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 862719017297 EamA-like transporter family; Region: EamA; pfam00892 862719017298 EamA-like transporter family; Region: EamA; cl17759 862719017299 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 862719017300 beta-galactosidase; Region: BGL; TIGR03356 862719017301 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 862719017302 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 862719017303 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 862719017304 catalytic residues [active] 862719017305 catalytic nucleophile [active] 862719017306 Presynaptic Site I dimer interface [polypeptide binding]; other site 862719017307 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 862719017308 Synaptic Flat tetramer interface [polypeptide binding]; other site 862719017309 Synaptic Site I dimer interface [polypeptide binding]; other site 862719017310 DNA binding site [nucleotide binding] 862719017311 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 862719017312 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719017313 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862719017314 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 862719017315 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719017316 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719017317 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 862719017318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719017319 salt bridge; other site 862719017320 non-specific DNA binding site [nucleotide binding]; other site 862719017321 sequence-specific DNA binding site [nucleotide binding]; other site 862719017322 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 862719017323 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 862719017324 dimer interface [polypeptide binding]; other site 862719017325 PYR/PP interface [polypeptide binding]; other site 862719017326 TPP binding site [chemical binding]; other site 862719017327 substrate binding site [chemical binding]; other site 862719017328 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 862719017329 TPP-binding site [chemical binding]; other site 862719017330 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 862719017331 TPR repeat; Region: TPR_11; pfam13414 862719017332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719017333 TPR motif; other site 862719017334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719017335 TPR repeat; Region: TPR_11; pfam13414 862719017336 binding surface 862719017337 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 862719017338 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 862719017339 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 862719017340 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 862719017341 DXD motif; other site 862719017342 PilZ domain; Region: PilZ; pfam07238 862719017343 Predicted permeases [General function prediction only]; Region: COG0679 862719017344 OsmC-like protein; Region: OsmC; cl00767 862719017345 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 862719017346 putative FMN binding site [chemical binding]; other site 862719017347 NAD synthetase; Reviewed; Region: nadE; PRK02628 862719017348 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 862719017349 multimer interface [polypeptide binding]; other site 862719017350 active site 862719017351 catalytic triad [active] 862719017352 protein interface 1 [polypeptide binding]; other site 862719017353 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 862719017354 homodimer interface [polypeptide binding]; other site 862719017355 NAD binding pocket [chemical binding]; other site 862719017356 ATP binding pocket [chemical binding]; other site 862719017357 Mg binding site [ion binding]; other site 862719017358 active-site loop [active] 862719017359 Flagellar protein FlaF; Region: FlaF; pfam07309 862719017360 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 862719017361 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 862719017362 putative active site [active] 862719017363 Predicted permeases [General function prediction only]; Region: COG0795 862719017364 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 862719017365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719017366 TPR motif; other site 862719017367 TPR repeat; Region: TPR_11; pfam13414 862719017368 binding surface 862719017369 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 862719017370 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 862719017371 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 862719017372 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 862719017373 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 862719017374 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 862719017375 catalytic residue [active] 862719017376 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 862719017377 putative active site [active] 862719017378 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719017379 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 862719017380 P-loop; other site 862719017381 Magnesium ion binding site [ion binding]; other site 862719017382 Helix-turn-helix domain; Region: HTH_36; pfam13730 862719017383 N-formylglutamate amidohydrolase; Region: FGase; cl01522 862719017384 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 862719017385 active sites [active] 862719017386 tetramer interface [polypeptide binding]; other site 862719017387 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 862719017388 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719017389 active site 862719017390 imidazolonepropionase; Validated; Region: PRK09356 862719017391 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 862719017392 active site 862719017393 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 862719017394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719017395 DNA-binding site [nucleotide binding]; DNA binding site 862719017396 UTRA domain; Region: UTRA; pfam07702 862719017397 urocanate hydratase; Provisional; Region: PRK05414 862719017398 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 862719017399 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 862719017400 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 862719017401 homodimer interface [polypeptide binding]; other site 862719017402 substrate-cofactor binding pocket; other site 862719017403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719017404 catalytic residue [active] 862719017405 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 862719017406 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 862719017407 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 862719017408 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 862719017409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719017410 NAD(P) binding site [chemical binding]; other site 862719017411 active site 862719017412 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 862719017413 Clp amino terminal domain; Region: Clp_N; pfam02861 862719017414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719017415 Walker A motif; other site 862719017416 ATP binding site [chemical binding]; other site 862719017417 Walker B motif; other site 862719017418 arginine finger; other site 862719017419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719017420 Walker A motif; other site 862719017421 ATP binding site [chemical binding]; other site 862719017422 Walker B motif; other site 862719017423 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 862719017424 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 862719017425 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 862719017426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719017427 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 862719017428 putative dimerization interface [polypeptide binding]; other site 862719017429 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 862719017430 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719017431 ligand binding site [chemical binding]; other site 862719017432 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 862719017433 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 862719017434 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 862719017435 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719017436 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719017437 ligand binding site [chemical binding]; other site 862719017438 flexible hinge region; other site 862719017439 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 862719017440 EamA-like transporter family; Region: EamA; pfam00892 862719017441 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 862719017442 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 862719017443 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 862719017444 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719017445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719017446 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719017447 putative effector binding pocket; other site 862719017448 dimerization interface [polypeptide binding]; other site 862719017449 choline dehydrogenase; Validated; Region: PRK02106 862719017450 lycopene cyclase; Region: lycopene_cycl; TIGR01789 862719017451 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 862719017452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 862719017453 Transposase; Region: DEDD_Tnp_IS110; pfam01548 862719017454 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 862719017455 Caspase domain; Region: Peptidase_C14; pfam00656 862719017456 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 862719017457 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 862719017458 structural tetrad; other site 862719017459 FOG: WD40 repeat [General function prediction only]; Region: COG2319 862719017460 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 862719017461 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 862719017462 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719017463 ligand binding site [chemical binding]; other site 862719017464 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 862719017465 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 862719017466 G1 box; other site 862719017467 GTP/Mg2+ binding site [chemical binding]; other site 862719017468 G2 box; other site 862719017469 G3 box; other site 862719017470 Switch II region; other site 862719017471 G4 box; other site 862719017472 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 862719017473 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 862719017474 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 862719017475 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 862719017476 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 862719017477 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 862719017478 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 862719017479 Uncharacterized conserved protein [Function unknown]; Region: COG4104 862719017480 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 862719017481 phosphopeptide binding site; other site 862719017482 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 862719017483 Catalytic domain of Protein Kinases; Region: PKc; cd00180 862719017484 active site 862719017485 ATP binding site [chemical binding]; other site 862719017486 substrate binding site [chemical binding]; other site 862719017487 activation loop (A-loop); other site 862719017488 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 862719017489 TAP-like protein; Region: Abhydrolase_4; pfam08386 862719017490 LysR family transcriptional regulator; Provisional; Region: PRK14997 862719017491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719017492 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 862719017493 putative effector binding pocket; other site 862719017494 dimerization interface [polypeptide binding]; other site 862719017495 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 862719017496 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 862719017497 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 862719017498 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 862719017499 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 862719017500 putative dimer interface [polypeptide binding]; other site 862719017501 N-terminal domain interface [polypeptide binding]; other site 862719017502 putative substrate binding pocket (H-site) [chemical binding]; other site 862719017503 HAMP domain; Region: HAMP; pfam00672 862719017504 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 862719017505 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 862719017506 CcdB protein; Region: CcdB; cl03380 862719017507 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 862719017508 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 862719017509 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 862719017510 active site 862719017511 substrate binding site [chemical binding]; other site 862719017512 coenzyme B12 binding site [chemical binding]; other site 862719017513 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 862719017514 B12 binding site [chemical binding]; other site 862719017515 cobalt ligand [ion binding]; other site 862719017516 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 862719017517 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 862719017518 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 862719017519 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 862719017520 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 862719017521 carboxyltransferase (CT) interaction site; other site 862719017522 biotinylation site [posttranslational modification]; other site 862719017523 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 862719017524 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 862719017525 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 862719017526 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 862719017527 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 862719017528 non-specific DNA binding site [nucleotide binding]; other site 862719017529 salt bridge; other site 862719017530 sequence-specific DNA binding site [nucleotide binding]; other site 862719017531 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 862719017532 Domain of unknown function (DUF955); Region: DUF955; pfam06114 862719017533 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 862719017534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719017535 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719017536 substrate binding pocket [chemical binding]; other site 862719017537 membrane-bound complex binding site; other site 862719017538 hinge residues; other site 862719017539 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719017540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719017541 metal binding site [ion binding]; metal-binding site 862719017542 active site 862719017543 I-site; other site 862719017544 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719017545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719017546 active site 862719017547 phosphorylation site [posttranslational modification] 862719017548 intermolecular recognition site; other site 862719017549 dimerization interface [polypeptide binding]; other site 862719017550 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 862719017551 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 862719017552 cytochrome b; Provisional; Region: CYTB; MTH00191 862719017553 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 862719017554 interchain domain interface [polypeptide binding]; other site 862719017555 intrachain domain interface; other site 862719017556 heme bH binding site [chemical binding]; other site 862719017557 Qi binding site; other site 862719017558 heme bL binding site [chemical binding]; other site 862719017559 Qo binding site; other site 862719017560 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 862719017561 interchain domain interface [polypeptide binding]; other site 862719017562 intrachain domain interface; other site 862719017563 Qi binding site; other site 862719017564 Qo binding site; other site 862719017565 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 862719017566 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 862719017567 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 862719017568 [2Fe-2S] cluster binding site [ion binding]; other site 862719017569 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 862719017570 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 862719017571 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 862719017572 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 862719017573 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 862719017574 active site 862719017575 DNA binding site [nucleotide binding] 862719017576 Int/Topo IB signature motif; other site 862719017577 catalytic residues [active] 862719017578 MarC family integral membrane protein; Region: MarC; pfam01914 862719017579 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 862719017580 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 862719017581 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 862719017582 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 862719017583 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719017584 catalytic loop [active] 862719017585 iron binding site [ion binding]; other site 862719017586 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 862719017587 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 862719017588 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 862719017589 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 862719017590 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719017591 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 862719017592 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 862719017593 XdhC Rossmann domain; Region: XdhC_C; pfam13478 862719017594 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 862719017595 core domain interface [polypeptide binding]; other site 862719017596 delta subunit interface [polypeptide binding]; other site 862719017597 epsilon subunit interface [polypeptide binding]; other site 862719017598 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 862719017599 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 862719017600 Walker A motif; other site 862719017601 ATP binding site [chemical binding]; other site 862719017602 Walker B motif; other site 862719017603 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862719017604 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 862719017605 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 862719017606 ATP synthase A chain; Region: ATP-synt_A; cl00413 862719017607 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 862719017608 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 862719017609 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 862719017610 LBP interface [polypeptide binding]; other site 862719017611 epsilon subunit interface [polypeptide binding]; other site 862719017612 gamma subunit interface [polypeptide binding]; other site 862719017613 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 862719017614 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 862719017615 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 862719017616 alpha subunit interaction interface [polypeptide binding]; other site 862719017617 Walker A motif; other site 862719017618 ATP binding site [chemical binding]; other site 862719017619 Walker B motif; other site 862719017620 inhibitor binding site; inhibition site 862719017621 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 862719017622 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719017623 ligand binding site [chemical binding]; other site 862719017624 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 862719017625 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 862719017626 aldehyde dehydrogenase family 7 member; Region: PLN02315 862719017627 tetrameric interface [polypeptide binding]; other site 862719017628 NAD binding site [chemical binding]; other site 862719017629 catalytic residues [active] 862719017630 thiamine pyrophosphate protein; Validated; Region: PRK08199 862719017631 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 862719017632 PYR/PP interface [polypeptide binding]; other site 862719017633 dimer interface [polypeptide binding]; other site 862719017634 TPP binding site [chemical binding]; other site 862719017635 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 862719017636 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 862719017637 TPP-binding site [chemical binding]; other site 862719017638 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 862719017639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719017640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719017641 dimerization interface [polypeptide binding]; other site 862719017642 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 862719017643 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719017644 active site 862719017645 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 862719017646 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 862719017647 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 862719017648 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719017649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719017650 DNA binding residues [nucleotide binding] 862719017651 dimerization interface [polypeptide binding]; other site 862719017652 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719017653 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719017654 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719017655 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719017656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719017657 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719017658 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 862719017659 active site 862719017660 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 862719017661 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719017662 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 862719017663 putative ADP-binding pocket [chemical binding]; other site 862719017664 Chain length determinant protein; Region: Wzz; pfam02706 862719017665 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 862719017666 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719017667 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719017668 Methyltransferase domain; Region: Methyltransf_31; pfam13847 862719017669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719017670 S-adenosylmethionine binding site [chemical binding]; other site 862719017671 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 862719017672 Transcriptional regulators [Transcription]; Region: PurR; COG1609 862719017673 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719017674 DNA binding site [nucleotide binding] 862719017675 domain linker motif; other site 862719017676 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 862719017677 putative dimerization interface [polypeptide binding]; other site 862719017678 putative ligand binding site [chemical binding]; other site 862719017679 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 862719017680 active site 862719017681 phosphorylation site [posttranslational modification] 862719017682 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 862719017683 dimerization domain swap beta strand [polypeptide binding]; other site 862719017684 regulatory protein interface [polypeptide binding]; other site 862719017685 active site 862719017686 regulatory phosphorylation site [posttranslational modification]; other site 862719017687 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 862719017688 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 862719017689 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 862719017690 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 862719017691 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 862719017692 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 862719017693 putative substrate binding site [chemical binding]; other site 862719017694 putative ATP binding site [chemical binding]; other site 862719017695 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 862719017696 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 862719017697 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 862719017698 active site 862719017699 P-loop; other site 862719017700 phosphorylation site [posttranslational modification] 862719017701 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 862719017702 acetoin reductase; Validated; Region: PRK08643 862719017703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719017704 binding surface 862719017705 TPR motif; other site 862719017706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719017707 binding surface 862719017708 TPR motif; other site 862719017709 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 862719017710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719017711 TPR motif; other site 862719017712 binding surface 862719017713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719017714 binding surface 862719017715 TPR motif; other site 862719017716 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 862719017717 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 862719017718 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 862719017719 DNA binding residues [nucleotide binding] 862719017720 Flagellar protein FliS; Region: FliS; cl00654 862719017721 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 862719017722 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 862719017723 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 862719017724 flagellin; Provisional; Region: PRK12802 862719017725 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719017726 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862719017727 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 862719017728 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719017729 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862719017730 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 862719017731 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862719017732 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 862719017733 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 862719017734 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862719017735 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 862719017736 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 862719017737 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 862719017738 substrate binding site [chemical binding]; other site 862719017739 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 862719017740 oxyanion hole (OAH) forming residues; other site 862719017741 trimer interface [polypeptide binding]; other site 862719017742 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 862719017743 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719017744 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719017745 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 862719017746 Cytochrome c; Region: Cytochrom_C; cl11414 862719017747 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 862719017748 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 862719017749 alpha subunit interface [polypeptide binding]; other site 862719017750 TPP binding site [chemical binding]; other site 862719017751 heterodimer interface [polypeptide binding]; other site 862719017752 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 862719017753 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 862719017754 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 862719017755 tetramer interface [polypeptide binding]; other site 862719017756 TPP-binding site [chemical binding]; other site 862719017757 heterodimer interface [polypeptide binding]; other site 862719017758 phosphorylation loop region [posttranslational modification] 862719017759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719017760 putative PBP binding loops; other site 862719017761 ABC-ATPase subunit interface; other site 862719017762 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 862719017763 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 862719017764 Walker A/P-loop; other site 862719017765 ATP binding site [chemical binding]; other site 862719017766 Q-loop/lid; other site 862719017767 ABC transporter signature motif; other site 862719017768 Walker B; other site 862719017769 D-loop; other site 862719017770 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 862719017771 H-loop/switch region; other site 862719017772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719017773 dimer interface [polypeptide binding]; other site 862719017774 conserved gate region; other site 862719017775 ABC-ATPase subunit interface; other site 862719017776 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 862719017777 Isochorismatase family; Region: Isochorismatase; pfam00857 862719017778 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 862719017779 catalytic triad [active] 862719017780 conserved cis-peptide bond; other site 862719017781 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 862719017782 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 862719017783 AsnC family; Region: AsnC_trans_reg; pfam01037 862719017784 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 862719017785 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719017786 FeS/SAM binding site; other site 862719017787 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 862719017788 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 862719017789 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 862719017790 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 862719017791 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 862719017792 PqqA family; Region: PqqA; cl15372 862719017793 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 862719017794 active site residue [active] 862719017795 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719017796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719017797 active site 862719017798 phosphorylation site [posttranslational modification] 862719017799 intermolecular recognition site; other site 862719017800 dimerization interface [polypeptide binding]; other site 862719017801 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719017802 DNA binding residues [nucleotide binding] 862719017803 dimerization interface [polypeptide binding]; other site 862719017804 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 862719017805 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 862719017806 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862719017807 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 862719017808 putative active site [active] 862719017809 phosphogluconate dehydratase; Validated; Region: PRK09054 862719017810 6-phosphogluconate dehydratase; Region: edd; TIGR01196 862719017811 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 862719017812 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 862719017813 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 862719017814 potential protein location (conserved protein of unknown function [Azospirillum lipoferum 4B]) that overlaps RNA (ribosomal RNA 23S ribosomal RNA) 862719017815 potential protein location (protein of unknown function [Azospirillum lipoferum 4B]) that overlaps RNA (ribosomal RNA 23S ribosomal RNA) 862719017816 potential protein location (protein of unknown function [Azospirillum lipoferum 4B]) that overlaps RNA (ribosomal RNA 5S ribosomal RNA) 862719017817 Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560 862719017818 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 862719017819 putative active site [active] 862719017820 catalytic site [active] 862719017821 putative metal binding site [ion binding]; other site 862719017822 Rod binding protein; Region: Rod-binding; pfam10135 862719017823 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 862719017824 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 862719017825 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 862719017826 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719017827 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862719017828 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 862719017829 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 862719017830 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 862719017831 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 862719017832 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719017833 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862719017834 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 862719017835 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719017836 ligand binding site [chemical binding]; other site 862719017837 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 862719017838 flagellar motor protein MotA; Validated; Region: PRK09110 862719017839 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 862719017840 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 862719017841 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 862719017842 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862719017843 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 862719017844 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 862719017845 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 862719017846 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 862719017847 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 862719017848 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 862719017849 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 862719017850 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 862719017851 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 862719017852 Uncharacterized conserved protein [Function unknown]; Region: COG3334 862719017853 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 862719017854 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 862719017855 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 862719017856 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 862719017857 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 862719017858 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 862719017859 flagellar assembly protein H; Validated; Region: fliH; PRK06032 862719017860 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 862719017861 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 862719017862 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 862719017863 MgtE intracellular N domain; Region: MgtE_N; cl15244 862719017864 FliG C-terminal domain; Region: FliG_C; pfam01706 862719017865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 862719017866 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 862719017867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719017868 DNA binding site [nucleotide binding] 862719017869 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 862719017870 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 862719017871 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 862719017872 Flagellar protein FlaF; Region: FlaF; pfam07309 862719017873 Flagellar protein FlbT; Region: FlbT; pfam07378 862719017874 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 862719017875 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 862719017876 Protein of unknown function (DUF454); Region: DUF454; cl01063 862719017877 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 862719017878 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 862719017879 Walker A motif/ATP binding site; other site 862719017880 Walker B motif; other site 862719017881 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 862719017882 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 862719017883 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 862719017884 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 862719017885 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 862719017886 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 862719017887 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862719017888 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719017889 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 862719017890 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719017891 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 862719017892 FHIPEP family; Region: FHIPEP; pfam00771 862719017893 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 862719017894 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 862719017895 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 862719017896 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 862719017897 dihydropteroate synthase; Region: DHPS; TIGR01496 862719017898 substrate binding pocket [chemical binding]; other site 862719017899 dimer interface [polypeptide binding]; other site 862719017900 inhibitor binding site; inhibition site 862719017901 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 862719017902 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 862719017903 active site 862719017904 substrate binding site [chemical binding]; other site 862719017905 metal binding site [ion binding]; metal-binding site 862719017906 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 862719017907 dimer interface [polypeptide binding]; other site 862719017908 substrate binding site [chemical binding]; other site 862719017909 ATP binding site [chemical binding]; other site 862719017910 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 862719017911 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 862719017912 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719017913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 862719017914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719017915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 862719017916 dimerization interface [polypeptide binding]; other site 862719017917 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 862719017918 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 862719017919 catalytic loop [active] 862719017920 iron binding site [ion binding]; other site 862719017921 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 862719017922 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 862719017923 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 862719017924 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719017925 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 862719017926 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719017927 catalytic core [active] 862719017928 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 862719017929 active site 862719017930 SUMO-1 interface [polypeptide binding]; other site 862719017931 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 862719017932 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 862719017933 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 862719017934 PRC-barrel domain; Region: PRC; pfam05239 862719017935 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 862719017936 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 862719017937 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 862719017938 TrkA-N domain; Region: TrkA_N; pfam02254 862719017939 TrkA-C domain; Region: TrkA_C; pfam02080 862719017940 TrkA-N domain; Region: TrkA_N; pfam02254 862719017941 TrkA-C domain; Region: TrkA_C; pfam02080 862719017942 putative glutathione S-transferase; Provisional; Region: PRK10357 862719017943 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 862719017944 putative C-terminal domain interface [polypeptide binding]; other site 862719017945 putative GSH binding site (G-site) [chemical binding]; other site 862719017946 putative dimer interface [polypeptide binding]; other site 862719017947 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 862719017948 dimer interface [polypeptide binding]; other site 862719017949 N-terminal domain interface [polypeptide binding]; other site 862719017950 putative substrate binding pocket (H-site) [chemical binding]; other site 862719017951 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 862719017952 dimerization interface [polypeptide binding]; other site 862719017953 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719017954 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719017955 putative CheW interface [polypeptide binding]; other site 862719017956 PBP superfamily domain; Region: PBP_like_2; cl17296 862719017957 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 862719017958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719017959 dimer interface [polypeptide binding]; other site 862719017960 conserved gate region; other site 862719017961 putative PBP binding loops; other site 862719017962 ABC-ATPase subunit interface; other site 862719017963 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 862719017964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719017965 dimer interface [polypeptide binding]; other site 862719017966 conserved gate region; other site 862719017967 putative PBP binding loops; other site 862719017968 ABC-ATPase subunit interface; other site 862719017969 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 862719017970 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 862719017971 Walker A/P-loop; other site 862719017972 ATP binding site [chemical binding]; other site 862719017973 Q-loop/lid; other site 862719017974 ABC transporter signature motif; other site 862719017975 Walker B; other site 862719017976 D-loop; other site 862719017977 H-loop/switch region; other site 862719017978 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719017979 Winged helix-turn helix; Region: HTH_29; pfam13551 862719017980 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719017981 Homeodomain-like domain; Region: HTH_32; pfam13565 862719017982 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 862719017983 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 862719017984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719017985 Major Facilitator Superfamily; Region: MFS_1; pfam07690 862719017986 putative substrate translocation pore; other site 862719017987 hypothetical protein; Provisional; Region: PRK01254 862719017988 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 862719017989 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 862719017990 Response regulator receiver domain; Region: Response_reg; pfam00072 862719017991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719017992 active site 862719017993 phosphorylation site [posttranslational modification] 862719017994 intermolecular recognition site; other site 862719017995 dimerization interface [polypeptide binding]; other site 862719017996 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862719017997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719017998 PAS domain; Region: PAS_9; pfam13426 862719017999 putative active site [active] 862719018000 heme pocket [chemical binding]; other site 862719018001 PAS fold; Region: PAS_4; pfam08448 862719018002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 862719018003 Histidine kinase; Region: HisKA_2; pfam07568 862719018004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719018005 ATP binding site [chemical binding]; other site 862719018006 Mg2+ binding site [ion binding]; other site 862719018007 G-X-G motif; other site 862719018008 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 862719018009 CheC-like family; Region: CheC; pfam04509 862719018010 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 862719018011 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 862719018012 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 862719018013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018014 active site 862719018015 phosphorylation site [posttranslational modification] 862719018016 intermolecular recognition site; other site 862719018017 dimerization interface [polypeptide binding]; other site 862719018018 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 862719018019 Zn2+ binding site [ion binding]; other site 862719018020 Mg2+ binding site [ion binding]; other site 862719018021 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862719018022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719018023 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862719018024 putative active site [active] 862719018025 heme pocket [chemical binding]; other site 862719018026 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719018027 putative active site [active] 862719018028 heme pocket [chemical binding]; other site 862719018029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719018030 PAS fold; Region: PAS_3; pfam08447 862719018031 putative active site [active] 862719018032 heme pocket [chemical binding]; other site 862719018033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719018034 dimer interface [polypeptide binding]; other site 862719018035 phosphorylation site [posttranslational modification] 862719018036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719018037 ATP binding site [chemical binding]; other site 862719018038 Mg2+ binding site [ion binding]; other site 862719018039 G-X-G motif; other site 862719018040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018041 active site 862719018042 phosphorylation site [posttranslational modification] 862719018043 intermolecular recognition site; other site 862719018044 dimerization interface [polypeptide binding]; other site 862719018045 Response regulator receiver domain; Region: Response_reg; pfam00072 862719018046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018047 active site 862719018048 phosphorylation site [posttranslational modification] 862719018049 intermolecular recognition site; other site 862719018050 dimerization interface [polypeptide binding]; other site 862719018051 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 862719018052 putative binding surface; other site 862719018053 active site 862719018054 Uncharacterized conserved protein [Function unknown]; Region: COG3287 862719018055 FIST N domain; Region: FIST; pfam08495 862719018056 FIST C domain; Region: FIST_C; pfam10442 862719018057 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719018058 dimerization interface [polypeptide binding]; other site 862719018059 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719018060 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719018061 dimer interface [polypeptide binding]; other site 862719018062 putative CheW interface [polypeptide binding]; other site 862719018063 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 862719018064 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 862719018065 Transcriptional regulators [Transcription]; Region: GntR; COG1802 862719018066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719018067 DNA-binding site [nucleotide binding]; DNA binding site 862719018068 FCD domain; Region: FCD; pfam07729 862719018069 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 862719018070 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 862719018071 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 862719018072 putative oxidoreductase; Provisional; Region: PRK10083 862719018073 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 862719018074 putative NAD(P) binding site [chemical binding]; other site 862719018075 catalytic Zn binding site [ion binding]; other site 862719018076 structural Zn binding site [ion binding]; other site 862719018077 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 862719018078 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 862719018079 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 862719018080 DctM-like transporters; Region: DctM; pfam06808 862719018081 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 862719018082 mannonate dehydratase; Provisional; Region: PRK03906 862719018083 mannonate dehydratase; Region: uxuA; TIGR00695 862719018084 PAS fold; Region: PAS_4; pfam08448 862719018085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719018086 putative active site [active] 862719018087 heme pocket [chemical binding]; other site 862719018088 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719018089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719018090 Walker A motif; other site 862719018091 ATP binding site [chemical binding]; other site 862719018092 Walker B motif; other site 862719018093 arginine finger; other site 862719018094 PAS fold; Region: PAS_4; pfam08448 862719018095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719018096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719018097 dimer interface [polypeptide binding]; other site 862719018098 phosphorylation site [posttranslational modification] 862719018099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719018100 ATP binding site [chemical binding]; other site 862719018101 Mg2+ binding site [ion binding]; other site 862719018102 G-X-G motif; other site 862719018103 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 862719018104 DctM-like transporters; Region: DctM; pfam06808 862719018105 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 862719018106 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17449609, 17540897; Product type e : enzyme 862719018107 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 862719018108 multiple promoter invertase; Provisional; Region: mpi; PRK13413 862719018109 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 862719018110 catalytic residues [active] 862719018111 catalytic nucleophile [active] 862719018112 Presynaptic Site I dimer interface [polypeptide binding]; other site 862719018113 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 862719018114 Synaptic Flat tetramer interface [polypeptide binding]; other site 862719018115 Synaptic Site I dimer interface [polypeptide binding]; other site 862719018116 DNA binding site [nucleotide binding] 862719018117 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 862719018118 DNA-binding interface [nucleotide binding]; DNA binding site 862719018119 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 862719018120 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 862719018121 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 862719018122 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 862719018123 Winged helix-turn helix; Region: HTH_29; pfam13551 862719018124 Helix-turn-helix domain; Region: HTH_28; pfam13518 862719018125 Winged helix-turn helix; Region: HTH_33; pfam13592 862719018126 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16640791; Product type pe : putative enzyme 862719018127 Evidence 2b : Function of strongly homologous gene; PubMedId : 15917576, 16785225, 9420034; Product type e : enzyme 862719018128 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 862719018129 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 862719018130 Walker A/P-loop; other site 862719018131 ATP binding site [chemical binding]; other site 862719018132 Q-loop/lid; other site 862719018133 ABC transporter signature motif; other site 862719018134 Walker B; other site 862719018135 D-loop; other site 862719018136 H-loop/switch region; other site 862719018137 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 862719018138 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 862719018139 ABC-ATPase subunit interface; other site 862719018140 dimer interface [polypeptide binding]; other site 862719018141 putative PBP binding regions; other site 862719018142 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 862719018143 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 862719018144 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 862719018145 FAD binding pocket [chemical binding]; other site 862719018146 FAD binding motif [chemical binding]; other site 862719018147 phosphate binding motif [ion binding]; other site 862719018148 NAD binding pocket [chemical binding]; other site 862719018149 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 862719018150 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 862719018151 intersubunit interface [polypeptide binding]; other site 862719018152 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 862719018153 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 862719018154 N-terminal plug; other site 862719018155 ligand-binding site [chemical binding]; other site 862719018156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719018157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719018158 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 862719018159 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 862719018160 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2159625, 2824781; Product type e : enzyme 862719018161 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 862719018162 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 862719018163 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 862719018164 GAF domain; Region: GAF; pfam01590 862719018165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719018166 Walker B motif; other site 862719018167 arginine finger; other site 862719018168 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719018169 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 862719018170 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 862719018171 heme-binding site [chemical binding]; other site 862719018172 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 862719018173 FAD binding pocket [chemical binding]; other site 862719018174 FAD binding motif [chemical binding]; other site 862719018175 phosphate binding motif [ion binding]; other site 862719018176 beta-alpha-beta structure motif; other site 862719018177 NAD binding pocket [chemical binding]; other site 862719018178 Heme binding pocket [chemical binding]; other site 862719018179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719018180 dimerization interface [polypeptide binding]; other site 862719018181 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719018182 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719018183 dimer interface [polypeptide binding]; other site 862719018184 putative CheW interface [polypeptide binding]; other site 862719018185 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 862719018186 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 862719018187 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 862719018188 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 862719018189 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 862719018190 putative active site [active] 862719018191 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 862719018192 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 862719018193 active site 862719018194 intersubunit interface [polypeptide binding]; other site 862719018195 catalytic residue [active] 862719018196 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 862719018197 Tripeptidyl peptidase II; Region: TPPII; pfam12580 862719018198 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719018199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018200 active site 862719018201 phosphorylation site [posttranslational modification] 862719018202 intermolecular recognition site; other site 862719018203 dimerization interface [polypeptide binding]; other site 862719018204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719018205 DNA binding residues [nucleotide binding] 862719018206 dimerization interface [polypeptide binding]; other site 862719018207 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 862719018208 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 862719018209 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 862719018210 ligand binding site [chemical binding]; other site 862719018211 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 862719018212 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 862719018213 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 862719018214 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 862719018215 dimerization interface [polypeptide binding]; other site 862719018216 ligand binding site [chemical binding]; other site 862719018217 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 862719018218 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 862719018219 Walker A/P-loop; other site 862719018220 ATP binding site [chemical binding]; other site 862719018221 Q-loop/lid; other site 862719018222 ABC transporter signature motif; other site 862719018223 Walker B; other site 862719018224 D-loop; other site 862719018225 H-loop/switch region; other site 862719018226 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 862719018227 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 862719018228 Walker A/P-loop; other site 862719018229 ATP binding site [chemical binding]; other site 862719018230 Q-loop/lid; other site 862719018231 ABC transporter signature motif; other site 862719018232 Walker B; other site 862719018233 D-loop; other site 862719018234 H-loop/switch region; other site 862719018235 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719018236 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 862719018237 TM-ABC transporter signature motif; other site 862719018238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719018239 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 862719018240 TM-ABC transporter signature motif; other site 862719018241 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 862719018242 fructokinase; Reviewed; Region: PRK09557 862719018243 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 862719018244 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 862719018245 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 862719018246 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 862719018247 Ligand binding site; other site 862719018248 Putative Catalytic site; other site 862719018249 DXD motif; other site 862719018250 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 862719018251 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 862719018252 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719018253 protein binding site [polypeptide binding]; other site 862719018254 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 862719018255 protein binding site [polypeptide binding]; other site 862719018256 PAS fold; Region: PAS_7; pfam12860 862719018257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719018258 PAS fold; Region: PAS_3; pfam08447 862719018259 putative active site [active] 862719018260 heme pocket [chemical binding]; other site 862719018261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719018262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719018263 dimer interface [polypeptide binding]; other site 862719018264 phosphorylation site [posttranslational modification] 862719018265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719018266 ATP binding site [chemical binding]; other site 862719018267 Mg2+ binding site [ion binding]; other site 862719018268 G-X-G motif; other site 862719018269 Predicted membrane protein [Function unknown]; Region: COG1238 862719018270 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 862719018271 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862719018272 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 862719018273 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 862719018274 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 862719018275 active site 862719018276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719018277 S-adenosylmethionine binding site [chemical binding]; other site 862719018278 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 862719018279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719018280 dimerization interface [polypeptide binding]; other site 862719018281 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719018282 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719018283 dimer interface [polypeptide binding]; other site 862719018284 putative CheW interface [polypeptide binding]; other site 862719018285 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 862719018286 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 862719018287 DNA binding residues [nucleotide binding] 862719018288 putative dimer interface [polypeptide binding]; other site 862719018289 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 862719018290 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 862719018291 dimer interface [polypeptide binding]; other site 862719018292 acyl-activating enzyme (AAE) consensus motif; other site 862719018293 putative active site [active] 862719018294 AMP binding site [chemical binding]; other site 862719018295 putative CoA binding site [chemical binding]; other site 862719018296 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 862719018297 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 862719018298 N- and C-terminal domain interface [polypeptide binding]; other site 862719018299 active site 862719018300 MgATP binding site [chemical binding]; other site 862719018301 catalytic site [active] 862719018302 metal binding site [ion binding]; metal-binding site 862719018303 glycerol binding site [chemical binding]; other site 862719018304 homotetramer interface [polypeptide binding]; other site 862719018305 homodimer interface [polypeptide binding]; other site 862719018306 FBP binding site [chemical binding]; other site 862719018307 protein IIAGlc interface [polypeptide binding]; other site 862719018308 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 862719018309 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 862719018310 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 862719018311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719018312 dimer interface [polypeptide binding]; other site 862719018313 conserved gate region; other site 862719018314 putative PBP binding loops; other site 862719018315 ABC-ATPase subunit interface; other site 862719018316 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 862719018317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719018318 putative PBP binding loops; other site 862719018319 dimer interface [polypeptide binding]; other site 862719018320 ABC-ATPase subunit interface; other site 862719018321 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 862719018322 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 862719018323 Walker A/P-loop; other site 862719018324 ATP binding site [chemical binding]; other site 862719018325 Q-loop/lid; other site 862719018326 ABC transporter signature motif; other site 862719018327 Walker B; other site 862719018328 D-loop; other site 862719018329 H-loop/switch region; other site 862719018330 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 862719018331 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 862719018332 Walker A/P-loop; other site 862719018333 ATP binding site [chemical binding]; other site 862719018334 Q-loop/lid; other site 862719018335 ABC transporter signature motif; other site 862719018336 Walker B; other site 862719018337 D-loop; other site 862719018338 H-loop/switch region; other site 862719018339 TOBE domain; Region: TOBE_2; pfam08402 862719018340 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 862719018341 HAMP domain; Region: HAMP; pfam00672 862719018342 dimerization interface [polypeptide binding]; other site 862719018343 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719018344 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719018345 dimer interface [polypeptide binding]; other site 862719018346 putative CheW interface [polypeptide binding]; other site 862719018347 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 862719018348 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 862719018349 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 862719018350 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 862719018351 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 862719018352 active site 862719018353 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 862719018354 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 862719018355 GIY-YIG motif/motif A; other site 862719018356 active site 862719018357 catalytic site [active] 862719018358 putative DNA binding site [nucleotide binding]; other site 862719018359 metal binding site [ion binding]; metal-binding site 862719018360 UvrB/uvrC motif; Region: UVR; pfam02151 862719018361 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 862719018362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719018363 dimerization interface [polypeptide binding]; other site 862719018364 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719018365 dimer interface [polypeptide binding]; other site 862719018366 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719018367 putative CheW interface [polypeptide binding]; other site 862719018368 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 862719018369 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 862719018370 Universal stress protein family; Region: Usp; pfam00582 862719018371 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719018372 Ligand Binding Site [chemical binding]; other site 862719018373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 862719018374 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 862719018375 Predicted kinase [General function prediction only]; Region: COG0645 862719018376 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 862719018377 Flagellar protein FlaF; Region: FlaF; cl11454 862719018378 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 862719018379 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 862719018380 EamA-like transporter family; Region: EamA; pfam00892 862719018381 EamA-like transporter family; Region: EamA; cl17759 862719018382 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 862719018383 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 862719018384 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 862719018385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 862719018386 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 862719018387 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719018388 dimer interface [polypeptide binding]; other site 862719018389 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 862719018390 putative CheW interface [polypeptide binding]; other site 862719018391 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 862719018392 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 862719018393 DsrE/DsrF-like family; Region: DrsE; cl00672 862719018394 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 862719018395 NMT1-like family; Region: NMT1_2; pfam13379 862719018396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719018397 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 862719018398 putative substrate translocation pore; other site 862719018399 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 862719018400 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 862719018401 ligand binding site [chemical binding]; other site 862719018402 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719018403 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719018404 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 862719018405 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719018406 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 862719018407 methionine sulfoxide reductase B; Provisional; Region: PRK00222 862719018408 SelR domain; Region: SelR; pfam01641 862719018409 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 862719018410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018411 active site 862719018412 phosphorylation site [posttranslational modification] 862719018413 intermolecular recognition site; other site 862719018414 dimerization interface [polypeptide binding]; other site 862719018415 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 862719018416 DNA binding site [nucleotide binding] 862719018417 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 862719018418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719018419 DNA-binding site [nucleotide binding]; DNA binding site 862719018420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 862719018421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 862719018422 homodimer interface [polypeptide binding]; other site 862719018423 catalytic residue [active] 862719018424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719018425 PAS domain; Region: PAS_9; pfam13426 862719018426 putative active site [active] 862719018427 heme pocket [chemical binding]; other site 862719018428 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719018429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719018430 dimer interface [polypeptide binding]; other site 862719018431 phosphorylation site [posttranslational modification] 862719018432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719018433 ATP binding site [chemical binding]; other site 862719018434 Mg2+ binding site [ion binding]; other site 862719018435 G-X-G motif; other site 862719018436 Response regulator receiver domain; Region: Response_reg; pfam00072 862719018437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018438 active site 862719018439 phosphorylation site [posttranslational modification] 862719018440 intermolecular recognition site; other site 862719018441 dimerization interface [polypeptide binding]; other site 862719018442 Hpt domain; Region: Hpt; pfam01627 862719018443 putative binding surface; other site 862719018444 active site 862719018445 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 862719018446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719018447 substrate binding pocket [chemical binding]; other site 862719018448 membrane-bound complex binding site; other site 862719018449 hinge residues; other site 862719018450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719018451 putative substrate translocation pore; other site 862719018452 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 862719018453 Na binding site [ion binding]; other site 862719018454 PAS fold; Region: PAS_7; pfam12860 862719018455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719018456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719018457 dimer interface [polypeptide binding]; other site 862719018458 phosphorylation site [posttranslational modification] 862719018459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719018460 ATP binding site [chemical binding]; other site 862719018461 Mg2+ binding site [ion binding]; other site 862719018462 G-X-G motif; other site 862719018463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018464 active site 862719018465 phosphorylation site [posttranslational modification] 862719018466 intermolecular recognition site; other site 862719018467 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 862719018468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018469 active site 862719018470 phosphorylation site [posttranslational modification] 862719018471 intermolecular recognition site; other site 862719018472 dimerization interface [polypeptide binding]; other site 862719018473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 862719018474 DNA binding residues [nucleotide binding] 862719018475 dimerization interface [polypeptide binding]; other site 862719018476 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 862719018477 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 862719018478 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 862719018479 dimer interface [polypeptide binding]; other site 862719018480 active site 862719018481 citrylCoA binding site [chemical binding]; other site 862719018482 NADH binding [chemical binding]; other site 862719018483 cationic pore residues; other site 862719018484 oxalacetate/citrate binding site [chemical binding]; other site 862719018485 coenzyme A binding site [chemical binding]; other site 862719018486 catalytic triad [active] 862719018487 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862719018488 GAF domain; Region: GAF; pfam01590 862719018489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719018490 PAS fold; Region: PAS_3; pfam08447 862719018491 putative active site [active] 862719018492 heme pocket [chemical binding]; other site 862719018493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719018494 PAS fold; Region: PAS_3; pfam08447 862719018495 putative active site [active] 862719018496 heme pocket [chemical binding]; other site 862719018497 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 862719018498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719018499 dimer interface [polypeptide binding]; other site 862719018500 phosphorylation site [posttranslational modification] 862719018501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719018502 ATP binding site [chemical binding]; other site 862719018503 Mg2+ binding site [ion binding]; other site 862719018504 G-X-G motif; other site 862719018505 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 862719018506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018507 active site 862719018508 phosphorylation site [posttranslational modification] 862719018509 intermolecular recognition site; other site 862719018510 Response regulator receiver domain; Region: Response_reg; pfam00072 862719018511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018512 active site 862719018513 phosphorylation site [posttranslational modification] 862719018514 intermolecular recognition site; other site 862719018515 dimerization interface [polypeptide binding]; other site 862719018516 Hpt domain; Region: Hpt; pfam01627 862719018517 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 862719018518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018519 active site 862719018520 phosphorylation site [posttranslational modification] 862719018521 intermolecular recognition site; other site 862719018522 dimerization interface [polypeptide binding]; other site 862719018523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719018524 Walker A motif; other site 862719018525 ATP binding site [chemical binding]; other site 862719018526 Walker B motif; other site 862719018527 arginine finger; other site 862719018528 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719018529 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 862719018530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 862719018531 DNA-binding site [nucleotide binding]; DNA binding site 862719018532 FCD domain; Region: FCD; pfam07729 862719018533 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 862719018534 FAD binding domain; Region: FAD_binding_4; pfam01565 862719018535 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 862719018536 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 862719018537 Cysteine-rich domain; Region: CCG; pfam02754 862719018538 Cysteine-rich domain; Region: CCG; pfam02754 862719018539 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 862719018540 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 862719018541 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 862719018542 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 862719018543 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 862719018544 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 862719018545 hydroxyglutarate oxidase; Provisional; Region: PRK11728 862719018546 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 862719018547 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 862719018548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 862719018549 Walker A motif; other site 862719018550 ATP binding site [chemical binding]; other site 862719018551 Walker B motif; other site 862719018552 arginine finger; other site 862719018553 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 862719018554 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 862719018555 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 862719018556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 862719018557 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 862719018558 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 862719018559 Fe-S cluster binding site [ion binding]; other site 862719018560 active site 862719018561 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 862719018562 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 862719018563 N-acetyl-D-glucosamine binding site [chemical binding]; other site 862719018564 catalytic residue [active] 862719018565 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 862719018566 MPT binding site; other site 862719018567 trimer interface [polypeptide binding]; other site 862719018568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719018569 TPR motif; other site 862719018570 binding surface 862719018571 TPR repeat; Region: TPR_11; pfam13414 862719018572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719018573 TPR motif; other site 862719018574 binding surface 862719018575 TPR repeat; Region: TPR_11; pfam13414 862719018576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 862719018577 binding surface 862719018578 TPR motif; other site 862719018579 TPR repeat; Region: TPR_11; pfam13414 862719018580 Hemerythrin; Region: Hemerythrin; cd12107 862719018581 Fe binding site [ion binding]; other site 862719018582 Fic/DOC family; Region: Fic; pfam02661 862719018583 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 862719018584 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 862719018585 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 862719018586 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 862719018587 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 862719018588 active site 862719018589 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 862719018590 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 862719018591 Protein of unknown function, DUF482; Region: DUF482; pfam04339 862719018592 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 862719018593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719018594 putative active site [active] 862719018595 heme pocket [chemical binding]; other site 862719018596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719018597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719018598 dimer interface [polypeptide binding]; other site 862719018599 phosphorylation site [posttranslational modification] 862719018600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719018601 ATP binding site [chemical binding]; other site 862719018602 Mg2+ binding site [ion binding]; other site 862719018603 G-X-G motif; other site 862719018604 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 862719018605 Protein of unknown function (DUF330); Region: DUF330; cl01135 862719018606 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 862719018607 mce related protein; Region: MCE; pfam02470 862719018608 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 862719018609 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 862719018610 Walker A/P-loop; other site 862719018611 ATP binding site [chemical binding]; other site 862719018612 Q-loop/lid; other site 862719018613 ABC transporter signature motif; other site 862719018614 Walker B; other site 862719018615 D-loop; other site 862719018616 H-loop/switch region; other site 862719018617 STAS domain; Region: STAS_2; pfam13466 862719018618 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 862719018619 Permease; Region: Permease; pfam02405 862719018620 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719018621 active site 862719018622 Predicted membrane protein [Function unknown]; Region: COG2259 862719018623 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 862719018624 EamA-like transporter family; Region: EamA; pfam00892 862719018625 EamA-like transporter family; Region: EamA; pfam00892 862719018626 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 862719018627 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013 862719018628 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 862719018629 metal binding site [ion binding]; metal-binding site 862719018630 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 862719018631 GIY-YIG motif/motif A; other site 862719018632 putative active site [active] 862719018633 putative metal binding site [ion binding]; other site 862719018634 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 862719018635 CHASE domain; Region: CHASE; pfam03924 862719018636 PAS domain S-box; Region: sensory_box; TIGR00229 862719018637 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719018638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719018639 metal binding site [ion binding]; metal-binding site 862719018640 active site 862719018641 I-site; other site 862719018642 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 862719018643 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 862719018644 heme-binding site [chemical binding]; other site 862719018645 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719018646 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719018647 dimer interface [polypeptide binding]; other site 862719018648 putative CheW interface [polypeptide binding]; other site 862719018649 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 862719018650 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 862719018651 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 862719018652 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 862719018653 active site 862719018654 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 862719018655 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 862719018656 replicative DNA helicase; Provisional; Region: PRK09165 862719018657 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 862719018658 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 862719018659 Walker A motif; other site 862719018660 ATP binding site [chemical binding]; other site 862719018661 Walker B motif; other site 862719018662 DNA binding loops [nucleotide binding] 862719018663 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 862719018664 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 862719018665 active site 862719018666 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 862719018667 dimer interface [polypeptide binding]; other site 862719018668 substrate binding site [chemical binding]; other site 862719018669 catalytic residues [active] 862719018670 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 862719018671 Permease; Region: Permease; pfam02405 862719018672 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 862719018673 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 862719018674 Walker A/P-loop; other site 862719018675 ATP binding site [chemical binding]; other site 862719018676 Q-loop/lid; other site 862719018677 ABC transporter signature motif; other site 862719018678 Walker B; other site 862719018679 D-loop; other site 862719018680 H-loop/switch region; other site 862719018681 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 862719018682 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 862719018683 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 862719018684 beta-galactosidase; Region: BGL; TIGR03356 862719018685 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 862719018686 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 862719018687 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 862719018688 Electron transfer flavoprotein domain; Region: ETF; pfam01012 862719018689 Ligand binding site [chemical binding]; other site 862719018690 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 862719018691 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 862719018692 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 862719018693 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 862719018694 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 862719018695 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 862719018696 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 862719018697 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 862719018698 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 862719018699 Trp docking motif [polypeptide binding]; other site 862719018700 putative active site [active] 862719018701 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 862719018702 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 862719018703 allantoate amidohydrolase; Reviewed; Region: PRK09290 862719018704 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 862719018705 active site 862719018706 metal binding site [ion binding]; metal-binding site 862719018707 dimer interface [polypeptide binding]; other site 862719018708 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 862719018709 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 862719018710 putative metal binding site [ion binding]; other site 862719018711 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 862719018712 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 862719018713 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 862719018714 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 862719018715 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 862719018716 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 862719018717 dimer interface [polypeptide binding]; other site 862719018718 motif 1; other site 862719018719 active site 862719018720 motif 2; other site 862719018721 motif 3; other site 862719018722 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719018723 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 862719018724 active site 862719018725 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 862719018726 active site 862719018727 acyl carrier protein; Provisional; Region: PRK07081 862719018728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 862719018729 dimerization interface [polypeptide binding]; other site 862719018730 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 862719018731 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 862719018732 dimer interface [polypeptide binding]; other site 862719018733 putative CheW interface [polypeptide binding]; other site 862719018734 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 862719018735 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 862719018736 ligand binding site [chemical binding]; other site 862719018737 flexible hinge region; other site 862719018738 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 862719018739 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 862719018740 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 862719018741 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 862719018742 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 862719018743 beta-galactosidase; Region: BGL; TIGR03356 862719018744 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 862719018745 alpha-galactosidase; Provisional; Region: PRK15076 862719018746 NAD(P) binding site [chemical binding]; other site 862719018747 LDH/MDH dimer interface [polypeptide binding]; other site 862719018748 substrate binding site [chemical binding]; other site 862719018749 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 862719018750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719018751 putative substrate translocation pore; other site 862719018752 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 862719018753 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 862719018754 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 862719018755 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 862719018756 Glutamate binding site [chemical binding]; other site 862719018757 NAD binding site [chemical binding]; other site 862719018758 catalytic residues [active] 862719018759 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 862719018760 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 862719018761 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 862719018762 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 862719018763 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 862719018764 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 862719018765 NAD binding site [chemical binding]; other site 862719018766 catalytic Zn binding site [ion binding]; other site 862719018767 structural Zn binding site [ion binding]; other site 862719018768 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 862719018769 active site 862719018770 catalytic triad [active] 862719018771 dimer interface [polypeptide binding]; other site 862719018772 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 862719018773 Mechanosensitive ion channel; Region: MS_channel; pfam00924 862719018774 metabolite-proton symporter; Region: 2A0106; TIGR00883 862719018775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719018776 putative substrate translocation pore; other site 862719018777 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 862719018778 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 862719018779 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 862719018780 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 862719018781 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 862719018782 D-pathway; other site 862719018783 Putative ubiquinol binding site [chemical binding]; other site 862719018784 Low-spin heme (heme b) binding site [chemical binding]; other site 862719018785 Putative water exit pathway; other site 862719018786 Binuclear center (heme o3/CuB) [ion binding]; other site 862719018787 K-pathway; other site 862719018788 Putative proton exit pathway; other site 862719018789 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 862719018790 Subunit I/III interface [polypeptide binding]; other site 862719018791 Subunit III/IV interface [polypeptide binding]; other site 862719018792 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 862719018793 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 862719018794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719018795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719018796 dimer interface [polypeptide binding]; other site 862719018797 phosphorylation site [posttranslational modification] 862719018798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719018799 ATP binding site [chemical binding]; other site 862719018800 Mg2+ binding site [ion binding]; other site 862719018801 G-X-G motif; other site 862719018802 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 862719018803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719018804 active site 862719018805 phosphorylation site [posttranslational modification] 862719018806 intermolecular recognition site; other site 862719018807 dimerization interface [polypeptide binding]; other site 862719018808 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 862719018809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 862719018810 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 862719018811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 862719018812 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 862719018813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 862719018814 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 862719018815 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 862719018816 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 862719018817 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 862719018818 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 862719018819 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 862719018820 FeS/SAM binding site; other site 862719018821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719018822 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719018823 NAD(P) binding site [chemical binding]; other site 862719018824 active site 862719018825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719018826 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 862719018827 NAD(P) binding site [chemical binding]; other site 862719018828 active site 862719018829 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 862719018830 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 862719018831 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 862719018832 catalytic core [active] 862719018833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 862719018834 S-adenosylmethionine binding site [chemical binding]; other site 862719018835 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 862719018836 Ion channel; Region: Ion_trans_2; pfam07885 862719018837 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 862719018838 TrkA-N domain; Region: TrkA_N; pfam02254 862719018839 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 862719018840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 862719018841 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 862719018842 NlpC/P60 family; Region: NLPC_P60; cl17555 862719018843 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 862719018844 active site 862719018845 SAM binding site [chemical binding]; other site 862719018846 homodimer interface [polypeptide binding]; other site 862719018847 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 862719018848 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 862719018849 [4Fe-4S] binding site [ion binding]; other site 862719018850 molybdopterin cofactor binding site; other site 862719018851 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 862719018852 molybdopterin cofactor binding site; other site 862719018853 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 862719018854 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 862719018855 [2Fe-2S] cluster binding site [ion binding]; other site 862719018856 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 862719018857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 862719018858 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 862719018859 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 862719018860 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 862719018861 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 862719018862 NMT1-like family; Region: NMT1_2; pfam13379 862719018863 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 862719018864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719018865 dimer interface [polypeptide binding]; other site 862719018866 conserved gate region; other site 862719018867 putative PBP binding loops; other site 862719018868 ABC-ATPase subunit interface; other site 862719018869 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 862719018870 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 862719018871 Walker A/P-loop; other site 862719018872 ATP binding site [chemical binding]; other site 862719018873 Q-loop/lid; other site 862719018874 ABC transporter signature motif; other site 862719018875 Walker B; other site 862719018876 D-loop; other site 862719018877 H-loop/switch region; other site 862719018878 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 862719018879 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 862719018880 Walker A/P-loop; other site 862719018881 ATP binding site [chemical binding]; other site 862719018882 Q-loop/lid; other site 862719018883 ABC transporter signature motif; other site 862719018884 Walker B; other site 862719018885 D-loop; other site 862719018886 H-loop/switch region; other site 862719018887 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 862719018888 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 862719018889 active site 862719018890 catalytic tetrad [active] 862719018891 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 862719018892 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 862719018893 ATP binding site [chemical binding]; other site 862719018894 putative Mg++ binding site [ion binding]; other site 862719018895 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 862719018896 nucleotide binding region [chemical binding]; other site 862719018897 ATP-binding site [chemical binding]; other site 862719018898 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8763924; Product type e : enzyme 862719018899 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 862719018900 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 862719018901 putative active site [active] 862719018902 catalytic site [active] 862719018903 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 862719018904 putative active site [active] 862719018905 catalytic site [active] 862719018906 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 862719018907 active site 862719018908 catalytic residues [active] 862719018909 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719018910 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719018911 TM-ABC transporter signature motif; other site 862719018912 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719018913 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719018914 TM-ABC transporter signature motif; other site 862719018915 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 862719018916 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 862719018917 Walker A/P-loop; other site 862719018918 ATP binding site [chemical binding]; other site 862719018919 Q-loop/lid; other site 862719018920 ABC transporter signature motif; other site 862719018921 Walker B; other site 862719018922 D-loop; other site 862719018923 H-loop/switch region; other site 862719018924 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 862719018925 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 862719018926 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 862719018927 putative ligand binding site [chemical binding]; other site 862719018928 Gram-negative porin; Region: Porin_4; pfam13609 862719018929 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 862719018930 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 862719018931 dimer interface [polypeptide binding]; other site 862719018932 NADP binding site [chemical binding]; other site 862719018933 catalytic residues [active] 862719018934 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 862719018935 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 862719018936 inhibitor site; inhibition site 862719018937 active site 862719018938 dimer interface [polypeptide binding]; other site 862719018939 catalytic residue [active] 862719018940 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 862719018941 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 862719018942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 862719018943 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 862719018944 putative dimerization interface [polypeptide binding]; other site 862719018945 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 862719018946 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 862719018947 putative ligand binding site [chemical binding]; other site 862719018948 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 862719018949 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 862719018950 Walker A/P-loop; other site 862719018951 ATP binding site [chemical binding]; other site 862719018952 Q-loop/lid; other site 862719018953 ABC transporter signature motif; other site 862719018954 Walker B; other site 862719018955 D-loop; other site 862719018956 H-loop/switch region; other site 862719018957 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 862719018958 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719018959 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719018960 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 862719018961 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 862719018962 TM-ABC transporter signature motif; other site 862719018963 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 862719018964 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 862719018965 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 862719018966 conserved hypothetical protein; Region: MG423; TIGR00649 862719018967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 862719018968 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 862719018969 PAS domain S-box; Region: sensory_box; TIGR00229 862719018970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 862719018971 putative active site [active] 862719018972 heme pocket [chemical binding]; other site 862719018973 PAS fold; Region: PAS; pfam00989 862719018974 PAS domain; Region: PAS; smart00091 862719018975 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 862719018976 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 862719018977 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 862719018978 metal binding site [ion binding]; metal-binding site 862719018979 active site 862719018980 I-site; other site 862719018981 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 862719018982 Protein export membrane protein; Region: SecD_SecF; cl14618 862719018983 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 862719018984 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719018985 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719018986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719018987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719018988 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719018989 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 862719018990 Ligand Binding Site [chemical binding]; other site 862719018991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719018992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719018993 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 862719018994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719018995 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 862719018996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 862719018997 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719018998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719018999 dimer interface [polypeptide binding]; other site 862719019000 conserved gate region; other site 862719019001 putative PBP binding loops; other site 862719019002 ABC-ATPase subunit interface; other site 862719019003 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 862719019004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 862719019005 dimer interface [polypeptide binding]; other site 862719019006 conserved gate region; other site 862719019007 putative PBP binding loops; other site 862719019008 ABC-ATPase subunit interface; other site 862719019009 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 862719019010 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 862719019011 substrate binding pocket [chemical binding]; other site 862719019012 membrane-bound complex binding site; other site 862719019013 hinge residues; other site 862719019014 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 862719019015 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 862719019016 Walker A/P-loop; other site 862719019017 ATP binding site [chemical binding]; other site 862719019018 Q-loop/lid; other site 862719019019 ABC transporter signature motif; other site 862719019020 Walker B; other site 862719019021 D-loop; other site 862719019022 H-loop/switch region; other site 862719019023 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 862719019024 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 862719019025 putative ligand binding site [chemical binding]; other site 862719019026 NAD binding site [chemical binding]; other site 862719019027 catalytic site [active] 862719019028 Transcriptional regulators [Transcription]; Region: PurR; COG1609 862719019029 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 862719019030 DNA binding site [nucleotide binding] 862719019031 domain linker motif; other site 862719019032 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 862719019033 putative dimerization interface [polypeptide binding]; other site 862719019034 putative ligand binding site [chemical binding]; other site 862719019035 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 862719019036 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 862719019037 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 862719019038 DNA binding residues [nucleotide binding] 862719019039 dimer interface [polypeptide binding]; other site 862719019040 [2Fe-2S] cluster binding site [ion binding]; other site 862719019041 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 862719019042 HPP family; Region: HPP; pfam04982 862719019043 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 862719019044 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 862719019045 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 862719019046 Cation efflux family; Region: Cation_efflux; pfam01545 862719019047 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 862719019048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 862719019049 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 862719019050 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719019051 P-loop; other site 862719019052 Magnesium ion binding site [ion binding]; other site 862719019053 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 862719019054 Magnesium ion binding site [ion binding]; other site 862719019055 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 862719019056 ParB-like nuclease domain; Region: ParB; smart00470 862719019057 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 862719019058 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 862719019059 heme binding pocket [chemical binding]; other site 862719019060 malonyl-CoA synthase; Validated; Region: PRK07514 862719019061 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 862719019062 acyl-activating enzyme (AAE) consensus motif; other site 862719019063 active site 862719019064 AMP binding site [chemical binding]; other site 862719019065 CoA binding site [chemical binding]; other site 862719019066 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 862719019067 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 862719019068 NodB motif; other site 862719019069 active site 862719019070 catalytic site [active] 862719019071 metal binding site [ion binding]; metal-binding site 862719019072 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 862719019073 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 862719019074 Histidine kinase; Region: His_kinase; pfam06580 862719019075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719019076 ATP binding site [chemical binding]; other site 862719019077 Mg2+ binding site [ion binding]; other site 862719019078 G-X-G motif; other site 862719019079 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 862719019080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719019081 active site 862719019082 phosphorylation site [posttranslational modification] 862719019083 intermolecular recognition site; other site 862719019084 dimerization interface [polypeptide binding]; other site 862719019085 LytTr DNA-binding domain; Region: LytTR; pfam04397 862719019086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 862719019087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 862719019088 potential frameshift: common BLAST hit: gi|288962344|ref|YP_003452639.1| secretion protein 862719019089 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 862719019090 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 862719019091 HlyD family secretion protein; Region: HlyD_3; pfam13437 862719019092 multidrug efflux protein; Reviewed; Region: PRK09579 862719019093 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 862719019094 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 862719019095 Right handed beta helix region; Region: Beta_helix; pfam13229 862719019096 Right handed beta helix region; Region: Beta_helix; pfam13229 862719019097 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 862719019098 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 862719019099 Protein of unknown function (DUF466); Region: DUF466; cl01082 862719019100 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 862719019101 Carbon starvation protein CstA; Region: CstA; pfam02554 862719019102 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 862719019103 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 862719019104 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 862719019105 HflX GTPase family; Region: HflX; cd01878 862719019106 G1 box; other site 862719019107 GTP/Mg2+ binding site [chemical binding]; other site 862719019108 Switch I region; other site 862719019109 G2 box; other site 862719019110 G3 box; other site 862719019111 Switch II region; other site 862719019112 G4 box; other site 862719019113 G5 box; other site 862719019114 L-lactate permease; Region: Lactate_perm; cl00701 862719019115 L-lactate permease; Region: Lactate_perm; cl00701 862719019116 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 862719019117 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 862719019118 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 862719019119 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 862719019120 Soluble P-type ATPase [General function prediction only]; Region: COG4087 862719019121 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 862719019122 PAS fold; Region: PAS_4; pfam08448 862719019123 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 862719019124 GAF domain; Region: GAF; pfam01590 862719019125 PAS domain; Region: PAS_9; pfam13426 862719019126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 862719019127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 862719019128 dimer interface [polypeptide binding]; other site 862719019129 phosphorylation site [posttranslational modification] 862719019130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 862719019131 ATP binding site [chemical binding]; other site 862719019132 G-X-G motif; other site 862719019133 Response regulator receiver domain; Region: Response_reg; pfam00072 862719019134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 862719019135 active site 862719019136 phosphorylation site [posttranslational modification] 862719019137 intermolecular recognition site; other site 862719019138 dimerization interface [polypeptide binding]; other site 862719019139 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 862719019140 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 862719019141 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 862719019142 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858