-- dump date 20140618_210508 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1283331000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1283331000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1283331000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331000004 Walker A motif; other site 1283331000005 ATP binding site [chemical binding]; other site 1283331000006 Walker B motif; other site 1283331000007 arginine finger; other site 1283331000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1283331000009 DnaA box-binding interface [nucleotide binding]; other site 1283331000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1283331000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1283331000012 putative DNA binding surface [nucleotide binding]; other site 1283331000013 dimer interface [polypeptide binding]; other site 1283331000014 beta-clamp/clamp loader binding surface; other site 1283331000015 beta-clamp/translesion DNA polymerase binding surface; other site 1283331000016 recombination protein F; Reviewed; Region: recF; PRK00064 1283331000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331000018 Walker A/P-loop; other site 1283331000019 ATP binding site [chemical binding]; other site 1283331000020 Q-loop/lid; other site 1283331000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331000022 ABC transporter signature motif; other site 1283331000023 Walker B; other site 1283331000024 D-loop; other site 1283331000025 H-loop/switch region; other site 1283331000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1283331000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331000028 Mg2+ binding site [ion binding]; other site 1283331000029 G-X-G motif; other site 1283331000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1283331000031 anchoring element; other site 1283331000032 dimer interface [polypeptide binding]; other site 1283331000033 ATP binding site [chemical binding]; other site 1283331000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1283331000035 active site 1283331000036 putative metal-binding site [ion binding]; other site 1283331000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1283331000038 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1283331000039 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 1283331000040 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1283331000041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1283331000042 putative acyl-acceptor binding pocket; other site 1283331000043 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1283331000044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331000045 active site 1283331000046 motif I; other site 1283331000047 motif II; other site 1283331000048 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1283331000049 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1283331000050 dimer interface [polypeptide binding]; other site 1283331000051 motif 1; other site 1283331000052 active site 1283331000053 motif 2; other site 1283331000054 motif 3; other site 1283331000055 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1283331000056 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1283331000057 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1283331000058 putative active site [active] 1283331000059 putative metal binding site [ion binding]; other site 1283331000060 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1283331000061 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1283331000062 TrkA-N domain; Region: TrkA_N; pfam02254 1283331000063 TrkA-C domain; Region: TrkA_C; pfam02080 1283331000064 TrkA-N domain; Region: TrkA_N; pfam02254 1283331000065 TrkA-C domain; Region: TrkA_C; pfam02080 1283331000066 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1283331000067 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1283331000068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331000069 S-adenosylmethionine binding site [chemical binding]; other site 1283331000070 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1283331000071 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1283331000072 putative active site [active] 1283331000073 substrate binding site [chemical binding]; other site 1283331000074 putative cosubstrate binding site; other site 1283331000075 catalytic site [active] 1283331000076 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1283331000077 substrate binding site [chemical binding]; other site 1283331000078 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1283331000079 active site 1283331000080 catalytic residues [active] 1283331000081 metal binding site [ion binding]; metal-binding site 1283331000082 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1283331000083 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1283331000084 DNA protecting protein DprA; Region: dprA; TIGR00732 1283331000085 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1283331000086 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1283331000087 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1283331000088 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1283331000089 NADP binding site [chemical binding]; other site 1283331000090 dimer interface [polypeptide binding]; other site 1283331000091 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1283331000092 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1283331000093 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1283331000094 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1283331000095 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1283331000096 shikimate binding site; other site 1283331000097 NAD(P) binding site [chemical binding]; other site 1283331000098 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1283331000099 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1283331000100 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1283331000101 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1283331000102 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1283331000103 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1283331000104 MgtC family; Region: MgtC; pfam02308 1283331000105 Hemerythrin-like domain; Region: Hr-like; cd12108 1283331000106 Fe binding site [ion binding]; other site 1283331000107 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 1283331000108 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1283331000109 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1283331000110 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283331000111 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1283331000112 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 1283331000113 Cytochrome c; Region: Cytochrom_C; cl11414 1283331000114 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331000115 metal binding site [ion binding]; metal-binding site 1283331000116 active site 1283331000117 I-site; other site 1283331000118 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1283331000119 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283331000120 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1283331000121 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1283331000122 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1283331000123 dimerization interface [polypeptide binding]; other site 1283331000124 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1283331000125 heme-binding site [chemical binding]; other site 1283331000126 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331000127 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331000128 metal binding site [ion binding]; metal-binding site 1283331000129 active site 1283331000130 I-site; other site 1283331000131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1283331000132 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1283331000133 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1283331000134 putative ligand binding residues [chemical binding]; other site 1283331000135 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1283331000136 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283331000137 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1283331000138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1283331000139 Walker A/P-loop; other site 1283331000140 ATP binding site [chemical binding]; other site 1283331000141 Q-loop/lid; other site 1283331000142 ABC transporter signature motif; other site 1283331000143 Walker B; other site 1283331000144 D-loop; other site 1283331000145 H-loop/switch region; other site 1283331000146 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1283331000147 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1283331000148 ligand-binding site [chemical binding]; other site 1283331000149 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1283331000150 Part of AAA domain; Region: AAA_19; pfam13245 1283331000151 Family description; Region: UvrD_C_2; pfam13538 1283331000152 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331000153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331000154 metal binding site [ion binding]; metal-binding site 1283331000155 active site 1283331000156 I-site; other site 1283331000157 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283331000158 putative protease; Provisional; Region: PRK15452 1283331000159 Peptidase family U32; Region: Peptidase_U32; pfam01136 1283331000160 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283331000161 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1283331000162 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283331000163 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1283331000164 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1283331000165 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283331000166 Walker A/P-loop; other site 1283331000167 ATP binding site [chemical binding]; other site 1283331000168 Q-loop/lid; other site 1283331000169 ABC transporter signature motif; other site 1283331000170 Walker B; other site 1283331000171 D-loop; other site 1283331000172 H-loop/switch region; other site 1283331000173 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1283331000174 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283331000175 Walker A/P-loop; other site 1283331000176 ATP binding site [chemical binding]; other site 1283331000177 Q-loop/lid; other site 1283331000178 ABC transporter signature motif; other site 1283331000179 Walker B; other site 1283331000180 D-loop; other site 1283331000181 H-loop/switch region; other site 1283331000182 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1283331000183 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283331000184 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331000185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283331000186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331000187 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1283331000188 DNA polymerase I; Provisional; Region: PRK05755 1283331000189 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1283331000190 active site 1283331000191 metal binding site 1 [ion binding]; metal-binding site 1283331000192 putative 5' ssDNA interaction site; other site 1283331000193 metal binding site 3; metal-binding site 1283331000194 metal binding site 2 [ion binding]; metal-binding site 1283331000195 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1283331000196 putative DNA binding site [nucleotide binding]; other site 1283331000197 putative metal binding site [ion binding]; other site 1283331000198 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1283331000199 active site 1283331000200 catalytic site [active] 1283331000201 substrate binding site [chemical binding]; other site 1283331000202 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1283331000203 active site 1283331000204 DNA binding site [nucleotide binding] 1283331000205 catalytic site [active] 1283331000206 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1283331000207 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1283331000208 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1283331000209 putative active site [active] 1283331000210 putative substrate binding site [chemical binding]; other site 1283331000211 ATP binding site [chemical binding]; other site 1283331000212 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283331000213 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283331000214 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 1283331000215 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1283331000216 active site 1283331000217 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1283331000218 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331000219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331000220 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1283331000221 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1283331000222 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1283331000223 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1283331000224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1283331000225 Probable transposase; Region: OrfB_IS605; pfam01385 1283331000226 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1283331000227 Membrane bound O-acyl transferase family; Region: MBOAT_2; pfam13813 1283331000228 Isochorismatase family; Region: Isochorismatase; pfam00857 1283331000229 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1283331000230 catalytic triad [active] 1283331000231 conserved cis-peptide bond; other site 1283331000232 TSCPD domain; Region: TSCPD; pfam12637 1283331000233 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1283331000234 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1283331000235 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1283331000236 active site 1283331000237 dimer interface [polypeptide binding]; other site 1283331000238 effector binding site; other site 1283331000239 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1283331000240 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1283331000241 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1283331000242 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1283331000243 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1283331000244 metal binding site [ion binding]; metal-binding site 1283331000245 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1283331000246 metal binding site 2 [ion binding]; metal-binding site 1283331000247 putative DNA binding helix; other site 1283331000248 metal binding site 1 [ion binding]; metal-binding site 1283331000249 dimer interface [polypeptide binding]; other site 1283331000250 structural Zn2+ binding site [ion binding]; other site 1283331000251 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1283331000252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331000253 Walker A/P-loop; other site 1283331000254 ATP binding site [chemical binding]; other site 1283331000255 Q-loop/lid; other site 1283331000256 ABC transporter signature motif; other site 1283331000257 Walker B; other site 1283331000258 D-loop; other site 1283331000259 H-loop/switch region; other site 1283331000260 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1283331000261 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1283331000262 dimer interface [polypeptide binding]; other site 1283331000263 putative PBP binding regions; other site 1283331000264 ABC-ATPase subunit interface; other site 1283331000265 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1283331000266 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1283331000267 putative NAD(P) binding site [chemical binding]; other site 1283331000268 putative substrate binding site [chemical binding]; other site 1283331000269 catalytic Zn binding site [ion binding]; other site 1283331000270 structural Zn binding site [ion binding]; other site 1283331000271 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1283331000272 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1283331000273 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1283331000274 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283331000275 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283331000276 Cytochrome c; Region: Cytochrom_C; pfam00034 1283331000277 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331000278 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1283331000279 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1283331000280 Cu(I) binding site [ion binding]; other site 1283331000281 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1283331000282 UbiA prenyltransferase family; Region: UbiA; pfam01040 1283331000283 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1283331000284 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1283331000285 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1283331000286 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1283331000287 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1283331000288 Subunit III/VIIa interface [polypeptide binding]; other site 1283331000289 Phospholipid binding site [chemical binding]; other site 1283331000290 Subunit I/III interface [polypeptide binding]; other site 1283331000291 Subunit III/VIb interface [polypeptide binding]; other site 1283331000292 Subunit III/VIa interface; other site 1283331000293 Subunit III/Vb interface [polypeptide binding]; other site 1283331000294 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1283331000295 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 1283331000296 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1283331000297 Subunit I/III interface [polypeptide binding]; other site 1283331000298 D-pathway; other site 1283331000299 Subunit I/VIIc interface [polypeptide binding]; other site 1283331000300 Subunit I/IV interface [polypeptide binding]; other site 1283331000301 Subunit I/II interface [polypeptide binding]; other site 1283331000302 Low-spin heme (heme a) binding site [chemical binding]; other site 1283331000303 Subunit I/VIIa interface [polypeptide binding]; other site 1283331000304 Subunit I/VIa interface [polypeptide binding]; other site 1283331000305 Dimer interface; other site 1283331000306 Putative water exit pathway; other site 1283331000307 Binuclear center (heme a3/CuB) [ion binding]; other site 1283331000308 K-pathway; other site 1283331000309 Subunit I/Vb interface [polypeptide binding]; other site 1283331000310 Putative proton exit pathway; other site 1283331000311 Subunit I/VIb interface; other site 1283331000312 Subunit I/VIc interface [polypeptide binding]; other site 1283331000313 Electron transfer pathway; other site 1283331000314 Subunit I/VIIIb interface [polypeptide binding]; other site 1283331000315 Subunit I/VIIb interface [polypeptide binding]; other site 1283331000316 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1283331000317 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1283331000318 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1283331000319 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283331000320 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1283331000321 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1283331000322 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1283331000323 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1283331000324 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1283331000325 active site clefts [active] 1283331000326 zinc binding site [ion binding]; other site 1283331000327 dimer interface [polypeptide binding]; other site 1283331000328 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 1283331000329 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1283331000330 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1283331000331 active site 1283331000332 Zn binding site [ion binding]; other site 1283331000333 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1283331000334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331000335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331000336 DNA binding residues [nucleotide binding] 1283331000337 fec operon regulator FecR; Reviewed; Region: PRK09774 1283331000338 FecR protein; Region: FecR; pfam04773 1283331000339 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283331000340 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283331000341 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331000342 N-terminal plug; other site 1283331000343 ligand-binding site [chemical binding]; other site 1283331000344 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1283331000345 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1283331000346 trimer interface [polypeptide binding]; other site 1283331000347 putative metal binding site [ion binding]; other site 1283331000348 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1283331000349 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 1283331000350 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1283331000351 active site 1283331000352 homodimer interface [polypeptide binding]; other site 1283331000353 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1283331000354 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1283331000355 ATP-grasp domain; Region: ATP-grasp; pfam02222 1283331000356 Predicted membrane protein [Function unknown]; Region: COG2261 1283331000357 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1283331000358 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1283331000359 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1283331000360 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331000361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331000362 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1283331000363 Walker A/P-loop; other site 1283331000364 ATP binding site [chemical binding]; other site 1283331000365 Q-loop/lid; other site 1283331000366 ABC transporter signature motif; other site 1283331000367 Walker B; other site 1283331000368 D-loop; other site 1283331000369 H-loop/switch region; other site 1283331000370 TOBE domain; Region: TOBE; cl01440 1283331000371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331000372 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1283331000373 dimer interface [polypeptide binding]; other site 1283331000374 conserved gate region; other site 1283331000375 putative PBP binding loops; other site 1283331000376 ABC-ATPase subunit interface; other site 1283331000377 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1283331000378 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1283331000379 Hemerythrin; Region: Hemerythrin; cd12107 1283331000380 Fe binding site [ion binding]; other site 1283331000381 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1283331000382 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 1283331000383 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1283331000384 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1283331000385 putative acyl-acceptor binding pocket; other site 1283331000386 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283331000387 acyl-activating enzyme (AAE) consensus motif; other site 1283331000388 AMP binding site [chemical binding]; other site 1283331000389 active site 1283331000390 CoA binding site [chemical binding]; other site 1283331000391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331000392 non-specific DNA binding site [nucleotide binding]; other site 1283331000393 salt bridge; other site 1283331000394 sequence-specific DNA binding site [nucleotide binding]; other site 1283331000395 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1283331000396 nitrogenase iron protein; Region: nifH; TIGR01287 1283331000397 Nucleotide-binding sites [chemical binding]; other site 1283331000398 Walker A motif; other site 1283331000399 Switch I region of nucleotide binding site; other site 1283331000400 Fe4S4 binding sites [ion binding]; other site 1283331000401 Switch II region of nucleotide binding site; other site 1283331000402 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1283331000403 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1283331000404 MoFe protein alpha/beta subunit interactions; other site 1283331000405 Alpha subunit P cluster binding residues; other site 1283331000406 FeMoco binding residues [chemical binding]; other site 1283331000407 MoFe protein alpha subunit/Fe protein contacts; other site 1283331000408 MoFe protein dimer/ dimer interactions; other site 1283331000409 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1283331000410 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1283331000411 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1283331000412 MoFe protein beta/alpha subunit interactions; other site 1283331000413 Beta subunit P cluster binding residues; other site 1283331000414 MoFe protein beta subunit/Fe protein contacts; other site 1283331000415 MoFe protein dimer/ dimer interactions; other site 1283331000416 NifT/FixU protein; Region: NifT; pfam06988 1283331000417 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1283331000418 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 1283331000419 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1283331000420 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 1283331000421 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1283331000422 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1283331000423 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1283331000424 probable nitrogen fixation protein; Region: TIGR02935 1283331000425 Rop-like; Region: Rop-like; pfam05082 1283331000426 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 1283331000427 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1283331000428 dimer interface [polypeptide binding]; other site 1283331000429 [2Fe-2S] cluster binding site [ion binding]; other site 1283331000430 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 1283331000431 Domain of unknown function (DUF364); Region: DUF364; pfam04016 1283331000432 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1283331000433 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1283331000434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331000435 Walker A/P-loop; other site 1283331000436 ATP binding site [chemical binding]; other site 1283331000437 Q-loop/lid; other site 1283331000438 ABC transporter signature motif; other site 1283331000439 Walker B; other site 1283331000440 D-loop; other site 1283331000441 H-loop/switch region; other site 1283331000442 TOBE domain; Region: TOBE; pfam03459 1283331000443 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1283331000444 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 1283331000445 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1283331000446 trimerization site [polypeptide binding]; other site 1283331000447 active site 1283331000448 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1283331000449 NifU-like domain; Region: NifU; pfam01106 1283331000450 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1283331000451 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1283331000452 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283331000453 catalytic residue [active] 1283331000454 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 1283331000455 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 1283331000456 active site 1283331000457 catalytic residues [active] 1283331000458 metal binding site [ion binding]; metal-binding site 1283331000459 serine O-acetyltransferase; Region: cysE; TIGR01172 1283331000460 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1283331000461 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1283331000462 trimer interface [polypeptide binding]; other site 1283331000463 active site 1283331000464 substrate binding site [chemical binding]; other site 1283331000465 CoA binding site [chemical binding]; other site 1283331000466 Nitrogen fixation protein NifW; Region: NifW; pfam03206 1283331000467 NifZ domain; Region: NifZ; pfam04319 1283331000468 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 1283331000469 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1283331000470 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1283331000471 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1283331000472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331000473 Walker A motif; other site 1283331000474 ATP binding site [chemical binding]; other site 1283331000475 Walker B motif; other site 1283331000476 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1283331000477 flavodoxin FldA; Validated; Region: PRK09267 1283331000478 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1283331000479 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1283331000480 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1283331000481 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1283331000482 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1283331000483 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1283331000484 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1283331000485 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1283331000486 Membrane transport protein; Region: Mem_trans; cl09117 1283331000487 Membrane transport protein; Region: Mem_trans; cl09117 1283331000488 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1283331000489 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 1283331000490 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1283331000491 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1283331000492 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1283331000493 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1283331000494 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1283331000495 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1283331000496 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1283331000497 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1283331000498 ligand binding site [chemical binding]; other site 1283331000499 homodimer interface [polypeptide binding]; other site 1283331000500 NAD(P) binding site [chemical binding]; other site 1283331000501 trimer interface B [polypeptide binding]; other site 1283331000502 trimer interface A [polypeptide binding]; other site 1283331000503 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1283331000504 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331000505 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1283331000506 Protein export membrane protein; Region: SecD_SecF; cl14618 1283331000507 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1283331000508 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1283331000509 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1283331000510 Predicted transporter component [General function prediction only]; Region: COG2391 1283331000511 Sulphur transport; Region: Sulf_transp; pfam04143 1283331000512 Predicted transporter component [General function prediction only]; Region: COG2391 1283331000513 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1283331000514 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1283331000515 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1283331000516 amidase catalytic site [active] 1283331000517 Zn binding residues [ion binding]; other site 1283331000518 substrate binding site [chemical binding]; other site 1283331000519 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1283331000520 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1283331000521 putative catalytic site [active] 1283331000522 putative metal binding site [ion binding]; other site 1283331000523 putative phosphate binding site [ion binding]; other site 1283331000524 putative catalytic site [active] 1283331000525 putative phosphate binding site [ion binding]; other site 1283331000526 putative metal binding site [ion binding]; other site 1283331000527 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1283331000528 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1283331000529 catalytic residues [active] 1283331000530 hinge region; other site 1283331000531 alpha helical domain; other site 1283331000532 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1283331000533 Cytochrome c; Region: Cytochrom_C; cl11414 1283331000534 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1283331000535 G1 box; other site 1283331000536 GTP/Mg2+ binding site [chemical binding]; other site 1283331000537 Switch I region; other site 1283331000538 G2 box; other site 1283331000539 G3 box; other site 1283331000540 Switch II region; other site 1283331000541 G4 box; other site 1283331000542 G5 box; other site 1283331000543 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1283331000544 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1283331000545 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1283331000546 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1283331000547 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1283331000548 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1283331000549 putative active site [active] 1283331000550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331000551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331000552 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1283331000553 putative dimerization interface [polypeptide binding]; other site 1283331000554 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1283331000555 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1283331000556 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1283331000557 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1283331000558 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1283331000559 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1283331000560 active site 1283331000561 catalytic residues [active] 1283331000562 metal binding site [ion binding]; metal-binding site 1283331000563 homodimer binding site [polypeptide binding]; other site 1283331000564 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1283331000565 carboxyltransferase (CT) interaction site; other site 1283331000566 biotinylation site [posttranslational modification]; other site 1283331000567 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1283331000568 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1283331000569 Dodecin; Region: Dodecin; pfam07311 1283331000570 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1283331000571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331000572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331000573 dimerization interface [polypeptide binding]; other site 1283331000574 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1283331000575 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1283331000576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331000577 catalytic residue [active] 1283331000578 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1283331000579 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1283331000580 substrate binding site [chemical binding]; other site 1283331000581 active site 1283331000582 catalytic residues [active] 1283331000583 heterodimer interface [polypeptide binding]; other site 1283331000584 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1283331000585 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1283331000586 HSP70 interaction site [polypeptide binding]; other site 1283331000587 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1283331000588 substrate binding site [polypeptide binding]; other site 1283331000589 dimer interface [polypeptide binding]; other site 1283331000590 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1283331000591 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1283331000592 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283331000593 Cupin domain; Region: Cupin_2; cl17218 1283331000594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331000595 Helix-turn-helix domain; Region: HTH_18; pfam12833 1283331000596 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283331000597 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283331000598 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331000599 N-terminal plug; other site 1283331000600 ligand-binding site [chemical binding]; other site 1283331000601 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283331000602 FecR protein; Region: FecR; pfam04773 1283331000603 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1283331000604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331000605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331000606 DNA binding residues [nucleotide binding] 1283331000607 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1283331000608 active site 1283331000609 General stress protein [General function prediction only]; Region: GsiB; COG3729 1283331000610 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1283331000611 CsbD-like; Region: CsbD; pfam05532 1283331000612 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1283331000613 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1283331000614 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1283331000615 DNA binding residues [nucleotide binding] 1283331000616 putative dimer interface [polypeptide binding]; other site 1283331000617 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283331000618 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283331000619 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283331000620 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1283331000621 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1283331000622 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1283331000623 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1283331000624 putative FMN binding site [chemical binding]; other site 1283331000625 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283331000626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331000627 Walker A/P-loop; other site 1283331000628 ATP binding site [chemical binding]; other site 1283331000629 Q-loop/lid; other site 1283331000630 ABC transporter signature motif; other site 1283331000631 Walker B; other site 1283331000632 D-loop; other site 1283331000633 H-loop/switch region; other site 1283331000634 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283331000635 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1283331000636 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1283331000637 active site 1283331000638 catalytic residues [active] 1283331000639 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1283331000640 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1283331000641 active site 1283331000642 catalytic site [active] 1283331000643 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1283331000644 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1283331000645 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 1283331000646 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1283331000647 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283331000648 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1283331000649 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1283331000650 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1283331000651 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1283331000652 active site 1283331000653 NTP binding site [chemical binding]; other site 1283331000654 metal binding triad [ion binding]; metal-binding site 1283331000655 antibiotic binding site [chemical binding]; other site 1283331000656 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 1283331000657 thymidylate kinase; Provisional; Region: PRK13975; cl17243 1283331000658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 1283331000659 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1283331000660 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1283331000661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331000662 dimer interface [polypeptide binding]; other site 1283331000663 conserved gate region; other site 1283331000664 ABC-ATPase subunit interface; other site 1283331000665 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 1283331000666 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1283331000667 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1283331000668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331000669 Walker A/P-loop; other site 1283331000670 ATP binding site [chemical binding]; other site 1283331000671 Q-loop/lid; other site 1283331000672 ABC transporter signature motif; other site 1283331000673 Walker B; other site 1283331000674 D-loop; other site 1283331000675 H-loop/switch region; other site 1283331000676 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1283331000677 Nitrogenase_VFe_beta -like: Nitrogenase VFe protein, beta subunit like. This group contains proteins similar to the beta subunits of the VFe protein of the vanadium-dependent (V-) nitrogenase. Nitrogenase catalyzes the ATP-dependent reduction of...; Region: Nitrogenase_VFe_beta_like; cd01973 1283331000678 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1283331000679 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 1283331000680 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 1283331000681 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 1283331000682 hypothetical protein; Provisional; Region: PRK13795 1283331000683 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1283331000684 nitrogenase iron protein; Region: nifH; TIGR01287 1283331000685 Nucleotide-binding sites [chemical binding]; other site 1283331000686 Walker A motif; other site 1283331000687 Switch I region of nucleotide binding site; other site 1283331000688 Fe4S4 binding sites [ion binding]; other site 1283331000689 Switch II region of nucleotide binding site; other site 1283331000690 benzoate transport; Region: 2A0115; TIGR00895 1283331000691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331000692 putative substrate translocation pore; other site 1283331000693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331000694 hypothetical protein; Validated; Region: PRK07411 1283331000695 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1283331000696 ATP binding site [chemical binding]; other site 1283331000697 substrate interface [chemical binding]; other site 1283331000698 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1283331000699 active site residue [active] 1283331000700 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 1283331000701 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1283331000702 ATP binding site [chemical binding]; other site 1283331000703 substrate interface [chemical binding]; other site 1283331000704 Ubiquitin-like proteins; Region: UBQ; cl00155 1283331000705 charged pocket; other site 1283331000706 hydrophobic patch; other site 1283331000707 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1283331000708 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1283331000709 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1283331000710 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1283331000711 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1283331000712 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1283331000713 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283331000714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331000715 Walker A motif; other site 1283331000716 ATP binding site [chemical binding]; other site 1283331000717 Walker B motif; other site 1283331000718 arginine finger; other site 1283331000719 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331000720 NifU-like domain; Region: NifU; pfam01106 1283331000721 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1283331000722 homotrimer interaction site [polypeptide binding]; other site 1283331000723 putative active site [active] 1283331000724 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1283331000725 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283331000726 Zn2+ binding site [ion binding]; other site 1283331000727 Mg2+ binding site [ion binding]; other site 1283331000728 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1283331000729 synthetase active site [active] 1283331000730 NTP binding site [chemical binding]; other site 1283331000731 metal binding site [ion binding]; metal-binding site 1283331000732 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1283331000733 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1283331000734 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1283331000735 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1283331000736 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1283331000737 catalytic site [active] 1283331000738 G-X2-G-X-G-K; other site 1283331000739 hypothetical protein; Provisional; Region: PRK11820 1283331000740 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1283331000741 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1283331000742 ribonuclease PH; Reviewed; Region: rph; PRK00173 1283331000743 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1283331000744 hexamer interface [polypeptide binding]; other site 1283331000745 active site 1283331000746 Tic20-like protein; Region: Tic20; pfam09685 1283331000747 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1283331000748 putative active site [active] 1283331000749 putative catalytic site [active] 1283331000750 putative DNA binding site [nucleotide binding]; other site 1283331000751 putative phosphate binding site [ion binding]; other site 1283331000752 metal binding site A [ion binding]; metal-binding site 1283331000753 putative AP binding site [nucleotide binding]; other site 1283331000754 putative metal binding site B [ion binding]; other site 1283331000755 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331000756 active site 1283331000757 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 1283331000758 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1283331000759 feedback inhibition sensing region; other site 1283331000760 homohexameric interface [polypeptide binding]; other site 1283331000761 nucleotide binding site [chemical binding]; other site 1283331000762 N-acetyl-L-glutamate binding site [chemical binding]; other site 1283331000763 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1283331000764 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1283331000765 active site 1283331000766 substrate binding site [chemical binding]; other site 1283331000767 metal binding site [ion binding]; metal-binding site 1283331000768 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1283331000769 trimer interface [polypeptide binding]; other site 1283331000770 active site 1283331000771 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1283331000772 Flavoprotein; Region: Flavoprotein; pfam02441 1283331000773 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1283331000774 hypothetical protein; Reviewed; Region: PRK00024 1283331000775 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1283331000776 MPN+ (JAMM) motif; other site 1283331000777 Zinc-binding site [ion binding]; other site 1283331000778 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1283331000779 Transglycosylase; Region: Transgly; cl17702 1283331000780 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1283331000781 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1283331000782 thiS-thiF/thiG interaction site; other site 1283331000783 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1283331000784 ThiS interaction site; other site 1283331000785 putative active site [active] 1283331000786 tetramer interface [polypeptide binding]; other site 1283331000787 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1283331000788 HemN family oxidoreductase; Provisional; Region: PRK05660 1283331000789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331000790 FeS/SAM binding site; other site 1283331000791 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1283331000792 active site 1283331000793 dimerization interface [polypeptide binding]; other site 1283331000794 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 1283331000795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331000796 S-adenosylmethionine binding site [chemical binding]; other site 1283331000797 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1283331000798 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1283331000799 hypothetical protein; Validated; Region: PRK05090 1283331000800 YGGT family; Region: YGGT; pfam02325 1283331000801 YGGT family; Region: YGGT; pfam02325 1283331000802 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1283331000803 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1283331000804 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1283331000805 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283331000806 catalytic residue [active] 1283331000807 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1283331000808 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1283331000809 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1283331000810 Walker A motif; other site 1283331000811 ATP binding site [chemical binding]; other site 1283331000812 Walker B motif; other site 1283331000813 TM2 domain; Region: TM2; pfam05154 1283331000814 dihydroorotase; Validated; Region: pyrC; PRK09357 1283331000815 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1283331000816 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1283331000817 active site 1283331000818 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1283331000819 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1283331000820 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1283331000821 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1283331000822 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331000823 active site 1283331000824 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1283331000825 hypothetical protein; Validated; Region: PRK00228 1283331000826 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1283331000827 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283331000828 glutathione synthetase; Provisional; Region: PRK05246 1283331000829 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1283331000830 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1283331000831 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331000832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331000833 active site 1283331000834 phosphorylation site [posttranslational modification] 1283331000835 intermolecular recognition site; other site 1283331000836 dimerization interface [polypeptide binding]; other site 1283331000837 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1283331000838 RNA methyltransferase, RsmE family; Region: TIGR00046 1283331000839 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 1283331000840 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 1283331000841 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283331000842 inhibitor-cofactor binding pocket; inhibition site 1283331000843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331000844 catalytic residue [active] 1283331000845 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1283331000846 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1283331000847 hypothetical protein; Provisional; Region: PRK03757 1283331000848 Cache domain; Region: Cache_1; pfam02743 1283331000849 PAS fold; Region: PAS_3; pfam08447 1283331000850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331000851 putative active site [active] 1283331000852 heme pocket [chemical binding]; other site 1283331000853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331000854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331000855 dimer interface [polypeptide binding]; other site 1283331000856 phosphorylation site [posttranslational modification] 1283331000857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331000858 ATP binding site [chemical binding]; other site 1283331000859 Mg2+ binding site [ion binding]; other site 1283331000860 G-X-G motif; other site 1283331000861 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331000862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331000863 active site 1283331000864 phosphorylation site [posttranslational modification] 1283331000865 intermolecular recognition site; other site 1283331000866 dimerization interface [polypeptide binding]; other site 1283331000867 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1283331000868 active site 1283331000869 metal binding site [ion binding]; metal-binding site 1283331000870 homotetramer interface [polypeptide binding]; other site 1283331000871 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1283331000872 HipA N-terminal domain; Region: Couple_hipA; cl11853 1283331000873 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1283331000874 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1283331000875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1283331000876 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1283331000877 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1283331000878 putative RNA binding site [nucleotide binding]; other site 1283331000879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331000880 S-adenosylmethionine binding site [chemical binding]; other site 1283331000881 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283331000882 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1283331000883 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1283331000884 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283331000885 Walker A/P-loop; other site 1283331000886 ATP binding site [chemical binding]; other site 1283331000887 Q-loop/lid; other site 1283331000888 ABC transporter signature motif; other site 1283331000889 Walker B; other site 1283331000890 D-loop; other site 1283331000891 H-loop/switch region; other site 1283331000892 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283331000893 dimer interface [polypeptide binding]; other site 1283331000894 putative CheW interface [polypeptide binding]; other site 1283331000895 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1283331000896 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1283331000897 proposed catalytic triad [active] 1283331000898 conserved cys residue [active] 1283331000899 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1283331000900 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1283331000901 DNA binding site [nucleotide binding] 1283331000902 catalytic residue [active] 1283331000903 H2TH interface [polypeptide binding]; other site 1283331000904 putative catalytic residues [active] 1283331000905 turnover-facilitating residue; other site 1283331000906 intercalation triad [nucleotide binding]; other site 1283331000907 8OG recognition residue [nucleotide binding]; other site 1283331000908 putative reading head residues; other site 1283331000909 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1283331000910 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1283331000911 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1283331000912 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1283331000913 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1283331000914 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1283331000915 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1283331000916 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1283331000917 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1283331000918 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1283331000919 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1283331000920 active site 1283331000921 (T/H)XGH motif; other site 1283331000922 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1283331000923 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1283331000924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331000925 S-adenosylmethionine binding site [chemical binding]; other site 1283331000926 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1283331000927 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283331000928 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1283331000929 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1283331000930 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283331000931 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1283331000932 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1283331000933 ATP binding site [chemical binding]; other site 1283331000934 Mg++ binding site [ion binding]; other site 1283331000935 motif III; other site 1283331000936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331000937 nucleotide binding region [chemical binding]; other site 1283331000938 ATP-binding site [chemical binding]; other site 1283331000939 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1283331000940 FAD binding site [chemical binding]; other site 1283331000941 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1283331000942 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1283331000943 homotetramer interface [polypeptide binding]; other site 1283331000944 ligand binding site [chemical binding]; other site 1283331000945 catalytic site [active] 1283331000946 NAD binding site [chemical binding]; other site 1283331000947 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1283331000948 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1283331000949 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1283331000950 nucleotide binding pocket [chemical binding]; other site 1283331000951 K-X-D-G motif; other site 1283331000952 catalytic site [active] 1283331000953 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1283331000954 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1283331000955 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1283331000956 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1283331000957 non-specific DNA interactions [nucleotide binding]; other site 1283331000958 DNA binding site [nucleotide binding] 1283331000959 sequence specific DNA binding site [nucleotide binding]; other site 1283331000960 putative cAMP binding site [chemical binding]; other site 1283331000961 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1283331000962 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1283331000963 nucleotide binding site [chemical binding]; other site 1283331000964 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1283331000965 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1283331000966 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1283331000967 shikimate binding site; other site 1283331000968 NAD(P) binding site [chemical binding]; other site 1283331000969 DctM-like transporters; Region: DctM; pfam06808 1283331000970 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1283331000971 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1283331000972 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1283331000973 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1283331000974 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283331000975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331000976 active site 1283331000977 phosphorylation site [posttranslational modification] 1283331000978 intermolecular recognition site; other site 1283331000979 dimerization interface [polypeptide binding]; other site 1283331000980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331000981 Walker A motif; other site 1283331000982 ATP binding site [chemical binding]; other site 1283331000983 Walker B motif; other site 1283331000984 arginine finger; other site 1283331000985 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331000986 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1283331000987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331000988 dimer interface [polypeptide binding]; other site 1283331000989 phosphorylation site [posttranslational modification] 1283331000990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331000991 ATP binding site [chemical binding]; other site 1283331000992 Mg2+ binding site [ion binding]; other site 1283331000993 G-X-G motif; other site 1283331000994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331000995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331000996 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283331000997 dimerization interface [polypeptide binding]; other site 1283331000998 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283331000999 active site 1283331001000 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1283331001001 dimer interface [polypeptide binding]; other site 1283331001002 non-prolyl cis peptide bond; other site 1283331001003 insertion regions; other site 1283331001004 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1283331001005 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1283331001006 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1283331001007 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1283331001008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1283331001009 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331001010 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331001011 membrane-bound complex binding site; other site 1283331001012 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283331001013 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1283331001014 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1283331001015 phosphate binding site [ion binding]; other site 1283331001016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331001017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331001018 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331001019 putative effector binding pocket; other site 1283331001020 dimerization interface [polypeptide binding]; other site 1283331001021 Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526 1283331001022 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1283331001023 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1283331001024 [4Fe-4S] binding site [ion binding]; other site 1283331001025 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1283331001026 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1283331001027 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1283331001028 molybdopterin cofactor binding site; other site 1283331001029 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1283331001030 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1283331001031 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1283331001032 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1283331001033 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1283331001034 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1283331001035 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1283331001036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331001037 FeS/SAM binding site; other site 1283331001038 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1283331001039 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1283331001040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331001041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331001042 DNA binding residues [nucleotide binding] 1283331001043 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283331001044 FecR protein; Region: FecR; pfam04773 1283331001045 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 1283331001046 phasin family protein; Region: phasin; TIGR01841 1283331001047 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 1283331001048 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283331001049 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283331001050 HlyD family secretion protein; Region: HlyD; pfam00529 1283331001051 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283331001052 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331001053 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1283331001054 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1283331001055 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1283331001056 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1283331001057 Outer membrane efflux protein; Region: OEP; pfam02321 1283331001058 Outer membrane efflux protein; Region: OEP; pfam02321 1283331001059 transcriptional regulator; Provisional; Region: PRK10632 1283331001060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331001061 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331001062 putative effector binding pocket; other site 1283331001063 dimerization interface [polypeptide binding]; other site 1283331001064 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1283331001065 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283331001066 ligand binding site [chemical binding]; other site 1283331001067 Restriction endonuclease; Region: Mrr_cat; pfam04471 1283331001068 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1283331001069 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 1283331001070 putative active site [active] 1283331001071 putative metal binding site [ion binding]; other site 1283331001072 malate:quinone oxidoreductase; Validated; Region: PRK05257 1283331001073 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1283331001074 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1283331001075 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1283331001076 glucokinase; Provisional; Region: glk; PRK00292 1283331001077 glucokinase, proteobacterial type; Region: glk; TIGR00749 1283331001078 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1283331001079 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283331001080 putative metal binding site [ion binding]; other site 1283331001081 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1283331001082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331001083 putative substrate translocation pore; other site 1283331001084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331001085 salt bridge; other site 1283331001086 non-specific DNA binding site [nucleotide binding]; other site 1283331001087 sequence-specific DNA binding site [nucleotide binding]; other site 1283331001088 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1283331001089 Helix-turn-helix domain; Region: HTH_39; pfam14090 1283331001090 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1283331001091 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1283331001092 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1283331001093 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1283331001094 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1283331001095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1283331001096 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1283331001097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1283331001098 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1283331001099 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1283331001100 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1283331001101 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1283331001102 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1283331001103 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 1283331001104 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1283331001105 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1283331001106 ligand binding site [chemical binding]; other site 1283331001107 flexible hinge region; other site 1283331001108 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1283331001109 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1283331001110 FAD binding pocket [chemical binding]; other site 1283331001111 FAD binding motif [chemical binding]; other site 1283331001112 phosphate binding motif [ion binding]; other site 1283331001113 beta-alpha-beta structure motif; other site 1283331001114 NAD binding pocket [chemical binding]; other site 1283331001115 Iron coordination center [ion binding]; other site 1283331001116 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1283331001117 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1283331001118 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 1283331001119 nickel binding site [ion binding]; other site 1283331001120 hypothetical protein; Provisional; Region: PRK10649 1283331001121 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1283331001122 Sulfatase; Region: Sulfatase; pfam00884 1283331001123 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1283331001124 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1283331001125 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1283331001126 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 1283331001127 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 1283331001128 P-loop; other site 1283331001129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1283331001130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283331001131 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 1283331001132 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 1283331001133 ACS interaction site; other site 1283331001134 CODH interaction site; other site 1283331001135 cubane metal cluster (B-cluster) [ion binding]; other site 1283331001136 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 1283331001137 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1283331001138 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1283331001139 oxidative damage protection protein; Provisional; Region: PRK05408 1283331001140 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1283331001141 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1283331001142 minor groove reading motif; other site 1283331001143 helix-hairpin-helix signature motif; other site 1283331001144 substrate binding pocket [chemical binding]; other site 1283331001145 active site 1283331001146 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1283331001147 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1283331001148 DNA binding and oxoG recognition site [nucleotide binding] 1283331001149 AsmA family; Region: AsmA; pfam05170 1283331001150 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1283331001151 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1283331001152 hypothetical protein; Validated; Region: PRK06201 1283331001153 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1283331001154 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1283331001155 putative active site pocket [active] 1283331001156 4-fold oligomerization interface [polypeptide binding]; other site 1283331001157 metal binding residues [ion binding]; metal-binding site 1283331001158 3-fold/trimer interface [polypeptide binding]; other site 1283331001159 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1283331001160 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1283331001161 putative active site [active] 1283331001162 oxyanion strand; other site 1283331001163 catalytic triad [active] 1283331001164 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1283331001165 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1283331001166 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1283331001167 catalytic residues [active] 1283331001168 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1283331001169 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1283331001170 substrate binding site [chemical binding]; other site 1283331001171 glutamase interaction surface [polypeptide binding]; other site 1283331001172 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1283331001173 C-terminal peptidase (prc); Region: prc; TIGR00225 1283331001174 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1283331001175 protein binding site [polypeptide binding]; other site 1283331001176 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1283331001177 Catalytic dyad [active] 1283331001178 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 1283331001179 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1283331001180 Peptidase family M23; Region: Peptidase_M23; pfam01551 1283331001181 phosphoglyceromutase; Provisional; Region: PRK05434 1283331001182 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1283331001183 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1283331001184 active site residue [active] 1283331001185 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1283331001186 GSH binding site [chemical binding]; other site 1283331001187 catalytic residues [active] 1283331001188 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1283331001189 SecA binding site; other site 1283331001190 Preprotein binding site; other site 1283331001191 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1283331001192 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1283331001193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331001194 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283331001195 dimerization interface [polypeptide binding]; other site 1283331001196 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 1283331001197 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1283331001198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283331001199 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1283331001200 Protein of unknown function (DUF330); Region: DUF330; cl01135 1283331001201 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1283331001202 mce related protein; Region: MCE; pfam02470 1283331001203 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1283331001204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331001205 Walker A/P-loop; other site 1283331001206 ATP binding site [chemical binding]; other site 1283331001207 Q-loop/lid; other site 1283331001208 ABC transporter signature motif; other site 1283331001209 Walker B; other site 1283331001210 D-loop; other site 1283331001211 H-loop/switch region; other site 1283331001212 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1283331001213 Permease; Region: Permease; pfam02405 1283331001214 Protein of unknown function, DUF480; Region: DUF480; pfam04337 1283331001215 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1283331001216 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1283331001217 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1283331001218 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1283331001219 Walker A motif; other site 1283331001220 ATP binding site [chemical binding]; other site 1283331001221 Walker B motif; other site 1283331001222 Protein of unknown function (DUF502); Region: DUF502; cl01107 1283331001223 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1283331001224 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1283331001225 putative active site [active] 1283331001226 putative metal binding residues [ion binding]; other site 1283331001227 signature motif; other site 1283331001228 putative triphosphate binding site [ion binding]; other site 1283331001229 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1283331001230 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1283331001231 Cl binding site [ion binding]; other site 1283331001232 oligomer interface [polypeptide binding]; other site 1283331001233 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1283331001234 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1283331001235 acetylornithine deacetylase; Provisional; Region: PRK05111 1283331001236 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1283331001237 metal binding site [ion binding]; metal-binding site 1283331001238 putative dimer interface [polypeptide binding]; other site 1283331001239 N-acetylglutamate synthase; Validated; Region: PRK05279 1283331001240 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1283331001241 putative feedback inhibition sensing region; other site 1283331001242 putative nucleotide binding site [chemical binding]; other site 1283331001243 putative substrate binding site [chemical binding]; other site 1283331001244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1283331001245 Coenzyme A binding pocket [chemical binding]; other site 1283331001246 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1283331001247 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283331001248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331001249 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331001250 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331001251 metal binding site [ion binding]; metal-binding site 1283331001252 active site 1283331001253 I-site; other site 1283331001254 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1283331001255 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1283331001256 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331001257 Phytase; Region: Phytase; cl17685 1283331001258 Phytase; Region: Phytase; cl17685 1283331001259 TolQ protein; Region: tolQ; TIGR02796 1283331001260 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283331001261 TolR protein; Region: tolR; TIGR02801 1283331001262 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283331001263 glutamate--cysteine ligase; Provisional; Region: PRK02107 1283331001264 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1283331001265 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1283331001266 CoenzymeA binding site [chemical binding]; other site 1283331001267 subunit interaction site [polypeptide binding]; other site 1283331001268 PHB binding site; other site 1283331001269 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1283331001270 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1283331001271 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1283331001272 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1283331001273 RNA binding site [nucleotide binding]; other site 1283331001274 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1283331001275 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 1283331001276 TPR repeat; Region: TPR_11; pfam13414 1283331001277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283331001278 TPR motif; other site 1283331001279 binding surface 1283331001280 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1283331001281 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1283331001282 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1283331001283 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1283331001284 DXD motif; other site 1283331001285 PilZ domain; Region: PilZ; pfam07238 1283331001286 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 1283331001287 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 1283331001288 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283331001289 P-loop; other site 1283331001290 Magnesium ion binding site [ion binding]; other site 1283331001291 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1283331001292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331001293 active site 1283331001294 phosphorylation site [posttranslational modification] 1283331001295 intermolecular recognition site; other site 1283331001296 dimerization interface [polypeptide binding]; other site 1283331001297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331001298 DNA binding site [nucleotide binding] 1283331001299 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1283331001300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331001301 dimerization interface [polypeptide binding]; other site 1283331001302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331001303 ATP binding site [chemical binding]; other site 1283331001304 Mg2+ binding site [ion binding]; other site 1283331001305 G-X-G motif; other site 1283331001306 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1283331001307 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1283331001308 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1283331001309 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1283331001310 RNA binding surface [nucleotide binding]; other site 1283331001311 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331001312 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1283331001313 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1283331001314 dimer interface [polypeptide binding]; other site 1283331001315 NADP binding site [chemical binding]; other site 1283331001316 catalytic residues [active] 1283331001317 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1283331001318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283331001319 DNA-binding site [nucleotide binding]; DNA binding site 1283331001320 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1283331001321 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1283331001322 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1283331001323 putative active site [active] 1283331001324 catalytic residue [active] 1283331001325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331001326 D-galactonate transporter; Region: 2A0114; TIGR00893 1283331001327 putative substrate translocation pore; other site 1283331001328 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1283331001329 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1283331001330 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1283331001331 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1283331001332 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1283331001333 putative ligand binding site [chemical binding]; other site 1283331001334 NAD binding site [chemical binding]; other site 1283331001335 catalytic site [active] 1283331001336 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1283331001337 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1283331001338 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1283331001339 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1283331001340 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1283331001341 putative active site [active] 1283331001342 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 1283331001343 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283331001344 DXD motif; other site 1283331001345 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1283331001346 active site 1283331001347 O-Antigen ligase; Region: Wzy_C; pfam04932 1283331001348 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1283331001349 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283331001350 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1283331001351 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1283331001352 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1283331001353 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1283331001354 SLBB domain; Region: SLBB; pfam10531 1283331001355 AAA domain; Region: AAA_31; pfam13614 1283331001356 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1283331001357 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1283331001358 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1283331001359 putative NAD(P) binding site [chemical binding]; other site 1283331001360 active site 1283331001361 putative substrate binding site [chemical binding]; other site 1283331001362 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1283331001363 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1283331001364 dimerization interface [polypeptide binding]; other site 1283331001365 domain crossover interface; other site 1283331001366 redox-dependent activation switch; other site 1283331001367 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1283331001368 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1283331001369 active site 1283331001370 substrate-binding site [chemical binding]; other site 1283331001371 metal-binding site [ion binding] 1283331001372 ATP binding site [chemical binding]; other site 1283331001373 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1283331001374 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1283331001375 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1283331001376 putative active site [active] 1283331001377 catalytic site [active] 1283331001378 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1283331001379 putative active site [active] 1283331001380 catalytic site [active] 1283331001381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1283331001382 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1283331001383 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1283331001384 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1283331001385 dimer interface [polypeptide binding]; other site 1283331001386 ADP-ribose binding site [chemical binding]; other site 1283331001387 active site 1283331001388 nudix motif; other site 1283331001389 metal binding site [ion binding]; metal-binding site 1283331001390 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1283331001391 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1283331001392 active site 1283331001393 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1283331001394 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1283331001395 active site 1283331001396 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1283331001397 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1283331001398 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1283331001399 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1283331001400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331001401 putative DNA binding site [nucleotide binding]; other site 1283331001402 putative Zn2+ binding site [ion binding]; other site 1283331001403 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1283331001404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331001405 S-adenosylmethionine binding site [chemical binding]; other site 1283331001406 transketolase; Reviewed; Region: PRK12753 1283331001407 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1283331001408 TPP-binding site [chemical binding]; other site 1283331001409 dimer interface [polypeptide binding]; other site 1283331001410 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1283331001411 PYR/PP interface [polypeptide binding]; other site 1283331001412 dimer interface [polypeptide binding]; other site 1283331001413 TPP binding site [chemical binding]; other site 1283331001414 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283331001415 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 1283331001416 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1283331001417 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1283331001418 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1283331001419 Phosphoglycerate kinase; Region: PGK; pfam00162 1283331001420 substrate binding site [chemical binding]; other site 1283331001421 hinge regions; other site 1283331001422 ADP binding site [chemical binding]; other site 1283331001423 catalytic site [active] 1283331001424 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1283331001425 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1283331001426 intersubunit interface [polypeptide binding]; other site 1283331001427 active site 1283331001428 zinc binding site [ion binding]; other site 1283331001429 Na+ binding site [ion binding]; other site 1283331001430 Domain of unknown function (DUF336); Region: DUF336; cl01249 1283331001431 putative oxidoreductase; Provisional; Region: PRK11579 1283331001432 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283331001433 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283331001434 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1283331001435 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1283331001436 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1283331001437 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1283331001438 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1283331001439 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1283331001440 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1283331001441 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1283331001442 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1283331001443 Cytochrome c; Region: Cytochrom_C; pfam00034 1283331001444 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1283331001445 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1283331001446 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1283331001447 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1283331001448 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1283331001449 active site residues [active] 1283331001450 dimer interface [polypeptide binding]; other site 1283331001451 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1283331001452 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1283331001453 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1283331001454 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1283331001455 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1283331001456 hexamer interface [polypeptide binding]; other site 1283331001457 ligand binding site [chemical binding]; other site 1283331001458 putative active site [active] 1283331001459 NAD(P) binding site [chemical binding]; other site 1283331001460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283331001461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331001462 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 1283331001463 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1283331001464 putative C-terminal domain interface [polypeptide binding]; other site 1283331001465 putative GSH binding site (G-site) [chemical binding]; other site 1283331001466 putative dimer interface [polypeptide binding]; other site 1283331001467 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1283331001468 N-terminal domain interface [polypeptide binding]; other site 1283331001469 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1283331001470 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1283331001471 C-terminal domain interface [polypeptide binding]; other site 1283331001472 GSH binding site (G-site) [chemical binding]; other site 1283331001473 dimer interface [polypeptide binding]; other site 1283331001474 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1283331001475 N-terminal domain interface [polypeptide binding]; other site 1283331001476 putative dimer interface [polypeptide binding]; other site 1283331001477 active site 1283331001478 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1283331001479 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1283331001480 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331001481 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331001482 metal binding site [ion binding]; metal-binding site 1283331001483 active site 1283331001484 I-site; other site 1283331001485 putative transporter; Provisional; Region: PRK10504 1283331001486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331001487 putative substrate translocation pore; other site 1283331001488 TraX protein; Region: TraX; pfam05857 1283331001489 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1283331001490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331001491 putative substrate translocation pore; other site 1283331001492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1283331001493 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1283331001494 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1283331001495 putative acyl-acceptor binding pocket; other site 1283331001496 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1283331001497 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1283331001498 dimer interface [polypeptide binding]; other site 1283331001499 active site 1283331001500 heme binding site [chemical binding]; other site 1283331001501 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1283331001502 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1283331001503 active site 1283331001504 catalytic site [active] 1283331001505 substrate binding site [chemical binding]; other site 1283331001506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1283331001507 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1283331001508 Probable transposase; Region: OrfB_IS605; pfam01385 1283331001509 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1283331001510 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1283331001511 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1283331001512 ligand binding site [chemical binding]; other site 1283331001513 flexible hinge region; other site 1283331001514 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1283331001515 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1283331001516 metal binding triad; other site 1283331001517 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1283331001518 active site 1283331001519 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1283331001520 ACT domain; Region: ACT_6; pfam13740 1283331001521 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1283331001522 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1283331001523 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1283331001524 dimerization domain [polypeptide binding]; other site 1283331001525 dimer interface [polypeptide binding]; other site 1283331001526 catalytic residues [active] 1283331001527 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1283331001528 EamA-like transporter family; Region: EamA; pfam00892 1283331001529 serine/threonine protein kinase; Provisional; Region: PRK11768 1283331001530 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1283331001531 DNA utilization protein GntX; Provisional; Region: PRK11595 1283331001532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331001533 active site 1283331001534 biotin synthase; Provisional; Region: PRK15108 1283331001535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331001536 FeS/SAM binding site; other site 1283331001537 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1283331001538 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1283331001539 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1283331001540 substrate-cofactor binding pocket; other site 1283331001541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331001542 catalytic residue [active] 1283331001543 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1283331001544 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1283331001545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331001546 S-adenosylmethionine binding site [chemical binding]; other site 1283331001547 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1283331001548 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1283331001549 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1283331001550 putative acyl-acceptor binding pocket; other site 1283331001551 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1283331001552 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1283331001553 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1283331001554 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1283331001555 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1283331001556 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1283331001557 pantothenate kinase; Reviewed; Region: PRK13322 1283331001558 elongation factor Tu; Reviewed; Region: PRK00049 1283331001559 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1283331001560 G1 box; other site 1283331001561 GEF interaction site [polypeptide binding]; other site 1283331001562 GTP/Mg2+ binding site [chemical binding]; other site 1283331001563 Switch I region; other site 1283331001564 G2 box; other site 1283331001565 G3 box; other site 1283331001566 Switch II region; other site 1283331001567 G4 box; other site 1283331001568 G5 box; other site 1283331001569 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1283331001570 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1283331001571 Antibiotic Binding Site [chemical binding]; other site 1283331001572 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1283331001573 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 1283331001574 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1283331001575 putative homodimer interface [polypeptide binding]; other site 1283331001576 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1283331001577 heterodimer interface [polypeptide binding]; other site 1283331001578 homodimer interface [polypeptide binding]; other site 1283331001579 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1283331001580 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1283331001581 23S rRNA interface [nucleotide binding]; other site 1283331001582 L7/L12 interface [polypeptide binding]; other site 1283331001583 putative thiostrepton binding site; other site 1283331001584 L25 interface [polypeptide binding]; other site 1283331001585 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1283331001586 mRNA/rRNA interface [nucleotide binding]; other site 1283331001587 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1283331001588 23S rRNA interface [nucleotide binding]; other site 1283331001589 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1283331001590 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1283331001591 core dimer interface [polypeptide binding]; other site 1283331001592 peripheral dimer interface [polypeptide binding]; other site 1283331001593 L10 interface [polypeptide binding]; other site 1283331001594 L11 interface [polypeptide binding]; other site 1283331001595 putative EF-Tu interaction site [polypeptide binding]; other site 1283331001596 putative EF-G interaction site [polypeptide binding]; other site 1283331001597 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1283331001598 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1283331001599 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1283331001600 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1283331001601 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1283331001602 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1283331001603 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1283331001604 RPB3 interaction site [polypeptide binding]; other site 1283331001605 RPB1 interaction site [polypeptide binding]; other site 1283331001606 RPB11 interaction site [polypeptide binding]; other site 1283331001607 RPB10 interaction site [polypeptide binding]; other site 1283331001608 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1283331001609 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1283331001610 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1283331001611 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1283331001612 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1283331001613 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1283331001614 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1283331001615 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1283331001616 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1283331001617 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1283331001618 DNA binding site [nucleotide binding] 1283331001619 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1283331001620 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1283331001621 S17 interaction site [polypeptide binding]; other site 1283331001622 S8 interaction site; other site 1283331001623 16S rRNA interaction site [nucleotide binding]; other site 1283331001624 streptomycin interaction site [chemical binding]; other site 1283331001625 23S rRNA interaction site [nucleotide binding]; other site 1283331001626 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1283331001627 30S ribosomal protein S7; Validated; Region: PRK05302 1283331001628 elongation factor G; Reviewed; Region: PRK00007 1283331001629 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1283331001630 Switch I region; other site 1283331001631 G2 box; other site 1283331001632 putative GEF interaction site [polypeptide binding]; other site 1283331001633 G3 box; other site 1283331001634 Switch II region; other site 1283331001635 GTP/Mg2+ binding site [chemical binding]; other site 1283331001636 G4 box; other site 1283331001637 G5 box; other site 1283331001638 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1283331001639 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1283331001640 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1283331001641 elongation factor Tu; Reviewed; Region: PRK00049 1283331001642 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1283331001643 G1 box; other site 1283331001644 GEF interaction site [polypeptide binding]; other site 1283331001645 GTP/Mg2+ binding site [chemical binding]; other site 1283331001646 Switch I region; other site 1283331001647 G2 box; other site 1283331001648 G3 box; other site 1283331001649 Switch II region; other site 1283331001650 G4 box; other site 1283331001651 G5 box; other site 1283331001652 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1283331001653 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1283331001654 Antibiotic Binding Site [chemical binding]; other site 1283331001655 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1283331001656 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1283331001657 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1283331001658 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1283331001659 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1283331001660 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1283331001661 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1283331001662 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1283331001663 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1283331001664 protein-rRNA interface [nucleotide binding]; other site 1283331001665 putative translocon binding site; other site 1283331001666 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1283331001667 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1283331001668 G-X-X-G motif; other site 1283331001669 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1283331001670 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1283331001671 23S rRNA interface [nucleotide binding]; other site 1283331001672 5S rRNA interface [nucleotide binding]; other site 1283331001673 putative antibiotic binding site [chemical binding]; other site 1283331001674 L25 interface [polypeptide binding]; other site 1283331001675 L27 interface [polypeptide binding]; other site 1283331001676 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1283331001677 23S rRNA interface [nucleotide binding]; other site 1283331001678 putative translocon interaction site; other site 1283331001679 signal recognition particle (SRP54) interaction site; other site 1283331001680 L23 interface [polypeptide binding]; other site 1283331001681 trigger factor interaction site; other site 1283331001682 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1283331001683 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1283331001684 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1283331001685 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1283331001686 RNA binding site [nucleotide binding]; other site 1283331001687 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1283331001688 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1283331001689 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1283331001690 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1283331001691 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1283331001692 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1283331001693 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1283331001694 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1283331001695 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1283331001696 5S rRNA interface [nucleotide binding]; other site 1283331001697 23S rRNA interface [nucleotide binding]; other site 1283331001698 L5 interface [polypeptide binding]; other site 1283331001699 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1283331001700 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1283331001701 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1283331001702 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1283331001703 23S rRNA binding site [nucleotide binding]; other site 1283331001704 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1283331001705 preprotein translocase, SecY subunit; Region: 3a0501s007; TIGR00967 1283331001706 SecY translocase; Region: SecY; pfam00344 1283331001707 Ribosomal protein L36 [Translation, ribosomal structure and biogenesis]; Region: RpmJ; COG0257 1283331001708 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1283331001709 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1283331001710 30S ribosomal protein S11; Validated; Region: PRK05309 1283331001711 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1283331001712 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1283331001713 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1283331001714 RNA binding surface [nucleotide binding]; other site 1283331001715 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1283331001716 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1283331001717 alphaNTD homodimer interface [polypeptide binding]; other site 1283331001718 alphaNTD - beta interaction site [polypeptide binding]; other site 1283331001719 alphaNTD - beta' interaction site [polypeptide binding]; other site 1283331001720 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1283331001721 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1283331001722 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1283331001723 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1283331001724 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1283331001725 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1283331001726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331001727 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283331001728 putative substrate translocation pore; other site 1283331001729 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1283331001730 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1283331001731 dimer interface [polypeptide binding]; other site 1283331001732 ssDNA binding site [nucleotide binding]; other site 1283331001733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1283331001734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331001735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331001736 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1283331001737 putative effector binding pocket; other site 1283331001738 putative dimerization interface [polypeptide binding]; other site 1283331001739 short chain dehydrogenase; Provisional; Region: PRK12937 1283331001740 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1283331001741 NADP binding site [chemical binding]; other site 1283331001742 homodimer interface [polypeptide binding]; other site 1283331001743 active site 1283331001744 substrate binding site [chemical binding]; other site 1283331001745 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1283331001746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331001747 NAD(P) binding site [chemical binding]; other site 1283331001748 active site 1283331001749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331001750 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1283331001751 NAD(P) binding site [chemical binding]; other site 1283331001752 active site 1283331001753 OmpW family; Region: OmpW; cl17427 1283331001754 OmpW family; Region: OmpW; cl17427 1283331001755 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1283331001756 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1283331001757 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1283331001758 FtsX-like permease family; Region: FtsX; pfam02687 1283331001759 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1283331001760 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1283331001761 Walker A/P-loop; other site 1283331001762 ATP binding site [chemical binding]; other site 1283331001763 Q-loop/lid; other site 1283331001764 ABC transporter signature motif; other site 1283331001765 Walker B; other site 1283331001766 D-loop; other site 1283331001767 H-loop/switch region; other site 1283331001768 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 1283331001769 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1283331001770 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1283331001771 Predicted methyltransferase [General function prediction only]; Region: COG3897 1283331001772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1283331001773 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1283331001774 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1283331001775 ATP cone domain; Region: ATP-cone; pfam03477 1283331001776 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1283331001777 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1283331001778 catalytic motif [active] 1283331001779 Zn binding site [ion binding]; other site 1283331001780 RibD C-terminal domain; Region: RibD_C; cl17279 1283331001781 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1283331001782 Lumazine binding domain; Region: Lum_binding; pfam00677 1283331001783 Lumazine binding domain; Region: Lum_binding; pfam00677 1283331001784 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1283331001785 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1283331001786 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1283331001787 dimerization interface [polypeptide binding]; other site 1283331001788 active site 1283331001789 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1283331001790 homopentamer interface [polypeptide binding]; other site 1283331001791 active site 1283331001792 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1283331001793 thiamine monophosphate kinase; Provisional; Region: PRK05731 1283331001794 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1283331001795 ATP binding site [chemical binding]; other site 1283331001796 dimerization interface [polypeptide binding]; other site 1283331001797 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1283331001798 tetramer interfaces [polypeptide binding]; other site 1283331001799 binuclear metal-binding site [ion binding]; other site 1283331001800 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331001801 membrane-bound complex binding site; other site 1283331001802 hinge residues; other site 1283331001803 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1283331001804 dimerization interface [polypeptide binding]; other site 1283331001805 active site 1283331001806 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1283331001807 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1283331001808 cobalamin binding residues [chemical binding]; other site 1283331001809 putative BtuC binding residues; other site 1283331001810 dimer interface [polypeptide binding]; other site 1283331001811 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1283331001812 putative chaperone; Provisional; Region: PRK11678 1283331001813 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1283331001814 nucleotide binding site [chemical binding]; other site 1283331001815 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1283331001816 SBD interface [polypeptide binding]; other site 1283331001817 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1283331001818 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1283331001819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331001820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331001821 dimer interface [polypeptide binding]; other site 1283331001822 phosphorylation site [posttranslational modification] 1283331001823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331001824 ATP binding site [chemical binding]; other site 1283331001825 Mg2+ binding site [ion binding]; other site 1283331001826 G-X-G motif; other site 1283331001827 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1283331001828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331001829 active site 1283331001830 phosphorylation site [posttranslational modification] 1283331001831 intermolecular recognition site; other site 1283331001832 dimerization interface [polypeptide binding]; other site 1283331001833 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331001834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331001835 active site 1283331001836 phosphorylation site [posttranslational modification] 1283331001837 intermolecular recognition site; other site 1283331001838 dimerization interface [polypeptide binding]; other site 1283331001839 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1283331001840 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1283331001841 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1283331001842 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1283331001843 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1283331001844 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1283331001845 purine monophosphate binding site [chemical binding]; other site 1283331001846 dimer interface [polypeptide binding]; other site 1283331001847 putative catalytic residues [active] 1283331001848 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1283331001849 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1283331001850 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1283331001851 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1283331001852 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1283331001853 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1283331001854 FMN binding site [chemical binding]; other site 1283331001855 active site 1283331001856 catalytic residues [active] 1283331001857 substrate binding site [chemical binding]; other site 1283331001858 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1283331001859 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1283331001860 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1283331001861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331001862 S-adenosylmethionine binding site [chemical binding]; other site 1283331001863 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1283331001864 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1283331001865 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1283331001866 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1283331001867 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1283331001868 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1283331001869 carboxyltransferase (CT) interaction site; other site 1283331001870 biotinylation site [posttranslational modification]; other site 1283331001871 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1283331001872 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1283331001873 active site 1283331001874 trimer interface [polypeptide binding]; other site 1283331001875 dimer interface [polypeptide binding]; other site 1283331001876 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1283331001877 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1283331001878 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1283331001879 DsbD alpha interface [polypeptide binding]; other site 1283331001880 catalytic residues [active] 1283331001881 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 1283331001882 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1283331001883 nudix motif; other site 1283331001884 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1283331001885 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1283331001886 putative ligand binding site [chemical binding]; other site 1283331001887 putative NAD binding site [chemical binding]; other site 1283331001888 catalytic site [active] 1283331001889 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 1283331001890 Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Region: NT_PAP_TUTase; cd05402 1283331001891 active site 1283331001892 metal binding triad [ion binding]; metal-binding site 1283331001893 translation initiation factor Sui1; Validated; Region: PRK06824 1283331001894 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1283331001895 putative rRNA binding site [nucleotide binding]; other site 1283331001896 arginine decarboxylase; Provisional; Region: PRK05354 1283331001897 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1283331001898 dimer interface [polypeptide binding]; other site 1283331001899 active site 1283331001900 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283331001901 catalytic residues [active] 1283331001902 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1283331001903 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1283331001904 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1283331001905 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331001906 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331001907 Ligand Binding Site [chemical binding]; other site 1283331001908 SdiA-regulated; Region: SdiA-regulated; pfam06977 1283331001909 SdiA-regulated; Region: SdiA-regulated; cd09971 1283331001910 putative active site [active] 1283331001911 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1283331001912 amphipathic channel; other site 1283331001913 Asn-Pro-Ala signature motifs; other site 1283331001914 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1283331001915 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1283331001916 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1283331001917 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1283331001918 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1283331001919 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1283331001920 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1283331001921 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1283331001922 nucleophile elbow; other site 1283331001923 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1283331001924 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1283331001925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331001926 S-adenosylmethionine binding site [chemical binding]; other site 1283331001927 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1283331001928 homodimer interface [polypeptide binding]; other site 1283331001929 chemical substrate binding site [chemical binding]; other site 1283331001930 oligomer interface [polypeptide binding]; other site 1283331001931 metal binding site [ion binding]; metal-binding site 1283331001932 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 1283331001933 homodimer interface [polypeptide binding]; other site 1283331001934 active site 1283331001935 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1283331001936 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1283331001937 Walker A/P-loop; other site 1283331001938 ATP binding site [chemical binding]; other site 1283331001939 Q-loop/lid; other site 1283331001940 ABC transporter signature motif; other site 1283331001941 Walker B; other site 1283331001942 D-loop; other site 1283331001943 H-loop/switch region; other site 1283331001944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331001945 dimer interface [polypeptide binding]; other site 1283331001946 conserved gate region; other site 1283331001947 putative PBP binding loops; other site 1283331001948 ABC-ATPase subunit interface; other site 1283331001949 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1283331001950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331001951 dimer interface [polypeptide binding]; other site 1283331001952 conserved gate region; other site 1283331001953 putative PBP binding loops; other site 1283331001954 ABC-ATPase subunit interface; other site 1283331001955 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1283331001956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331001957 substrate binding pocket [chemical binding]; other site 1283331001958 membrane-bound complex binding site; other site 1283331001959 hinge residues; other site 1283331001960 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1283331001961 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1283331001962 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1283331001963 Moco binding site; other site 1283331001964 metal coordination site [ion binding]; other site 1283331001965 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1283331001966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331001967 NAD(P) binding site [chemical binding]; other site 1283331001968 active site 1283331001969 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1283331001970 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283331001971 dimer interface [polypeptide binding]; other site 1283331001972 active site 1283331001973 General stress protein [General function prediction only]; Region: GsiB; COG3729 1283331001974 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 1283331001975 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1283331001976 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1283331001977 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1283331001978 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1283331001979 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1283331001980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331001981 motif II; other site 1283331001982 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1283331001983 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 1283331001984 tetramer interface [polypeptide binding]; other site 1283331001985 catalytic Zn binding site [ion binding]; other site 1283331001986 NADP binding site [chemical binding]; other site 1283331001987 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1283331001988 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1283331001989 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1283331001990 active site residue [active] 1283331001991 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1283331001992 active site residue [active] 1283331001993 GTPase RsgA; Reviewed; Region: PRK12288 1283331001994 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1283331001995 RNA binding site [nucleotide binding]; other site 1283331001996 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1283331001997 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1283331001998 GTP/Mg2+ binding site [chemical binding]; other site 1283331001999 G4 box; other site 1283331002000 G5 box; other site 1283331002001 G1 box; other site 1283331002002 Switch I region; other site 1283331002003 G2 box; other site 1283331002004 G3 box; other site 1283331002005 Switch II region; other site 1283331002006 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1283331002007 catalytic site [active] 1283331002008 putative active site [active] 1283331002009 putative substrate binding site [chemical binding]; other site 1283331002010 dimer interface [polypeptide binding]; other site 1283331002011 epoxyqueuosine reductase; Region: TIGR00276 1283331002012 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1283331002013 putative carbohydrate kinase; Provisional; Region: PRK10565 1283331002014 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1283331002015 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1283331002016 putative substrate binding site [chemical binding]; other site 1283331002017 putative ATP binding site [chemical binding]; other site 1283331002018 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1283331002019 AMIN domain; Region: AMIN; pfam11741 1283331002020 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1283331002021 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1283331002022 active site 1283331002023 metal binding site [ion binding]; metal-binding site 1283331002024 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1283331002025 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1283331002026 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1283331002027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331002028 ATP binding site [chemical binding]; other site 1283331002029 Mg2+ binding site [ion binding]; other site 1283331002030 G-X-G motif; other site 1283331002031 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1283331002032 ATP binding site [chemical binding]; other site 1283331002033 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1283331002034 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1283331002035 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1283331002036 bacterial Hfq-like; Region: Hfq; cd01716 1283331002037 hexamer interface [polypeptide binding]; other site 1283331002038 Sm1 motif; other site 1283331002039 RNA binding site [nucleotide binding]; other site 1283331002040 Sm2 motif; other site 1283331002041 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1283331002042 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1283331002043 HflX GTPase family; Region: HflX; cd01878 1283331002044 G1 box; other site 1283331002045 GTP/Mg2+ binding site [chemical binding]; other site 1283331002046 Switch I region; other site 1283331002047 G2 box; other site 1283331002048 G3 box; other site 1283331002049 Switch II region; other site 1283331002050 G4 box; other site 1283331002051 G5 box; other site 1283331002052 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1283331002053 HflK protein; Region: hflK; TIGR01933 1283331002054 HflC protein; Region: hflC; TIGR01932 1283331002055 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1283331002056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1283331002057 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1283331002058 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1283331002059 dimer interface [polypeptide binding]; other site 1283331002060 motif 1; other site 1283331002061 active site 1283331002062 motif 2; other site 1283331002063 motif 3; other site 1283331002064 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1283331002065 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1283331002066 GDP-binding site [chemical binding]; other site 1283331002067 ACT binding site; other site 1283331002068 IMP binding site; other site 1283331002069 ribonuclease R; Region: RNase_R; TIGR02063 1283331002070 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1283331002071 RNB domain; Region: RNB; pfam00773 1283331002072 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1283331002073 RNA binding site [nucleotide binding]; other site 1283331002074 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1283331002075 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1283331002076 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1283331002077 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1283331002078 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1283331002079 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1283331002080 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1283331002081 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1283331002082 replicative DNA helicase; Provisional; Region: PRK05748 1283331002083 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1283331002084 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1283331002085 Walker A motif; other site 1283331002086 ATP binding site [chemical binding]; other site 1283331002087 Walker B motif; other site 1283331002088 DNA binding loops [nucleotide binding] 1283331002089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283331002090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331002091 hypothetical protein; Provisional; Region: PRK01254 1283331002092 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1283331002093 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1283331002094 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1283331002095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331002096 S-adenosylmethionine binding site [chemical binding]; other site 1283331002097 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1283331002098 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1283331002099 FAD binding pocket [chemical binding]; other site 1283331002100 FAD binding motif [chemical binding]; other site 1283331002101 phosphate binding motif [ion binding]; other site 1283331002102 beta-alpha-beta structure motif; other site 1283331002103 NAD binding pocket [chemical binding]; other site 1283331002104 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1283331002105 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1283331002106 active site 1283331002107 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1283331002108 catalytic triad [active] 1283331002109 dimer interface [polypeptide binding]; other site 1283331002110 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1283331002111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331002112 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1283331002113 Predicted metalloprotease [General function prediction only]; Region: COG2321 1283331002114 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1283331002115 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1283331002116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331002117 S-adenosylmethionine binding site [chemical binding]; other site 1283331002118 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1283331002119 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1283331002120 AAA domain; Region: AAA_18; pfam13238 1283331002121 active site 1283331002122 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1283331002123 catalytic triad [active] 1283331002124 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1283331002125 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331002126 N-terminal plug; other site 1283331002127 ligand-binding site [chemical binding]; other site 1283331002128 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1283331002129 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1283331002130 TPP-binding site; other site 1283331002131 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1283331002132 PYR/PP interface [polypeptide binding]; other site 1283331002133 dimer interface [polypeptide binding]; other site 1283331002134 TPP binding site [chemical binding]; other site 1283331002135 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283331002136 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1283331002137 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1283331002138 substrate binding pocket [chemical binding]; other site 1283331002139 chain length determination region; other site 1283331002140 substrate-Mg2+ binding site; other site 1283331002141 catalytic residues [active] 1283331002142 aspartate-rich region 1; other site 1283331002143 active site lid residues [active] 1283331002144 aspartate-rich region 2; other site 1283331002145 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1283331002146 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1283331002147 PAS domain S-box; Region: sensory_box; TIGR00229 1283331002148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331002149 putative active site [active] 1283331002150 heme pocket [chemical binding]; other site 1283331002151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331002152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331002153 metal binding site [ion binding]; metal-binding site 1283331002154 active site 1283331002155 I-site; other site 1283331002156 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283331002157 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1283331002158 dimer interface [polypeptide binding]; other site 1283331002159 substrate binding site [chemical binding]; other site 1283331002160 metal binding sites [ion binding]; metal-binding site 1283331002161 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1283331002162 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1283331002163 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1283331002164 NAD binding site [chemical binding]; other site 1283331002165 substrate binding site [chemical binding]; other site 1283331002166 catalytic Zn binding site [ion binding]; other site 1283331002167 tetramer interface [polypeptide binding]; other site 1283331002168 structural Zn binding site [ion binding]; other site 1283331002169 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1283331002170 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1283331002171 dimer interface [polypeptide binding]; other site 1283331002172 active site 1283331002173 metal binding site [ion binding]; metal-binding site 1283331002174 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1283331002175 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283331002176 NAD(P) binding site [chemical binding]; other site 1283331002177 catalytic residues [active] 1283331002178 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1283331002179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331002180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331002181 Walker A motif; other site 1283331002182 ATP binding site [chemical binding]; other site 1283331002183 Walker B motif; other site 1283331002184 arginine finger; other site 1283331002185 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331002186 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1283331002187 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1283331002188 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283331002189 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1283331002190 aromatic acid decarboxylase; Validated; Region: PRK05920 1283331002191 Flavoprotein; Region: Flavoprotein; pfam02441 1283331002192 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1283331002193 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283331002194 TolR protein; Region: tolR; TIGR02801 1283331002195 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1283331002196 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1283331002197 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283331002198 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283331002199 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283331002200 Walker A/P-loop; other site 1283331002201 ATP binding site [chemical binding]; other site 1283331002202 Q-loop/lid; other site 1283331002203 ABC transporter signature motif; other site 1283331002204 Walker B; other site 1283331002205 D-loop; other site 1283331002206 H-loop/switch region; other site 1283331002207 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283331002208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1283331002209 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283331002210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1283331002211 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331002212 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283331002213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331002214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331002215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283331002216 dimerization interface [polypeptide binding]; other site 1283331002217 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1283331002218 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331002219 N-terminal plug; other site 1283331002220 ligand-binding site [chemical binding]; other site 1283331002221 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283331002222 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283331002223 active site 1283331002224 iron coordination sites [ion binding]; other site 1283331002225 substrate binding pocket [chemical binding]; other site 1283331002226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283331002227 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1283331002228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331002229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331002230 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1283331002231 dimerization interface [polypeptide binding]; other site 1283331002232 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1283331002233 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331002234 N-terminal plug; other site 1283331002235 ligand-binding site [chemical binding]; other site 1283331002236 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1283331002237 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1283331002238 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1283331002239 Cache domain; Region: Cache_1; pfam02743 1283331002240 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331002241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331002242 metal binding site [ion binding]; metal-binding site 1283331002243 active site 1283331002244 I-site; other site 1283331002245 FtsH Extracellular; Region: FtsH_ext; pfam06480 1283331002246 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1283331002247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331002248 Walker A motif; other site 1283331002249 ATP binding site [chemical binding]; other site 1283331002250 Walker B motif; other site 1283331002251 arginine finger; other site 1283331002252 Peptidase family M41; Region: Peptidase_M41; pfam01434 1283331002253 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1283331002254 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1283331002255 NAD binding site [chemical binding]; other site 1283331002256 active site 1283331002257 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1283331002258 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1283331002259 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1283331002260 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1283331002261 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1283331002262 Ca binding site [ion binding]; other site 1283331002263 active site 1283331002264 catalytic site [active] 1283331002265 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1283331002266 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1283331002267 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1283331002268 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1283331002269 active site 1283331002270 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1283331002271 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1283331002272 putative catalytic cysteine [active] 1283331002273 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1283331002274 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1283331002275 active site 1283331002276 (T/H)XGH motif; other site 1283331002277 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1283331002278 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1283331002279 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1283331002280 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1283331002281 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1283331002282 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1283331002283 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1283331002284 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283331002285 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283331002286 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1283331002287 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1283331002288 Sporulation related domain; Region: SPOR; pfam05036 1283331002289 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1283331002290 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1283331002291 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1283331002292 hypothetical protein; Provisional; Region: PRK00341 1283331002293 lipoate-protein ligase B; Provisional; Region: PRK14342 1283331002294 lipoyl synthase; Provisional; Region: PRK05481 1283331002295 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331002296 FeS/SAM binding site; other site 1283331002297 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1283331002298 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1283331002299 PYR/PP interface [polypeptide binding]; other site 1283331002300 dimer interface [polypeptide binding]; other site 1283331002301 tetramer interface [polypeptide binding]; other site 1283331002302 TPP binding site [chemical binding]; other site 1283331002303 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1283331002304 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1283331002305 TPP-binding site [chemical binding]; other site 1283331002306 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1283331002307 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283331002308 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283331002309 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1283331002310 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1283331002311 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1283331002312 carboxyltransferase (CT) interaction site; other site 1283331002313 biotinylation site [posttranslational modification]; other site 1283331002314 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331002315 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1283331002316 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1283331002317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331002318 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446 1283331002319 dimerization interface [polypeptide binding]; other site 1283331002320 putative substrate binding pocket [chemical binding]; other site 1283331002321 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283331002322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283331002323 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1283331002324 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1283331002325 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1283331002326 putative alpha subunit interface [polypeptide binding]; other site 1283331002327 putative active site [active] 1283331002328 putative substrate binding site [chemical binding]; other site 1283331002329 Fe binding site [ion binding]; other site 1283331002330 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1283331002331 inter-subunit interface; other site 1283331002332 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1283331002333 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331002334 catalytic loop [active] 1283331002335 iron binding site [ion binding]; other site 1283331002336 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1283331002337 FAD binding pocket [chemical binding]; other site 1283331002338 FAD binding motif [chemical binding]; other site 1283331002339 phosphate binding motif [ion binding]; other site 1283331002340 beta-alpha-beta structure motif; other site 1283331002341 NAD binding pocket [chemical binding]; other site 1283331002342 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1283331002343 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1283331002344 putative NAD(P) binding site [chemical binding]; other site 1283331002345 active site 1283331002346 benzoate transport; Region: 2A0115; TIGR00895 1283331002347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331002348 putative substrate translocation pore; other site 1283331002349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331002350 putative substrate translocation pore; other site 1283331002351 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331002352 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283331002353 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283331002354 hexamer interface [polypeptide binding]; other site 1283331002355 Tautomerase enzyme; Region: Tautomerase; pfam01361 1283331002356 dimer interface [polypeptide binding]; other site 1283331002357 active site 2 [active] 1283331002358 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1283331002359 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283331002360 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1283331002361 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331002362 catalytic loop [active] 1283331002363 iron binding site [ion binding]; other site 1283331002364 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1283331002365 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 1283331002366 tetramer interface [polypeptide binding]; other site 1283331002367 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 1283331002368 tetramer interface [polypeptide binding]; other site 1283331002369 active site 1283331002370 Fe binding site [ion binding]; other site 1283331002371 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 1283331002372 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1283331002373 NAD binding site [chemical binding]; other site 1283331002374 catalytic residues [active] 1283331002375 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1283331002376 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1283331002377 active site 1283331002378 catalytic residues [active] 1283331002379 metal binding site [ion binding]; metal-binding site 1283331002380 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1283331002381 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1283331002382 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1283331002383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331002384 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 1283331002385 dimerizarion interface [polypeptide binding]; other site 1283331002386 CrgA pocket; other site 1283331002387 substrate binding pocket [chemical binding]; other site 1283331002388 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1283331002389 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1283331002390 active site 1 [active] 1283331002391 dimer interface [polypeptide binding]; other site 1283331002392 hexamer interface [polypeptide binding]; other site 1283331002393 active site 2 [active] 1283331002394 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1283331002395 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 1283331002396 tetramer interface [polypeptide binding]; other site 1283331002397 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1283331002398 active site 1283331002399 metal binding site [ion binding]; metal-binding site 1283331002400 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1283331002401 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331002402 catalytic loop [active] 1283331002403 iron binding site [ion binding]; other site 1283331002404 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 1283331002405 FAD binding pocket [chemical binding]; other site 1283331002406 FAD binding motif [chemical binding]; other site 1283331002407 phosphate binding motif [ion binding]; other site 1283331002408 beta-alpha-beta structure motif; other site 1283331002409 NAD binding pocket [chemical binding]; other site 1283331002410 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 1283331002411 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 1283331002412 dimerization interface [polypeptide binding]; other site 1283331002413 putative path to active site cavity [active] 1283331002414 diiron center [ion binding]; other site 1283331002415 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 1283331002416 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 1283331002417 dimerization interface [polypeptide binding]; other site 1283331002418 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 1283331002419 Activator of aromatic catabolism; Region: XylR_N; pfam06505 1283331002420 V4R domain; Region: V4R; pfam02830 1283331002421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331002422 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1283331002423 Walker A motif; other site 1283331002424 ATP binding site [chemical binding]; other site 1283331002425 Walker B motif; other site 1283331002426 arginine finger; other site 1283331002427 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331002428 Putative addiction module component; Region: Unstab_antitox; cl09921 1283331002429 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1283331002430 Domain of unknown function; Region: DUF331; cl01149 1283331002431 Staphylococcal nuclease homologues; Region: SNc; smart00318 1283331002432 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1283331002433 Catalytic site; other site 1283331002434 Domain of unknown function; Region: DUF331; cl01149 1283331002435 YfbU domain; Region: YfbU; cl01137 1283331002436 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1283331002437 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1283331002438 Lipopolysaccharide-assembly; Region: LptE; cl01125 1283331002439 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1283331002440 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1283331002441 HIGH motif; other site 1283331002442 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1283331002443 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1283331002444 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1283331002445 active site 1283331002446 KMSKS motif; other site 1283331002447 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1283331002448 tRNA binding surface [nucleotide binding]; other site 1283331002449 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1283331002450 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1283331002451 putative active site [active] 1283331002452 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1283331002453 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1283331002454 putative active site [active] 1283331002455 catalytic triad [active] 1283331002456 putative dimer interface [polypeptide binding]; other site 1283331002457 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1283331002458 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1283331002459 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1283331002460 metal-binding heat shock protein; Provisional; Region: PRK00016 1283331002461 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1283331002462 PhoH-like protein; Region: PhoH; pfam02562 1283331002463 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1283331002464 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1283331002465 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331002466 FeS/SAM binding site; other site 1283331002467 TRAM domain; Region: TRAM; pfam01938 1283331002468 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283331002469 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331002470 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331002471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283331002472 Integrase core domain; Region: rve; pfam00665 1283331002473 Integrase core domain; Region: rve_3; pfam13683 1283331002474 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 1283331002475 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1283331002476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331002477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331002478 dimerization interface [polypeptide binding]; other site 1283331002479 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1283331002480 rhamnose-proton symporter; Provisional; Region: PRK13499 1283331002481 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1283331002482 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283331002483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331002484 NAD(P) binding site [chemical binding]; other site 1283331002485 active site 1283331002486 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1283331002487 Amidohydrolase; Region: Amidohydro_2; pfam04909 1283331002488 active site 1283331002489 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283331002490 trimer interface; other site 1283331002491 sugar binding site [chemical binding]; other site 1283331002492 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1283331002493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331002494 putative substrate translocation pore; other site 1283331002495 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1283331002496 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1283331002497 putative active site pocket [active] 1283331002498 putative metal binding site [ion binding]; other site 1283331002499 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1283331002500 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1283331002501 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283331002502 NAD binding site [chemical binding]; other site 1283331002503 catalytic residues [active] 1283331002504 substrate binding site [chemical binding]; other site 1283331002505 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1283331002506 Sel1-like repeats; Region: SEL1; smart00671 1283331002507 Sel1-like repeats; Region: SEL1; smart00671 1283331002508 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1283331002509 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283331002510 inhibitor-cofactor binding pocket; inhibition site 1283331002511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331002512 catalytic residue [active] 1283331002513 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1283331002514 thiamine phosphate binding site [chemical binding]; other site 1283331002515 active site 1283331002516 pyrophosphate binding site [ion binding]; other site 1283331002517 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1283331002518 dimer interface [polypeptide binding]; other site 1283331002519 substrate binding site [chemical binding]; other site 1283331002520 ATP binding site [chemical binding]; other site 1283331002521 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1283331002522 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331002523 active site 1283331002524 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 1283331002525 dimer interface [polypeptide binding]; other site 1283331002526 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 1283331002527 active site 1283331002528 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283331002529 catalytic residues [active] 1283331002530 substrate binding site [chemical binding]; other site 1283331002531 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1283331002532 IucA / IucC family; Region: IucA_IucC; pfam04183 1283331002533 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1283331002534 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1283331002535 IucA / IucC family; Region: IucA_IucC; pfam04183 1283331002536 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1283331002537 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1283331002538 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1283331002539 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331002540 N-terminal plug; other site 1283331002541 ligand-binding site [chemical binding]; other site 1283331002542 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1283331002543 AMP nucleosidase; Provisional; Region: PRK08292 1283331002544 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1283331002545 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1283331002546 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283331002547 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1283331002548 UreF; Region: UreF; pfam01730 1283331002549 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1283331002550 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1283331002551 dimer interface [polypeptide binding]; other site 1283331002552 catalytic residues [active] 1283331002553 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283331002554 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283331002555 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283331002556 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1283331002557 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1283331002558 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283331002559 transcriptional activator TtdR; Provisional; Region: PRK09801 1283331002560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331002561 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1283331002562 putative effector binding pocket; other site 1283331002563 putative dimerization interface [polypeptide binding]; other site 1283331002564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331002565 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331002566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1283331002567 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1283331002568 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1283331002569 DNA binding site [nucleotide binding] 1283331002570 DNA-binding interface [nucleotide binding]; DNA binding site 1283331002571 domain linker motif; other site 1283331002572 Integrase core domain; Region: rve; pfam00665 1283331002573 transposase/IS protein; Provisional; Region: PRK09183 1283331002574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331002575 Walker A motif; other site 1283331002576 ATP binding site [chemical binding]; other site 1283331002577 Walker B motif; other site 1283331002578 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331002579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331002580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331002581 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331002582 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331002583 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283331002584 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283331002585 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1283331002586 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283331002587 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1283331002588 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283331002589 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 1283331002590 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1283331002591 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283331002592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331002593 Walker A/P-loop; other site 1283331002594 ATP binding site [chemical binding]; other site 1283331002595 Q-loop/lid; other site 1283331002596 ABC transporter signature motif; other site 1283331002597 Walker B; other site 1283331002598 D-loop; other site 1283331002599 H-loop/switch region; other site 1283331002600 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1283331002601 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1283331002602 catalytic residues [active] 1283331002603 hinge region; other site 1283331002604 alpha helical domain; other site 1283331002605 Condensation domain; Region: Condensation; pfam00668 1283331002606 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331002607 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1283331002608 acyl-activating enzyme (AAE) consensus motif; other site 1283331002609 AMP binding site [chemical binding]; other site 1283331002610 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331002611 Condensation domain; Region: Condensation; pfam00668 1283331002612 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283331002613 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283331002614 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1283331002615 acyl-activating enzyme (AAE) consensus motif; other site 1283331002616 AMP binding site [chemical binding]; other site 1283331002617 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331002618 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1283331002619 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1283331002620 active site 1283331002621 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1283331002622 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283331002623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331002624 Walker A/P-loop; other site 1283331002625 ATP binding site [chemical binding]; other site 1283331002626 Q-loop/lid; other site 1283331002627 ABC transporter signature motif; other site 1283331002628 Walker B; other site 1283331002629 D-loop; other site 1283331002630 H-loop/switch region; other site 1283331002631 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1283331002632 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1283331002633 catalytic residues [active] 1283331002634 hinge region; other site 1283331002635 alpha helical domain; other site 1283331002636 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1283331002637 putative transposase OrfB; Reviewed; Region: PHA02517 1283331002638 HTH-like domain; Region: HTH_21; pfam13276 1283331002639 Integrase core domain; Region: rve; pfam00665 1283331002640 Integrase core domain; Region: rve_3; pfam13683 1283331002641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331002642 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331002643 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331002644 Transposase; Region: HTH_Tnp_1; cl17663 1283331002645 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283331002646 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1283331002647 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1283331002648 hypothetical protein; Provisional; Region: PRK14812 1283331002649 substrate binding site [chemical binding]; other site 1283331002650 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1283331002651 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1283331002652 substrate binding site [chemical binding]; other site 1283331002653 ligand binding site [chemical binding]; other site 1283331002654 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1283331002655 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1283331002656 tellurite resistance protein terB; Region: terB; cd07176 1283331002657 putative metal binding site [ion binding]; other site 1283331002658 Predicted integral membrane protein [Function unknown]; Region: COG0392 1283331002659 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1283331002660 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1283331002661 subunit interactions [polypeptide binding]; other site 1283331002662 active site 1283331002663 flap region; other site 1283331002664 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1283331002665 gamma-beta subunit interface [polypeptide binding]; other site 1283331002666 alpha-beta subunit interface [polypeptide binding]; other site 1283331002667 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1283331002668 alpha-gamma subunit interface [polypeptide binding]; other site 1283331002669 beta-gamma subunit interface [polypeptide binding]; other site 1283331002670 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1283331002671 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1283331002672 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1283331002673 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1283331002674 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1283331002675 pseudouridine synthase; Region: TIGR00093 1283331002676 active site 1283331002677 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 1283331002678 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1283331002679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331002680 dimerization interface [polypeptide binding]; other site 1283331002681 putative DNA binding site [nucleotide binding]; other site 1283331002682 putative Zn2+ binding site [ion binding]; other site 1283331002683 AsnC family; Region: AsnC_trans_reg; pfam01037 1283331002684 Cation efflux family; Region: Cation_efflux; cl00316 1283331002685 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1283331002686 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1283331002687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283331002688 ATP binding site [chemical binding]; other site 1283331002689 putative Mg++ binding site [ion binding]; other site 1283331002690 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331002691 nucleotide binding region [chemical binding]; other site 1283331002692 ATP-binding site [chemical binding]; other site 1283331002693 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1283331002694 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1283331002695 short chain dehydrogenase; Provisional; Region: PRK06181 1283331002696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331002697 NAD(P) binding site [chemical binding]; other site 1283331002698 active site 1283331002699 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1283331002700 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1283331002701 ATP binding site [chemical binding]; other site 1283331002702 Mg++ binding site [ion binding]; other site 1283331002703 motif III; other site 1283331002704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331002705 nucleotide binding region [chemical binding]; other site 1283331002706 ATP-binding site [chemical binding]; other site 1283331002707 hypothetical protein; Provisional; Region: PRK07236 1283331002708 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1283331002709 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1283331002710 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1283331002711 putative active site [active] 1283331002712 Zn binding site [ion binding]; other site 1283331002713 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1283331002714 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1283331002715 heme binding site [chemical binding]; other site 1283331002716 ferroxidase pore; other site 1283331002717 ferroxidase diiron center [ion binding]; other site 1283331002718 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1283331002719 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1283331002720 DNA binding residues [nucleotide binding] 1283331002721 dimer interface [polypeptide binding]; other site 1283331002722 copper binding site [ion binding]; other site 1283331002723 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1283331002724 metal-binding site [ion binding] 1283331002725 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1283331002726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331002727 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1283331002728 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1283331002729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331002730 putative substrate translocation pore; other site 1283331002731 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1283331002732 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1283331002733 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1283331002734 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283331002735 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1283331002736 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1283331002737 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1283331002738 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1283331002739 active site 1283331002740 nucleophile elbow; other site 1283331002741 selenophosphate synthetase; Provisional; Region: PRK00943 1283331002742 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1283331002743 dimerization interface [polypeptide binding]; other site 1283331002744 putative ATP binding site [chemical binding]; other site 1283331002745 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1283331002746 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1283331002747 active site residue [active] 1283331002748 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283331002749 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1283331002750 polyribonucleotide nucleotidyltransferase; Provisional; Region: PLN00207 1283331002751 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1283331002752 Haem-binding domain; Region: Haem_bd; pfam14376 1283331002753 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1283331002754 HopJ type III effector protein; Region: HopJ; pfam08888 1283331002755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1283331002756 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1283331002757 homooctamer interface [polypeptide binding]; other site 1283331002758 active site 1283331002759 dihydromonapterin reductase; Provisional; Region: PRK06483 1283331002760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331002761 NAD(P) binding site [chemical binding]; other site 1283331002762 active site 1283331002763 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1283331002764 Coenzyme A transferase; Region: CoA_trans; cl17247 1283331002765 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1283331002766 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 1283331002767 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1283331002768 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1283331002769 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1283331002770 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1283331002771 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1283331002772 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1283331002773 Malonate transporter MadL subunit; Region: MadL; pfam03817 1283331002774 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 1283331002775 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1283331002776 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1283331002777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331002778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331002779 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1283331002780 putative dimerization interface [polypeptide binding]; other site 1283331002781 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1283331002782 diiron binding motif [ion binding]; other site 1283331002783 Sulfatase; Region: Sulfatase; pfam00884 1283331002784 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1283331002785 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283331002786 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331002787 N-terminal plug; other site 1283331002788 ligand-binding site [chemical binding]; other site 1283331002789 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283331002790 FecR protein; Region: FecR; pfam04773 1283331002791 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1283331002792 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331002793 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331002794 DNA binding residues [nucleotide binding] 1283331002795 putative cation:proton antiport protein; Provisional; Region: PRK10669 1283331002796 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1283331002797 TrkA-N domain; Region: TrkA_N; pfam02254 1283331002798 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 1283331002799 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1283331002800 Ligand binding site [chemical binding]; other site 1283331002801 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1283331002802 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1283331002803 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1283331002804 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1283331002805 oxidoreductase; Provisional; Region: PRK10015 1283331002806 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283331002807 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1283331002808 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1283331002809 diiron binding motif [ion binding]; other site 1283331002810 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1283331002811 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1283331002812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331002813 active site 1283331002814 phosphorylation site [posttranslational modification] 1283331002815 intermolecular recognition site; other site 1283331002816 dimerization interface [polypeptide binding]; other site 1283331002817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331002818 DNA binding site [nucleotide binding] 1283331002819 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1283331002820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331002821 dimer interface [polypeptide binding]; other site 1283331002822 phosphorylation site [posttranslational modification] 1283331002823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331002824 ATP binding site [chemical binding]; other site 1283331002825 Mg2+ binding site [ion binding]; other site 1283331002826 G-X-G motif; other site 1283331002827 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1283331002828 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1283331002829 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1283331002830 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283331002831 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1283331002832 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283331002833 tonB-system energizer ExbB; Region: exbB; TIGR02797 1283331002834 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331002835 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1283331002836 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1283331002837 acyl-activating enzyme (AAE) consensus motif; other site 1283331002838 putative AMP binding site [chemical binding]; other site 1283331002839 putative active site [active] 1283331002840 putative CoA binding site [chemical binding]; other site 1283331002841 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331002842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331002843 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1283331002844 dimerization interface [polypeptide binding]; other site 1283331002845 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283331002846 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331002847 active site 1283331002848 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1283331002849 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283331002850 substrate binding site [chemical binding]; other site 1283331002851 oxyanion hole (OAH) forming residues; other site 1283331002852 trimer interface [polypeptide binding]; other site 1283331002853 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1283331002854 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1283331002855 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1283331002856 enoyl-CoA hydratase; Provisional; Region: PRK05862 1283331002857 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283331002858 substrate binding site [chemical binding]; other site 1283331002859 oxyanion hole (OAH) forming residues; other site 1283331002860 trimer interface [polypeptide binding]; other site 1283331002861 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1283331002862 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1283331002863 tetrameric interface [polypeptide binding]; other site 1283331002864 NAD binding site [chemical binding]; other site 1283331002865 catalytic residues [active] 1283331002866 transcriptional regulator; Provisional; Region: PRK10632 1283331002867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331002868 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331002869 putative effector binding pocket; other site 1283331002870 dimerization interface [polypeptide binding]; other site 1283331002871 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1283331002872 B1 nucleotide binding pocket [chemical binding]; other site 1283331002873 B2 nucleotide binding pocket [chemical binding]; other site 1283331002874 CAS motifs; other site 1283331002875 active site 1283331002876 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1283331002877 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1283331002878 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1283331002879 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1283331002880 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1283331002881 NAD binding site [chemical binding]; other site 1283331002882 Phe binding site; other site 1283331002883 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1283331002884 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1283331002885 TPP-binding site [chemical binding]; other site 1283331002886 tetramer interface [polypeptide binding]; other site 1283331002887 heterodimer interface [polypeptide binding]; other site 1283331002888 phosphorylation loop region [posttranslational modification] 1283331002889 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1283331002890 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1283331002891 alpha subunit interface [polypeptide binding]; other site 1283331002892 TPP binding site [chemical binding]; other site 1283331002893 heterodimer interface [polypeptide binding]; other site 1283331002894 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283331002895 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1283331002896 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283331002897 E3 interaction surface; other site 1283331002898 lipoyl attachment site [posttranslational modification]; other site 1283331002899 e3 binding domain; Region: E3_binding; pfam02817 1283331002900 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1283331002901 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1283331002902 Predicted membrane protein [Function unknown]; Region: COG3223 1283331002903 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1283331002904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283331002905 ATP binding site [chemical binding]; other site 1283331002906 putative Mg++ binding site [ion binding]; other site 1283331002907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331002908 nucleotide binding region [chemical binding]; other site 1283331002909 ATP-binding site [chemical binding]; other site 1283331002910 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283331002911 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283331002912 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1283331002913 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1283331002914 Substrate binding site; other site 1283331002915 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1283331002916 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 1283331002917 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1283331002918 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 1283331002919 active site 1283331002920 Right handed beta helix region; Region: Beta_helix; pfam13229 1283331002921 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1283331002922 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1283331002923 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1283331002924 Sel1-like repeats; Region: SEL1; smart00671 1283331002925 Sel1-like repeats; Region: SEL1; smart00671 1283331002926 PilZ domain; Region: PilZ; pfam07238 1283331002927 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331002928 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283331002929 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1283331002930 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1283331002931 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1283331002932 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1283331002933 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1283331002934 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1283331002935 Small hydrophilic plant seed protein; Region: LEA_5; pfam00477 1283331002936 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1283331002937 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1283331002938 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1283331002939 Predicted membrane protein [Function unknown]; Region: COG2323 1283331002940 short chain dehydrogenase; Provisional; Region: PRK06701 1283331002941 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1283331002942 NAD binding site [chemical binding]; other site 1283331002943 metal binding site [ion binding]; metal-binding site 1283331002944 active site 1283331002945 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1283331002946 dinuclear metal binding motif [ion binding]; other site 1283331002947 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1283331002948 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283331002949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331002950 active site 1283331002951 phosphorylation site [posttranslational modification] 1283331002952 intermolecular recognition site; other site 1283331002953 dimerization interface [polypeptide binding]; other site 1283331002954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331002955 Walker A motif; other site 1283331002956 ATP binding site [chemical binding]; other site 1283331002957 Walker B motif; other site 1283331002958 arginine finger; other site 1283331002959 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331002960 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1283331002961 Predicted membrane protein [Function unknown]; Region: COG4244 1283331002962 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1283331002963 Cytochrome c; Region: Cytochrom_C; cl11414 1283331002964 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1283331002965 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1283331002966 D-pathway; other site 1283331002967 Putative ubiquinol binding site [chemical binding]; other site 1283331002968 Low-spin heme (heme b) binding site [chemical binding]; other site 1283331002969 Putative water exit pathway; other site 1283331002970 Binuclear center (heme o3/CuB) [ion binding]; other site 1283331002971 K-pathway; other site 1283331002972 Putative proton exit pathway; other site 1283331002973 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1283331002974 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1283331002975 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1283331002976 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1283331002977 active site 1283331002978 hypothetical protein; Validated; Region: PRK02101 1283331002979 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1283331002980 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1283331002981 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1283331002982 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1283331002983 putative active site [active] 1283331002984 PhoH-like protein; Region: PhoH; pfam02562 1283331002985 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1283331002986 trimer interface [polypeptide binding]; other site 1283331002987 dimer interface [polypeptide binding]; other site 1283331002988 putative active site [active] 1283331002989 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1283331002990 MoaE interaction surface [polypeptide binding]; other site 1283331002991 MoeB interaction surface [polypeptide binding]; other site 1283331002992 thiocarboxylated glycine; other site 1283331002993 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1283331002994 MoaD interaction [polypeptide binding]; other site 1283331002995 active site residues [active] 1283331002996 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 1283331002997 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1283331002998 ATP binding site [chemical binding]; other site 1283331002999 Mg++ binding site [ion binding]; other site 1283331003000 motif III; other site 1283331003001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331003002 nucleotide binding region [chemical binding]; other site 1283331003003 ATP-binding site [chemical binding]; other site 1283331003004 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1283331003005 putative hydrolase; Provisional; Region: PRK11460 1283331003006 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283331003007 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331003008 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331003009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283331003010 Integrase core domain; Region: rve; pfam00665 1283331003011 Integrase core domain; Region: rve_3; pfam13683 1283331003012 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331003013 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1283331003014 GIY-YIG motif/motif A; other site 1283331003015 putative active site [active] 1283331003016 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1283331003017 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1283331003018 C-terminal domain interface [polypeptide binding]; other site 1283331003019 GSH binding site (G-site) [chemical binding]; other site 1283331003020 dimer interface [polypeptide binding]; other site 1283331003021 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1283331003022 N-terminal domain interface [polypeptide binding]; other site 1283331003023 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1283331003024 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1283331003025 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1283331003026 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1283331003027 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 1283331003028 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 1283331003029 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1283331003030 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1283331003031 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1283331003032 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1283331003033 GAF domain; Region: GAF; pfam01590 1283331003034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331003035 Walker A motif; other site 1283331003036 ATP binding site [chemical binding]; other site 1283331003037 Walker B motif; other site 1283331003038 arginine finger; other site 1283331003039 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331003040 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1283331003041 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283331003042 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1283331003043 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1283331003044 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1283331003045 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1283331003046 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1283331003047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331003048 motif II; other site 1283331003049 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1283331003050 transcriptional regulator; Provisional; Region: PRK10632 1283331003051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331003052 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331003053 putative effector binding pocket; other site 1283331003054 dimerization interface [polypeptide binding]; other site 1283331003055 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1283331003056 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1283331003057 putative active site [active] 1283331003058 metal binding site [ion binding]; metal-binding site 1283331003059 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283331003060 classical (c) SDRs; Region: SDR_c; cd05233 1283331003061 NAD(P) binding site [chemical binding]; other site 1283331003062 active site 1283331003063 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 1283331003064 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1283331003065 exonuclease subunit SbcD; Provisional; Region: PRK10966 1283331003066 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1283331003067 active site 1283331003068 metal binding site [ion binding]; metal-binding site 1283331003069 DNA binding site [nucleotide binding] 1283331003070 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1283331003071 exonuclease subunit SbcC; Provisional; Region: PRK10246 1283331003072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331003073 Walker A/P-loop; other site 1283331003074 ATP binding site [chemical binding]; other site 1283331003075 Q-loop/lid; other site 1283331003076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331003077 ABC transporter signature motif; other site 1283331003078 Walker B; other site 1283331003079 D-loop; other site 1283331003080 H-loop/switch region; other site 1283331003081 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1283331003082 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1283331003083 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1283331003084 Transporter associated domain; Region: CorC_HlyC; smart01091 1283331003085 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1283331003086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331003087 S-adenosylmethionine binding site [chemical binding]; other site 1283331003088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331003089 PAS domain; Region: PAS_9; pfam13426 1283331003090 putative active site [active] 1283331003091 heme pocket [chemical binding]; other site 1283331003092 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331003093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331003094 metal binding site [ion binding]; metal-binding site 1283331003095 active site 1283331003096 I-site; other site 1283331003097 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283331003098 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1283331003099 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1283331003100 HIGH motif; other site 1283331003101 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1283331003102 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1283331003103 active site 1283331003104 KMSKS motif; other site 1283331003105 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1283331003106 tRNA binding surface [nucleotide binding]; other site 1283331003107 anticodon binding site; other site 1283331003108 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1283331003109 DNA polymerase III subunit chi; Validated; Region: PRK05728 1283331003110 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1283331003111 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1283331003112 interface (dimer of trimers) [polypeptide binding]; other site 1283331003113 Substrate-binding/catalytic site; other site 1283331003114 Zn-binding sites [ion binding]; other site 1283331003115 Predicted permeases [General function prediction only]; Region: COG0795 1283331003116 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1283331003117 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1283331003118 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1283331003119 RDD family; Region: RDD; pfam06271 1283331003120 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1283331003121 DNA-binding site [nucleotide binding]; DNA binding site 1283331003122 RNA-binding motif; other site 1283331003123 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283331003124 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1283331003125 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1283331003126 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1283331003127 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1283331003128 Riboflavin kinase; Region: Flavokinase; smart00904 1283331003129 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1283331003130 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1283331003131 active site 1283331003132 HIGH motif; other site 1283331003133 nucleotide binding site [chemical binding]; other site 1283331003134 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1283331003135 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1283331003136 active site 1283331003137 KMSKS motif; other site 1283331003138 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1283331003139 tRNA binding surface [nucleotide binding]; other site 1283331003140 anticodon binding site; other site 1283331003141 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1283331003142 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1283331003143 lipoprotein signal peptidase; Provisional; Region: PRK14787 1283331003144 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1283331003145 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283331003146 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1283331003147 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1283331003148 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1283331003149 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1283331003150 Type II transport protein GspH; Region: GspH; pfam12019 1283331003151 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1283331003152 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1283331003153 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 1283331003154 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1283331003155 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283331003156 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1283331003157 NAD synthetase; Provisional; Region: PRK13981 1283331003158 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1283331003159 multimer interface [polypeptide binding]; other site 1283331003160 active site 1283331003161 catalytic triad [active] 1283331003162 protein interface 1 [polypeptide binding]; other site 1283331003163 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1283331003164 homodimer interface [polypeptide binding]; other site 1283331003165 NAD binding pocket [chemical binding]; other site 1283331003166 ATP binding pocket [chemical binding]; other site 1283331003167 Mg binding site [ion binding]; other site 1283331003168 active-site loop [active] 1283331003169 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1283331003170 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1283331003171 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1283331003172 RNA binding surface [nucleotide binding]; other site 1283331003173 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1283331003174 active site 1283331003175 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1283331003176 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1283331003177 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1283331003178 Clp amino terminal domain; Region: Clp_N; pfam02861 1283331003179 Clp amino terminal domain; Region: Clp_N; pfam02861 1283331003180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331003181 Walker A motif; other site 1283331003182 ATP binding site [chemical binding]; other site 1283331003183 Walker B motif; other site 1283331003184 arginine finger; other site 1283331003185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331003186 Walker A motif; other site 1283331003187 ATP binding site [chemical binding]; other site 1283331003188 Walker B motif; other site 1283331003189 arginine finger; other site 1283331003190 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1283331003191 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1283331003192 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283331003193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331003194 Walker A/P-loop; other site 1283331003195 ATP binding site [chemical binding]; other site 1283331003196 Q-loop/lid; other site 1283331003197 ABC transporter signature motif; other site 1283331003198 Walker B; other site 1283331003199 D-loop; other site 1283331003200 H-loop/switch region; other site 1283331003201 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1283331003202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283331003203 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 1283331003204 putative acetyltransferase; Provisional; Region: PRK03624 1283331003205 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1283331003206 Coenzyme A binding pocket [chemical binding]; other site 1283331003207 Predicted membrane protein [Function unknown]; Region: COG3235 1283331003208 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1283331003209 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1283331003210 CoA-binding site [chemical binding]; other site 1283331003211 ATP-binding [chemical binding]; other site 1283331003212 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1283331003213 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1283331003214 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1283331003215 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1283331003216 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283331003217 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283331003218 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1283331003219 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1283331003220 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1283331003221 Walker A motif; other site 1283331003222 ATP binding site [chemical binding]; other site 1283331003223 Walker B motif; other site 1283331003224 Pilin (bacterial filament); Region: Pilin; pfam00114 1283331003225 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 1283331003226 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1283331003227 dimerization interface [polypeptide binding]; other site 1283331003228 active site 1283331003229 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1283331003230 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1283331003231 amidase catalytic site [active] 1283331003232 Zn binding residues [ion binding]; other site 1283331003233 substrate binding site [chemical binding]; other site 1283331003234 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 1283331003235 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1283331003236 active site 1283331003237 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1283331003238 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1283331003239 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1283331003240 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1283331003241 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1283331003242 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1283331003243 putative active site [active] 1283331003244 putative metal binding site [ion binding]; other site 1283331003245 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1283331003246 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1283331003247 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283331003248 DNA binding site [nucleotide binding] 1283331003249 domain linker motif; other site 1283331003250 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1283331003251 dimerization interface [polypeptide binding]; other site 1283331003252 ligand binding site [chemical binding]; other site 1283331003253 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1283331003254 active site 1283331003255 phosphorylation site [posttranslational modification] 1283331003256 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1283331003257 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1283331003258 dimerization domain swap beta strand [polypeptide binding]; other site 1283331003259 regulatory protein interface [polypeptide binding]; other site 1283331003260 active site 1283331003261 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1283331003262 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1283331003263 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1283331003264 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1283331003265 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1283331003266 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1283331003267 putative substrate binding site [chemical binding]; other site 1283331003268 putative ATP binding site [chemical binding]; other site 1283331003269 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1283331003270 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1283331003271 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1283331003272 active site 1283331003273 P-loop; other site 1283331003274 phosphorylation site [posttranslational modification] 1283331003275 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1283331003276 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283331003277 classical (c) SDRs; Region: SDR_c; cd05233 1283331003278 NAD(P) binding site [chemical binding]; other site 1283331003279 active site 1283331003280 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1283331003281 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1283331003282 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1283331003283 G1 box; other site 1283331003284 putative GEF interaction site [polypeptide binding]; other site 1283331003285 GTP/Mg2+ binding site [chemical binding]; other site 1283331003286 Switch I region; other site 1283331003287 G2 box; other site 1283331003288 G3 box; other site 1283331003289 Switch II region; other site 1283331003290 G4 box; other site 1283331003291 G5 box; other site 1283331003292 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1283331003293 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1283331003294 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1283331003295 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1283331003296 Surface antigen; Region: Bac_surface_Ag; pfam01103 1283331003297 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1283331003298 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1283331003299 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 1283331003300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331003301 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283331003302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331003303 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1283331003304 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1283331003305 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1283331003306 dimer interface [polypeptide binding]; other site 1283331003307 active site 1283331003308 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283331003309 catalytic residues [active] 1283331003310 substrate binding site [chemical binding]; other site 1283331003311 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1283331003312 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331003313 N-terminal plug; other site 1283331003314 ligand-binding site [chemical binding]; other site 1283331003315 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1283331003316 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1283331003317 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1283331003318 active site 1283331003319 substrate binding site [chemical binding]; other site 1283331003320 FMN binding site [chemical binding]; other site 1283331003321 putative catalytic residues [active] 1283331003322 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1283331003323 Flavodoxin; Region: Flavodoxin_1; pfam00258 1283331003324 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1283331003325 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1283331003326 FAD binding pocket [chemical binding]; other site 1283331003327 FAD binding motif [chemical binding]; other site 1283331003328 catalytic residues [active] 1283331003329 NAD binding pocket [chemical binding]; other site 1283331003330 phosphate binding motif [ion binding]; other site 1283331003331 beta-alpha-beta structure motif; other site 1283331003332 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1283331003333 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 1283331003334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 1283331003335 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1283331003336 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1283331003337 Sel1-like repeats; Region: SEL1; smart00671 1283331003338 Sel1-like repeats; Region: SEL1; smart00671 1283331003339 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1283331003340 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1283331003341 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331003342 N-terminal plug; other site 1283331003343 ligand-binding site [chemical binding]; other site 1283331003344 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1283331003345 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1283331003346 Flavodoxin; Region: Flavodoxin_1; pfam00258 1283331003347 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1283331003348 FAD binding pocket [chemical binding]; other site 1283331003349 FAD binding motif [chemical binding]; other site 1283331003350 catalytic residues [active] 1283331003351 NAD binding pocket [chemical binding]; other site 1283331003352 phosphate binding motif [ion binding]; other site 1283331003353 beta-alpha-beta structure motif; other site 1283331003354 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1283331003355 putative active site [active] 1283331003356 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1283331003357 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1283331003358 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1283331003359 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1283331003360 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283331003361 Walker A/P-loop; other site 1283331003362 ATP binding site [chemical binding]; other site 1283331003363 Q-loop/lid; other site 1283331003364 ABC transporter signature motif; other site 1283331003365 Walker B; other site 1283331003366 D-loop; other site 1283331003367 H-loop/switch region; other site 1283331003368 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1283331003369 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1283331003370 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283331003371 Walker A/P-loop; other site 1283331003372 ATP binding site [chemical binding]; other site 1283331003373 Q-loop/lid; other site 1283331003374 ABC transporter signature motif; other site 1283331003375 Walker B; other site 1283331003376 D-loop; other site 1283331003377 H-loop/switch region; other site 1283331003378 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1283331003379 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1283331003380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1283331003381 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1283331003382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331003383 dimer interface [polypeptide binding]; other site 1283331003384 conserved gate region; other site 1283331003385 putative PBP binding loops; other site 1283331003386 ABC-ATPase subunit interface; other site 1283331003387 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1283331003388 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1283331003389 peptide binding site [polypeptide binding]; other site 1283331003390 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1283331003391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331003392 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1283331003393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331003394 active site 1283331003395 phosphorylation site [posttranslational modification] 1283331003396 intermolecular recognition site; other site 1283331003397 dimerization interface [polypeptide binding]; other site 1283331003398 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331003399 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1283331003400 Predicted permeases [General function prediction only]; Region: COG0679 1283331003401 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1283331003402 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1283331003403 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1283331003404 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1283331003405 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1283331003406 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1283331003407 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1283331003408 GatB domain; Region: GatB_Yqey; smart00845 1283331003409 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1283331003410 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1283331003411 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1283331003412 rod shape-determining protein MreB; Provisional; Region: PRK13927 1283331003413 MreB and similar proteins; Region: MreB_like; cd10225 1283331003414 nucleotide binding site [chemical binding]; other site 1283331003415 Mg binding site [ion binding]; other site 1283331003416 putative protofilament interaction site [polypeptide binding]; other site 1283331003417 RodZ interaction site [polypeptide binding]; other site 1283331003418 rod shape-determining protein MreC; Provisional; Region: PRK13922 1283331003419 rod shape-determining protein MreC; Region: MreC; pfam04085 1283331003420 rod shape-determining protein MreD; Region: MreD; cl01087 1283331003421 Maf-like protein; Region: Maf; pfam02545 1283331003422 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1283331003423 active site 1283331003424 dimer interface [polypeptide binding]; other site 1283331003425 ribonuclease G; Provisional; Region: PRK11712 1283331003426 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1283331003427 homodimer interface [polypeptide binding]; other site 1283331003428 oligonucleotide binding site [chemical binding]; other site 1283331003429 TIGR02099 family protein; Region: TIGR02099 1283331003430 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1283331003431 nitrilase; Region: PLN02798 1283331003432 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1283331003433 putative active site [active] 1283331003434 catalytic triad [active] 1283331003435 dimer interface [polypeptide binding]; other site 1283331003436 protease TldD; Provisional; Region: tldD; PRK10735 1283331003437 hypothetical protein; Provisional; Region: PRK05255 1283331003438 peptidase PmbA; Provisional; Region: PRK11040 1283331003439 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1283331003440 dimerization domain swap beta strand [polypeptide binding]; other site 1283331003441 regulatory protein interface [polypeptide binding]; other site 1283331003442 active site 1283331003443 regulatory phosphorylation site [posttranslational modification]; other site 1283331003444 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1283331003445 AAA domain; Region: AAA_18; pfam13238 1283331003446 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1283331003447 active site 1283331003448 phosphorylation site [posttranslational modification] 1283331003449 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1283331003450 30S subunit binding site; other site 1283331003451 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1283331003452 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1283331003453 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1283331003454 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1283331003455 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1283331003456 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1283331003457 Walker A/P-loop; other site 1283331003458 ATP binding site [chemical binding]; other site 1283331003459 Q-loop/lid; other site 1283331003460 ABC transporter signature motif; other site 1283331003461 Walker B; other site 1283331003462 D-loop; other site 1283331003463 H-loop/switch region; other site 1283331003464 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1283331003465 OstA-like protein; Region: OstA; pfam03968 1283331003466 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1283331003467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1283331003468 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1283331003469 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331003470 active site 1283331003471 motif I; other site 1283331003472 motif II; other site 1283331003473 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1283331003474 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1283331003475 putative active site [active] 1283331003476 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1283331003477 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1283331003478 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1283331003479 Walker A/P-loop; other site 1283331003480 ATP binding site [chemical binding]; other site 1283331003481 Q-loop/lid; other site 1283331003482 ABC transporter signature motif; other site 1283331003483 Walker B; other site 1283331003484 D-loop; other site 1283331003485 H-loop/switch region; other site 1283331003486 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1283331003487 Permease; Region: Permease; cl00510 1283331003488 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1283331003489 mce related protein; Region: MCE; pfam02470 1283331003490 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1283331003491 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1283331003492 anti sigma factor interaction site; other site 1283331003493 regulatory phosphorylation site [posttranslational modification]; other site 1283331003494 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1283331003495 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1283331003496 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1283331003497 hinge; other site 1283331003498 active site 1283331003499 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1283331003500 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1283331003501 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1283331003502 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1283331003503 NAD binding site [chemical binding]; other site 1283331003504 dimerization interface [polypeptide binding]; other site 1283331003505 product binding site; other site 1283331003506 substrate binding site [chemical binding]; other site 1283331003507 zinc binding site [ion binding]; other site 1283331003508 catalytic residues [active] 1283331003509 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1283331003510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283331003511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331003512 homodimer interface [polypeptide binding]; other site 1283331003513 catalytic residue [active] 1283331003514 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1283331003515 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1283331003516 protein binding site [polypeptide binding]; other site 1283331003517 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1283331003518 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1283331003519 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1283331003520 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1283331003521 Active Sites [active] 1283331003522 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1283331003523 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1283331003524 CysD dimerization site [polypeptide binding]; other site 1283331003525 G1 box; other site 1283331003526 putative GEF interaction site [polypeptide binding]; other site 1283331003527 GTP/Mg2+ binding site [chemical binding]; other site 1283331003528 Switch I region; other site 1283331003529 G2 box; other site 1283331003530 G3 box; other site 1283331003531 Switch II region; other site 1283331003532 G4 box; other site 1283331003533 G5 box; other site 1283331003534 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1283331003535 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1283331003536 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1283331003537 ligand-binding site [chemical binding]; other site 1283331003538 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1283331003539 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1283331003540 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283331003541 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1283331003542 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1283331003543 active site 1283331003544 HIGH motif; other site 1283331003545 dimer interface [polypeptide binding]; other site 1283331003546 KMSKS motif; other site 1283331003547 Predicted ATPase [General function prediction only]; Region: COG1485 1283331003548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1283331003549 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1283331003550 Active_site [active] 1283331003551 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1283331003552 23S rRNA interface [nucleotide binding]; other site 1283331003553 L3 interface [polypeptide binding]; other site 1283331003554 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1283331003555 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1283331003556 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1283331003557 [2Fe-2S] cluster binding site [ion binding]; other site 1283331003558 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1283331003559 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1283331003560 Qi binding site; other site 1283331003561 intrachain domain interface; other site 1283331003562 interchain domain interface [polypeptide binding]; other site 1283331003563 heme bH binding site [chemical binding]; other site 1283331003564 heme bL binding site [chemical binding]; other site 1283331003565 Qo binding site; other site 1283331003566 interchain domain interface [polypeptide binding]; other site 1283331003567 intrachain domain interface; other site 1283331003568 Qi binding site; other site 1283331003569 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1283331003570 Qo binding site; other site 1283331003571 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1283331003572 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1283331003573 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1283331003574 C-terminal domain interface [polypeptide binding]; other site 1283331003575 putative GSH binding site (G-site) [chemical binding]; other site 1283331003576 dimer interface [polypeptide binding]; other site 1283331003577 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1283331003578 N-terminal domain interface [polypeptide binding]; other site 1283331003579 dimer interface [polypeptide binding]; other site 1283331003580 substrate binding pocket (H-site) [chemical binding]; other site 1283331003581 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1283331003582 BON domain; Region: BON; pfam04972 1283331003583 BON domain; Region: BON; cl02771 1283331003584 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1283331003585 dimer interface [polypeptide binding]; other site 1283331003586 active site 1283331003587 hypothetical protein; Reviewed; Region: PRK12497 1283331003588 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1283331003589 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1283331003590 putative ligand binding site [chemical binding]; other site 1283331003591 Predicted methyltransferases [General function prediction only]; Region: COG0313 1283331003592 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1283331003593 putative SAM binding site [chemical binding]; other site 1283331003594 putative homodimer interface [polypeptide binding]; other site 1283331003595 cell division protein MraZ; Reviewed; Region: PRK00326 1283331003596 MraZ protein; Region: MraZ; pfam02381 1283331003597 MraZ protein; Region: MraZ; pfam02381 1283331003598 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1283331003599 MraW methylase family; Region: Methyltransf_5; cl17771 1283331003600 Cell division protein FtsL; Region: FtsL; pfam04999 1283331003601 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1283331003602 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1283331003603 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1283331003604 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1283331003605 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1283331003606 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283331003607 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1283331003608 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1283331003609 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1283331003610 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283331003611 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1283331003612 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1283331003613 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1283331003614 Mg++ binding site [ion binding]; other site 1283331003615 putative catalytic motif [active] 1283331003616 putative substrate binding site [chemical binding]; other site 1283331003617 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1283331003618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331003619 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283331003620 cell division protein FtsW; Region: ftsW; TIGR02614 1283331003621 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1283331003622 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1283331003623 active site 1283331003624 homodimer interface [polypeptide binding]; other site 1283331003625 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1283331003626 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1283331003627 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283331003628 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1283331003629 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1283331003630 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1283331003631 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1283331003632 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1283331003633 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1283331003634 Cell division protein FtsQ; Region: FtsQ; pfam03799 1283331003635 cell division protein FtsA; Region: ftsA; TIGR01174 1283331003636 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1283331003637 nucleotide binding site [chemical binding]; other site 1283331003638 Cell division protein FtsA; Region: FtsA; pfam14450 1283331003639 cell division protein FtsZ; Validated; Region: PRK09330 1283331003640 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1283331003641 nucleotide binding site [chemical binding]; other site 1283331003642 SulA interaction site; other site 1283331003643 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1283331003644 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1283331003645 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 1283331003646 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1283331003647 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1283331003648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1283331003649 nucleotide binding region [chemical binding]; other site 1283331003650 ATP-binding site [chemical binding]; other site 1283331003651 SEC-C motif; Region: SEC-C; pfam02810 1283331003652 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1283331003653 heterotetramer interface [polypeptide binding]; other site 1283331003654 active site pocket [active] 1283331003655 cleavage site 1283331003656 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1283331003657 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1283331003658 putative C-terminal domain interface [polypeptide binding]; other site 1283331003659 putative GSH binding site (G-site) [chemical binding]; other site 1283331003660 putative dimer interface [polypeptide binding]; other site 1283331003661 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1283331003662 putative N-terminal domain interface [polypeptide binding]; other site 1283331003663 putative dimer interface [polypeptide binding]; other site 1283331003664 putative substrate binding pocket (H-site) [chemical binding]; other site 1283331003665 hypothetical protein; Provisional; Region: PRK08999 1283331003666 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1283331003667 active site 1283331003668 8-oxo-dGMP binding site [chemical binding]; other site 1283331003669 nudix motif; other site 1283331003670 metal binding site [ion binding]; metal-binding site 1283331003671 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1283331003672 thiamine phosphate binding site [chemical binding]; other site 1283331003673 active site 1283331003674 pyrophosphate binding site [ion binding]; other site 1283331003675 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1283331003676 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1283331003677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331003678 dimerization interface [polypeptide binding]; other site 1283331003679 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1283331003680 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331003681 putative active site [active] 1283331003682 heme pocket [chemical binding]; other site 1283331003683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331003684 dimer interface [polypeptide binding]; other site 1283331003685 phosphorylation site [posttranslational modification] 1283331003686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331003687 ATP binding site [chemical binding]; other site 1283331003688 Mg2+ binding site [ion binding]; other site 1283331003689 G-X-G motif; other site 1283331003690 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 1283331003691 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1283331003692 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1283331003693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1283331003694 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1283331003695 muropeptide transporter; Validated; Region: ampG; cl17669 1283331003696 muropeptide transporter; Validated; Region: ampG; cl17669 1283331003697 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1283331003698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331003699 NAD(P) binding site [chemical binding]; other site 1283331003700 active site 1283331003701 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1283331003702 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1283331003703 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1283331003704 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1283331003705 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1283331003706 oligomerisation interface [polypeptide binding]; other site 1283331003707 mobile loop; other site 1283331003708 roof hairpin; other site 1283331003709 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1283331003710 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1283331003711 ring oligomerisation interface [polypeptide binding]; other site 1283331003712 ATP/Mg binding site [chemical binding]; other site 1283331003713 stacking interactions; other site 1283331003714 hinge regions; other site 1283331003715 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1283331003716 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283331003717 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283331003718 putative active site [active] 1283331003719 putative NTP binding site [chemical binding]; other site 1283331003720 putative nucleic acid binding site [nucleotide binding]; other site 1283331003721 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1283331003722 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1283331003723 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1283331003724 active site 1283331003725 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1283331003726 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1283331003727 active site 1283331003728 uracil binding [chemical binding]; other site 1283331003729 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331003730 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331003731 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331003732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331003733 enoyl-CoA hydratase; Provisional; Region: PRK09076 1283331003734 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283331003735 substrate binding site [chemical binding]; other site 1283331003736 oxyanion hole (OAH) forming residues; other site 1283331003737 trimer interface [polypeptide binding]; other site 1283331003738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331003739 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331003740 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331003741 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331003742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331003743 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331003744 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331003745 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1283331003746 ligand binding site [chemical binding]; other site 1283331003747 active site 1283331003748 UGI interface [polypeptide binding]; other site 1283331003749 catalytic site [active] 1283331003750 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1283331003751 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1283331003752 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1283331003753 L-aspartate oxidase; Provisional; Region: PRK09077 1283331003754 L-aspartate oxidase; Provisional; Region: PRK06175 1283331003755 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1283331003756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1283331003757 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1283331003758 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 1283331003759 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1283331003760 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1283331003761 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1283331003762 MucB/RseB family; Region: MucB_RseB; pfam03888 1283331003763 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 1283331003764 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1283331003765 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1283331003766 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1283331003767 protein binding site [polypeptide binding]; other site 1283331003768 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1283331003769 protein binding site [polypeptide binding]; other site 1283331003770 GTP-binding protein LepA; Provisional; Region: PRK05433 1283331003771 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1283331003772 G1 box; other site 1283331003773 putative GEF interaction site [polypeptide binding]; other site 1283331003774 GTP/Mg2+ binding site [chemical binding]; other site 1283331003775 Switch I region; other site 1283331003776 G2 box; other site 1283331003777 G3 box; other site 1283331003778 Switch II region; other site 1283331003779 G4 box; other site 1283331003780 G5 box; other site 1283331003781 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1283331003782 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1283331003783 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1283331003784 signal peptidase I; Provisional; Region: PRK10861 1283331003785 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1283331003786 Catalytic site [active] 1283331003787 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1283331003788 ribonuclease III; Reviewed; Region: rnc; PRK00102 1283331003789 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1283331003790 dimerization interface [polypeptide binding]; other site 1283331003791 active site 1283331003792 metal binding site [ion binding]; metal-binding site 1283331003793 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1283331003794 dsRNA binding site [nucleotide binding]; other site 1283331003795 GTPase Era; Reviewed; Region: era; PRK00089 1283331003796 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1283331003797 G1 box; other site 1283331003798 GTP/Mg2+ binding site [chemical binding]; other site 1283331003799 Switch I region; other site 1283331003800 G2 box; other site 1283331003801 Switch II region; other site 1283331003802 G3 box; other site 1283331003803 G4 box; other site 1283331003804 G5 box; other site 1283331003805 Alginate lyase; Region: Alginate_lyase2; pfam08787 1283331003806 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1283331003807 Recombination protein O N terminal; Region: RecO_N; pfam11967 1283331003808 Recombination protein O C terminal; Region: RecO_C; pfam02565 1283331003809 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1283331003810 active site 1283331003811 hydrophilic channel; other site 1283331003812 dimerization interface [polypeptide binding]; other site 1283331003813 catalytic residues [active] 1283331003814 active site lid [active] 1283331003815 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1283331003816 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1283331003817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331003818 S-adenosylmethionine binding site [chemical binding]; other site 1283331003819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331003820 S-adenosylmethionine binding site [chemical binding]; other site 1283331003821 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1283331003822 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1283331003823 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1283331003824 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283331003825 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1283331003826 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1283331003827 tetrameric interface [polypeptide binding]; other site 1283331003828 NAD binding site [chemical binding]; other site 1283331003829 catalytic residues [active] 1283331003830 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1283331003831 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 1283331003832 putative active site [active] 1283331003833 metal binding site [ion binding]; metal-binding site 1283331003834 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1283331003835 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1283331003836 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1283331003837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331003838 Walker A motif; other site 1283331003839 ATP binding site [chemical binding]; other site 1283331003840 Walker B motif; other site 1283331003841 arginine finger; other site 1283331003842 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1283331003843 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1283331003844 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1283331003845 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 1283331003846 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1283331003847 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1283331003848 Glutamate binding site [chemical binding]; other site 1283331003849 NAD binding site [chemical binding]; other site 1283331003850 catalytic residues [active] 1283331003851 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1283331003852 Transglycosylase; Region: Transgly; cl17702 1283331003853 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1283331003854 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1283331003855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331003856 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1283331003857 putative dimerization interface [polypeptide binding]; other site 1283331003858 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1283331003859 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1283331003860 THF binding site; other site 1283331003861 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1283331003862 substrate binding site [chemical binding]; other site 1283331003863 THF binding site; other site 1283331003864 zinc-binding site [ion binding]; other site 1283331003865 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1283331003866 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283331003867 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1283331003868 putative deacylase active site [active] 1283331003869 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1283331003870 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1283331003871 Walker A/P-loop; other site 1283331003872 ATP binding site [chemical binding]; other site 1283331003873 Q-loop/lid; other site 1283331003874 ABC transporter signature motif; other site 1283331003875 Walker B; other site 1283331003876 D-loop; other site 1283331003877 H-loop/switch region; other site 1283331003878 TOBE domain; Region: TOBE_2; pfam08402 1283331003879 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1283331003880 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1283331003881 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1283331003882 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1283331003883 putative GSH binding site [chemical binding]; other site 1283331003884 catalytic residues [active] 1283331003885 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1283331003886 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1283331003887 heme binding site [chemical binding]; other site 1283331003888 ferroxidase pore; other site 1283331003889 ferroxidase diiron center [ion binding]; other site 1283331003890 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1283331003891 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1283331003892 dimer interface [polypeptide binding]; other site 1283331003893 catalytic site [active] 1283331003894 putative active site [active] 1283331003895 putative substrate binding site [chemical binding]; other site 1283331003896 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1283331003897 active site 1283331003898 substrate binding pocket [chemical binding]; other site 1283331003899 dimer interface [polypeptide binding]; other site 1283331003900 argininosuccinate synthase; Provisional; Region: PRK13820 1283331003901 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1283331003902 ANP binding site [chemical binding]; other site 1283331003903 Substrate Binding Site II [chemical binding]; other site 1283331003904 Substrate Binding Site I [chemical binding]; other site 1283331003905 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1283331003906 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1283331003907 GTP binding site; other site 1283331003908 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1283331003909 MPT binding site; other site 1283331003910 trimer interface [polypeptide binding]; other site 1283331003911 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1283331003912 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1283331003913 dimer interface [polypeptide binding]; other site 1283331003914 putative functional site; other site 1283331003915 putative MPT binding site; other site 1283331003916 lipid kinase; Reviewed; Region: PRK13054 1283331003917 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1283331003918 lytic murein transglycosylase; Provisional; Region: PRK11619 1283331003919 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283331003920 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283331003921 catalytic residue [active] 1283331003922 ABC transporter ATPase component; Reviewed; Region: PRK11147 1283331003923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283331003924 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283331003925 ABC transporter; Region: ABC_tran_2; pfam12848 1283331003926 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283331003927 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331003928 Ligand Binding Site [chemical binding]; other site 1283331003929 benzoate transport; Region: 2A0115; TIGR00895 1283331003930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331003931 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331003932 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1283331003933 active site 1283331003934 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 1283331003935 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283331003936 substrate binding site [chemical binding]; other site 1283331003937 oxyanion hole (OAH) forming residues; other site 1283331003938 trimer interface [polypeptide binding]; other site 1283331003939 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 1283331003940 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283331003941 NAD(P) binding site [chemical binding]; other site 1283331003942 catalytic residues [active] 1283331003943 feruloyl-CoA synthase; Reviewed; Region: PRK08180 1283331003944 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 1283331003945 acyl-activating enzyme (AAE) consensus motif; other site 1283331003946 putative AMP binding site [chemical binding]; other site 1283331003947 putative active site [active] 1283331003948 putative CoA binding site [chemical binding]; other site 1283331003949 putative acyltransferase; Provisional; Region: PRK05790 1283331003950 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283331003951 dimer interface [polypeptide binding]; other site 1283331003952 active site 1283331003953 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1283331003954 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1283331003955 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331003956 active site 1283331003957 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1283331003958 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1283331003959 Ligand binding site [chemical binding]; other site 1283331003960 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1283331003961 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1283331003962 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1283331003963 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331003964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331003965 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331003966 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1283331003967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331003968 active site 1283331003969 phosphorylation site [posttranslational modification] 1283331003970 intermolecular recognition site; other site 1283331003971 dimerization interface [polypeptide binding]; other site 1283331003972 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331003973 DNA binding site [nucleotide binding] 1283331003974 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1283331003975 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331003976 dimerization interface [polypeptide binding]; other site 1283331003977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331003978 dimer interface [polypeptide binding]; other site 1283331003979 phosphorylation site [posttranslational modification] 1283331003980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331003981 ATP binding site [chemical binding]; other site 1283331003982 Mg2+ binding site [ion binding]; other site 1283331003983 G-X-G motif; other site 1283331003984 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1283331003985 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283331003986 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331003987 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1283331003988 Protein export membrane protein; Region: SecD_SecF; cl14618 1283331003989 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1283331003990 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1283331003991 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 1283331003992 Protein of unknown function (DUF2501); Region: DUF2501; cl08197 1283331003993 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1283331003994 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1283331003995 NAD(P) binding site [chemical binding]; other site 1283331003996 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1283331003997 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1283331003998 Cupin domain; Region: Cupin_2; cl17218 1283331003999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331004000 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1283331004001 MarR family; Region: MarR_2; pfam12802 1283331004002 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1283331004003 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283331004004 substrate binding site [chemical binding]; other site 1283331004005 oxyanion hole (OAH) forming residues; other site 1283331004006 trimer interface [polypeptide binding]; other site 1283331004007 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283331004008 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283331004009 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283331004010 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1283331004011 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283331004012 dimer interface [polypeptide binding]; other site 1283331004013 active site 1283331004014 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1283331004015 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1283331004016 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1283331004017 active site 1283331004018 interdomain interaction site; other site 1283331004019 putative metal-binding site [ion binding]; other site 1283331004020 nucleotide binding site [chemical binding]; other site 1283331004021 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1283331004022 domain I; other site 1283331004023 DNA binding groove [nucleotide binding] 1283331004024 phosphate binding site [ion binding]; other site 1283331004025 domain II; other site 1283331004026 domain III; other site 1283331004027 nucleotide binding site [chemical binding]; other site 1283331004028 catalytic site [active] 1283331004029 domain IV; other site 1283331004030 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1283331004031 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1283331004032 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1283331004033 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1283331004034 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 1283331004035 Cell division inhibitor SulA; Region: SulA; cl01880 1283331004036 LexA repressor; Validated; Region: PRK00215 1283331004037 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1283331004038 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1283331004039 Catalytic site [active] 1283331004040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283331004041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331004042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1283331004043 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1283331004044 beta-hexosaminidase; Provisional; Region: PRK05337 1283331004045 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1283331004046 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 1283331004047 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1283331004048 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1283331004049 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1283331004050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283331004051 ATP binding site [chemical binding]; other site 1283331004052 putative Mg++ binding site [ion binding]; other site 1283331004053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331004054 nucleotide binding region [chemical binding]; other site 1283331004055 ATP-binding site [chemical binding]; other site 1283331004056 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1283331004057 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1283331004058 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1283331004059 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1283331004060 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1283331004061 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283331004062 E3 interaction surface; other site 1283331004063 lipoyl attachment site [posttranslational modification]; other site 1283331004064 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1283331004065 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1283331004066 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1283331004067 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1283331004068 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1283331004069 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1283331004070 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1283331004071 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331004072 catalytic loop [active] 1283331004073 iron binding site [ion binding]; other site 1283331004074 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1283331004075 FAD binding pocket [chemical binding]; other site 1283331004076 FAD binding motif [chemical binding]; other site 1283331004077 phosphate binding motif [ion binding]; other site 1283331004078 beta-alpha-beta structure motif; other site 1283331004079 NAD binding pocket [chemical binding]; other site 1283331004080 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1283331004081 ApbE family; Region: ApbE; pfam02424 1283331004082 Protein of unknown function (DUF539); Region: DUF539; cl01129 1283331004083 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1283331004084 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1283331004085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283331004086 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1283331004087 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1283331004088 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1283331004089 active site 1283331004090 catalytic site [active] 1283331004091 metal binding site [ion binding]; metal-binding site 1283331004092 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1283331004093 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1283331004094 FtsX-like permease family; Region: FtsX; pfam02687 1283331004095 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1283331004096 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1283331004097 Walker A/P-loop; other site 1283331004098 ATP binding site [chemical binding]; other site 1283331004099 Q-loop/lid; other site 1283331004100 ABC transporter signature motif; other site 1283331004101 Walker B; other site 1283331004102 D-loop; other site 1283331004103 H-loop/switch region; other site 1283331004104 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1283331004105 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1283331004106 FtsX-like permease family; Region: FtsX; pfam02687 1283331004107 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1283331004108 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1283331004109 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1283331004110 Competence protein; Region: Competence; pfam03772 1283331004111 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1283331004112 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1283331004113 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283331004114 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1283331004115 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1283331004116 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1283331004117 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1283331004118 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1283331004119 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1283331004120 Ligand binding site; other site 1283331004121 oligomer interface; other site 1283331004122 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1283331004123 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1283331004124 active site 1283331004125 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1283331004126 FAD binding domain; Region: FAD_binding_4; pfam01565 1283331004127 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1283331004128 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1283331004129 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1283331004130 homodimer interface [polypeptide binding]; other site 1283331004131 oligonucleotide binding site [chemical binding]; other site 1283331004132 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1283331004133 active site 1283331004134 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1283331004135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331004136 motif II; other site 1283331004137 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1283331004138 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1283331004139 tandem repeat interface [polypeptide binding]; other site 1283331004140 oligomer interface [polypeptide binding]; other site 1283331004141 active site residues [active] 1283331004142 Maf-like protein; Region: Maf; pfam02545 1283331004143 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1283331004144 active site 1283331004145 dimer interface [polypeptide binding]; other site 1283331004146 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1283331004147 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1283331004148 putative phosphate acyltransferase; Provisional; Region: PRK05331 1283331004149 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1283331004150 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1283331004151 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1283331004152 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1283331004153 NAD(P) binding site [chemical binding]; other site 1283331004154 homotetramer interface [polypeptide binding]; other site 1283331004155 homodimer interface [polypeptide binding]; other site 1283331004156 active site 1283331004157 acyl carrier protein; Provisional; Region: acpP; PRK00982 1283331004158 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1283331004159 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1283331004160 dimer interface [polypeptide binding]; other site 1283331004161 active site 1283331004162 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1283331004163 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1283331004164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331004165 catalytic residue [active] 1283331004166 YceG-like family; Region: YceG; pfam02618 1283331004167 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1283331004168 dimerization interface [polypeptide binding]; other site 1283331004169 thymidylate kinase; Validated; Region: tmk; PRK00698 1283331004170 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1283331004171 TMP-binding site; other site 1283331004172 ATP-binding site [chemical binding]; other site 1283331004173 DNA polymerase III subunit delta'; Validated; Region: PRK05707 1283331004174 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1283331004175 PilZ domain; Region: PilZ; cl01260 1283331004176 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1283331004177 active site 1283331004178 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283331004179 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283331004180 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1283331004181 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1283331004182 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283331004183 catalytic residue [active] 1283331004184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 1283331004185 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1283331004186 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1283331004187 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1283331004188 putative active site [active] 1283331004189 Fe(II) binding site [ion binding]; other site 1283331004190 putative dimer interface [polypeptide binding]; other site 1283331004191 putative tetramer interface [polypeptide binding]; other site 1283331004192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331004193 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283331004194 active site 1283331004195 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1283331004196 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1283331004197 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283331004198 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283331004199 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1283331004200 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283331004201 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283331004202 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 1283331004203 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1283331004204 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283331004205 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1283331004206 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1283331004207 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1283331004208 active site 1283331004209 catalytic residues [active] 1283331004210 metal binding site [ion binding]; metal-binding site 1283331004211 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1283331004212 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1283331004213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331004214 putative substrate translocation pore; other site 1283331004215 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331004216 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1283331004217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1283331004218 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1283331004219 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1283331004220 Ligand binding site [chemical binding]; other site 1283331004221 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1283331004222 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1283331004223 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1283331004224 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1283331004225 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1283331004226 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283331004227 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283331004228 ligand binding site [chemical binding]; other site 1283331004229 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 1283331004230 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1283331004231 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1283331004232 active site 1283331004233 dimer interface [polypeptide binding]; other site 1283331004234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 1283331004235 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 1283331004236 elongation factor P; Validated; Region: PRK00529 1283331004237 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1283331004238 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1283331004239 RNA binding site [nucleotide binding]; other site 1283331004240 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1283331004241 RNA binding site [nucleotide binding]; other site 1283331004242 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1283331004243 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1283331004244 MarR family; Region: MarR; pfam01047 1283331004245 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331004246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331004247 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331004248 putative effector binding pocket; other site 1283331004249 dimerization interface [polypeptide binding]; other site 1283331004250 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283331004251 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283331004252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331004253 S-adenosylmethionine binding site [chemical binding]; other site 1283331004254 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1283331004255 helicase 45; Provisional; Region: PTZ00424 1283331004256 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1283331004257 ATP binding site [chemical binding]; other site 1283331004258 Mg++ binding site [ion binding]; other site 1283331004259 motif III; other site 1283331004260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331004261 nucleotide binding region [chemical binding]; other site 1283331004262 ATP-binding site [chemical binding]; other site 1283331004263 DbpA RNA binding domain; Region: DbpA; pfam03880 1283331004264 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 1283331004265 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 1283331004266 heat shock protein HtpX; Provisional; Region: PRK05457 1283331004267 aminotransferase AlaT; Validated; Region: PRK09265 1283331004268 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283331004269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331004270 homodimer interface [polypeptide binding]; other site 1283331004271 catalytic residue [active] 1283331004272 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1283331004273 SelR domain; Region: SelR; pfam01641 1283331004274 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1283331004275 catalytic residues [active] 1283331004276 dimer interface [polypeptide binding]; other site 1283331004277 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1283331004278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331004279 ATP binding site [chemical binding]; other site 1283331004280 Mg2+ binding site [ion binding]; other site 1283331004281 G-X-G motif; other site 1283331004282 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331004283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331004284 active site 1283331004285 phosphorylation site [posttranslational modification] 1283331004286 intermolecular recognition site; other site 1283331004287 dimerization interface [polypeptide binding]; other site 1283331004288 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1283331004289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331004290 Walker A motif; other site 1283331004291 ATP binding site [chemical binding]; other site 1283331004292 Walker B motif; other site 1283331004293 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1283331004294 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1283331004295 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1283331004296 active site 1283331004297 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1283331004298 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1283331004299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331004300 Walker A/P-loop; other site 1283331004301 ATP binding site [chemical binding]; other site 1283331004302 Q-loop/lid; other site 1283331004303 ABC transporter signature motif; other site 1283331004304 Walker B; other site 1283331004305 D-loop; other site 1283331004306 H-loop/switch region; other site 1283331004307 inner membrane transport permease; Provisional; Region: PRK15066 1283331004308 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283331004309 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1283331004310 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331004311 dimerization interface [polypeptide binding]; other site 1283331004312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331004313 dimer interface [polypeptide binding]; other site 1283331004314 phosphorylation site [posttranslational modification] 1283331004315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331004316 ATP binding site [chemical binding]; other site 1283331004317 Mg2+ binding site [ion binding]; other site 1283331004318 G-X-G motif; other site 1283331004319 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1283331004320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331004321 active site 1283331004322 phosphorylation site [posttranslational modification] 1283331004323 intermolecular recognition site; other site 1283331004324 dimerization interface [polypeptide binding]; other site 1283331004325 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331004326 DNA binding site [nucleotide binding] 1283331004327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1283331004328 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1283331004329 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1283331004330 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1283331004331 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1283331004332 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1283331004333 putative FMN binding site [chemical binding]; other site 1283331004334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1283331004335 dimerization interface [polypeptide binding]; other site 1283331004336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331004337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331004338 ATP binding site [chemical binding]; other site 1283331004339 G-X-G motif; other site 1283331004340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283331004341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331004342 active site 1283331004343 phosphorylation site [posttranslational modification] 1283331004344 intermolecular recognition site; other site 1283331004345 dimerization interface [polypeptide binding]; other site 1283331004346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331004347 DNA binding site [nucleotide binding] 1283331004348 YciI-like protein; Reviewed; Region: PRK11370 1283331004349 intracellular septation protein A; Reviewed; Region: PRK00259 1283331004350 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1283331004351 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1283331004352 active site 1283331004353 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1283331004354 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1283331004355 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1283331004356 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1283331004357 phosphogluconate dehydratase; Validated; Region: PRK09054 1283331004358 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1283331004359 glucokinase; Provisional; Region: glk; PRK00292 1283331004360 glucokinase, proteobacterial type; Region: glk; TIGR00749 1283331004361 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1283331004362 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1283331004363 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1283331004364 putative active site [active] 1283331004365 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1283331004366 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1283331004367 putative active site [active] 1283331004368 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1283331004369 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1283331004370 active site 1283331004371 intersubunit interface [polypeptide binding]; other site 1283331004372 catalytic residue [active] 1283331004373 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1283331004374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1283331004375 RNA binding surface [nucleotide binding]; other site 1283331004376 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1283331004377 probable active site [active] 1283331004378 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1283331004379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331004380 NAD(P) binding site [chemical binding]; other site 1283331004381 active site 1283331004382 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1283331004383 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1283331004384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331004385 motif II; other site 1283331004386 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1283331004387 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1283331004388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331004389 S-adenosylmethionine binding site [chemical binding]; other site 1283331004390 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1283331004391 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1283331004392 active site 1283331004393 putative substrate binding pocket [chemical binding]; other site 1283331004394 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1283331004395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1283331004396 Probable transposase; Region: OrfB_IS605; pfam01385 1283331004397 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1283331004398 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283331004399 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331004400 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331004401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283331004402 Integrase core domain; Region: rve; pfam00665 1283331004403 Integrase core domain; Region: rve_3; pfam13683 1283331004404 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1283331004405 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1283331004406 DNA gyrase subunit A; Validated; Region: PRK05560 1283331004407 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1283331004408 CAP-like domain; other site 1283331004409 active site 1283331004410 primary dimer interface [polypeptide binding]; other site 1283331004411 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283331004412 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283331004413 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283331004414 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283331004415 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283331004416 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283331004417 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1283331004418 homodimer interface [polypeptide binding]; other site 1283331004419 substrate-cofactor binding pocket; other site 1283331004420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331004421 catalytic residue [active] 1283331004422 Chorismate mutase type II; Region: CM_2; cl00693 1283331004423 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1283331004424 Prephenate dehydratase; Region: PDT; pfam00800 1283331004425 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1283331004426 putative L-Phe binding site [chemical binding]; other site 1283331004427 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1283331004428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283331004429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331004430 homodimer interface [polypeptide binding]; other site 1283331004431 catalytic residue [active] 1283331004432 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 1283331004433 prephenate dehydrogenase; Validated; Region: PRK08507 1283331004434 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1283331004435 hinge; other site 1283331004436 active site 1283331004437 cytidylate kinase; Provisional; Region: cmk; PRK00023 1283331004438 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1283331004439 CMP-binding site; other site 1283331004440 The sites determining sugar specificity; other site 1283331004441 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1283331004442 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1283331004443 RNA binding site [nucleotide binding]; other site 1283331004444 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1283331004445 RNA binding site [nucleotide binding]; other site 1283331004446 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1283331004447 RNA binding site [nucleotide binding]; other site 1283331004448 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1283331004449 RNA binding site [nucleotide binding]; other site 1283331004450 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1283331004451 RNA binding site [nucleotide binding]; other site 1283331004452 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1283331004453 RNA binding site [nucleotide binding]; other site 1283331004454 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283331004455 IHF dimer interface [polypeptide binding]; other site 1283331004456 IHF - DNA interface [nucleotide binding]; other site 1283331004457 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1283331004458 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1283331004459 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1283331004460 Beta-Casp domain; Region: Beta-Casp; smart01027 1283331004461 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1283331004462 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1283331004463 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1283331004464 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1283331004465 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1283331004466 NAD binding site [chemical binding]; other site 1283331004467 substrate binding site [chemical binding]; other site 1283331004468 homodimer interface [polypeptide binding]; other site 1283331004469 active site 1283331004470 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1283331004471 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1283331004472 NADP binding site [chemical binding]; other site 1283331004473 active site 1283331004474 putative substrate binding site [chemical binding]; other site 1283331004475 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1283331004476 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1283331004477 substrate binding site; other site 1283331004478 tetramer interface; other site 1283331004479 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1283331004480 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1283331004481 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1283331004482 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1283331004483 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1283331004484 Walker A/P-loop; other site 1283331004485 ATP binding site [chemical binding]; other site 1283331004486 Q-loop/lid; other site 1283331004487 ABC transporter signature motif; other site 1283331004488 Walker B; other site 1283331004489 D-loop; other site 1283331004490 H-loop/switch region; other site 1283331004491 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1283331004492 putative carbohydrate binding site [chemical binding]; other site 1283331004493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1283331004494 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1283331004495 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 1283331004496 Probable Catalytic site; other site 1283331004497 metal-binding site 1283331004498 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1283331004499 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1283331004500 Probable Catalytic site; other site 1283331004501 metal-binding site 1283331004502 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 1283331004503 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1283331004504 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1283331004505 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1283331004506 Ligand binding site; other site 1283331004507 Putative Catalytic site; other site 1283331004508 DXD motif; other site 1283331004509 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1283331004510 Transposase IS200 like; Region: Y1_Tnp; cl00848 1283331004511 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1283331004512 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1283331004513 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1283331004514 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1283331004515 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 1283331004516 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1283331004517 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1283331004518 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1283331004519 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1283331004520 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283331004521 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283331004522 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1283331004523 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1283331004524 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1283331004525 Walker A motif; other site 1283331004526 ATP binding site [chemical binding]; other site 1283331004527 Walker B motif; other site 1283331004528 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1283331004529 ligand-binding site [chemical binding]; other site 1283331004530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1283331004531 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1283331004532 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283331004533 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1283331004534 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283331004535 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1283331004536 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1283331004537 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1283331004538 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283331004539 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1283331004540 Walker A/P-loop; other site 1283331004541 ATP binding site [chemical binding]; other site 1283331004542 Q-loop/lid; other site 1283331004543 ABC transporter signature motif; other site 1283331004544 Walker B; other site 1283331004545 D-loop; other site 1283331004546 H-loop/switch region; other site 1283331004547 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1283331004548 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283331004549 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331004550 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1283331004551 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1283331004552 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283331004553 ATP binding site [chemical binding]; other site 1283331004554 putative Mg++ binding site [ion binding]; other site 1283331004555 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331004556 nucleotide binding region [chemical binding]; other site 1283331004557 ATP-binding site [chemical binding]; other site 1283331004558 Helicase associated domain (HA2); Region: HA2; pfam04408 1283331004559 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1283331004560 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1283331004561 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1283331004562 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1283331004563 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1283331004564 MarR family; Region: MarR_2; cl17246 1283331004565 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283331004566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331004567 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1283331004568 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1283331004569 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283331004570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331004571 putative substrate translocation pore; other site 1283331004572 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1283331004573 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283331004574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331004575 beta-ketothiolase; Provisional; Region: PRK09051 1283331004576 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283331004577 dimer interface [polypeptide binding]; other site 1283331004578 active site 1283331004579 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1283331004580 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283331004581 substrate binding site [chemical binding]; other site 1283331004582 oxyanion hole (OAH) forming residues; other site 1283331004583 trimer interface [polypeptide binding]; other site 1283331004584 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283331004585 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283331004586 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283331004587 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1283331004588 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331004589 active site 1283331004590 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1283331004591 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1283331004592 Ligand binding site [chemical binding]; other site 1283331004593 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1283331004594 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1283331004595 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 1283331004596 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1283331004597 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1283331004598 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283331004599 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1283331004600 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1283331004601 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1283331004602 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1283331004603 Integrase core domain; Region: rve_3; pfam13683 1283331004604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331004605 NAD(P) binding site [chemical binding]; other site 1283331004606 active site 1283331004607 LysR family transcriptional regulator; Provisional; Region: PRK14997 1283331004608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331004609 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331004610 putative effector binding pocket; other site 1283331004611 dimerization interface [polypeptide binding]; other site 1283331004612 short chain dehydrogenase; Provisional; Region: PRK06523 1283331004613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331004614 NAD(P) binding site [chemical binding]; other site 1283331004615 active site 1283331004616 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1283331004617 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331004618 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331004619 Transposase; Region: HTH_Tnp_1; cl17663 1283331004620 putative transposase OrfB; Reviewed; Region: PHA02517 1283331004621 HTH-like domain; Region: HTH_21; pfam13276 1283331004622 Integrase core domain; Region: rve; pfam00665 1283331004623 Integrase core domain; Region: rve_3; pfam13683 1283331004624 Transposase domain (DUF772); Region: DUF772; pfam05598 1283331004625 Integrase core domain; Region: rve_3; cl15866 1283331004626 polyol permease family; Region: 2A0118; TIGR00897 1283331004627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331004628 putative substrate translocation pore; other site 1283331004629 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1283331004630 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1283331004631 inhibitor binding site; inhibition site 1283331004632 catalytic Zn binding site [ion binding]; other site 1283331004633 structural Zn binding site [ion binding]; other site 1283331004634 NADP binding site [chemical binding]; other site 1283331004635 tetramer interface [polypeptide binding]; other site 1283331004636 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283331004637 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283331004638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331004639 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1283331004640 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1283331004641 putative substrate binding site [chemical binding]; other site 1283331004642 putative ATP binding site [chemical binding]; other site 1283331004643 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1283331004644 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1283331004645 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1283331004646 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1283331004647 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1283331004648 active site 1283331004649 dimer interface [polypeptide binding]; other site 1283331004650 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1283331004651 dimer interface [polypeptide binding]; other site 1283331004652 active site 1283331004653 Transposase domain (DUF772); Region: DUF772; pfam05598 1283331004654 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283331004655 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283331004656 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1283331004657 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283331004658 trimer interface; other site 1283331004659 sugar binding site [chemical binding]; other site 1283331004660 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1283331004661 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283331004662 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1283331004663 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1283331004664 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283331004665 catalytic residue [active] 1283331004666 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1283331004667 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1283331004668 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1283331004669 transcriptional regulator; Provisional; Region: PRK10632 1283331004670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331004671 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 1283331004672 putative effector binding pocket; other site 1283331004673 putative dimerization interface [polypeptide binding]; other site 1283331004674 short chain dehydrogenase; Provisional; Region: PRK08339 1283331004675 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1283331004676 putative NAD(P) binding site [chemical binding]; other site 1283331004677 putative active site [active] 1283331004678 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1283331004679 putative hydrophobic ligand binding site [chemical binding]; other site 1283331004680 protein interface [polypeptide binding]; other site 1283331004681 gate; other site 1283331004682 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283331004683 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1283331004684 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1283331004685 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283331004686 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1283331004687 Walker A/P-loop; other site 1283331004688 ATP binding site [chemical binding]; other site 1283331004689 Q-loop/lid; other site 1283331004690 ABC transporter signature motif; other site 1283331004691 Walker B; other site 1283331004692 D-loop; other site 1283331004693 H-loop/switch region; other site 1283331004694 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283331004695 Walker A/P-loop; other site 1283331004696 ATP binding site [chemical binding]; other site 1283331004697 Q-loop/lid; other site 1283331004698 ABC transporter signature motif; other site 1283331004699 Walker B; other site 1283331004700 D-loop; other site 1283331004701 H-loop/switch region; other site 1283331004702 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283331004703 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1283331004704 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283331004705 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331004706 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1283331004707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1283331004708 Probable transposase; Region: OrfB_IS605; pfam01385 1283331004709 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1283331004710 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1283331004711 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1283331004712 putative active site [active] 1283331004713 putative FMN binding site [chemical binding]; other site 1283331004714 putative substrate binding site [chemical binding]; other site 1283331004715 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1283331004716 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1283331004717 putative NAD(P) binding site [chemical binding]; other site 1283331004718 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1283331004719 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331004720 substrate binding pocket [chemical binding]; other site 1283331004721 membrane-bound complex binding site; other site 1283331004722 hinge residues; other site 1283331004723 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1283331004724 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1283331004725 active site 1283331004726 nucleophile elbow; other site 1283331004727 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1283331004728 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1283331004729 Protein of unknown function DUF82; Region: DUF82; pfam01927 1283331004730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331004731 NAD(P) binding site [chemical binding]; other site 1283331004732 active site 1283331004733 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1283331004734 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1283331004735 RNA binding surface [nucleotide binding]; other site 1283331004736 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 1283331004737 active site 1283331004738 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1283331004739 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1283331004740 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1283331004741 S1 domain; Region: S1_2; pfam13509 1283331004742 S1 domain; Region: S1_2; pfam13509 1283331004743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283331004744 DNA-binding site [nucleotide binding]; DNA binding site 1283331004745 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1283331004746 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1283331004747 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1283331004748 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1283331004749 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1283331004750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1283331004751 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331004752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331004753 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1283331004754 putative dimerization interface [polypeptide binding]; other site 1283331004755 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1283331004756 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1283331004757 Citrate transporter; Region: CitMHS; pfam03600 1283331004758 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331004759 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331004760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331004761 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1283331004762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1283331004763 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 1283331004764 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1283331004765 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1283331004766 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1283331004767 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 1283331004768 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1283331004769 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187 1283331004770 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1283331004771 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331004772 non-specific DNA binding site [nucleotide binding]; other site 1283331004773 salt bridge; other site 1283331004774 sequence-specific DNA binding site [nucleotide binding]; other site 1283331004775 TPR repeat; Region: TPR_11; pfam13414 1283331004776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1283331004777 TPR motif; other site 1283331004778 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1283331004779 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1283331004780 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1283331004781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283331004782 putative ADP-binding pocket [chemical binding]; other site 1283331004783 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1283331004784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331004785 putative substrate translocation pore; other site 1283331004786 MarR family; Region: MarR_2; pfam12802 1283331004787 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331004788 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1283331004789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331004790 active site 1283331004791 phosphorylation site [posttranslational modification] 1283331004792 intermolecular recognition site; other site 1283331004793 dimerization interface [polypeptide binding]; other site 1283331004794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283331004795 DNA binding residues [nucleotide binding] 1283331004796 dimerization interface [polypeptide binding]; other site 1283331004797 PAS domain S-box; Region: sensory_box; TIGR00229 1283331004798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331004799 putative active site [active] 1283331004800 heme pocket [chemical binding]; other site 1283331004801 Histidine kinase; Region: HisKA_3; pfam07730 1283331004802 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1283331004803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331004804 ATP binding site [chemical binding]; other site 1283331004805 Mg2+ binding site [ion binding]; other site 1283331004806 G-X-G motif; other site 1283331004807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283331004808 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1283331004809 substrate binding site [chemical binding]; other site 1283331004810 oxyanion hole (OAH) forming residues; other site 1283331004811 trimer interface [polypeptide binding]; other site 1283331004812 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283331004813 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283331004814 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283331004815 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1283331004816 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283331004817 dimer interface [polypeptide binding]; other site 1283331004818 active site 1283331004819 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 1283331004820 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283331004821 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283331004822 acyl-activating enzyme (AAE) consensus motif; other site 1283331004823 AMP binding site [chemical binding]; other site 1283331004824 active site 1283331004825 CoA binding site [chemical binding]; other site 1283331004826 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1283331004827 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1283331004828 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331004829 active site 1283331004830 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1283331004831 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1283331004832 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1283331004833 CoenzymeA binding site [chemical binding]; other site 1283331004834 subunit interaction site [polypeptide binding]; other site 1283331004835 PHB binding site; other site 1283331004836 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1283331004837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283331004838 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1283331004839 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283331004840 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1283331004841 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1283331004842 Nucleoside recognition; Region: Gate; pfam07670 1283331004843 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1283331004844 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1283331004845 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 1283331004846 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1283331004847 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1283331004848 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1283331004849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331004850 dimer interface [polypeptide binding]; other site 1283331004851 conserved gate region; other site 1283331004852 ABC-ATPase subunit interface; other site 1283331004853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331004854 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1283331004855 Walker A/P-loop; other site 1283331004856 ATP binding site [chemical binding]; other site 1283331004857 Q-loop/lid; other site 1283331004858 ABC transporter signature motif; other site 1283331004859 Walker B; other site 1283331004860 D-loop; other site 1283331004861 H-loop/switch region; other site 1283331004862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331004863 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1283331004864 substrate binding pocket [chemical binding]; other site 1283331004865 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1283331004866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283331004867 DNA-binding site [nucleotide binding]; DNA binding site 1283331004868 FCD domain; Region: FCD; pfam07729 1283331004869 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1283331004870 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1283331004871 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1283331004872 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1283331004873 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1283331004874 NAD binding site [chemical binding]; other site 1283331004875 homotetramer interface [polypeptide binding]; other site 1283331004876 homodimer interface [polypeptide binding]; other site 1283331004877 substrate binding site [chemical binding]; other site 1283331004878 active site 1283331004879 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1283331004880 PAS fold; Region: PAS; pfam00989 1283331004881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331004882 putative active site [active] 1283331004883 heme pocket [chemical binding]; other site 1283331004884 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283331004885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331004886 Walker B motif; other site 1283331004887 arginine finger; other site 1283331004888 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283331004889 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1283331004890 substrate binding site [chemical binding]; other site 1283331004891 oxyanion hole (OAH) forming residues; other site 1283331004892 trimer interface [polypeptide binding]; other site 1283331004893 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1283331004894 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1283331004895 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1283331004896 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1283331004897 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1283331004898 putative active site [active] 1283331004899 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1283331004900 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1283331004901 active site 1283331004902 dimer interface [polypeptide binding]; other site 1283331004903 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1283331004904 dimer interface [polypeptide binding]; other site 1283331004905 active site 1283331004906 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1283331004907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331004908 putative substrate translocation pore; other site 1283331004909 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1283331004910 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1283331004911 putative substrate binding site [chemical binding]; other site 1283331004912 putative ATP binding site [chemical binding]; other site 1283331004913 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1283331004914 active site 1283331004915 catalytic residues [active] 1283331004916 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283331004917 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283331004918 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331004919 N-terminal plug; other site 1283331004920 ligand-binding site [chemical binding]; other site 1283331004921 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283331004922 FecR protein; Region: FecR; pfam04773 1283331004923 RNA polymerase sigma factor; Provisional; Region: PRK12528 1283331004924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331004925 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1283331004926 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283331004927 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283331004928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331004929 putative substrate translocation pore; other site 1283331004930 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331004931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331004932 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1283331004933 putative dimerization interface [polypeptide binding]; other site 1283331004934 putative effector binding pocket; other site 1283331004935 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1283331004936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331004937 S-adenosylmethionine binding site [chemical binding]; other site 1283331004938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331004939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331004940 dimer interface [polypeptide binding]; other site 1283331004941 phosphorylation site [posttranslational modification] 1283331004942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331004943 ATP binding site [chemical binding]; other site 1283331004944 Mg2+ binding site [ion binding]; other site 1283331004945 G-X-G motif; other site 1283331004946 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283331004947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331004948 active site 1283331004949 phosphorylation site [posttranslational modification] 1283331004950 intermolecular recognition site; other site 1283331004951 dimerization interface [polypeptide binding]; other site 1283331004952 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331004953 DNA binding site [nucleotide binding] 1283331004954 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1283331004955 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1283331004956 catalytic core [active] 1283331004957 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1283331004958 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1283331004959 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1283331004960 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1283331004961 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1283331004962 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1283331004963 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283331004964 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1283331004965 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1283331004966 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1283331004967 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283331004968 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1283331004969 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1283331004970 Predicted deacetylase [General function prediction only]; Region: COG3233 1283331004971 putative active site [active] 1283331004972 putative Zn binding site [ion binding]; other site 1283331004973 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1283331004974 DNA-binding site [nucleotide binding]; DNA binding site 1283331004975 RNA-binding motif; other site 1283331004976 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1283331004977 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331004978 Ligand Binding Site [chemical binding]; other site 1283331004979 O-Antigen ligase; Region: Wzy_C; cl04850 1283331004980 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1283331004981 active site 1283331004982 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1283331004983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283331004984 ATP binding site [chemical binding]; other site 1283331004985 putative Mg++ binding site [ion binding]; other site 1283331004986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331004987 nucleotide binding region [chemical binding]; other site 1283331004988 ATP-binding site [chemical binding]; other site 1283331004989 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1283331004990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331004991 dimer interface [polypeptide binding]; other site 1283331004992 phosphorylation site [posttranslational modification] 1283331004993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331004994 ATP binding site [chemical binding]; other site 1283331004995 Mg2+ binding site [ion binding]; other site 1283331004996 G-X-G motif; other site 1283331004997 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283331004998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331004999 active site 1283331005000 phosphorylation site [posttranslational modification] 1283331005001 intermolecular recognition site; other site 1283331005002 dimerization interface [polypeptide binding]; other site 1283331005003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331005004 Walker A motif; other site 1283331005005 ATP binding site [chemical binding]; other site 1283331005006 Walker B motif; other site 1283331005007 arginine finger; other site 1283331005008 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1283331005009 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331005010 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1283331005011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331005012 putative substrate translocation pore; other site 1283331005013 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1283331005014 apolar tunnel; other site 1283331005015 heme binding site [chemical binding]; other site 1283331005016 dimerization interface [polypeptide binding]; other site 1283331005017 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1283331005018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331005019 Walker A motif; other site 1283331005020 ATP binding site [chemical binding]; other site 1283331005021 Walker B motif; other site 1283331005022 arginine finger; other site 1283331005023 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1283331005024 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1283331005025 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1283331005026 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1283331005027 PhnA protein; Region: PhnA; pfam03831 1283331005028 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331005029 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1283331005030 putative active site [active] 1283331005031 putative catalytic site [active] 1283331005032 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 1283331005033 hypothetical protein; Provisional; Region: PRK12378 1283331005034 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 1283331005035 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1283331005036 hypothetical protein; Provisional; Region: PRK10621 1283331005037 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283331005038 Cell division protein ZapA; Region: ZapA; pfam05164 1283331005039 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1283331005040 Peptidase family U32; Region: Peptidase_U32; pfam01136 1283331005041 Collagenase; Region: DUF3656; pfam12392 1283331005042 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1283331005043 30S subunit binding site; other site 1283331005044 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1283331005045 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1283331005046 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1283331005047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331005048 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331005049 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331005050 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331005051 dimerization interface [polypeptide binding]; other site 1283331005052 putative DNA binding site [nucleotide binding]; other site 1283331005053 putative Zn2+ binding site [ion binding]; other site 1283331005054 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1283331005055 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1283331005056 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1283331005057 FMN binding site [chemical binding]; other site 1283331005058 active site 1283331005059 substrate binding site [chemical binding]; other site 1283331005060 catalytic residue [active] 1283331005061 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1283331005062 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283331005063 NAD(P) binding site [chemical binding]; other site 1283331005064 catalytic residues [active] 1283331005065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283331005066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331005067 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1283331005068 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1283331005069 NADP binding site [chemical binding]; other site 1283331005070 dimer interface [polypeptide binding]; other site 1283331005071 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 1283331005072 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283331005073 IHF dimer interface [polypeptide binding]; other site 1283331005074 IHF - DNA interface [nucleotide binding]; other site 1283331005075 Sodium Bile acid symporter family; Region: SBF; cl17470 1283331005076 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1283331005077 DNA binding residues [nucleotide binding] 1283331005078 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1283331005079 Heavy-metal-associated domain; Region: HMA; pfam00403 1283331005080 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283331005081 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1283331005082 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1283331005083 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1283331005084 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1283331005085 Thermostable hemolysin; Region: T_hemolysin; pfam12261 1283331005086 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1283331005087 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914 1283331005088 acyl-activating enzyme (AAE) consensus motif; other site 1283331005089 putative AMP binding site [chemical binding]; other site 1283331005090 putative active site [active] 1283331005091 putative CoA binding site [chemical binding]; other site 1283331005092 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1283331005093 heme binding pocket [chemical binding]; other site 1283331005094 heme ligand [chemical binding]; other site 1283331005095 short chain dehydrogenase; Provisional; Region: PRK09072 1283331005096 classical (c) SDRs; Region: SDR_c; cd05233 1283331005097 NAD(P) binding site [chemical binding]; other site 1283331005098 active site 1283331005099 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283331005100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331005101 active site 1283331005102 phosphorylation site [posttranslational modification] 1283331005103 intermolecular recognition site; other site 1283331005104 dimerization interface [polypeptide binding]; other site 1283331005105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331005106 DNA binding site [nucleotide binding] 1283331005107 sensor protein QseC; Provisional; Region: PRK10337 1283331005108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1283331005109 dimer interface [polypeptide binding]; other site 1283331005110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331005111 ATP binding site [chemical binding]; other site 1283331005112 Mg2+ binding site [ion binding]; other site 1283331005113 G-X-G motif; other site 1283331005114 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1283331005115 hypothetical protein; Provisional; Region: PRK00295 1283331005116 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1283331005117 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1283331005118 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1283331005119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331005120 dimer interface [polypeptide binding]; other site 1283331005121 conserved gate region; other site 1283331005122 putative PBP binding loops; other site 1283331005123 ABC-ATPase subunit interface; other site 1283331005124 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1283331005125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331005126 dimer interface [polypeptide binding]; other site 1283331005127 conserved gate region; other site 1283331005128 putative PBP binding loops; other site 1283331005129 ABC-ATPase subunit interface; other site 1283331005130 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1283331005131 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283331005132 Walker A/P-loop; other site 1283331005133 ATP binding site [chemical binding]; other site 1283331005134 Q-loop/lid; other site 1283331005135 ABC transporter signature motif; other site 1283331005136 Walker B; other site 1283331005137 D-loop; other site 1283331005138 H-loop/switch region; other site 1283331005139 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283331005140 Walker A/P-loop; other site 1283331005141 ATP binding site [chemical binding]; other site 1283331005142 Q-loop/lid; other site 1283331005143 ABC transporter signature motif; other site 1283331005144 Walker B; other site 1283331005145 D-loop; other site 1283331005146 H-loop/switch region; other site 1283331005147 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1283331005148 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 1283331005149 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1283331005150 aminopeptidase N; Provisional; Region: pepN; PRK14015 1283331005151 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1283331005152 active site 1283331005153 Zn binding site [ion binding]; other site 1283331005154 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1283331005155 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1283331005156 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1283331005157 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283331005158 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283331005159 putative active site [active] 1283331005160 putative NTP binding site [chemical binding]; other site 1283331005161 putative nucleic acid binding site [nucleotide binding]; other site 1283331005162 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1283331005163 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 1283331005164 Oxygen tolerance; Region: BatD; pfam13584 1283331005165 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1283331005166 metal ion-dependent adhesion site (MIDAS); other site 1283331005167 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1283331005168 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1283331005169 metal ion-dependent adhesion site (MIDAS); other site 1283331005170 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1283331005171 Protein of unknown function DUF58; Region: DUF58; pfam01882 1283331005172 MoxR-like ATPases [General function prediction only]; Region: COG0714 1283331005173 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 1283331005174 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1283331005175 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1283331005176 Predicted integral membrane protein [Function unknown]; Region: COG0392 1283331005177 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1283331005178 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1283331005179 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1283331005180 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 1283331005181 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283331005182 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283331005183 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283331005184 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1283331005185 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1283331005186 quinone interaction residues [chemical binding]; other site 1283331005187 active site 1283331005188 catalytic residues [active] 1283331005189 FMN binding site [chemical binding]; other site 1283331005190 substrate binding site [chemical binding]; other site 1283331005191 Ribosome modulation factor; Region: RMF; cl01207 1283331005192 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1283331005193 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1283331005194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1283331005195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331005196 S-adenosylmethionine binding site [chemical binding]; other site 1283331005197 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1283331005198 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1283331005199 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1283331005200 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283331005201 Zn2+ binding site [ion binding]; other site 1283331005202 Mg2+ binding site [ion binding]; other site 1283331005203 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1283331005204 Predicted membrane protein [Function unknown]; Region: COG5393 1283331005205 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1283331005206 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1283331005207 Staphylococcal nuclease homologues; Region: SNc; smart00318 1283331005208 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1283331005209 Catalytic site; other site 1283331005210 Dienelactone hydrolase family; Region: DLH; pfam01738 1283331005211 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331005212 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1283331005213 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1283331005214 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1283331005215 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1283331005216 substrate binding site [chemical binding]; other site 1283331005217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331005218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331005219 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1283331005220 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1283331005221 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283331005222 helicase 45; Provisional; Region: PTZ00424 1283331005223 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1283331005224 ATP binding site [chemical binding]; other site 1283331005225 Mg++ binding site [ion binding]; other site 1283331005226 motif III; other site 1283331005227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331005228 nucleotide binding region [chemical binding]; other site 1283331005229 ATP-binding site [chemical binding]; other site 1283331005230 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1283331005231 Methyltransferase domain; Region: Methyltransf_25; pfam13649 1283331005232 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1283331005233 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1283331005234 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1283331005235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283331005236 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1283331005237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331005238 Walker A/P-loop; other site 1283331005239 ATP binding site [chemical binding]; other site 1283331005240 Q-loop/lid; other site 1283331005241 ABC transporter signature motif; other site 1283331005242 Walker B; other site 1283331005243 D-loop; other site 1283331005244 H-loop/switch region; other site 1283331005245 LysR family transcriptional regulator; Provisional; Region: PRK14997 1283331005246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331005247 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331005248 dimerization interface [polypeptide binding]; other site 1283331005249 heat shock protein 90; Provisional; Region: PRK05218 1283331005250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331005251 ATP binding site [chemical binding]; other site 1283331005252 Mg2+ binding site [ion binding]; other site 1283331005253 G-X-G motif; other site 1283331005254 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283331005255 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1283331005256 dimer interface [polypeptide binding]; other site 1283331005257 active site 1283331005258 metal binding site [ion binding]; metal-binding site 1283331005259 glutathione binding site [chemical binding]; other site 1283331005260 endonuclease III; Provisional; Region: PRK10702 1283331005261 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1283331005262 minor groove reading motif; other site 1283331005263 helix-hairpin-helix signature motif; other site 1283331005264 substrate binding pocket [chemical binding]; other site 1283331005265 active site 1283331005266 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1283331005267 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1283331005268 FMN-binding domain; Region: FMN_bind; cl01081 1283331005269 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1283331005270 electron transport complex protein RnfC; Provisional; Region: PRK05035 1283331005271 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1283331005272 SLBB domain; Region: SLBB; pfam10531 1283331005273 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283331005274 ferredoxin; Provisional; Region: PRK08764 1283331005275 Putative Fe-S cluster; Region: FeS; cl17515 1283331005276 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1283331005277 electron transport complex protein RsxA; Provisional; Region: PRK05151 1283331005278 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1283331005279 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1283331005280 active site 1283331005281 HIGH motif; other site 1283331005282 KMSKS motif; other site 1283331005283 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1283331005284 tRNA binding surface [nucleotide binding]; other site 1283331005285 anticodon binding site; other site 1283331005286 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1283331005287 dimer interface [polypeptide binding]; other site 1283331005288 putative tRNA-binding site [nucleotide binding]; other site 1283331005289 antiporter inner membrane protein; Provisional; Region: PRK11670 1283331005290 Domain of unknown function DUF59; Region: DUF59; pfam01883 1283331005291 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1283331005292 Walker A motif; other site 1283331005293 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1283331005294 trimer interface [polypeptide binding]; other site 1283331005295 active site 1283331005296 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331005297 active site 1283331005298 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1283331005299 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1283331005300 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1283331005301 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1283331005302 active site 1283331005303 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 1283331005304 Water Stress and Hypersensitive response; Region: WHy; smart00769 1283331005305 hypothetical protein; Provisional; Region: PRK00183 1283331005306 SEC-C motif; Region: SEC-C; pfam02810 1283331005307 SEC-C motif; Region: SEC-C; pfam02810 1283331005308 Predicted integral membrane protein [Function unknown]; Region: COG5615 1283331005309 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1283331005310 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1283331005311 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1283331005312 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1283331005313 Beta-lactamase; Region: Beta-lactamase; pfam00144 1283331005314 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283331005315 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283331005316 ligand binding site [chemical binding]; other site 1283331005317 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1283331005318 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1283331005319 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1283331005320 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1283331005321 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1283331005322 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283331005323 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1283331005324 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1283331005325 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1283331005326 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1283331005327 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283331005328 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1283331005329 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1283331005330 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1283331005331 Predicted membrane protein [Function unknown]; Region: COG3650 1283331005332 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1283331005333 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1283331005334 Walker A/P-loop; other site 1283331005335 ATP binding site [chemical binding]; other site 1283331005336 Q-loop/lid; other site 1283331005337 ABC transporter signature motif; other site 1283331005338 Walker B; other site 1283331005339 D-loop; other site 1283331005340 H-loop/switch region; other site 1283331005341 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1283331005342 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1283331005343 Walker A/P-loop; other site 1283331005344 ATP binding site [chemical binding]; other site 1283331005345 Q-loop/lid; other site 1283331005346 ABC transporter signature motif; other site 1283331005347 Walker B; other site 1283331005348 D-loop; other site 1283331005349 H-loop/switch region; other site 1283331005350 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1283331005351 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1283331005352 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1283331005353 TM-ABC transporter signature motif; other site 1283331005354 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283331005355 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1283331005356 TM-ABC transporter signature motif; other site 1283331005357 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1283331005358 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1283331005359 dimerization interface [polypeptide binding]; other site 1283331005360 ligand binding site [chemical binding]; other site 1283331005361 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1283331005362 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 1283331005363 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1283331005364 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1283331005365 alpha subunit interaction interface [polypeptide binding]; other site 1283331005366 Walker A motif; other site 1283331005367 ATP binding site [chemical binding]; other site 1283331005368 Walker B motif; other site 1283331005369 inhibitor binding site; inhibition site 1283331005370 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1283331005371 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 1283331005372 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1283331005373 gamma subunit interface [polypeptide binding]; other site 1283331005374 epsilon subunit interface [polypeptide binding]; other site 1283331005375 LBP interface [polypeptide binding]; other site 1283331005376 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 1283331005377 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1283331005378 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 1283331005379 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1283331005380 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1283331005381 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 1283331005382 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1283331005383 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1283331005384 Walker A motif; other site 1283331005385 ATP binding site [chemical binding]; other site 1283331005386 Walker B motif; other site 1283331005387 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1283331005388 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1283331005389 delta subunit interface [polypeptide binding]; other site 1283331005390 core domain interface [polypeptide binding]; other site 1283331005391 epsilon subunit interface [polypeptide binding]; other site 1283331005392 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1283331005393 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1283331005394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331005395 dimer interface [polypeptide binding]; other site 1283331005396 conserved gate region; other site 1283331005397 putative PBP binding loops; other site 1283331005398 ABC-ATPase subunit interface; other site 1283331005399 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1283331005400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331005401 Walker A/P-loop; other site 1283331005402 ATP binding site [chemical binding]; other site 1283331005403 Q-loop/lid; other site 1283331005404 ABC transporter signature motif; other site 1283331005405 Walker B; other site 1283331005406 D-loop; other site 1283331005407 H-loop/switch region; other site 1283331005408 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1283331005409 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1283331005410 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1283331005411 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1283331005412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331005413 Walker A motif; other site 1283331005414 ATP binding site [chemical binding]; other site 1283331005415 Walker B motif; other site 1283331005416 arginine finger; other site 1283331005417 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1283331005418 hypothetical protein; Validated; Region: PRK00153 1283331005419 recombination protein RecR; Reviewed; Region: recR; PRK00076 1283331005420 RecR protein; Region: RecR; pfam02132 1283331005421 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1283331005422 putative active site [active] 1283331005423 putative metal-binding site [ion binding]; other site 1283331005424 tetramer interface [polypeptide binding]; other site 1283331005425 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600 1283331005426 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1283331005427 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1283331005428 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1283331005429 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1283331005430 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1283331005431 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1283331005432 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1283331005433 ligand binding site [chemical binding]; other site 1283331005434 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1283331005435 putative switch regulator; other site 1283331005436 non-specific DNA interactions [nucleotide binding]; other site 1283331005437 DNA binding site [nucleotide binding] 1283331005438 sequence specific DNA binding site [nucleotide binding]; other site 1283331005439 putative cAMP binding site [chemical binding]; other site 1283331005440 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1283331005441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331005442 FeS/SAM binding site; other site 1283331005443 HemN C-terminal domain; Region: HemN_C; pfam06969 1283331005444 Uncharacterized conserved protein [Function unknown]; Region: COG2836 1283331005445 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1283331005446 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1283331005447 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1283331005448 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1283331005449 metal-binding site [ion binding] 1283331005450 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283331005451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331005452 motif II; other site 1283331005453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1283331005454 FixH; Region: FixH; pfam05751 1283331005455 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1283331005456 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1283331005457 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1283331005458 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1283331005459 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1283331005460 Cytochrome c; Region: Cytochrom_C; pfam00034 1283331005461 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1283331005462 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1283331005463 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1283331005464 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1283331005465 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1283331005466 Low-spin heme binding site [chemical binding]; other site 1283331005467 Putative water exit pathway; other site 1283331005468 Binuclear center (active site) [active] 1283331005469 Putative proton exit pathway; other site 1283331005470 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1283331005471 aconitate hydratase; Validated; Region: PRK09277 1283331005472 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1283331005473 substrate binding site [chemical binding]; other site 1283331005474 ligand binding site [chemical binding]; other site 1283331005475 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1283331005476 substrate binding site [chemical binding]; other site 1283331005477 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1283331005478 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1283331005479 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1283331005480 CPxP motif; other site 1283331005481 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1283331005482 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1283331005483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283331005484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331005485 homodimer interface [polypeptide binding]; other site 1283331005486 catalytic residue [active] 1283331005487 excinuclease ABC subunit B; Provisional; Region: PRK05298 1283331005488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283331005489 ATP binding site [chemical binding]; other site 1283331005490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331005491 nucleotide binding region [chemical binding]; other site 1283331005492 ATP-binding site [chemical binding]; other site 1283331005493 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1283331005494 UvrB/uvrC motif; Region: UVR; pfam02151 1283331005495 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1283331005496 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1283331005497 HIGH motif; other site 1283331005498 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1283331005499 active site 1283331005500 KMSKS motif; other site 1283331005501 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1283331005502 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1283331005503 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1283331005504 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1283331005505 tetramer interface [polypeptide binding]; other site 1283331005506 active site 1283331005507 Mg2+/Mn2+ binding site [ion binding]; other site 1283331005508 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1283331005509 metal binding site [ion binding]; metal-binding site 1283331005510 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1283331005511 putative active site [active] 1283331005512 putative metal binding site [ion binding]; other site 1283331005513 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1283331005514 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1283331005515 probable active site [active] 1283331005516 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1283331005517 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1283331005518 putative dimer interface [polypeptide binding]; other site 1283331005519 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1283331005520 active site 1283331005521 nucleophile elbow; other site 1283331005522 Patatin phospholipase; Region: DUF3734; pfam12536 1283331005523 short chain dehydrogenase; Provisional; Region: PRK07326 1283331005524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331005525 NAD(P) binding site [chemical binding]; other site 1283331005526 active site 1283331005527 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1283331005528 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283331005529 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283331005530 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1283331005531 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1283331005532 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1283331005533 shikimate binding site; other site 1283331005534 NAD(P) binding site [chemical binding]; other site 1283331005535 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 1283331005536 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283331005537 NIPSNAP; Region: NIPSNAP; pfam07978 1283331005538 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 1283331005539 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283331005540 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1283331005541 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283331005542 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283331005543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331005544 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1283331005545 L-idonate 5-dehydrogenase; Region: PLN02702 1283331005546 inhibitor binding site; inhibition site 1283331005547 catalytic Zn binding site [ion binding]; other site 1283331005548 structural Zn binding site [ion binding]; other site 1283331005549 NADP binding site [chemical binding]; other site 1283331005550 tetramer interface [polypeptide binding]; other site 1283331005551 polyol permease family; Region: 2A0118; TIGR00897 1283331005552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331005553 putative substrate translocation pore; other site 1283331005554 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1283331005555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331005556 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283331005557 classical (c) SDRs; Region: SDR_c; cd05233 1283331005558 NAD(P) binding site [chemical binding]; other site 1283331005559 active site 1283331005560 putative succinate dehydrogenase; Reviewed; Region: PRK12842 1283331005561 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283331005562 NIPSNAP; Region: NIPSNAP; pfam07978 1283331005563 benzoate transport; Region: 2A0115; TIGR00895 1283331005564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331005565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331005566 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1283331005567 putative active site [active] 1283331005568 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1283331005569 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1283331005570 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1283331005571 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283331005572 putative NTP binding site [chemical binding]; other site 1283331005573 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1283331005574 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1283331005575 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1283331005576 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1283331005577 active site 1283331005578 dimer interface [polypeptide binding]; other site 1283331005579 motif 1; other site 1283331005580 motif 2; other site 1283331005581 motif 3; other site 1283331005582 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1283331005583 anticodon binding site; other site 1283331005584 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1283331005585 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1283331005586 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1283331005587 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1283331005588 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1283331005589 23S rRNA binding site [nucleotide binding]; other site 1283331005590 L21 binding site [polypeptide binding]; other site 1283331005591 L13 binding site [polypeptide binding]; other site 1283331005592 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1283331005593 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1283331005594 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1283331005595 dimer interface [polypeptide binding]; other site 1283331005596 motif 1; other site 1283331005597 active site 1283331005598 motif 2; other site 1283331005599 motif 3; other site 1283331005600 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1283331005601 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1283331005602 putative tRNA-binding site [nucleotide binding]; other site 1283331005603 B3/4 domain; Region: B3_4; pfam03483 1283331005604 tRNA synthetase B5 domain; Region: B5; smart00874 1283331005605 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1283331005606 dimer interface [polypeptide binding]; other site 1283331005607 motif 1; other site 1283331005608 motif 3; other site 1283331005609 motif 2; other site 1283331005610 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1283331005611 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283331005612 IHF dimer interface [polypeptide binding]; other site 1283331005613 IHF - DNA interface [nucleotide binding]; other site 1283331005614 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1283331005615 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1283331005616 active site 1283331005617 DNA binding site [nucleotide binding] 1283331005618 Int/Topo IB signature motif; other site 1283331005619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331005620 non-specific DNA binding site [nucleotide binding]; other site 1283331005621 salt bridge; other site 1283331005622 sequence-specific DNA binding site [nucleotide binding]; other site 1283331005623 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1283331005624 putative transposase OrfB; Reviewed; Region: PHA02517 1283331005625 HTH-like domain; Region: HTH_21; pfam13276 1283331005626 Integrase core domain; Region: rve; pfam00665 1283331005627 Integrase core domain; Region: rve_3; pfam13683 1283331005628 Transposase; Region: HTH_Tnp_1; cl17663 1283331005629 VacJ like lipoprotein; Region: VacJ; cl01073 1283331005630 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1283331005631 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1283331005632 TPP-binding site; other site 1283331005633 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1283331005634 PYR/PP interface [polypeptide binding]; other site 1283331005635 dimer interface [polypeptide binding]; other site 1283331005636 TPP binding site [chemical binding]; other site 1283331005637 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283331005638 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1283331005639 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1283331005640 substrate binding pocket [chemical binding]; other site 1283331005641 chain length determination region; other site 1283331005642 substrate-Mg2+ binding site; other site 1283331005643 catalytic residues [active] 1283331005644 aspartate-rich region 1; other site 1283331005645 active site lid residues [active] 1283331005646 aspartate-rich region 2; other site 1283331005647 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1283331005648 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1283331005649 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1283331005650 active site 1283331005651 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1283331005652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331005653 FeS/SAM binding site; other site 1283331005654 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1283331005655 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1283331005656 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1283331005657 active site 1283331005658 metal binding site [ion binding]; metal-binding site 1283331005659 nudix motif; other site 1283331005660 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 1283331005661 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 1283331005662 ligand binding site; other site 1283331005663 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 1283331005664 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1283331005665 B12 binding site [chemical binding]; other site 1283331005666 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331005667 FeS/SAM binding site; other site 1283331005668 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 1283331005669 putative homodimer interface [polypeptide binding]; other site 1283331005670 putative active site [active] 1283331005671 YdjC motif; other site 1283331005672 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1283331005673 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331005674 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331005675 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1283331005676 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1283331005677 putative NADP binding site [chemical binding]; other site 1283331005678 putative substrate binding site [chemical binding]; other site 1283331005679 active site 1283331005680 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1283331005681 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1283331005682 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1283331005683 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1283331005684 Active site cavity [active] 1283331005685 catalytic acid [active] 1283331005686 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1283331005687 active site lid residues [active] 1283331005688 substrate binding pocket [chemical binding]; other site 1283331005689 catalytic residues [active] 1283331005690 substrate-Mg2+ binding site; other site 1283331005691 aspartate-rich region 1; other site 1283331005692 aspartate-rich region 2; other site 1283331005693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331005694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331005695 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 1283331005696 putative substrate binding pocket [chemical binding]; other site 1283331005697 putative dimerization interface [polypeptide binding]; other site 1283331005698 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1283331005699 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283331005700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331005701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331005702 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331005703 dimerization interface [polypeptide binding]; other site 1283331005704 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1283331005705 active site 1283331005706 catalytic triad [active] 1283331005707 oxyanion hole [active] 1283331005708 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1283331005709 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1283331005710 FMN binding site [chemical binding]; other site 1283331005711 active site 1283331005712 substrate binding site [chemical binding]; other site 1283331005713 catalytic residue [active] 1283331005714 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283331005715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331005716 putative substrate translocation pore; other site 1283331005717 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1283331005718 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 1283331005719 TPR repeat; Region: TPR_11; pfam13414 1283331005720 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 1283331005721 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1283331005722 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1283331005723 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1283331005724 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1283331005725 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1283331005726 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 1283331005727 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 1283331005728 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1283331005729 GAF domain; Region: GAF; pfam01590 1283331005730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331005731 Walker A motif; other site 1283331005732 ATP binding site [chemical binding]; other site 1283331005733 Walker B motif; other site 1283331005734 arginine finger; other site 1283331005735 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331005736 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1283331005737 Protein phosphatase 2C; Region: PP2C; pfam00481 1283331005738 active site 1283331005739 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1283331005740 active site residue [active] 1283331005741 serine O-acetyltransferase; Region: cysE; TIGR01172 1283331005742 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1283331005743 trimer interface [polypeptide binding]; other site 1283331005744 active site 1283331005745 substrate binding site [chemical binding]; other site 1283331005746 CoA binding site [chemical binding]; other site 1283331005747 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1283331005748 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1283331005749 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283331005750 catalytic residue [active] 1283331005751 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1283331005752 metal-binding site [ion binding] 1283331005753 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1283331005754 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1283331005755 metal-binding site [ion binding] 1283331005756 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283331005757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331005758 motif II; other site 1283331005759 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283331005760 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331005761 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331005762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283331005763 Integrase core domain; Region: rve; pfam00665 1283331005764 Integrase core domain; Region: rve_3; pfam13683 1283331005765 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1283331005766 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283331005767 substrate binding site [chemical binding]; other site 1283331005768 oxyanion hole (OAH) forming residues; other site 1283331005769 trimer interface [polypeptide binding]; other site 1283331005770 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1283331005771 Predicted membrane protein [Function unknown]; Region: COG3748 1283331005772 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1283331005773 Cytochrome c; Region: Cytochrom_C; pfam00034 1283331005774 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1283331005775 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1283331005776 allantoicase; Provisional; Region: PRK13257 1283331005777 Allantoicase repeat; Region: Allantoicase; pfam03561 1283331005778 Allantoicase repeat; Region: Allantoicase; pfam03561 1283331005779 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1283331005780 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1283331005781 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1283331005782 active site 1283331005783 catalytic site [active] 1283331005784 tetramer interface [polypeptide binding]; other site 1283331005785 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1283331005786 active site 1283331005787 homotetramer interface [polypeptide binding]; other site 1283331005788 Condensation domain; Region: Condensation; pfam00668 1283331005789 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283331005790 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1283331005791 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1283331005792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331005793 NAD(P) binding site [chemical binding]; other site 1283331005794 active site 1283331005795 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1283331005796 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283331005797 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331005798 acyl-activating enzyme (AAE) consensus motif; other site 1283331005799 AMP binding site [chemical binding]; other site 1283331005800 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331005801 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1283331005802 Isochorismatase family; Region: Isochorismatase; pfam00857 1283331005803 active site 1283331005804 hydrophobic substrate binding pocket; other site 1283331005805 conserved cis-peptide bond; other site 1283331005806 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1283331005807 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1283331005808 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1283331005809 acyl-activating enzyme (AAE) consensus motif; other site 1283331005810 active site 1283331005811 AMP binding site [chemical binding]; other site 1283331005812 substrate binding site [chemical binding]; other site 1283331005813 isochorismate synthase DhbC; Validated; Region: PRK06923 1283331005814 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1283331005815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331005816 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283331005817 putative substrate translocation pore; other site 1283331005818 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1283331005819 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1283331005820 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1283331005821 tetramer interface [polypeptide binding]; other site 1283331005822 active site 1283331005823 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1283331005824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1283331005825 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331005826 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1283331005827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331005828 Walker A/P-loop; other site 1283331005829 ATP binding site [chemical binding]; other site 1283331005830 Q-loop/lid; other site 1283331005831 ABC transporter signature motif; other site 1283331005832 Walker B; other site 1283331005833 D-loop; other site 1283331005834 H-loop/switch region; other site 1283331005835 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1283331005836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331005837 dimer interface [polypeptide binding]; other site 1283331005838 conserved gate region; other site 1283331005839 putative PBP binding loops; other site 1283331005840 ABC-ATPase subunit interface; other site 1283331005841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331005842 dimer interface [polypeptide binding]; other site 1283331005843 conserved gate region; other site 1283331005844 putative PBP binding loops; other site 1283331005845 ABC-ATPase subunit interface; other site 1283331005846 hypothetical protein; Validated; Region: PRK07121 1283331005847 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283331005848 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283331005849 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1283331005850 active site 1283331005851 iron coordination sites [ion binding]; other site 1283331005852 substrate binding pocket [chemical binding]; other site 1283331005853 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283331005854 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331005855 active site 1283331005856 non-prolyl cis peptide bond; other site 1283331005857 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1283331005858 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1283331005859 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1283331005860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331005861 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1283331005862 putative dimerization interface [polypeptide binding]; other site 1283331005863 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1283331005864 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331005865 substrate binding pocket [chemical binding]; other site 1283331005866 membrane-bound complex binding site; other site 1283331005867 hinge residues; other site 1283331005868 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1283331005869 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1283331005870 FAD binding domain; Region: FAD_binding_4; pfam01565 1283331005871 aspartate aminotransferase; Provisional; Region: PRK06107 1283331005872 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283331005873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331005874 homodimer interface [polypeptide binding]; other site 1283331005875 catalytic residue [active] 1283331005876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331005877 dimer interface [polypeptide binding]; other site 1283331005878 conserved gate region; other site 1283331005879 putative PBP binding loops; other site 1283331005880 ABC-ATPase subunit interface; other site 1283331005881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331005882 dimer interface [polypeptide binding]; other site 1283331005883 conserved gate region; other site 1283331005884 putative PBP binding loops; other site 1283331005885 ABC-ATPase subunit interface; other site 1283331005886 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1283331005887 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1283331005888 Walker A/P-loop; other site 1283331005889 ATP binding site [chemical binding]; other site 1283331005890 Q-loop/lid; other site 1283331005891 ABC transporter signature motif; other site 1283331005892 Walker B; other site 1283331005893 D-loop; other site 1283331005894 H-loop/switch region; other site 1283331005895 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1283331005896 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1283331005897 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1283331005898 C-terminal domain interface [polypeptide binding]; other site 1283331005899 GSH binding site (G-site) [chemical binding]; other site 1283331005900 dimer interface [polypeptide binding]; other site 1283331005901 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1283331005902 N-terminal domain interface [polypeptide binding]; other site 1283331005903 dimer interface [polypeptide binding]; other site 1283331005904 substrate binding pocket (H-site) [chemical binding]; other site 1283331005905 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1283331005906 active site residue [active] 1283331005907 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1283331005908 active site residue [active] 1283331005909 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1283331005910 active site residue [active] 1283331005911 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1283331005912 active site residue [active] 1283331005913 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1283331005914 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1283331005915 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283331005916 catalytic residue [active] 1283331005917 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283331005918 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283331005919 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331005920 N-terminal plug; other site 1283331005921 ligand-binding site [chemical binding]; other site 1283331005922 fec operon regulator FecR; Reviewed; Region: PRK09774 1283331005923 FecR protein; Region: FecR; pfam04773 1283331005924 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1283331005925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331005926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331005927 DNA binding residues [nucleotide binding] 1283331005928 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1283331005929 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283331005930 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1283331005931 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180 1283331005932 putative ligand binding site [chemical binding]; other site 1283331005933 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1283331005934 putative NAD binding site [chemical binding]; other site 1283331005935 catalytic site [active] 1283331005936 aldolase II superfamily protein; Provisional; Region: PRK07044 1283331005937 intersubunit interface [polypeptide binding]; other site 1283331005938 active site 1283331005939 Zn2+ binding site [ion binding]; other site 1283331005940 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283331005941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331005942 dimer interface [polypeptide binding]; other site 1283331005943 conserved gate region; other site 1283331005944 putative PBP binding loops; other site 1283331005945 ABC-ATPase subunit interface; other site 1283331005946 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283331005947 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283331005948 Walker A/P-loop; other site 1283331005949 ATP binding site [chemical binding]; other site 1283331005950 Q-loop/lid; other site 1283331005951 ABC transporter signature motif; other site 1283331005952 Walker B; other site 1283331005953 D-loop; other site 1283331005954 H-loop/switch region; other site 1283331005955 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1283331005956 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331005957 N-terminal plug; other site 1283331005958 ligand-binding site [chemical binding]; other site 1283331005959 NMT1/THI5 like; Region: NMT1; pfam09084 1283331005960 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331005961 membrane-bound complex binding site; other site 1283331005962 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283331005963 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331005964 active site 1283331005965 non-prolyl cis peptide bond; other site 1283331005966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331005967 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331005968 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283331005969 dimerization interface [polypeptide binding]; other site 1283331005970 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283331005971 TolR protein; Region: tolR; TIGR02801 1283331005972 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1283331005973 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1283331005974 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283331005975 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331005976 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331005977 substrate binding pocket [chemical binding]; other site 1283331005978 membrane-bound complex binding site; other site 1283331005979 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331005980 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331005981 active site 1283331005982 catalytic tetrad [active] 1283331005983 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283331005984 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331005985 active site 1283331005986 non-prolyl cis peptide bond; other site 1283331005987 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331005988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331005989 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283331005990 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283331005991 DNA binding site [nucleotide binding] 1283331005992 domain linker motif; other site 1283331005993 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1283331005994 putative ligand binding site [chemical binding]; other site 1283331005995 putative dimerization interface [polypeptide binding]; other site 1283331005996 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1283331005997 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1283331005998 RES domain; Region: RES; smart00953 1283331005999 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283331006000 TolR protein; Region: tolR; TIGR02801 1283331006001 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1283331006002 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1283331006003 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283331006004 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283331006005 active site 1283331006006 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1283331006007 dimer interface [polypeptide binding]; other site 1283331006008 non-prolyl cis peptide bond; other site 1283331006009 insertion regions; other site 1283331006010 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1283331006011 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283331006012 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283331006013 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1283331006014 putative catalytic residues [active] 1283331006015 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283331006016 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331006017 active site 1283331006018 non-prolyl cis peptide bond; other site 1283331006019 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1283331006020 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1283331006021 FMN binding site [chemical binding]; other site 1283331006022 active site 1283331006023 substrate binding site [chemical binding]; other site 1283331006024 catalytic residue [active] 1283331006025 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331006026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331006027 membrane-bound complex binding site; other site 1283331006028 Ferredoxin [Energy production and conversion]; Region: COG1146 1283331006029 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1283331006030 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1283331006031 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1283331006032 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1283331006033 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1283331006034 molybdopterin cofactor binding site [chemical binding]; other site 1283331006035 substrate binding site [chemical binding]; other site 1283331006036 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1283331006037 molybdopterin cofactor binding site; other site 1283331006038 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283331006039 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283331006040 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283331006041 substrate binding pocket [chemical binding]; other site 1283331006042 active site 1283331006043 iron coordination sites [ion binding]; other site 1283331006044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283331006045 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331006046 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283331006047 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283331006048 Walker A/P-loop; other site 1283331006049 ATP binding site [chemical binding]; other site 1283331006050 Q-loop/lid; other site 1283331006051 ABC transporter signature motif; other site 1283331006052 Walker B; other site 1283331006053 D-loop; other site 1283331006054 H-loop/switch region; other site 1283331006055 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283331006056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331006057 dimer interface [polypeptide binding]; other site 1283331006058 conserved gate region; other site 1283331006059 putative PBP binding loops; other site 1283331006060 ABC-ATPase subunit interface; other site 1283331006061 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1283331006062 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1283331006063 ligand binding site [chemical binding]; other site 1283331006064 flexible hinge region; other site 1283331006065 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1283331006066 non-specific DNA interactions [nucleotide binding]; other site 1283331006067 DNA binding site [nucleotide binding] 1283331006068 sequence specific DNA binding site [nucleotide binding]; other site 1283331006069 putative cAMP binding site [chemical binding]; other site 1283331006070 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283331006071 trimer interface; other site 1283331006072 sugar binding site [chemical binding]; other site 1283331006073 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1283331006074 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 1283331006075 putative NAD(P) binding site [chemical binding]; other site 1283331006076 catalytic Zn binding site [ion binding]; other site 1283331006077 structural Zn binding site [ion binding]; other site 1283331006078 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1283331006079 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283331006080 tetrameric interface [polypeptide binding]; other site 1283331006081 activator binding site; other site 1283331006082 NADP binding site [chemical binding]; other site 1283331006083 substrate binding site [chemical binding]; other site 1283331006084 catalytic residues [active] 1283331006085 DAK2 domain; Region: Dak2; pfam02734 1283331006086 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1283331006087 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1283331006088 short chain dehydrogenase; Provisional; Region: PRK06841 1283331006089 classical (c) SDRs; Region: SDR_c; cd05233 1283331006090 NAD(P) binding site [chemical binding]; other site 1283331006091 active site 1283331006092 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1283331006093 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1283331006094 putative ligand binding site [chemical binding]; other site 1283331006095 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283331006096 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1283331006097 TM-ABC transporter signature motif; other site 1283331006098 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1283331006099 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1283331006100 Walker A/P-loop; other site 1283331006101 ATP binding site [chemical binding]; other site 1283331006102 Q-loop/lid; other site 1283331006103 ABC transporter signature motif; other site 1283331006104 Walker B; other site 1283331006105 D-loop; other site 1283331006106 H-loop/switch region; other site 1283331006107 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1283331006108 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1283331006109 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1283331006110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331006111 motif I; other site 1283331006112 motif II; other site 1283331006113 transaldolase-like protein; Provisional; Region: PTZ00411 1283331006114 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1283331006115 active site 1283331006116 dimer interface [polypeptide binding]; other site 1283331006117 catalytic residue [active] 1283331006118 transketolase; Reviewed; Region: PRK12753 1283331006119 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1283331006120 TPP-binding site [chemical binding]; other site 1283331006121 dimer interface [polypeptide binding]; other site 1283331006122 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1283331006123 PYR/PP interface [polypeptide binding]; other site 1283331006124 dimer interface [polypeptide binding]; other site 1283331006125 TPP binding site [chemical binding]; other site 1283331006126 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1283331006127 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1283331006128 active site 1283331006129 dimer interface [polypeptide binding]; other site 1283331006130 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1283331006131 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1283331006132 pyruvate kinase; Provisional; Region: PRK05826 1283331006133 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283331006134 domain interfaces; other site 1283331006135 active site 1283331006136 enolase; Provisional; Region: eno; PRK00077 1283331006137 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283331006138 dimer interface [polypeptide binding]; other site 1283331006139 metal binding site [ion binding]; metal-binding site 1283331006140 substrate binding pocket [chemical binding]; other site 1283331006141 PAS domain; Region: PAS_9; pfam13426 1283331006142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331006143 putative active site [active] 1283331006144 heme pocket [chemical binding]; other site 1283331006145 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1283331006146 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283331006147 DNA binding residues [nucleotide binding] 1283331006148 dimerization interface [polypeptide binding]; other site 1283331006149 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 1283331006150 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1283331006151 active site 1283331006152 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1283331006153 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283331006154 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1283331006155 acyl-activating enzyme (AAE) consensus motif; other site 1283331006156 acyl-activating enzyme (AAE) consensus motif; other site 1283331006157 putative AMP binding site [chemical binding]; other site 1283331006158 putative active site [active] 1283331006159 putative CoA binding site [chemical binding]; other site 1283331006160 guanine deaminase; Provisional; Region: PRK09228 1283331006161 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1283331006162 active site 1283331006163 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1283331006164 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1283331006165 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1283331006166 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1283331006167 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1283331006168 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283331006169 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1283331006170 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331006171 catalytic loop [active] 1283331006172 iron binding site [ion binding]; other site 1283331006173 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1283331006174 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1283331006175 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1283331006176 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1283331006177 active site 1283331006178 purine riboside binding site [chemical binding]; other site 1283331006179 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283331006180 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331006181 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331006182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283331006183 Integrase core domain; Region: rve; pfam00665 1283331006184 Integrase core domain; Region: rve_3; pfam13683 1283331006185 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283331006186 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283331006187 active site 1283331006188 iron coordination sites [ion binding]; other site 1283331006189 substrate binding pocket [chemical binding]; other site 1283331006190 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1283331006191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331006192 Walker A motif; other site 1283331006193 ATP binding site [chemical binding]; other site 1283331006194 Walker B motif; other site 1283331006195 arginine finger; other site 1283331006196 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1283331006197 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1283331006198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1283331006199 Coenzyme A binding pocket [chemical binding]; other site 1283331006200 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331006201 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331006202 active site 1283331006203 catalytic tetrad [active] 1283331006204 glutathionine S-transferase; Provisional; Region: PRK10542 1283331006205 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1283331006206 C-terminal domain interface [polypeptide binding]; other site 1283331006207 GSH binding site (G-site) [chemical binding]; other site 1283331006208 dimer interface [polypeptide binding]; other site 1283331006209 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1283331006210 N-terminal domain interface [polypeptide binding]; other site 1283331006211 dimer interface [polypeptide binding]; other site 1283331006212 substrate binding pocket (H-site) [chemical binding]; other site 1283331006213 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283331006214 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283331006215 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283331006216 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331006217 active site 1283331006218 non-prolyl cis peptide bond; other site 1283331006219 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331006220 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331006221 substrate binding pocket [chemical binding]; other site 1283331006222 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283331006223 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331006224 GntP family permease; Region: GntP_permease; pfam02447 1283331006225 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1283331006226 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1283331006227 AAA domain; Region: AAA_33; pfam13671 1283331006228 ATP-binding site [chemical binding]; other site 1283331006229 Gluconate-6-phosphate binding site [chemical binding]; other site 1283331006230 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1283331006231 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1283331006232 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283331006233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331006234 dimer interface [polypeptide binding]; other site 1283331006235 putative PBP binding loops; other site 1283331006236 ABC-ATPase subunit interface; other site 1283331006237 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283331006238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331006239 putative PBP binding loops; other site 1283331006240 ABC-ATPase subunit interface; other site 1283331006241 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283331006242 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283331006243 Walker A/P-loop; other site 1283331006244 ATP binding site [chemical binding]; other site 1283331006245 Q-loop/lid; other site 1283331006246 ABC transporter signature motif; other site 1283331006247 Walker B; other site 1283331006248 D-loop; other site 1283331006249 H-loop/switch region; other site 1283331006250 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331006251 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1283331006252 TOBE domain; Region: TOBE; cl01440 1283331006253 NAD-dependent deacetylase; Provisional; Region: PRK05333 1283331006254 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1283331006255 glutathionine S-transferase; Provisional; Region: PRK10542 1283331006256 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1283331006257 C-terminal domain interface [polypeptide binding]; other site 1283331006258 GSH binding site (G-site) [chemical binding]; other site 1283331006259 dimer interface [polypeptide binding]; other site 1283331006260 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1283331006261 dimer interface [polypeptide binding]; other site 1283331006262 N-terminal domain interface [polypeptide binding]; other site 1283331006263 substrate binding pocket (H-site) [chemical binding]; other site 1283331006264 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1283331006265 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331006266 N-terminal plug; other site 1283331006267 ligand-binding site [chemical binding]; other site 1283331006268 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283331006269 FecR protein; Region: FecR; pfam04773 1283331006270 RNA polymerase sigma factor; Provisional; Region: PRK12525 1283331006271 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331006272 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331006273 DNA binding residues [nucleotide binding] 1283331006274 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1283331006275 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 1283331006276 diiron binding motif [ion binding]; other site 1283331006277 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1283331006278 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283331006279 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1283331006280 FeoA domain; Region: FeoA; pfam04023 1283331006281 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1283331006282 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1283331006283 G1 box; other site 1283331006284 GTP/Mg2+ binding site [chemical binding]; other site 1283331006285 Switch I region; other site 1283331006286 G2 box; other site 1283331006287 G3 box; other site 1283331006288 Switch II region; other site 1283331006289 G4 box; other site 1283331006290 G5 box; other site 1283331006291 Nucleoside recognition; Region: Gate; pfam07670 1283331006292 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1283331006293 FeoC like transcriptional regulator; Region: FeoC; pfam09012 1283331006294 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1283331006295 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1283331006296 dimerization interface [polypeptide binding]; other site 1283331006297 DPS ferroxidase diiron center [ion binding]; other site 1283331006298 ion pore; other site 1283331006299 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1283331006300 PAS domain; Region: PAS_9; pfam13426 1283331006301 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331006302 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331006303 metal binding site [ion binding]; metal-binding site 1283331006304 active site 1283331006305 I-site; other site 1283331006306 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1283331006307 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283331006308 inhibitor-cofactor binding pocket; inhibition site 1283331006309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331006310 catalytic residue [active] 1283331006311 Ion channel; Region: Ion_trans_2; pfam07885 1283331006312 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1283331006313 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331006314 N-terminal plug; other site 1283331006315 ligand-binding site [chemical binding]; other site 1283331006316 SdiA-regulated; Region: SdiA-regulated; pfam06977 1283331006317 SdiA-regulated; Region: SdiA-regulated; cd09971 1283331006318 putative active site [active] 1283331006319 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1283331006320 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1283331006321 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1283331006322 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1283331006323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1283331006324 Walker A motif; other site 1283331006325 ATP binding site [chemical binding]; other site 1283331006326 Walker B motif; other site 1283331006327 arginine finger; other site 1283331006328 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1283331006329 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1283331006330 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1283331006331 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1283331006332 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283331006333 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1283331006334 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1283331006335 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1283331006336 CHAD domain; Region: CHAD; pfam05235 1283331006337 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1283331006338 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1283331006339 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1283331006340 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1283331006341 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 1283331006342 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1283331006343 active site 1283331006344 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331006345 substrate binding pocket [chemical binding]; other site 1283331006346 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1283331006347 membrane-bound complex binding site; other site 1283331006348 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1283331006349 hinge residues; other site 1283331006350 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283331006351 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283331006352 catalytic residue [active] 1283331006353 2'-5' RNA ligase; Provisional; Region: PRK15124 1283331006354 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1283331006355 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1283331006356 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1283331006357 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1283331006358 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1283331006359 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1283331006360 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1283331006361 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1283331006362 Walker A/P-loop; other site 1283331006363 ATP binding site [chemical binding]; other site 1283331006364 Q-loop/lid; other site 1283331006365 ABC transporter signature motif; other site 1283331006366 Walker B; other site 1283331006367 D-loop; other site 1283331006368 H-loop/switch region; other site 1283331006369 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1283331006370 active site 1283331006371 catalytic triad [active] 1283331006372 oxyanion hole [active] 1283331006373 switch loop; other site 1283331006374 L,D-transpeptidase; Provisional; Region: PRK10260 1283331006375 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1283331006376 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1283331006377 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1283331006378 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1283331006379 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1283331006380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331006381 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1283331006382 substrate binding site [chemical binding]; other site 1283331006383 dimerization interface [polypeptide binding]; other site 1283331006384 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1283331006385 Active Sites [active] 1283331006386 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1283331006387 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1283331006388 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1283331006389 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 1283331006390 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 1283331006391 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 1283331006392 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1283331006393 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1283331006394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283331006395 DNA-binding site [nucleotide binding]; DNA binding site 1283331006396 FCD domain; Region: FCD; pfam07729 1283331006397 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1283331006398 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1283331006399 tetramer interface [polypeptide binding]; other site 1283331006400 active site 1283331006401 Mg2+/Mn2+ binding site [ion binding]; other site 1283331006402 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1283331006403 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1283331006404 dimer interface [polypeptide binding]; other site 1283331006405 active site 1283331006406 citrylCoA binding site [chemical binding]; other site 1283331006407 oxalacetate/citrate binding site [chemical binding]; other site 1283331006408 coenzyme A binding site [chemical binding]; other site 1283331006409 catalytic triad [active] 1283331006410 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1283331006411 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1283331006412 substrate binding site [chemical binding]; other site 1283331006413 ligand binding site [chemical binding]; other site 1283331006414 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1283331006415 substrate binding site [chemical binding]; other site 1283331006416 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1283331006417 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1283331006418 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1283331006419 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1283331006420 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1283331006421 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1283331006422 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1283331006423 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1283331006424 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 1283331006425 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331006426 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331006427 DNA binding residues [nucleotide binding] 1283331006428 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1283331006429 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283331006430 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283331006431 ligand binding site [chemical binding]; other site 1283331006432 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1283331006433 active site 1283331006434 SAM binding site [chemical binding]; other site 1283331006435 homodimer interface [polypeptide binding]; other site 1283331006436 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1283331006437 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1283331006438 [4Fe-4S] binding site [ion binding]; other site 1283331006439 molybdopterin cofactor binding site; other site 1283331006440 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1283331006441 molybdopterin cofactor binding site; other site 1283331006442 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1283331006443 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1283331006444 [2Fe-2S] cluster binding site [ion binding]; other site 1283331006445 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1283331006446 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283331006447 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1283331006448 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1283331006449 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1283331006450 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1283331006451 active site 1283331006452 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1283331006453 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1283331006454 active site 1283331006455 ATP binding site [chemical binding]; other site 1283331006456 substrate binding site [chemical binding]; other site 1283331006457 activation loop (A-loop); other site 1283331006458 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1283331006459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331006460 putative substrate translocation pore; other site 1283331006461 Sulfatase; Region: Sulfatase; cl17466 1283331006462 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1283331006463 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1283331006464 putative substrate binding site [chemical binding]; other site 1283331006465 putative ATP binding site [chemical binding]; other site 1283331006466 Leucine rich repeat; Region: LRR_8; pfam13855 1283331006467 Leucine rich repeat; Region: LRR_8; pfam13855 1283331006468 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1283331006469 active site 1283331006470 ATP binding site [chemical binding]; other site 1283331006471 substrate binding site [chemical binding]; other site 1283331006472 activation loop (A-loop); other site 1283331006473 aminotransferase; Validated; Region: PRK08175 1283331006474 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283331006475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331006476 homodimer interface [polypeptide binding]; other site 1283331006477 catalytic residue [active] 1283331006478 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1283331006479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331006480 active site 1283331006481 phosphorylation site [posttranslational modification] 1283331006482 intermolecular recognition site; other site 1283331006483 dimerization interface [polypeptide binding]; other site 1283331006484 ANTAR domain; Region: ANTAR; pfam03861 1283331006485 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1283331006486 NMT1-like family; Region: NMT1_2; pfam13379 1283331006487 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1283331006488 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1283331006489 substrate binding site [chemical binding]; other site 1283331006490 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1283331006491 substrate binding site [chemical binding]; other site 1283331006492 ligand binding site [chemical binding]; other site 1283331006493 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1283331006494 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1283331006495 dinuclear metal binding motif [ion binding]; other site 1283331006496 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1283331006497 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1283331006498 putative active site [active] 1283331006499 putative metal binding site [ion binding]; other site 1283331006500 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1283331006501 substrate binding site [chemical binding]; other site 1283331006502 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1283331006503 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1283331006504 active site 1283331006505 HIGH motif; other site 1283331006506 nucleotide binding site [chemical binding]; other site 1283331006507 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1283331006508 KMSKS motif; other site 1283331006509 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1283331006510 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1283331006511 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1283331006512 active site 1283331006513 HIGH motif; other site 1283331006514 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1283331006515 KMSKS motif; other site 1283331006516 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1283331006517 tRNA binding surface [nucleotide binding]; other site 1283331006518 anticodon binding site; other site 1283331006519 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1283331006520 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1283331006521 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1283331006522 homodimer interface [polypeptide binding]; other site 1283331006523 NADP binding site [chemical binding]; other site 1283331006524 substrate binding site [chemical binding]; other site 1283331006525 trigger factor; Provisional; Region: tig; PRK01490 1283331006526 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283331006527 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1283331006528 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1283331006529 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1283331006530 oligomer interface [polypeptide binding]; other site 1283331006531 active site residues [active] 1283331006532 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1283331006533 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1283331006534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331006535 Walker A motif; other site 1283331006536 ATP binding site [chemical binding]; other site 1283331006537 Walker B motif; other site 1283331006538 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1283331006539 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1283331006540 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1283331006541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331006542 Walker A motif; other site 1283331006543 ATP binding site [chemical binding]; other site 1283331006544 Walker B motif; other site 1283331006545 arginine finger; other site 1283331006546 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1283331006547 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283331006548 IHF dimer interface [polypeptide binding]; other site 1283331006549 IHF - DNA interface [nucleotide binding]; other site 1283331006550 periplasmic folding chaperone; Provisional; Region: PRK10788 1283331006551 SurA N-terminal domain; Region: SurA_N_3; pfam13624 1283331006552 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1283331006553 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1283331006554 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1283331006555 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 1283331006556 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283331006557 dimer interface [polypeptide binding]; other site 1283331006558 active site 1283331006559 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1283331006560 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1283331006561 NAD(P) binding site [chemical binding]; other site 1283331006562 homotetramer interface [polypeptide binding]; other site 1283331006563 homodimer interface [polypeptide binding]; other site 1283331006564 active site 1283331006565 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1283331006566 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283331006567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331006568 phasin family protein; Region: phasin; TIGR01841 1283331006569 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 1283331006570 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1283331006571 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1283331006572 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1283331006573 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1283331006574 homodecamer interface [polypeptide binding]; other site 1283331006575 GTP cyclohydrolase I; Provisional; Region: PLN03044 1283331006576 active site 1283331006577 putative catalytic site residues [active] 1283331006578 zinc binding site [ion binding]; other site 1283331006579 GTP-CH-I/GFRP interaction surface; other site 1283331006580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1283331006581 Smr domain; Region: Smr; pfam01713 1283331006582 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1283331006583 Isochorismatase family; Region: Isochorismatase; pfam00857 1283331006584 catalytic triad [active] 1283331006585 conserved cis-peptide bond; other site 1283331006586 HemK family putative methylases; Region: hemK_fam; TIGR00536 1283331006587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331006588 S-adenosylmethionine binding site [chemical binding]; other site 1283331006589 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1283331006590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331006591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283331006592 putative substrate translocation pore; other site 1283331006593 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1283331006594 intersubunit interface [polypeptide binding]; other site 1283331006595 active site 1283331006596 Zn2+ binding site [ion binding]; other site 1283331006597 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1283331006598 Cupin domain; Region: Cupin_2; cl17218 1283331006599 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 1283331006600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1283331006601 motif II; other site 1283331006602 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1283331006603 spermidine synthase; Provisional; Region: PRK00811 1283331006604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331006605 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1283331006606 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283331006607 Cytochrome c; Region: Cytochrom_C; pfam00034 1283331006608 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1283331006609 Predicted ATPase [General function prediction only]; Region: COG1485 1283331006610 Predicted permeases [General function prediction only]; Region: COG0679 1283331006611 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331006612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331006613 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283331006614 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283331006615 Alginate lyase; Region: Alginate_lyase2; pfam08787 1283331006616 FlgN protein; Region: FlgN; pfam05130 1283331006617 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1283331006618 SAF-like; Region: SAF_2; pfam13144 1283331006619 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1283331006620 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1283331006621 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1283331006622 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1283331006623 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1283331006624 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1283331006625 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1283331006626 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1283331006627 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1283331006628 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1283331006629 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1283331006630 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1283331006631 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1283331006632 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1283331006633 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1283331006634 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1283331006635 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1283331006636 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1283331006637 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1283331006638 Flagellar L-ring protein; Region: FlgH; pfam02107 1283331006639 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1283331006640 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1283331006641 Rod binding protein; Region: Rod-binding; cl01626 1283331006642 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1283331006643 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1283331006644 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1283331006645 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1283331006646 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1283331006647 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 1283331006648 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1283331006649 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1283331006650 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1283331006651 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1283331006652 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1283331006653 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1283331006654 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1283331006655 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1283331006656 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1283331006657 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1283331006658 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1283331006659 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1283331006660 Flagellar FliJ protein; Region: FliJ; pfam02050 1283331006661 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1283331006662 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1283331006663 Walker A motif/ATP binding site; other site 1283331006664 Walker B motif; other site 1283331006665 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1283331006666 Flagellar assembly protein FliH; Region: FliH; pfam02108 1283331006667 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1283331006668 FliG C-terminal domain; Region: FliG_C; pfam01706 1283331006669 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1283331006670 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1283331006671 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1283331006672 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1283331006673 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1283331006674 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1283331006675 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1283331006676 flagellar protein FliS; Validated; Region: fliS; PRK05685 1283331006677 Flagellar protein FliT; Region: FliT; pfam05400 1283331006678 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1283331006679 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1283331006680 Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247 1283331006681 transcriptional activator FlhC; Provisional; Region: PRK12722 1283331006682 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1283331006683 flagellar motor protein MotA; Validated; Region: PRK09110 1283331006684 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1283331006685 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1283331006686 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283331006687 ligand binding site [chemical binding]; other site 1283331006688 chemotaxis protein CheA; Provisional; Region: PRK10547 1283331006689 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1283331006690 putative binding surface; other site 1283331006691 active site 1283331006692 CheY binding; Region: CheY-binding; pfam09078 1283331006693 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1283331006694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331006695 ATP binding site [chemical binding]; other site 1283331006696 Mg2+ binding site [ion binding]; other site 1283331006697 G-X-G motif; other site 1283331006698 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1283331006699 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1283331006700 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1283331006701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283331006702 dimer interface [polypeptide binding]; other site 1283331006703 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1283331006704 putative CheW interface [polypeptide binding]; other site 1283331006705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331006706 dimerization interface [polypeptide binding]; other site 1283331006707 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1283331006708 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283331006709 dimer interface [polypeptide binding]; other site 1283331006710 putative CheW interface [polypeptide binding]; other site 1283331006711 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331006712 PAS fold; Region: PAS_3; pfam08447 1283331006713 putative active site [active] 1283331006714 heme pocket [chemical binding]; other site 1283331006715 HAMP domain; Region: HAMP; pfam00672 1283331006716 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1283331006717 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283331006718 dimer interface [polypeptide binding]; other site 1283331006719 putative CheW interface [polypeptide binding]; other site 1283331006720 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1283331006721 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1283331006722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331006723 S-adenosylmethionine binding site [chemical binding]; other site 1283331006724 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1283331006725 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283331006726 Walker A/P-loop; other site 1283331006727 ATP binding site [chemical binding]; other site 1283331006728 Q-loop/lid; other site 1283331006729 ABC transporter signature motif; other site 1283331006730 Walker B; other site 1283331006731 D-loop; other site 1283331006732 H-loop/switch region; other site 1283331006733 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1283331006734 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283331006735 Walker A/P-loop; other site 1283331006736 ATP binding site [chemical binding]; other site 1283331006737 Q-loop/lid; other site 1283331006738 ABC transporter signature motif; other site 1283331006739 Walker B; other site 1283331006740 D-loop; other site 1283331006741 H-loop/switch region; other site 1283331006742 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1283331006743 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1283331006744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331006745 dimer interface [polypeptide binding]; other site 1283331006746 conserved gate region; other site 1283331006747 putative PBP binding loops; other site 1283331006748 ABC-ATPase subunit interface; other site 1283331006749 nickel transporter permease NikB; Provisional; Region: PRK10352 1283331006750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331006751 dimer interface [polypeptide binding]; other site 1283331006752 conserved gate region; other site 1283331006753 putative PBP binding loops; other site 1283331006754 ABC-ATPase subunit interface; other site 1283331006755 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1283331006756 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1283331006757 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 1283331006758 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1283331006759 DNA methylase; Region: N6_N4_Mtase; pfam01555 1283331006760 conjugal transfer protein TraL; Provisional; Region: PRK13886 1283331006761 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1283331006762 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1283331006763 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1283331006764 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1283331006765 Ligand Binding Site [chemical binding]; other site 1283331006766 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1283331006767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331006768 dimer interface [polypeptide binding]; other site 1283331006769 phosphorylation site [posttranslational modification] 1283331006770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331006771 ATP binding site [chemical binding]; other site 1283331006772 Mg2+ binding site [ion binding]; other site 1283331006773 G-X-G motif; other site 1283331006774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283331006775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331006776 active site 1283331006777 phosphorylation site [posttranslational modification] 1283331006778 intermolecular recognition site; other site 1283331006779 dimerization interface [polypeptide binding]; other site 1283331006780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331006781 DNA binding site [nucleotide binding] 1283331006782 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1283331006783 potassium uptake protein; Region: kup; TIGR00794 1283331006784 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331006785 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331006786 Transposase domain (DUF772); Region: DUF772; pfam05598 1283331006787 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283331006788 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1283331006789 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1283331006790 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283331006791 putative active site [active] 1283331006792 putative NTP binding site [chemical binding]; other site 1283331006793 putative nucleic acid binding site [nucleotide binding]; other site 1283331006794 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1283331006795 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1283331006796 NAD(P) binding site [chemical binding]; other site 1283331006797 substrate binding site [chemical binding]; other site 1283331006798 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1283331006799 active site 1283331006800 metal-binding site [ion binding] 1283331006801 nucleotide-binding site [chemical binding]; other site 1283331006802 Transposase domain (DUF772); Region: DUF772; pfam05598 1283331006803 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283331006804 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283331006805 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1283331006806 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1283331006807 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1283331006808 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1283331006809 ligand-binding site [chemical binding]; other site 1283331006810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331006811 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283331006812 putative substrate translocation pore; other site 1283331006813 Transposase domain (DUF772); Region: DUF772; pfam05598 1283331006814 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283331006815 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283331006816 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1283331006817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331006818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331006819 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1283331006820 dimerization interface [polypeptide binding]; other site 1283331006821 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283331006822 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283331006823 putative active site [active] 1283331006824 putative NTP binding site [chemical binding]; other site 1283331006825 putative nucleic acid binding site [nucleotide binding]; other site 1283331006826 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1283331006827 dimer interface [polypeptide binding]; other site 1283331006828 FMN binding site [chemical binding]; other site 1283331006829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331006830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331006831 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331006832 putative effector binding pocket; other site 1283331006833 dimerization interface [polypeptide binding]; other site 1283331006834 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1283331006835 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1283331006836 NADP binding site [chemical binding]; other site 1283331006837 dimer interface [polypeptide binding]; other site 1283331006838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1283331006839 Coenzyme A binding pocket [chemical binding]; other site 1283331006840 Predicted integral membrane protein [Function unknown]; Region: COG0392 1283331006841 cardiolipin synthase 2; Provisional; Region: PRK11263 1283331006842 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1283331006843 putative active site [active] 1283331006844 catalytic site [active] 1283331006845 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1283331006846 putative active site [active] 1283331006847 catalytic site [active] 1283331006848 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1283331006849 putative catalytic site [active] 1283331006850 putative metal binding site [ion binding]; other site 1283331006851 putative phosphate binding site [ion binding]; other site 1283331006852 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1283331006853 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1283331006854 NAD binding site [chemical binding]; other site 1283331006855 catalytic Zn binding site [ion binding]; other site 1283331006856 structural Zn binding site [ion binding]; other site 1283331006857 FOG: CBS domain [General function prediction only]; Region: COG0517 1283331006858 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1283331006859 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1283331006860 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1283331006861 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1283331006862 active site 1283331006863 catalytic site [active] 1283331006864 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1283331006865 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1283331006866 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1283331006867 active site 1283331006868 catalytic site [active] 1283331006869 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1283331006870 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1283331006871 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1283331006872 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1283331006873 catalytic site [active] 1283331006874 active site 1283331006875 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1283331006876 glycogen synthase; Provisional; Region: glgA; PRK00654 1283331006877 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1283331006878 ADP-binding pocket [chemical binding]; other site 1283331006879 homodimer interface [polypeptide binding]; other site 1283331006880 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1283331006881 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1283331006882 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1283331006883 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283331006884 FAD binding site [chemical binding]; other site 1283331006885 substrate binding pocket [chemical binding]; other site 1283331006886 catalytic base [active] 1283331006887 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1283331006888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331006889 putative substrate translocation pore; other site 1283331006890 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1283331006891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331006892 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1283331006893 dimerization interface [polypeptide binding]; other site 1283331006894 substrate binding pocket [chemical binding]; other site 1283331006895 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1283331006896 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1283331006897 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1283331006898 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1283331006899 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1283331006900 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1283331006901 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1283331006902 active site 1283331006903 tetramer interface; other site 1283331006904 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283331006905 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1283331006906 active site 1283331006907 metal binding site [ion binding]; metal-binding site 1283331006908 glutathione reductase; Validated; Region: PRK06116 1283331006909 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283331006910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283331006911 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1283331006912 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1283331006913 response regulator; Provisional; Region: PRK09483 1283331006914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331006915 active site 1283331006916 phosphorylation site [posttranslational modification] 1283331006917 intermolecular recognition site; other site 1283331006918 dimerization interface [polypeptide binding]; other site 1283331006919 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283331006920 DNA binding residues [nucleotide binding] 1283331006921 dimerization interface [polypeptide binding]; other site 1283331006922 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1283331006923 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1283331006924 GIY-YIG motif/motif A; other site 1283331006925 active site 1283331006926 catalytic site [active] 1283331006927 putative DNA binding site [nucleotide binding]; other site 1283331006928 metal binding site [ion binding]; metal-binding site 1283331006929 UvrB/uvrC motif; Region: UVR; pfam02151 1283331006930 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1283331006931 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1283331006932 DNA binding site [nucleotide binding] 1283331006933 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1283331006934 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331006935 active site 1283331006936 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1283331006937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283331006938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331006939 H+ Antiporter protein; Region: 2A0121; TIGR00900 1283331006940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331006941 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1283331006942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331006943 NAD(P) binding site [chemical binding]; other site 1283331006944 active site 1283331006945 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1283331006946 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1283331006947 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331006948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331006949 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1283331006950 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 1283331006951 PIN domain; Region: PIN_3; cl17397 1283331006952 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1283331006953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331006954 active site 1283331006955 phosphorylation site [posttranslational modification] 1283331006956 intermolecular recognition site; other site 1283331006957 dimerization interface [polypeptide binding]; other site 1283331006958 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283331006959 Zn2+ binding site [ion binding]; other site 1283331006960 Mg2+ binding site [ion binding]; other site 1283331006961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331006962 dimer interface [polypeptide binding]; other site 1283331006963 phosphorylation site [posttranslational modification] 1283331006964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331006965 ATP binding site [chemical binding]; other site 1283331006966 Mg2+ binding site [ion binding]; other site 1283331006967 G-X-G motif; other site 1283331006968 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331006969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331006970 active site 1283331006971 phosphorylation site [posttranslational modification] 1283331006972 intermolecular recognition site; other site 1283331006973 dimerization interface [polypeptide binding]; other site 1283331006974 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1283331006975 putative binding surface; other site 1283331006976 active site 1283331006977 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1283331006978 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1283331006979 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 1283331006980 PAS domain; Region: PAS; smart00091 1283331006981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331006982 putative active site [active] 1283331006983 heme pocket [chemical binding]; other site 1283331006984 GAF domain; Region: GAF; cl17456 1283331006985 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331006986 metal binding site [ion binding]; metal-binding site 1283331006987 active site 1283331006988 I-site; other site 1283331006989 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283331006990 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331006991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331006992 metal binding site [ion binding]; metal-binding site 1283331006993 active site 1283331006994 I-site; other site 1283331006995 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1283331006996 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1283331006997 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331006998 active site 1283331006999 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1283331007000 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1283331007001 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283331007002 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283331007003 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1283331007004 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1283331007005 Na binding site [ion binding]; other site 1283331007006 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1283331007007 acyl-CoA synthetase; Validated; Region: PRK08162 1283331007008 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1283331007009 acyl-activating enzyme (AAE) consensus motif; other site 1283331007010 putative active site [active] 1283331007011 AMP binding site [chemical binding]; other site 1283331007012 putative CoA binding site [chemical binding]; other site 1283331007013 PAS domain S-box; Region: sensory_box; TIGR00229 1283331007014 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331007015 putative active site [active] 1283331007016 heme pocket [chemical binding]; other site 1283331007017 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1283331007018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331007019 putative active site [active] 1283331007020 heme pocket [chemical binding]; other site 1283331007021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331007022 dimer interface [polypeptide binding]; other site 1283331007023 phosphorylation site [posttranslational modification] 1283331007024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331007025 ATP binding site [chemical binding]; other site 1283331007026 G-X-G motif; other site 1283331007027 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1283331007028 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331007029 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331007030 DNA binding residues [nucleotide binding] 1283331007031 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1283331007032 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1283331007033 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1283331007034 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1283331007035 Water Stress and Hypersensitive response; Region: WHy; smart00769 1283331007036 Penicillin amidase; Region: Penicil_amidase; pfam01804 1283331007037 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1283331007038 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1283331007039 active site 1283331007040 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1283331007041 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1283331007042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331007043 active site 1283331007044 phosphorylation site [posttranslational modification] 1283331007045 intermolecular recognition site; other site 1283331007046 dimerization interface [polypeptide binding]; other site 1283331007047 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283331007048 DNA binding residues [nucleotide binding] 1283331007049 dimerization interface [polypeptide binding]; other site 1283331007050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283331007051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331007052 patatin-related protein; Region: TIGR03607 1283331007053 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1283331007054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331007055 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1283331007056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331007057 DNA binding residues [nucleotide binding] 1283331007058 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283331007059 FecR protein; Region: FecR; pfam04773 1283331007060 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1283331007061 Cupin-like domain; Region: Cupin_8; pfam13621 1283331007062 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1283331007063 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1283331007064 active site 1283331007065 dimer interface [polypeptide binding]; other site 1283331007066 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1283331007067 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1283331007068 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1283331007069 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1283331007070 Transposase; Region: HTH_Tnp_1; cl17663 1283331007071 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331007072 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331007073 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283331007074 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1283331007075 Integrase core domain; Region: rve; pfam00665 1283331007076 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283331007077 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283331007078 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331007079 N-terminal plug; other site 1283331007080 ligand-binding site [chemical binding]; other site 1283331007081 Condensation domain; Region: Condensation; pfam00668 1283331007082 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283331007083 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283331007084 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007085 acyl-activating enzyme (AAE) consensus motif; other site 1283331007086 AMP binding site [chemical binding]; other site 1283331007087 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007088 Condensation domain; Region: Condensation; pfam00668 1283331007089 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283331007090 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1283331007091 Condensation domain; Region: Condensation; pfam00668 1283331007092 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283331007093 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007094 acyl-activating enzyme (AAE) consensus motif; other site 1283331007095 AMP binding site [chemical binding]; other site 1283331007096 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007097 peptide synthase; Provisional; Region: PRK12316 1283331007098 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283331007099 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007100 acyl-activating enzyme (AAE) consensus motif; other site 1283331007101 AMP binding site [chemical binding]; other site 1283331007102 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007103 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1283331007104 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007105 acyl-activating enzyme (AAE) consensus motif; other site 1283331007106 AMP binding site [chemical binding]; other site 1283331007107 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007108 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283331007109 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007110 acyl-activating enzyme (AAE) consensus motif; other site 1283331007111 AMP binding site [chemical binding]; other site 1283331007112 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007113 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1283331007114 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007115 acyl-activating enzyme (AAE) consensus motif; other site 1283331007116 AMP binding site [chemical binding]; other site 1283331007117 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007118 peptide synthase; Provisional; Region: PRK12467 1283331007119 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283331007120 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007121 acyl-activating enzyme (AAE) consensus motif; other site 1283331007122 AMP binding site [chemical binding]; other site 1283331007123 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007124 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283331007125 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007126 acyl-activating enzyme (AAE) consensus motif; other site 1283331007127 AMP binding site [chemical binding]; other site 1283331007128 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007129 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1283331007130 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007131 acyl-activating enzyme (AAE) consensus motif; other site 1283331007132 AMP binding site [chemical binding]; other site 1283331007133 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007134 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283331007135 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283331007136 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007137 acyl-activating enzyme (AAE) consensus motif; other site 1283331007138 AMP binding site [chemical binding]; other site 1283331007139 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007140 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1283331007141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283331007142 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1283331007143 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1283331007144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1283331007145 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1283331007146 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283331007147 inhibitor-cofactor binding pocket; inhibition site 1283331007148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331007149 catalytic residue [active] 1283331007150 peptide synthase; Validated; Region: PRK05691 1283331007151 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1283331007152 acyl-activating enzyme (AAE) consensus motif; other site 1283331007153 active site 1283331007154 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007155 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283331007156 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007157 acyl-activating enzyme (AAE) consensus motif; other site 1283331007158 AMP binding site [chemical binding]; other site 1283331007159 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007160 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283331007161 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007162 acyl-activating enzyme (AAE) consensus motif; other site 1283331007163 AMP binding site [chemical binding]; other site 1283331007164 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007165 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1283331007166 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283331007167 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283331007168 acyl-activating enzyme (AAE) consensus motif; other site 1283331007169 AMP binding site [chemical binding]; other site 1283331007170 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331007171 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1283331007172 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331007173 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331007174 DNA binding residues [nucleotide binding] 1283331007175 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1283331007176 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1283331007177 active site 1283331007178 FMN binding site [chemical binding]; other site 1283331007179 substrate binding site [chemical binding]; other site 1283331007180 3Fe-4S cluster binding site [ion binding]; other site 1283331007181 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1283331007182 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 1283331007183 Int/Topo IB signature motif; other site 1283331007184 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1283331007185 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1283331007186 DNA binding site [nucleotide binding] 1283331007187 dimer interface [polypeptide binding]; other site 1283331007188 active site 1283331007189 Int/Topo IB signature motif; other site 1283331007190 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1283331007191 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331007192 active site 1283331007193 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 1283331007194 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1283331007195 FAD binding pocket [chemical binding]; other site 1283331007196 FAD binding motif [chemical binding]; other site 1283331007197 phosphate binding motif [ion binding]; other site 1283331007198 beta-alpha-beta structure motif; other site 1283331007199 NAD binding pocket [chemical binding]; other site 1283331007200 Iron coordination center [ion binding]; other site 1283331007201 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1283331007202 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1283331007203 putative dimer interface [polypeptide binding]; other site 1283331007204 chaperonin GroEL; Reviewed; Region: groEL; PRK12851 1283331007205 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1283331007206 ring oligomerisation interface [polypeptide binding]; other site 1283331007207 ATP/Mg binding site [chemical binding]; other site 1283331007208 stacking interactions; other site 1283331007209 hinge regions; other site 1283331007210 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331007211 Ligand Binding Site [chemical binding]; other site 1283331007212 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331007213 Ligand Binding Site [chemical binding]; other site 1283331007214 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1283331007215 Catalytic site; other site 1283331007216 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1283331007217 Ligand binding site; other site 1283331007218 metal-binding site 1283331007219 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1283331007220 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1283331007221 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1283331007222 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1283331007223 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1283331007224 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283331007225 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283331007226 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1283331007227 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331007228 catalytic loop [active] 1283331007229 iron binding site [ion binding]; other site 1283331007230 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1283331007231 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331007232 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331007233 active site 1283331007234 catalytic tetrad [active] 1283331007235 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331007236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331007237 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283331007238 putative effector binding pocket; other site 1283331007239 putative dimerization interface [polypeptide binding]; other site 1283331007240 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1283331007241 Sulfatase; Region: Sulfatase; pfam00884 1283331007242 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 1283331007243 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1283331007244 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1283331007245 hypothetical protein; Provisional; Region: PRK02237 1283331007246 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1283331007247 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1283331007248 active site 1283331007249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331007250 dimerization interface [polypeptide binding]; other site 1283331007251 putative DNA binding site [nucleotide binding]; other site 1283331007252 putative Zn2+ binding site [ion binding]; other site 1283331007253 Sodium Bile acid symporter family; Region: SBF; cl17470 1283331007254 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1283331007255 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1283331007256 putative aromatic amino acid binding site; other site 1283331007257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331007258 Walker A motif; other site 1283331007259 ATP binding site [chemical binding]; other site 1283331007260 Walker B motif; other site 1283331007261 arginine finger; other site 1283331007262 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331007263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331007264 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1283331007265 putative substrate translocation pore; other site 1283331007266 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1283331007267 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1283331007268 active site 1283331007269 catalytic residues [active] 1283331007270 metal binding site [ion binding]; metal-binding site 1283331007271 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1283331007272 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1283331007273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331007274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331007275 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1283331007276 putative dimerization interface [polypeptide binding]; other site 1283331007277 glycine dehydrogenase; Provisional; Region: PRK05367 1283331007278 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1283331007279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331007280 tetramer interface [polypeptide binding]; other site 1283331007281 catalytic residue [active] 1283331007282 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1283331007283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331007284 tetramer interface [polypeptide binding]; other site 1283331007285 catalytic residue [active] 1283331007286 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1283331007287 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1283331007288 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1283331007289 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1283331007290 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1283331007291 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1283331007292 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331007293 catalytic loop [active] 1283331007294 iron binding site [ion binding]; other site 1283331007295 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1283331007296 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1283331007297 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283331007298 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1283331007299 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283331007300 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283331007301 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1283331007302 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1283331007303 Walker A/P-loop; other site 1283331007304 ATP binding site [chemical binding]; other site 1283331007305 Q-loop/lid; other site 1283331007306 ABC transporter signature motif; other site 1283331007307 Walker B; other site 1283331007308 D-loop; other site 1283331007309 H-loop/switch region; other site 1283331007310 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1283331007311 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1283331007312 Walker A/P-loop; other site 1283331007313 ATP binding site [chemical binding]; other site 1283331007314 Q-loop/lid; other site 1283331007315 ABC transporter signature motif; other site 1283331007316 Walker B; other site 1283331007317 D-loop; other site 1283331007318 H-loop/switch region; other site 1283331007319 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1283331007320 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1283331007321 TM-ABC transporter signature motif; other site 1283331007322 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283331007323 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1283331007324 TM-ABC transporter signature motif; other site 1283331007325 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1283331007326 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1283331007327 dimerization interface [polypeptide binding]; other site 1283331007328 ligand binding site [chemical binding]; other site 1283331007329 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1283331007330 imidazolonepropionase; Validated; Region: PRK09356 1283331007331 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1283331007332 active site 1283331007333 urocanate hydratase; Provisional; Region: PRK05414 1283331007334 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283331007335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283331007336 DNA binding site [nucleotide binding] 1283331007337 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1283331007338 putative ligand binding site [chemical binding]; other site 1283331007339 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1283331007340 short chain dehydrogenase; Provisional; Region: PRK06198 1283331007341 classical (c) SDRs; Region: SDR_c; cd05233 1283331007342 NAD(P) binding site [chemical binding]; other site 1283331007343 active site 1283331007344 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1283331007345 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1283331007346 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283331007347 putative ligand binding site [chemical binding]; other site 1283331007348 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1283331007349 RES domain; Region: RES; pfam08808 1283331007350 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1283331007351 active sites [active] 1283331007352 tetramer interface [polypeptide binding]; other site 1283331007353 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1283331007354 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1283331007355 active site 1283331007356 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283331007357 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1283331007358 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1283331007359 catalytic residue [active] 1283331007360 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1283331007361 catalytic residues [active] 1283331007362 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283331007363 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283331007364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331007365 PAS domain; Region: PAS_9; pfam13426 1283331007366 putative active site [active] 1283331007367 PAS domain S-box; Region: sensory_box; TIGR00229 1283331007368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331007369 putative active site [active] 1283331007370 heme pocket [chemical binding]; other site 1283331007371 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331007372 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331007373 metal binding site [ion binding]; metal-binding site 1283331007374 active site 1283331007375 I-site; other site 1283331007376 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283331007377 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331007378 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331007379 active site 1283331007380 catalytic tetrad [active] 1283331007381 TLC ATP/ADP transporter; Region: TLC; cl03940 1283331007382 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1283331007383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331007384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331007385 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331007386 putative effector binding pocket; other site 1283331007387 dimerization interface [polypeptide binding]; other site 1283331007388 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283331007389 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331007390 N-terminal plug; other site 1283331007391 ligand-binding site [chemical binding]; other site 1283331007392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1283331007393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331007394 S-adenosylmethionine binding site [chemical binding]; other site 1283331007395 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1283331007396 putative ligand binding residues [chemical binding]; other site 1283331007397 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1283331007398 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1283331007399 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1283331007400 dimer interface [polypeptide binding]; other site 1283331007401 putative PBP binding regions; other site 1283331007402 ABC-ATPase subunit interface; other site 1283331007403 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1283331007404 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1283331007405 Walker A/P-loop; other site 1283331007406 ATP binding site [chemical binding]; other site 1283331007407 Q-loop/lid; other site 1283331007408 ABC transporter signature motif; other site 1283331007409 Walker B; other site 1283331007410 D-loop; other site 1283331007411 H-loop/switch region; other site 1283331007412 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1283331007413 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1283331007414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331007415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331007416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331007417 dimerization interface [polypeptide binding]; other site 1283331007418 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283331007419 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283331007420 Nif-specific regulatory protein; Region: nifA; TIGR01817 1283331007421 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283331007422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331007423 Walker A motif; other site 1283331007424 ATP binding site [chemical binding]; other site 1283331007425 Walker B motif; other site 1283331007426 arginine finger; other site 1283331007427 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331007428 Lysine efflux permease [General function prediction only]; Region: COG1279 1283331007429 Uncharacterized conserved protein [Function unknown]; Region: COG3603 1283331007430 Family description; Region: ACT_7; pfam13840 1283331007431 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1283331007432 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1283331007433 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283331007434 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1283331007435 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1283331007436 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1283331007437 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1283331007438 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283331007439 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283331007440 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1283331007441 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283331007442 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1283331007443 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283331007444 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283331007445 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283331007446 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1283331007447 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1283331007448 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1283331007449 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1283331007450 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1283331007451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331007452 Walker A motif; other site 1283331007453 ATP binding site [chemical binding]; other site 1283331007454 Walker B motif; other site 1283331007455 arginine finger; other site 1283331007456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331007457 Walker A motif; other site 1283331007458 ATP binding site [chemical binding]; other site 1283331007459 Walker B motif; other site 1283331007460 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1283331007461 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1283331007462 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1283331007463 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1283331007464 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1283331007465 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1283331007466 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1283331007467 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1283331007468 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1283331007469 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1283331007470 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1283331007471 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1283331007472 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1283331007473 active site 1283331007474 ATP binding site [chemical binding]; other site 1283331007475 substrate binding site [chemical binding]; other site 1283331007476 activation loop (A-loop); other site 1283331007477 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1283331007478 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1283331007479 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1283331007480 G1 box; other site 1283331007481 GTP/Mg2+ binding site [chemical binding]; other site 1283331007482 G2 box; other site 1283331007483 G3 box; other site 1283331007484 Switch II region; other site 1283331007485 G4 box; other site 1283331007486 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1283331007487 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1283331007488 hypothetical protein; Provisional; Region: PRK07033 1283331007489 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 1283331007490 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283331007491 ligand binding site [chemical binding]; other site 1283331007492 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1283331007493 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1283331007494 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1283331007495 FHA domain; Region: FHA; pfam00498 1283331007496 phosphopeptide binding site; other site 1283331007497 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1283331007498 active site 1283331007499 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 1283331007500 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283331007501 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1283331007502 Walker A/P-loop; other site 1283331007503 ATP binding site [chemical binding]; other site 1283331007504 Q-loop/lid; other site 1283331007505 ABC transporter signature motif; other site 1283331007506 Walker B; other site 1283331007507 D-loop; other site 1283331007508 H-loop/switch region; other site 1283331007509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331007510 metabolite-proton symporter; Region: 2A0106; TIGR00883 1283331007511 putative substrate translocation pore; other site 1283331007512 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1283331007513 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1283331007514 Transposase domain (DUF772); Region: DUF772; pfam05598 1283331007515 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283331007516 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283331007517 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1283331007518 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1283331007519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283331007520 DNA-binding site [nucleotide binding]; DNA binding site 1283331007521 FCD domain; Region: FCD; pfam07729 1283331007522 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283331007523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283331007524 DNA binding site [nucleotide binding] 1283331007525 domain linker motif; other site 1283331007526 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1283331007527 putative dimerization interface [polypeptide binding]; other site 1283331007528 putative ligand binding site [chemical binding]; other site 1283331007529 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1283331007530 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1283331007531 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1283331007532 substrate binding site [chemical binding]; other site 1283331007533 ATP binding site [chemical binding]; other site 1283331007534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331007535 D-galactonate transporter; Region: 2A0114; TIGR00893 1283331007536 putative substrate translocation pore; other site 1283331007537 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1283331007538 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1283331007539 dimerization interface [polypeptide binding]; other site 1283331007540 ligand binding site [chemical binding]; other site 1283331007541 NADP binding site [chemical binding]; other site 1283331007542 catalytic site [active] 1283331007543 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331007544 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283331007545 trimer interface; other site 1283331007546 sugar binding site [chemical binding]; other site 1283331007547 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1283331007548 Na binding site [ion binding]; other site 1283331007549 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 1283331007550 Domain interface; other site 1283331007551 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 1283331007552 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1283331007553 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1283331007554 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1283331007555 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 1283331007556 active site 1283331007557 putative lithium-binding site [ion binding]; other site 1283331007558 substrate binding site [chemical binding]; other site 1283331007559 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1283331007560 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1283331007561 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283331007562 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1283331007563 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1283331007564 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283331007565 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 1283331007566 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1283331007567 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1283331007568 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1283331007569 putative arabinose transporter; Provisional; Region: PRK03545 1283331007570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331007571 putative substrate translocation pore; other site 1283331007572 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1283331007573 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1283331007574 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1283331007575 Class II fumarases; Region: Fumarase_classII; cd01362 1283331007576 active site 1283331007577 tetramer interface [polypeptide binding]; other site 1283331007578 DNA topoisomerase III; Provisional; Region: PRK07726 1283331007579 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1283331007580 active site 1283331007581 putative interdomain interaction site [polypeptide binding]; other site 1283331007582 putative metal-binding site [ion binding]; other site 1283331007583 putative nucleotide binding site [chemical binding]; other site 1283331007584 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1283331007585 domain I; other site 1283331007586 DNA binding groove [nucleotide binding] 1283331007587 phosphate binding site [ion binding]; other site 1283331007588 domain II; other site 1283331007589 domain III; other site 1283331007590 nucleotide binding site [chemical binding]; other site 1283331007591 catalytic site [active] 1283331007592 domain IV; other site 1283331007593 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283331007594 trimer interface; other site 1283331007595 sugar binding site [chemical binding]; other site 1283331007596 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1283331007597 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283331007598 tetrameric interface [polypeptide binding]; other site 1283331007599 activator binding site; other site 1283331007600 NADP binding site [chemical binding]; other site 1283331007601 substrate binding site [chemical binding]; other site 1283331007602 catalytic residues [active] 1283331007603 enolase; Provisional; Region: eno; PRK00077 1283331007604 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283331007605 dimer interface [polypeptide binding]; other site 1283331007606 metal binding site [ion binding]; metal-binding site 1283331007607 substrate binding pocket [chemical binding]; other site 1283331007608 pyruvate kinase; Provisional; Region: PRK05826 1283331007609 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283331007610 domain interfaces; other site 1283331007611 active site 1283331007612 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1283331007613 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1283331007614 active site 1283331007615 intersubunit interface [polypeptide binding]; other site 1283331007616 catalytic residue [active] 1283331007617 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1283331007618 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1283331007619 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1283331007620 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1283331007621 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1283331007622 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1283331007623 putative active site [active] 1283331007624 phosphogluconate dehydratase; Validated; Region: PRK09054 1283331007625 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1283331007626 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283331007627 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283331007628 DNA binding site [nucleotide binding] 1283331007629 domain linker motif; other site 1283331007630 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1283331007631 putative dimerization interface [polypeptide binding]; other site 1283331007632 putative ligand binding site [chemical binding]; other site 1283331007633 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1283331007634 AAA domain; Region: AAA_33; pfam13671 1283331007635 ATP-binding site [chemical binding]; other site 1283331007636 Gluconate-6-phosphate binding site [chemical binding]; other site 1283331007637 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 1283331007638 N- and C-terminal domain interface [polypeptide binding]; other site 1283331007639 D-xylulose kinase; Region: XylB; TIGR01312 1283331007640 active site 1283331007641 MgATP binding site [chemical binding]; other site 1283331007642 catalytic site [active] 1283331007643 metal binding site [ion binding]; metal-binding site 1283331007644 xylulose binding site [chemical binding]; other site 1283331007645 putative homodimer interface [polypeptide binding]; other site 1283331007646 transketolase; Reviewed; Region: PRK12753 1283331007647 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1283331007648 TPP-binding site [chemical binding]; other site 1283331007649 dimer interface [polypeptide binding]; other site 1283331007650 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1283331007651 PYR/PP interface [polypeptide binding]; other site 1283331007652 dimer interface [polypeptide binding]; other site 1283331007653 TPP binding site [chemical binding]; other site 1283331007654 transaldolase-like protein; Provisional; Region: PTZ00411 1283331007655 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1283331007656 active site 1283331007657 dimer interface [polypeptide binding]; other site 1283331007658 catalytic residue [active] 1283331007659 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1283331007660 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1283331007661 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331007662 motif I; other site 1283331007663 motif II; other site 1283331007664 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1283331007665 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1283331007666 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1283331007667 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1283331007668 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1283331007669 Walker A/P-loop; other site 1283331007670 ATP binding site [chemical binding]; other site 1283331007671 Q-loop/lid; other site 1283331007672 ABC transporter signature motif; other site 1283331007673 Walker B; other site 1283331007674 D-loop; other site 1283331007675 H-loop/switch region; other site 1283331007676 TOBE domain; Region: TOBE_2; pfam08402 1283331007677 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1283331007678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331007679 dimer interface [polypeptide binding]; other site 1283331007680 conserved gate region; other site 1283331007681 ABC-ATPase subunit interface; other site 1283331007682 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1283331007683 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1283331007684 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1283331007685 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283331007686 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283331007687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331007688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331007689 phosphoglyceromutase; Provisional; Region: PRK05434 1283331007690 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1283331007691 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1283331007692 Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919 1283331007693 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1283331007694 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1283331007695 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1283331007696 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1283331007697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1283331007698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331007699 S-adenosylmethionine binding site [chemical binding]; other site 1283331007700 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1283331007701 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1283331007702 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1283331007703 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1283331007704 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1283331007705 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283331007706 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283331007707 putative active site [active] 1283331007708 putative NTP binding site [chemical binding]; other site 1283331007709 putative nucleic acid binding site [nucleotide binding]; other site 1283331007710 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1283331007711 putative inner membrane peptidase; Provisional; Region: PRK11778 1283331007712 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1283331007713 tandem repeat interface [polypeptide binding]; other site 1283331007714 oligomer interface [polypeptide binding]; other site 1283331007715 active site residues [active] 1283331007716 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1283331007717 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1283331007718 catalytic core [active] 1283331007719 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1283331007720 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1283331007721 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1283331007722 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1283331007723 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1283331007724 putative NADH binding site [chemical binding]; other site 1283331007725 putative active site [active] 1283331007726 nudix motif; other site 1283331007727 putative metal binding site [ion binding]; other site 1283331007728 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283331007729 ligand binding site [chemical binding]; other site 1283331007730 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1283331007731 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1283331007732 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 1283331007733 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 1283331007734 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1283331007735 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1283331007736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331007737 non-specific DNA binding site [nucleotide binding]; other site 1283331007738 salt bridge; other site 1283331007739 sequence-specific DNA binding site [nucleotide binding]; other site 1283331007740 flagellin; Validated; Region: PRK08026 1283331007741 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1283331007742 Flagellin protein; Region: FliC; pfam12445 1283331007743 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1283331007744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283331007745 TPR motif; other site 1283331007746 TPR repeat; Region: TPR_11; pfam13414 1283331007747 binding surface 1283331007748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283331007749 binding surface 1283331007750 TPR motif; other site 1283331007751 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1283331007752 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283331007753 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1283331007754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1283331007755 active site 1283331007756 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1283331007757 Cephalosporin hydroxylase; Region: CmcI; pfam04989 1283331007758 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1283331007759 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1283331007760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331007761 S-adenosylmethionine binding site [chemical binding]; other site 1283331007762 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1283331007763 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1283331007764 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1283331007765 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1283331007766 NAD binding site [chemical binding]; other site 1283331007767 homotetramer interface [polypeptide binding]; other site 1283331007768 homodimer interface [polypeptide binding]; other site 1283331007769 substrate binding site [chemical binding]; other site 1283331007770 active site 1283331007771 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1283331007772 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1283331007773 substrate binding site; other site 1283331007774 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1283331007775 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283331007776 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1283331007777 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1283331007778 Helix-turn-helix domain; Region: HTH_37; pfam13744 1283331007779 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1283331007780 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1283331007781 HicB family; Region: HicB; pfam05534 1283331007782 FlaG protein; Region: FlaG; pfam03646 1283331007783 PilZ domain; Region: PilZ; pfam07238 1283331007784 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283331007785 Zn2+ binding site [ion binding]; other site 1283331007786 Mg2+ binding site [ion binding]; other site 1283331007787 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1283331007788 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331007789 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1283331007790 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331007791 DNA binding residues [nucleotide binding] 1283331007792 Flagellar protein FlhE; Region: FlhE; pfam06366 1283331007793 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1283331007794 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283331007795 FHIPEP family; Region: FHIPEP; pfam00771 1283331007796 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1283331007797 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1283331007798 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1283331007799 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1283331007800 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1283331007801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331007802 active site 1283331007803 phosphorylation site [posttranslational modification] 1283331007804 intermolecular recognition site; other site 1283331007805 dimerization interface [polypeptide binding]; other site 1283331007806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331007807 dimerization interface [polypeptide binding]; other site 1283331007808 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1283331007809 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283331007810 dimer interface [polypeptide binding]; other site 1283331007811 putative CheW interface [polypeptide binding]; other site 1283331007812 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331007813 dimerization interface [polypeptide binding]; other site 1283331007814 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1283331007815 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283331007816 dimer interface [polypeptide binding]; other site 1283331007817 putative CheW interface [polypeptide binding]; other site 1283331007818 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1283331007819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331007820 active site 1283331007821 phosphorylation site [posttranslational modification] 1283331007822 intermolecular recognition site; other site 1283331007823 dimerization interface [polypeptide binding]; other site 1283331007824 CheB methylesterase; Region: CheB_methylest; pfam01339 1283331007825 glycogen branching enzyme; Provisional; Region: PRK05402 1283331007826 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 1283331007827 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1283331007828 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1283331007829 active site 1283331007830 catalytic site [active] 1283331007831 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1283331007832 trehalose synthase; Region: treS_nterm; TIGR02456 1283331007833 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1283331007834 active site 1283331007835 catalytic site [active] 1283331007836 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1283331007837 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1283331007838 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1283331007839 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1283331007840 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1283331007841 active site 1283331007842 homodimer interface [polypeptide binding]; other site 1283331007843 catalytic site [active] 1283331007844 acceptor binding site [chemical binding]; other site 1283331007845 YcaO domain protein; Region: TIGR03549 1283331007846 OsmC-like protein; Region: OsmC; pfam02566 1283331007847 YcaO-like family; Region: YcaO; pfam02624 1283331007848 Predicted flavoproteins [General function prediction only]; Region: COG2081 1283331007849 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1283331007850 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1283331007851 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283331007852 catalytic residue [active] 1283331007853 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1283331007854 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331007855 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331007856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331007857 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1283331007858 YccA-like proteins; Region: YccA_like; cd10433 1283331007859 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1283331007860 sulfur relay protein TusC; Validated; Region: PRK00211 1283331007861 DsrH like protein; Region: DsrH; pfam04077 1283331007862 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1283331007863 DsrC like protein; Region: DsrC; cl01101 1283331007864 hypothetical protein; Validated; Region: PRK09071 1283331007865 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1283331007866 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1283331007867 siroheme synthase; Provisional; Region: cysG; PRK10637 1283331007868 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1283331007869 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1283331007870 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1283331007871 active site 1283331007872 SAM binding site [chemical binding]; other site 1283331007873 homodimer interface [polypeptide binding]; other site 1283331007874 seryl-tRNA synthetase; Provisional; Region: PRK05431 1283331007875 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1283331007876 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1283331007877 dimer interface [polypeptide binding]; other site 1283331007878 active site 1283331007879 motif 1; other site 1283331007880 motif 2; other site 1283331007881 motif 3; other site 1283331007882 camphor resistance protein CrcB; Provisional; Region: PRK14234 1283331007883 recombination factor protein RarA; Reviewed; Region: PRK13342 1283331007884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331007885 Walker A motif; other site 1283331007886 ATP binding site [chemical binding]; other site 1283331007887 Walker B motif; other site 1283331007888 arginine finger; other site 1283331007889 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1283331007890 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1283331007891 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1283331007892 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1283331007893 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1283331007894 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1283331007895 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1283331007896 thioredoxin reductase; Provisional; Region: PRK10262 1283331007897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283331007898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283331007899 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1283331007900 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1283331007901 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1283331007902 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1283331007903 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1283331007904 rRNA binding site [nucleotide binding]; other site 1283331007905 predicted 30S ribosome binding site; other site 1283331007906 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1283331007907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331007908 Walker A motif; other site 1283331007909 ATP binding site [chemical binding]; other site 1283331007910 Walker B motif; other site 1283331007911 arginine finger; other site 1283331007912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331007913 Walker A motif; other site 1283331007914 ATP binding site [chemical binding]; other site 1283331007915 Walker B motif; other site 1283331007916 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1283331007917 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1283331007918 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1283331007919 DNA-binding site [nucleotide binding]; DNA binding site 1283331007920 RNA-binding motif; other site 1283331007921 isocitrate dehydrogenase, NADP-dependent, monomeric type; Region: monomer_idh; TIGR00178 1283331007922 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1283331007923 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1283331007924 nudix motif; other site 1283331007925 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1283331007926 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1283331007927 putative lysogenization regulator; Reviewed; Region: PRK00218 1283331007928 adenylosuccinate lyase; Provisional; Region: PRK09285 1283331007929 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1283331007930 tetramer interface [polypeptide binding]; other site 1283331007931 active site 1283331007932 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1283331007933 Cupin domain; Region: Cupin_2; cl17218 1283331007934 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283331007935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1283331007936 Coenzyme A binding pocket [chemical binding]; other site 1283331007937 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1283331007938 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1283331007939 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1283331007940 tetramer interface [polypeptide binding]; other site 1283331007941 active site 1283331007942 Mg2+/Mn2+ binding site [ion binding]; other site 1283331007943 isocitrate lyase; Region: PLN02892 1283331007944 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1283331007945 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1283331007946 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1283331007947 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1283331007948 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1283331007949 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1283331007950 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1283331007951 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1283331007952 putative dimer interface [polypeptide binding]; other site 1283331007953 [2Fe-2S] cluster binding site [ion binding]; other site 1283331007954 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1283331007955 SLBB domain; Region: SLBB; pfam10531 1283331007956 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1283331007957 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1283331007958 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331007959 catalytic loop [active] 1283331007960 iron binding site [ion binding]; other site 1283331007961 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1283331007962 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1283331007963 [4Fe-4S] binding site [ion binding]; other site 1283331007964 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1283331007965 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1283331007966 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1283331007967 4Fe-4S binding domain; Region: Fer4; pfam00037 1283331007968 4Fe-4S binding domain; Region: Fer4; pfam00037 1283331007969 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1283331007970 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1283331007971 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1283331007972 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1283331007973 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1283331007974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283331007975 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1283331007976 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283331007977 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1283331007978 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283331007979 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331007980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331007981 ATP binding site [chemical binding]; other site 1283331007982 Mg2+ binding site [ion binding]; other site 1283331007983 G-X-G motif; other site 1283331007984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283331007985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331007986 active site 1283331007987 phosphorylation site [posttranslational modification] 1283331007988 intermolecular recognition site; other site 1283331007989 dimerization interface [polypeptide binding]; other site 1283331007990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331007991 DNA binding site [nucleotide binding] 1283331007992 Predicted membrane protein [Function unknown]; Region: COG3212 1283331007993 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1283331007994 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1283331007995 active site 1283331007996 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1283331007997 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283331007998 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283331007999 catalytic residue [active] 1283331008000 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1283331008001 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1283331008002 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1283331008003 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283331008004 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283331008005 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331008006 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331008007 metal binding site [ion binding]; metal-binding site 1283331008008 active site 1283331008009 I-site; other site 1283331008010 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283331008011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1283331008012 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1283331008013 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1283331008014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331008015 Walker A/P-loop; other site 1283331008016 ATP binding site [chemical binding]; other site 1283331008017 Q-loop/lid; other site 1283331008018 ABC transporter signature motif; other site 1283331008019 Walker B; other site 1283331008020 D-loop; other site 1283331008021 H-loop/switch region; other site 1283331008022 ABC transporter; Region: ABC_tran_2; pfam12848 1283331008023 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283331008024 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1283331008025 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1283331008026 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1283331008027 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1283331008028 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 1283331008029 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1283331008030 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1283331008031 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1283331008032 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1283331008033 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283331008034 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331008035 Strictosidine synthase; Region: Str_synth; pfam03088 1283331008036 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1283331008037 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1283331008038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1283331008039 Family of unknown function (DUF490); Region: DUF490; pfam04357 1283331008040 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1283331008041 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283331008042 Surface antigen; Region: Bac_surface_Ag; pfam01103 1283331008043 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1283331008044 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1283331008045 putative catalytic site [active] 1283331008046 putative phosphate binding site [ion binding]; other site 1283331008047 active site 1283331008048 metal binding site A [ion binding]; metal-binding site 1283331008049 DNA binding site [nucleotide binding] 1283331008050 putative AP binding site [nucleotide binding]; other site 1283331008051 putative metal binding site B [ion binding]; other site 1283331008052 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1283331008053 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283331008054 ligand binding site [chemical binding]; other site 1283331008055 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1283331008056 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1283331008057 NAD(P) binding site [chemical binding]; other site 1283331008058 short chain dehydrogenase; Validated; Region: PRK06182 1283331008059 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1283331008060 NADP binding site [chemical binding]; other site 1283331008061 active site 1283331008062 steroid binding site; other site 1283331008063 Cupin; Region: Cupin_6; pfam12852 1283331008064 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283331008065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331008066 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1283331008067 major facilitator superfamily transporter; Provisional; Region: PRK05122 1283331008068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331008069 putative substrate translocation pore; other site 1283331008070 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283331008071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331008072 active site 1283331008073 phosphorylation site [posttranslational modification] 1283331008074 intermolecular recognition site; other site 1283331008075 dimerization interface [polypeptide binding]; other site 1283331008076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331008077 Walker A motif; other site 1283331008078 ATP binding site [chemical binding]; other site 1283331008079 Walker B motif; other site 1283331008080 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331008081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331008082 dimer interface [polypeptide binding]; other site 1283331008083 phosphorylation site [posttranslational modification] 1283331008084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331008085 ATP binding site [chemical binding]; other site 1283331008086 Mg2+ binding site [ion binding]; other site 1283331008087 G-X-G motif; other site 1283331008088 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1283331008089 catalytic core [active] 1283331008090 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1283331008091 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1283331008092 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1283331008093 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1283331008094 active site 1 [active] 1283331008095 dimer interface [polypeptide binding]; other site 1283331008096 active site 2 [active] 1283331008097 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1283331008098 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1283331008099 dimer interface [polypeptide binding]; other site 1283331008100 active site 1283331008101 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1283331008102 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1283331008103 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1283331008104 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1283331008105 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1283331008106 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1283331008107 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283331008108 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1283331008109 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1283331008110 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1283331008111 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1283331008112 Walker A motif; other site 1283331008113 ATP binding site [chemical binding]; other site 1283331008114 Walker B motif; other site 1283331008115 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331008116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331008117 active site 1283331008118 phosphorylation site [posttranslational modification] 1283331008119 intermolecular recognition site; other site 1283331008120 dimerization interface [polypeptide binding]; other site 1283331008121 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1283331008122 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1283331008123 motif 3; other site 1283331008124 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1283331008125 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1283331008126 trimer interface [polypeptide binding]; other site 1283331008127 active site 1283331008128 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1283331008129 AMIN domain; Region: AMIN; pfam11741 1283331008130 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1283331008131 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1283331008132 active site 1283331008133 metal binding site [ion binding]; metal-binding site 1283331008134 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1283331008135 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1283331008136 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1283331008137 substrate binding pocket [chemical binding]; other site 1283331008138 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1283331008139 B12 binding site [chemical binding]; other site 1283331008140 cobalt ligand [ion binding]; other site 1283331008141 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1283331008142 Protein with unknown function (DUF469); Region: DUF469; pfam04320 1283331008143 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1283331008144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1283331008145 dimerization interface [polypeptide binding]; other site 1283331008146 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331008147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331008148 dimer interface [polypeptide binding]; other site 1283331008149 phosphorylation site [posttranslational modification] 1283331008150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331008151 ATP binding site [chemical binding]; other site 1283331008152 Mg2+ binding site [ion binding]; other site 1283331008153 G-X-G motif; other site 1283331008154 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331008155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331008156 active site 1283331008157 phosphorylation site [posttranslational modification] 1283331008158 intermolecular recognition site; other site 1283331008159 dimerization interface [polypeptide binding]; other site 1283331008160 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331008161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331008162 active site 1283331008163 phosphorylation site [posttranslational modification] 1283331008164 intermolecular recognition site; other site 1283331008165 dimerization interface [polypeptide binding]; other site 1283331008166 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331008167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331008168 metal binding site [ion binding]; metal-binding site 1283331008169 active site 1283331008170 I-site; other site 1283331008171 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1283331008172 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1283331008173 GIY-YIG motif/motif A; other site 1283331008174 active site 1283331008175 catalytic site [active] 1283331008176 putative DNA binding site [nucleotide binding]; other site 1283331008177 metal binding site [ion binding]; metal-binding site 1283331008178 hypothetical protein; Provisional; Region: PRK02487 1283331008179 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 1283331008180 ArsC family; Region: ArsC; pfam03960 1283331008181 putative catalytic residues [active] 1283331008182 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1283331008183 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464 1283331008184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1283331008185 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1283331008186 dimer interface [polypeptide binding]; other site 1283331008187 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283331008188 metal binding site [ion binding]; metal-binding site 1283331008189 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331008190 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331008191 substrate binding pocket [chemical binding]; other site 1283331008192 membrane-bound complex binding site; other site 1283331008193 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283331008194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331008195 putative PBP binding loops; other site 1283331008196 dimer interface [polypeptide binding]; other site 1283331008197 ABC-ATPase subunit interface; other site 1283331008198 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283331008199 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283331008200 Walker A/P-loop; other site 1283331008201 ATP binding site [chemical binding]; other site 1283331008202 Q-loop/lid; other site 1283331008203 ABC transporter signature motif; other site 1283331008204 Walker B; other site 1283331008205 D-loop; other site 1283331008206 H-loop/switch region; other site 1283331008207 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283331008208 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331008209 active site 1283331008210 non-prolyl cis peptide bond; other site 1283331008211 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1283331008212 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1283331008213 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1283331008214 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1283331008215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283331008216 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1283331008217 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1283331008218 FtsX-like permease family; Region: FtsX; pfam02687 1283331008219 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1283331008220 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1283331008221 Walker A/P-loop; other site 1283331008222 ATP binding site [chemical binding]; other site 1283331008223 Q-loop/lid; other site 1283331008224 ABC transporter signature motif; other site 1283331008225 Walker B; other site 1283331008226 D-loop; other site 1283331008227 H-loop/switch region; other site 1283331008228 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1283331008229 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1283331008230 active site 1283331008231 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1283331008232 malonyl-CoA binding site [chemical binding]; other site 1283331008233 dimer interface [polypeptide binding]; other site 1283331008234 active site 1283331008235 product binding site; other site 1283331008236 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1283331008237 2-Nitropropane dioxygenase (NPD)-like domain, associated with polyketide synthases (PKS). NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and...; Region: NPD_PKS; cd04743 1283331008238 FMN binding site [chemical binding]; other site 1283331008239 substrate binding site [chemical binding]; other site 1283331008240 putative catalytic residue [active] 1283331008241 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1283331008242 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1283331008243 active site 1283331008244 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1283331008245 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1283331008246 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331008247 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1283331008248 putative NADP binding site [chemical binding]; other site 1283331008249 active site 1283331008250 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1283331008251 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1283331008252 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1283331008253 homodimer interface [polypeptide binding]; other site 1283331008254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331008255 catalytic residue [active] 1283331008256 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1283331008257 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1283331008258 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1283331008259 active site 1283331008260 catalytic site [active] 1283331008261 substrate binding site [chemical binding]; other site 1283331008262 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1283331008263 RNA/DNA hybrid binding site [nucleotide binding]; other site 1283331008264 active site 1283331008265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331008266 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1283331008267 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1283331008268 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283331008269 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283331008270 catalytic residue [active] 1283331008271 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1283331008272 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1283331008273 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1283331008274 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1283331008275 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1283331008276 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1283331008277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331008278 dimer interface [polypeptide binding]; other site 1283331008279 conserved gate region; other site 1283331008280 putative PBP binding loops; other site 1283331008281 ABC-ATPase subunit interface; other site 1283331008282 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1283331008283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331008284 dimer interface [polypeptide binding]; other site 1283331008285 conserved gate region; other site 1283331008286 putative PBP binding loops; other site 1283331008287 ABC-ATPase subunit interface; other site 1283331008288 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1283331008289 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283331008290 Walker A/P-loop; other site 1283331008291 ATP binding site [chemical binding]; other site 1283331008292 Q-loop/lid; other site 1283331008293 ABC transporter signature motif; other site 1283331008294 Walker B; other site 1283331008295 D-loop; other site 1283331008296 H-loop/switch region; other site 1283331008297 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1283331008298 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283331008299 Walker A/P-loop; other site 1283331008300 ATP binding site [chemical binding]; other site 1283331008301 Q-loop/lid; other site 1283331008302 ABC transporter signature motif; other site 1283331008303 Walker B; other site 1283331008304 D-loop; other site 1283331008305 H-loop/switch region; other site 1283331008306 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1283331008307 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1283331008308 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1283331008309 NAD binding site [chemical binding]; other site 1283331008310 homotetramer interface [polypeptide binding]; other site 1283331008311 homodimer interface [polypeptide binding]; other site 1283331008312 substrate binding site [chemical binding]; other site 1283331008313 active site 1283331008314 xanthine permease; Region: pbuX; TIGR03173 1283331008315 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1283331008316 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1283331008317 EamA-like transporter family; Region: EamA; pfam00892 1283331008318 EamA-like transporter family; Region: EamA; pfam00892 1283331008319 Predicted membrane protein [Function unknown]; Region: COG3821 1283331008320 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1283331008321 CoA binding domain; Region: CoA_binding; pfam02629 1283331008322 CoA-ligase; Region: Ligase_CoA; pfam00549 1283331008323 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1283331008324 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1283331008325 CoA-ligase; Region: Ligase_CoA; pfam00549 1283331008326 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1283331008327 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1283331008328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283331008329 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1283331008330 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1283331008331 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283331008332 E3 interaction surface; other site 1283331008333 lipoyl attachment site [posttranslational modification]; other site 1283331008334 e3 binding domain; Region: E3_binding; pfam02817 1283331008335 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1283331008336 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1283331008337 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1283331008338 TPP-binding site [chemical binding]; other site 1283331008339 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1283331008340 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1283331008341 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1283331008342 L-aspartate oxidase; Provisional; Region: PRK06175 1283331008343 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1283331008344 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1283331008345 SdhC subunit interface [polypeptide binding]; other site 1283331008346 proximal heme binding site [chemical binding]; other site 1283331008347 cardiolipin binding site; other site 1283331008348 Iron-sulfur protein interface; other site 1283331008349 proximal quinone binding site [chemical binding]; other site 1283331008350 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1283331008351 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1283331008352 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1283331008353 dimer interface [polypeptide binding]; other site 1283331008354 active site 1283331008355 citrylCoA binding site [chemical binding]; other site 1283331008356 NADH binding [chemical binding]; other site 1283331008357 cationic pore residues; other site 1283331008358 oxalacetate/citrate binding site [chemical binding]; other site 1283331008359 coenzyme A binding site [chemical binding]; other site 1283331008360 catalytic triad [active] 1283331008361 Flagellin N-methylase; Region: FliB; cl00497 1283331008362 Protein of unknown function, DUF486; Region: DUF486; pfam04342 1283331008363 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1283331008364 active site 1283331008365 catalytic site [active] 1283331008366 substrate binding site [chemical binding]; other site 1283331008367 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1283331008368 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 1283331008369 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1283331008370 ligand binding site [chemical binding]; other site 1283331008371 NAD binding site [chemical binding]; other site 1283331008372 catalytic site [active] 1283331008373 homodimer interface [polypeptide binding]; other site 1283331008374 multidrug efflux protein; Reviewed; Region: PRK01766 1283331008375 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1283331008376 cation binding site [ion binding]; other site 1283331008377 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1283331008378 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1283331008379 active site 1283331008380 tyrosine kinase; Provisional; Region: PRK11519 1283331008381 Chain length determinant protein; Region: Wzz; pfam02706 1283331008382 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1283331008383 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1283331008384 Nucleotide binding site [chemical binding]; other site 1283331008385 DTAP/Switch II; other site 1283331008386 Switch I; other site 1283331008387 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1283331008388 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283331008389 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1283331008390 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1283331008391 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 1283331008392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331008393 NAD(P) binding site [chemical binding]; other site 1283331008394 active site 1283331008395 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1283331008396 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1283331008397 Walker A/P-loop; other site 1283331008398 ATP binding site [chemical binding]; other site 1283331008399 Q-loop/lid; other site 1283331008400 ABC transporter signature motif; other site 1283331008401 Walker B; other site 1283331008402 D-loop; other site 1283331008403 H-loop/switch region; other site 1283331008404 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331008405 active site 1283331008406 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1283331008407 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1283331008408 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1283331008409 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1283331008410 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1283331008411 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1283331008412 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1283331008413 active site 1283331008414 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1283331008415 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1283331008416 Probable Catalytic site; other site 1283331008417 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1283331008418 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1283331008419 putative ADP-binding pocket [chemical binding]; other site 1283331008420 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1283331008421 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283331008422 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283331008423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283331008424 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283331008425 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283331008426 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1283331008427 putative ADP-binding pocket [chemical binding]; other site 1283331008428 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1283331008429 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1283331008430 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1283331008431 putative trimer interface [polypeptide binding]; other site 1283331008432 putative CoA binding site [chemical binding]; other site 1283331008433 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1283331008434 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1283331008435 inhibitor-cofactor binding pocket; inhibition site 1283331008436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331008437 catalytic residue [active] 1283331008438 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1283331008439 CoA binding domain; Region: CoA_binding; cl17356 1283331008440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331008441 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1283331008442 NAD(P) binding site [chemical binding]; other site 1283331008443 homodimer interface [polypeptide binding]; other site 1283331008444 substrate binding site [chemical binding]; other site 1283331008445 active site 1283331008446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1283331008447 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1283331008448 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1283331008449 active site 1283331008450 putative glycosyl transferase; Provisional; Region: PRK10073 1283331008451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1283331008452 active site 1283331008453 polysaccharide export protein Wza; Provisional; Region: PRK15078 1283331008454 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1283331008455 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1283331008456 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1283331008457 acyl-activating enzyme (AAE) consensus motif; other site 1283331008458 putative AMP binding site [chemical binding]; other site 1283331008459 putative active site [active] 1283331008460 putative CoA binding site [chemical binding]; other site 1283331008461 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1283331008462 dimer interaction site [polypeptide binding]; other site 1283331008463 substrate-binding tunnel; other site 1283331008464 active site 1283331008465 catalytic site [active] 1283331008466 substrate binding site [chemical binding]; other site 1283331008467 cytosine deaminase; Provisional; Region: PRK09230 1283331008468 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1283331008469 active site 1283331008470 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283331008471 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283331008472 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283331008473 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331008474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331008475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331008476 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331008477 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331008478 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1283331008479 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283331008480 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283331008481 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 1283331008482 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283331008483 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1283331008484 ATP-dependent helicase HepA; Validated; Region: PRK04914 1283331008485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283331008486 ATP binding site [chemical binding]; other site 1283331008487 putative Mg++ binding site [ion binding]; other site 1283331008488 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331008489 nucleotide binding region [chemical binding]; other site 1283331008490 ATP-binding site [chemical binding]; other site 1283331008491 Ligase N family; Region: LIGANc; smart00532 1283331008492 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1283331008493 nucleotide binding pocket [chemical binding]; other site 1283331008494 K-X-D-G motif; other site 1283331008495 catalytic site [active] 1283331008496 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1283331008497 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1283331008498 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1283331008499 Dimer interface [polypeptide binding]; other site 1283331008500 BRCT sequence motif; other site 1283331008501 cell division protein ZipA; Reviewed; Region: zipA; PRK00269 1283331008502 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 1283331008503 FtsZ protein binding site [polypeptide binding]; other site 1283331008504 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1283331008505 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1283331008506 Walker A/P-loop; other site 1283331008507 ATP binding site [chemical binding]; other site 1283331008508 Q-loop/lid; other site 1283331008509 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1283331008510 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1283331008511 ABC transporter signature motif; other site 1283331008512 Walker B; other site 1283331008513 D-loop; other site 1283331008514 H-loop/switch region; other site 1283331008515 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1283331008516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331008517 FeS/SAM binding site; other site 1283331008518 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1283331008519 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1283331008520 Ion channel; Region: Ion_trans_2; pfam07885 1283331008521 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1283331008522 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1283331008523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283331008524 binding surface 1283331008525 TPR motif; other site 1283331008526 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1283331008527 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1283331008528 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1283331008529 catalytic residues [active] 1283331008530 central insert; other site 1283331008531 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1283331008532 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1283331008533 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1283331008534 heme exporter protein CcmC; Region: ccmC; TIGR01191 1283331008535 heme exporter protein CcmB; Region: ccmB; TIGR01190 1283331008536 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1283331008537 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1283331008538 Walker A/P-loop; other site 1283331008539 ATP binding site [chemical binding]; other site 1283331008540 Q-loop/lid; other site 1283331008541 ABC transporter signature motif; other site 1283331008542 Walker B; other site 1283331008543 D-loop; other site 1283331008544 H-loop/switch region; other site 1283331008545 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1283331008546 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1283331008547 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1283331008548 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1283331008549 E-class dimer interface [polypeptide binding]; other site 1283331008550 P-class dimer interface [polypeptide binding]; other site 1283331008551 active site 1283331008552 Cu2+ binding site [ion binding]; other site 1283331008553 Zn2+ binding site [ion binding]; other site 1283331008554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331008555 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1283331008556 Walker A/P-loop; other site 1283331008557 ATP binding site [chemical binding]; other site 1283331008558 Q-loop/lid; other site 1283331008559 ABC transporter signature motif; other site 1283331008560 Walker B; other site 1283331008561 D-loop; other site 1283331008562 H-loop/switch region; other site 1283331008563 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283331008564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331008565 dimer interface [polypeptide binding]; other site 1283331008566 conserved gate region; other site 1283331008567 putative PBP binding loops; other site 1283331008568 ABC-ATPase subunit interface; other site 1283331008569 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1283331008570 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283331008571 active site 1283331008572 dimer interface [polypeptide binding]; other site 1283331008573 non-prolyl cis peptide bond; other site 1283331008574 insertion regions; other site 1283331008575 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331008576 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331008577 substrate binding pocket [chemical binding]; other site 1283331008578 membrane-bound complex binding site; other site 1283331008579 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1283331008580 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283331008581 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1283331008582 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1283331008583 dimer interface [polypeptide binding]; other site 1283331008584 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1283331008585 catalytic triad [active] 1283331008586 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1283331008587 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1283331008588 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1283331008589 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1283331008590 dimerization interface [polypeptide binding]; other site 1283331008591 ligand binding site [chemical binding]; other site 1283331008592 NADP binding site [chemical binding]; other site 1283331008593 catalytic site [active] 1283331008594 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1283331008595 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1283331008596 active site 1283331008597 catalytic residues [active] 1283331008598 metal binding site [ion binding]; metal-binding site 1283331008599 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1283331008600 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1283331008601 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283331008602 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1283331008603 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1283331008604 active site 1 [active] 1283331008605 dimer interface [polypeptide binding]; other site 1283331008606 hexamer interface [polypeptide binding]; other site 1283331008607 active site 2 [active] 1283331008608 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283331008609 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283331008610 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 1283331008611 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1283331008612 NAD binding site [chemical binding]; other site 1283331008613 catalytic residues [active] 1283331008614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331008615 non-specific DNA binding site [nucleotide binding]; other site 1283331008616 salt bridge; other site 1283331008617 sequence-specific DNA binding site [nucleotide binding]; other site 1283331008618 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1283331008619 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1283331008620 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1283331008621 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1283331008622 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1283331008623 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1283331008624 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1283331008625 HicB family; Region: HicB; pfam05534 1283331008626 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1283331008627 ArsC family; Region: ArsC; pfam03960 1283331008628 catalytic residues [active] 1283331008629 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1283331008630 arsenical-resistance protein; Region: acr3; TIGR00832 1283331008631 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1283331008632 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1283331008633 active site 1283331008634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331008635 dimerization interface [polypeptide binding]; other site 1283331008636 putative DNA binding site [nucleotide binding]; other site 1283331008637 putative Zn2+ binding site [ion binding]; other site 1283331008638 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1283331008639 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331008640 catalytic loop [active] 1283331008641 iron binding site [ion binding]; other site 1283331008642 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 1283331008643 FAD binding pocket [chemical binding]; other site 1283331008644 FAD binding motif [chemical binding]; other site 1283331008645 phosphate binding motif [ion binding]; other site 1283331008646 beta-alpha-beta structure motif; other site 1283331008647 NAD binding pocket [chemical binding]; other site 1283331008648 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 1283331008649 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 1283331008650 dimerization interface [polypeptide binding]; other site 1283331008651 putative path to active site cavity [active] 1283331008652 diiron center [ion binding]; other site 1283331008653 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 1283331008654 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 1283331008655 dimerization interface [polypeptide binding]; other site 1283331008656 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 1283331008657 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1283331008658 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 1283331008659 tetramer interface [polypeptide binding]; other site 1283331008660 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 1283331008661 tetramer interface [polypeptide binding]; other site 1283331008662 active site 1283331008663 Fe binding site [ion binding]; other site 1283331008664 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 1283331008665 putative uracil binding site [chemical binding]; other site 1283331008666 putative active site [active] 1283331008667 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331008668 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331008669 Activator of aromatic catabolism; Region: XylR_N; pfam06505 1283331008670 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1283331008671 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1283331008672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331008673 Walker A motif; other site 1283331008674 ATP binding site [chemical binding]; other site 1283331008675 Walker B motif; other site 1283331008676 arginine finger; other site 1283331008677 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331008678 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1283331008679 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1283331008680 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1283331008681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331008682 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446 1283331008683 dimerization interface [polypeptide binding]; other site 1283331008684 putative substrate binding pocket [chemical binding]; other site 1283331008685 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283331008686 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331008687 N-terminal plug; other site 1283331008688 ligand-binding site [chemical binding]; other site 1283331008689 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1283331008690 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1283331008691 putative ligand binding residues [chemical binding]; other site 1283331008692 NMT1-like family; Region: NMT1_2; pfam13379 1283331008693 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331008694 substrate binding pocket [chemical binding]; other site 1283331008695 membrane-bound complex binding site; other site 1283331008696 hinge residues; other site 1283331008697 malonic semialdehyde reductase; Provisional; Region: PRK10538 1283331008698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331008699 NAD(P) binding site [chemical binding]; other site 1283331008700 active site 1283331008701 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283331008702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331008703 putative PBP binding loops; other site 1283331008704 ABC-ATPase subunit interface; other site 1283331008705 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283331008706 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283331008707 Walker A/P-loop; other site 1283331008708 ATP binding site [chemical binding]; other site 1283331008709 Q-loop/lid; other site 1283331008710 ABC transporter signature motif; other site 1283331008711 Walker B; other site 1283331008712 D-loop; other site 1283331008713 H-loop/switch region; other site 1283331008714 NMT1-like family; Region: NMT1_2; pfam13379 1283331008715 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331008716 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283331008717 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283331008718 active site 1283331008719 iron coordination sites [ion binding]; other site 1283331008720 substrate binding pocket [chemical binding]; other site 1283331008721 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1283331008722 active site residue [active] 1283331008723 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1283331008724 active site residue [active] 1283331008725 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1283331008726 active site residue [active] 1283331008727 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 1283331008728 active site residue [active] 1283331008729 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1283331008730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331008731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331008732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283331008733 dimerization interface [polypeptide binding]; other site 1283331008734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331008735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331008736 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331008737 putative effector binding pocket; other site 1283331008738 dimerization interface [polypeptide binding]; other site 1283331008739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331008740 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1283331008741 NAD(P) binding site [chemical binding]; other site 1283331008742 active site 1283331008743 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1283331008744 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1283331008745 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1283331008746 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1283331008747 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1283331008748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331008749 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1283331008750 putative effector binding pocket; other site 1283331008751 putative dimerization interface [polypeptide binding]; other site 1283331008752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331008753 salt bridge; other site 1283331008754 non-specific DNA binding site [nucleotide binding]; other site 1283331008755 sequence-specific DNA binding site [nucleotide binding]; other site 1283331008756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1283331008757 non-specific DNA binding site [nucleotide binding]; other site 1283331008758 salt bridge; other site 1283331008759 sequence-specific DNA binding site [nucleotide binding]; other site 1283331008760 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1283331008761 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1283331008762 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283331008763 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1283331008764 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1283331008765 active site 1283331008766 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283331008767 NMT1/THI5 like; Region: NMT1; pfam09084 1283331008768 substrate binding pocket [chemical binding]; other site 1283331008769 membrane-bound complex binding site; other site 1283331008770 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283331008771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331008772 dimer interface [polypeptide binding]; other site 1283331008773 conserved gate region; other site 1283331008774 putative PBP binding loops; other site 1283331008775 ABC-ATPase subunit interface; other site 1283331008776 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283331008777 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283331008778 Walker A/P-loop; other site 1283331008779 ATP binding site [chemical binding]; other site 1283331008780 Q-loop/lid; other site 1283331008781 ABC transporter signature motif; other site 1283331008782 Walker B; other site 1283331008783 D-loop; other site 1283331008784 H-loop/switch region; other site 1283331008785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331008786 dimerization interface [polypeptide binding]; other site 1283331008787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331008788 dimer interface [polypeptide binding]; other site 1283331008789 phosphorylation site [posttranslational modification] 1283331008790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331008791 ATP binding site [chemical binding]; other site 1283331008792 Mg2+ binding site [ion binding]; other site 1283331008793 G-X-G motif; other site 1283331008794 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1283331008795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331008796 active site 1283331008797 phosphorylation site [posttranslational modification] 1283331008798 intermolecular recognition site; other site 1283331008799 dimerization interface [polypeptide binding]; other site 1283331008800 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331008801 DNA binding site [nucleotide binding] 1283331008802 Bacterial SH3 domain; Region: SH3_3; pfam08239 1283331008803 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331008804 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1283331008805 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1283331008806 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1283331008807 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1283331008808 transcriptional activator TtdR; Provisional; Region: PRK09801 1283331008809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331008810 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1283331008811 putative effector binding pocket; other site 1283331008812 putative dimerization interface [polypeptide binding]; other site 1283331008813 benzoate transport; Region: 2A0115; TIGR00895 1283331008814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331008815 putative substrate translocation pore; other site 1283331008816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331008817 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 1283331008818 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 1283331008819 putative active site [active] 1283331008820 Fe(II) binding site [ion binding]; other site 1283331008821 putative dimer interface [polypeptide binding]; other site 1283331008822 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 1283331008823 putative dimer interface [polypeptide binding]; other site 1283331008824 putative N- and C-terminal domain interface [polypeptide binding]; other site 1283331008825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331008826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331008827 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1283331008828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331008829 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1283331008830 putative dimerization interface [polypeptide binding]; other site 1283331008831 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1283331008832 hypothetical protein; Provisional; Region: PRK09262 1283331008833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1283331008834 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331008835 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283331008836 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1283331008837 dimer interface [polypeptide binding]; other site 1283331008838 active site 1283331008839 non-prolyl cis peptide bond; other site 1283331008840 insertion regions; other site 1283331008841 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1283331008842 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283331008843 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331008844 active site 1283331008845 non-prolyl cis peptide bond; other site 1283331008846 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1283331008847 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283331008848 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331008849 active site 1283331008850 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331008851 substrate binding pocket [chemical binding]; other site 1283331008852 membrane-bound complex binding site; other site 1283331008853 hinge residues; other site 1283331008854 aldolase II superfamily protein; Provisional; Region: PRK07044 1283331008855 active site 1283331008856 intersubunit interface [polypeptide binding]; other site 1283331008857 Zn2+ binding site [ion binding]; other site 1283331008858 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283331008859 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331008860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331008861 membrane-bound complex binding site; other site 1283331008862 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331008863 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331008864 membrane-bound complex binding site; other site 1283331008865 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1283331008866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331008867 Walker A motif; other site 1283331008868 ATP binding site [chemical binding]; other site 1283331008869 Walker B motif; other site 1283331008870 arginine finger; other site 1283331008871 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331008872 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283331008873 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283331008874 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283331008875 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1283331008876 Isochorismatase family; Region: Isochorismatase; pfam00857 1283331008877 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1283331008878 catalytic triad [active] 1283331008879 dimer interface [polypeptide binding]; other site 1283331008880 conserved cis-peptide bond; other site 1283331008881 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1283331008882 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1283331008883 active site 1283331008884 metal binding site [ion binding]; metal-binding site 1283331008885 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283331008886 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331008887 active site 1283331008888 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283331008889 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1283331008890 Flavin binding site [chemical binding]; other site 1283331008891 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331008892 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283331008893 active site 1283331008894 non-prolyl cis peptide bond; other site 1283331008895 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1283331008896 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1283331008897 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1283331008898 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1283331008899 Walker A/P-loop; other site 1283331008900 ATP binding site [chemical binding]; other site 1283331008901 Q-loop/lid; other site 1283331008902 ABC transporter signature motif; other site 1283331008903 Walker B; other site 1283331008904 D-loop; other site 1283331008905 H-loop/switch region; other site 1283331008906 NIL domain; Region: NIL; pfam09383 1283331008907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331008908 dimer interface [polypeptide binding]; other site 1283331008909 conserved gate region; other site 1283331008910 ABC-ATPase subunit interface; other site 1283331008911 transposase/IS protein; Provisional; Region: PRK09183 1283331008912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331008913 Walker A motif; other site 1283331008914 ATP binding site [chemical binding]; other site 1283331008915 Walker B motif; other site 1283331008916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1283331008917 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1283331008918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1283331008919 DNA binding site [nucleotide binding] 1283331008920 DNA-binding interface [nucleotide binding]; DNA binding site 1283331008921 domain linker motif; other site 1283331008922 Integrase core domain; Region: rve; pfam00665 1283331008923 Integrase core domain; Region: rve_3; cl15866 1283331008924 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1283331008925 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1283331008926 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 1283331008927 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 1283331008928 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 1283331008929 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1283331008930 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 1283331008931 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1283331008932 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1283331008933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1283331008934 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283331008935 dimerization interface [polypeptide binding]; other site 1283331008936 substrate binding pocket [chemical binding]; other site 1283331008937 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331008938 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331008939 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331008940 substrate binding pocket [chemical binding]; other site 1283331008941 membrane-bound complex binding site; other site 1283331008942 hinge residues; other site 1283331008943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331008944 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1283331008945 Walker A motif; other site 1283331008946 ATP binding site [chemical binding]; other site 1283331008947 Walker B motif; other site 1283331008948 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1283331008949 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283331008950 Uncharacterized small protein [Function unknown]; Region: COG5583 1283331008951 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1283331008952 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1283331008953 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1283331008954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331008955 dimer interface [polypeptide binding]; other site 1283331008956 conserved gate region; other site 1283331008957 putative PBP binding loops; other site 1283331008958 ABC-ATPase subunit interface; other site 1283331008959 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1283331008960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331008961 dimer interface [polypeptide binding]; other site 1283331008962 conserved gate region; other site 1283331008963 putative PBP binding loops; other site 1283331008964 ABC-ATPase subunit interface; other site 1283331008965 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1283331008966 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1283331008967 Walker A/P-loop; other site 1283331008968 ATP binding site [chemical binding]; other site 1283331008969 Q-loop/lid; other site 1283331008970 ABC transporter signature motif; other site 1283331008971 Walker B; other site 1283331008972 D-loop; other site 1283331008973 H-loop/switch region; other site 1283331008974 TOBE-like domain; Region: TOBE_3; pfam12857 1283331008975 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1283331008976 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1283331008977 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1283331008978 Alginate lyase; Region: Alginate_lyase2; pfam08787 1283331008979 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1283331008980 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1283331008981 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1283331008982 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1283331008983 putative active site [active] 1283331008984 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1283331008985 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1283331008986 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1283331008987 active site 1283331008988 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1283331008989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331008990 non-specific DNA binding site [nucleotide binding]; other site 1283331008991 salt bridge; other site 1283331008992 sequence-specific DNA binding site [nucleotide binding]; other site 1283331008993 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1283331008994 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1283331008995 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1283331008996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331008997 non-specific DNA binding site [nucleotide binding]; other site 1283331008998 salt bridge; other site 1283331008999 sequence-specific DNA binding site [nucleotide binding]; other site 1283331009000 Tim44-like domain; Region: Tim44; cl09208 1283331009001 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1283331009002 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1283331009003 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 1283331009004 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1283331009005 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1283331009006 flavodoxin FldA; Validated; Region: PRK09267 1283331009007 Protein of unknown function (DUF2023); Region: DUF2023; pfam09633 1283331009008 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1283331009009 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1283331009010 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1283331009011 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1283331009012 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283331009013 Flavin binding site [chemical binding]; other site 1283331009014 Transposase domain (DUF772); Region: DUF772; pfam05598 1283331009015 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283331009016 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283331009017 MarR family; Region: MarR_2; cl17246 1283331009018 succinic semialdehyde dehydrogenase; Region: PLN02278 1283331009019 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1283331009020 tetramerization interface [polypeptide binding]; other site 1283331009021 NAD(P) binding site [chemical binding]; other site 1283331009022 catalytic residues [active] 1283331009023 D-galactonate transporter; Region: 2A0114; TIGR00893 1283331009024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009025 putative substrate translocation pore; other site 1283331009026 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1283331009027 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1283331009028 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331009029 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283331009030 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331009031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331009032 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1283331009033 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 1283331009034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283331009035 catalytic site [active] 1283331009036 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1283331009037 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1283331009038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009039 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1283331009040 putative substrate translocation pore; other site 1283331009041 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1283331009042 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1283331009043 putative NAD(P) binding site [chemical binding]; other site 1283331009044 putative substrate binding site [chemical binding]; other site 1283331009045 catalytic Zn binding site [ion binding]; other site 1283331009046 structural Zn binding site [ion binding]; other site 1283331009047 dimer interface [polypeptide binding]; other site 1283331009048 RES domain; Region: RES; smart00953 1283331009049 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283331009050 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1283331009051 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1283331009052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283331009053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331009054 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1283331009055 NAD(P) binding site [chemical binding]; other site 1283331009056 active site 1283331009057 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1283331009058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331009059 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283331009060 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009062 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283331009063 putative effector binding pocket; other site 1283331009064 putative dimerization interface [polypeptide binding]; other site 1283331009065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009067 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283331009068 putative effector binding pocket; other site 1283331009069 putative dimerization interface [polypeptide binding]; other site 1283331009070 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331009071 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331009072 active site 1283331009073 catalytic tetrad [active] 1283331009074 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1283331009075 short chain dehydrogenase; Provisional; Region: PRK06180 1283331009076 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1283331009077 NADP binding site [chemical binding]; other site 1283331009078 active site 1283331009079 steroid binding site; other site 1283331009080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331009081 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331009082 active site 1283331009083 catalytic tetrad [active] 1283331009084 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331009085 active site 1283331009086 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331009087 catalytic tetrad [active] 1283331009088 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1283331009089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1283331009090 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283331009091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009092 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1283331009093 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1283331009094 FMN binding site [chemical binding]; other site 1283331009095 active site 1283331009096 catalytic residues [active] 1283331009097 substrate binding site [chemical binding]; other site 1283331009098 transaldolase-like protein; Provisional; Region: PTZ00411 1283331009099 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1283331009100 active site 1283331009101 dimer interface [polypeptide binding]; other site 1283331009102 catalytic residue [active] 1283331009103 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1283331009104 anti sigma factor interaction site; other site 1283331009105 regulatory phosphorylation site [posttranslational modification]; other site 1283331009106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331009107 active site 1283331009108 phosphorylation site [posttranslational modification] 1283331009109 intermolecular recognition site; other site 1283331009110 dimerization interface [polypeptide binding]; other site 1283331009111 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1283331009112 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1283331009113 VacJ like lipoprotein; Region: VacJ; cl01073 1283331009114 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 1283331009115 MASE2 domain; Region: MASE2; pfam05230 1283331009116 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1283331009117 cyclase homology domain; Region: CHD; cd07302 1283331009118 nucleotidyl binding site; other site 1283331009119 metal binding site [ion binding]; metal-binding site 1283331009120 dimer interface [polypeptide binding]; other site 1283331009121 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283331009122 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1283331009123 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1283331009124 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1283331009125 putative active site [active] 1283331009126 putative metal binding site [ion binding]; other site 1283331009127 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 1283331009128 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1283331009129 MarR family; Region: MarR_2; pfam12802 1283331009130 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1283331009131 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283331009132 ATP binding site [chemical binding]; other site 1283331009133 putative Mg++ binding site [ion binding]; other site 1283331009134 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331009135 nucleotide binding region [chemical binding]; other site 1283331009136 ATP-binding site [chemical binding]; other site 1283331009137 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1283331009138 HRDC domain; Region: HRDC; pfam00570 1283331009139 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1283331009140 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1283331009141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1283331009142 DTW domain; Region: DTW; cl01221 1283331009143 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1283331009144 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1283331009145 dimer interface [polypeptide binding]; other site 1283331009146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331009147 catalytic residue [active] 1283331009148 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1283331009149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331009150 Walker A motif; other site 1283331009151 ATP binding site [chemical binding]; other site 1283331009152 Walker B motif; other site 1283331009153 arginine finger; other site 1283331009154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1283331009155 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1283331009156 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1283331009157 putative active site [active] 1283331009158 putative dimer interface [polypeptide binding]; other site 1283331009159 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1283331009160 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283331009161 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1283331009162 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1283331009163 hypothetical protein; Provisional; Region: PRK05170 1283331009164 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1283331009165 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1283331009166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1283331009167 ribonuclease D; Region: rnd; TIGR01388 1283331009168 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1283331009169 catalytic site [active] 1283331009170 putative active site [active] 1283331009171 putative substrate binding site [chemical binding]; other site 1283331009172 HRDC domain; Region: HRDC; cl02578 1283331009173 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1283331009174 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1283331009175 active site residue [active] 1283331009176 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1283331009177 active site residue [active] 1283331009178 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1283331009179 dimerization interface [polypeptide binding]; other site 1283331009180 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1283331009181 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1283331009182 catalytic core [active] 1283331009183 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1283331009184 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1283331009185 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1283331009186 putative dimer interface [polypeptide binding]; other site 1283331009187 active site pocket [active] 1283331009188 putative cataytic base [active] 1283331009189 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1283331009190 homotrimer interface [polypeptide binding]; other site 1283331009191 Walker A motif; other site 1283331009192 GTP binding site [chemical binding]; other site 1283331009193 Walker B motif; other site 1283331009194 cobyric acid synthase; Provisional; Region: PRK00784 1283331009195 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1283331009196 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1283331009197 catalytic triad [active] 1283331009198 threonine-phosphate decarboxylase; Reviewed; Region: PRK05664 1283331009199 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1283331009200 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283331009201 catalytic residue [active] 1283331009202 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1283331009203 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1283331009204 FMN binding site [chemical binding]; other site 1283331009205 dimer interface [polypeptide binding]; other site 1283331009206 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1283331009207 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283331009208 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1283331009209 catalytic triad [active] 1283331009210 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 1283331009211 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331009212 N-terminal plug; other site 1283331009213 ligand-binding site [chemical binding]; other site 1283331009214 NAD-dependent deacetylase; Provisional; Region: PRK00481 1283331009215 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1283331009216 NAD+ binding site [chemical binding]; other site 1283331009217 substrate binding site [chemical binding]; other site 1283331009218 Zn binding site [ion binding]; other site 1283331009219 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1283331009220 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1283331009221 catalytic triad [active] 1283331009222 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1283331009223 NlpC/P60 family; Region: NLPC_P60; pfam00877 1283331009224 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1283331009225 NlpC/P60 family; Region: NLPC_P60; pfam00877 1283331009226 NAD-dependent deacetylase; Provisional; Region: PRK00481 1283331009227 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1283331009228 NAD+ binding site [chemical binding]; other site 1283331009229 substrate binding site [chemical binding]; other site 1283331009230 Zn binding site [ion binding]; other site 1283331009231 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1283331009232 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1283331009233 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1283331009234 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1283331009235 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1283331009236 Ligand Binding Site [chemical binding]; other site 1283331009237 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1283331009238 hypothetical protein; Provisional; Region: PRK04860 1283331009239 SprT homologues; Region: SprT; cl01182 1283331009240 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1283331009241 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1283331009242 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1283331009243 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283331009244 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283331009245 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1283331009246 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1283331009247 ATP cone domain; Region: ATP-cone; pfam03477 1283331009248 ATP cone domain; Region: ATP-cone; pfam03477 1283331009249 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1283331009250 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1283331009251 protein-splicing catalytic site; other site 1283331009252 thioester formation/cholesterol transfer; other site 1283331009253 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1283331009254 R2 peptide binding site; other site 1283331009255 catalytic residues [active] 1283331009256 active site 1283331009257 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1283331009258 dimer interface [polypeptide binding]; other site 1283331009259 putative radical transfer pathway; other site 1283331009260 diiron center [ion binding]; other site 1283331009261 tyrosyl radical; other site 1283331009262 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283331009263 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283331009264 Transposase IS200 like; Region: Y1_Tnp; cl00848 1283331009265 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1283331009266 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1283331009267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331009268 S-adenosylmethionine binding site [chemical binding]; other site 1283331009269 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 1283331009270 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331009271 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331009272 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1283331009273 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1283331009274 TOBE domain; Region: TOBE; cl01440 1283331009275 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1283331009276 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283331009277 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1283331009278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331009279 Walker A motif; other site 1283331009280 ATP binding site [chemical binding]; other site 1283331009281 Walker B motif; other site 1283331009282 arginine finger; other site 1283331009283 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331009284 Integrase core domain; Region: rve_3; pfam13683 1283331009285 Integral membrane protein TerC family; Region: TerC; cl10468 1283331009286 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 1283331009287 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1283331009288 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283331009289 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283331009290 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331009291 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331009292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283331009293 Integrase core domain; Region: rve; pfam00665 1283331009294 Integrase core domain; Region: rve_3; pfam13683 1283331009295 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331009296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331009297 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1283331009298 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1283331009299 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283331009300 trimer interface; other site 1283331009301 sugar binding site [chemical binding]; other site 1283331009302 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283331009303 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283331009304 Cytochrome c; Region: Cytochrom_C; pfam00034 1283331009305 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1283331009306 TrkA-N domain; Region: TrkA_N; pfam02254 1283331009307 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1283331009308 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1283331009309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283331009310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283331009311 DNA binding site [nucleotide binding] 1283331009312 domain linker motif; other site 1283331009313 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1283331009314 putative dimerization interface [polypeptide binding]; other site 1283331009315 putative ligand binding site [chemical binding]; other site 1283331009316 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1283331009317 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1283331009318 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1283331009319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009320 putative substrate translocation pore; other site 1283331009321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009322 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283331009323 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1283331009324 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283331009325 Right handed beta helix region; Region: Beta_helix; pfam13229 1283331009326 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1283331009327 Transposase; Region: HTH_Tnp_1; cl17663 1283331009328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009330 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331009331 dimerization interface [polypeptide binding]; other site 1283331009332 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283331009333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009334 putative substrate translocation pore; other site 1283331009335 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1283331009336 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 1283331009337 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283331009338 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283331009339 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1283331009340 dimer interface [polypeptide binding]; other site 1283331009341 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1283331009342 active site 1283331009343 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1283331009344 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1283331009345 putative NAD(P) binding site [chemical binding]; other site 1283331009346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009348 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1283331009349 putative substrate binding pocket [chemical binding]; other site 1283331009350 putative dimerization interface [polypeptide binding]; other site 1283331009351 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1283331009352 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283331009353 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331009354 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1283331009355 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1283331009356 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1283331009357 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1283331009358 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331009359 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331009360 active site 1283331009361 catalytic tetrad [active] 1283331009362 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1283331009363 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283331009364 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283331009365 DNA binding site [nucleotide binding] 1283331009366 domain linker motif; other site 1283331009367 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1283331009368 putative dimerization interface [polypeptide binding]; other site 1283331009369 putative ligand binding site [chemical binding]; other site 1283331009370 hypothetical protein; Provisional; Region: PRK06847 1283331009371 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 1283331009372 substrate binding pocket [chemical binding]; other site 1283331009373 substrate-Mg2+ binding site; other site 1283331009374 aspartate-rich region 1; other site 1283331009375 aspartate-rich region 2; other site 1283331009376 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331009377 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1283331009378 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1283331009379 active site 1283331009380 metal binding site [ion binding]; metal-binding site 1283331009381 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 1283331009382 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1283331009383 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 1283331009384 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1283331009385 oxidoreductase; Validated; Region: PRK05717 1283331009386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331009387 NAD(P) binding site [chemical binding]; other site 1283331009388 active site 1283331009389 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1283331009390 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1283331009391 homodimer interface [polypeptide binding]; other site 1283331009392 substrate-cofactor binding pocket; other site 1283331009393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331009394 catalytic residue [active] 1283331009395 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1283331009396 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1283331009397 active site 1283331009398 tetramer interface [polypeptide binding]; other site 1283331009399 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331009400 active site 1283331009401 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1283331009402 Colicin V production protein; Region: Colicin_V; cl00567 1283331009403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 1283331009404 Sporulation related domain; Region: SPOR; pfam05036 1283331009405 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1283331009406 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283331009407 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1283331009408 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1283331009409 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1283331009410 active site 1283331009411 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1283331009412 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1283331009413 dimerization interface 3.5A [polypeptide binding]; other site 1283331009414 active site 1283331009415 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1283331009416 FimV N-terminal domain; Region: FimV_core; TIGR03505 1283331009417 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1283331009418 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 1283331009419 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283331009420 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1283331009421 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283331009422 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1283331009423 tartrate dehydrogenase; Region: TTC; TIGR02089 1283331009424 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1283331009425 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1283331009426 substrate binding site [chemical binding]; other site 1283331009427 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1283331009428 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1283331009429 substrate binding site [chemical binding]; other site 1283331009430 ligand binding site [chemical binding]; other site 1283331009431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283331009434 dimerization interface [polypeptide binding]; other site 1283331009435 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1283331009436 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1283331009437 putative dimer interface [polypeptide binding]; other site 1283331009438 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1283331009439 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1283331009440 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1283331009441 FMN binding site [chemical binding]; other site 1283331009442 active site 1283331009443 catalytic residues [active] 1283331009444 substrate binding site [chemical binding]; other site 1283331009445 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1283331009446 active site 1283331009447 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1283331009448 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1283331009449 active site 1283331009450 intersubunit interface [polypeptide binding]; other site 1283331009451 catalytic residue [active] 1283331009452 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1283331009453 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331009454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331009455 active site 1283331009456 phosphorylation site [posttranslational modification] 1283331009457 intermolecular recognition site; other site 1283331009458 dimerization interface [polypeptide binding]; other site 1283331009459 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1283331009460 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1283331009461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331009462 ATP binding site [chemical binding]; other site 1283331009463 Mg2+ binding site [ion binding]; other site 1283331009464 G-X-G motif; other site 1283331009465 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1283331009466 anti sigma factor interaction site; other site 1283331009467 regulatory phosphorylation site [posttranslational modification]; other site 1283331009468 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283331009469 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 1283331009470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331009471 Walker A motif; other site 1283331009472 ATP binding site [chemical binding]; other site 1283331009473 Walker B motif; other site 1283331009474 arginine finger; other site 1283331009475 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1283331009476 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1283331009477 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1283331009478 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1283331009479 Arc-like DNA binding domain; Region: Arc; pfam03869 1283331009480 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1283331009481 MgtE intracellular N domain; Region: MgtE_N; smart00924 1283331009482 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1283331009483 Divalent cation transporter; Region: MgtE; cl00786 1283331009484 Global regulator protein family; Region: CsrA; cl00670 1283331009485 aspartate kinase; Reviewed; Region: PRK06635 1283331009486 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1283331009487 putative nucleotide binding site [chemical binding]; other site 1283331009488 putative catalytic residues [active] 1283331009489 putative Mg ion binding site [ion binding]; other site 1283331009490 putative aspartate binding site [chemical binding]; other site 1283331009491 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1283331009492 putative allosteric regulatory site; other site 1283331009493 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1283331009494 putative allosteric regulatory residue; other site 1283331009495 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1283331009496 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1283331009497 motif 1; other site 1283331009498 active site 1283331009499 motif 2; other site 1283331009500 motif 3; other site 1283331009501 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1283331009502 DHHA1 domain; Region: DHHA1; pfam02272 1283331009503 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1283331009504 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1283331009505 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1283331009506 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1283331009507 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1283331009508 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283331009509 inhibitor-cofactor binding pocket; inhibition site 1283331009510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331009511 catalytic residue [active] 1283331009512 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1283331009513 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1283331009514 conserved cys residue [active] 1283331009515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331009516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331009517 acetyl-CoA synthetase; Provisional; Region: PRK00174 1283331009518 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1283331009519 active site 1283331009520 CoA binding site [chemical binding]; other site 1283331009521 acyl-activating enzyme (AAE) consensus motif; other site 1283331009522 AMP binding site [chemical binding]; other site 1283331009523 acetate binding site [chemical binding]; other site 1283331009524 phosphate acetyltransferase; Reviewed; Region: PRK05632 1283331009525 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283331009526 DRTGG domain; Region: DRTGG; pfam07085 1283331009527 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1283331009528 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1283331009529 propionate/acetate kinase; Provisional; Region: PRK12379 1283331009530 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1283331009531 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1283331009532 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1283331009533 dinuclear metal binding motif [ion binding]; other site 1283331009534 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1283331009535 cofactor binding site; other site 1283331009536 metal binding site [ion binding]; metal-binding site 1283331009537 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1283331009538 aromatic arch; other site 1283331009539 DCoH dimer interaction site [polypeptide binding]; other site 1283331009540 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1283331009541 DCoH tetramer interaction site [polypeptide binding]; other site 1283331009542 substrate binding site [chemical binding]; other site 1283331009543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009544 putative MFS family transporter protein; Provisional; Region: PRK03633 1283331009545 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1283331009546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331009547 active site 1283331009548 motif I; other site 1283331009549 motif II; other site 1283331009550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331009551 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1283331009552 glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398 1283331009553 active site 1283331009554 homotetramer interface [polypeptide binding]; other site 1283331009555 hypothetical protein; Provisional; Region: PRK09256 1283331009556 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1283331009557 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1283331009558 Dienelactone hydrolase family; Region: DLH; pfam01738 1283331009559 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1283331009560 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1283331009561 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1283331009562 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1283331009563 dimer interface [polypeptide binding]; other site 1283331009564 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1283331009565 active site 1283331009566 Fe binding site [ion binding]; other site 1283331009567 BON domain; Region: BON; pfam04972 1283331009568 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 1283331009569 putative hydrophobic ligand binding site [chemical binding]; other site 1283331009570 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1283331009571 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1283331009572 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283331009573 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 1283331009574 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283331009575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331009576 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1283331009577 Walker A/P-loop; other site 1283331009578 ATP binding site [chemical binding]; other site 1283331009579 Q-loop/lid; other site 1283331009580 ABC transporter signature motif; other site 1283331009581 Walker B; other site 1283331009582 D-loop; other site 1283331009583 H-loop/switch region; other site 1283331009584 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1283331009585 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1283331009586 catalytic residues [active] 1283331009587 BolA-like protein; Region: BolA; pfam01722 1283331009588 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1283331009589 fumarate hydratase; Provisional; Region: PRK12425 1283331009590 Class II fumarases; Region: Fumarase_classII; cd01362 1283331009591 active site 1283331009592 tetramer interface [polypeptide binding]; other site 1283331009593 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1283331009594 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1283331009595 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1283331009596 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1283331009597 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1283331009598 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283331009599 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1283331009600 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1283331009601 MarR family; Region: MarR_2; cl17246 1283331009602 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1283331009603 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1283331009604 active site 1283331009605 dimer interface [polypeptide binding]; other site 1283331009606 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1283331009607 Ligand Binding Site [chemical binding]; other site 1283331009608 Molecular Tunnel; other site 1283331009609 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1283331009610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1283331009611 Coenzyme A binding pocket [chemical binding]; other site 1283331009612 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1283331009613 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1283331009614 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1283331009615 putative oligomer interface [polypeptide binding]; other site 1283331009616 putative active site [active] 1283331009617 metal binding site [ion binding]; metal-binding site 1283331009618 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1283331009619 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1283331009620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331009621 dimer interface [polypeptide binding]; other site 1283331009622 phosphorylation site [posttranslational modification] 1283331009623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331009624 ATP binding site [chemical binding]; other site 1283331009625 Mg2+ binding site [ion binding]; other site 1283331009626 G-X-G motif; other site 1283331009627 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331009628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331009629 active site 1283331009630 phosphorylation site [posttranslational modification] 1283331009631 intermolecular recognition site; other site 1283331009632 dimerization interface [polypeptide binding]; other site 1283331009633 hypothetical protein; Provisional; Region: PRK00304 1283331009634 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1283331009635 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1283331009636 Domain of unknown function DUF21; Region: DUF21; pfam01595 1283331009637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1283331009638 Transporter associated domain; Region: CorC_HlyC; smart01091 1283331009639 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1283331009640 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1283331009641 Na binding site [ion binding]; other site 1283331009642 Predicted membrane protein [Function unknown]; Region: COG3162 1283331009643 Predicted membrane protein [Function unknown]; Region: COG3205 1283331009644 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1283331009645 VacJ like lipoprotein; Region: VacJ; cl01073 1283331009646 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1283331009647 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1283331009648 putative acyl-acceptor binding pocket; other site 1283331009649 septum formation inhibitor; Reviewed; Region: minC; PRK00339 1283331009650 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1283331009651 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1283331009652 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1283331009653 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1283331009654 Switch I; other site 1283331009655 Switch II; other site 1283331009656 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1283331009657 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1283331009658 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1283331009659 active site 1283331009660 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1283331009661 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1283331009662 active site 1283331009663 metal binding site [ion binding]; metal-binding site 1283331009664 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1283331009665 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1283331009666 NAD(P) binding site [chemical binding]; other site 1283331009667 carboxy-terminal protease; Provisional; Region: PRK11186 1283331009668 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1283331009669 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1283331009670 protein binding site [polypeptide binding]; other site 1283331009671 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1283331009672 Catalytic dyad [active] 1283331009673 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1283331009674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331009675 non-specific DNA binding site [nucleotide binding]; other site 1283331009676 salt bridge; other site 1283331009677 sequence-specific DNA binding site [nucleotide binding]; other site 1283331009678 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1283331009679 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1283331009680 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1283331009681 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283331009682 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1283331009683 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1283331009684 Na binding site [ion binding]; other site 1283331009685 PAS domain; Region: PAS; smart00091 1283331009686 PAS fold; Region: PAS_7; pfam12860 1283331009687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331009688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331009689 dimer interface [polypeptide binding]; other site 1283331009690 phosphorylation site [posttranslational modification] 1283331009691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331009692 ATP binding site [chemical binding]; other site 1283331009693 Mg2+ binding site [ion binding]; other site 1283331009694 G-X-G motif; other site 1283331009695 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331009696 Predicted membrane protein [Function unknown]; Region: COG3174 1283331009697 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1283331009698 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1283331009699 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 1283331009700 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1283331009701 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 1283331009702 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1283331009703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331009704 S-adenosylmethionine binding site [chemical binding]; other site 1283331009705 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1283331009706 ATP binding site [chemical binding]; other site 1283331009707 active site 1283331009708 substrate binding site [chemical binding]; other site 1283331009709 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1283331009710 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1283331009711 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1283331009712 dimer interface [polypeptide binding]; other site 1283331009713 active site 1283331009714 catalytic residue [active] 1283331009715 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1283331009716 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1283331009717 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1283331009718 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1283331009719 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1283331009720 catalytic triad [active] 1283331009721 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1283331009722 CPxP motif; other site 1283331009723 Peptidase family M48; Region: Peptidase_M48; cl12018 1283331009724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1283331009725 binding surface 1283331009726 TPR motif; other site 1283331009727 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1283331009728 quinolinate synthetase; Provisional; Region: PRK09375 1283331009729 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1283331009730 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1283331009731 transmembrane helices; other site 1283331009732 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 1283331009733 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1283331009734 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1283331009735 putative NAD(P) binding site [chemical binding]; other site 1283331009736 putative substrate binding site [chemical binding]; other site 1283331009737 catalytic Zn binding site [ion binding]; other site 1283331009738 structural Zn binding site [ion binding]; other site 1283331009739 dimer interface [polypeptide binding]; other site 1283331009740 classical (c) SDRs; Region: SDR_c; cd05233 1283331009741 NAD(P) binding site [chemical binding]; other site 1283331009742 active site 1283331009743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009745 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283331009746 putative effector binding pocket; other site 1283331009747 putative dimerization interface [polypeptide binding]; other site 1283331009748 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1283331009749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009750 putative substrate translocation pore; other site 1283331009751 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009753 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283331009754 putative effector binding pocket; other site 1283331009755 putative dimerization interface [polypeptide binding]; other site 1283331009756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331009757 FeS/SAM binding site; other site 1283331009758 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1283331009759 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1283331009760 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1283331009761 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1283331009762 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1283331009763 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331009764 catalytic loop [active] 1283331009765 iron binding site [ion binding]; other site 1283331009766 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1283331009767 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1283331009768 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283331009769 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1283331009770 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283331009771 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283331009772 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1283331009773 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1283331009774 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331009775 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331009776 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331009777 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1283331009778 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283331009779 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 1283331009780 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1283331009781 VirB7 interaction site; other site 1283331009782 conjugal transfer protein TrbF; Provisional; Region: PRK13872 1283331009783 conjugal transfer protein TrbL; Provisional; Region: PRK13875 1283331009784 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 1283331009785 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 1283331009786 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 1283331009787 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 1283331009788 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1283331009789 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1283331009790 Walker A motif; other site 1283331009791 ATP binding site [chemical binding]; other site 1283331009792 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1283331009793 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 1283331009794 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 1283331009795 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 1283331009796 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1283331009797 ATP binding site [chemical binding]; other site 1283331009798 Walker A motif; other site 1283331009799 hexamer interface [polypeptide binding]; other site 1283331009800 Walker B motif; other site 1283331009801 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 1283331009802 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1283331009803 Walker A motif; other site 1283331009804 ATP binding site [chemical binding]; other site 1283331009805 Walker B motif; other site 1283331009806 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009808 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283331009809 dimerization interface [polypeptide binding]; other site 1283331009810 substrate binding pocket [chemical binding]; other site 1283331009811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009812 putative substrate translocation pore; other site 1283331009813 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283331009814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283331009816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331009817 Major royal jelly protein; Region: MRJP; pfam03022 1283331009818 SnoaL-like domain; Region: SnoaL_2; pfam12680 1283331009819 SnoaL-like domain; Region: SnoaL_2; pfam12680 1283331009820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283331009821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331009822 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1283331009823 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283331009824 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331009827 dimerization interface [polypeptide binding]; other site 1283331009828 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009830 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283331009831 dimerization interface [polypeptide binding]; other site 1283331009832 substrate binding pocket [chemical binding]; other site 1283331009833 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283331009834 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283331009835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009836 putative substrate translocation pore; other site 1283331009837 Beta-lactamase; Region: Beta-lactamase; pfam00144 1283331009838 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1283331009839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009841 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1283331009842 putative dimerization interface [polypeptide binding]; other site 1283331009843 putative effector binding pocket; other site 1283331009844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331009845 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283331009846 putative substrate translocation pore; other site 1283331009847 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331009848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331009849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331009850 dimerization interface [polypeptide binding]; other site 1283331009851 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 1283331009852 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 1283331009853 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 1283331009854 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1283331009855 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 1283331009856 ParA-like protein; Provisional; Region: PHA02518 1283331009857 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283331009858 P-loop; other site 1283331009859 Magnesium ion binding site [ion binding]; other site 1283331009860 Replication initiator protein A; Region: RPA; pfam10134 1283331009861 Helix-turn-helix domain; Region: HTH_17; cl17695 1283331009862 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 1283331009863 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 1283331009864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1283331009865 sequence-specific DNA binding site [nucleotide binding]; other site 1283331009866 salt bridge; other site 1283331009867 Protein of unknown function (DUF736); Region: DUF736; cl02303 1283331009868 hypothetical protein; Reviewed; Region: PRK00024 1283331009869 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1283331009870 MPN+ (JAMM) motif; other site 1283331009871 Zinc-binding site [ion binding]; other site 1283331009872 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1283331009873 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1283331009874 cofactor binding site; other site 1283331009875 DNA binding site [nucleotide binding] 1283331009876 substrate interaction site [chemical binding]; other site 1283331009877 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1283331009878 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1283331009879 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1283331009880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331009881 ATP binding site [chemical binding]; other site 1283331009882 G-X-G motif; other site 1283331009883 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1283331009884 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1283331009885 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1283331009886 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1283331009887 active site 1283331009888 Int/Topo IB signature motif; other site 1283331009889 DNA binding site [nucleotide binding] 1283331009890 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331009891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331009892 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1283331009893 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1283331009894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283331009895 DNA-binding site [nucleotide binding]; DNA binding site 1283331009896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283331009897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331009898 homodimer interface [polypeptide binding]; other site 1283331009899 catalytic residue [active] 1283331009900 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283331009901 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283331009902 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1283331009903 oligomeric interface; other site 1283331009904 putative active site [active] 1283331009905 homodimer interface [polypeptide binding]; other site 1283331009906 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1283331009907 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1283331009908 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1283331009909 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1283331009910 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1283331009911 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 1283331009912 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1283331009913 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 1283331009914 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1283331009915 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1283331009916 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1283331009917 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1283331009918 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1283331009919 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1283331009920 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1283331009921 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1283331009922 catalytic residues [active] 1283331009923 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1283331009924 active site 1283331009925 ATP binding site [chemical binding]; other site 1283331009926 substrate binding site [chemical binding]; other site 1283331009927 activation loop (A-loop); other site 1283331009928 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1283331009929 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1283331009930 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1283331009931 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1283331009932 PemK-like protein; Region: PemK; pfam02452 1283331009933 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1283331009934 Homeodomain-like domain; Region: HTH_23; pfam13384 1283331009935 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331009936 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331009937 Winged helix-turn helix; Region: HTH_33; pfam13592 1283331009938 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331009939 Transposase domain (DUF772); Region: DUF772; pfam05598 1283331009940 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283331009941 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283331009942 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1283331009943 Integrase core domain; Region: rve; pfam00665 1283331009944 Integrase core domain; Region: rve_3; pfam13683 1283331009945 transposase/IS protein; Provisional; Region: PRK09183 1283331009946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331009947 Walker A motif; other site 1283331009948 ATP binding site [chemical binding]; other site 1283331009949 Walker B motif; other site 1283331009950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1283331009951 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1283331009952 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1283331009953 DNA binding site [nucleotide binding] 1283331009954 DNA-binding interface [nucleotide binding]; DNA binding site 1283331009955 domain linker motif; other site 1283331009956 Integrase core domain; Region: rve; pfam00665 1283331009957 Integrase core domain; Region: rve_3; cl15866 1283331009958 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1283331009959 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1283331009960 Fic family protein [Function unknown]; Region: COG3177 1283331009961 Fic/DOC family; Region: Fic; pfam02661 1283331009962 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1283331009963 Putative helicase; Region: TraI_2; pfam07514 1283331009964 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1283331009965 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1283331009966 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1283331009967 active site 1283331009968 catalytic residues [active] 1283331009969 DNA binding site [nucleotide binding] 1283331009970 Int/Topo IB signature motif; other site 1283331009971 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1283331009972 Ligand Binding Site [chemical binding]; other site 1283331009973 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1283331009974 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331009975 FeS/SAM binding site; other site 1283331009976 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1283331009977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283331009978 binding surface 1283331009979 TPR motif; other site 1283331009980 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283331009981 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283331009982 ligand binding site [chemical binding]; other site 1283331009983 translocation protein TolB; Provisional; Region: tolB; PRK00178 1283331009984 TolB amino-terminal domain; Region: TolB_N; pfam04052 1283331009985 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1283331009986 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1283331009987 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1283331009988 TolA protein; Region: tolA_full; TIGR02794 1283331009989 TolA protein; Region: tolA_full; TIGR02794 1283331009990 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1283331009991 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283331009992 TolR protein; Region: tolR; TIGR02801 1283331009993 TolQ protein; Region: tolQ; TIGR02796 1283331009994 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1283331009995 active site 1283331009996 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1283331009997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331009998 Walker A motif; other site 1283331009999 ATP binding site [chemical binding]; other site 1283331010000 Walker B motif; other site 1283331010001 arginine finger; other site 1283331010002 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1283331010003 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1283331010004 RuvA N terminal domain; Region: RuvA_N; pfam01330 1283331010005 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1283331010006 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1283331010007 active site 1283331010008 putative DNA-binding cleft [nucleotide binding]; other site 1283331010009 dimer interface [polypeptide binding]; other site 1283331010010 hypothetical protein; Validated; Region: PRK00110 1283331010011 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1283331010012 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1283331010013 dimer interface [polypeptide binding]; other site 1283331010014 anticodon binding site; other site 1283331010015 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1283331010016 homodimer interface [polypeptide binding]; other site 1283331010017 motif 1; other site 1283331010018 active site 1283331010019 motif 2; other site 1283331010020 GAD domain; Region: GAD; pfam02938 1283331010021 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1283331010022 active site 1283331010023 motif 3; other site 1283331010024 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1283331010025 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1283331010026 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1283331010027 dimer interface [polypeptide binding]; other site 1283331010028 motif 1; other site 1283331010029 active site 1283331010030 motif 2; other site 1283331010031 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1283331010032 putative deacylase active site [active] 1283331010033 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1283331010034 active site 1283331010035 motif 3; other site 1283331010036 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1283331010037 anticodon binding site; other site 1283331010038 acylphosphatase; Provisional; Region: PRK14442 1283331010039 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1283331010040 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1283331010041 catalytic residues [active] 1283331010042 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1283331010043 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 1283331010044 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1283331010045 ArsC family; Region: ArsC; pfam03960 1283331010046 catalytic residues [active] 1283331010047 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1283331010048 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283331010049 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 1283331010050 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1283331010051 DNA replication initiation factor; Validated; Region: PRK05642 1283331010052 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1283331010053 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1283331010054 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1283331010055 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1283331010056 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1283331010057 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1283331010058 dimerization interface [polypeptide binding]; other site 1283331010059 putative ATP binding site [chemical binding]; other site 1283331010060 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1283331010061 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1283331010062 active site 1283331010063 substrate binding site [chemical binding]; other site 1283331010064 cosubstrate binding site; other site 1283331010065 catalytic site [active] 1283331010066 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1283331010067 RelB antitoxin; Region: RelB; cl01171 1283331010068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 1283331010069 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 1283331010070 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1283331010071 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1283331010072 homodimer interface [polypeptide binding]; other site 1283331010073 metal binding site [ion binding]; metal-binding site 1283331010074 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1283331010075 homodimer interface [polypeptide binding]; other site 1283331010076 active site 1283331010077 putative chemical substrate binding site [chemical binding]; other site 1283331010078 metal binding site [ion binding]; metal-binding site 1283331010079 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1283331010080 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1283331010081 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1283331010082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331010083 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 1283331010084 outer membrane receptor FepA; Provisional; Region: PRK13528 1283331010085 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331010086 N-terminal plug; other site 1283331010087 ligand-binding site [chemical binding]; other site 1283331010088 outer membrane receptor FepA; Provisional; Region: PRK13524 1283331010089 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331010090 N-terminal plug; other site 1283331010091 ligand-binding site [chemical binding]; other site 1283331010092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331010093 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331010094 dimerization interface [polypeptide binding]; other site 1283331010095 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1283331010096 dimer interface [polypeptide binding]; other site 1283331010097 phosphorylation site [posttranslational modification] 1283331010098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331010099 ATP binding site [chemical binding]; other site 1283331010100 Mg2+ binding site [ion binding]; other site 1283331010101 G-X-G motif; other site 1283331010102 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283331010103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331010104 active site 1283331010105 phosphorylation site [posttranslational modification] 1283331010106 intermolecular recognition site; other site 1283331010107 dimerization interface [polypeptide binding]; other site 1283331010108 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331010109 DNA binding site [nucleotide binding] 1283331010110 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1283331010111 HD domain; Region: HD_4; pfam13328 1283331010112 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1283331010113 synthetase active site [active] 1283331010114 NTP binding site [chemical binding]; other site 1283331010115 metal binding site [ion binding]; metal-binding site 1283331010116 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1283331010117 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1283331010118 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1283331010119 TRAM domain; Region: TRAM; pfam01938 1283331010120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331010121 S-adenosylmethionine binding site [chemical binding]; other site 1283331010122 cysteine synthase B; Region: cysM; TIGR01138 1283331010123 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1283331010124 dimer interface [polypeptide binding]; other site 1283331010125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331010126 catalytic residue [active] 1283331010127 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1283331010128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331010129 dimerization interface [polypeptide binding]; other site 1283331010130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331010131 dimer interface [polypeptide binding]; other site 1283331010132 phosphorylation site [posttranslational modification] 1283331010133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331010134 ATP binding site [chemical binding]; other site 1283331010135 Mg2+ binding site [ion binding]; other site 1283331010136 G-X-G motif; other site 1283331010137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331010138 active site 1283331010139 phosphorylation site [posttranslational modification] 1283331010140 intermolecular recognition site; other site 1283331010141 dimerization interface [polypeptide binding]; other site 1283331010142 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1283331010143 putative binding surface; other site 1283331010144 active site 1283331010145 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1283331010146 active site 1283331010147 DNA polymerase IV; Validated; Region: PRK02406 1283331010148 DNA binding site [nucleotide binding] 1283331010149 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1283331010150 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1283331010151 catalytic residues [active] 1283331010152 catalytic nucleophile [active] 1283331010153 Recombinase; Region: Recombinase; pfam07508 1283331010154 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1283331010155 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 1283331010156 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1283331010157 active site 1283331010158 metal binding site [ion binding]; metal-binding site 1283331010159 interdomain interaction site; other site 1283331010160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331010161 Walker A/P-loop; other site 1283331010162 ATP binding site [chemical binding]; other site 1283331010163 Q-loop/lid; other site 1283331010164 AntA/AntB antirepressor; Region: AntA; pfam08346 1283331010165 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1283331010166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1283331010167 non-specific DNA binding site [nucleotide binding]; other site 1283331010168 salt bridge; other site 1283331010169 sequence-specific DNA binding site [nucleotide binding]; other site 1283331010170 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1283331010171 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1283331010172 Domain of unknown function (DUF955); Region: DUF955; cl01076 1283331010173 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1283331010174 P2 prophage; not known if it is functional in this host 1283331010175 tail protein; Provisional; Region: D; PHA02561 1283331010176 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1283331010177 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1283331010178 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1283331010179 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1283331010180 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1283331010181 major tail tube protein; Provisional; Region: FII; PHA02600 1283331010182 major tail sheath protein; Provisional; Region: FI; PHA02560 1283331010183 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1283331010184 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 1283331010185 Baseplate J-like protein; Region: Baseplate_J; cl01294 1283331010186 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1283331010187 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1283331010188 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1283331010189 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1283331010190 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1283331010191 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1283331010192 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1283331010193 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 1283331010194 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 1283331010195 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1283331010196 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1283331010197 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1283331010198 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1283331010199 capsid protein; Provisional; Region: N; PHA02538 1283331010200 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1283331010201 terminase ATPase subunit; Provisional; Region: P; PHA02535 1283331010202 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1283331010203 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1283331010204 portal vertex protein; Provisional; Region: Q; PHA02536 1283331010205 Phage portal protein; Region: Phage_portal; pfam04860 1283331010206 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1283331010207 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1283331010208 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1283331010209 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331010210 FeS/SAM binding site; other site 1283331010211 TRAM domain; Region: TRAM; cl01282 1283331010212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1283331010213 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1283331010214 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1283331010215 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1283331010216 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1283331010217 conserved cys residue [active] 1283331010218 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1283331010219 putative active site [active] 1283331010220 catalytic site [active] 1283331010221 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1283331010222 PLD-like domain; Region: PLDc_2; pfam13091 1283331010223 putative active site [active] 1283331010224 catalytic site [active] 1283331010225 Beta-lactamase; Region: Beta-lactamase; pfam00144 1283331010226 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1283331010227 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1283331010228 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1283331010229 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1283331010230 putative acyl-acceptor binding pocket; other site 1283331010231 Protein of unknown function, DUF479; Region: DUF479; cl01203 1283331010232 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331010233 dimerization interface [polypeptide binding]; other site 1283331010234 putative DNA binding site [nucleotide binding]; other site 1283331010235 putative Zn2+ binding site [ion binding]; other site 1283331010236 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1283331010237 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1283331010238 FMN binding site [chemical binding]; other site 1283331010239 active site 1283331010240 substrate binding site [chemical binding]; other site 1283331010241 catalytic residue [active] 1283331010242 superoxide dismutase; Provisional; Region: PRK10543 1283331010243 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1283331010244 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1283331010245 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1283331010246 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331010247 metal binding site [ion binding]; metal-binding site 1283331010248 active site 1283331010249 I-site; other site 1283331010250 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283331010251 Imelysin; Region: Peptidase_M75; cl09159 1283331010252 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1283331010253 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1283331010254 Imelysin; Region: Peptidase_M75; cl09159 1283331010255 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 1283331010256 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1283331010257 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1283331010258 Surface antigen; Region: Bac_surface_Ag; pfam01103 1283331010259 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1283331010260 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1283331010261 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1283331010262 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1283331010263 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283331010264 ligand binding site [chemical binding]; other site 1283331010265 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331010266 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331010267 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283331010268 dimerization interface [polypeptide binding]; other site 1283331010269 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 1283331010270 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1283331010271 putative NAD(P) binding site [chemical binding]; other site 1283331010272 substrate binding site [chemical binding]; other site 1283331010273 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1283331010274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331010275 S-adenosylmethionine binding site [chemical binding]; other site 1283331010276 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1283331010277 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283331010278 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283331010279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331010280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331010281 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283331010282 putative effector binding pocket; other site 1283331010283 putative dimerization interface [polypeptide binding]; other site 1283331010284 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331010285 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331010286 active site 1283331010287 catalytic tetrad [active] 1283331010288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331010289 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331010290 active site 1283331010291 catalytic tetrad [active] 1283331010292 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1283331010293 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1283331010294 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1283331010295 active site 1283331010296 trimer interface [polypeptide binding]; other site 1283331010297 dimer interface [polypeptide binding]; other site 1283331010298 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1283331010299 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1283331010300 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1283331010301 shikimate binding site; other site 1283331010302 NAD(P) binding site [chemical binding]; other site 1283331010303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283331010304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331010305 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283331010306 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1283331010307 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1283331010308 dimer interface [polypeptide binding]; other site 1283331010309 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1283331010310 active site 1283331010311 Fe binding site [ion binding]; other site 1283331010312 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331010313 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331010314 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331010315 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331010316 active site 1283331010317 catalytic tetrad [active] 1283331010318 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1283331010319 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1283331010320 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1283331010321 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1283331010322 tetramer interface [polypeptide binding]; other site 1283331010323 active site 1283331010324 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1283331010325 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283331010326 dimer interface [polypeptide binding]; other site 1283331010327 active site 1283331010328 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1283331010329 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1283331010330 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1283331010331 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283331010332 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283331010333 Predicted ATPase [General function prediction only]; Region: COG1485 1283331010334 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1283331010335 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1283331010336 heterodimer interface [polypeptide binding]; other site 1283331010337 active site 1283331010338 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1283331010339 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1283331010340 active site 1283331010341 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1283331010342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331010343 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331010344 dimerization interface [polypeptide binding]; other site 1283331010345 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1283331010346 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1283331010347 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1283331010348 putative active site [active] 1283331010349 putative substrate binding site [chemical binding]; other site 1283331010350 putative cosubstrate binding site; other site 1283331010351 catalytic site [active] 1283331010352 exonuclease I; Provisional; Region: sbcB; PRK11779 1283331010353 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1283331010354 active site 1283331010355 catalytic site [active] 1283331010356 substrate binding site [chemical binding]; other site 1283331010357 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1283331010358 RDD family; Region: RDD; pfam06271 1283331010359 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1283331010360 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1283331010361 MoxR-like ATPases [General function prediction only]; Region: COG0714 1283331010362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331010363 Walker A motif; other site 1283331010364 ATP binding site [chemical binding]; other site 1283331010365 Walker B motif; other site 1283331010366 arginine finger; other site 1283331010367 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1283331010368 Protein of unknown function DUF58; Region: DUF58; pfam01882 1283331010369 PilZ domain; Region: PilZ; pfam07238 1283331010370 universal stress protein UspE; Provisional; Region: PRK11175 1283331010371 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331010372 Ligand Binding Site [chemical binding]; other site 1283331010373 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331010374 Ligand Binding Site [chemical binding]; other site 1283331010375 pyruvate kinase; Provisional; Region: PRK05826 1283331010376 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283331010377 domain interfaces; other site 1283331010378 active site 1283331010379 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331010380 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331010381 metal binding site [ion binding]; metal-binding site 1283331010382 active site 1283331010383 I-site; other site 1283331010384 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1283331010385 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1283331010386 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1283331010387 homodimer interaction site [polypeptide binding]; other site 1283331010388 cofactor binding site; other site 1283331010389 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1283331010390 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1283331010391 FAD binding pocket [chemical binding]; other site 1283331010392 FAD binding motif [chemical binding]; other site 1283331010393 phosphate binding motif [ion binding]; other site 1283331010394 beta-alpha-beta structure motif; other site 1283331010395 NAD binding pocket [chemical binding]; other site 1283331010396 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1283331010397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331010398 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1283331010399 putative dimerization interface [polypeptide binding]; other site 1283331010400 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1283331010401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331010402 active site 1283331010403 phosphorylation site [posttranslational modification] 1283331010404 intermolecular recognition site; other site 1283331010405 dimerization interface [polypeptide binding]; other site 1283331010406 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283331010407 DNA binding residues [nucleotide binding] 1283331010408 dimerization interface [polypeptide binding]; other site 1283331010409 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1283331010410 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 1283331010411 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 1283331010412 XFP N-terminal domain; Region: XFP_N; pfam09364 1283331010413 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1283331010414 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1283331010415 Beta-Casp domain; Region: Beta-Casp; smart01027 1283331010416 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1283331010417 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1283331010418 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1283331010419 recombinase A; Provisional; Region: recA; PRK09354 1283331010420 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1283331010421 hexamer interface [polypeptide binding]; other site 1283331010422 Walker A motif; other site 1283331010423 ATP binding site [chemical binding]; other site 1283331010424 Walker B motif; other site 1283331010425 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1283331010426 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283331010427 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1283331010428 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1283331010429 putative dimer interface [polypeptide binding]; other site 1283331010430 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1283331010431 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1283331010432 putative dimer interface [polypeptide binding]; other site 1283331010433 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1283331010434 MutS domain I; Region: MutS_I; pfam01624 1283331010435 MutS domain II; Region: MutS_II; pfam05188 1283331010436 MutS domain III; Region: MutS_III; pfam05192 1283331010437 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1283331010438 Walker A/P-loop; other site 1283331010439 ATP binding site [chemical binding]; other site 1283331010440 Q-loop/lid; other site 1283331010441 ABC transporter signature motif; other site 1283331010442 Walker B; other site 1283331010443 D-loop; other site 1283331010444 H-loop/switch region; other site 1283331010445 Ferredoxin [Energy production and conversion]; Region: COG1146 1283331010446 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1283331010447 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283331010448 dimer interface [polypeptide binding]; other site 1283331010449 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1283331010450 putative CheW interface [polypeptide binding]; other site 1283331010451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331010452 PAS fold; Region: PAS_3; pfam08447 1283331010453 putative active site [active] 1283331010454 heme pocket [chemical binding]; other site 1283331010455 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1283331010456 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 1283331010457 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1283331010458 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331010459 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1283331010460 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331010461 DNA binding residues [nucleotide binding] 1283331010462 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1283331010463 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1283331010464 Peptidase family M23; Region: Peptidase_M23; pfam01551 1283331010465 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1283331010466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331010467 S-adenosylmethionine binding site [chemical binding]; other site 1283331010468 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1283331010469 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1283331010470 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1283331010471 Permutation of conserved domain; other site 1283331010472 active site 1283331010473 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1283331010474 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1283331010475 homotrimer interaction site [polypeptide binding]; other site 1283331010476 zinc binding site [ion binding]; other site 1283331010477 CDP-binding sites; other site 1283331010478 S-formylglutathione hydrolase; Region: PLN02442 1283331010479 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1283331010480 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1283331010481 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1283331010482 substrate binding site [chemical binding]; other site 1283331010483 catalytic Zn binding site [ion binding]; other site 1283331010484 NAD binding site [chemical binding]; other site 1283331010485 structural Zn binding site [ion binding]; other site 1283331010486 dimer interface [polypeptide binding]; other site 1283331010487 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1283331010488 substrate binding site; other site 1283331010489 dimer interface; other site 1283331010490 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1283331010491 Septum formation initiator; Region: DivIC; cl17659 1283331010492 enolase; Provisional; Region: eno; PRK00077 1283331010493 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283331010494 dimer interface [polypeptide binding]; other site 1283331010495 metal binding site [ion binding]; metal-binding site 1283331010496 substrate binding pocket [chemical binding]; other site 1283331010497 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1283331010498 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1283331010499 CTP synthetase; Validated; Region: pyrG; PRK05380 1283331010500 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1283331010501 Catalytic site [active] 1283331010502 active site 1283331010503 UTP binding site [chemical binding]; other site 1283331010504 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1283331010505 active site 1283331010506 putative oxyanion hole; other site 1283331010507 catalytic triad [active] 1283331010508 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1283331010509 TilS substrate binding domain; Region: TilS; pfam09179 1283331010510 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1283331010511 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1283331010512 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1283331010513 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1283331010514 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1283331010515 putative active site [active] 1283331010516 putative PHP Thumb interface [polypeptide binding]; other site 1283331010517 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1283331010518 generic binding surface II; other site 1283331010519 generic binding surface I; other site 1283331010520 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1283331010521 RNA/DNA hybrid binding site [nucleotide binding]; other site 1283331010522 active site 1283331010523 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1283331010524 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1283331010525 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1283331010526 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1283331010527 active site 1283331010528 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1283331010529 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1283331010530 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1283331010531 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1283331010532 trimer interface [polypeptide binding]; other site 1283331010533 active site 1283331010534 UDP-GlcNAc binding site [chemical binding]; other site 1283331010535 lipid binding site [chemical binding]; lipid-binding site 1283331010536 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 1283331010537 periplasmic chaperone; Provisional; Region: PRK10780 1283331010538 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1283331010539 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283331010540 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283331010541 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283331010542 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283331010543 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283331010544 Surface antigen; Region: Bac_surface_Ag; pfam01103 1283331010545 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1283331010546 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1283331010547 active site 1283331010548 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1283331010549 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1283331010550 protein binding site [polypeptide binding]; other site 1283331010551 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1283331010552 putative substrate binding region [chemical binding]; other site 1283331010553 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1283331010554 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1283331010555 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1283331010556 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1283331010557 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1283331010558 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1283331010559 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1283331010560 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1283331010561 catalytic residue [active] 1283331010562 putative FPP diphosphate binding site; other site 1283331010563 putative FPP binding hydrophobic cleft; other site 1283331010564 dimer interface [polypeptide binding]; other site 1283331010565 putative IPP diphosphate binding site; other site 1283331010566 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1283331010567 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1283331010568 hinge region; other site 1283331010569 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1283331010570 putative nucleotide binding site [chemical binding]; other site 1283331010571 uridine monophosphate binding site [chemical binding]; other site 1283331010572 homohexameric interface [polypeptide binding]; other site 1283331010573 elongation factor Ts; Provisional; Region: tsf; PRK09377 1283331010574 UBA/TS-N domain; Region: UBA; pfam00627 1283331010575 Elongation factor TS; Region: EF_TS; pfam00889 1283331010576 Elongation factor TS; Region: EF_TS; pfam00889 1283331010577 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1283331010578 rRNA interaction site [nucleotide binding]; other site 1283331010579 S8 interaction site; other site 1283331010580 putative laminin-1 binding site; other site 1283331010581 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1283331010582 active site 1283331010583 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1283331010584 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1283331010585 metal binding triad; other site 1283331010586 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1283331010587 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283331010588 Zn2+ binding site [ion binding]; other site 1283331010589 Mg2+ binding site [ion binding]; other site 1283331010590 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1283331010591 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1283331010592 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1283331010593 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283331010594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331010595 homodimer interface [polypeptide binding]; other site 1283331010596 catalytic residue [active] 1283331010597 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1283331010598 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 1283331010599 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1283331010600 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1283331010601 ArsC family; Region: ArsC; pfam03960 1283331010602 putative catalytic residues [active] 1283331010603 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 1283331010604 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1283331010605 putative trimer interface [polypeptide binding]; other site 1283331010606 putative CoA binding site [chemical binding]; other site 1283331010607 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1283331010608 Aminotransferase class-V; Region: Aminotran_5; pfam00266 1283331010609 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283331010610 catalytic residue [active] 1283331010611 Fe-S metabolism associated domain; Region: SufE; cl00951 1283331010612 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1283331010613 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1283331010614 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1283331010615 putative ATP binding site [chemical binding]; other site 1283331010616 putative substrate interface [chemical binding]; other site 1283331010617 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1283331010618 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283331010619 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 1283331010620 Ligand binding site; other site 1283331010621 DXD motif; other site 1283331010622 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1283331010623 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1283331010624 metal binding site [ion binding]; metal-binding site 1283331010625 dimer interface [polypeptide binding]; other site 1283331010626 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1283331010627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1283331010628 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1283331010629 DNA-binding site [nucleotide binding]; DNA binding site 1283331010630 RNA-binding motif; other site 1283331010631 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 1283331010632 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1283331010633 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1283331010634 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1283331010635 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283331010636 Walker A/P-loop; other site 1283331010637 ATP binding site [chemical binding]; other site 1283331010638 Q-loop/lid; other site 1283331010639 ABC transporter signature motif; other site 1283331010640 Walker B; other site 1283331010641 D-loop; other site 1283331010642 H-loop/switch region; other site 1283331010643 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 1283331010644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331010645 S-adenosylmethionine binding site [chemical binding]; other site 1283331010646 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1283331010647 Protein of unknown function DUF72; Region: DUF72; cl00777 1283331010648 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1283331010649 Glycoprotease family; Region: Peptidase_M22; pfam00814 1283331010650 adenylate kinase; Reviewed; Region: adk; PRK00279 1283331010651 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1283331010652 AMP-binding site [chemical binding]; other site 1283331010653 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1283331010654 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1283331010655 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1283331010656 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1283331010657 putative ADP-ribose binding site [chemical binding]; other site 1283331010658 putative active site [active] 1283331010659 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283331010660 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1283331010661 Secretory lipase; Region: LIP; pfam03583 1283331010662 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1283331010663 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1283331010664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1283331010665 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1283331010666 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1283331010667 dimer interface [polypeptide binding]; other site 1283331010668 putative anticodon binding site; other site 1283331010669 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1283331010670 motif 1; other site 1283331010671 active site 1283331010672 motif 2; other site 1283331010673 motif 3; other site 1283331010674 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1283331010675 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1283331010676 RF-1 domain; Region: RF-1; pfam00472 1283331010677 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1283331010678 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1283331010679 putative metal binding site [ion binding]; other site 1283331010680 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1283331010681 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1283331010682 active site 1283331010683 FMN binding site [chemical binding]; other site 1283331010684 substrate binding site [chemical binding]; other site 1283331010685 homotetramer interface [polypeptide binding]; other site 1283331010686 catalytic residue [active] 1283331010687 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1283331010688 DHH family; Region: DHH; pfam01368 1283331010689 DHHA1 domain; Region: DHHA1; pfam02272 1283331010690 YaeQ protein; Region: YaeQ; pfam07152 1283331010691 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331010692 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331010693 metal binding site [ion binding]; metal-binding site 1283331010694 active site 1283331010695 I-site; other site 1283331010696 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1283331010697 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1283331010698 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1283331010699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331010700 catalytic residue [active] 1283331010701 homoserine dehydrogenase; Provisional; Region: PRK06349 1283331010702 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1283331010703 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1283331010704 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1283331010705 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1283331010706 dimerization domain [polypeptide binding]; other site 1283331010707 dimer interface [polypeptide binding]; other site 1283331010708 catalytic residues [active] 1283331010709 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1283331010710 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1283331010711 active site 1283331010712 Int/Topo IB signature motif; other site 1283331010713 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1283331010714 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1283331010715 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1283331010716 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1283331010717 RimM N-terminal domain; Region: RimM; pfam01782 1283331010718 PRC-barrel domain; Region: PRC; pfam05239 1283331010719 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1283331010720 signal recognition particle protein; Provisional; Region: PRK10867 1283331010721 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1283331010722 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1283331010723 P loop; other site 1283331010724 GTP binding site [chemical binding]; other site 1283331010725 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1283331010726 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1283331010727 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1283331010728 Domain of unknown function DUF21; Region: DUF21; pfam01595 1283331010729 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1283331010730 Transporter associated domain; Region: CorC_HlyC; smart01091 1283331010731 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1283331010732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331010733 ATP-grasp domain; Region: ATP-grasp; pfam02222 1283331010734 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1283331010735 putative active site [active] 1283331010736 putative CoA binding site [chemical binding]; other site 1283331010737 nudix motif; other site 1283331010738 metal binding site [ion binding]; metal-binding site 1283331010739 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1283331010740 nudix motif; other site 1283331010741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1283331010742 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1283331010743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1283331010744 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1283331010745 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1283331010746 dimerization interface [polypeptide binding]; other site 1283331010747 ATP binding site [chemical binding]; other site 1283331010748 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1283331010749 dimerization interface [polypeptide binding]; other site 1283331010750 ATP binding site [chemical binding]; other site 1283331010751 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1283331010752 putative active site [active] 1283331010753 catalytic triad [active] 1283331010754 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1283331010755 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331010756 substrate binding pocket [chemical binding]; other site 1283331010757 membrane-bound complex binding site; other site 1283331010758 hinge residues; other site 1283331010759 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283331010760 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283331010761 catalytic residue [active] 1283331010762 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1283331010763 nucleoside/Zn binding site; other site 1283331010764 dimer interface [polypeptide binding]; other site 1283331010765 catalytic motif [active] 1283331010766 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1283331010767 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1283331010768 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1283331010769 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1283331010770 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1283331010771 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331010772 catalytic loop [active] 1283331010773 iron binding site [ion binding]; other site 1283331010774 GMP synthase; Reviewed; Region: guaA; PRK00074 1283331010775 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1283331010776 AMP/PPi binding site [chemical binding]; other site 1283331010777 candidate oxyanion hole; other site 1283331010778 catalytic triad [active] 1283331010779 potential glutamine specificity residues [chemical binding]; other site 1283331010780 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1283331010781 ATP Binding subdomain [chemical binding]; other site 1283331010782 Ligand Binding sites [chemical binding]; other site 1283331010783 Dimerization subdomain; other site 1283331010784 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1283331010785 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1283331010786 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1283331010787 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1283331010788 active site 1283331010789 Family description; Region: UvrD_C_2; pfam13538 1283331010790 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1283331010791 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1283331010792 dimerization interface [polypeptide binding]; other site 1283331010793 NAD binding site [chemical binding]; other site 1283331010794 ligand binding site [chemical binding]; other site 1283331010795 catalytic site [active] 1283331010796 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1283331010797 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1283331010798 generic binding surface II; other site 1283331010799 generic binding surface I; other site 1283331010800 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1283331010801 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1283331010802 Peptidase family M23; Region: Peptidase_M23; pfam01551 1283331010803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1283331010804 Coenzyme A binding pocket [chemical binding]; other site 1283331010805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1283331010806 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1283331010807 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1283331010808 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1283331010809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331010810 S-adenosylmethionine binding site [chemical binding]; other site 1283331010811 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1283331010812 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1283331010813 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1283331010814 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1283331010815 intersubunit interface [polypeptide binding]; other site 1283331010816 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283331010817 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331010818 N-terminal plug; other site 1283331010819 ligand-binding site [chemical binding]; other site 1283331010820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331010821 transcriptional activator TtdR; Provisional; Region: PRK09801 1283331010822 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331010823 putative effector binding pocket; other site 1283331010824 dimerization interface [polypeptide binding]; other site 1283331010825 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1283331010826 hypothetical protein; Provisional; Region: PRK08204 1283331010827 active site 1283331010828 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1283331010829 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1283331010830 NAD(P) binding site [chemical binding]; other site 1283331010831 active site 1283331010832 hypothetical protein; Provisional; Region: PRK07877 1283331010833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331010834 putative transporter; Provisional; Region: PRK10504 1283331010835 putative substrate translocation pore; other site 1283331010836 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1283331010837 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1283331010838 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1283331010839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283331010840 DNA binding residues [nucleotide binding] 1283331010841 dimerization interface [polypeptide binding]; other site 1283331010842 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1283331010843 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1283331010844 dimer interface [polypeptide binding]; other site 1283331010845 active site 1283331010846 metal binding site [ion binding]; metal-binding site 1283331010847 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331010848 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1283331010849 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1283331010850 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1283331010851 FAD binding pocket [chemical binding]; other site 1283331010852 FAD binding motif [chemical binding]; other site 1283331010853 phosphate binding motif [ion binding]; other site 1283331010854 beta-alpha-beta structure motif; other site 1283331010855 NAD binding pocket [chemical binding]; other site 1283331010856 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1283331010857 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1283331010858 Trp docking motif [polypeptide binding]; other site 1283331010859 putative active site [active] 1283331010860 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331010861 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283331010862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331010863 substrate binding pocket [chemical binding]; other site 1283331010864 membrane-bound complex binding site; other site 1283331010865 hinge residues; other site 1283331010866 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331010867 N-terminal plug; other site 1283331010868 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1283331010869 ligand-binding site [chemical binding]; other site 1283331010870 2-isopropylmalate synthase; Validated; Region: PRK03739 1283331010871 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1283331010872 active site 1283331010873 catalytic residues [active] 1283331010874 metal binding site [ion binding]; metal-binding site 1283331010875 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1283331010876 DNA-specific endonuclease I; Provisional; Region: PRK15137 1283331010877 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1283331010878 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 1283331010879 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1283331010880 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1283331010881 C-N hydrolase family amidase; Provisional; Region: PRK10438 1283331010882 putative active site [active] 1283331010883 catalytic triad [active] 1283331010884 dimer interface [polypeptide binding]; other site 1283331010885 multimer interface [polypeptide binding]; other site 1283331010886 methionine aminotransferase; Validated; Region: PRK09082 1283331010887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283331010888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331010889 homodimer interface [polypeptide binding]; other site 1283331010890 catalytic residue [active] 1283331010891 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283331010892 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283331010893 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331010894 N-terminal plug; other site 1283331010895 ligand-binding site [chemical binding]; other site 1283331010896 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283331010897 FecR protein; Region: FecR; pfam04773 1283331010898 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1283331010899 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331010900 DNA binding residues [nucleotide binding] 1283331010901 GTP-binding protein Der; Reviewed; Region: PRK00093 1283331010902 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1283331010903 G1 box; other site 1283331010904 GTP/Mg2+ binding site [chemical binding]; other site 1283331010905 Switch I region; other site 1283331010906 G2 box; other site 1283331010907 Switch II region; other site 1283331010908 G3 box; other site 1283331010909 G4 box; other site 1283331010910 G5 box; other site 1283331010911 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1283331010912 G1 box; other site 1283331010913 GTP/Mg2+ binding site [chemical binding]; other site 1283331010914 Switch I region; other site 1283331010915 G2 box; other site 1283331010916 G3 box; other site 1283331010917 Switch II region; other site 1283331010918 G4 box; other site 1283331010919 G5 box; other site 1283331010920 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1283331010921 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1283331010922 Trp docking motif [polypeptide binding]; other site 1283331010923 active site 1283331010924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1283331010925 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1283331010926 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1283331010927 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1283331010928 dimer interface [polypeptide binding]; other site 1283331010929 motif 1; other site 1283331010930 active site 1283331010931 motif 2; other site 1283331010932 motif 3; other site 1283331010933 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1283331010934 anticodon binding site; other site 1283331010935 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1283331010936 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1283331010937 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1283331010938 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1283331010939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331010940 non-specific DNA binding site [nucleotide binding]; other site 1283331010941 salt bridge; other site 1283331010942 sequence-specific DNA binding site [nucleotide binding]; other site 1283331010943 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1283331010944 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1283331010945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283331010946 binding surface 1283331010947 TPR motif; other site 1283331010948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283331010949 binding surface 1283331010950 TPR motif; other site 1283331010951 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1283331010952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331010953 FeS/SAM binding site; other site 1283331010954 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1283331010955 active site 1283331010956 multimer interface [polypeptide binding]; other site 1283331010957 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 1283331010958 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1283331010959 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331010960 catalytic loop [active] 1283331010961 iron binding site [ion binding]; other site 1283331010962 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1283331010963 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1283331010964 nucleotide binding site [chemical binding]; other site 1283331010965 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1283331010966 SBD interface [polypeptide binding]; other site 1283331010967 co-chaperone HscB; Provisional; Region: hscB; PRK00294 1283331010968 DnaJ domain; Region: DnaJ; pfam00226 1283331010969 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 1283331010970 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1283331010971 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1283331010972 trimerization site [polypeptide binding]; other site 1283331010973 active site 1283331010974 cysteine desulfurase; Provisional; Region: PRK14012 1283331010975 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1283331010976 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283331010977 catalytic residue [active] 1283331010978 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1283331010979 Rrf2 family protein; Region: rrf2_super; TIGR00738 1283331010980 serine O-acetyltransferase; Region: cysE; TIGR01172 1283331010981 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1283331010982 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1283331010983 trimer interface [polypeptide binding]; other site 1283331010984 active site 1283331010985 substrate binding site [chemical binding]; other site 1283331010986 CoA binding site [chemical binding]; other site 1283331010987 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1283331010988 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1283331010989 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1283331010990 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1283331010991 active site 1283331010992 dimerization interface [polypeptide binding]; other site 1283331010993 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1283331010994 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1283331010995 Protein export membrane protein; Region: SecD_SecF; pfam02355 1283331010996 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1283331010997 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1283331010998 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1283331010999 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1283331011000 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1283331011001 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1283331011002 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1283331011003 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1283331011004 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1283331011005 integrase; Provisional; Region: PRK09692 1283331011006 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1283331011007 active site 1283331011008 Int/Topo IB signature motif; other site 1283331011009 putative transposase OrfB; Reviewed; Region: PHA02517 1283331011010 HTH-like domain; Region: HTH_21; pfam13276 1283331011011 Integrase core domain; Region: rve; pfam00665 1283331011012 Integrase core domain; Region: rve_3; pfam13683 1283331011013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331011014 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331011015 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331011016 Transposase; Region: HTH_Tnp_1; cl17663 1283331011017 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1283331011018 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 1283331011019 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1283331011020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331011021 non-specific DNA binding site [nucleotide binding]; other site 1283331011022 salt bridge; other site 1283331011023 sequence-specific DNA binding site [nucleotide binding]; other site 1283331011024 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1283331011025 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1283331011026 active site 1283331011027 metal binding site [ion binding]; metal-binding site 1283331011028 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1283331011029 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1283331011030 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1283331011031 DNA binding site [nucleotide binding] 1283331011032 active site 1283331011033 CreA protein; Region: CreA; pfam05981 1283331011034 gamma-glutamyl kinase; Provisional; Region: PRK05429 1283331011035 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1283331011036 nucleotide binding site [chemical binding]; other site 1283331011037 homotetrameric interface [polypeptide binding]; other site 1283331011038 putative phosphate binding site [ion binding]; other site 1283331011039 putative allosteric binding site; other site 1283331011040 PUA domain; Region: PUA; pfam01472 1283331011041 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1283331011042 GTP1/OBG; Region: GTP1_OBG; pfam01018 1283331011043 Obg GTPase; Region: Obg; cd01898 1283331011044 G1 box; other site 1283331011045 GTP/Mg2+ binding site [chemical binding]; other site 1283331011046 Switch I region; other site 1283331011047 G2 box; other site 1283331011048 G3 box; other site 1283331011049 Switch II region; other site 1283331011050 G4 box; other site 1283331011051 G5 box; other site 1283331011052 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1283331011053 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1283331011054 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1283331011055 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1283331011056 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1283331011057 substrate binding pocket [chemical binding]; other site 1283331011058 chain length determination region; other site 1283331011059 substrate-Mg2+ binding site; other site 1283331011060 catalytic residues [active] 1283331011061 aspartate-rich region 1; other site 1283331011062 active site lid residues [active] 1283331011063 aspartate-rich region 2; other site 1283331011064 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1283331011065 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1283331011066 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283331011067 hypothetical protein; Provisional; Region: PRK05208 1283331011068 AAA domain; Region: AAA_32; pfam13654 1283331011069 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1283331011070 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1283331011071 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1283331011072 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1283331011073 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283331011074 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331011075 N-terminal plug; other site 1283331011076 ligand-binding site [chemical binding]; other site 1283331011077 fec operon regulator FecR; Reviewed; Region: PRK09774 1283331011078 FecR protein; Region: FecR; pfam04773 1283331011079 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1283331011080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331011081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331011082 DNA binding residues [nucleotide binding] 1283331011083 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1283331011084 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283331011085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283331011086 ABC transporter; Region: ABC_tran_2; pfam12848 1283331011087 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283331011088 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1283331011089 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1283331011090 dimer interface [polypeptide binding]; other site 1283331011091 active site 1283331011092 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1283331011093 folate binding site [chemical binding]; other site 1283331011094 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1283331011095 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1283331011096 P-loop, Walker A motif; other site 1283331011097 Base recognition motif; other site 1283331011098 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1283331011099 Uncharacterized small protein [Function unknown]; Region: COG2879 1283331011100 carbon starvation protein A; Provisional; Region: PRK15015 1283331011101 Carbon starvation protein CstA; Region: CstA; pfam02554 1283331011102 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1283331011103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1283331011104 Cache domain; Region: Cache_2; pfam08269 1283331011105 Histidine kinase; Region: HisKA_3; pfam07730 1283331011106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331011107 ATP binding site [chemical binding]; other site 1283331011108 Mg2+ binding site [ion binding]; other site 1283331011109 G-X-G motif; other site 1283331011110 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1283331011111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331011112 active site 1283331011113 phosphorylation site [posttranslational modification] 1283331011114 intermolecular recognition site; other site 1283331011115 dimerization interface [polypeptide binding]; other site 1283331011116 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283331011117 DNA binding residues [nucleotide binding] 1283331011118 dimerization interface [polypeptide binding]; other site 1283331011119 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1283331011120 DNA repair protein RadA; Provisional; Region: PRK11823 1283331011121 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1283331011122 Walker A motif; other site 1283331011123 ATP binding site [chemical binding]; other site 1283331011124 Walker B motif; other site 1283331011125 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1283331011126 Protein of unknown function (DUF465); Region: DUF465; cl01070 1283331011127 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1283331011128 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1283331011129 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1283331011130 catalytic residues [active] 1283331011131 dimer interface [polypeptide binding]; other site 1283331011132 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1283331011133 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283331011134 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1283331011135 propionate/acetate kinase; Provisional; Region: PRK12379 1283331011136 phosphate acetyltransferase; Reviewed; Region: PRK05632 1283331011137 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1283331011138 DRTGG domain; Region: DRTGG; pfam07085 1283331011139 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1283331011140 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283331011141 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283331011142 ligand binding site [chemical binding]; other site 1283331011143 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1283331011144 Response regulator receiver domain; Region: Response_reg; pfam00072 1283331011145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331011146 active site 1283331011147 phosphorylation site [posttranslational modification] 1283331011148 intermolecular recognition site; other site 1283331011149 dimerization interface [polypeptide binding]; other site 1283331011150 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283331011151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331011152 Staphylococcal nuclease homologues; Region: SNc; smart00318 1283331011153 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1283331011154 Catalytic site; other site 1283331011155 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1283331011156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331011157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331011158 dimer interface [polypeptide binding]; other site 1283331011159 phosphorylation site [posttranslational modification] 1283331011160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331011161 ATP binding site [chemical binding]; other site 1283331011162 Mg2+ binding site [ion binding]; other site 1283331011163 G-X-G motif; other site 1283331011164 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1283331011165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331011166 active site 1283331011167 phosphorylation site [posttranslational modification] 1283331011168 intermolecular recognition site; other site 1283331011169 dimerization interface [polypeptide binding]; other site 1283331011170 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 1283331011171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1283331011172 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1283331011173 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1283331011174 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1283331011175 glycerate dehydrogenase; Provisional; Region: PRK06487 1283331011176 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1283331011177 putative ligand binding site [chemical binding]; other site 1283331011178 putative NAD binding site [chemical binding]; other site 1283331011179 catalytic site [active] 1283331011180 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1283331011181 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1283331011182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331011183 S-adenosylmethionine binding site [chemical binding]; other site 1283331011184 yybP-ykoY; predicted by Infernal 1283331011185 Predicted membrane protein [Function unknown]; Region: COG2119 1283331011186 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1283331011187 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1283331011188 Predicted membrane protein [Function unknown]; Region: COG2119 1283331011189 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1283331011190 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1283331011191 Peptidase family M48; Region: Peptidase_M48; pfam01435 1283331011192 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1283331011193 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1283331011194 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1283331011195 putative acyl-acceptor binding pocket; other site 1283331011196 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1283331011197 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1283331011198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331011199 active site 1283331011200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331011201 active site 1283331011202 ferrochelatase; Reviewed; Region: hemH; PRK00035 1283331011203 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1283331011204 C-terminal domain interface [polypeptide binding]; other site 1283331011205 active site 1283331011206 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1283331011207 active site 1283331011208 N-terminal domain interface [polypeptide binding]; other site 1283331011209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331011210 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1283331011211 NAD(P) binding site [chemical binding]; other site 1283331011212 active site 1283331011213 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1283331011214 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283331011215 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1283331011216 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1283331011217 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1283331011218 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1283331011219 DNA binding residues [nucleotide binding] 1283331011220 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1283331011221 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1283331011222 DNA photolyase; Region: DNA_photolyase; pfam00875 1283331011223 glutamate racemase; Provisional; Region: PRK00865 1283331011224 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1283331011225 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1283331011226 ATP binding site [chemical binding]; other site 1283331011227 substrate interface [chemical binding]; other site 1283331011228 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1283331011229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331011230 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1283331011231 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1283331011232 RF-1 domain; Region: RF-1; pfam00472 1283331011233 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1283331011234 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1283331011235 tRNA; other site 1283331011236 putative tRNA binding site [nucleotide binding]; other site 1283331011237 putative NADP binding site [chemical binding]; other site 1283331011238 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1283331011239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283331011240 TPR motif; other site 1283331011241 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1283331011242 binding surface 1283331011243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283331011244 binding surface 1283331011245 TPR motif; other site 1283331011246 TPR repeat; Region: TPR_11; pfam13414 1283331011247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283331011248 binding surface 1283331011249 TPR motif; other site 1283331011250 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1283331011251 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1283331011252 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1283331011253 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1283331011254 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1283331011255 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331011256 active site 1283331011257 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1283331011258 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1283331011259 5S rRNA interface [nucleotide binding]; other site 1283331011260 CTC domain interface [polypeptide binding]; other site 1283331011261 L16 interface [polypeptide binding]; other site 1283331011262 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1283331011263 putative active site [active] 1283331011264 catalytic residue [active] 1283331011265 GTP-binding protein YchF; Reviewed; Region: PRK09601 1283331011266 YchF GTPase; Region: YchF; cd01900 1283331011267 G1 box; other site 1283331011268 GTP/Mg2+ binding site [chemical binding]; other site 1283331011269 Switch I region; other site 1283331011270 G2 box; other site 1283331011271 Switch II region; other site 1283331011272 G3 box; other site 1283331011273 G4 box; other site 1283331011274 G5 box; other site 1283331011275 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1283331011276 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331011277 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331011278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331011279 dimerization interface [polypeptide binding]; other site 1283331011280 putative DNA binding site [nucleotide binding]; other site 1283331011281 putative Zn2+ binding site [ion binding]; other site 1283331011282 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1283331011283 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1283331011284 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283331011285 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283331011286 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1283331011287 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283331011288 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1283331011289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331011290 FeS/SAM binding site; other site 1283331011291 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1283331011292 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 1283331011293 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1283331011294 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1283331011295 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1283331011296 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1283331011297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331011298 Walker A motif; other site 1283331011299 ATP binding site [chemical binding]; other site 1283331011300 Walker B motif; other site 1283331011301 arginine finger; other site 1283331011302 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331011303 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283331011304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331011305 NAD(P) binding site [chemical binding]; other site 1283331011306 active site 1283331011307 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1283331011308 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1283331011309 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1283331011310 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1283331011311 tetramer interface [polypeptide binding]; other site 1283331011312 TPP-binding site [chemical binding]; other site 1283331011313 heterodimer interface [polypeptide binding]; other site 1283331011314 phosphorylation loop region [posttranslational modification] 1283331011315 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1283331011316 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1283331011317 alpha subunit interface [polypeptide binding]; other site 1283331011318 TPP binding site [chemical binding]; other site 1283331011319 heterodimer interface [polypeptide binding]; other site 1283331011320 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283331011321 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1283331011322 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283331011323 E3 interaction surface; other site 1283331011324 lipoyl attachment site [posttranslational modification]; other site 1283331011325 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283331011326 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1283331011327 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1283331011328 putative NAD(P) binding site [chemical binding]; other site 1283331011329 catalytic Zn binding site [ion binding]; other site 1283331011330 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1283331011331 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1283331011332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331011333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283331011334 putative substrate translocation pore; other site 1283331011335 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1283331011336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1283331011337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1283331011338 FeS/SAM binding site; other site 1283331011339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331011340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331011341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283331011342 dimerization interface [polypeptide binding]; other site 1283331011343 DDE superfamily endonuclease; Region: DDE_5; cl17874 1283331011344 putative transposase OrfB; Reviewed; Region: PHA02517 1283331011345 HTH-like domain; Region: HTH_21; pfam13276 1283331011346 Integrase core domain; Region: rve; pfam00665 1283331011347 Integrase core domain; Region: rve_3; pfam13683 1283331011348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331011349 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331011350 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331011351 Transposase; Region: HTH_Tnp_1; cl17663 1283331011352 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1283331011353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331011354 putative substrate translocation pore; other site 1283331011355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331011356 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283331011357 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331011358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331011359 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1283331011360 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1283331011361 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1283331011362 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1283331011363 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1283331011364 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1283331011365 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1283331011366 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1283331011367 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1283331011368 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1283331011369 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1283331011370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331011371 sequence-specific DNA binding site [nucleotide binding]; other site 1283331011372 salt bridge; other site 1283331011373 Fic family protein [Function unknown]; Region: COG3177 1283331011374 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 1283331011375 Fic/DOC family; Region: Fic; pfam02661 1283331011376 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1283331011377 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331011378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331011379 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1283331011380 putative effector binding pocket; other site 1283331011381 putative dimerization interface [polypeptide binding]; other site 1283331011382 Benzoate membrane transport protein; Region: BenE; pfam03594 1283331011383 benzoate transporter; Region: benE; TIGR00843 1283331011384 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331011385 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1283331011386 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331011387 catalytic loop [active] 1283331011388 iron binding site [ion binding]; other site 1283331011389 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1283331011390 FAD binding pocket [chemical binding]; other site 1283331011391 FAD binding motif [chemical binding]; other site 1283331011392 phosphate binding motif [ion binding]; other site 1283331011393 beta-alpha-beta structure motif; other site 1283331011394 NAD binding pocket [chemical binding]; other site 1283331011395 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1283331011396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331011397 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1283331011398 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1283331011399 active site 1283331011400 catalytic residues [active] 1283331011401 metal binding site [ion binding]; metal-binding site 1283331011402 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1283331011403 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1283331011404 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283331011405 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1283331011406 feruloyl-CoA synthase; Reviewed; Region: PRK08180 1283331011407 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 1283331011408 acyl-activating enzyme (AAE) consensus motif; other site 1283331011409 putative AMP binding site [chemical binding]; other site 1283331011410 putative active site [active] 1283331011411 putative CoA binding site [chemical binding]; other site 1283331011412 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283331011413 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1283331011414 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1283331011415 FMN binding site [chemical binding]; other site 1283331011416 substrate binding site [chemical binding]; other site 1283331011417 putative catalytic residue [active] 1283331011418 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1283331011419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331011420 NAD(P) binding site [chemical binding]; other site 1283331011421 active site 1283331011422 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1283331011423 inter-subunit interface; other site 1283331011424 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1283331011425 iron-sulfur cluster [ion binding]; other site 1283331011426 [2Fe-2S] cluster binding site [ion binding]; other site 1283331011427 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1283331011428 beta subunit interface [polypeptide binding]; other site 1283331011429 alpha subunit interface [polypeptide binding]; other site 1283331011430 active site 1283331011431 substrate binding site [chemical binding]; other site 1283331011432 Fe binding site [ion binding]; other site 1283331011433 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1283331011434 [2Fe-2S] cluster binding site [ion binding]; other site 1283331011435 PhnC is a Class III Extradiol ring-cleavage dioxygenase involved in the polycyclic aromatic hydrocarbon (PAH) catabolic pathway; Region: PhnC_Bs_like; cd07368 1283331011436 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1283331011437 putative active site [active] 1283331011438 Fe(II) binding site [ion binding]; other site 1283331011439 putative dimer interface [polypeptide binding]; other site 1283331011440 putative tetramer interface [polypeptide binding]; other site 1283331011441 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cd07321 1283331011442 dimer interface [polypeptide binding]; other site 1283331011443 tetramer interface [polypeptide binding]; other site 1283331011444 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1283331011445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283331011446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331011447 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331011448 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331011449 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331011450 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331011451 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331011452 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331011453 Transmembrane secretion effector; Region: MFS_3; pfam05977 1283331011454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331011455 putative substrate translocation pore; other site 1283331011456 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1283331011457 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1283331011458 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1283331011459 active site 1283331011460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1283331011461 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1283331011462 Isochorismatase family; Region: Isochorismatase; pfam00857 1283331011463 catalytic triad [active] 1283331011464 dimer interface [polypeptide binding]; other site 1283331011465 conserved cis-peptide bond; other site 1283331011466 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283331011467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331011468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331011469 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1283331011470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1283331011471 Probable transposase; Region: OrfB_IS605; pfam01385 1283331011472 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1283331011473 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1283331011474 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1283331011475 active site 1283331011476 homotetramer interface [polypeptide binding]; other site 1283331011477 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1283331011478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331011479 active site 1283331011480 motif I; other site 1283331011481 motif II; other site 1283331011482 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1283331011483 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1283331011484 2-isopropylmalate synthase; Validated; Region: PRK00915 1283331011485 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1283331011486 active site 1283331011487 catalytic residues [active] 1283331011488 metal binding site [ion binding]; metal-binding site 1283331011489 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1283331011490 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1283331011491 mce related protein; Region: MCE; pfam02470 1283331011492 mce related protein; Region: MCE; pfam02470 1283331011493 mce related protein; Region: MCE; pfam02470 1283331011494 mce related protein; Region: MCE; pfam02470 1283331011495 mce related protein; Region: MCE; pfam02470 1283331011496 mce related protein; Region: MCE; pfam02470 1283331011497 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1283331011498 Paraquat-inducible protein A; Region: PqiA; pfam04403 1283331011499 Paraquat-inducible protein A; Region: PqiA; pfam04403 1283331011500 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1283331011501 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1283331011502 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1283331011503 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1283331011504 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1283331011505 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1283331011506 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1283331011507 putative valine binding site [chemical binding]; other site 1283331011508 dimer interface [polypeptide binding]; other site 1283331011509 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1283331011510 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1283331011511 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1283331011512 PYR/PP interface [polypeptide binding]; other site 1283331011513 dimer interface [polypeptide binding]; other site 1283331011514 TPP binding site [chemical binding]; other site 1283331011515 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1283331011516 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1283331011517 TPP-binding site [chemical binding]; other site 1283331011518 dimer interface [polypeptide binding]; other site 1283331011519 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1283331011520 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1283331011521 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1283331011522 Transglycosylase; Region: Transgly; pfam00912 1283331011523 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1283331011524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1283331011525 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1283331011526 AAA domain; Region: AAA_33; pfam13671 1283331011527 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1283331011528 active site 1283331011529 Protein of unknown function, DUF399; Region: DUF399; cl01139 1283331011530 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1283331011531 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1283331011532 Walker A/P-loop; other site 1283331011533 ATP binding site [chemical binding]; other site 1283331011534 Q-loop/lid; other site 1283331011535 ABC transporter signature motif; other site 1283331011536 Walker B; other site 1283331011537 D-loop; other site 1283331011538 H-loop/switch region; other site 1283331011539 FecCD transport family; Region: FecCD; pfam01032 1283331011540 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1283331011541 iron-sulfur cluster [ion binding]; other site 1283331011542 [2Fe-2S] cluster binding site [ion binding]; other site 1283331011543 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1283331011544 hypothetical protein; Provisional; Region: PRK08960 1283331011545 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283331011546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331011547 homodimer interface [polypeptide binding]; other site 1283331011548 catalytic residue [active] 1283331011549 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1283331011550 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1283331011551 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1283331011552 active site 1283331011553 HIGH motif; other site 1283331011554 nucleotide binding site [chemical binding]; other site 1283331011555 active site 1283331011556 KMSKS motif; other site 1283331011557 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1283331011558 Na binding site [ion binding]; other site 1283331011559 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1283331011560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331011561 putative active site [active] 1283331011562 heme pocket [chemical binding]; other site 1283331011563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331011564 dimer interface [polypeptide binding]; other site 1283331011565 phosphorylation site [posttranslational modification] 1283331011566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331011567 ATP binding site [chemical binding]; other site 1283331011568 Mg2+ binding site [ion binding]; other site 1283331011569 G-X-G motif; other site 1283331011570 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283331011571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331011572 active site 1283331011573 phosphorylation site [posttranslational modification] 1283331011574 intermolecular recognition site; other site 1283331011575 dimerization interface [polypeptide binding]; other site 1283331011576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331011577 Walker A motif; other site 1283331011578 ATP binding site [chemical binding]; other site 1283331011579 Walker B motif; other site 1283331011580 arginine finger; other site 1283331011581 poly(A) polymerase; Region: pcnB; TIGR01942 1283331011582 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1283331011583 active site 1283331011584 NTP binding site [chemical binding]; other site 1283331011585 metal binding triad [ion binding]; metal-binding site 1283331011586 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1283331011587 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1283331011588 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1283331011589 catalytic center binding site [active] 1283331011590 ATP binding site [chemical binding]; other site 1283331011591 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1283331011592 oligomerization interface [polypeptide binding]; other site 1283331011593 active site 1283331011594 metal binding site [ion binding]; metal-binding site 1283331011595 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1283331011596 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1283331011597 active site 1283331011598 ATP-binding site [chemical binding]; other site 1283331011599 pantoate-binding site; other site 1283331011600 HXXH motif; other site 1283331011601 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1283331011602 tetramerization interface [polypeptide binding]; other site 1283331011603 active site 1283331011604 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1283331011605 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1283331011606 active site 1283331011607 dimer interface [polypeptide binding]; other site 1283331011608 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1283331011609 dimer interface [polypeptide binding]; other site 1283331011610 active site 1283331011611 acetyl-CoA synthetase; Provisional; Region: PRK00174 1283331011612 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1283331011613 active site 1283331011614 CoA binding site [chemical binding]; other site 1283331011615 acyl-activating enzyme (AAE) consensus motif; other site 1283331011616 AMP binding site [chemical binding]; other site 1283331011617 acetate binding site [chemical binding]; other site 1283331011618 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1283331011619 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1283331011620 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1283331011621 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1283331011622 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1283331011623 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1283331011624 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1283331011625 RNase E interface [polypeptide binding]; other site 1283331011626 trimer interface [polypeptide binding]; other site 1283331011627 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1283331011628 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1283331011629 RNase E interface [polypeptide binding]; other site 1283331011630 trimer interface [polypeptide binding]; other site 1283331011631 active site 1283331011632 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1283331011633 putative nucleic acid binding region [nucleotide binding]; other site 1283331011634 G-X-X-G motif; other site 1283331011635 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1283331011636 RNA binding site [nucleotide binding]; other site 1283331011637 domain interface; other site 1283331011638 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1283331011639 16S/18S rRNA binding site [nucleotide binding]; other site 1283331011640 S13e-L30e interaction site [polypeptide binding]; other site 1283331011641 25S rRNA binding site [nucleotide binding]; other site 1283331011642 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1283331011643 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1283331011644 RNA binding site [nucleotide binding]; other site 1283331011645 active site 1283331011646 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1283331011647 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1283331011648 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1283331011649 translation initiation factor IF-2; Region: IF-2; TIGR00487 1283331011650 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1283331011651 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1283331011652 G1 box; other site 1283331011653 putative GEF interaction site [polypeptide binding]; other site 1283331011654 GTP/Mg2+ binding site [chemical binding]; other site 1283331011655 Switch I region; other site 1283331011656 G2 box; other site 1283331011657 G3 box; other site 1283331011658 Switch II region; other site 1283331011659 G4 box; other site 1283331011660 G5 box; other site 1283331011661 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1283331011662 Translation-initiation factor 2; Region: IF-2; pfam11987 1283331011663 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1283331011664 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1283331011665 NusA N-terminal domain; Region: NusA_N; pfam08529 1283331011666 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1283331011667 RNA binding site [nucleotide binding]; other site 1283331011668 homodimer interface [polypeptide binding]; other site 1283331011669 NusA-like KH domain; Region: KH_5; pfam13184 1283331011670 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1283331011671 G-X-X-G motif; other site 1283331011672 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1283331011673 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1283331011674 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1283331011675 Sm and related proteins; Region: Sm_like; cl00259 1283331011676 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1283331011677 putative oligomer interface [polypeptide binding]; other site 1283331011678 putative RNA binding site [nucleotide binding]; other site 1283331011679 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1283331011680 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1283331011681 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1283331011682 active site 1283331011683 substrate binding site [chemical binding]; other site 1283331011684 metal binding site [ion binding]; metal-binding site 1283331011685 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1283331011686 dihydropteroate synthase; Region: DHPS; TIGR01496 1283331011687 substrate binding pocket [chemical binding]; other site 1283331011688 dimer interface [polypeptide binding]; other site 1283331011689 inhibitor binding site; inhibition site 1283331011690 FtsH Extracellular; Region: FtsH_ext; pfam06480 1283331011691 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1283331011692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331011693 Walker A motif; other site 1283331011694 ATP binding site [chemical binding]; other site 1283331011695 Walker B motif; other site 1283331011696 arginine finger; other site 1283331011697 Peptidase family M41; Region: Peptidase_M41; pfam01434 1283331011698 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1283331011699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331011700 S-adenosylmethionine binding site [chemical binding]; other site 1283331011701 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1283331011702 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1283331011703 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1283331011704 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1283331011705 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1283331011706 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1283331011707 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1283331011708 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1283331011709 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1283331011710 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1283331011711 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1283331011712 IMP binding site; other site 1283331011713 dimer interface [polypeptide binding]; other site 1283331011714 interdomain contacts; other site 1283331011715 partial ornithine binding site; other site 1283331011716 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1283331011717 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1283331011718 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1283331011719 catalytic site [active] 1283331011720 subunit interface [polypeptide binding]; other site 1283331011721 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1283331011722 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1283331011723 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1283331011724 chaperone protein DnaJ; Provisional; Region: PRK10767 1283331011725 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1283331011726 HSP70 interaction site [polypeptide binding]; other site 1283331011727 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1283331011728 substrate binding site [polypeptide binding]; other site 1283331011729 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1283331011730 Zn binding sites [ion binding]; other site 1283331011731 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1283331011732 dimer interface [polypeptide binding]; other site 1283331011733 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1283331011734 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1283331011735 nucleotide binding site [chemical binding]; other site 1283331011736 NEF interaction site [polypeptide binding]; other site 1283331011737 SBD interface [polypeptide binding]; other site 1283331011738 GrpE; Region: GrpE; pfam01025 1283331011739 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1283331011740 dimer interface [polypeptide binding]; other site 1283331011741 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1283331011742 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1283331011743 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1283331011744 Walker A/P-loop; other site 1283331011745 ATP binding site [chemical binding]; other site 1283331011746 Q-loop/lid; other site 1283331011747 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1283331011748 ABC transporter signature motif; other site 1283331011749 Walker B; other site 1283331011750 D-loop; other site 1283331011751 H-loop/switch region; other site 1283331011752 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1283331011753 metal binding site 2 [ion binding]; metal-binding site 1283331011754 putative DNA binding helix; other site 1283331011755 metal binding site 1 [ion binding]; metal-binding site 1283331011756 dimer interface [polypeptide binding]; other site 1283331011757 structural Zn2+ binding site [ion binding]; other site 1283331011758 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1283331011759 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1283331011760 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1283331011761 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 1283331011762 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1283331011763 putative coenzyme Q binding site [chemical binding]; other site 1283331011764 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1283331011765 SmpB-tmRNA interface; other site 1283331011766 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1283331011767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283331011768 DNA-binding site [nucleotide binding]; DNA binding site 1283331011769 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1283331011770 L-lactate permease; Region: Lactate_perm; cl00701 1283331011771 glycolate transporter; Provisional; Region: PRK09695 1283331011772 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1283331011773 Cysteine-rich domain; Region: CCG; pfam02754 1283331011774 Cysteine-rich domain; Region: CCG; pfam02754 1283331011775 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1283331011776 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1283331011777 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283331011778 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1283331011779 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1283331011780 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1283331011781 FAD binding domain; Region: FAD_binding_4; pfam01565 1283331011782 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283331011783 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1283331011784 Cysteine-rich domain; Region: CCG; pfam02754 1283331011785 Cache domain; Region: Cache_1; pfam02743 1283331011786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331011787 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1283331011788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331011789 dimer interface [polypeptide binding]; other site 1283331011790 phosphorylation site [posttranslational modification] 1283331011791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331011792 ATP binding site [chemical binding]; other site 1283331011793 Mg2+ binding site [ion binding]; other site 1283331011794 G-X-G motif; other site 1283331011795 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 1283331011796 Int/Topo IB signature motif; other site 1283331011797 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1283331011798 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1283331011799 catalytic residues [active] 1283331011800 catalytic nucleophile [active] 1283331011801 Presynaptic Site I dimer interface [polypeptide binding]; other site 1283331011802 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1283331011803 Synaptic Flat tetramer interface [polypeptide binding]; other site 1283331011804 Synaptic Site I dimer interface [polypeptide binding]; other site 1283331011805 DNA binding site [nucleotide binding] 1283331011806 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255 1283331011807 putative nucleotide binding site [chemical binding]; other site 1283331011808 putative substrate binding site [chemical binding]; other site 1283331011809 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255 1283331011810 putative nucleotide binding site [chemical binding]; other site 1283331011811 putative substrate binding site [chemical binding]; other site 1283331011812 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1283331011813 PYR/PP interface [polypeptide binding]; other site 1283331011814 dimer interface [polypeptide binding]; other site 1283331011815 TPP binding site [chemical binding]; other site 1283331011816 transcriptional activator TtdR; Provisional; Region: PRK09801 1283331011817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331011818 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331011819 putative effector binding pocket; other site 1283331011820 dimerization interface [polypeptide binding]; other site 1283331011821 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1283331011822 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1283331011823 putative NAD(P) binding site [chemical binding]; other site 1283331011824 glycolate transporter; Provisional; Region: PRK09695 1283331011825 L-lactate permease; Region: Lactate_perm; cl00701 1283331011826 malate synthase G; Provisional; Region: PRK02999 1283331011827 active site 1283331011828 Domain of unknown function (DUF336); Region: DUF336; cl01249 1283331011829 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1283331011830 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283331011831 Cysteine-rich domain; Region: CCG; pfam02754 1283331011832 Cysteine-rich domain; Region: CCG; pfam02754 1283331011833 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1283331011834 FAD binding domain; Region: FAD_binding_4; pfam01565 1283331011835 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1283331011836 FAD binding domain; Region: FAD_binding_4; pfam01565 1283331011837 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1283331011838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283331011839 DNA-binding site [nucleotide binding]; DNA binding site 1283331011840 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1283331011841 enolase; Provisional; Region: eno; PRK00077 1283331011842 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283331011843 dimer interface [polypeptide binding]; other site 1283331011844 metal binding site [ion binding]; metal-binding site 1283331011845 substrate binding pocket [chemical binding]; other site 1283331011846 pyruvate kinase; Provisional; Region: PRK05826 1283331011847 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283331011848 domain interfaces; other site 1283331011849 active site 1283331011850 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1283331011851 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1283331011852 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1283331011853 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1283331011854 glyoxylate carboligase; Provisional; Region: PRK11269 1283331011855 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1283331011856 TPP binding site [chemical binding]; other site 1283331011857 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1283331011858 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1283331011859 TPP-binding site [chemical binding]; other site 1283331011860 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1283331011861 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1283331011862 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1283331011863 Pirin-related protein [General function prediction only]; Region: COG1741 1283331011864 Pirin; Region: Pirin; pfam02678 1283331011865 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1283331011866 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1283331011867 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1283331011868 CAP-like domain; other site 1283331011869 active site 1283331011870 primary dimer interface [polypeptide binding]; other site 1283331011871 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1283331011872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331011873 ATP binding site [chemical binding]; other site 1283331011874 Mg2+ binding site [ion binding]; other site 1283331011875 G-X-G motif; other site 1283331011876 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1283331011877 anchoring element; other site 1283331011878 dimer interface [polypeptide binding]; other site 1283331011879 ATP binding site [chemical binding]; other site 1283331011880 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1283331011881 active site 1283331011882 metal binding site [ion binding]; metal-binding site 1283331011883 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1283331011884 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1283331011885 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283331011886 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1283331011887 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1283331011888 active site 1283331011889 metal binding site [ion binding]; metal-binding site 1283331011890 hexamer interface [polypeptide binding]; other site 1283331011891 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1283331011892 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1283331011893 putative ligand binding site [chemical binding]; other site 1283331011894 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1283331011895 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1283331011896 TM-ABC transporter signature motif; other site 1283331011897 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1283331011898 TM-ABC transporter signature motif; other site 1283331011899 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1283331011900 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1283331011901 Walker A/P-loop; other site 1283331011902 ATP binding site [chemical binding]; other site 1283331011903 Q-loop/lid; other site 1283331011904 ABC transporter signature motif; other site 1283331011905 Walker B; other site 1283331011906 D-loop; other site 1283331011907 H-loop/switch region; other site 1283331011908 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283331011909 acyl-activating enzyme (AAE) consensus motif; other site 1283331011910 CoA binding site [chemical binding]; other site 1283331011911 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1283331011912 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283331011913 active site 1283331011914 dimer interface [polypeptide binding]; other site 1283331011915 non-prolyl cis peptide bond; other site 1283331011916 insertion regions; other site 1283331011917 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1283331011918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331011919 non-specific DNA binding site [nucleotide binding]; other site 1283331011920 salt bridge; other site 1283331011921 sequence-specific DNA binding site [nucleotide binding]; other site 1283331011922 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1283331011923 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283331011924 TM-ABC transporter signature motif; other site 1283331011925 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1283331011926 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283331011927 TM-ABC transporter signature motif; other site 1283331011928 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1283331011929 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1283331011930 Walker A/P-loop; other site 1283331011931 ATP binding site [chemical binding]; other site 1283331011932 Q-loop/lid; other site 1283331011933 ABC transporter signature motif; other site 1283331011934 Walker B; other site 1283331011935 D-loop; other site 1283331011936 H-loop/switch region; other site 1283331011937 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1283331011938 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1283331011939 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283331011940 putative ligand binding site [chemical binding]; other site 1283331011941 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1283331011942 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283331011943 putative ligand binding site [chemical binding]; other site 1283331011944 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283331011945 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1283331011946 Flavin binding site [chemical binding]; other site 1283331011947 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283331011948 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1283331011949 Flavin binding site [chemical binding]; other site 1283331011950 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1283331011951 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1283331011952 putative ligand binding site [chemical binding]; other site 1283331011953 NAD binding site [chemical binding]; other site 1283331011954 catalytic site [active] 1283331011955 BON domain; Region: BON; pfam04972 1283331011956 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1283331011957 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1283331011958 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1283331011959 dimerization interface [polypeptide binding]; other site 1283331011960 active site 1283331011961 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1283331011962 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1283331011963 Walker A/P-loop; other site 1283331011964 ATP binding site [chemical binding]; other site 1283331011965 Q-loop/lid; other site 1283331011966 ABC transporter signature motif; other site 1283331011967 Walker B; other site 1283331011968 D-loop; other site 1283331011969 H-loop/switch region; other site 1283331011970 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1283331011971 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1283331011972 putative ligand binding site [chemical binding]; other site 1283331011973 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1283331011974 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1283331011975 putative ligand binding site [chemical binding]; other site 1283331011976 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331011977 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1283331011978 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1283331011979 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1283331011980 putative ligand binding site [chemical binding]; other site 1283331011981 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1283331011982 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1283331011983 TM-ABC transporter signature motif; other site 1283331011984 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1283331011985 TM-ABC transporter signature motif; other site 1283331011986 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1283331011987 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1283331011988 Walker A/P-loop; other site 1283331011989 ATP binding site [chemical binding]; other site 1283331011990 Q-loop/lid; other site 1283331011991 ABC transporter signature motif; other site 1283331011992 Walker B; other site 1283331011993 D-loop; other site 1283331011994 H-loop/switch region; other site 1283331011995 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283331011996 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331011997 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283331011998 active site 1283331011999 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331012000 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283331012001 active site 1283331012002 non-prolyl cis peptide bond; other site 1283331012003 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331012004 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1283331012005 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1283331012006 homodimer interface [polypeptide binding]; other site 1283331012007 substrate-cofactor binding pocket; other site 1283331012008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331012009 catalytic residue [active] 1283331012010 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1283331012011 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1283331012012 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283331012013 active site 1283331012014 dimer interface [polypeptide binding]; other site 1283331012015 non-prolyl cis peptide bond; other site 1283331012016 insertion regions; other site 1283331012017 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283331012018 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1283331012019 Flavin binding site [chemical binding]; other site 1283331012020 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1283331012021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331012022 Walker A motif; other site 1283331012023 ATP binding site [chemical binding]; other site 1283331012024 Walker B motif; other site 1283331012025 arginine finger; other site 1283331012026 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1283331012027 Chromate transporter; Region: Chromate_transp; pfam02417 1283331012028 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283331012029 IHF dimer interface [polypeptide binding]; other site 1283331012030 IHF - DNA interface [nucleotide binding]; other site 1283331012031 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283331012032 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331012033 active site 1283331012034 non-prolyl cis peptide bond; other site 1283331012035 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283331012036 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331012037 N-terminal plug; other site 1283331012038 ligand-binding site [chemical binding]; other site 1283331012039 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283331012040 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283331012041 active site 1283331012042 non-prolyl cis peptide bond; other site 1283331012043 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1283331012044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331012045 membrane-bound complex binding site; other site 1283331012046 hinge residues; other site 1283331012047 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1283331012048 intersubunit interface [polypeptide binding]; other site 1283331012049 active site 1283331012050 Zn2+ binding site [ion binding]; other site 1283331012051 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331012052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331012053 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1283331012054 putative dimerization interface [polypeptide binding]; other site 1283331012055 transmembrane helices; other site 1283331012056 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1283331012057 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1283331012058 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 1283331012059 phosphate acetyltransferase; Provisional; Region: PRK11890 1283331012060 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 1283331012061 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1283331012062 propionate/acetate kinase; Provisional; Region: PRK12379 1283331012063 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 1283331012064 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1283331012065 NAD binding site [chemical binding]; other site 1283331012066 homotetramer interface [polypeptide binding]; other site 1283331012067 homodimer interface [polypeptide binding]; other site 1283331012068 substrate binding site [chemical binding]; other site 1283331012069 active site 1283331012070 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1283331012071 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283331012072 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331012073 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1283331012074 Paraquat-inducible protein A; Region: PqiA; pfam04403 1283331012075 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1283331012076 Paraquat-inducible protein A; Region: PqiA; pfam04403 1283331012077 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1283331012078 mce related protein; Region: MCE; pfam02470 1283331012079 mce related protein; Region: MCE; pfam02470 1283331012080 mce related protein; Region: MCE; pfam02470 1283331012081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1283331012082 Transposase; Region: HTH_Tnp_1; pfam01527 1283331012083 Integrase core domain; Region: rve; pfam00665 1283331012084 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283331012085 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283331012086 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331012087 N-terminal plug; other site 1283331012088 ligand-binding site [chemical binding]; other site 1283331012089 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283331012090 FecR protein; Region: FecR; pfam04773 1283331012091 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1283331012092 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331012093 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331012094 DNA binding residues [nucleotide binding] 1283331012095 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1283331012096 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1283331012097 Ion channel; Region: Ion_trans_2; pfam07885 1283331012098 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1283331012099 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1283331012100 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283331012101 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331012102 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1283331012103 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1283331012104 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283331012105 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283331012106 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1283331012107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331012108 Walker A/P-loop; other site 1283331012109 ATP binding site [chemical binding]; other site 1283331012110 Q-loop/lid; other site 1283331012111 ABC transporter signature motif; other site 1283331012112 Walker B; other site 1283331012113 D-loop; other site 1283331012114 H-loop/switch region; other site 1283331012115 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1283331012116 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1283331012117 substrate-cofactor binding pocket; other site 1283331012118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331012119 catalytic residue [active] 1283331012120 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283331012121 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1283331012122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331012123 NAD(P) binding site [chemical binding]; other site 1283331012124 active site 1283331012125 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 1283331012126 active site 1283331012127 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1283331012128 active site 1283331012129 metal-binding site 1283331012130 Predicted permeases [General function prediction only]; Region: COG0795 1283331012131 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1283331012132 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1283331012133 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1283331012134 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1283331012135 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1283331012136 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1283331012137 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1283331012138 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1283331012139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1283331012140 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 1283331012141 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1283331012142 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1283331012143 active site 1283331012144 metal binding site [ion binding]; metal-binding site 1283331012145 Phosphotransferase enzyme family; Region: APH; pfam01636 1283331012146 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1283331012147 active site 1283331012148 ATP binding site [chemical binding]; other site 1283331012149 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283331012150 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1283331012151 active site 1283331012152 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1283331012153 CHASE domain; Region: CHASE; pfam03924 1283331012154 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331012155 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331012156 metal binding site [ion binding]; metal-binding site 1283331012157 active site 1283331012158 I-site; other site 1283331012159 Predicted permeases [General function prediction only]; Region: COG0679 1283331012160 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1283331012161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331012162 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283331012163 dimerization interface [polypeptide binding]; other site 1283331012164 substrate binding pocket [chemical binding]; other site 1283331012165 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331012166 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283331012167 active site 1283331012168 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283331012169 substrate binding pocket [chemical binding]; other site 1283331012170 membrane-bound complex binding site; other site 1283331012171 hinge residues; other site 1283331012172 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283331012173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331012174 dimer interface [polypeptide binding]; other site 1283331012175 conserved gate region; other site 1283331012176 putative PBP binding loops; other site 1283331012177 ABC-ATPase subunit interface; other site 1283331012178 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283331012179 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283331012180 Walker A/P-loop; other site 1283331012181 ATP binding site [chemical binding]; other site 1283331012182 Q-loop/lid; other site 1283331012183 ABC transporter signature motif; other site 1283331012184 Walker B; other site 1283331012185 D-loop; other site 1283331012186 H-loop/switch region; other site 1283331012187 NMT1/THI5 like; Region: NMT1; pfam09084 1283331012188 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283331012189 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 1283331012190 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1283331012191 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1283331012192 dimer interface [polypeptide binding]; other site 1283331012193 ADP-ribose binding site [chemical binding]; other site 1283331012194 active site 1283331012195 nudix motif; other site 1283331012196 metal binding site [ion binding]; metal-binding site 1283331012197 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1283331012198 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1283331012199 ThiC-associated domain; Region: ThiC-associated; pfam13667 1283331012200 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1283331012201 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1283331012202 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1283331012203 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283331012204 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1283331012205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1283331012206 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331012207 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331012208 active site 1283331012209 catalytic tetrad [active] 1283331012210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331012211 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331012212 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331012213 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331012214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331012215 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1283331012216 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1283331012217 putative ribose interaction site [chemical binding]; other site 1283331012218 putative ADP binding site [chemical binding]; other site 1283331012219 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1283331012220 active site 1283331012221 nucleotide binding site [chemical binding]; other site 1283331012222 HIGH motif; other site 1283331012223 KMSKS motif; other site 1283331012224 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1283331012225 Mig-14; Region: Mig-14; pfam07395 1283331012226 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1283331012227 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1283331012228 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283331012229 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1283331012230 Walker A/P-loop; other site 1283331012231 ATP binding site [chemical binding]; other site 1283331012232 Q-loop/lid; other site 1283331012233 ABC transporter signature motif; other site 1283331012234 Walker B; other site 1283331012235 D-loop; other site 1283331012236 H-loop/switch region; other site 1283331012237 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1283331012238 active site 1283331012239 ATP binding site [chemical binding]; other site 1283331012240 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1283331012241 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1283331012242 NAD binding site [chemical binding]; other site 1283331012243 homodimer interface [polypeptide binding]; other site 1283331012244 active site 1283331012245 substrate binding site [chemical binding]; other site 1283331012246 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1283331012247 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1283331012248 Ligand binding site; other site 1283331012249 metal-binding site 1283331012250 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1283331012251 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1283331012252 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1283331012253 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1283331012254 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283331012255 putative ADP-binding pocket [chemical binding]; other site 1283331012256 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1283331012257 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1283331012258 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1283331012259 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1283331012260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283331012261 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1283331012262 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1283331012263 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1283331012264 putative active site [active] 1283331012265 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1283331012266 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1283331012267 putative active site [active] 1283331012268 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1283331012269 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1283331012270 homodimer interface [polypeptide binding]; other site 1283331012271 substrate-cofactor binding pocket; other site 1283331012272 catalytic residue [active] 1283331012273 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1283331012274 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1283331012275 metal binding triad; other site 1283331012276 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1283331012277 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1283331012278 metal binding triad; other site 1283331012279 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1283331012280 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1283331012281 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1283331012282 dimer interface [polypeptide binding]; other site 1283331012283 TPP-binding site [chemical binding]; other site 1283331012284 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1283331012285 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1283331012286 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283331012287 E3 interaction surface; other site 1283331012288 lipoyl attachment site [posttranslational modification]; other site 1283331012289 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283331012290 E3 interaction surface; other site 1283331012291 lipoyl attachment site [posttranslational modification]; other site 1283331012292 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283331012293 E3 interaction surface; other site 1283331012294 lipoyl attachment site [posttranslational modification]; other site 1283331012295 e3 binding domain; Region: E3_binding; pfam02817 1283331012296 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1283331012297 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1283331012298 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1283331012299 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283331012300 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1283331012301 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1283331012302 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1283331012303 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331012304 Ligand Binding Site [chemical binding]; other site 1283331012305 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331012306 Ligand Binding Site [chemical binding]; other site 1283331012307 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1283331012308 AAA domain; Region: AAA_33; pfam13671 1283331012309 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1283331012310 active site 1283331012311 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283331012312 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283331012313 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331012314 N-terminal plug; other site 1283331012315 ligand-binding site [chemical binding]; other site 1283331012316 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1283331012317 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1283331012318 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283331012319 FecR protein; Region: FecR; pfam04773 1283331012320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331012321 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1283331012322 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331012323 DNA binding residues [nucleotide binding] 1283331012324 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1283331012325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331012326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331012327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331012328 dimerization interface [polypeptide binding]; other site 1283331012329 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1283331012330 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1283331012331 active site 1 [active] 1283331012332 dimer interface [polypeptide binding]; other site 1283331012333 hexamer interface [polypeptide binding]; other site 1283331012334 active site 2 [active] 1283331012335 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1283331012336 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1283331012337 TrkA-C domain; Region: TrkA_C; pfam02080 1283331012338 Transporter associated domain; Region: CorC_HlyC; smart01091 1283331012339 hypothetical protein; Provisional; Region: PRK11281 1283331012340 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1283331012341 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1283331012342 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1283331012343 hypothetical protein; Validated; Region: PRK00029 1283331012344 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1283331012345 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283331012346 thioredoxin 2; Provisional; Region: PRK10996 1283331012347 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1283331012348 catalytic residues [active] 1283331012349 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331012350 Ligand Binding Site [chemical binding]; other site 1283331012351 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331012352 Ligand Binding Site [chemical binding]; other site 1283331012353 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1283331012354 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283331012355 P-loop; other site 1283331012356 Magnesium ion binding site [ion binding]; other site 1283331012357 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283331012358 Magnesium ion binding site [ion binding]; other site 1283331012359 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1283331012360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331012361 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283331012362 dimerization interface [polypeptide binding]; other site 1283331012363 substrate binding pocket [chemical binding]; other site 1283331012364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283331012365 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1283331012366 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1283331012367 substrate binding site [chemical binding]; other site 1283331012368 active site 1283331012369 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1283331012370 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283331012371 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1283331012372 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1283331012373 active site 1283331012374 dimer interface [polypeptide binding]; other site 1283331012375 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1283331012376 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1283331012377 active site 1283331012378 FMN binding site [chemical binding]; other site 1283331012379 substrate binding site [chemical binding]; other site 1283331012380 3Fe-4S cluster binding site [ion binding]; other site 1283331012381 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1283331012382 domain interface; other site 1283331012383 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1283331012384 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1283331012385 Sporulation related domain; Region: SPOR; pfam05036 1283331012386 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1283331012387 active site 1283331012388 dimer interface [polypeptide binding]; other site 1283331012389 metal binding site [ion binding]; metal-binding site 1283331012390 shikimate kinase; Reviewed; Region: aroK; PRK00131 1283331012391 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1283331012392 ADP binding site [chemical binding]; other site 1283331012393 magnesium binding site [ion binding]; other site 1283331012394 putative shikimate binding site; other site 1283331012395 AMIN domain; Region: AMIN; pfam11741 1283331012396 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1283331012397 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283331012398 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1283331012399 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1283331012400 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 1283331012401 Pilus assembly protein, PilP; Region: PilP; pfam04351 1283331012402 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 1283331012403 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1283331012404 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1283331012405 Competence protein A; Region: Competence_A; pfam11104 1283331012406 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1283331012407 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1283331012408 Transglycosylase; Region: Transgly; pfam00912 1283331012409 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1283331012410 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1283331012411 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1283331012412 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1283331012413 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1283331012414 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1283331012415 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1283331012416 putative NAD(P) binding site [chemical binding]; other site 1283331012417 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1283331012418 primosome assembly protein PriA; Validated; Region: PRK05580 1283331012419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283331012420 ATP binding site [chemical binding]; other site 1283331012421 putative Mg++ binding site [ion binding]; other site 1283331012422 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1283331012423 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 1283331012424 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1283331012425 ATP-binding site [chemical binding]; other site 1283331012426 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1283331012427 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1283331012428 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1283331012429 active site 1283331012430 HIGH motif; other site 1283331012431 KMSK motif region; other site 1283331012432 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1283331012433 tRNA binding surface [nucleotide binding]; other site 1283331012434 anticodon binding site; other site 1283331012435 Sporulation related domain; Region: SPOR; pfam05036 1283331012436 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1283331012437 active site 1283331012438 HslU subunit interaction site [polypeptide binding]; other site 1283331012439 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1283331012440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331012441 Walker A motif; other site 1283331012442 ATP binding site [chemical binding]; other site 1283331012443 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1283331012444 Walker B motif; other site 1283331012445 arginine finger; other site 1283331012446 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1283331012447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1283331012448 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1283331012449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331012450 S-adenosylmethionine binding site [chemical binding]; other site 1283331012451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1283331012452 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1283331012453 ABC1 family; Region: ABC1; cl17513 1283331012454 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1283331012455 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1283331012456 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1283331012457 metal binding site [ion binding]; metal-binding site 1283331012458 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 1283331012459 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1283331012460 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1283331012461 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1283331012462 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1283331012463 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283331012464 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1283331012465 Ligand binding site; other site 1283331012466 DXD motif; other site 1283331012467 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1283331012468 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1283331012469 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283331012470 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1283331012471 Ligand binding site; other site 1283331012472 DXD motif; other site 1283331012473 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1283331012474 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1283331012475 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 1283331012476 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1283331012477 putative active site [active] 1283331012478 dimerization interface [polypeptide binding]; other site 1283331012479 putative tRNAtyr binding site [nucleotide binding]; other site 1283331012480 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1283331012481 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283331012482 TAP-like protein; Region: Abhydrolase_4; pfam08386 1283331012483 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1283331012484 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1283331012485 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1283331012486 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1283331012487 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1283331012488 active site 1283331012489 Cupin domain; Region: Cupin_2; cl17218 1283331012490 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1283331012491 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1283331012492 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1283331012493 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1283331012494 AMP binding site [chemical binding]; other site 1283331012495 metal binding site [ion binding]; metal-binding site 1283331012496 active site 1283331012497 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1283331012498 homodimer interface [polypeptide binding]; other site 1283331012499 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1283331012500 active site pocket [active] 1283331012501 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1283331012502 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1283331012503 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1283331012504 amphipathic channel; other site 1283331012505 Asn-Pro-Ala signature motifs; other site 1283331012506 glycerol kinase; Provisional; Region: glpK; PRK00047 1283331012507 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1283331012508 N- and C-terminal domain interface [polypeptide binding]; other site 1283331012509 active site 1283331012510 MgATP binding site [chemical binding]; other site 1283331012511 catalytic site [active] 1283331012512 metal binding site [ion binding]; metal-binding site 1283331012513 glycerol binding site [chemical binding]; other site 1283331012514 homotetramer interface [polypeptide binding]; other site 1283331012515 homodimer interface [polypeptide binding]; other site 1283331012516 FBP binding site [chemical binding]; other site 1283331012517 protein IIAGlc interface [polypeptide binding]; other site 1283331012518 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1283331012519 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1283331012520 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1283331012521 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1283331012522 enolase; Provisional; Region: eno; PRK00077 1283331012523 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283331012524 dimer interface [polypeptide binding]; other site 1283331012525 metal binding site [ion binding]; metal-binding site 1283331012526 substrate binding pocket [chemical binding]; other site 1283331012527 triosephosphate isomerase; Provisional; Region: PRK14567 1283331012528 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1283331012529 substrate binding site [chemical binding]; other site 1283331012530 dimer interface [polypeptide binding]; other site 1283331012531 catalytic triad [active] 1283331012532 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1283331012533 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1283331012534 NAD(P) binding site [chemical binding]; other site 1283331012535 catalytic residues [active] 1283331012536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331012537 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331012538 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331012539 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283331012540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283331012541 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1283331012542 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283331012543 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283331012544 putative active site [active] 1283331012545 putative NTP binding site [chemical binding]; other site 1283331012546 putative nucleic acid binding site [nucleotide binding]; other site 1283331012547 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1283331012548 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1283331012549 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1283331012550 G1 box; other site 1283331012551 putative GEF interaction site [polypeptide binding]; other site 1283331012552 GTP/Mg2+ binding site [chemical binding]; other site 1283331012553 Switch I region; other site 1283331012554 G2 box; other site 1283331012555 G3 box; other site 1283331012556 Switch II region; other site 1283331012557 G4 box; other site 1283331012558 G5 box; other site 1283331012559 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1283331012560 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1283331012561 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1283331012562 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1283331012563 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1283331012564 Ligand Binding Site [chemical binding]; other site 1283331012565 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1283331012566 active site residue [active] 1283331012567 glutamine synthetase; Provisional; Region: glnA; PRK09469 1283331012568 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1283331012569 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1283331012570 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1283331012571 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1283331012572 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1283331012573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331012574 dimer interface [polypeptide binding]; other site 1283331012575 phosphorylation site [posttranslational modification] 1283331012576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331012577 ATP binding site [chemical binding]; other site 1283331012578 Mg2+ binding site [ion binding]; other site 1283331012579 G-X-G motif; other site 1283331012580 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1283331012581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331012582 active site 1283331012583 phosphorylation site [posttranslational modification] 1283331012584 intermolecular recognition site; other site 1283331012585 dimerization interface [polypeptide binding]; other site 1283331012586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331012587 Walker A motif; other site 1283331012588 ATP binding site [chemical binding]; other site 1283331012589 Walker B motif; other site 1283331012590 arginine finger; other site 1283331012591 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331012592 peroxiredoxin; Region: AhpC; TIGR03137 1283331012593 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1283331012594 dimer interface [polypeptide binding]; other site 1283331012595 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1283331012596 catalytic triad [active] 1283331012597 peroxidatic and resolving cysteines [active] 1283331012598 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1283331012599 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1283331012600 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283331012601 active site 1283331012602 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1283331012603 AAA domain; Region: AAA_26; pfam13500 1283331012604 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1283331012605 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1283331012606 dimer interface [polypeptide binding]; other site 1283331012607 FMN binding site [chemical binding]; other site 1283331012608 NADPH bind site [chemical binding]; other site 1283331012609 flavodoxin FldA; Validated; Region: PRK09267 1283331012610 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1283331012611 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1283331012612 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1283331012613 active site 1283331012614 HIGH motif; other site 1283331012615 dimer interface [polypeptide binding]; other site 1283331012616 KMSKS motif; other site 1283331012617 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1283331012618 putative peptidase; Provisional; Region: PRK11649 1283331012619 Peptidase family M23; Region: Peptidase_M23; pfam01551 1283331012620 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1283331012621 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283331012622 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283331012623 putative active site [active] 1283331012624 putative NTP binding site [chemical binding]; other site 1283331012625 putative nucleic acid binding site [nucleotide binding]; other site 1283331012626 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1283331012627 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1283331012628 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1283331012629 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283331012630 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1283331012631 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1283331012632 nucleotide binding site/active site [active] 1283331012633 HIT family signature motif; other site 1283331012634 catalytic residue [active] 1283331012635 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1283331012636 diiron binding motif [ion binding]; other site 1283331012637 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1283331012638 OsmC-like protein; Region: OsmC; cl00767 1283331012639 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1283331012640 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1283331012641 ligand binding site [chemical binding]; other site 1283331012642 flexible hinge region; other site 1283331012643 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1283331012644 putative switch regulator; other site 1283331012645 non-specific DNA interactions [nucleotide binding]; other site 1283331012646 DNA binding site [nucleotide binding] 1283331012647 sequence specific DNA binding site [nucleotide binding]; other site 1283331012648 putative cAMP binding site [chemical binding]; other site 1283331012649 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1283331012650 active site 1283331012651 ribulose/triose binding site [chemical binding]; other site 1283331012652 phosphate binding site [ion binding]; other site 1283331012653 substrate (anthranilate) binding pocket [chemical binding]; other site 1283331012654 product (indole) binding pocket [chemical binding]; other site 1283331012655 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1283331012656 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1283331012657 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1283331012658 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1283331012659 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1283331012660 glutamine binding [chemical binding]; other site 1283331012661 catalytic triad [active] 1283331012662 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1283331012663 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1283331012664 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1283331012665 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1283331012666 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1283331012667 alpha subunit interface [polypeptide binding]; other site 1283331012668 TPP binding site [chemical binding]; other site 1283331012669 heterodimer interface [polypeptide binding]; other site 1283331012670 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283331012671 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1283331012672 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1283331012673 tetramer interface [polypeptide binding]; other site 1283331012674 TPP-binding site [chemical binding]; other site 1283331012675 heterodimer interface [polypeptide binding]; other site 1283331012676 phosphorylation loop region [posttranslational modification] 1283331012677 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1283331012678 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1283331012679 DNA binding residues [nucleotide binding] 1283331012680 dimer interface [polypeptide binding]; other site 1283331012681 putative metal binding site [ion binding]; other site 1283331012682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1283331012683 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1283331012684 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1283331012685 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331012686 active site 1283331012687 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1283331012688 catalytic triad [active] 1283331012689 metal binding site [ion binding]; metal-binding site 1283331012690 conserved cis-peptide bond; other site 1283331012691 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1283331012692 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1283331012693 active site 1283331012694 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1283331012695 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1283331012696 putative active site [active] 1283331012697 putative metal binding site [ion binding]; other site 1283331012698 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1283331012699 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 1283331012700 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1283331012701 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1283331012702 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1283331012703 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1283331012704 DNA binding site [nucleotide binding] 1283331012705 active site 1283331012706 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1283331012707 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1283331012708 catalytic site [active] 1283331012709 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1283331012710 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1283331012711 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1283331012712 protein binding site [polypeptide binding]; other site 1283331012713 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1283331012714 active site 1283331012715 catalytic residues [active] 1283331012716 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1283331012717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331012718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331012719 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1283331012720 putative substrate binding pocket [chemical binding]; other site 1283331012721 putative dimerization interface [polypeptide binding]; other site 1283331012722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331012723 putative substrate translocation pore; other site 1283331012724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331012725 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1283331012726 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283331012727 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331012728 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1283331012729 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283331012730 Ligand Binding Site [chemical binding]; other site 1283331012731 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1283331012732 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1283331012733 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1283331012734 dimer interaction site [polypeptide binding]; other site 1283331012735 substrate-binding tunnel; other site 1283331012736 active site 1283331012737 catalytic site [active] 1283331012738 substrate binding site [chemical binding]; other site 1283331012739 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1283331012740 oligomerization interface [polypeptide binding]; other site 1283331012741 active site 1283331012742 metal binding site [ion binding]; metal-binding site 1283331012743 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1283331012744 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1283331012745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331012746 putative DNA binding site [nucleotide binding]; other site 1283331012747 putative Zn2+ binding site [ion binding]; other site 1283331012748 AsnC family; Region: AsnC_trans_reg; pfam01037 1283331012749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331012750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331012751 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1283331012752 putative dimerization interface [polypeptide binding]; other site 1283331012753 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1283331012754 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1283331012755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283331012756 TPR motif; other site 1283331012757 binding surface 1283331012758 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1283331012759 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1283331012760 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1283331012761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331012762 active site 1283331012763 phosphorylation site [posttranslational modification] 1283331012764 intermolecular recognition site; other site 1283331012765 dimerization interface [polypeptide binding]; other site 1283331012766 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331012767 DNA binding site [nucleotide binding] 1283331012768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331012769 dimerization interface [polypeptide binding]; other site 1283331012770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331012771 dimer interface [polypeptide binding]; other site 1283331012772 phosphorylation site [posttranslational modification] 1283331012773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331012774 ATP binding site [chemical binding]; other site 1283331012775 Mg2+ binding site [ion binding]; other site 1283331012776 G-X-G motif; other site 1283331012777 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1283331012778 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1283331012779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1283331012780 anthranilate synthase component I; Provisional; Region: PRK13565 1283331012781 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1283331012782 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1283331012783 putative active site [active] 1283331012784 anthranilate synthase component I; Provisional; Region: PRK13565 1283331012785 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1283331012786 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1283331012787 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 1283331012788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331012789 motif II; other site 1283331012790 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1283331012791 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1283331012792 substrate binding site [chemical binding]; other site 1283331012793 hexamer interface [polypeptide binding]; other site 1283331012794 metal binding site [ion binding]; metal-binding site 1283331012795 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1283331012796 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283331012797 inhibitor-cofactor binding pocket; inhibition site 1283331012798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331012799 catalytic residue [active] 1283331012800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331012801 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283331012802 dimerization interface [polypeptide binding]; other site 1283331012803 substrate binding pocket [chemical binding]; other site 1283331012804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283331012805 active site 1283331012806 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1283331012807 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1283331012808 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1283331012809 shikimate binding site; other site 1283331012810 NAD(P) binding site [chemical binding]; other site 1283331012811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331012812 putative substrate translocation pore; other site 1283331012813 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1283331012814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331012815 D-galactonate transporter; Region: 2A0114; TIGR00893 1283331012816 putative substrate translocation pore; other site 1283331012817 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1283331012818 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 1283331012819 NADP binding site [chemical binding]; other site 1283331012820 homodimer interface [polypeptide binding]; other site 1283331012821 active site 1283331012822 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1283331012823 putative metal binding site [ion binding]; other site 1283331012824 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1283331012825 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1283331012826 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1283331012827 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1283331012828 Substrate binding site; other site 1283331012829 metal-binding site 1283331012830 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1283331012831 Phosphotransferase enzyme family; Region: APH; pfam01636 1283331012832 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1283331012833 OstA-like protein; Region: OstA; cl00844 1283331012834 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1283331012835 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1283331012836 SurA N-terminal domain; Region: SurA_N; pfam09312 1283331012837 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1283331012838 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1283331012839 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1283331012840 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1283331012841 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1283331012842 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1283331012843 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1283331012844 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1283331012845 active site 1283331012846 metal binding site [ion binding]; metal-binding site 1283331012847 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1283331012848 active site residue [active] 1283331012849 PrkA family serine protein kinase; Provisional; Region: PRK15455 1283331012850 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1283331012851 hypothetical protein; Provisional; Region: PRK05325 1283331012852 SpoVR family protein; Provisional; Region: PRK11767 1283331012853 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1283331012854 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1283331012855 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1283331012856 active site 1283331012857 NTP binding site [chemical binding]; other site 1283331012858 metal binding triad [ion binding]; metal-binding site 1283331012859 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1283331012860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283331012861 Zn2+ binding site [ion binding]; other site 1283331012862 Mg2+ binding site [ion binding]; other site 1283331012863 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1283331012864 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1283331012865 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1283331012866 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1283331012867 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1283331012868 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1283331012869 active site residue [active] 1283331012870 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1283331012871 catalytic center binding site [active] 1283331012872 ATP binding site [chemical binding]; other site 1283331012873 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1283331012874 active site 1283331012875 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1283331012876 UGMP family protein; Validated; Region: PRK09604 1283331012877 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1283331012878 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1283331012879 DNA primase; Validated; Region: dnaG; PRK05667 1283331012880 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1283331012881 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1283331012882 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1283331012883 active site 1283331012884 metal binding site [ion binding]; metal-binding site 1283331012885 interdomain interaction site; other site 1283331012886 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1283331012887 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1283331012888 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1283331012889 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1283331012890 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1283331012891 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1283331012892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331012893 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1283331012894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331012895 DNA binding residues [nucleotide binding] 1283331012896 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1283331012897 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1283331012898 ligand binding site [chemical binding]; other site 1283331012899 flexible hinge region; other site 1283331012900 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1283331012901 putative switch regulator; other site 1283331012902 non-specific DNA interactions [nucleotide binding]; other site 1283331012903 DNA binding site [nucleotide binding] 1283331012904 sequence specific DNA binding site [nucleotide binding]; other site 1283331012905 putative cAMP binding site [chemical binding]; other site 1283331012906 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1283331012907 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1283331012908 Repair protein; Region: Repair_PSII; pfam04536 1283331012909 Repair protein; Region: Repair_PSII; cl01535 1283331012910 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1283331012911 Competence-damaged protein; Region: CinA; pfam02464 1283331012912 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1283331012913 dimanganese center [ion binding]; other site 1283331012914 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283331012915 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1283331012916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331012917 Walker A motif; other site 1283331012918 ATP binding site [chemical binding]; other site 1283331012919 Walker B motif; other site 1283331012920 arginine finger; other site 1283331012921 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331012922 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1283331012923 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283331012924 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1283331012925 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1283331012926 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1283331012927 putative ligand binding residues [chemical binding]; other site 1283331012928 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1283331012929 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1283331012930 ABC-ATPase subunit interface; other site 1283331012931 dimer interface [polypeptide binding]; other site 1283331012932 putative PBP binding regions; other site 1283331012933 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1283331012934 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1283331012935 Walker A/P-loop; other site 1283331012936 ATP binding site [chemical binding]; other site 1283331012937 Q-loop/lid; other site 1283331012938 ABC transporter signature motif; other site 1283331012939 Walker B; other site 1283331012940 D-loop; other site 1283331012941 H-loop/switch region; other site 1283331012942 RNA polymerase sigma factor; Provisional; Region: PRK12528 1283331012943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331012944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331012945 DNA binding residues [nucleotide binding] 1283331012946 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283331012947 FecR protein; Region: FecR; pfam04773 1283331012948 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1283331012949 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283331012950 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331012951 N-terminal plug; other site 1283331012952 ligand-binding site [chemical binding]; other site 1283331012953 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1283331012954 CGNR zinc finger; Region: zf-CGNR; pfam11706 1283331012955 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283331012956 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1283331012957 Predicted membrane protein [Function unknown]; Region: COG3212 1283331012958 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1283331012959 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 1283331012960 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1283331012961 putative FMN binding site [chemical binding]; other site 1283331012962 glycine dehydrogenase; Provisional; Region: PRK05367 1283331012963 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1283331012964 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283331012965 catalytic residue [active] 1283331012966 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1283331012967 tetramer interface [polypeptide binding]; other site 1283331012968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331012969 catalytic residue [active] 1283331012970 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1283331012971 lipoyl attachment site [posttranslational modification]; other site 1283331012972 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1283331012973 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1283331012974 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1283331012975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331012976 dimer interface [polypeptide binding]; other site 1283331012977 conserved gate region; other site 1283331012978 putative PBP binding loops; other site 1283331012979 ABC-ATPase subunit interface; other site 1283331012980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331012981 dimer interface [polypeptide binding]; other site 1283331012982 conserved gate region; other site 1283331012983 putative PBP binding loops; other site 1283331012984 ABC-ATPase subunit interface; other site 1283331012985 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1283331012986 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1283331012987 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 1283331012988 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1283331012989 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1283331012990 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1283331012991 proline aminopeptidase P II; Provisional; Region: PRK10879 1283331012992 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1283331012993 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1283331012994 active site 1283331012995 hypothetical protein; Reviewed; Region: PRK02166 1283331012996 TIGR02449 family protein; Region: TIGR02449 1283331012997 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 1283331012998 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1283331012999 EVE domain; Region: EVE; cl00728 1283331013000 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1283331013001 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283331013002 catalytic loop [active] 1283331013003 iron binding site [ion binding]; other site 1283331013004 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1283331013005 FAD binding pocket [chemical binding]; other site 1283331013006 FAD binding motif [chemical binding]; other site 1283331013007 phosphate binding motif [ion binding]; other site 1283331013008 beta-alpha-beta structure motif; other site 1283331013009 NAD binding pocket [chemical binding]; other site 1283331013010 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1283331013011 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1283331013012 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1283331013013 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1283331013014 RNA binding site [nucleotide binding]; other site 1283331013015 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1283331013016 multimer interface [polypeptide binding]; other site 1283331013017 Walker A motif; other site 1283331013018 ATP binding site [chemical binding]; other site 1283331013019 Walker B motif; other site 1283331013020 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1283331013021 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1283331013022 catalytic residues [active] 1283331013023 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1283331013024 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1283331013025 polyphosphate kinase; Provisional; Region: PRK05443 1283331013026 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1283331013027 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1283331013028 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1283331013029 putative domain interface [polypeptide binding]; other site 1283331013030 putative active site [active] 1283331013031 catalytic site [active] 1283331013032 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1283331013033 putative domain interface [polypeptide binding]; other site 1283331013034 putative active site [active] 1283331013035 catalytic site [active] 1283331013036 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1283331013037 dimer interface [polypeptide binding]; other site 1283331013038 allosteric magnesium binding site [ion binding]; other site 1283331013039 active site 1283331013040 aspartate-rich active site metal binding site; other site 1283331013041 Schiff base residues; other site 1283331013042 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1283331013043 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1283331013044 conserved cys residue [active] 1283331013045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1283331013046 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1283331013047 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1283331013048 G1 box; other site 1283331013049 GTP/Mg2+ binding site [chemical binding]; other site 1283331013050 Switch I region; other site 1283331013051 G2 box; other site 1283331013052 G3 box; other site 1283331013053 Switch II region; other site 1283331013054 G4 box; other site 1283331013055 G5 box; other site 1283331013056 Nucleoside recognition; Region: Gate; pfam07670 1283331013057 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1283331013058 Nucleoside recognition; Region: Gate; pfam07670 1283331013059 FeoA domain; Region: FeoA; pfam04023 1283331013060 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1283331013061 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1283331013062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283331013063 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283331013064 ABC transporter; Region: ABC_tran_2; pfam12848 1283331013065 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283331013066 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1283331013067 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 1283331013068 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; pfam04353 1283331013069 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1283331013070 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 1283331013071 HemY protein N-terminus; Region: HemY_N; pfam07219 1283331013072 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1283331013073 uroporphyrinogen-III synthase; Validated; Region: PRK05752 1283331013074 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1283331013075 active site 1283331013076 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1283331013077 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1283331013078 domain interfaces; other site 1283331013079 active site 1283331013080 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1283331013081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331013082 active site 1283331013083 phosphorylation site [posttranslational modification] 1283331013084 intermolecular recognition site; other site 1283331013085 dimerization interface [polypeptide binding]; other site 1283331013086 LytTr DNA-binding domain; Region: LytTR; pfam04397 1283331013087 argininosuccinate lyase; Provisional; Region: PRK00855 1283331013088 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1283331013089 active sites [active] 1283331013090 tetramer interface [polypeptide binding]; other site 1283331013091 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1283331013092 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1283331013093 Cl binding site [ion binding]; other site 1283331013094 oligomer interface [polypeptide binding]; other site 1283331013095 TIGR02647 family protein; Region: DNA 1283331013096 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1283331013097 putative iron binding site [ion binding]; other site 1283331013098 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 1283331013099 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1283331013100 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1283331013101 active site 1283331013102 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283331013103 substrate binding site [chemical binding]; other site 1283331013104 catalytic residues [active] 1283331013105 dimer interface [polypeptide binding]; other site 1283331013106 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1283331013107 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1283331013108 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1283331013109 Protein of unknown function, DUF484; Region: DUF484; cl17449 1283331013110 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1283331013111 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1283331013112 active site 1283331013113 DNA binding site [nucleotide binding] 1283331013114 Int/Topo IB signature motif; other site 1283331013115 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1283331013116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283331013117 motif II; other site 1283331013118 CAAX protease self-immunity; Region: Abi; pfam02517 1283331013119 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1283331013120 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1283331013121 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1283331013122 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1283331013123 Membrane fusogenic activity; Region: BMFP; pfam04380 1283331013124 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1283331013125 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1283331013126 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1283331013127 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1283331013128 Predicted ATPase [General function prediction only]; Region: COG4637 1283331013129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331013130 Walker A/P-loop; other site 1283331013131 ATP binding site [chemical binding]; other site 1283331013132 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331013133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331013134 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283331013135 putative effector binding pocket; other site 1283331013136 dimerization interface [polypeptide binding]; other site 1283331013137 Predicted membrane protein [Function unknown]; Region: COG2259 1283331013138 Pirin-related protein [General function prediction only]; Region: COG1741 1283331013139 Pirin; Region: Pirin; pfam02678 1283331013140 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1283331013141 Part of AAA domain; Region: AAA_19; pfam13245 1283331013142 Family description; Region: UvrD_C_2; pfam13538 1283331013143 Staphylococcal nuclease homologues; Region: SNc; smart00318 1283331013144 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1283331013145 Catalytic site; other site 1283331013146 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1283331013147 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1283331013148 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1283331013149 putative heme binding pocket [chemical binding]; other site 1283331013150 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283331013151 active site 1283331013152 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1283331013153 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1283331013154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331013155 non-specific DNA binding site [nucleotide binding]; other site 1283331013156 salt bridge; other site 1283331013157 sequence-specific DNA binding site [nucleotide binding]; other site 1283331013158 Cupin domain; Region: Cupin_2; pfam07883 1283331013159 alanine racemase; Reviewed; Region: dadX; PRK03646 1283331013160 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1283331013161 active site 1283331013162 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283331013163 substrate binding site [chemical binding]; other site 1283331013164 catalytic residues [active] 1283331013165 dimer interface [polypeptide binding]; other site 1283331013166 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1283331013167 homotrimer interaction site [polypeptide binding]; other site 1283331013168 putative active site [active] 1283331013169 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1283331013170 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283331013171 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1283331013172 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1283331013173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331013174 putative DNA binding site [nucleotide binding]; other site 1283331013175 putative Zn2+ binding site [ion binding]; other site 1283331013176 AsnC family; Region: AsnC_trans_reg; pfam01037 1283331013177 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1283331013178 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1283331013179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283331013180 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1283331013181 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1283331013182 NAD(P) binding site [chemical binding]; other site 1283331013183 catalytic residues [active] 1283331013184 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1283331013185 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1283331013186 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1283331013187 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1283331013188 peptide binding site [polypeptide binding]; other site 1283331013189 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1283331013190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283331013191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283331013192 DNA binding residues [nucleotide binding] 1283331013193 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1283331013194 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1283331013195 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1283331013196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331013197 Walker A/P-loop; other site 1283331013198 ATP binding site [chemical binding]; other site 1283331013199 Q-loop/lid; other site 1283331013200 ABC transporter signature motif; other site 1283331013201 Walker B; other site 1283331013202 D-loop; other site 1283331013203 H-loop/switch region; other site 1283331013204 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1283331013205 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1283331013206 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1283331013207 P loop; other site 1283331013208 GTP binding site [chemical binding]; other site 1283331013209 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1283331013210 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1283331013211 folate binding site [chemical binding]; other site 1283331013212 NADP+ binding site [chemical binding]; other site 1283331013213 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1283331013214 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 1283331013215 putative active site [active] 1283331013216 catalytic site [active] 1283331013217 putative metal binding site [ion binding]; other site 1283331013218 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1283331013219 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1283331013220 G1 box; other site 1283331013221 GTP/Mg2+ binding site [chemical binding]; other site 1283331013222 G2 box; other site 1283331013223 Switch I region; other site 1283331013224 G3 box; other site 1283331013225 Switch II region; other site 1283331013226 G4 box; other site 1283331013227 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1283331013228 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1283331013229 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1283331013230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283331013231 DNA-binding site [nucleotide binding]; DNA binding site 1283331013232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283331013233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331013234 homodimer interface [polypeptide binding]; other site 1283331013235 catalytic residue [active] 1283331013236 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1283331013237 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1283331013238 dimerization interface [polypeptide binding]; other site 1283331013239 active site 1283331013240 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1283331013241 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283331013242 NRDE protein; Region: NRDE; cl01315 1283331013243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331013244 PAS fold; Region: PAS_3; pfam08447 1283331013245 putative active site [active] 1283331013246 heme pocket [chemical binding]; other site 1283331013247 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331013248 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331013249 metal binding site [ion binding]; metal-binding site 1283331013250 active site 1283331013251 I-site; other site 1283331013252 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1283331013253 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283331013254 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1283331013255 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1283331013256 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1283331013257 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1283331013258 putative active site [active] 1283331013259 Ap4A binding site [chemical binding]; other site 1283331013260 nudix motif; other site 1283331013261 putative metal binding site [ion binding]; other site 1283331013262 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1283331013263 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1283331013264 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1283331013265 threonine dehydratase; Reviewed; Region: PRK09224 1283331013266 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1283331013267 tetramer interface [polypeptide binding]; other site 1283331013268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331013269 catalytic residue [active] 1283331013270 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1283331013271 putative Ile/Val binding site [chemical binding]; other site 1283331013272 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1283331013273 putative Ile/Val binding site [chemical binding]; other site 1283331013274 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1283331013275 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1283331013276 active site 1283331013277 dimer interface [polypeptide binding]; other site 1283331013278 SdiA-regulated; Region: SdiA-regulated; pfam06977 1283331013279 SdiA-regulated; Region: SdiA-regulated; cd09971 1283331013280 putative active site [active] 1283331013281 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283331013282 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1283331013283 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1283331013284 FAD binding domain; Region: FAD_binding_4; pfam01565 1283331013285 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1283331013286 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1283331013287 ligand binding site [chemical binding]; other site 1283331013288 NAD binding site [chemical binding]; other site 1283331013289 tetramer interface [polypeptide binding]; other site 1283331013290 catalytic site [active] 1283331013291 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1283331013292 L-serine binding site [chemical binding]; other site 1283331013293 ACT domain interface; other site 1283331013294 Predicted permeases [General function prediction only]; Region: COG0679 1283331013295 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1283331013296 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1283331013297 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1283331013298 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1283331013299 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 1283331013300 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1283331013301 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1283331013302 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283331013303 monoglyceride lipase; Provisional; Region: PHA02857 1283331013304 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1283331013305 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1283331013306 putative NAD(P) binding site [chemical binding]; other site 1283331013307 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1283331013308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331013309 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1283331013310 dimerization interface [polypeptide binding]; other site 1283331013311 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1283331013312 Y-family of DNA polymerases; Region: PolY; cl12025 1283331013313 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1283331013314 generic binding surface II; other site 1283331013315 ssDNA binding site; other site 1283331013316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283331013317 ATP binding site [chemical binding]; other site 1283331013318 putative Mg++ binding site [ion binding]; other site 1283331013319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331013320 nucleotide binding region [chemical binding]; other site 1283331013321 ATP-binding site [chemical binding]; other site 1283331013322 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1283331013323 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1283331013324 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1283331013325 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283331013326 IHF dimer interface [polypeptide binding]; other site 1283331013327 IHF - DNA interface [nucleotide binding]; other site 1283331013328 Rubredoxin [Energy production and conversion]; Region: COG1773 1283331013329 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1283331013330 iron binding site [ion binding]; other site 1283331013331 Chorismate lyase; Region: Chor_lyase; cl01230 1283331013332 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1283331013333 UbiA prenyltransferase family; Region: UbiA; pfam01040 1283331013334 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1283331013335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331013336 active site 1283331013337 phosphorylation site [posttranslational modification] 1283331013338 intermolecular recognition site; other site 1283331013339 dimerization interface [polypeptide binding]; other site 1283331013340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331013341 DNA binding site [nucleotide binding] 1283331013342 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1283331013343 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1283331013344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331013345 putative active site [active] 1283331013346 heme pocket [chemical binding]; other site 1283331013347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331013348 dimer interface [polypeptide binding]; other site 1283331013349 phosphorylation site [posttranslational modification] 1283331013350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331013351 ATP binding site [chemical binding]; other site 1283331013352 Mg2+ binding site [ion binding]; other site 1283331013353 G-X-G motif; other site 1283331013354 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1283331013355 Domain of unknown function DUF21; Region: DUF21; pfam01595 1283331013356 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1283331013357 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1283331013358 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1283331013359 Peptidase family M23; Region: Peptidase_M23; pfam01551 1283331013360 transcriptional regulator PhoU; Provisional; Region: PRK11115 1283331013361 PhoU domain; Region: PhoU; pfam01895 1283331013362 PhoU domain; Region: PhoU; pfam01895 1283331013363 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1283331013364 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1283331013365 Walker A/P-loop; other site 1283331013366 ATP binding site [chemical binding]; other site 1283331013367 Q-loop/lid; other site 1283331013368 ABC transporter signature motif; other site 1283331013369 Walker B; other site 1283331013370 D-loop; other site 1283331013371 H-loop/switch region; other site 1283331013372 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1283331013373 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1283331013374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331013375 dimer interface [polypeptide binding]; other site 1283331013376 conserved gate region; other site 1283331013377 putative PBP binding loops; other site 1283331013378 ABC-ATPase subunit interface; other site 1283331013379 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1283331013380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331013381 ABC-ATPase subunit interface; other site 1283331013382 PBP superfamily domain; Region: PBP_like_2; cl17296 1283331013383 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1283331013384 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1283331013385 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1283331013386 active site 1283331013387 phosphate binding residues; other site 1283331013388 catalytic residues [active] 1283331013389 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1283331013390 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 1283331013391 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283331013392 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283331013393 ligand binding site [chemical binding]; other site 1283331013394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331013395 S-adenosylmethionine binding site [chemical binding]; other site 1283331013396 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1283331013397 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1283331013398 NADPH bind site [chemical binding]; other site 1283331013399 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1283331013400 putative FMN binding site [chemical binding]; other site 1283331013401 NADPH bind site [chemical binding]; other site 1283331013402 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1283331013403 active site residue [active] 1283331013404 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1283331013405 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1283331013406 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1283331013407 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1283331013408 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1283331013409 C-terminal domain interface [polypeptide binding]; other site 1283331013410 GSH binding site (G-site) [chemical binding]; other site 1283331013411 dimer interface [polypeptide binding]; other site 1283331013412 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1283331013413 dimer interface [polypeptide binding]; other site 1283331013414 substrate binding pocket (H-site) [chemical binding]; other site 1283331013415 N-terminal domain interface [polypeptide binding]; other site 1283331013416 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1283331013417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331013418 dimer interface [polypeptide binding]; other site 1283331013419 conserved gate region; other site 1283331013420 putative PBP binding loops; other site 1283331013421 ABC-ATPase subunit interface; other site 1283331013422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331013423 dimer interface [polypeptide binding]; other site 1283331013424 conserved gate region; other site 1283331013425 putative PBP binding loops; other site 1283331013426 ABC-ATPase subunit interface; other site 1283331013427 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1283331013428 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1283331013429 Walker A/P-loop; other site 1283331013430 ATP binding site [chemical binding]; other site 1283331013431 Q-loop/lid; other site 1283331013432 ABC transporter signature motif; other site 1283331013433 Walker B; other site 1283331013434 D-loop; other site 1283331013435 H-loop/switch region; other site 1283331013436 TOBE domain; Region: TOBE_2; pfam08402 1283331013437 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1283331013438 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1283331013439 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1283331013440 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1283331013441 active site 1283331013442 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283331013443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283331013444 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283331013445 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1283331013446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283331013447 S-adenosylmethionine binding site [chemical binding]; other site 1283331013448 Predicted transcriptional regulator [Transcription]; Region: COG2944 1283331013449 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283331013450 non-specific DNA binding site [nucleotide binding]; other site 1283331013451 salt bridge; other site 1283331013452 sequence-specific DNA binding site [nucleotide binding]; other site 1283331013453 putative aminotransferase; Validated; Region: PRK07480 1283331013454 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283331013455 inhibitor-cofactor binding pocket; inhibition site 1283331013456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283331013457 catalytic residue [active] 1283331013458 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1283331013459 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1283331013460 Peptidase C26; Region: Peptidase_C26; pfam07722 1283331013461 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1283331013462 catalytic triad [active] 1283331013463 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1283331013464 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1283331013465 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1283331013466 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1283331013467 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1283331013468 putative active site; other site 1283331013469 catalytic triad [active] 1283331013470 putative dimer interface [polypeptide binding]; other site 1283331013471 agmatine deiminase; Provisional; Region: PRK13551 1283331013472 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1283331013473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331013474 dimerization interface [polypeptide binding]; other site 1283331013475 putative DNA binding site [nucleotide binding]; other site 1283331013476 putative Zn2+ binding site [ion binding]; other site 1283331013477 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331013478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331013479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331013480 metal binding site [ion binding]; metal-binding site 1283331013481 active site 1283331013482 I-site; other site 1283331013483 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1283331013484 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1283331013485 Di-iron ligands [ion binding]; other site 1283331013486 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1283331013487 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1283331013488 putative active site pocket [active] 1283331013489 dimerization interface [polypeptide binding]; other site 1283331013490 putative catalytic residue [active] 1283331013491 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582 1283331013492 Nitrogenase_VFe_beta -like: Nitrogenase VFe protein, beta subunit like. This group contains proteins similar to the beta subunits of the VFe protein of the vanadium-dependent (V-) nitrogenase. Nitrogenase catalyzes the ATP-dependent reduction of...; Region: Nitrogenase_VFe_beta_like; cd01973 1283331013493 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1283331013494 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 1283331013495 nitrogenase iron-iron protein, alpha chain; Region: ANFD; TIGR01861 1283331013496 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 1283331013497 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142 1283331013498 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1283331013499 Nucleotide-binding sites [chemical binding]; other site 1283331013500 Walker A motif; other site 1283331013501 Switch I region of nucleotide binding site; other site 1283331013502 Fe4S4 binding sites [ion binding]; other site 1283331013503 Switch II region of nucleotide binding site; other site 1283331013504 Nif-specific regulatory protein; Region: nifA; TIGR01817 1283331013505 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283331013506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331013507 Walker A motif; other site 1283331013508 ATP binding site [chemical binding]; other site 1283331013509 Walker B motif; other site 1283331013510 arginine finger; other site 1283331013511 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331013512 NifU-like domain; Region: NifU; cl00484 1283331013513 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1283331013514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331013515 PAS domain; Region: PAS_9; pfam13426 1283331013516 putative active site [active] 1283331013517 heme pocket [chemical binding]; other site 1283331013518 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331013519 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331013520 metal binding site [ion binding]; metal-binding site 1283331013521 active site 1283331013522 I-site; other site 1283331013523 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283331013524 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 1283331013525 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1283331013526 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1283331013527 tetramerization interface [polypeptide binding]; other site 1283331013528 NAD(P) binding site [chemical binding]; other site 1283331013529 catalytic residues [active] 1283331013530 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1283331013531 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1283331013532 OsmC-like protein; Region: OsmC; pfam02566 1283331013533 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331013534 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331013535 active site 1283331013536 catalytic tetrad [active] 1283331013537 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1283331013538 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1283331013539 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1283331013540 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331013541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331013542 metal binding site [ion binding]; metal-binding site 1283331013543 active site 1283331013544 I-site; other site 1283331013545 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283331013546 PGAP1-like protein; Region: PGAP1; pfam07819 1283331013547 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283331013548 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1283331013549 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283331013550 ligand binding site [chemical binding]; other site 1283331013551 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1283331013552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283331013553 DNA-binding site [nucleotide binding]; DNA binding site 1283331013554 FCD domain; Region: FCD; pfam07729 1283331013555 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1283331013556 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1283331013557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331013558 putative substrate translocation pore; other site 1283331013559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1283331013560 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1283331013561 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1283331013562 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1283331013563 dimer interface [polypeptide binding]; other site 1283331013564 NADP binding site [chemical binding]; other site 1283331013565 catalytic residues [active] 1283331013566 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331013567 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331013568 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1283331013569 active sites [active] 1283331013570 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 1283331013571 tetramer interface [polypeptide binding]; other site 1283331013572 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1283331013573 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1283331013574 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1283331013575 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331013576 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1283331013577 putative dimerization interface [polypeptide binding]; other site 1283331013578 putative substrate binding pocket [chemical binding]; other site 1283331013579 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013580 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013581 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013582 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013583 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013584 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013585 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1283331013586 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013587 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013588 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013589 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013590 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013591 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013592 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283331013593 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283331013594 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283331013595 Right handed beta helix region; Region: Beta_helix; pfam13229 1283331013596 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283331013597 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1283331013598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283331013599 HAMP domain; Region: HAMP; pfam00672 1283331013600 dimerization interface [polypeptide binding]; other site 1283331013601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283331013602 dimer interface [polypeptide binding]; other site 1283331013603 phosphorylation site [posttranslational modification] 1283331013604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331013605 ATP binding site [chemical binding]; other site 1283331013606 Mg2+ binding site [ion binding]; other site 1283331013607 G-X-G motif; other site 1283331013608 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1283331013609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283331013610 active site 1283331013611 phosphorylation site [posttranslational modification] 1283331013612 intermolecular recognition site; other site 1283331013613 dimerization interface [polypeptide binding]; other site 1283331013614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283331013615 DNA binding site [nucleotide binding] 1283331013616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1283331013617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1283331013618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1283331013619 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1283331013620 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1283331013621 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1283331013622 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1283331013623 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1283331013624 active site 1283331013625 catalytic residues [active] 1283331013626 metal binding site [ion binding]; metal-binding site 1283331013627 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1283331013628 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1283331013629 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1283331013630 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1283331013631 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1283331013632 carboxyltransferase (CT) interaction site; other site 1283331013633 biotinylation site [posttranslational modification]; other site 1283331013634 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 1283331013635 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283331013636 substrate binding site [chemical binding]; other site 1283331013637 oxyanion hole (OAH) forming residues; other site 1283331013638 trimer interface [polypeptide binding]; other site 1283331013639 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1283331013640 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1283331013641 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1283331013642 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1283331013643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283331013644 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1283331013645 substrate binding site [chemical binding]; other site 1283331013646 FAD binding site [chemical binding]; other site 1283331013647 catalytic base [active] 1283331013648 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1283331013649 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1283331013650 DNA binding residues [nucleotide binding] 1283331013651 putative dimer interface [polypeptide binding]; other site 1283331013652 outer membrane porin, OprD family; Region: OprD; pfam03573 1283331013653 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1283331013654 Citrate transporter; Region: CitMHS; pfam03600 1283331013655 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1283331013656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1283331013657 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1283331013658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1283331013659 DNA binding site [nucleotide binding] 1283331013660 DNA-binding interface [nucleotide binding]; DNA binding site 1283331013661 domain linker motif; other site 1283331013662 Integrase core domain; Region: rve; pfam00665 1283331013663 Integrase core domain; Region: rve_3; cl15866 1283331013664 transposase/IS protein; Provisional; Region: PRK09183 1283331013665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331013666 Walker A motif; other site 1283331013667 ATP binding site [chemical binding]; other site 1283331013668 Walker B motif; other site 1283331013669 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1283331013670 non-specific DNA binding site [nucleotide binding]; other site 1283331013671 salt bridge; other site 1283331013672 sequence-specific DNA binding site [nucleotide binding]; other site 1283331013673 Winged helix-turn helix; Region: HTH_29; pfam13551 1283331013674 Homeodomain-like domain; Region: HTH_32; pfam13565 1283331013675 Fic family protein [Function unknown]; Region: COG3177 1283331013676 Fic/DOC family; Region: Fic; pfam02661 1283331013677 Transposase domain (DUF772); Region: DUF772; pfam05598 1283331013678 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283331013679 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283331013680 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1283331013681 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 1283331013682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1283331013683 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1283331013684 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1283331013685 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1283331013686 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283331013687 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283331013688 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1283331013689 30S subunit binding site; other site 1283331013690 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1283331013691 DNA-binding site [nucleotide binding]; DNA binding site 1283331013692 RNA-binding motif; other site 1283331013693 H+ Antiporter protein; Region: 2A0121; TIGR00900 1283331013694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331013695 putative substrate translocation pore; other site 1283331013696 Predicted permeases [General function prediction only]; Region: COG0679 1283331013697 triosephosphate isomerase; Provisional; Region: PRK14567 1283331013698 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1283331013699 substrate binding site [chemical binding]; other site 1283331013700 dimer interface [polypeptide binding]; other site 1283331013701 catalytic triad [active] 1283331013702 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1283331013703 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1283331013704 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1283331013705 putative active site [active] 1283331013706 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1283331013707 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1283331013708 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283331013709 tetrameric interface [polypeptide binding]; other site 1283331013710 activator binding site; other site 1283331013711 NADP binding site [chemical binding]; other site 1283331013712 substrate binding site [chemical binding]; other site 1283331013713 catalytic residues [active] 1283331013714 triosephosphate isomerase; Provisional; Region: PRK14567 1283331013715 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1283331013716 substrate binding site [chemical binding]; other site 1283331013717 dimer interface [polypeptide binding]; other site 1283331013718 catalytic triad [active] 1283331013719 enolase; Provisional; Region: eno; PRK00077 1283331013720 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283331013721 dimer interface [polypeptide binding]; other site 1283331013722 metal binding site [ion binding]; metal-binding site 1283331013723 substrate binding pocket [chemical binding]; other site 1283331013724 pyruvate kinase; Provisional; Region: PRK05826 1283331013725 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283331013726 domain interfaces; other site 1283331013727 active site 1283331013728 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1283331013729 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1283331013730 putative active site [active] 1283331013731 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1283331013732 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1283331013733 substrate binding site [chemical binding]; other site 1283331013734 ATP binding site [chemical binding]; other site 1283331013735 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1283331013736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1283331013737 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283331013738 KduI/IolB family; Region: KduI; pfam04962 1283331013739 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1283331013740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331013741 putative substrate translocation pore; other site 1283331013742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331013743 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1283331013744 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1283331013745 tetrameric interface [polypeptide binding]; other site 1283331013746 NAD binding site [chemical binding]; other site 1283331013747 catalytic residues [active] 1283331013748 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1283331013749 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1283331013750 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1283331013751 PYR/PP interface [polypeptide binding]; other site 1283331013752 dimer interface [polypeptide binding]; other site 1283331013753 TPP binding site [chemical binding]; other site 1283331013754 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1283331013755 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1283331013756 TPP-binding site; other site 1283331013757 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283331013758 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283331013759 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283331013760 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283331013761 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1283331013762 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283331013763 putative ligand binding site [chemical binding]; other site 1283331013764 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1283331013765 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283331013766 putative ligand binding site [chemical binding]; other site 1283331013767 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283331013768 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283331013769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331013770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331013771 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283331013772 dimerization interface [polypeptide binding]; other site 1283331013773 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1283331013774 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1283331013775 dimer interface [polypeptide binding]; other site 1283331013776 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1283331013777 active site 1283331013778 Fe binding site [ion binding]; other site 1283331013779 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1283331013780 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283331013781 Zn binding site [ion binding]; other site 1283331013782 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1283331013783 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1283331013784 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1283331013785 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1283331013786 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1283331013787 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1283331013788 dimer interface [polypeptide binding]; other site 1283331013789 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1283331013790 N-terminal domain interface [polypeptide binding]; other site 1283331013791 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283331013792 trimer interface; other site 1283331013793 sugar binding site [chemical binding]; other site 1283331013794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283331013795 DNA binding site [nucleotide binding] 1283331013796 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1283331013797 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1283331013798 putative ligand binding site [chemical binding]; other site 1283331013799 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1283331013800 active site 1283331013801 NTP binding site [chemical binding]; other site 1283331013802 metal binding triad [ion binding]; metal-binding site 1283331013803 antibiotic binding site [chemical binding]; other site 1283331013804 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1283331013805 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283331013806 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283331013807 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283331013808 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283331013809 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283331013810 trimer interface; other site 1283331013811 sugar binding site [chemical binding]; other site 1283331013812 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283331013813 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283331013814 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283331013815 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1283331013816 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283331013817 TM-ABC transporter signature motif; other site 1283331013818 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1283331013819 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1283331013820 Walker A/P-loop; other site 1283331013821 ATP binding site [chemical binding]; other site 1283331013822 Q-loop/lid; other site 1283331013823 ABC transporter signature motif; other site 1283331013824 Walker B; other site 1283331013825 D-loop; other site 1283331013826 H-loop/switch region; other site 1283331013827 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1283331013828 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1283331013829 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1283331013830 putative ligand binding site [chemical binding]; other site 1283331013831 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1283331013832 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1283331013833 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1283331013834 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1283331013835 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1283331013836 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1283331013837 Protein of unknown function (DUF796); Region: DUF796; cl01226 1283331013838 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1283331013839 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1283331013840 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1283331013841 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1283331013842 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1283331013843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331013844 Walker A motif; other site 1283331013845 ATP binding site [chemical binding]; other site 1283331013846 Walker B motif; other site 1283331013847 arginine finger; other site 1283331013848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331013849 Walker A motif; other site 1283331013850 ATP binding site [chemical binding]; other site 1283331013851 Walker B motif; other site 1283331013852 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1283331013853 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1283331013854 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1283331013855 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1283331013856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1283331013857 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1283331013858 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1283331013859 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1283331013860 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 1283331013861 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1283331013862 electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947 1283331013863 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 1283331013864 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1283331013865 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1283331013866 SLBB domain; Region: SLBB; pfam10531 1283331013867 electron transport complex protein RnfB; Provisional; Region: PRK05113 1283331013868 Putative Fe-S cluster; Region: FeS; cl17515 1283331013869 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283331013870 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1283331013871 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1283331013872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283331013873 putative active site [active] 1283331013874 heme pocket [chemical binding]; other site 1283331013875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283331013876 ATP binding site [chemical binding]; other site 1283331013877 Mg2+ binding site [ion binding]; other site 1283331013878 G-X-G motif; other site 1283331013879 Nif-specific regulatory protein; Region: nifA; TIGR01817 1283331013880 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283331013881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331013882 Walker A motif; other site 1283331013883 ATP binding site [chemical binding]; other site 1283331013884 Walker B motif; other site 1283331013885 arginine finger; other site 1283331013886 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283331013887 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1283331013888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283331013889 FeS/SAM binding site; other site 1283331013890 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1283331013891 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1283331013892 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 1283331013893 putative catalytic residues [active] 1283331013894 NifQ; Region: NifQ; pfam04891 1283331013895 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1283331013896 active site residue [active] 1283331013897 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1283331013898 putative GSH binding site [chemical binding]; other site 1283331013899 catalytic residues [active] 1283331013900 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1283331013901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283331013902 Walker A motif; other site 1283331013903 ATP binding site [chemical binding]; other site 1283331013904 Walker B motif; other site 1283331013905 arginine finger; other site 1283331013906 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1283331013907 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1283331013908 heme-binding site [chemical binding]; other site 1283331013909 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1283331013910 FAD binding pocket [chemical binding]; other site 1283331013911 FAD binding motif [chemical binding]; other site 1283331013912 phosphate binding motif [ion binding]; other site 1283331013913 beta-alpha-beta structure motif; other site 1283331013914 NAD binding pocket [chemical binding]; other site 1283331013915 Heme binding pocket [chemical binding]; other site 1283331013916 HPP family; Region: HPP; pfam04982 1283331013917 FOG: CBS domain [General function prediction only]; Region: COG0517 1283331013918 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 1283331013919 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1283331013920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331013921 D-galactonate transporter; Region: 2A0114; TIGR00893 1283331013922 putative substrate translocation pore; other site 1283331013923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331013924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331013925 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1283331013926 dimerization interface [polypeptide binding]; other site 1283331013927 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283331013928 Right handed beta helix region; Region: Beta_helix; pfam13229 1283331013929 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283331013930 Right handed beta helix region; Region: Beta_helix; pfam13229 1283331013931 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283331013932 Right handed beta helix region; Region: Beta_helix; pfam13229 1283331013933 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283331013934 Right handed beta helix region; Region: Beta_helix; pfam13229 1283331013935 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283331013936 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283331013937 Right handed beta helix region; Region: Beta_helix; pfam13229 1283331013938 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283331013939 Right handed beta helix region; Region: Beta_helix; pfam13229 1283331013940 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283331013941 Right handed beta helix region; Region: Beta_helix; pfam13229 1283331013942 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283331013943 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283331013944 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283331013945 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283331013946 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283331013947 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283331013948 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283331013949 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283331013950 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283331013951 Right handed beta helix region; Region: Beta_helix; pfam13229 1283331013952 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1283331013953 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1283331013954 putative ligand binding site [chemical binding]; other site 1283331013955 NAD binding site [chemical binding]; other site 1283331013956 catalytic site [active] 1283331013957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331013958 D-galactonate transporter; Region: 2A0114; TIGR00893 1283331013959 putative substrate translocation pore; other site 1283331013960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331013961 D-galactonate transporter; Region: 2A0114; TIGR00893 1283331013962 putative substrate translocation pore; other site 1283331013963 galactonate dehydratase; Provisional; Region: PRK14017 1283331013964 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1283331013965 putative active site pocket [active] 1283331013966 putative metal binding site [ion binding]; other site 1283331013967 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1283331013968 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1283331013969 active site 1283331013970 intersubunit interface [polypeptide binding]; other site 1283331013971 catalytic residue [active] 1283331013972 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1283331013973 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1283331013974 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1283331013975 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283331013976 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283331013977 pyruvate kinase; Provisional; Region: PRK05826 1283331013978 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283331013979 domain interfaces; other site 1283331013980 active site 1283331013981 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283331013982 trimer interface; other site 1283331013983 sugar binding site [chemical binding]; other site 1283331013984 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283331013985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331013986 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283331013987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283331013988 Melibiase; Region: Melibiase; pfam02065 1283331013989 alpha-galactosidase; Provisional; Region: PRK15076 1283331013990 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1283331013991 NAD binding site [chemical binding]; other site 1283331013992 sugar binding site [chemical binding]; other site 1283331013993 divalent metal binding site [ion binding]; other site 1283331013994 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1283331013995 dimer interface [polypeptide binding]; other site 1283331013996 galactoside permease; Reviewed; Region: lacY; PRK09528 1283331013997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331013998 putative substrate translocation pore; other site 1283331013999 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283331014000 classical (c) SDRs; Region: SDR_c; cd05233 1283331014001 NAD(P) binding site [chemical binding]; other site 1283331014002 active site 1283331014003 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1283331014004 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1283331014005 active site 1283331014006 catalytic residues [active] 1283331014007 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1283331014008 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1283331014009 active site 1283331014010 catalytic site [active] 1283331014011 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1283331014012 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1283331014013 putative trimer interface [polypeptide binding]; other site 1283331014014 putative CoA binding site [chemical binding]; other site 1283331014015 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283331014016 trimer interface; other site 1283331014017 sugar binding site [chemical binding]; other site 1283331014018 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283331014019 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283331014020 active site 1283331014021 catalytic tetrad [active] 1283331014022 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283331014023 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1283331014024 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283331014025 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1283331014026 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283331014027 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283331014028 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1283331014029 Protein export membrane protein; Region: SecD_SecF; cl14618 1283331014030 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1283331014031 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283331014032 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1283331014033 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 1283331014034 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283331014035 dimer interface [polypeptide binding]; other site 1283331014036 active site 1283331014037 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1283331014038 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1283331014039 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283331014040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283331014041 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1283331014042 putative dimerization interface [polypeptide binding]; other site 1283331014043 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1283331014044 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283331014045 ligand binding site [chemical binding]; other site 1283331014046 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1283331014047 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283331014048 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1283331014049 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283331014050 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283331014051 metal binding site [ion binding]; metal-binding site 1283331014052 active site 1283331014053 I-site; other site 1283331014054 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283331014055 dimerization interface [polypeptide binding]; other site 1283331014056 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283331014057 dimer interface [polypeptide binding]; other site 1283331014058 putative CheW interface [polypeptide binding]; other site 1283331014059 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1283331014060 putative active site [active] 1283331014061 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1283331014062 AAA domain; Region: AAA_30; pfam13604 1283331014063 Family description; Region: UvrD_C_2; pfam13538 1283331014064 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1283331014065 Part of AAA domain; Region: AAA_19; pfam13245 1283331014066 Family description; Region: UvrD_C_2; pfam13538 1283331014067 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1283331014068 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1283331014069 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1283331014070 Arc-like DNA binding domain; Region: Arc; pfam03869 1283331014071 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1283331014072 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1283331014073 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 1283331014074 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283331014075 trimer interface; other site 1283331014076 sugar binding site [chemical binding]; other site 1283331014077 galactoside permease; Reviewed; Region: lacY; PRK09528 1283331014078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283331014079 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1283331014080 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1283331014081 substrate binding [chemical binding]; other site 1283331014082 active site 1283331014083 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1283331014084 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283331014085 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283331014086 DNA binding site [nucleotide binding] 1283331014087 domain linker motif; other site 1283331014088 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1283331014089 putative dimerization interface [polypeptide binding]; other site 1283331014090 putative ligand binding site [chemical binding]; other site 1283331014091 Staphylococcal nuclease homologues; Region: SNc; smart00318 1283331014092 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1283331014093 Catalytic site; other site 1283331014094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283331014095 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1283331014096 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1283331014097 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1283331014098 N-terminal domain interface [polypeptide binding]; other site 1283331014099 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 1283331014100 PLD-like domain; Region: PLDc_2; pfam13091 1283331014101 putative active site [active] 1283331014102 putative catalytic site [active] 1283331014103 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 1283331014104 PLD-like domain; Region: PLDc_2; pfam13091 1283331014105 putative active site [active] 1283331014106 putative catalytic site [active] 1283331014107 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1283331014108 active site 1283331014109 ATP binding site [chemical binding]; other site 1283331014110 substrate binding site [chemical binding]; other site 1283331014111 activation loop (A-loop); other site 1283331014112 AAA ATPase domain; Region: AAA_16; pfam13191 1283331014113 AAA domain; Region: AAA_11; pfam13086 1283331014114 Walker A motif; other site 1283331014115 ATP binding site [chemical binding]; other site 1283331014116 Walker B motif; other site 1283331014117 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1283331014118 AAA domain; Region: AAA_12; pfam13087 1283331014119 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1283331014120 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1283331014121 glutaminase active site [active] 1283331014122 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1283331014123 dimer interface [polypeptide binding]; other site 1283331014124 active site 1283331014125 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1283331014126 dimer interface [polypeptide binding]; other site 1283331014127 active site 1283331014128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331014129 putative DNA binding site [nucleotide binding]; other site 1283331014130 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1283331014131 putative Zn2+ binding site [ion binding]; other site 1283331014132 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1283331014133 Family description; Region: UvrD_C_2; pfam13538 1283331014134 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1283331014135 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1283331014136 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 1283331014137 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1283331014138 Substrate binding site; other site 1283331014139 Mg++ binding site; other site 1283331014140 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1283331014141 active site 1283331014142 substrate binding site [chemical binding]; other site 1283331014143 CoA binding site [chemical binding]; other site 1283331014144 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283331014145 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331014146 N-terminal plug; other site 1283331014147 ligand-binding site [chemical binding]; other site 1283331014148 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1283331014149 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1283331014150 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1283331014151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283331014152 dimer interface [polypeptide binding]; other site 1283331014153 conserved gate region; other site 1283331014154 putative PBP binding loops; other site 1283331014155 ABC-ATPase subunit interface; other site 1283331014156 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1283331014157 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1283331014158 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283331014159 Walker A/P-loop; other site 1283331014160 ATP binding site [chemical binding]; other site 1283331014161 Q-loop/lid; other site 1283331014162 ABC transporter signature motif; other site 1283331014163 Walker B; other site 1283331014164 D-loop; other site 1283331014165 H-loop/switch region; other site 1283331014166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331014167 Walker A/P-loop; other site 1283331014168 ATP binding site [chemical binding]; other site 1283331014169 Q-loop/lid; other site 1283331014170 ABC transporter signature motif; other site 1283331014171 Walker B; other site 1283331014172 D-loop; other site 1283331014173 H-loop/switch region; other site 1283331014174 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1283331014175 metal ion-dependent adhesion site (MIDAS); other site 1283331014176 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1283331014177 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1283331014178 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1283331014179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283331014180 Walker A/P-loop; other site 1283331014181 ATP binding site [chemical binding]; other site 1283331014182 Q-loop/lid; other site 1283331014183 ABC transporter signature motif; other site 1283331014184 Walker B; other site 1283331014185 D-loop; other site 1283331014186 H-loop/switch region; other site 1283331014187 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1283331014188 metal ion-dependent adhesion site (MIDAS); other site 1283331014189 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 1283331014190 Virulence factor SrfB; Region: SrfB; pfam07520 1283331014191 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283331014192 N-terminal plug; other site 1283331014193 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1283331014194 ligand-binding site [chemical binding]; other site 1283331014195 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1283331014196 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1283331014197 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1283331014198 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1283331014199 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1283331014200 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1283331014201 gamma subunit interface [polypeptide binding]; other site 1283331014202 epsilon subunit interface [polypeptide binding]; other site 1283331014203 LBP interface [polypeptide binding]; other site 1283331014204 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1283331014205 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1283331014206 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1283331014207 alpha subunit interaction interface [polypeptide binding]; other site 1283331014208 Walker A motif; other site 1283331014209 ATP binding site [chemical binding]; other site 1283331014210 Walker B motif; other site 1283331014211 inhibitor binding site; inhibition site 1283331014212 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1283331014213 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1283331014214 core domain interface [polypeptide binding]; other site 1283331014215 delta subunit interface [polypeptide binding]; other site 1283331014216 epsilon subunit interface [polypeptide binding]; other site 1283331014217 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1283331014218 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1283331014219 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1283331014220 beta subunit interaction interface [polypeptide binding]; other site 1283331014221 Walker A motif; other site 1283331014222 ATP binding site [chemical binding]; other site 1283331014223 Walker B motif; other site 1283331014224 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1283331014225 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1283331014226 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1283331014227 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1283331014228 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1283331014229 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1283331014230 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1283331014231 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1283331014232 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 1283331014233 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1283331014234 ParB-like nuclease domain; Region: ParB; smart00470 1283331014235 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1283331014236 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283331014237 P-loop; other site 1283331014238 Magnesium ion binding site [ion binding]; other site 1283331014239 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283331014240 Magnesium ion binding site [ion binding]; other site 1283331014241 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1283331014242 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1283331014243 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1283331014244 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1283331014245 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1283331014246 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1283331014247 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1283331014248 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1283331014249 active site 1283331014250 catalytic residues [active] 1283331014251 DNA binding site [nucleotide binding] 1283331014252 Int/Topo IB signature motif; other site 1283331014253 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1283331014254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1283331014255 Virulence protein [General function prediction only]; Region: COG3943 1283331014256 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1283331014257 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1283331014258 DNA methylase; Region: N6_N4_Mtase; pfam01555 1283331014259 DNA methylase; Region: N6_N4_Mtase; pfam01555 1283331014260 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1283331014261 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283331014262 ATP binding site [chemical binding]; other site 1283331014263 putative Mg++ binding site [ion binding]; other site 1283331014264 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283331014265 nucleotide binding region [chemical binding]; other site 1283331014266 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1283331014267 ATP-binding site [chemical binding]; other site 1283331014268 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1283331014269 Restriction endonuclease; Region: Mrr_cat; pfam04471 1283331014270 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283331014271 dimerization interface [polypeptide binding]; other site 1283331014272 putative DNA binding site [nucleotide binding]; other site 1283331014273 putative Zn2+ binding site [ion binding]; other site 1283331014274 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1283331014275 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1283331014276 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1283331014277 G1 box; other site 1283331014278 GTP/Mg2+ binding site [chemical binding]; other site 1283331014279 Switch I region; other site 1283331014280 G2 box; other site 1283331014281 Switch II region; other site 1283331014282 G3 box; other site 1283331014283 G4 box; other site 1283331014284 G5 box; other site 1283331014285 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1283331014286 membrane protein insertase; Provisional; Region: PRK01318 1283331014287 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1283331014288 hypothetical protein; Provisional; Region: PRK14371 1283331014289 ribonuclease P; Reviewed; Region: rnpA; PRK00396 1283331014290 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399